| ||Debashish Bose, MD, PhD |
Assistant Professor of Surgery
Gastrointestinal Cancer Biology Laboratory
Santosh Pawar, PhD Postdoctoral Scientist
| Debashish Bose, MD, PhD || Donna Schade |
| Gastrointestinal Cancer Biology Laboratory |
Cancer Research Institute
MD Anderson Cancer Center Orlando
6900 Lake Nona Blvd
Orlando, Florida 32827
| Phone: 407.266.7405 |
Our lab conducts translational research that focuses on GI malignancies. One primary focus of our lab is how cancers become resistant to chemotherapies. We are currently investigating colon and pancreatic cancer.
Samuel S, Gaur P, Fan F, Xia L, Gray MJ, Dallas NA, Bose D, Rodriguez-Aguayo C, Lopez-Berestein G, Plowman G, et al: Neuropilin-2 mediated beta-catenin signaling and survival in human gastro-intestinal cancer cell lines. PLoS One 2011, 6:e23208.
Fan F, Samuel S, Gaur P, Lu J, Dallas NA, Xia L, Bose D, Ramachandran V, Ellis LM: Chronic exposure of colorectal cancer cells to bevacizumab promotes compensatory pathways that mediate tumour cell migration. Br J Cancer 2011, 104:1270-1277.
Bose D, Zimmerman LJ, Pierobon M, Petricoin E, Tozzi F, Parikh A, Fan F, Dallas N, Xia L, Gaur P, et al: Chemoresistant colorectal cancer cells and cancer stem cells mediate growth and survival of bystander cells. Br J Cancer 2011, 105:1759-1767.
Bose D, Tamm E, Liu J, Marcal L, Balachandran A, Bhosale P, Fleming JB, Lee JE, Evans DB, Hwang RF: Multidisciplinary management strategy for incidental cystic lesions of the pancreas. J Am Coll Surg 2010, 211:205-215.
Bose D, Meric-Bernstam F, Hofstetter W, Reardon DA, Flaherty KT, Ellis LM: Vascular endothelial growth factor targeted therapy in the perioperative setting: implications for patient care. Lancet Oncol 2010, 11:373-382.
Bose D, Ahuja N: Genetic profiling in colorectal cancer. In Early Diagnosis of Cancer Series: Colon Cancer. Edited by Gearhart S, Ahuja N, Yang S. Philadelphia, PA: Elsevier; 2010
Gaur P, Bose D, Samuel S, Ellis LM: Targeting tumor angiogenesis. Semin Oncol 2009, 36:S12-19.
Gaur P, Bielenberg DR, Samuel S, Bose D, Zhou Y, Gray MJ, Dallas NA, Fan F, Xia L, Lu J, Ellis LM: Role of class 3 semaphorins and their receptors in tumor growth and angiogenesis. Clin Cancer Res 2009, 15:6763-6770.
Bose D, Maxhimer J, Pesce C: Cell Biology. In General Surgery Review. 2nd edition. Edited by Makary M. Washington DC: Ladner-Drysdale; 2008: 487-513
Bose D, Duncan M: Neoadjuvant chemoradiation for gastric cancer: another contender in the ring. American Journal of Hematology Oncology 2007, 6:352-362.
Bose D, Duncan M: Preoperative chemotherapy for resectable gastroesophageal cancer: the results of the MAGIC trial. American Journal of Hematology Oncology 2007, 6:151-154.
Samaniego F, Pati S, Karp JE, Prakash O, Bose D: Human herpesvirus 8 K1-associated nuclear factor-kappa B-dependent promoter activity: role in Kaposi's sarcoma inflammation? J Natl Cancer Inst Monogr 2001:15-23.