Research Studies/Clinical Trials 321.841.1620
A cancer clinical trial is a research study that is conducted by health care professionals with the intent to improve the care and treatment of cancer patients. Cancer clinical trials lead to improvements in cancer prevention, detection, and treatment for all cancer patients. In fact, most of today's treatment recommendations are based on information obtained from earlier clinical trials.
Clinical trials are an important aspect of the care provided at our center. Currently, we have clinical trials that test new ways to detect, treat, reduce side effects and improve the comfort and quality of life of people with cancer.
The decision to participate in a clinical trial is a personal decision and should never be made lightly. To make an informed decision about your treatment, it is important to consider the possible advantages and disadvantages of a clinical trial and how your participation might affect you and your family. We encourage you to discuss this and all treatment decisions with your doctor. You can leave a clinical trial at any time, and will not be penalized for doing so.
Types of Trials
- Prevention trials study how healthy people may prevent cancer. People who are at high risk of getting cancer may benefit from participation in a prevention trial.
- Early-detection/screening trials discover ways to find early-stage cancer.
- Diagnostic trials find new and better ways to determine if someone has cancer – and, if so, where cancer is located in the body; how much cancer is there; and whether or not it has spread to other parts of the body.
- Treatment trials may involve the option of being treated under investigational drugs, or under novel regimes of existing drugs, or both.
- Quality of life/supportive care trials seek to improve the comfort and quality of life of patients and their families, loved ones or caregivers.
Phases of Trials
Cancer clinical trials are conducted in phases with each phase having a different purpose and answering a different question. A new treatment or technique must show sufficient promise at each phase before continuing to the next phase.
Phase I Trials are conducted to determine treatment side effects, dosing and scheduling. All drugs in phase I trials have shown promise in tests performed in the laboratory and in animals. Researchers believe that the drug has potential to be active against cancer cells in people. Generally, patients who participate in phase I trials are no longer responding to standard therapy options.
Phase II Trials reveal how well a new treatment works against various types of cancer. More information is collected about side effects of the new treatment. Patients eligible for Phase II trials may have had previous cancer treatment, but their disease has progressed or stopped responding to standard treatment.
Phase III Trials compare the safety and effectiveness of the experimental drug or treatment with a standard treatment (therapy the patients would normally receive). A large number of patients are studied in phase III trials.
Phase IV Trials are conducted after the Food and Drug Administration (FDA) approves a treatment for use. Phase IV trials provide additional information about effectiveness and side effects.
UF Health Cancer Center at Orlando Health regularly participates in Phase II, III and IV trials.
At the Cancer Center, patients may participate in studies sponsored by several organizations, including those conducted by the National Cancer Institute, other national study groups and certain pharmaceutical companies.
We generally treat patients who are eligible for those studies locally at the Cancer Center, but occasionally we refer a patient to our Houston colleagues for more specialized care.
Besides research studies involving new chemotherapies, we also offer trials of new methods of giving chemotherapy that have been tested and approved previously. Trials may also include different methods of radiation therapy, new surgery options and ways to combat symptoms related to either treatment or to cancer.
The Cancer Center offers prevention studies to patients and families at risk of developing cancer. Prevention studies are conducted to help prevent cancer from occurring in family members or from recurring in patients who have been cured of their cancer through initial treatment.
Your doctor may offer participation in these research studies. We encourage you to ask him or her about trials for which you may qualify. These studies may possibly improve your quality of life.
For additional questions regarding clinical trials at the Cancer Center please call 321.841.1620