EUS-guided Celiac Plexus Block vs. Sham in Chronic Pancreatitis (EPOCH)
Randomized trial of EUS-guided celiac plexus block vs. placebo for palliation of pain in chronic pancreatitis (EPOCH trial)
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Clinical Trial Information
Trial Contact: Garcia de Djuro, Ginette; Shepherd, Adriane R
Trial Phone: 321.841.6649 ; 321 841-2285
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IRB No: 23.183.09
Protocol Abbrev: EPOCH
Principal Investigator: C. Mel Wilcox, MD
Age Group: Adult
Treatment: endoscopic ultrasound-guided celiac plexus block vs. sham procedure.
Therapies Involved: Procedural
ClinicalTrials.gov ID: NCT06178315
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Objective
The primary aim of this randomized trial is to compare the rate of adequate pain relief in patients with chronic pancreatitis undergoing EUS-CPB or sham procedure. Adequate pain relief is defined as a 50% reduction in composite pain score from baseline, measured using the Brief Pain Inventory-Short Form (BPI-SF), at 1-month post-intervention.
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Key Eligibility
All patients aged 18 years or over with abdominal pain due to chronic pancreatitis.
Inclusion Criteria
1. Age ≥ 18 years
2. Abdominal pain of at least 3 months duration and a VAS score ≥ 3, with or without
the use of narcotic analgesics.
3. Diagnosis of chronic pancreatitis on EUS examination, with ≥ 5 features on EUS.
4. No other cause of abdominal pain
