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EUS-guided Celiac Plexus Block vs. Sham in Chronic Pancreatitis (EPOCH)

Randomized trial of EUS-guided celiac plexus block vs. placebo for palliation of pain in chronic pancreatitis (EPOCH trial)

  • Clinical Trial Information

    Trial Contact: Garcia de Djuro, Ginette; Shepherd, Adriane R

    Trial Phone: 321.841.6649 ; 321 841-2285

  • IRB No: 23.183.09

    Protocol Abbrev: EPOCH

    Principal Investigator: C. Mel Wilcox, MD

    Age Group: Ad

    Treatment: endoscopic ultrasound-guided celiac plexus block vs. sham procedure.

    Therapies Involved: Procedural

    ClinicalTrials.gov ID: NCT06178315

  • Objective

    The primary aim of this randomized trial is to compare the rate of adequate pain relief in patients with chronic pancreatitis undergoing EUS-CPB or sham procedure. Adequate pain relief is defined as a 50% reduction in composite pain score from baseline, measured using the Brief Pain Inventory-Short Form (BPI-SF), at 1-month post-intervention.

  • Key Eligibility

    All patients aged 18 years or over with abdominal pain due to chronic pancreatitis.
    Inclusion Criteria
    1. Age ≥ 18 years
    2. Abdominal pain of at least 3 months duration and a VAS score ≥ 3, with or without
    the use of narcotic analgesics.
    3. Diagnosis of chronic pancreatitis on EUS examination, with ≥ 5 features on EUS.
    4. No other cause of abdominal pain