NSABP B-51 - A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chest wall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy
Clinical Trial Information
Trial Contact: Manchola-Orozco, Carolina; Frankos, Marie
IRB No: B-51
Protocol Abbrev: B-51
Principal Investigator: Tomas Dvorak, MD
Phase: Drug: Phase III
Age Group: Adult
Secondary Protocol No: NSABP B-51
Treatment: Radiation: regional nodal Irradiation; Radiation: chest wall Irradiation; Radiation: Whole Brain Irradiation
Therapies Involved: Radiation
ClinicalTrials.gov ID: NCT01872975
To evaluate whether the addition of chest wall+ regional nodal XRT after mastectomy or breast+ regional nodal XRT after breast-conserving surgery will significantly reduce the rates of recurrence in patients who have a complete response in the axillary nodes following neo-adjuvant therapy.
Must have pathologically or histologically proven malignant axillary lymph nodes prior to neoadjuvant therapy.