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PILOT STUDY: CAN BRUSHING FOR CYTOKINES BE USED AS A MARKER FOR INTESTINAL INFLAMMATION IN CELIAC DISEASE?

PILOT STUDY: CAN BRUSHING FOR CYTOKINES BE USED AS A MARKER FOR INTESTINAL INFLAMMATION IN CELIAC DISEASE?

  • Clinical Trial Information

    Trial Contact: Winbigler, Holly M; Roppo, Emily; Ferguson,Angel

  • IRB No: 23.054.03

    Protocol Abbrev: Celiac Cytokines

    Principal Investigator: Vijay Mehta, DO

    Age Group: Pediatric

  • Objective

    To assess that IL-15 and IL-8 is elevated, while IL-4 is decreased in biopsy homogenate, brushing samples and the serum of patients with celiac disease compared to patients that do not have celiac disease.

    Correlate the results with the degree of mucosal damage as originally classified by Marsh et al. and modified by Oberhauer. If the blood levels of the cytokines correlates with those detected in the mucosal biopsies and brushing then they would provide a more reliable assessment of mucosal healing.

  • Key Eligibility

    Children (age 1-18 years) undergoing endoscopy with the suspicion of celiac disease and controls whose caregiver will sign the consent form.