Type 1 Diabetes

Diabetes is a higher level of glucose in the blood than is normal. Glucose travels through your body in the blood. A hormone called insulin then helps glucose move from your blood to your cells. Once glucose is in your cells it can be used for energy. A problem making or using insulin means glucose can not move into your cells. Instead the glucose will build up in your blood. In type 1 diabetes, the body does not make insulin. This will lead to the build up of glucose in the blood, also called hyperglycemia. At the same time, your cells are not getting glucose they need to function well. Over a long period of time high blood glucose levels can also damage vital organs. The blood vessels, heart, kidneys, eyes, and nerves are most commonly affected organs. Type 1 diabetes is often found during childhood and young adulthood.

  • Causes

    Our immune system keeps us well by fighting off and destroying viruses and bacteria. Unfortunately, sometimes the immune system attacks healthy tissue. Most type 1 diabetes develop because the immune system attacks and destroys the cells that make insulin. These cells are in the pancreas.

    It is not yet clear why the immune system attacks these cells. It is believed that some people have genes that make them prone to getting diabetes. For these people, certain triggers in the environment may make the immune system attack the pancreas. The triggers are not known but may be certain viruses, foods, or chemicals.

    Type 1 diabetes may also develop as a complication of other medical conditions. It may develop in:

    • People with chronic type 2 diabetes who lose the ability to make insulin.
    • Some with chronic pancreatitis or pancreatic surgery. They may lose the cells that make insulin.
    The Pancreas
    The Pancreas
    Copyright © Nucleus Medical Media, Inc.

  • Definition

    Diabetes is a higher level of glucose in the blood than is normal. Glucose travels through your body in the blood. A hormone called insulin then helps glucose move from your blood to your cells. Once glucose is in your cells it can be used for energy. A problem making or using insulin means glucose can not move into your cells. Instead the glucose will build up in your blood.

    In type 1 diabetes, the body does not make insulin. This will lead to the build up of glucose in the blood, also called hyperglycemia. At the same time, your cells are not getting glucose they need to function well. Over a long period of time high blood glucose levels can also damage vital organs. The blood vessels, heart, kidneys, eyes, and nerves are most commonly affected organs.

    Type 1 diabetes is often found during childhood and young adulthood.

  • Diagnosis

    The doctor will ask about your symptoms. You will also be asked about your medical and family history. A physical exam will be done.

    Type 1 diabetes is diagnosed based on the results of blood tests and other criteria. These include:

    • Symptoms common with diabetes and a
      random blood test
      showing a blood sugar level greater than or equal to 200 mg/dL* (11.1 mmol/L)
    • Fasting blood test showing blood glucose levels greater than or equal to 126 mg/dL (7.0 mmol/L) on two different days—test is done after you have not eaten for eight or more hours
    • Glucose tolerance test results with blood glucose greater than or equal to 200 mg/dL (11.1 mmol/L)—test is done after you eat glucose
    • HbA1c level of 6.5% or higher—measure of blood sugar over the past 2-4 months

    *mg/dL = milligrams per deciliter of blood, mmol/L = millimole per liter of blood

    You may also need other blood tests to confirm diabetes is type 1 and not type 2. These may include:

    • Insulin level or C-peptide tests—to see how much insulin is being made by the pancreas
    • Tests that look for antibodies that are working against your pancreas

  • Prevention

    Currently, there is no known way to prevent type 1 diabetes.

    Some research is looking at the effectiveness of suppressing the immune system. This may be helpful in people who are at high risk of developing type 1 diabetes.

  • Risk Factors

    Risk factors include:

    • Family history (parent, sibling) of type 1 diabetes
    • Age: starts as early as age 4 with peak at ages 11-13
    • Sex: more common in males than females
    • Ethnicity: Northern European, Mediterranean, African Americans, Hispanics
    • Increased age of mother during pregnancy
    • Risk increases with increase in birth weight
    • Obesity
      during childhood

    • Other autoimmune illness, including:

      • Hashimoto's disease
        —disease of thyroid
      • Graves' disease
        —disease of thyroid
      • Addison's disease
        —disorder of the adrenal glands
      • Pernicious anemia
      • Celiac disease
        —autoimmune disease of the digestive tract
      • Vitiligo
        —disorder that affects the skin cells
    • Cystic fibrosis

  • Symptoms

    If you have any of these symptoms, do not assume it is due to type 1 diabetes. These symptoms may be caused by other conditions. Tell your doctor if you have any of these:

    • Weight loss
    • Increased urination
    • Extreme thirst
    • Hunger
    • Fatigue, weakness
    • Blurry vision
    • Irritability
    • Headaches


    Without insulin your body will need to find new forms of energy. This will cause an imbalance in the body called
    ketoacidosis
    .
    It is a severe state that can lead to coma or death. Symptoms of ketoacidosis include:

    • Vomiting and nausea
    • Abdominal pain
    • Dehydration
      (not enough fluid in the body)
    • Drowsiness
    • Abnormally deep and fast breathing
    • Coma
    • Dry skin and mouth
    • Fruity breath odor
    • Rapid pulse
    • Low blood pressure

  • Treatment

    Diabetes treatment goal is to maintain blood sugar at levels as close to normal as possible. Regular medical care is important for preventing or delaying complications.

    While diabetes makes blood glucose levels too high, treatment can make blood glucose levels go too low. This is called hypoglycemia. It can cause confusion, shakiness, anxiety, heart palpitations and more. If the levels fall too low it can cause seizures and loss of consciousness. You and your doctor will plan and adjust your medication and diet to keep the risk of hypoglycemia low.


    Follow your doctor's
    instructions
    for best results.