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  • Do Weight Loss Clinics Work?

    Two out of every three adults in America are either overweight or obese, but weight loss clinics may help some people get to and maintain a healthy weight long term. There are weight loss clinics and programs all over the country, and while many are credible, it’s important to do your research if you’re considering this option.

  • What You Should Know Before Joining a Cancer Clinical Trial

    Choosing to join a cancer clinical trial is not an easy decision – and not one that should be made lightly.

  • Choosing Between an Orthopedic Walk-In Clinic and the ER

    With every orthopedic emergency – from sprained ankles to broken fingers to arthritis flareups – there arises an urgent question: Where should you go for immediate help?

  • Why Go to a Comprehensive Care Clinic for MS Treatment?

    Multiple sclerosis (MS) is a complicated disease. The neurological disease encompasses the central nervous system and affects the brain, spinal cord and optic nerves. With this disease, the immune system mistakenly attacks the central nervous system, causing inflammation and scar tissue that damages nerve fibers and myelin, a fatty substance that surrounds and protects the nerve fibers.  That damage can change or stop messages within the central nervous system.

  • Cancer Genetics High Risk Clinic

    Much of the focus on cancer has been what to do after you’re diagnosed, but some patients may be especially high risk due to their genetics. Accounting for this population, the UF Health Cancer Center at Orlando Health opened a new comprehensive cancer center in September. The center provides genetic testing to help people with a family history of cancer understand their risk and potentially take preventative action that may save their lives.

    The Story of Two Sisters

  • Stress vs. Clinical Anxiety and How to Spot the Difference

    Many factors may be contributing to the rise in anxiety disorders among children and adolescents — the information influx of digital media for one, but also earlier diagnosis. Recognizing the problem is the first step in helping your child if they are indeed suffering from anxiety. Because parents and adult caregivers are often the first to spot signs, knowing what to look out for is crucial. 

  • Personal Prescriptions: Clinical trial explores new targets for treating advanced breast cancer

    Breast cancer is the most common cancer affecting women in the United States and worldwide. When diagnosed early, it has more than a 90% cure rate. Yet, even when breast cancer spreads outside the breast and becomes metastatic, women may survive many years on effective therapy. When deciding how to treat breast cancer, the breast profile, or “phenotype,” guides oncologists to select the treatment options most likely to control the cancer and maybe even get rid of it altogether.

    So how do we do that?

    Currently, we determine the phenotype by measurement of the presence or absence of Estrogen Receptor, Progesterone Receptor, and the Her2neu growth factor receptor on cancer cells.  Scientists are also studying other biologic features of cancer cells to look for new “targets” to improve therapy. For patients suffering from metastatic breast cancer that is Estrogen Receptor or Progesterone Receptor positive, our standard of care is to initiate estrogen-blocking or estrogen-lowering treatment called “endocrine therapy.” If the cancer is life threatening, or vital organ function is being compromised, then chemotherapy is often initiated first to get control of the cancer, followed by endocrine therapy.  Examples of endocrine therapy include tamoxifen, aromatase inhibitors, ovarian suppression, fulvestrant and a new drug on the market, everolimus.  In 2012, the FDA approved everolimus (a drug that blocks a critical pathway in cancer cells) after research and clinical trials showed a significant improvement in the response to the combination of exemestane plus everolimus, versus using exemestane alone. This drug is now used for women with advanced estrogen receptor positive breast cancer.

    A new clinical trial at UF Health Cancer Center at Orlando Health

    We have just started a new clinical trial (research study) at UF Health Cancer Center at Orlando Health that explores another target, the PI3K pathway. PI3K stands for phosphatidylinositol-3-kinase. This is an important enzyme in normal cells that regulates multiple functions of cells. It appears to play a critical role in the crossroads of the intricate molecular messaging that occurs in cancer cells. In this clinical trial, we are testing BKM120, an oral medication that targets the PI3K pathway. This trial will look at whether or not this oral medication, combined with fulvestrant (another cancer fighting medication), may help to combat a patient's cancer.

    Women are eligible for the trial if they:

    Are 18 years or older with a biopsy proven diagnosis of breast cancer and tumor tissue available for special studies. Have inoperable locally advanced or metastatic breast cancer Have Estrogen Receptor or Progesterone Receptor positive phenotype and are Her2neu receptor negative Are postmenopausal Have been treated with aromatase inhibitors (anastrazole, letrozole, or exemustane) and their disease has progressed or recurred Have adequate liver function, good control of blood sugar, and adequate heart function without irregular heart rhythm Have not received more than one type of chemotherapy for metastatic disease and do not have symptoms from central nervous system metastases Do not have significant psychiatric disorder, major depression, major anxiety, or thoughts of suicidePatients who choose to enter clinical trials are given complete information regarding the details of the trial, the safety issues, and the opportunity to withdraw from the trial at any time without consequences. The process of educating patients so that they can decide whether to participate is called the “informed consent process.” Federal guidelines spell out the process for entering patients on clinical trials, the FDA approves and receives reports about the trial, a Safety Committee monitors trial safety, and Institutional Review Boards oversee the protection of the rights and welfare of research patients.

    My Personal Prescription:

    If you or a loved one has been diagnosed with cancer, ask your consultant about available clinical trials and your eligibility.

  • Hometown Spirit — Jennifer Quilty, DNP, APRN, Chief Clinical Officer, Orlando Health Medical Group

    An Orlando native, Jennifer Quilty grew up knowing about the excellent reputation of the Orlando Health hospital system — specifically, the Orlando Health Arnold Palmer Hospital for Children. Jennifer wanted to pursue nursing at a children’s hospital, and she started working at Orlando Health Arnold Palmer shortly after graduating from college.

  • Sticking to Your Diet In The New Year

    Did you know that just 8 percent of people stick to their New Year’s resolutions? That number is startling because it means that 92 percent of us fail every year to keep a promise we’ve made to ourselves.

  • Warmer Months are Good for Heart Health

    Living in Florida, we have a lot to be thankful for — especially because it’s warm year round. Now, it appears that this warm weather is good for more than just enjoying days at the beach.