Journals and Research
Research and education are foundational to the mission of Orlando Health and our Digestive Health Institute. As frequent contributors to leading publications on gastroenterology and endoscopy, our physicians share their research and clinical insights with a national and international community of colleagues.
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| Author(s) | Title | Description | Publish Date |
|---|---|---|---|
| Differential encoding of mammalian proprioception by voltage-gated sodium channels | Animals that require purposeful movement for survival are endowed with mechanosensory neurons called proprioceptors that provide essential sensory feedback from muscles and joints to spinal cord circuits, which modulates motor output. Despite the essential nature of proprioceptive signaling in daily... | 9/10/2024 | |
| Patient-Related Factors Associated With Long-Term Outcomes After Successful Endoscopic Balloon Dilation For Crohns Disease-Associated Ileo-Colic Strictures A Systematic Review and Meta-analysis | CONCLUSIONS: The use of biologics and endoscopic disease remission at the time of EBD were protective factors against the need for surgery. No previous surgery or use of steroids at the time of EBD was associated with the need for surgery during follow-up. | 8/23/2024 | |
| TEMPORARY REMOVAL American Society for Gastrointestinal Endoscopy guideline on the role of therapeutic EUS in the management of biliary tract disorders summary and recommendations | The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at https://www.else... | 7/30/2024 | |
| Big Brother Is Watching Artificial Intelligence in Endoscopy - Hype or Reality | Artificial intelligence (AI) has become a part of many image-based specialties, such as radiology and pathology, as well as medical specialties in which "oscopy" is the key to current practice. In gastroenterology, for example, AI is being explored as an aid to endoscopists to visually distinguish p... | 2/6/2024 | |
| Beta-blockers and cirrhosis Striking the right balance | Decompensated cirrhosis is associated with a significantly increased risk of mortality. Variceal hemorrhage (VH) further increases the risk of mortality, and of future variceal bleed events. Non-selective beta-blockers (NSBBs) are effective therapy for primary and secondary prophylaxis of VH and hav... | 1/23/2024 | |
| Diagnostic accuracy of bowel ultrasonography in patients with inflammatory bowel disease a systematic review and meta-analysis | CONCLUSION: The high diagnostic accuracy of BUS in detecting bowel wall inflammation suggests utilizing regular BUS as the primary modality, with subsequent consideration of SICUS if clinically warranted. | 1/15/2024 | |
| Impact of Slim Linear Echoendoscope on the Practice of EUS | CONCLUSIONS: A very experienced EUS team required SLE in 1.1% of consecutive examinations. Our findings suggest that when used, 95% of patients benefitted as it had a significant impact on their clinical management. | 11/20/2023 | |
| Orlando Protocol for single session ductal clearance of common bile duct stones at endosopic retrograde cholangiopancreatography | CONCLUSIONS: A predetermined protocol optimized outcomes by enabling single-session ductal clearance of CBDS with high technical success and low adverse events. | 11/13/2023 | |
| A physics-based machine learning technique rapidly reconstructs the wall-shear stress and pressure fields in coronary arteries | With the global rise of cardiovascular disease including atherosclerosis, there is a high demand for accurate diagnostic tools that can be used during a short consultation. In view of pathology, abnormal blood flow patterns have been demonstrated to be strong predictors of atherosclerotic lesion inc... | 10/16/2023 | |
| Treatment of walled-off necrosis using lumen-apposing metal stents versus plastic stents a systematic review and meta-analysis of data from randomized trials | CONCLUSIONS: Except for procedure duration, there is no significant difference in clinical outcomes for patients with WON treated using LAMSs or plastic stents. | 9/6/2023 | |
| Serum hepcidin levels in chronic liver disease a systematic review and meta-analysis | CONCLUSIONS: Serum hepcidin levels are altered in common forms of CLD albeit not in a consistent direction. Additional study is needed to determine how changes in hepcidin levels are related to dysregulation of iron metabolism in CLD. | 8/4/2023 | |
| Gastrointestinal bleeding and pro-angiogenic shift in the angiopoietin axis with continuous flow left ventricular assist device implantation | CONCLUSION: CF-LVAD recipients demonstrated a shift toward a pro-angiogenic phenotype in the angiopoietin axis that is significantly associated with GIB and may be linked to low pulse pressure. | 7/28/2023 | |
| Recent advances in endoscopic management of gastric neoplasms | The development and clinical application of new diagnostic endoscopic technologies such as endoscopic ultrasonography with biopsy, magnification endoscopy, and narrow-band imaging, more recently supplemented by artificial intelligence, have enabled wider recognition and detection of various gastric ... | 6/5/2023 | |
| Pancreatic Cancer Screening for At-Risk Individuals Pancreas Scan Study Yield, Harms, and Outcomes From a Prospective Multicenter Study | INTRODUCTION: Guidelines endorse pancreatic cancer screening in genetically susceptible individuals. We conducted a prospective, multicenter study to determine yield, harms, and outcomes of pancreatic cancer screening. | 5/4/2023 | |
| Optimal alpha-1 antitrypsin level cutoffs for genotype identification in patients with chronic liver disease | BACKGROUND: Controversy exists whether alpha-1 antitrypsin (A1AT) genotype testing should be performed as a first-line screening for A1AT heterozygous variants. | 5/3/2023 | |
| Diagnostic accuracy of convolutional neural network-based machine learning algorithms in endoscopic severity prediction of ulcerative colitis a systematic review and meta-analysis | CONCLUSIONS: CNN-based machine learning algorithms demonstrated excellent pooled diagnostic accuracy parameters in the endoscopic severity assessment of UC. Using UCEIS scores in CNN training might offer better results than the MES. Further studies are warranted to establish these findings in real c... | 4/24/2023 | |
| Impact of endoprosthesis type on inflammatory response in patients undergoing endoscopic drainage of pancreatic fluid collections | CONCLUSIONS: Use of plastic stents as compared to LAMS was associated with a higher proportion of SIRS and new organ failure that prolonged hospital stay. Therefore, placement of LAMS is recommended in sick patients and those with ≥33% necrosis to minimize inflammatory response. | 4/11/2023 | |
| The NAFLD Decompensation Risk Score External Validation and Comparison to Existing Models to Predict Hepatic Events in a Retrospective Cohort Study | CONCLUSIONS: In an urban, racially and ethnically diverse population, the Iowa Model performed well to identify NAFLD patients at higher risk for liver-related complications. The model provides the individual probability of developing hepatic events and identifies patients in need of early intervent... | 3/23/2023 | |
| Artificial intelligence in medical imaging for cholangiocarcinoma diagnosis A systematic review with scientometric analysis | CONCLUSION: Our results suggest that there is increasing evidence to support the role of AI in the diagnosis of CCA. CNN-based computer vision of cholangioscopy images appears to be the most promising modality for extrahepatic CCA diagnosis. Our social network analysis highlighted an Asian and Ameri... | 3/15/2023 | |
| Artificial intelligence in endoscopic imaging for detection of malignant biliary strictures and cholangiocarcinoma a systematic review | CONCLUSIONS: Our results suggest that there is increasing evidence to support a role for AI in the diagnosis of malignant biliary strictures and CCA. CNN-based machine leaning of cholangioscopy images appears to be the most promising, while CNN-EUS has the best clinical performance application. | 3/3/2023 | |
| Ileocolonic intussusception presenting as chronic diarrhea in an elderly woman | Video 1Colonoscopy findings of cecal mass as a lead point causing intussusception. | 2/23/2023 | |
| Portal vein thrombosis, hepatic decompensation, and survival in patients with porto-sinusoidal vascular disease and portal hypertension | CONCLUSIONS: PSVD with PH is not a benign entity. Mortality, PVT and hepatic decompensation are common. Patients with PSVD must be closely monitored, including those who only have non-specific clinical signs (e.g., splenomegaly) of PH. | 1/24/2023 | |
| Alpha-1-Antitrypsin PiMZ variant increases risk of developing hepatic events in nonalcoholic fatty liver disease patientssupsup | CONCLUSION: Patients with NAFLD and A1AT Pi*MZ variant are at increased risk for developing hepatic decompensation. NAFLD patients should be offered A1AT genotyping for risk stratification, counseling, and multidisciplinary intervention for NAFLD. | 12/12/2022 | |
| Endoscopic Stricturotomy and Strictureplasty | Strictures in inflammatory bowel disease (IBD) usually occur because of long-standing inflammation and fibrosis causing luminal narrowing. Strictures in the setting of Crohn's disease (CD) can occur de novo, or in the postsurgical setting (anastomotic strictures). Historically these strictures are m... | 10/6/2022 | |
| Challenges of developing and executing a multi-site registry for a novel device with evolving indications for use | CONCLUSIONS: The Prospective Registry for Trans-Orifice Endoscopic Suturing Applications (ES Registry) was an effective Phase 4, postmarketing registry aimed at capturing pragmatic, real-world use of a novel device. These findings serve to solidify the role of endoscopic suturing in clinical practic... | 8/3/2022 | |
| Early prediction of post-ERCP pancreatitis by post-procedure amylase and lipase levels A systematic review and meta-analysis | Background and study aims Post-ERCP pancreatitis (PEP) is the most common complication attributed to the procedure, its incidence being approximately 9.7 %. Numerous studies have evaluated the predictive efficacy of post-procedure serum amylase and lipase levels but with varied procedure-to-test ti... | 7/18/2022 | |
| A Case of Duodenal Spot Diagnosis | Pseudomelanosis duodeni is a rare finding usually described as a black/brown speckled or tattooed appearance of the intestinal mucosa. Although an incidental finding, it has been associated with different medications and chronic medical conditions such as diabetes mellitus and chronic renal failure.... | 7/8/2022 | |
| Management of pouch neoplasia consensus guidelines from the International Ileal Pouch Consortium | Surveillance pouchoscopy is recommended for patients with restorative proctocolectomy with ileal pouch-anal anastomosis in ulcerative colitis or familial adenomatous polyposis, with the surveillance interval depending on the risk of neoplasia. Neoplasia in patients with ileal pouches mainly have a g... | 7/7/2022 | |
| Comparison Between Intravenous and Intramuscular Octreotide in the Management of Heydes Syndrome | Heyde's syndrome is defined as a triad of aortic stenosis, anemia due to angiodysplasia-related bleeding, and von Willebrand syndrome type 2A. It is a rare disease and a diagnostic challenge. Treatment modalities include symptomatic management, blood transfusions, aortic valve replacement, and medic... | 7/5/2022 | |
| Gastrointestinal endoscope contamination rates - elevators are not only to blame a systematic review and meta-analysis | Background and study aims Duodenoscopes that are contaminated due to inadequate reprocessing are well-documented. However, studies have demonstrated poor reprocessing of other kinds of endoscopes as well, including echoendoscopes, gastroscopes, and colonoscopes. We estimated the contamination rate b... | 6/13/2022 | |
| Basic and Advanced Biliary Cannulation How Do I Do It | Successful biliary cannulation of a native papilla is usually the rate-limiting step toward a successful ERCP. Standard cannulation techniques usually succeed, particularly when utilizing the wire-guided technique. There are, however, a myriad of confirmations of the major papilla as well as anatomi... | 6/12/2022 | |
| Application of artificial intelligence in diagnosis of pancreatic malignancies by endoscopic ultrasound a systemic review | CONCLUSION: AI reported a high sensitivity with high specificity and accuracy to diagnose PC, differentiate PC from CP, and differentiate benign from malignant IPMN when used with EUS. | 5/5/2022 | |
| Endoscopic ultrasound-guided gastroenterostomy versus surgical gastrojejunostomy in treatment of malignant gastric outlet obstruction Systematic review and meta-analysis | Background and study aims Palliative treatment of malignant gastric outlet obstruction (GOO) has conventionally been with surgical gastrojejunostomy (SGJ). Advent of devices like lumen apposing metal stents has made endoscopic ultrasound-guided gastroenterostomy (EUS-GE) a potential alternative to ... | 4/18/2022 | |
| Gastric Xanthomatosis Secondary to Lipoprotein X in Primary Biliary Cholangitis | Primary biliary cholangitis (PBC) is a rare autoimmune disease characterized by intralobular bile duct destruction. Patients typically present with generalized symptoms including fatigue and pruritis, and less commonly, manifestations of lipid deposition including xanthomas and xanthelasmas. We repo... | 4/11/2022 | |
| The h-ANN Model Comprehensive Colonoscopy Concept Compilation Using Combined Contextual Embeddings | Colonoscopy is a screening and diagnostic procedure for detection of colorectal carcinomas with specific quality metrics that monitor and improve adenoma detection rates. These quality metrics are stored in disparate documents i.e., colonoscopy, pathology, and radiology reports. The lack of integrat... | 4/4/2022 | |
| TAX-Corpus Taxonomy based Annotations for Colonoscopy Evaluation | Colonoscopy plays a critical role in screening of colorectal carcinomas (CC). Unfortunately, the data related to this procedure are stored in disparate documents, colonoscopy, pathology, and radiology reports respectively. The lack of integrated standardized documentation is impeding accurate report... | 3/18/2022 | |
| Factors Contributing to Snorkel Drowning in Hawaii | Causes of the extraordinarily high and increasing incidence of snorkeler drownings in Hawai'i have remained unexplained for years. Defining the mechanisms and factors predisposing to drowning while snorkeling is needed to provide recommendations to substantially mitigate the incidence of this form o... | 3/9/2022 | |
| Sarcopenia in hepatocellular carcinoma Current knowledge and future directions | Liver cancer is the second most occurring cancer worldwide and is one of the leading causes of cancer-related deaths. Hepatocellular carcinoma (HCC) is the most common (80%-90%) type among malignant liver cancers. Sarcopenia occurs very early in HCC and can predict and provide an opportunity to impr... | 2/7/2022 | |
| The Evolution of Device-Assisted Enteroscopy From Sonde Enteroscopy to Motorized Spiral Enteroscopy | The introduction of capsule endoscopy in 2001 opened the last "black box" of the gastrointestinal tract enabling complete visualization of the small bowel. Since then, numerous new developments in the field of deep enteroscopy have emerged expanding the diagnostic and therapeutic armamentarium again... | 1/10/2022 | |
| Contamination Rates in Duodenoscopes Reprocessed Using Enhanced Surveillance and Reprocessing Techniques A Systematic Review and Meta-Analysis | CONCLUSION: While ESRT may improve the disinfection process, a post-ESRT contamination rate of 5% is not negligible. Ongoing efforts to mitigate the rate of contamination by improving disinfection techniques and innovations in duodenoscope design to improve safety are warranted. | 1/3/2022 | |
| Endoscopic ultrasound-guided vascular interventions Current insights and emerging techniques | Endoscopic ultrasound (EUS) is one of the significant breakthroughs in the field of advanced endoscopy. In the last two decades, EUS has evolved from a diagnostic tool to a real-time therapeutic modality. The luminal gastrointestinal (GI) tract provides a unique opportunity to access multiple vascul... | 11/18/2021 | |
| The pancreas and COVID-19 a clinical conundrum | With the progression of the COVID-19 pandemic, the classic manifestations of COVID-19 (e.g., persistent fever, dry cough, pneumonia, and acute respiratory distress syndrome in the severe disease) have expanded to include less common complications of the extrapulmonary organs. Recent evidence has sho... | 11/17/2021 | |
| Treatment of pouchitis, Crohns disease, cuffitis, and other inflammatory disorders of the pouch consensus guidelines from the International Ileal Pouch Consortium | Pouchitis, Crohn's disease of the pouch, cuffitis, polyps, and extraintestinal manifestations of inflammatory bowel disease are common inflammatory disorders of the ileal pouch. Acute pouchitis is treated with oral antibiotics and chronic pouchitis often requires anti-inflammatory therapy, including... | 11/14/2021 | |
| Scope of Artificial Intelligence in Gastrointestinal Oncology | Gastrointestinal cancers are among the leading causes of death worldwide, with over 2.8 million deaths annually. Over the last few decades, advancements in artificial intelligence technologies have led to their application in medicine. The use of artificial intelligence in endoscopic procedures is a... | 11/13/2021 | |
| Endoscopic biliary drainage for malignant distal biliary obstruction Which is better - endoscopic retrograde cholangiopancreatography or endoscopic ultrasound | Presently, following endoscopic ultrasound (EUS)-guided biopsy, an endoscopic retrograde cholangiopancreatography (ERCP) with transpapillary stenting is performed for palliation of malignant distal biliary obstruction (MDBO). However, technical failure and postprocedure pancreatitis are limitations ... | 11/8/2021 | |
| Safety and efficacy of a novel resection system for direct endoscopic necrosectomy of walled-off pancreas necrosis a prospective, international, multicenter trial | CONCLUSIONS: The new PED system seems to be a safe and effective treatment tool for WOPN, resulting in fewer interventions and lower hospital duration when compared with published data on using conventional instruments. Randomized controlled trials comparing the PED system with conventional DEN are ... | 9/25/2021 | |
| Factitious Gastrointestinal Bleeding A Case Series and Review | Factitious gastrointestinal bleeding (GIB) is a manifestation of factitious disorder (FD) wherein patients feign GIB in the absence of external gain. As it can be a challenging diagnosis to make, factitious GIB often leads to multiple tests, exposure to contrast agents and radiation, invasive endosc... | 9/23/2021 | |
| Education and gastroenterology fellow knowledge about endoscopic mucosal resection of colon adenomas a survey-based study | Background and study aims Endoscopic mucosal resection (EMR) is an effective way to remove large (> 2 cm) colon adenomas. Training about it has not been standardized in fellowship programs. This study was aimed at evaluating the education and knowledge of gastroenterology fellows about EMR of color... | 8/27/2021 | |
| Diagnosis and classification of ileal pouch disorders consensus guidelines from the International Ileal Pouch Consortium | Restorative proctocolectomy with ileal pouch-anal anastomosis is an option for most patients with ulcerative colitis or familial adenomatous polyposis who require colectomy. Although the construction of an ileal pouch substantially improves patients' health-related quality of life, the surgery is, d... | 8/20/2021 | |
| Validation of the Orlando Protocol for endoscopic management of pancreatic fluid collections in the era of lumen-apposing metal stents | CONCLUSIONS: A structured approach integrating LAMS with selective use of plastic stents improved treatment success in patients with PFCs compared to an approach using only plastic stents. | 7/31/2021 | |
| Pain Experience in Pancreatitis Strong Association of Genetic Risk Loci for Anxiety and PTSD in Patients With Severe, Constant, and Constant-Severe Pain | INTRODUCTION: Recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) are progressive inflammatory syndromes with variable features. Pain is the primary feature that contributes to low physical and mental quality of life with a third of patients reporting severe pain. Pain experience is wor... | 7/8/2021 | |
| Impact of Race and Socioeconomics Disparities on Survival in Young-Onset Colorectal Adenocarcinoma-A SEER Registry Analysis | CONCLUSIONS: Survival disparities were found among all races with young-onset colorectal adenocarcinoma. The pattern of SEDH influencing survival was unique to each race. Overall higher income levels, high school education, private insurance, and marital status appeared to be independent factors con... | 7/2/2021 | |
| Consolidated EHR Workflow for Endoscopy Quality Reporting | Although colonoscopy is the most frequently performed endoscopic procedure, the lack of standardized reporting is impeding clinical and translational research. Inadequacies in data extraction from the raw, unstructured text in electronic health records (EHR) pose an additional challenge to procedure... | 5/27/2021 | |
| Intraluminal Endovascular Coil Migration A Rare Complication Post-Embolization of the Gastroduodenal Artery for a Previously Bleeding Duodenal Ulcer | Transarterial angiographic embolization is a highly effective, safe treatment for non-variceal upper gastrointestinal bleeding refractory to endoscopic intervention. However, intraluminal coil migration is a possible complication. Coil migration, while usually a self-limiting process, can lead to si... | 5/27/2021 | |
| Hepatic Manifestations of Nonhepatotropic Infectious Agents Including Severe Acute Respiratory Syndrome Coronavirus-2, Adenovirus, Herpes Simplex Virus, and Coxiella burnetii | Nonhepatotropic viruses such as adenovirus, herpes simplex virus, flaviviruses, filoviruses, and human herpes virus, and bacteria such as Coxiella burnetii, can cause liver injury mimicking acute hepatitis. Most of these organisms cause a self-limited infection. However, in immunocompromised patient... | 5/24/2021 | |
| Single-use duodenoscopes where are we and where are we going | PURPOSE OF REVIEW: Given the growing concerns about infection transmission from use of contaminated reusable duodenoscopes, technological advancements have been made that vary from modifications of existing designs to development of single-use devices. | 5/19/2021 | |
| Expert consensus on endoscopic papillectomy using a Delphi process | CONCLUSIONS: This is the first step in developing an international consensus-based algorithm for endoscopic management of papillary adenomas. Surprisingly, in many areas consensus could not be achieved. These aspects should be the focus of future studies. | 4/22/2021 | |
| Endoscopic evaluation of surgically altered bowel in inflammatory bowel disease a consensus guideline from the Global Interventional Inflammatory Bowel Disease Group | The majority of patients with Crohn's disease and a proportion of patients with ulcerative colitis will ultimately require surgical treatment despite advances in diagnosis, therapy, and endoscopic interventions. The surgical procedures that are most commonly done include bowel resection with anastom... | 4/19/2021 | |
| The burn of ranitidine recall current insights and mitigation strategies | Ranitidine was one of the most commonly used medications for the treatment of gastroesophageal reflux disease. On 1 April 2020, the US Food and Drug Administration requested all manufacturers to immediately withdraw ranitidine from the market because of concern of higher than acceptable levels of N-... | 4/19/2021 | |
| Endoscopic Mucosal Resection for Colonic Mucosal Neoplasia and Evaluation of Long-Term Recurrence A Single-Center Experience of 500 Cases | CONCLUSIONS: EMR is an effective, minimally invasive technique for the treatment of large laterally spreading lesions. Although recurrence is a concern, its risk is low (21.8% on SC1 and 9.8% on SC2) and was managed endoscopically in 96.3% cases on follow-up endoscopy. | 3/31/2021 | |
| Comparison of Biliary Drainage Techniques for Malignant Biliary Obstruction A Systematic Review and Network Meta-analysis | CONCLUSIONS: The available evidence did not favor any intervention for drainage of malignant biliary obstruction across all the outcomes assessed. ERCP with or without EUS should be considered first to allow simultaneous tissue acquisition and biliary drainage. | 3/29/2021 | |
| Application of artificial intelligence in pancreaticobiliary diseases | The role of artificial intelligence and its applications has been increasing at a rapid pace in the field of gastroenterology. The application of artificial intelligence in gastroenterology ranges from colon cancer screening and characterization of dysplastic and neoplastic polyps to the endoscopic ... | 3/1/2021 | |
| Endobariatric procedures for obesity clinical indications and available options | Obesity remains a growing public health epidemic that has increased healthcare costs and related comorbidities. Current treatment guidelines encourage a multidisciplinary approach starting from patient selection, interventions, and long-term follow-up to maintain weight loss. However, these conserva... | 2/25/2021 | |
| Liver Biopsy in Pregnancy Two Case Reports and Review of the Literature | The etiology of most cases of liver diseases in pregnancy can be diagnosed with a thorough history, physical examination, laboratory values, serology, and noninvasive imaging. However, atypical clinical and laboratory presentations of liver diseases/chemistries require a liver biopsy to render an ac... | 1/12/2021 | |
| Luminal-apposing stents for benign intraluminal strictures a large United States multicenter study of clinical outcomes | CONCLUSIONS: Using LAMS for treatment of short benign GI strictures is safe and effective. Larger LAMS, such as the new 20 mm in diameter, may have a lower stent migration rate compared to smaller diameter LAMS. | 1/8/2021 | |
| Aspirin for prevention of colorectal cancer in the elderly friend or foe | Cancer is the leading cause of death among men and women aged 60-79 years. Colorectal cancer is the third most common cancer in males and the second most common in females, with about 0.8 million deaths worldwide per year. Individuals older than 50 years account for 20-50% of colonic adenomas. Sever... | 1/8/2021 | |
| Endoscopic full-thickness resection of polyps involving the appendiceal orifice a multicenter international experience | CONCLUSIONS: The FTRD is a promising non-surgical alternative for resecting appendiceal lesions, but appendicitis occurs in 1/6 cases. | 1/4/2021 | |
| Endoscopic mucosal resection for early esophageal carcinoma is effective and safe but necessitates continued surveillance | CONCLUSION: EMR is effective and safe for the management of early EC. The risk of cancer recurrence, albeit small, warrants surveillance. Complete eradication of Barrett's should be attempted in all patients after EMR of AC. | 11/17/2020 | |
| Ursodeoxycholic Acid Decreases Incidence of Primary Biliary Cholangitis and Biliary Complications After Liver Transplantation A Meta-Analysis | After liver transplantation (LT), the role of ursodeoxycholic acid (UDCA) is not well characterized. We examine the effect of UDCA after LT in the prophylaxis of biliary complications (BCs) in all-comers for LT and the prevention of recurrent primary biliary cholangitis (rPBC) in patients transplant... | 11/13/2020 | |
| Does timing of endoscopy affect outcomes in patients with upper gastrointestinal bleeding a systematic review and meta-analysis | CONCLUSION: Given the outcomes and limitations, our meta-analysis did not demonstrate clear benefit of performing EGD within 24 h of presentation for UGIB (particularly NVB). | 11/12/2020 | |
| Inflammatory bowel disease amid the COVID-19 pandemic impact, management strategies, and lessons learned | The current outbreak of COVID-19 pandemic caused by SARS-CoV-2 has affected nearly 188 countries. Patients with severe COVID-19 are more commonly elderly and suffer from comorbidities such as hypertension, diabetes mellitus, coronary artery disease, chronic pulmonary disease, obesity, and cancer. In... | 11/9/2020 | |
| Cannabis hyperemesis syndrome an update on the pathophysiology and management | Cannabis hyperemesis syndrome (CHS) is a form of functional gut-brain axis disorder characterized by bouts of episodic nausea and vomiting worsened by cannabis intake. It is considered as a variant of cyclical vomiting syndrome seen in cannabis users especially characterized by compulsive hot bathin... | 11/9/2020 | |
| Enhanced EUS imaging with videos | CONCLUSIONS: Elastography and CE-EUS may improve the real-time evaluation of intra- and extraluminal lesions as an adjunct to standard B-mode and Doppler imaging. They are not a replacement for EUS-guided tissue sampling but provide adjunctive diagnostic information in specific clinical situations. ... | 11/1/2020 | |
| Scope of Artificial Intelligence in Screening and Diagnosis of Colorectal Cancer | Globally, colorectal cancer is the third most diagnosed malignancy. It causes significant mortality and morbidity, which can be reduced by early diagnosis with an effective screening test. Integrating artificial intelligence (AI) and computer-aided detection (CAD) with screening methods has shown pr... | 10/20/2020 | |
| Prospective evaluation of an assessment tool for technical performance of duodenoscopes | CONCLUSIONS: The newly developed assessment tool appears reliable and valid for evaluating the technical performance of duodenoscopes. Registration: ClinicalTrials.gov Identifier: NCT04004533. | 10/2/2020 | |
| Primary Colonic Lymphoma With Paraneoplastic Hypercalcemia | Primary colonic lymphoma is a rare tumor accounting for 0.1%-0.5% of all colorectal malignancies. We describe a 63-year-old man whose initial presentation was altered mental status due to hypercalcemia. Physical examination revealed a hard, right-sided abdominal mass. Abdominal computed tomography s... | 9/28/2020 | |
| Current and future implications of COVID-19 on gastroenterology training and clinical practice | The novel coronavirus disease 2019 (COVID-19) pandemic has affected almost every country on the globe, affecting 185 countries with more than 2.6 million cases and 182,000 deaths as of April 22, 2020. The United States (US) has seen an exponential surge in the COVID-19 patients and has become the ep... | 9/21/2020 | |
| Mucosa-Associated Microbiota in Barretts Esophagus, Dysplasia, and Esophageal Adenocarcinoma Differ Similarly Compared With Healthy Controls | INTRODUCTION: Alterations in the composition of the human gut microbiome and its metabolites have been linked to gut epithelial neoplasia. We hypothesized that differences in mucosa-adherent Barrett's microbiota could link to risk factors, providing risk of progression to neoplasia. | 9/21/2020 | |
| Equivalent performance of single-use and reusable duodenoscopes in a randomised trial | CONCLUSION: Given the overall safety profile and similar technical performance, single-use duodenoscopes represent an alternative to reusable duodenoscopes for performing low-complexity ERCP procedures in experienced hands. | 9/8/2020 | |
| Volatile organic compounds in bile can distinguish pancreatic cancer from chronic pancreatitis a prospective observational study | CONCLUSION: The measurement of VOCs in bile helped to accurately distinguish pancreatic cancer from chronic pancreatitis. | 9/7/2020 | |
| Multimedia based education on bowel preparation improves adenoma detection rate Systematic review amp; meta-analysis of randomized controlled trials | CONCLUSION: Pre-colonoscopy patient education using multimedia based platforms seems to improve ADR and the adequacy of bowel preparation. | 8/15/2020 | |
| International consensus guidelines on interventional endoscopy in chronic pancreatitis Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club | CONCLUSIONS: This international expert consensus guideline provides evidenced-based statements concerning indications and key aspects for interventional endoscopy in the management of patients with chronic pancreatitis. | 8/15/2020 | |
| Importance of Disconnected Pancreatic Duct Syndrome in Recurrence of Pancreatic Fluid Collections Initially Drained Using Lumen-Apposing Metal Stents | CONCLUSIONS: In treatment of PFCs with LAMS in patients with DPDS, it is important to replace the LAMS with indwelling plastic stents to minimize PFC recurrence and reduce morbidity. Clinicaltrials.gov no: NCT02422095. | 7/20/2020 | |
| Outcomes of a Structured, Stepwise Approach to Endoscopic Necrosectomy | CONCLUSIONS: By decreasing the number of necrosectomy sessions, a structured, stepwise approach to endoscopic necrosectomy seems to improve procedural efficiency. | 7/14/2020 | |
| A Novel Score to Predict Esophageal Varices in Patients with Compensated Advanced Chronic Liver Disease | CONCLUSION: We propose a new, highly accurate, and easy-to-use scoring system to predict the presence of not only high-risk but any esophageal varices in patients with cACLD. | 7/11/2020 | |
| International consensus guidelines on surveillance for pancreatic cancer in chronic pancreatitis Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with the International Association of Pancreatology, the American Pancreatic Association, the Japan Pancreas Society, and European Pancreatic Club | CONCLUSIONS: Patients with inherited PRSS1 mutations should undergo surveillance for pancreatic cancer, but the best methods for cancer detection need further investigation. | 7/7/2020 | |
| Endoscopic resection of colon dysplasia in patients with inflammatory bowel disease a systematic review and meta-analysis | CONCLUSIONS: Risk of CRC after dysplasia resection in IBD patients appears to be low, supporting the current strategy of resection and surveillance. | 6/28/2020 | |
| Evaluation and Management of Suspected Early Chronic Pancreatitis ECP | PURPOSE OF REVIEW: Chronic pancreatitis in the advanced stages leads to significant health care utilization because of the associated complications. Early-stage diagnosis could prevent the development of these complications by appropriate management. In this article, we reviewed the recent evidence ... | 6/28/2020 | |
| Recent insights on the use of topical steroids in eosinophilic esophagitis | INTRODUCTION: Eosinophilic Esophagitis (EoE) is an immune-mediated, chronic inflammatory disorder of the esophagus. Topical steroids have been used in the management of EoE for over 15 years. However, there are no Food and Drug Administration (FDA) approved drug therapies for EoE. | 6/23/2020 | |
| Randomized controlled trial comparing the Franseen needle with the Fork-tip needle for EUS-guided fine-needle biopsy | CONCLUSIONS: There was no significant difference in the performance of the Franseen needle versus the Fork-tip needle. Both needles achieved a high yield of histologic tissue samples and high diagnostic accuracy. (Clinical trial registration number: NCT03672032.). | 6/12/2020 | |
| Gastrointestinal Bleeding in Patients with Severe SARS-CoV-2 | Gastrointestinal symptoms are common and frequently reported in Coronavirus Disease-2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is unclear if SARS-CoV-2 is associated with increased risk of gastrointestinal bleeding (GIB). Nevertheless, GIB in... | 6/10/2020 | |
| Patterns of endoscopy during COVID-19 pandemic a global survey of interventional inflammatory bowel disease practice | CONCLUSIONS: Cancellation of elective and emergent endoscopy in IBD care during the pandemic was common. Few respondents reported that their patients' disease conditions worsened due to the cancellation of the endoscopy procedure. Most respondents voiced the need for proper PPE during the procedure ... | 6/1/2020 | |
| A Rare Cause of Acute Pancreatitis in a Transgender Female | Acute pancreatitis is defined as an acute inflammation of the pancreas and is most commonly caused by gallstones and alcohol followed by elevated triglycerides and medications. Estrogen as a cause of secondary hypertriglyceridemic pancreatitis is a rare but known phenomenon in females on hormonal th... | 5/15/2020 | |
| Endoscopic ultrasound as a diagnostic and predictive tool in idiopathic acute pancreatitis | CONCLUSIONS: EUS-directed ERCP/cholecystectomy was associated with lower relapse rates in idiopathic acute pancreatitis. Along with age and gallbladder status, it provides predictive information about recurrence likelihood. | 5/9/2020 | |
| A model for the interplay between plastic tradeoffs and evolution in changing environments | Performance tradeoffs are ubiquitous in both ecological and evolutionary modeling, yet they are usually postulated and built into fitness and ecological landscapes. However, tradeoffs depend on genetic background and evolutionary history and can themselves evolve. We present a simple model capable o... | 4/5/2020 | |
| Differences in Age at Onset of Symptoms, and Effects of Genetic Variants, in Patients With Early vs Late-Onset Idiopathic Chronic Pancreatitis in a North American Cohort | CONCLUSIONS: We confirmed previously reported ages at onset of symptoms for EO-ICP and LO-ICP in a North American cohort. We found differences in clinical features among patients with EO-ICP, LO-ICP, and ACP. Almost half of patients with EO-ICP have genetic variants associated with CP, compared with... | 4/3/2020 | |
| Endoscopic ultrasound guided liver biopsy Recent evidence | Liver biopsy (LB) is an essential tool in diagnosing, evaluating and managing various diseases of the liver. As such, histopathological results are critical as they establish or aid in diagnosis, provide information on prognosis, and guide the appropriate selection of medical therapy for patients. I... | 3/29/2020 | |
| Use of Artificial Intelligence to Reduce Radiation Exposure at Fluoroscopy-Guided Endoscopic Procedures | OBJECTIVES: Exposure to ionizing radiation remains a hazard for patients and healthcare providers. We evaluated the utility of an artificial intelligence (AI)-enabled fluoroscopy system to minimize radiation exposure during image-guided endoscopic procedures. | 3/21/2020 | |
| Predictive Factors and Time to Development of Hepatic Decompensation in Patients with Non-alcoholic Fatty Liver Disease | CONCLUSIONS: A significant proportion of patients with NAFLD developed hepatic decompensation. We have provided a simple, objective model to help identify "at-risk" patients. | 3/12/2020 | |
| Effectiveness and safety of EUS-guided choledochoduodenostomy using lumen-apposing metal stents LAMS a systematic review and meta-analysis | CONCLUSION: CDD using LAMS/EC-LAMS is an effective and safe technique for biliary decompression in patients who failed ERCP. Further studies are needed to assess CDD using LAMS as primary treatment modality for biliary obstruction. | 3/7/2020 | |
| Hepatitis E virus infection in liver transplant recipients a descriptive literature review | Hepatitis E virus infection has been recognized as a rising hepatotropic viral infection in the developing countries but overlooked in the developed countries, due to its lower prevalence. However, hepatitis E virus prevalence is on rise in the liver transplant recipients due to immunosuppression, w... | 2/25/2020 | |
| Efficacy of Single-Operator Cholangioscopy-Guided Lithotripsy Compared With Large Balloon Sphincteroplasty in Management of Difficult Bile Duct Stones in a Randomized Trial | CONCLUSIONS: In a randomized trial of patients with difficult bile stones that cannot be cleared by standard maneuvers, SOC-guided lithotripsy leads to duct clearance in a significantly higher proportion of patients than LBS-particularly when stone size exceeds the diameter of the extrahepatic bile ... | 2/15/2020 | |
| Modified Endoscopic Ultrasound Needle to Obtain Histological Core Tissue Samples A Retrospective Analysis | CONCLUSION: EUS-FNB with the modified EUS needle provided histologic tissue cores in the majority of cases and achieved excellent diagnostic accuracy with few needle passes. | 2/6/2020 | |
| Practical guidelines on endoscopic treatment for Crohns disease strictures a consensus statement from the Global Interventional Inflammatory Bowel Disease Group | Stricture formation is a common complication of Crohn's disease, resulting from the disease process, surgery, or drugs. Endoscopic balloon dilation has an important role in the management of strictures, with emerging techniques, such as endoscopic electroincision and stenting, showing promising resu... | 1/20/2020 | |
| Comparative effectiveness of pharmacologic and endoscopic interventions for prevention of post-ERCP pancreatitis a network meta-analysis | Background and study aims While several interventions may decrease risk of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis, it remains unclear whether one strategy is superior to others. The purpose of this study was to compare the effectiveness of pharmacologic and endoscopi... | 1/11/2020 | |
| Proton pump inhibitor in upper gastrointestinal fecal microbiota transplant A systematic review and analysis | CONCLUSIONS: We did not find evidence supporting a clinically significant benefit from routine use of PPIs in FMT protocol. It is possible that the theoretical benefit from improved survival of transplanted microbiota is offset by negative effects on the microbiome. We suggest that routine use of PP... | 12/13/2019 | |
| Safety and efficacy of endoscopic submucosal dissection for rectal neoplasia a multicenter North American experience | Background and aims Rectal lesions traditionally represent the first lesions approached during endoscopic submucosal dissection (ESD) training in the West. We evaluated the safety and efficacy of rectal ESD in North America. Methods This is a multicenter retrospective analysis of rectal ESD between ... | 12/6/2019 | |
| Endoscopic Retrograde Cholangiopancreatography-Related Complications and Their Management Strategies A Scoping Literature Review | Endoscopic retrograde cholangiopancreatography (ERCP) is a well-known procedure with both diagnostic and therapeutic utilities in managing pancreaticobiliary conditions. With the advancements of endoscopic techniques, ERCP has become a relatively safe and effective procedure. However, as ERCP is inc... | 12/4/2019 | |
| Safety of endoscopic retrograde cholangiopancreatography ERCP in pregnancy A systematic review and meta-analysis | CONCLUSIONS: ERCP done by experienced endoscopists is a safe procedure during pregnancy. Radiation-free techniques appear to reduce the rates of nonpregnancy-related complications, but not of fetal and pregnancy-related complications. | 11/21/2019 | |
| Serrated polyp detection rate and advanced adenoma detection rate from a US multicenter cohort | CONCLUSION: A significant percentage of endoscopists have either a low SDR or low AADR despite an adequate ADR, justifying the need for separate SDR and AADR benchmarks. Based on our multicenter cohort, endoscopists with adequate ADRs had a median SDR and median AADR of about 8 % and 9 %, respective... | 11/19/2019 | |
| Comparison of Biliary Stent versus Biliary Sphincterotomy Alone in the Treatment of Bile Leak | CONCLUSION: EBS with or without a biliary stent is highly effective in the management of bile leak. Clinical resolution of the bile leak is quicker with EBS alone, requires fewer interventions, and may cost less. | 11/7/2019 | |
| Endoscopic ultrasound-guided gallbladder drainage, transpapillary drainage, or percutaneous drainage in high risk acute cholecystitis patients a systematic review and comparative meta-analysis | CONCLUSION: EUSGBD demonstrated better clinical success than ETGBD and PCGBD in the management of acute cholecystitis patients at high surgical risk. | 10/24/2019 | |
| Prevalence of colorectal cancer in cryptogenic pyogenic liver abscess patients Do they need screening colonoscopy A systematic review and meta-analysis | CONCLUSION: Our study, albeit limited by heterogeneity, demonstrates that patients with cryptogenic PLA are at a 7-fold risk of having CRC. A screening colonoscopy may be considered in population with cryptogenic PLA, especially if positive for K. pneumoniae. Well-conducted studies are needed to ans... | 10/12/2019 | |
| Statement for gastroesophageal reflux disease after peroral endoscopic myotomy from an international multicenter experience | It has been 10 years since peroral endoscopic myotomy (POEM) was reported for the first time, and POEM has currently become the standard treatment for achalasia and related disorders globally because it is less invasive and has a higher curative effect than conventional therapeutic methods. However,... | 9/28/2019 | |
| Bilateral emvsem unilateral placement of metal stents for inoperable high-grade hilar biliary strictures A systemic review and meta-analysis | CONCLUSION: Bilateral biliary drainage had a lower re-intervention rate as compared to unilateral drainage for high grade inoperable malignant biliary strictures, with no significant difference in technical success, and early or late complication rates. | 9/28/2019 | |
| Two-Dimensional Non-Fermi-Liquid Metals A Solvable Large-N Limit | Significant effort has been devoted to the study of "non-Fermi-liquid" (NFL) metals: gapless conducting systems that lack a quasiparticle description. One class of NFL metals involves a finite density of fermions interacting with soft order parameter fluctuations near a quantum critical point. The p... | 9/17/2019 | |
| Autoimmune hepatitis in patients with human immunodeficiency virus infection A systematic review of the published literature | CONCLUSION: Although rare, but AIH can develop in patients with HIV and physicians should consider it in the differential diagnosis for HIV patients presented with abnormal liver function tests, especially after excluding hepatitis C virus and drug-induced liver injury.Patients with immune deficienc... | 9/14/2019 | |
| Risk of progression in Barretts esophagus indefinite for dysplasia a systematic review and meta-analysis | CONCLUSION: The estimated incidence of HGD and/or EAC and EAC alone in BE-IND is similar to the previously reported progression risk in BE-LGD. Based on these risk estimates, patients with BE-IND should be placed on active endoscopic surveillance. | 8/18/2019 | |
| SpHincterotomy for Acute Recurrent Pancreatitis Randomized Trial Rationale, Methodology, and Potential Implications | CONCLUSIONS: The SHARP trial will determine whether ERCP with miES benefits patients with idiopathic ARP and pancreas divisum. Trial planning has informed the importance of blinded outcome assessors and long-term follow-up. | 8/13/2019 | |
| ASGE guideline for endoscopic full-thickness resection and submucosal tunnel endoscopic resection | With the development of reliable endoscopic closure techniques and tools, endoscopic full-thickness resection (EFTR) is emerging as a therapeutic option for the treatment of subepithelial tumors and epithelial neoplasia with significant fibrosis. EFTR may be categorized as "exposed" and "nonexposed.... | 8/8/2019 | |
| Optimal sequences of same-visit bidirectional endoscopy Systematic review and meta-analysis | CONCLUSION: The present study found that the discomfort score was better in the E-C group. However, there was no difference in polyp and adenoma detection. Therefore, the E-C group is the optimal sequence. | 8/2/2019 | |
| Endoscopic ultrasound-guided liver biopsy using a 22-G fine needle biopsy needle a prospective study | CONCLUSIONS: EUS-LB using a 22-G FNB needle is a safe and viable alternative to the use of larger gauge needles, yielding adequate tissue for evaluation of parenchymal disease in 100 % of the patients. | 8/1/2019 | |
| Optimizing Outcomes of Single-Operator Cholangioscopy-Guided Biopsies Based on a Randomized Trial | CONCLUSIONS: In a prospective comparative study, we found that centers without onsite cytopathology support that analyze 3 single-operator cholangioscopy-guided biopsies of a biliary stricture and process the specimens offsite make the correct diagnosis for 90% of cases. ClinicalTrials.gov, Number: ... | 7/28/2019 | |
| Devices for endoscopic hemostasis of nonvariceal GI bleeding with videos | CONCLUSIONS: Endoscopic evaluation and treatment remains a cornerstone in the management of nonvariceal upper- and lower-GI bleeding. A variety of devices is available for hemostasis of bleeding lesions in the GI tract. Other than injection therapy, which should not be used as monotherapy, there are... | 7/24/2019 | |
| Quantum-Induced Symmetry Breaking in the Deuterated Dihydroanthracenyl Radical | The hydrogen-atom adduct with anthracene, 9-dihydroanthracenyl radical (C(14)H(11)), and its deuterated analogue have been identified by laser spectroscopy coupled to time-of-flight mass spectrometry, supported by time-dependent density functional theory calculations. The electronic spectrum of 9-di... | 7/17/2019 | |
| Fine-needle biopsy is superior to fine-needle aspiration of suspected gastrointestinal stromal tumors a large multicenter study | Background and study aims There are numerous studies published on the diagnostic yield of the new fine-needle biopsy (FNB) needles in pancreas masses. However, there are limited studies in suspected gastrointestinal stromal tumors (GIST lesions). The aim of this study was to evaluate the diagnostic... | 7/16/2019 | |
| Safety and efficacy of combined antegrade and retrograde endoscopic dilation for complete esophageal obstruction a systematic review and meta-analysis | CONCLUSIONS: The CARD procedure for CEO has a high technical success rate, but also a high rate of repeat dilations. Given its complexity and associated adverse events, this procedure should be restricted to centers with a high level of expertise. | 7/3/2019 | |
| Comparison of Franseen and fork-tip needles for EUS-guided fine-needle biopsy of solid mass lesions A systematic review and meta-analysis | Franseen-tip and Fork-tip needles have been widely used in EUS guided fine-needle biopsy (FNB) of solid organs. There is conflicting data on the performance of these needles and unanswered questions on the ideal number of needle-passes and the requirement of an onsite cytopathologist (ROSE). We cond... | 6/29/2019 | |
| Superiority of endoscopic interventions over minimally invasive surgery for infected necrotizing pancreatitis meta-analysis of randomized trials | CONCLUSIONS: An endoscopy-based treatment approach, as compared to minimally invasive surgery, significantly reduces complications in patients with infected necrotizing pancreatitis. | 6/21/2019 | |
| Pre-operative biliary drainage is associated with shortened survival time in patients with cholangiocarcinoma | CONCLUSIONS: PBD appears negative impact on long-term survival in patients with potentially resectable CCA and should be avoided if possible. | 6/21/2019 | |
| Acute Pancreatitis Task Force on Quality Development of Quality Indicators for Acute Pancreatitis Management | INTRODUCTION: Detailed recommendations and guidelines for acute pancreatitis (AP) management currently exist. However, quality indicators (QIs) are required to measure performance in health care. The goal of the Acute Pancreatitis Task Force on Quality was to formally develop QIs for the management ... | 6/18/2019 | |
| Endoscopic simulators | CONCLUSIONS: Simulation training is a promising modality that may aid in endoscopic education. However, for widespread incorporation of simulators into gastroenterology training programs to occur, simulators must show a sustained advantage over traditional mentored teaching in a cost-effective manne... | 5/25/2019 | |
| Adverse events with lumen-apposing metal stents in endoscopic gallbladder drainage A systematic review and meta-analysis | CONCLUSION: We report an overall AE rate of 13% with LAMS in EUS-GBD. Early AE risk appears to be 6.5% and delayed AE risk appears to be 8%. Our results are analyzed out of good-quality studies, with minimal to zero heterogeneity. | 5/23/2019 | |
| Advances in the diagnosis and surveillance of Barretts esophagus with videos | CONCLUSION: Several technologies discussed in this document may improve dysplasia detection in BE in a wide-field manner. Moreover, the addition of different biomarkers may aid in enhanced risk stratification to optimize approaches to surveillance or treatment for patients with BE. | 5/23/2019 | |
| Lumen-apposing metal stents for endoscopic ultrasonography-guided interventions | Lumen-apposing metal stents (LAMS) are integrated in a single-step delivery platform and can be deployed under endoscopic ultrasound-guidance for the drainage of intra-abdominal fluid collections, decompression of obstructed ductal systems, establishment of anastomosis or creation of fistulous tract... | 5/4/2019 | |
| Endosonographer-driven dynamic telecytopathology of pancreatic lesions-a pilot study | CONCLUSION: An endosonographer with limited training can examine for specimen adequacy, transmit images, and demonstrate representative cell groups. Larger studies are required though preliminary results are encouraging. | 5/3/2019 | |
| Lumen apposing metal stents in drainage of pancreatic walled-off necrosis, are they any better than plastic stents A systematic review and meta-analysis of studies published since the revised Atlanta classification of pancreatic fluid collections | Lumen-apposing metal stents (LAMS) are increasingly being used in the drainage of pancreatic walled-off necrosis (WON). Best choice of stent is subject to argument, and studies are varied in the reported outcomes between LAMS and plastic stents (PS) to this end. We conducted a comprehensive search o... | 4/23/2019 | |
| Prophylactic pre-esophagogastroduodenoscopy tracheal intubation in patients with upper gastrointestinal bleeding | The indications for endotracheal intubation (ETI) during an esophagogastroduodenoscopy (EGD) procedure remain unclear. This study performed a descriptive analysis of patients who underwent prophylactic tracheal intubation during or before an EGD to prevent pulmonary aspiration. We selected patients ... | 4/9/2019 | |
| Endoscopic detection and resection of dysplasia in inflammatory bowel disease-techniques with videos | CONCLUSIONS: In this review, we discuss the various techniques for endoscopic resection of dysplasia in patients with inflammatory bowel disease. Further research is required to determine the optimal approach to diagnosis and management of dysplasia in patients with inflammatory bowel disease. | 3/12/2019 | |
| Outcomes of use of electromagnetic guidance with responsive insertion technology RIT during colonoscopy a prospective randomized controlled trial | Background and study aims Colonoscopy can be technically challenging and cause discomfort in patients. The integrated Scope Guide assist is built in to show that with its use outcomes are improved during colonoscopy. We aimed to test the usefulness of the Magnetic Scope Guide Assist (ScopeGuide ) wi... | 2/2/2019 | |
| Biliary interventions using single-operator cholangioscopy | Cholangioscopy provides an opportunity to directly visualize the bile duct for diagnosing biliary lesions and for therapeutic interventions. Although there are different cholangioscopy techniques available, single-operator cholangioscopy has gained widespread acceptance as the standard technique for... | 1/29/2019 | |
| Efficacy and Safety of Endoscopic Ultrasound-guided Choledochoduodenostomy A Systematic Review and Meta-Analysis | CONCLUSIONS: On the basis of our analysis EUS-CDD has an adverse event risk of 13.4%, which is lowest reported in literature so far. Reported adverse rates appeared to be lower with the use of lumen-apposing metal stent, except for perforation. | 1/26/2019 | |
| Oesophageal Stents for Potentially Curable Oesophageal Cancer - A Bridge to Surgery | For oesophageal cancer patients with potentially curative disease, treatment usually comprises neoadjuvant chemoradiotherapy followed by surgery. Several methods are currently used for nutritional support while patients are undergoing neoadjuvant treatment but these do not relieve dysphagia. Stentin... | 1/25/2019 | |
| An Endoscopic Transluminal Approach, Compared With Minimally Invasive Surgery, Reduces Complications and Costs for Patients With Necrotizing Pancreatitis | CONCLUSIONS: In a randomized trial of 66 patients, an endoscopic transluminal approach for infected necrotizing pancreatitis, compared with minimally invasive surgery, significantly reduced major complications, lowered costs, and increased quality of life. Clinicaltrials.gov no: NCT02084537. | 11/20/2018 | |
| Colorectal cancer resection rates in patients with inflammatory bowel disease a population-based study | CONCLUSIONS: CRC resection rates among IBD patients have continued to decrease annually from 1995 to 2012. There is a population-level decrease in resection of both proximal and distal CRC reflecting a decreasing incidence of IBD-related CRC incidence in the USA. | 11/16/2018 | |
| Biliary and pancreatic lithotripsy devices | CONCLUSIONS: Several lithotripsy techniques have been described that vary with respect to ease of use, generalizability, and cost. Overall, lithotripsy is a safe and effective treatment for difficult biliary and pancreatic duct stones. | 11/8/2018 | |
| Role of interventional inflammatory bowel disease in the era of biologic therapy a position statement from the Global Interventional IBD Group | Interventional (or therapeutic) inflammatory bowel disease (IBD) endoscopy has an expanding role in the treatment of disease and surgical adverse events. Endoscopic therapy has been explored and used in the management of strictures, fistulas/abscesses, colitis-associated neoplasia, postsurgical acut... | 10/27/2018 | |
| Jet-Cooled Spectroscopy of ortho-Hydroxycyclohexadienyl Radicals | The electronic spectra of the ortho-hydroxycyclohexadienyl radical have been observed following the supersonic expansion of the electric discharge products of phenol and water. Hydrogen atoms, split from water, add to the phenol ring at the ortho position, generating syn and anti rotamers with respe... | 10/24/2018 | |
| Periampullary Diverticula and ERCP Outcomes A Systematic Review and Meta-Analysis | CONCLUSION: ERCP is technically feasible and increasingly successful when performed by experts in the presence of PAD. The risk of complications such as PEP, bleeding, perforation and cholangitis does not differ between ERCP done in patients with and without PAD. | 10/8/2018 | |
| In memoriam Fine-needle aspiration, birth Fine-needle biopsy The changing trend in endoscopic ultrasound-guided tissue acquisition | CONCLUSION: Given these promising findings, in the future, EUS-guided FNB will likely be the preferred technique for sampling of solid mass lesions. | 9/27/2018 | |
| Utility of rapid onsite evaluation of touch imprint cytology from endoscopic and cholangioscopic forceps biopsy sampling with video | CONCLUSIONS: By establishing a rapid onsite diagnosis, ROSE-TIC expedites decision-making on patient management. Prospective studies are needed to confirm these preliminary findings. | 9/9/2018 | |
| Evaluation and management of acute pancreatitis in Spain | INTRODUCTION: The aim of this systematic review is to summarize epidemiological data and areas of future acute pancreatitis research in Spain. | 8/29/2018 | |
| EUS-guided celiac ganglion radiofrequency ablation versus celiac plexus neurolysis for palliation of pain in pancreatic cancer a randomized controlled trial with videos | CONCLUSIONS: Compared with EUS-CPN, EUS-RFA provided more pain relief and improved the quality of life for patients with pancreatic cancer. (Clinical trials registration number: NCT03152487.). | 8/19/2018 | |
| Nutrition and Inflammatory Biomarkers in Chronic Pancreatitis Patients | CONCLUSIONS: CP patients demonstrated lower levels of selected nutrition and bone metabolism biomarkers than controls. Diabetes and alcohol did not impact biomarkers. Vitamin supplements and pancreatic enzyme replacement therapy improved nutrition biomarkers in CP patients. | 8/14/2018 | |
| Cholangiocarcinoma Presenting as Linitis Plastica with Unusual Metastases to the Psoas Muscle and Urinary Bladder | Cholangiocarcinoma offers poor prognosis. Infrequent sites of metastasis are poorly described and often diagnostically delayed or missed. Bile duct brush cytologies provide poor diagnostic sensitivity/specificity. We present an unusual case of cholangiocarcinoma in a 34-year-old woman with rare dist... | 7/25/2018 | |
| Mass spectrometry-assisted venom profiling of Hypnale hypnale found in the Western Ghats of India incorporating de novo sequencing approaches | Hypnale hypnale (hump-nosed pit viper) is considered to be one among the medically important venomous snake species of India and Sri Lanka. In the present study, venom proteome profiling of a single Hypnale hypnale from Western Ghats of India was achieved using SDS-PAGE based protein separation foll... | 7/11/2018 | |
| Incidence of Venous Air Embolism During Endoscopic Retrograde Cholangiopancreatography | CONCLUSIONS: The high incidence of VAE highlights the need for practitioners to be aware of this potentially serious event. Use of PDU can aid in the detection of VAE during ERCP and should be considered especially during high-risk therapeutic procedures. Detection may allow appropriate intervention... | 6/23/2018 | |
| Role of Cholecystectomy After Endoscopic Sphincterotomy in the Management of Choledocholithiasis in High-risk Patients A Systematic Review and Meta-Analysis | CONCLUSIONS: Although we found no difference in mortality between the 2 strategies after ES, laparoscopic cholecystectomy should be recommended as it is associated with lower rates of subsequent recurrent cholecystitis, cholangitis, and biliary colic down the road even in high-risk surgical patients... | 6/19/2018 | |
| Non-superiority of lumen-apposing metal stents over plastic stents for drainage of walled-off necrosis in a randomised trial | CONCLUSION: Except for procedure duration, there was no significant difference in treatment outcomes between LAMS and plastic stents. To minimise adverse events with LAMS, patients should undergo follow-up imaging and stent removal at 3 weeks if WON has resolved. | 6/3/2018 | |
| International consensus statements on early chronic Pancreatitis Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with The International Association of Pancreatology, American Pancreatic Association, Japan Pancreas Society, PancreasFest Working Group and European Pancreatic Club | CONCLUSIONS: Morphology based diagnosis of Early CP is not possible without additional information. New approaches to the accurate diagnosis of Early CP will require a mechanistic definition that considers risk factors, biomarkers, clinical context and new models of disease. Such a definition will r... | 5/26/2018 | |
| Digital pancreatoscopy in the evaluation of main duct intraductal papillary mucinous neoplasm a multicenter study | CONCLUSION: Digital pancreatoscopy should be considered in the diagnostic algorithm of MD-IPMN in patients with a diffusely dilated pancreatic duct and without any focal lesions seen on cross-sectional imaging or EUS. | 4/27/2018 | |
| Stent placement by EUS or ERCP for primary biliary decompression in pancreatic cancer a randomized trial with videos | CONCLUSIONS: Given the similar rates of adverse events and treatment outcomes in this randomized trial, EUS-BD is a practical alternative to ERCP for primary biliary decompression in pancreatic cancer. (Clinical trial registration number: NCT03054987.). | 3/26/2018 | |
| Endoscopic Ultrasound-guided Specimen Collection and Evaluation Techniques Affect Diagnostic Accuracy | CONCLUSION: In a randomized trial of patients undergoing EUS-FNA for pancreatic masses, samples collected with 22-gauge vs 25-gauge needles performed equally well for offsite specimen evaluation. Use of suction appears to increase number of passes needed and specimen bloodiness. Specimen collection ... | 3/15/2018 | |
| How the Experts Do It Step-by-Step Guide | Lumen-apposing metal stents are integrated in a single-step delivery system for draining intra-abdominal fluid collections. The theoretic advantage of lumen-apposing stents is the ability to approximate the wall of the drained cavity or organ to the gastrointestinal tract lumen. The use of lumen-app... | 3/10/2018 | |
| Pure Squamous Cell Carcinoma of the Gallbladder Masquerading as a Hepatic Mass | Gallbladder (GB) carcinomas are adenocarcinomas (AC) in the majority of cases. Adenosquamous carcinoma (ASC) and pure squamous cell carcinoma (SCC) of the gallbladder are rarely encountered and comprise 1-3% of gallbladder cancer cases. Pure squamous cell carcinoma of the gallbladder is rarer with l... | 3/9/2018 | |
| Discovery and Validation of Circulating Biomarkers of Colorectal Adenoma by High-Depth Small RNA Sequencing | Purpose: Colorectal cancer is the third most common cancer worldwide, causing approximately 700,000 deaths each year. The majority of colorectal cancers begin as adenomas. Definitive screening for colorectal adenomas is currently accomplished through colonoscopy but, owing largely to costs and invas... | 3/2/2018 | |
| Association of Pulsatility with Gastrointestinal Bleeding in a Cohort of HeartMate II Recipients | Gastrointestinal bleeding (GIB) is common in patients with continuous-flow left ventricular assist devices (CF-LVADs) possibly because of changes in blood flow. We aimed to test the hypothesis that a low pulsatility index (PI) is associated with an increased hazard of overt GIB in patients with CF-L... | 3/1/2018 | |
| Utility of endoscopic ultrasound and endoscopy in diagnosis and management of hepatocellular carcinoma and its complications What does endoscopic ultrasonography offer above and beyond conventional cross-sectional imaging | Hepatocellular carcinoma constitutes over 90% of the primary liver tumors, the rest being cholangiocarcinoma. It has an insidious presentation, which is responsible for the delayed presentation. Hence, the management strategy relies on screening to diagnose it an early stage for curative resection a... | 2/23/2018 | |
| Case series on multimodal endoscopic therapy for gastric antral vascular ectasia, a tertiary center experience | CONCLUSION: Patients with nodular variant GAVE required multimodal approach more frequently than non-nodular variants. Patients responded well to multimodal therapy and saw decrease in transfusion rates and increase in Hb concentrations. Our findings suggest a multimodal approach may be beneficial i... | 1/30/2018 | |
| Interconversion of Methyltropyl and Xylyl Radicals A Pathway Unavailable to the Benzyl-Tropyl Rearrangement | The products of an electrical discharge containing toluene are interrogated using resonance-enhanced multiphoton ionization and laser-induced fluorescence spectroscopies. A previously unreported electronic spectrum recorded at m/z = 105, with a putative origin band at 26053 cm^(-1), is assigned to m... | 1/16/2018 | |
| Randomized trial comparing the Franseen and Fork-tip needles for EUS-guided fine-needle biopsy sampling of solid pancreatic mass lesions | CONCLUSIONS: There was no significant difference between Franseen and Fork-tip needles in yielding histologic tissue. Given their ability to yield diagnostic cell block in greater than 90% of patients, the new-generation fine-needle biopsy needles may obviate the need for ROSE. (Clinical trial regis... | 1/7/2018 | |
| Endoscopic sutured gastroplasty procedure evolution from first-in-man cases through current technique | CONCLUSIONS: Following a methodical procedure development phase, ESG demonstrated safety and short-term efficacy in this trial. The procedure also achieved meaningful weight loss during the follow-up period. | 10/28/2017 | |
| Endoscopic Evaluation and Management of Gastric Stromal Tumors | Purpose of Review Gastrointestinal stromal tumors (GISTs) are both relatively common. Management of these lesions has been challenging with emerging interest in the endoscopic approach for both diagnostic and therapeutic interventions. Recent Findings Although these can be visualized on CT scan, end... | 10/28/2017 | |
| Endoscopic Dissolution of Gastric Lipoma with Argon Plasma Coagulation | A 47-year-old patient presented from outside the hospital for evaluation of iron deficiency anemia (IDA). The endoscopic workup suggested a gastric antral subepithelial lesion with an overlying arteriovenous malformation (AVM). Endoscopic ultrasound (EUS) revealed the lesion to be a lipoma. Given th... | 10/5/2017 | |
| Advances and Future Directions in the Treatment of Hepatocellular Carcinoma | Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Liver transplant is considered the gold standard for curative therapy for HCC when patients are not candidates for surgical resection or ablation. Because a subset of patients with HCC have a survival rate... | 9/5/2017 | |
| Beyond Abdominal Pain Pain Beliefs, Pain Affect, and Distress as Determinants of Quality of Life in Patients With Chronic Pancreatitis | CONCLUSIONS: The significant predictors of QOL impairment in CP are pain intensity and perceived self-blame for pain. Further research is needed to elucidate this relationship while also evaluating the effectiveness of systematic modification of these variables in an attempt to improve pain and QOL ... | 9/1/2017 | |
| New approach to decrease post-ERCP adverse events in patients with primary sclerosing cholangitis | CONCLUSION: Biliary aspiration and avoidance of stenting approach after dilation of strictures during ERCP in PSC patients appears to be associated with decreased risk of cholangitis and overall AEs. Future prospective randomized controlled trials are needed to validate our observation. | 8/10/2017 | |
| Editorial Management of the Small Asymptomatic Pancreatic Cyst Somehow Along the Way We Forgot About the Patient | The incidentally identified pancreatic cyst is an increasing burden for both physicians and patients alike. Although we recognize that most of these lesions are benign and may not progress, a subset of these lesions are premalignant, may have frank cancer, and may progress over time. Most occur in o... | 8/3/2017 | |
| Endoscopic Stents for the Biliary Tree and Pancreas | OPINION STATEMENT: PURPOSE OF REVIEW: To review the recently published literature on biliary and pancreatic stents. | 7/21/2017 | |
| Drugs in Development for Hepatitis B | With high morbidity and mortality worldwide, there is great interest in effective therapies for chronic hepatitis B (CHB) virus. There are currently several dozen investigational agents being developed for treatment of CHB. They can be broadly divided into two categories: (1) direct-acting antiviral... | 6/30/2017 | |
| Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA A Report of the North American Pancreas Study NAPS Group | CONCLUSION: Our data validate the current epidemiologic trends in CP. Alcohol remains the most common physician-defined etiology, while smoking was the most commonly identified TIGAR-O risk factor. Identification of multiple risk factors suggests CP to be a complex disease. | 6/11/2017 | |
| Systematic review and meta-analysis to determine the impact of iron depletion in dysmetabolic iron overload syndrome and non-alcoholic fatty liver disease | CONCLUSIONS: Phlebotomy does not bring about significant improvement in indices of insulin resistance, liver enzymes, or liver histology in patients with DIOS and/or NAFLD compared to lifestyle changes alone. Current evidence does not support the use of phlebotomy in patients with DIOS or NAFLD. | 6/9/2017 | |
| Safety of ERCP in patients with liver cirrhosis a national database study | Background and aims Given the limited data on the safety of endoscopic retrograde cholangiopancreatography (ERCP) in patients with liver cirrhosis, we attempted to evaluate this question using a large national database. Methods We conducted a matched case - control study using the 2010 National Inpa... | 4/11/2017 | |
| Locoregional Therapy With Curative Intent Versus Primary Liver Transplant for Hepatocellular Carcinoma Systematic Review and Meta-Analysis | CONCLUSIONS: CLRT-SLT may be offered as first-line therapy to patients with HCC and well-compensated cirrhosis instead of primary LT because it may lead to better utilization of donor liver. However, a large proportion of patients with HCC recurrence after CLRT may not be candidates for SLT. | 3/11/2017 | |
| Nonsupersymmetric Dualities from Mirror Symmetry | We study supersymmetry breaking perturbations of the simplest dual pair of (2+1)-dimensional N=2 supersymmetric field theories-the free chiral multiplet and N=2 super QED with a single flavor. We find dual descriptions of a phase diagram containing four distinct massive phases. The equivalence of th... | 1/21/2017 | |
| Prophylactic rectal indomethacin may be ineffective for preventing post-endoscopic retrograde cholangiopancreatography pancreatitis in general patients A meta-analysis | CONCLUSION: In a contemporary meta-analysis of available randomized controlled trials of consecutive patients undergoing ERCP, rectal indomethacin did not show significant prevention effect of post-ERCP pancreatitis. | 12/4/2016 | |
| Patients presenting for colonoscopy A great opportunity to screen for sleep apnea | CONCLUSION: Risk for OSA is extremely common in a population presenting for a routine colonoscopy, and screening at the time of a colonoscopy offers an excellent opportunity to identify these patients. | 12/3/2016 | |
| Endoscopic ultrasonography-guided biopsy using a Franseen needle design Initial assessment | CONCLUSION: Preliminary data suggest that the Franseen needle yields diagnostic material for ROSE and histology in >95% of patients. | 11/24/2016 | |
| Overuse and Misperceptions of Nonsteroidal Anti-inflammatory Drugs in the United States | CONCLUSIONS: NSAIDs are widely used and often used in a manner that increases the risk of serious side effects. Sufficient knowledge and understanding of NSAIDs is lacking and educational interventions directed to consumers and physicians are needed. | 11/21/2016 | |
| Impact of Disconnected Pancreatic Duct Syndrome on the Endoscopic Management of Pancreatic Fluid Collections | CONCLUSIONS: DPDS has a significant effect on endoscopic management of PFCs as more patients required hybrid treatment, reinterventions, and rescue surgery for achieving optimal clinical outcomes. | 11/17/2016 | |
| Predictors of Successful Downstaging of Hepatocellular Carcinoma Outside Milan Criteria | CONCLUSIONS: Total tumor volume is a good predictor of successful downstaging of HCC. Patients with TTV less than 200 cm may be considered good candidates for downstaging. Further studies with larger cohort of patients are needed to validate this approach in patients with HCC outside Milan. | 10/26/2016 | |
| Airway observations during upper endoscopy predicting obstructive sleep apnea | CONCLUSIONS: The results of our pilot study represent preliminary data regarding the use of upper endoscopy as a potential tool to evaluate patients for obstructive sleep apnea. | 10/7/2016 | |
| Systematic review with meta-analysis endoscopic retrograde cholangiopancreatography-based modalities for the diagnosis of cholangiocarcinoma in primary sclerosing cholangitis | CONCLUSIONS: Single-operator cholangioscopy with targeted biopsies appears to be the most accurate ERCP-based modality for diagnosing cholangiocarcinoma in primary sclerosing cholangitis. However, future large, well-designed comparative diagnostic studies are warranted to validate these findings. | 10/4/2016 | |
| Two-Person Technique of Peroral Endoscopic Myotomy for Achalasia with an Advanced Endoscopist and a Thoracic Surgeon Initial Experience | Background and Aims. We initiated peroral endoscopic myotomy (POEM) utilizing a two-person technique with combination of an advanced endoscopist and a thoracic surgeon with complementary skills. Our aim was to determine the feasibility and outcomes in initial 20 patients. Methods. In this observatio... | 9/16/2016 | |
| Cost utility of ERCP-based modalities for the diagnosis of cholangiocarcinoma in primary sclerosing cholangitis | CONCLUSIONS: SOC with biopsy sampling is the most cost-effective diagnostic modality for CCA in PSC strictures. | 9/4/2016 | |
| Efficacy and safety of endoscopic mucosal resection of non-ampullary duodenal polyps a systematic review | CONCLUSION: EMR appears to be a safe and effective therapeutic option for management of sporadic non-ampullary duodenal polyps. Long-term endoscopic surveillance is required to manage and treat recurrent disease. | 8/25/2016 | |
| Translational and clinical perspectives on sphincter of Oddi dysfunction | Sphincter of Oddi dysfunction is a complex pathophysiologic entity that is associated with significant morbidity causing abdominal pain, nausea, and vomiting. The purpose of this review is to describe the anatomy and physiology of the sphincter of Oddi, to understand the pathologic mechanisms though... | 8/25/2016 | |
| Endoscopic Treatment of Walled-off Necrosis in Children Clinical Experience and Treatment Outcomes | CONCLUSIONS: Endoscopic treatment is effective, safe, and when available should be the first-line modality for the management of WON in children. | 8/23/2016 | |
| Pattern of Inflammation on Surveillance Colonoscopy Does Not Predict Development of Colitis-associated Neoplasia | CONCLUSIONS: In patients with UC, colonoscopic features especially on standard-definition white-light colonoscopy did not appear to reliably predict the development of colitis-associated neoplasia. This will leave room for image-enhanced endoscopy technology and molecular markers for the early and a... | 8/20/2016 | |
| EUS correlates of disconnected pancreatic duct syndrome in walled-off necrosis | CONCLUSIONS: We report EUS findings indicating the presence of DPDS. These findings may have significant clinical implications for the management of patients with WON. | 8/20/2016 | |
| Graft Versus Host Disease After Liver Transplantation in Adults A Case series, Review of Literature, and an Approach to Management | CONCLUSIONS: Age older than 50 years and hepatocellular carcinoma appear to be risk factors for GVHD. Hepatitis C may be protective. High-dose steroids and calcineurin inhibitors are ineffective in the treatment of GVHD after LT. CD2-blockers and TNF-α antagonists appear promising. We propose a diag... | 8/7/2016 | |
| Role of ERCP in Patients With Idiopathic Recurrent Acute Pancreatitis | Recurrent acute pancreatitis (RAP) is defined based on the occurrence of two or more episodes of acute pancreatitis. RAP is differentiated from chronic pancreatitis based on the presence of a normal morphological appearance of the pancreas between episodes. RAP can be due to a variety of etiologies ... | 7/3/2016 | |
| Melanoma Metastasizing to the Small Intestine A Case Report Illustrating Symptomatic and Asymptomatic Involvement | Symptomatic gastrointestinal (GI) involvement of melanoma is rare, however, it is a frequent autopsy finding in patients with primary cutaneous melanoma. We present a case of metastatic cutaneous melanoma with initial asymptomatic jejunal involvement as found on a positron emission tomography (PET) ... | 6/23/2016 | |
| Prospective Endoscopic Ultrasound-Based Approach to the Evaluation of Idiopathic Pancreatitis Causes, Response to Therapy, and Long-term Outcome | CONCLUSIONS: Following a single idiopathic attack of pancreatitis and a negative EUS examination, relapse was infrequent. Despite endoscopic therapy, patients with multiple attacks, especially those attributed to pancreas divisum and SOD, had high rates of recurrence. EUS may be a useful, minimally ... | 6/22/2016 | |
| Rhinoscleroma with Pharyngolaryngeal Involvement Caused by Klebsiella ozaenae | Rhinoscleroma is a chronic, slowly progressive granulomatous bacterial infection that is endemic to the tropical world, namely, Central America and Africa. It is occasionally seen in the United States of America (USA). It predominately affects the nasal mucosa but can also involve the rest of the up... | 6/14/2016 | |
| Lumen-apposing metal stents for drainage of pancreatic fluid collections When and for whom | CONCLUSIONS: Although there is no difference in clinical outcomes, treating pseudocysts using plastic stents is less expensive. It is also possible that the short procedural duration is a surrogate marker for procedural complexity and this may drive the use of LAMS in sicker patients. | 5/21/2016 | |
| Prospective Evaluation of the Clinical Features of Choledocholithiasis Focus on Abdominal Pain | CONCLUSIONS: In our study, choledocholithiasis had a characteristic pattern of constant epigastric pain radiating to the back that was associated with nausea. A prior episode was common. The most common laboratory abnormality was transaminase elevation, and the most common imaging finding was common... | 5/3/2016 | |
| Endoscopic balloon dilation in the management of strictures in Crohns disease a systematic review and meta-analysis of non-randomized trials | CONCLUSIONS: EBD appears to be a safe alternative for surgery in the management of Crohn's strictures. Stricture length <4 cm treated with EBD is associated with a significantly decreased risk of surgical intervention. | 4/30/2016 | |
| Intraprocedural increase in heart rate during EUS-guided celiac plexus neurolysis Clinically relevant or just a physiologic change | CONCLUSIONS: Because patients with an increase in intraprocedural heart rate experienced significant improvement in pain and quality of life components, this observation must be further explored in order to improve the technique and outcomes of EUS-CPN. | 4/7/2016 | |
| Improving the diagnostic yield of single-operator cholangioscopy-guided biopsy of indeterminate biliary strictures ROSE to the rescue with video | CONCLUSIONS: Preliminary data suggest that the diagnostic outcomes of SOC-guided biopsies in IDBSs can be significantly improved by using ROSE-TIC. This technique also may benefit centers that rely mainly on fluoroscopy-guided intraductal biopsies. | 4/7/2016 | |
| Lessons Learned from Traditional NOTES A Historical Perspective | The idea of natural orifice surgery was conceived by Kantsevoy and Kalloo in the late 1990s. A group of surgeons formed the Apollo Group in 1997. Their vision and mission were to impact the practice of therapeutic endoscopy through innovation in techniques and technologies. The concept of natural or... | 4/3/2016 | |
| Role of Endoscopic Ultrasonography and Endoscopic Retrograde Cholangiopancreatography in the Clinical Assessment of Pancreatic Neoplasms | Accurate diagnosis and staging of pancreatic neoplasms is essential for surgical planning and identification of locally advanced and metastatic disease that is incurable by surgery. The ability to position the endoscopic ultrasonography (EUS) transducer close to the pancreas combined with the use of... | 3/26/2016 | |
| Endoscopic ultrasonography is not required for staging malignant esophageal strictures that preclude the passage of a diagnostic gastroscope | CONCLUSION: Routine EUS examination may not be required in all patients with ECA as the inability to advance a diagnostic gastroscope past a malignant stricture correlates 100% with locally advanced disease on EUS. | 3/23/2016 | |
| Digital, single-operator cholangiopancreatoscopy in the diagnosis and management of pancreatobiliary disorders a multicenter clinical experience with video | CONCLUSIONS: SOC has become an integral part of the ERCP armamentarium and has high accuracy in the evaluation of indeterminate biliary strictures. Complete stone clearance was achieved in all but 1 patient with challenging biliary or pancreatic duct stones. ( | 3/21/2016 | |
| Clinical Profile, Etiology, and Treatment of Chronic Pancreatitis in North American Women Analysis of a Large Multicenter Cohort | CONCLUSIONS: Most CP cases in women are from nonalcoholic etiologies. In contrast to many other chronic diseases, clinical phenotype of CP is determined by the disease and is independent of sex. | 3/12/2016 | |
| Impact of Concurrent Non-IBD Immunological Diseases on the Outcome of Primary Sclerosing Cholangitis | CONCLUSIONS: The association of NID in patients with PSC did not seem to affect the need for liver transplantation or transplantation-free survival. The findings suggest that the increased load of autoimmunity, including the presence of IBD or NID, has a minimum impact on the disease outcome of PSC. | 3/8/2016 | |
| Hydrogen-atom attack on phenol and toluene is ortho-directed | The reaction of H + phenol and H/D + toluene has been studied in a supersonic expansion after electric discharge. The (1 + 1') resonance-enhanced multiphoton ionization (REMPI) spectra of the reaction products, at m/z = parent + 1, or parent + 2 amu, were measured by scanning the first (resonance) l... | 3/8/2016 | |
| Oxalate Concentrations in Human Gastrointestinal Fluid | CONCLUSIONS: Our results suggest that some degree of oxalate secretion in the small intestine may occur in the fasted state while this is less likely in the stomach. Further studies are warranted to provide definitive evidence of gastrointestinal secretion of oxalate. | 3/5/2016 | |
| Safety of Ascitic Paracentesis in Patients with Budd-Chiari Syndrome on Oral Anticoagulation and Elevated International Normalized Ratio | CONCLUSIONS: Ascitic paracentesis in patients with BCS on anticoagulation is safe without an increased risk of abdominal wall bleeding or hemoperitoneum. Normal or high FVIII and platelet levels likely mitigate against bleeding risks. | 2/23/2016 | |
| ASGE Technology Committee systematic review and meta-analysis assessing the ASGE Preservation and Incorporation of Valuable Endoscopic Innovations thresholds for adopting real-time imaging-assisted endoscopic targeted biopsy during endoscopic surveillance of Barretts esophagus | CONCLUSIONS: Our meta-analysis indicates that targeted biopsies with acetic acid chromoendoscopy, electronic chromoendoscopy by using narrow-band imaging, and endoscope-based CLE meet the thresholds set by the ASGE PIVI, at least when performed by endoscopists with expertise in advanced imaging tech... | 2/15/2016 | |
| Therapeutic and interventional endoscopy for gastrointestinal bleeding | CONCLUSIONS: This is the first review paper dedicated to endoscopic therapy for bleeding involving any part of the luminal GI tract (i.e., esophagus, stomach, small bowel, and colon). Modern endoscopy permits the investigation and treatment of the majority of conditions affecting the entire hollow G... | 1/28/2016 | |
| Endoscopy in the Diagnosis and Management of Complications of Inflammatory Bowel Disease | The role of endoscopy in inflammatory bowel disease (IBD) has grown over the last decade in both diagnostic and therapeutic realms. It aids in the initial diagnosis of the disease and also in the assessment of the extent and severity of disease. IBD is associated with development of multiple complic... | 12/31/2015 | |
| Topical steroids in eosinophilic esophagitis Systematic review and meta-analysis of placebo-controlled randomized clinical trials | CONCLUSIONS: Topical corticosteroids seem to be effective in inducing histological remission but may not have similar significant impact in improving clinical symptoms of EoE. Studies with large sample size are needed to uniformly validate symptom improvement in EoE. | 12/25/2015 | |
| An evaluation of factors influencing the assessment time in a nurse practitioner-led anaesthetic pre-operative assessment clinic | Elective patients undergoing anaesthetic pre-operative assessment are usually allocated the same period of time with a nurse practitioner, leading to potential inefficiencies in patient flow through the clinic. We prospectively collected data on 8519 patients attending a pre-operative assessment cli... | 12/20/2015 | |
| Mechanism, assessment and management of pain in chronic pancreatitis Recommendations of a multidisciplinary study group | CONCLUSIONS: Progress is occurring in pain biology and treatment options, but pain in patients with CP remains a major problem that is inadequately understood, measured and managed. The growing body of information needs to be translated into more effective clinical care. | 12/2/2015 | |
| A meta-analysis comparing ProCore and standard fine-needle aspiration needles for endoscopic ultrasound-guided tissue acquisition | CONCLUSIONS: Current data do not demonstrate a significant difference between the ProCore and standard FNA needles for sample adequacy, diagnostic accuracy or acquisition of a core specimen. However, the ProCore needle establishes the diagnosis with fewer passes. | 11/13/2015 | |
| Choice of plastic or metal stent for patients with jaundice with pancreaticobiliary malignancy using simple clinical tools a prospective evaluation | CONCLUSIONS: The decision whether to place a plastic stent or SEMS for patients with distal malignant obstructive jaundice may be based on simple clinical tools resulting in low rates of reintervention. | 10/14/2015 | |
| Chronic hepatitis E A brief review | Hepatitis E viral infection has traditionally been considered an acute, self-limited, water borne disease similar to hepatitis A, endemic to developing countries. However, over the past decade, zoonotic transmission and progression to chronicity in human patients has been identified, resulting in pe... | 9/18/2015 | |
| Efficacy of nonsurgical tigecycline pleurodesis for the management of hepatic hydrothorax in patients with liver cirrhosis | Chemical pleurodesis is one of the therapeutic tools to control hepatic hydrothorax. Tetracycline and derivatives have been widely accepted as an effective and safe treatment for the purpose, but availability is the big concern. Tigecycline is an antibiotic derivative of tetracycline, which has demo... | 9/15/2015 | |
| Loperamide Versus Psyllium Fiber for Treatment of Fecal Incontinence The Fecal Incontinence Prescription Rx Management FIRM Randomized Clinical Trial | CONCLUSIONS: Both loperamide and psyllium improve fecal incontinence. Loperamide was associated with more adverse effects, especially constipation. | 9/9/2015 | |
| Incidentally Identified Common Bile Duct Dilatation A Systematic Review of Evaluation, Causes, and Outcome | CONCLUSIONS: Incidentally found biliary tract dilatation can be a manifestation of significant biliary tract disease including malignancy. Long-term outcome is not well defined and further prospective studies examining the most cost-effective approach to evaluation are needed. | 8/25/2015 | |
| What is the current role of endoscopy in primary sclerosing cholangitis | Endoscopy has important roles in the management of primary sclerosing cholangitis (PSC), ranging from narrowing down the differential diagnoses, screening for complications, determining prognosis and therapy. While the need for a diagnostic endoscopic retrograde cholangiopancreatography (ERCP) may b... | 8/13/2015 | |
| Emerging Role of Endoscopic Ultrasound in the Diagnostic Evaluation of Idiopathic Pancreatitis | CONCLUSIONS: Given the high incidence of microlithiasis and/or biliary sludge as a cause of idiopathic pancreatitis as well as the safety and high accuracy, EUS should be considered 1st for evaluation of idiopathic pancreatitis if conventional cross-sectional radiography fails to reveal a cause. | 8/8/2015 | |
| Biliary drainage role of EUS guidance | CONCLUSIONS: In a tertiary-care center, use of advanced ERCP techniques results in a high technical success rate. EUS-guided biliary drainage was required in only 0.6% of native papilla ERCPs, and although a number of excellent indications exist, it should not replace good ERCP technique. | 7/29/2015 | |
| Blocking of targeted microRNAs from next-generation sequencing libraries | Highly abundant microRNAs (miRNAs) in small RNA sequencing libraries make it difficult to obtain efficient measurements of more lowly expressed species. We present a new method that allows for the selective blocking of specific, abundant miRNAs during preparation of sequencing libraries. This techni... | 7/26/2015 | |
| Incidence and predictors of post-ERCP pancreatitis in patients with suspected sphincter of Oddi dysfunction undergoing biliary or dual sphincterotomy results from the EPISOD prospective multicenter randomized sham-controlled study | CONCLUSION: The performance of biliary or dual sphincterotomy does not increase the risk of PEP in patients suspected of SOD. However, the high rate of PEP in patients with suspected SOD, despite pancreatic stenting in expert centers, is confirmed in this prospective study. The combined effect of du... | 7/14/2015 | |
| Subhepatic Sterile Abscess 10 Years After Laparoscopic Cholecystectomy | We present a case of a large, sterile, subhepatic abdominal wall abscess secondary to foreign body reaction to dropped gallstones during laparoscopic cholecystectomy performed 10 years ago. Dropped gallstones are common complications of laparoscopic cholecystectomy, but they rarely result in abscess... | 7/10/2015 | |
| Endoscopic extra-cavitary drainage of pancreatic necrosis with fully covered self-expanding metal stents fcSEMS and staged lavage with a high-flow water jet system | CONCLUSION: ED of complex WON with fcSEMS followed by repeated endoscopic extra-cavitary lavage and debridement using a biliary catheter and high-flow water jet system is a minimally invasive, feasible method with high technical and clinical success and minimal complications. | 7/3/2015 | |
| Percutaneous endoscopic gastrostomy in amyotrophic lateral sclerosis | CONCLUSIONS: In conclusion, PEG tube placement in patients with ALS seems to be a safe procedure in patients without significant respiratory compromise. In patients with FVC <50%, based on literature review and the results of this study, the authors recommend percutaneous radiologic gastrostomy over... | 7/3/2015 | |
| Impact of balloon-assisted enteroscopy on the diagnosis and management of suspected and established small-bowel Crohns disease | CONCLUSIONS: The use of BAE may help improve management in patients with suspected and established small-bowel CD. | 7/3/2015 | |
| Over-the-scope clip placement is effective rescue therapy for severe acute upper gastrointestinal bleeding | CONCLUSIONS: OTSC use represents an effective, easily performed, and safe endoscopic therapy for various causes of severe acute gastrointestinal bleeding when conventional endoscopic techniques have failed. This therapy should be added to the armamentarium of therapeutic endoscopists. | 7/3/2015 | |
| Digestive Disease Week DDW 2015 Pancreaticobiliary update | This update critiques the key abstracts relevant to endoscopic evaluation or interventions in pancreatic and biliary diseases that were presented at Digestive Disease Week (DDW) 2015. We selected 20 abstracts based on their clinical significance, relevance to endoscopic practice and impact on patien... | 6/17/2015 | |
| Single-operator cholangioscopy and targeted biopsies in the diagnosis of indeterminate biliary strictures a systematic review | CONCLUSIONS: Our study suggests that SpyGlass cholangioscopy with SpyBite biopsies has moderate sensitivity for the diagnosis of malignant biliary strictures. | 6/14/2015 | |
| Hepatocellular carcinoma From diagnosis to treatment | Hepatocellular carcinoma (HCC) is the sixth most prevalent malignancy worldwide and is a rising cause of cancer related mortality. Risk factors for HCC are well documented and effective surveillance and early diagnosis allow for curative therapies. The majority of HCC appears to be caused by cirrhos... | 6/9/2015 | |
| Adenoma detection rate in high-risk patients differs from that in average-risk patients | CONCLUSIONS: Patients with a PHP have a significantly higher ADR compared with AR patients. Defining a minimum target ADR for individuals with a PHP undergoing surveillance colonoscopy is important. | 5/31/2015 | |
| Sphincter of Oddi dysfunction Type III New studies suggest new approaches are needed | Sphincter of Oddi dysfunction (SOD) has been classified into three types based upon the presence or absence of objective findings including liver test abnormalities and bile duct dilatation. Type III is the most controversial and is classified as biliary type pain in the absence of any these objecti... | 5/29/2015 | |
| Development and evaluation of a 3D printed endoscopic ampullectomy training model with video | CONCLUSION: Although further studies are necessary for validation, this novel prototype appears useful for endoscopic ampullectomy training. | 5/20/2015 | |
| Approach to patients with esophageal Dysphagia | Patients frequently present to a physician with complaints of difficulty swallowing. The approach to systematically evaluating these problems can be challenging for those who do not manage this type of patient regularly. The potential for life-threatening malignancies is present and makes this evalu... | 5/13/2015 | |
| Non-surgical porto-mesenteric vein thrombosis is associated with worse long-term outcomes in inflammatory bowel diseases | CONCLUSIONS: IBD patients who were inpatients or receiving corticosteroid therapy had an increased risk of the development of PMVT. The presence of PMVT was associated with poor clinical outcomes in IBD. | 4/30/2015 | |
| Diagnosis and management of primary sclerosing cholangitis-perspectives from a therapeutic endoscopist | Primary sclerosing cholangitis (PSC) is a chronic, cholestatic liver condition characterized by inflammation, fibrosis, and destruction of the intra- and extrahepatic bile ducts. The therapeutic endoscopist plays a key role in the diagnosis and management of PSC. In patients presenting with a choles... | 4/28/2015 | |
| Biomarkers in bile-complementing advanced endoscopic imaging in the diagnosis of indeterminate biliary strictures | Biliary strictures present a diagnostic challenge and a conundrum, particularly when an initial work up including abdominal imaging and endoscopic retrograde cholangiopancreatography based sampling are non-diagnostic. Advances in endoscopic imaging have helped us diagnose these strictures better. Ho... | 4/23/2015 | |
| H and D attachment to naphthalene spectra and thermochemistry of cold gas-phase 1-C10H9 and 1-C10H8D radicals and cations | Excitation spectra of the 1H-naphthalene (1-C10H9) and 1D-naphthalene (1-C10H8D) radicals, and their cations, are obtained by laser spectroscopy and mass spectrometry of a skimmed free-jet expansion following an electrical discharge. The spectra are assigned on the basis of density functional theory... | 3/11/2015 | |
| Primary sclerosing cholangitis and the risk of colon neoplasia in patients with Crohns colitis | CONCLUSIONS: CC patients with PSC appear not to be at increased risk of developing colon neoplasia. Among patients in our cohort with colon neoplasia and concurrent PSC, the neoplasia occurred in the proximal colon in all cases. | 3/1/2015 | |
| An immunosuppressed man with an aortic rupture secondary to Salmonella aortitis successfully treated with endovascular aortic repair | A 75-year-old immunosuppressed man presented with fever and central abdominal pain 3 weeks after having positive blood cultures for Salmonella enteritidis. A computed tomography scan demonstrated a contained perforation of a nonaneurysmal abdominal aorta. Salmonella aortitis was suspected, and given... | 2/28/2015 | |
| Volatile Organic Compounds in Urine for Noninvasive Diagnosis of Malignant Biliary Strictures A Pilot Study | CONCLUSIONS: Measurement of VOCs in urine may diagnose malignant biliary strictures noninvasively. | 2/25/2015 | |
| Utility of Platelet Count for Predicting Cirrhosis in Alcoholic Liver Disease Model for Identifying Cirrhosis in a US Population | CONCLUSIONS: A simple model of platelet count and INR has good diagnostic accuracy for identifying cirrhosis in alcoholics. | 2/22/2015 | |
| Evaluation of Patients Knowledge Regarding Smoking and Chronic Pancreatitis A Pilot Study | CONCLUSION: Elaborate studies involving greater number of study population, are necessary to better define measuring tools and to further assess patient's knowledge regarding the relationship between smoking and chronic pancreatitis. Additionally, efforts should be directed towards enhancing physici... | 2/17/2015 | |
| Effect of quality of bowel preparation on quality indicators of adenoma detection rates and colonoscopy completion rates | CONCLUSIONS: Patients with fair and poor standards of preparation have significantly lower colonoscopy completion rates than those with excellent and good preparation. However, there was no difference in ADR between the different grades of preparation. | 2/15/2015 | |
| ERCP-related perforations in the new millennium A large tertiary referral center 10-year experience | CONCLUSIONS: In our study, leaks were much more common than perforations and the majority of patients were successfully managed with conservative therapy alone. We report a very low perforation rate and most perforations can be managed conservatively with a good outcome. | 2/6/2015 | |
| Poor agreement between endoscopists and gastrointestinal pathologists for the interpretation of probe-based confocal laser endomicroscopy findings | CONCLUSION: There is a wide discrepancy in the interpretation of pCLE findings between endoscopists and pathologist, particularly for benign and malignant pancreaticobiliary lesions. Further studies are needed to identify the cause of this poor agreement. | 12/31/2014 | |
| Impact of transjugular intrahepatic portosystemic shunt on post-colectomy complications in patients with ulcerative colitis and primary sclerosing cholangitis | CONCLUSION: Patients with PSC and UC who underwent TIPS prior to colectomy had higher rates of complications; however, this was probably due to the greater severity of cirrhosis and PSC in this population. | 12/19/2014 | |
| Efficacy of metal and plastic stents for transmural drainage of pancreatic fluid collections a systematic review | CONCLUSIONS: Current evidence does not support routine placement of metal stents for transmural drainage of PFC. Randomized trials are needed to justify the use of metal stents for PFC drainage. | 12/18/2014 | |
| IgG4 Levels in Bile for Distinguishing IgG4-Associated Cholangiopathy from Other Biliary Disorders A Single Blinded Pilot Study | CONCLUSIONS: The results of this pilot study suggest that measurement of biliary IgG4 levels may have clinical value in distinguishing patients with IAC from biliary disorders that can mimic IAC. | 12/16/2014 | |
| Volatile organic compounds in bile for early diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis a pilot study | CONCLUSION: The measurement of VOCs in biliary fluid may be useful to diagnose CCA in patients with PSC. A larger study with a longitudinal study design is required to confirm our pilot observations to diagnose CCA early in patients with PSC. ( | 12/16/2014 | |
| Comparative effectiveness of biliary brush cytology and intraductal biopsy for detection of malignant biliary strictures a systematic review and meta-analysis | CONCLUSION: Our study suggests that both brushings and biopsy are comparable and have limited sensitivity for the diagnosis of malignant biliary strictures. A combination of both only modestly increases the sensitivity. | 12/3/2014 | |
| Precut sphincterotomy efficacy for ductal access and the risk of adverse events | CONCLUSIONS: Precut sphincterotomy is effective in achieving ductal access when standard cannulation techniques fail. A successful precut sphincterotomy is not associated with an increased risk of adverse events. | 12/3/2014 | |
| Chronic pancreatitis pain pattern and severity are independent of abdominal imaging findings | CONCLUSIONS: Mechanisms that determine patterns and severity of pain in patients with chronic pancreatitis are largely independent of structural variants observed by abdominal imaging techniques. Pancreas-relevant quantitative and qualitative pain measures should be included in the evaluation of pat... | 11/27/2014 | |
| Comparison of outcomes for patients with primary sclerosing cholangitis associated with ulcerative colitis and Crohns disease | CONCLUSIONS: PSC patients with CD appear to be associated with a lower risk of colon neoplasia and colectomy than PSC patients with UC. | 10/31/2014 | |
| Comparative effectiveness of pyruvate kinase M2 in bile, serum carbohydrate antigen 19-9, and biliary brushings in diagnosing malignant biliary strictures | CONCLUSIONS: As a stand-alone factor, none of the markers were able to distinguish benign from malignant biliary strictures with a high sensitivity. However, a combination was highly sensitive in diagnosing malignant biliary strictures. | 10/26/2014 | |
| Outcomes after implementing a tailored endoscopic step-up approach to walled-off necrosis in acute pancreatitis | CONCLUSION: An algorithmic approach to pancreatic and peripancreatic walled-off necrosis, based on the collection size, location and stepwise response to intervention, resulted in an improved rate of treatment success compared with conventional endoscopic management. | 10/22/2014 | |
| Endoscopic ultrasound-guided management of pancreatic pseudocysts and walled-off necrosis | The outcome of endoscopic management of pancreatic fluid collections is dependent on the type of collection being treated. While pseudocysts have an excellent treatment response, the outcomes are modest for walled-off pancreatic necrosis. Recent advances in cross-sectional body imaging have enabled ... | 10/18/2014 | |
| Neoplasia in chronic pancreatitis how to maximize the yield of endoscopic ultrasound-guided fine needle aspiration | When performing endoscopic ultrasound-guided fine needle aspiration (EUS-FNA), identifying neoplasia in the setting of chronic pancreatitis can be technically challenging. The morphology of an ill-defined mass on sonography, presence of calcifications or intervening collaterals, reverberation from a... | 10/18/2014 | |
| Bile proteomics for differentiation of malignant from benign biliary strictures a pilot study | CONCLUSIONS: Protein biomarkers in bile may differentiate malignant from benign biliary strictures. Larger studies are warranted to validate these observations. | 10/12/2014 | |
| Utility of double-balloon enteroscopy in patients with left ventricular assist devices and obscure overt gastrointestinal bleeding | Obscure overt gastrointestinal bleeding (OGIB) is a challenge in patients with left ventricular assist devices (LVADs). We evaluated the utility and safety of double-balloon enteroscopy (DBE) in patients with LVADs in an observational consecutive-patient cohort from a single tertiary referral center... | 10/8/2014 | |
| Human gastric epithelial cells contribute to gastric immune regulation by providing retinoic acid to dendritic cells | Despite the high prevalence of chronic gastritis caused by Helicobacter pylori, the gastric mucosa has received little investigative attention as a unique immune environment. Here, we analyzed whether retinoic acid (RA), an important homeostatic factor in the small intestinal mucosa, also contribute... | 9/25/2014 | |
| Randomized Trial Comparing the Flexible 19G and 25G Needles for Endoscopic Ultrasound-Guided Fine Needle Aspiration of Solid Pancreatic Mass Lesions | CONCLUSIONS: As there is no significant difference in the performance of flexible 19G and 25G needles, needle choice for sampling pancreatic masses should be based on endoscopist preference and need for histology. | 9/19/2014 | |
| New method of direct percutaneous endoscopic jejunostomy tube placement using balloon-assisted enteroscopy with fluoroscopy | CONCLUSIONS: This new method of inserting a DPEJ using balloon enteroscopy and fluoroscopy was safe and successful. Future comparative studies are now warranted. | 9/12/2014 | |
| Endoscopic ultrasound in the diagnosis of cholangiocarcinoma as the etiology of biliary strictures a systematic review and meta-analysis | CONCLUSIONS: Our study suggests that EUS-FNA is useful in the evaluation of CCA as the etiology of biliary strictures. EUS-FNA may improve the diagnosis of CCA in patients with negative cytology and no mass on cross-sectional imaging. | 8/30/2014 | |
| Training endosonographers in cytopathology improving the results of EUS-guided FNA | CONCLUSIONS: An intensive 2-day program was effective in training endosonographers in the basics of EUS-related cytopathology. Incorporating basic cytopathology in EUS fellowship curriculum will likely improve diagnostic performance of tissue acquisition procedures. | 8/16/2014 | |
| Role of strain imaging in right heart disease a comprehensive review | Advances in the imaging techniques of the heart have fueled the interest in understanding of right heart pathology. Recently, speckle tracking echocardiography has shown to aid in understanding various right heart diseases and better management. Its role is well established in diagnosing right heart... | 8/12/2014 | |
| Safety and yield of diagnostic ERCP in liver transplant patients with abnormal liver function tests | Background. Abnormal liver enzymes postorthotopic liver transplant (OLT) may indicate significant biliary pathology or organ rejection. There is very little known in the literature regarding the current role of diagnostic ERCP in this scenario. Aim. To review the utility of diagnostic ERCP in patien... | 8/12/2014 | |
| ERCP-related adverse events in patients with primary sclerosing cholangitis | CONCLUSION: Cholangitis appears to be the most common adverse event despite intraprocedural antibiotic use. There was a low risk of adverse events in patients with PSC undergoing ERCP. | 8/3/2014 | |
| Timing of esophageal stent placement and outcomes in patients with esophageal perforation a single-center experience | CONCLUSIONS: Endoscopic stent placement is safe and effective for treating esophageal perforations. However, the timing of stent placement on outcomes remains unclear. | 7/19/2014 | |
| The 25-gauge EUS-FNA needle Good for on-site but poor for off-site evaluation Results of a randomized trial | CONCLUSIONS: The 25-gauge FNA needle yielded a diagnostic cell block in only 81% of patients, irrespective of whether 2 or 4 FNA passes were performed. These findings have important implications for centers without on-site cytopathology services. (Clinical trial registration number NCT01809028.). | 6/29/2014 | |
| Hepatobiliary manifestations of ulcerative colitis an example of gut-liver crosstalk | The interaction between inflammatory bowel disease (IBD) and hepatobiliary manifestations represents a classic example of liver-gut crosstalk. The importance of liver-gut crosstalk in IBD is demonstrated in the pathogenesis and outcome of primary sclerosing cholangitis (PSC) in IBD patients. Immunog... | 6/22/2014 | |
| Volatile organic compounds in bile can diagnose malignant biliary strictures in the setting of pancreatic cancer a preliminary observation | CONCLUSIONS: The measurement of biliary fluid VOCs may help to distinguish malignant from benign biliary strictures. Further studies are warranted to validate these observations. (Clinical Trial Registration Number NCT01565460.). | 6/16/2014 | |
| Risk of comorbidities and outcomes in patients with lower gastrointestinal bleeding - a nationwide study | CONCLUSIONS: Comorbidities were associated with increased the risk of mortality and health care utilization in patients with LGIB. Identification of comorbidities and development of risk-adjustment tools may improve the outcome of patients with LGIB. | 6/11/2014 | |
| Administration of secretin RG1068 increases the sensitivity of detection of duct abnormalities by magnetic resonance cholangiopancreatography in patients with pancreatitis | CONCLUSIONS: Compared with images from MRCP, those from RG1068-stimulated MRCP are improved in many aspects and could aid in diagnosis and clinical decision making for patients with acute, acute recurrent, or chronic pancreatitis. RG1068-enhanced MRCP might also better identify patients in need of t... | 6/7/2014 | |
| Prevalence of normal liver tests in patients with choledocholithiasis undergoing endoscopic retrograde cholangiopancreatography | CONCLUSIONS: Although rare, liver tests can be normal in patients with CBD stones. Patients most likely to have normal liver tests included older patients and those with abdominal pain. | 6/7/2014 | |
| Early precut sphincterotomy and the risk of endoscopic retrograde cholangiopancreatography related complications An updated meta-analysis | CONCLUSION: This meta-analysis suggests that pre-cut sphincterotomy and persistent attempts at cannulation are comparable in terms of overall complication rates. Early pre-cut implementation does not increase PEP complications. | 6/4/2014 | |
| ERCP with the overtube-assisted enteroscopy technique a systematic review | CONCLUSION: Both endoscopic and ERCP success rates were highest in patients with Billroth II anatomy, followed by those with pancreaticoduodenectomy and Roux-en-Y hepaticojejunostomy; the lowest success rates were in patients with Roux-en-Y gastric bypass. Cannulation rates appeared to be equivalent... | 5/20/2014 | |
| Relationship between stent characteristics and treatment outcomes in endoscopic transmural drainage of uncomplicated pancreatic pseudocysts | CONCLUSIONS: There appears to be no relationship between the number of interventions required for treatment success and stent characteristics in patients undergoing endoscopic transmural drainage of uncomplicated pancreatic pseudocysts. | 5/3/2014 | |
| Lipidomic profiling of bile in distinguishing benign from malignant biliary strictures a single-blinded pilot study | CONCLUSIONS: The measurement of specific oxPL products may help to distinguish CCA from other biliary strictures. Measurement of these products in bile may enhance the endoscopic diagnosis of indeterminate biliary strictures. | 4/9/2014 | |
| Advanced therapeutic endoscopist and inflammatory bowel disease dawn of a new role | Endoscopy plays a key role in the diagnosis and treatment of patients with inflammatory bowel disease (IBD). Colonoscopy has been traditionally used in the diagnosis of IBD and helps in determination of an important end point in patient management, "mucosal healing". However, the involvement of an a... | 4/8/2014 | |
| Endoscopic resection of large sporadic non-ampullary duodenal polyps efficacy and long-term recurrence | CONCLUSIONS: Endoscopic resection is effective for treating large duodenal adenomas. Adenomas with villous features are more likely to recur. Almost all recurrences can be managed endoscopically. | 4/4/2014 | |
| Factors predicting adverse short-term outcomes in patients with acute cholangitis undergoing ERCP A single center experience | CONCLUSION: Higher ASA physical classification and delays in ERCP are associated with adverse clinical outcomes and prolonged length of hospital stay in patients with acute cholangitis undergoing ERCP. | 3/18/2014 | |
| Pancreatico-pericardial fistula as a complication of chronic pancreatitis | Pancreatico-pericardial fistula is an extremely rare complication of chronic pancreatitis. We present a case of a 58-year-old man who presented with syncope. Transthoracic echocardiogram revealed a pericardial effusion with tamponade physiology. Pericardiocentesis and pericardial fluid analysis demo... | 3/15/2014 | |
| Impact of pancreatic stent caliber on post-endoscopic retrograde cholangiopancreatogram pancreatitis rates in patients with confirmed sphincter of Oddi dysfunction | CONCLUSIONS: There appears to be no relationship between stent characteristics and the risk or severity of PEP in patients with manometrically proven SOD. | 3/13/2014 | |
| Small Bowel Stent-in-Stent Placement for Malignant Small Bowel Obstruction Using a Balloon-Assisted Overtube Technique | Self-expanding metal stents are a useful therapy to palliate malignant and benign luminal gastrointestinal obstruction. Self-expanding metal stents has been widely reported for colonic, esophageal, and gastric obstruction. However, endoscopic delivery and placement to the small bowel is more challen... | 2/27/2014 | |
| Utility of confocal laser endomicroscopy in identifying high-grade dysplasia and adenocarcinoma in Barretts esophagus a systematic review and meta-analysis | Confocal laser endomicroscopy (CLE) is a novel endoscopic technique that has emerged as an important tool in the in-vivo visualization and detailed assessment of the mucosal layer and subcellular structures in Barrett's esophagus. Current guidelines recommend four-quadrant random biopsies for identi... | 2/19/2014 | |
| Endoscopic treatment options for cholangiocarcinomas | Cholangiocellular carcinoma (CCC) is a very aggressive tumor, which remains highly resistant to current chemoradiation therapies. Death is usually caused by the tumor burden. However, biliary obstruction, which leads to cholangitis and liver failure, is also a cause of death. Therefore, relief of bi... | 2/11/2014 | |
| Can patient and pain characteristics predict manometric sphincter of Oddi dysfunction in patients with clinically suspected sphincter of Oddi dysfunction | CONCLUSIONS: Patient and pain factors and psychological comorbidity do not predict SOM results at ERCP in suspected type III SOD. ( | 1/30/2014 | |
| Aspirin and proton pump inhibitor combination therapy for prevention of cardiovascular disease and Barretts esophagus | Aspirin, used at low doses (75-325 mg daily), prevents aggregation of platelets and is prescribed for patients as pharmacologic prevention of cardiovascular disease. Despite the well-documented beneficial effects of aspirin, prolonged use is associated with damage to the gastrointestinal (GI) mucosa... | 1/8/2014 | |
| Present and future perspectives of virtual chromoendoscopy with i-scan and optical enhancement technology | Despite being the current gold standard, white-light endoscopy may miss a significant proportion of lesions within the colorectum, thus leading to a misinterpretation of various disease findings. Traditionally, dye-based chromoendoscopy is used to improve both detection and characterization of lesio... | 12/31/2013 | |
| Fluorescence in situ hybridization for diagnosis of cholangiocarcinoma in primary sclerosing cholangitis a systematic review and meta-analysis | CONCLUSION: Our study suggests that FISH polysomy is highly specific; however, limited sensitivity of FISH highlights that better markers are required for early detection of CCA in PSC. | 12/24/2013 | |
| Factors associated with 30-day readmission and long-term efficacy of enteral stent placement for malignancy | CONCLUSIONS: Early complications following stent placement increase the risk of 30-day readmission. SEMS is efficacious long-term for palliation of malignant gastrointestinal obstruction. | 11/16/2013 | |
| The changing paradigm in EUS-guided tissue acquisition | The diagnostic performance of endoscopic ultrasound-guided fine-needle aspiration is strongly dependent on the availability of an onsite cytopathologist. The diagnosis of some rare tumors may require ancillary testing for which a histologic core biopsy is required. There is increasing interest in ev... | 11/13/2013 | |
| Enteroscopy in small bowel Crohns disease A review | Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract resulting in inflammation, stricturing and fistulae secondary to transmural inflammation. Diagnosis relies on clinical history, abnormal laboratory parameters, characteristic radiologic and endoscopic changes with... | 10/23/2013 | |
| Procore and flexible 19 gauge needle can replace trucut biopsy needle | Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is routinely performed for establishing tissue diagnosis in patients with gastrointestinal tumors. The concept of delivering chemotherapy based on molecular markers and the ability to establish a reliable diagnosis in lieu of an onsite cy... | 10/22/2013 | |
| Metal versus Plastic Stent for Transmural Drainage of Pancreatic Fluid Collections | The conventional management of pancreatic fluid collections (PFCs) involves surgery or percutaneous drainage. While surgery is associated with significant complications and mortality, percutaneous drainage is associated with prolonged hospitalization and oftentimes the need for other adjunctive trea... | 10/22/2013 | |
| Diagnostic yield of bile duct brushings for cholangiocarcinoma in primary sclerosing cholangitis a systematic review and meta-analysis | CONCLUSION: Our study suggests that bile duct brushing is a simple and highly specific technique for detection of CCA in patients with PSC. However, the modest sensitivity from bile duct brushing precludes its utility as a diagnostic tool for early detection of CCA in patients with PSC. | 10/22/2013 | |
| Increased mortality with peptic ulcer bleeding in patients with both compensated and decompensated cirrhosis | CONCLUSION: Both decompensated and compensated cirrhosis are associated with increased mortality in patients with PUB. | 10/15/2013 | |
| Hepatocellular carcinoma options for diagnosing and managing a deadly disease | Hepatocellular carcinoma (HCC) is an important cause of death in patients with liver disease, and its incidence appears to be rising in the United States. Because early diagnosis improves the chances of survival, it is important to identify patients who would benefit from surveillance. Once HCC is s... | 10/3/2013 | |
| Timing of colonoscopy and outcomes in patients with lower GI bleeding a nationwide population-based study | CONCLUSIONS: Early colonoscopy within 24 hours is associated with decreased length of hospital stay and hospitalization costs in patients with LGIB. | 9/25/2013 | |
| Endoscopic ultrasound-guided tissue acquisition | Endoscopic ultrasound (EUS) is an indispensable tool for tissue acquisition in patients with gastrointestinal tumors. While fine-needle aspiration (FNA) has been routinely carried out for establishing tissue diagnosis, the emerging concept of tailoring chemotherapeutic agents based on molecular mark... | 9/17/2013 | |
| Endoscopic closure of a gastrocolic fistula using the over-the-scope-clip-system | Gastrointestinal (GI) defects such as fistulas and leaks can be potentially closed endoscopically using hemoclips and loops. However, hemoclips may not allow for closure of large defects and they do not exert enough tensile force to keep fibrotic defects larger than 5 mm approximated. Herein we pres... | 8/17/2013 | |
| Progression of low-grade dysplasia to advanced neoplasia based on the location and morphology of dysplasia in ulcerative colitis patients with extensive colitis under colonoscopic surveillance | CONCLUSIONS: The frequency of progression of LGD to AN is low. Flat dysplasia located in the distal colon is associated with a greater risk of progression to AN. | 8/7/2013 | |
| Microscopic colitis is it a spectrum of inflammatory bowel disease | Lymphocytic and collagenous colitis are forms of microscopic colitis which typically presents in elderly patients as chronic watery diarrhea. The association between microscopic colitis and inflammatory bowel disease is weak and unclear. Lymphocytic colitis progressing to ulcerative colitis has been... | 7/19/2013 | |
| Multipurpose use of the bear claw over-the-scope-clip system to treat endoluminal gastrointestinal disorders | CONCLUSIONS: The OTSC system is a useful device in a variety of clinical scenarios including the management of larger GI leaks and fistulas, GI bleeding, full-thickness resection of tumors, and stent anchoring, even in very old and frail patients. | 7/17/2013 | |
| Factors impacting treatment outcomes in the endoscopic management of walled-off pancreatic necrosis | CONCLUSIONS: Creating multiple gateways for drainage of necrotic debris improves treatment success, and not removing the transmural stents decreases PFC recurrence in patients undergoing endoscopic drainage of WOPN. | 7/9/2013 | |
| Vascular endothelial growth factor levels in bile distinguishes pancreatic cancer from other etiologies of biliary stricture a pilot study | CONCLUSIONS: This study suggests that measurement of biliary VEGF-1 levels distinguishes patients with pancreatic cancer from other etiologies of biliary stricture. This may be particularly relevant in approaching patients with indeterminate biliary stricture. | 7/6/2013 | |
| Novel challenges of multi-society investigator-initiated studies a paradigm shift for technique and technology evaluation | The introduction of innovative techniques and novel technologies into clinical practice is a challenge that confronts all aspects of healthcare delivery. Upheaval from shrinking research funding and declining healthcare reimbursements now forces patients, doctors, hospitals, payers, regulators, and ... | 6/12/2013 | |
| Equal efficacy of endoscopic and surgical cystogastrostomy for pancreatic pseudocyst drainage in a randomized trial | CONCLUSIONS: In a randomized trial comparing endoscopic and surgical cystogastrostomy for pancreatic pseudocyst drainage, none of the patients in the endoscopy group had pseudocyst recurrence during the follow-up period, therefore there is no evidence that surgical cystogastrostomy is superior. Howe... | 6/5/2013 | |
| Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells | Increased apoptotic death of gastric epithelial cells is a hallmark of Helicobacter pylori infection, and altered epithelial cell turnover is an important contributor to gastric carcinogenesis. To address the fate of apoptotic gastric epithelial cells and their role in H. pylori mucosal disease, we ... | 5/21/2013 | |
| De novo inflammatory bowel disease and its mimics after organ transplantation | Diarrhea is a common symptom after solid organ transplantation or hematopoietic stem cell transplantation, with a reported prevalence up to 72%. One of the uncommon causes for diarrhea in the posttransplant setting is development of de novo inflammatory bowel disease (IBD). The incidence of posttran... | 5/10/2013 | |
| Delay in performing ERCP and adverse events increase the 30-day readmission risk in patients with acute cholangitis | CONCLUSION: Delays in performing ERCP during the index admission, development of after-ERCP adverse events, and etiology of cholangitis not related to stones increased the risk of 30-day readmissions. | 3/27/2013 | |
| Random biopsies during surveillance colonoscopy increase dysplasia detection in patients with primary sclerosing cholangitis and ulcerative colitis | CONCLUSIONS: Random biopsies significantly increase the yield of dysplasia in patients with PSC and UC even in the absence of endoscopic features of prior inflammation and significantly impact clinical outcomes. | 3/26/2013 | |
| Biliary sphincterotomy is not required for bile duct stent placement | CONCLUSION: Single bile duct stents, both plastic and metal, can be deployed without EBS. | 3/23/2013 | |
| Randomized trial comparing fanning with standard technique for endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic mass lesions | CONCLUSIONS: The fanning technique of FNA was superior to the standard approach because fewer passes were required to establish the diagnosis. If these promising data are confirmed by other investigators, consideration should be given to incorporating the fanning technique into routine practice of E... | 3/19/2013 | |
| Endomicroscopy of the pancreaticobiliary system | It is often difficult to accurately differentiate between benign and malignant pancreaticobiliary strictures, and some are interpreted as indeterminate despite ERCP, EUS, or radiological imaging techniques, thereby making it difficult for the clinician to make appropriate management decisions. Probe... | 3/12/2013 | |
| Natural history of low grade dysplasia in patients with primary sclerosing cholangitis and ulcerative colitis | CONCLUSIONS: One-third of patients with LGD progressed to HGD/CRC in PSC-UC. Most patients progress within the first year of diagnosis of LGD supporting early colectomy in PSC-UC patients with LGD. | 2/26/2013 | |
| Backwash ileitis and the risk of colon neoplasia in ulcerative colitis patients undergoing restorative proctocolectomy | CONCLUSIONS: The presence of BWI with extensive colitis was associated with the risk of identifying colon neoplasia but not cancer alone in the proctocolectomy specimen. | 2/2/2013 | |
| Objective assessment of an algorithmic approach to EUS-guided FNA and interventions | CONCLUSION: An algorithmic approach to EUS-FNA/interventions yielded better technical outcomes and cost savings without compromising diagnostic adequacy. | 2/2/2013 | |
| Physical and mental quality of life in chronic pancreatitis a case-control study from the North American Pancreatitis Study 2 cohort | CONCLUSIONS: The impact of CP on QOL appears substantial. The QOL in CP subjects appears to be worse or similar to the QOL of many other chronic conditions. | 1/30/2013 | |
| End-stage renal disease is associated with worse outcomes in hospitalized patients with peptic ulcer bleeding | CONCLUSIONS: ESRD is associated with a significant health care burden in hospitalized patients with PUB. The presence of ESRD contributes to a higher mortality rate, longer hospital stay, and increased need for surgery. | 1/30/2013 | |
| Endoscopic management of difficult common bile duct stones | Endoscopy is widely accepted as the first treatment option in the management of bile duct stones. In this review we focus on the alternative endoscopic modalities for the management of difficult common bile duct stones. Most biliary stones can be removed with an extraction balloon, extraction basket... | 1/25/2013 | |
| Use of anesthesia on the rise in gastrointestinal endoscopy | Conscious sedation has been the standard of care for many years for gastrointestinal endoscopic procedures. As procedures have become more complex and lengthy, additional medications became essential for adequate sedation. Often time's deep sedation is required for procedures such as endoscopic retr... | 1/19/2013 | |
| Endoscopic ultrasound fine needle aspiration Technique and applications in clinical practice | Since its initial report in 1992, endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) has now been incorporated into the diagnostic and staging algorithm for the evaluation of benign and malignant diseases of the gastrointestinal tract and of adjacent organs. Its introduction constitutes a... | 1/8/2013 | |
| Diagnostic and therapeutic yield is not influenced by the timing of small-bowel enteroscopy morning versus afternoon | CONCLUSIONS: The timing of procedure, morning versus afternoon, did not affect the diagnostic and therapeutic efficacy of BE in patients with suspected small-bowel disease. | 12/25/2012 | |
| Comparison of outcomes between endoscopic ultrasound-guided transcolonic and transrectal drainage of abdominopelvic abscesses | CONCLUSION: Except for patients with diverticular etiology, treatment of abdominopelvic abscess under EUS guidance is highly effective and safe for both routes. | 12/11/2012 | |
| Diagnosis and therapeutic management of extra-intestinal manifestations of inflammatory bowel disease | Extra-intestinal manifestations (EIMs) are reported frequently in patients with inflammatory bowel disease (IBD) and may be diagnosed before, concurrently or after the diagnosis of IBD. EIMs in IBD may be classified based on their association with IBD disease activity. The first group has a direct r... | 11/28/2012 | |
| Diagnosis and management of Barretts esophagus | Barrett esophagus is characterized by the replacement of squamous mucosa in the esophagus by specialized intestinal metaplasia. Its clinical significance lies in it being the strongest risk factor for and known precursor for esophageal adenocarcinoma. Diagnosis requires endoscopic confirmation of co... | 10/3/2012 | |
| Increased serum levels of carbohydrate antigen 19-9 and outcomes in primary sclerosing cholangitis patients without cholangiocarcinoma | CONCLUSIONS: Thirty-two percent of patients with PSC had elevated serum CA 19-9 in the absence of CCA. There was a trend towards shorter OLT-free survival in PSC patients with elevated CA-19-9. | 9/26/2012 | |
| Impact of inflammatory bowel disease on post-cholecystectomy complications and hospitalization costs a Nationwide Inpatient Sample study | CONCLUSIONS: CD patients undergoing cholecystectomy were shown to have a significantly increased risk for postoperative complications, have a longer stay in the hospital, and incur higher hospitalization costs. | 9/11/2012 | |
| Endoscopic ultrasound-guided fine needle aspiration in cystic pancreatic lesions | Incidental pancreatic cysts are being increasingly recognized recently with incremented concern about health and frequent health check-up. Endoscopic ultrasound (EUS) has emerged as the principal modality for imaging pancreas for various pancreatic diseases including pancreatic cyst. But imaging alo... | 8/7/2012 | |
| Assessment of the technical performance of the flexible 19-gauge EUS-FNA needle | CONCLUSIONS: Preliminary data suggest that the flexible 19-G needle can be used for procuring cytologic aspirates and histologic specimens and to undertake therapeutic interventions even by the transduodenal route. Confirmatory studies are required in a larger cohort of patients with varied patholog... | 7/24/2012 | |
| Risk factors associated with a decrease 2 gdL in haemoglobin andor 10 haematocrit in osteoarthritis patients taking celecoxib or a nonselective NSAID plus a PPI in a large randomised controlled trial CONDOR | CONCLUSIONS: Monitoring for decreases in haemoglobin should be considered for all OA patients and especially those with an increased age, BMI, history of gastritis and GI intolerance, CRP levels >1 mg/dL and/or positive H. pylori status, as this may affect their clinical management. | 7/19/2012 | |
| Impact of ileal pouch-anal anastomosis on the surgical outcome of orthotopic liver transplantation for primary sclerosing cholangitis | CONCLUSIONS: The presence of the IPAA in OLT for PSC patients appears not to have a negative impact on patient and graft survivals and post-operative complications. | 7/14/2012 | |
| Endoscopic ultrasound-guided drainage of pancreatic fluid collections in children | CONCLUSIONS: Single-step EUS-guided drainage of PFC in children is technically feasible, safe, clinically effective, and when available, should be the first-line treatment modality. | 7/13/2012 | |
| Current controversies in fluid resuscitation in acute pancreatitis a systematic review | Acute pancreatitis (AP) is a common inflammatory disorder of the pancreas resulting in considerable morbidity and mortality. Aggressive intravenous fluid resuscitation generally is recommended in all patients with AP and remains the cornerstone of management of these patients. However, the optimal r... | 7/12/2012 | |
| Impact of biliary stents on EUS-guided FNA of pancreatic mass lesions | CONCLUSIONS: The presence or absence of a biliary stent, whether plastic or metal, does not have an impact on the diagnostic yield or technical difficulty of EUS-FNA. | 6/26/2012 | |
| Crohns disease with pulmonary manifestations in children 2 case reports and review of the literature | Crohn's disease (CD) is a chronic granulomatous disease of unknown etiology that affects primarily the gastrointestinal system but can be associated with extraintestinal manifestations. Latent pulmonary involvement in children with CD has been described, but symptomatic pulmonary disease has rarely ... | 6/19/2012 | |
| Randomized trial comparing the 22-gauge aspiration and 22-gauge biopsy needles for EUS-guided sampling of solid pancreatic mass lesions | CONCLUSION: Diagnostic sufficiency, technical performance, and safety profiles of FNA and FNB needles are comparable. There was no significant difference in yield or quality of the histologic core between the 2 needle types. | 6/5/2012 | |
| EUS-guided FNA of solid pancreas tumors | Although endoscopic ultrasonography (EUS) is considered superior to MRI and CT in detecting pancreatic masses, it is the ability to target and place a needle into suspicious lesions that has made EUS indispensible in the evaluation of patients with solid pancreatic tumors. Endoscopic ultrasound-guid... | 5/29/2012 | |
| Antegrade is more effective than retrograde enteroscopy for evaluation and management of suspected small-bowel disease | CONCLUSIONS: Antegrade enteroscopy appears to provide a higher diagnostic and therapeutic yield than retrograde enteroscopy in patients with suspected small-bowel disease. | 5/22/2012 | |
| Elevated immunoglobulin G4 level is associated with reduced colectomy-free survival in patients with primary sclerosing cholangitis and ulcerative colitis | CONCLUSIONS: Elevated IgG4 was seen in a small number of PSC patients. Most of these patients had associated UC, were younger at the time of PSC diagnosis, more likely to have backwash ileitis and had reduced colectomy-free survival than patients with normal IgG4. | 5/5/2012 | |
| Best practices in endoscopic ultrasound-guided fine-needle aspiration | Over the past 2 decades, endoscopic ultrasound-guided fine-needle aspiration has evolved to become an indispensable tool for tissue acquisition in patients with gastrointestinal tumors. The technique is useful for biopsy of mucosal and submucosal lesions in which prior endoscopic biopsies have been ... | 4/6/2012 | |
| Utility of fecal and serum anti-Saccharomyces cerevisiae antibodies in the diagnosis of Crohns disease-like condition of the pouch | CONCLUSIONS: Fecal ASCA appears to be better than serum ASCA in differentiating CDL from other pouch disorders, although this distinction may be of limited clinical utility. | 3/21/2012 | |
| The effects of liver transplantation on the clinical course of colitis in ulcerative colitis patients with primary sclerosing cholangitis | CONCLUSIONS: Ulcerative colitis in the presence of primary sclerosing cholangitis remains quiescent, and may improve in most patients after orthotopic liver transplantation. | 3/21/2012 | |
| The impact of ulcerative colitis on the long-term outcome of patients with primary sclerosing cholangitis | CONCLUSIONS: Primary sclerosing cholangitis often is recognised at an early stage in patients with concurrent ulcerative colitis; ulcerative colitis has no impact on long-term prognosis in terms of liver-related outcomes when adjusted for the severity of liver disease. | 3/21/2012 | |
| Duration and severity of primary sclerosing cholangitis is not associated with risk of neoplastic changes in the colon in patients with ulcerative colitis | CONCLUSION: In this study, the severity of PSC was not significantly associated with the risk of colon neoplasia. Patients with PSC and UC have a high risk of colon neoplasia soon after the coexistence of the two diseases is discovered. Older age at PSC diagnosis increases this risk. | 3/13/2012 | |
| Clostridium difficile infection is associated with worse long term outcome in patients with ulcerative colitis | CONCLUSIONS: CDI appears to be associated with escalation of medical therapy in the year following infection. CDI and severe disease on endoscopy appear to be associated with an increased risk for subsequent colectomy on long-term follow up. | 3/13/2012 | |
| Severity of primary sclerosing cholangitis and its impact on the clinical outcome of Crohns disease | CONCLUSIONS: In contrast to UC, severe PSC requiring OLT does not appear to impact the clinical outcome of CD. | 3/9/2012 | |
| Temporal trends in colon neoplasms in patients with primary sclerosing cholangitis and ulcerative colitis | CONCLUSIONS: With annual colonoscopic surveillance, dysplasia and cancer in patients with a combined diagnosis of PSC//UC is being diagnosed in patients with a shorter duration of these conditions. The nature and the location of neoplasia have, however, not changed. | 3/9/2012 | |
| Severe disease on endoscopy and steroid use increase the risk for bowel perforation during colonoscopy in inflammatory bowel disease patients | CONCLUSIONS: There appears to be a higher risk of colonoscopy-associated perforation in IBD patients with active disease and on steroids. | 3/9/2012 | |
| Modern treatment of patients with chronic pancreatitis | CP remains a challenging disease. Endoscopic and surgical management, along with antioxidants, have helped in reducing chronic pain. Management of exocrine and endocrine insufficiency forms the cornerstone for improving nutrition in these patients. Newer therapeutic targets that will transcend the m... | 2/21/2012 | |
| Isospora belli superinfection in a patient with eosinophilic gastroenteritis--a diagnostic challenge | Isospora belli infection, characterized by peripheral blood eosinophilia, is often seen as an opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS). It is also reported in patients with underlying lymphoproliferative disorders including lymphoma and leukemia. Eosinophil-... | 2/14/2012 | |
| Management of pancreatic fluid collections a changing of the guard from surgery to endoscopy | The aim of this study was to assess for any trend in management of pancreatic fluid collections (PFCs) and identify impacting factors. The endoscopy and surgical databases were queried for PFC patients. PFCs were categorized as pseudocysts (PP) or complex collections (CC) that included abscess/necro... | 1/26/2012 | |
| Progressive primary sclerosing cholangitis requiring liver transplantation is associated with reduced need for colectomy in patients with ulcerative colitis | CONCLUSIONS: Severe progressive PSC that requires liver transplantation appears to reduce the disease activity of UC and the need for colectomy. | 1/17/2012 | |
| Prevalence and risk factors for colonic perforation during colonoscopy in hospitalized end-stage renal disease patients on hemodialysis | CONCLUSIONS: There appeared no increased risk of colonic perforation during colonoscopy among inpatients who received HD in our study. Increasing age and female patients appeared to be associated with procedure-related colonic perforation. | 12/30/2011 | |
| Pros and cons of medical management of ulcerative colitis | Ulcerative colitis (UC) is a chronic inflammatory disease characterized by diffuse mucosal inflammation limited to the colon and rectum. Although a complete medical cure may not be possible, UC can be treated with medications that induce and maintain remission. The medical management of this disease... | 12/2/2011 | |
| Presence of concomitant inflammatory bowel disease is associated with an increased risk of postcholecystectomy complications | CONCLUSIONS: IBD patients undergoing cholecystectomy have a significantly increased risk of postoperative complications. Although further studies are warranted to clarify the reason for these differences, caution should be taken to determine the need and timing of cholecystectomy in IBD patients. | 11/10/2011 | |
| IgG4-associated ampullitis and cholangiopathy in Crohns disease | Inflammatory bowel disease (IBD) is reported to be associated with autoimmune pancreatitis and IgG4-related sclerosing disease. We report a case of a 28 year old African American male with a long history of upper gastrointestinal tract Crohn's disease (CD) with multiple surgeries who developed medic... | 9/24/2011 | |
| Successful diagnosis and management of biliary cast syndrome in a liver transplant patient using single operator cholangioscopy | CONCLUSION: Single operator cholangioscopy provides a safe means of diagnosing and treating patients with biliary cast syndrome. | 9/10/2011 | |
| Primary sclerosing cholangitis is associated with endoscopic and histologic inflammation of the distal afferent limb in patients with ileal pouch-anal anastomosis | CONCLUSIONS: Concurrent PSC appears to be associated with a significant prepouch ileitis on endoscopy and histology in patients with IPAA. Pouch patients with long segment of ileitis should be evaluated for PSC. | 8/11/2011 | |
| Haemoglobin decreases in NSAID users over time an analysis of two large outcome trials | CONCLUSION: IN these two large, independent trials, clinically-meaningful decreases in haemoglobin ≥ 2 g/dL occurred in a relatively similar fashion over time despite differences in trial designs. | 8/4/2011 | |
| Hepatobiliary disorders and complications of inflammatory bowel disease | One of typical examples of liver-gut cross talk is the interaction and impact of inflammatory bowel disease (IBD) and hepatobiliary (HB) abnormalities on each other's disease course. There are several layers of association between IBD and HB diseases: (i) HB diseases and IBD share pathogenetic mecha... | 7/28/2011 | |
| Endoscopic transmural drainage of peripancreatic fluid collections outcomes and predictors of treatment success in 211 consecutive patients | CONCLUSIONS: Endoscopic therapy is a highly effective technique for the management of patients with non-necrotic peripancreatic fluid collections. | 7/26/2011 | |
| Awareness about clostridium difficile infection among internal medicine residents in the United States | CONCLUSION: IM residents had suboptimal knowledge of many aspects of the common problem of CDI. Educational efforts should be directed at IM residents, many of whom plan careers as primary care/hospitalists, who will encounter patients with CDI. | 7/20/2011 | |
| Single-operator cholangioscopy in patients requiring evaluation of bile duct disease or therapy of biliary stones with videos | CONCLUSIONS: Evaluation of bile duct disease and biliary stone therapy can be safely performed with a high success rate by using the SOC system. | 7/19/2011 | |
| Intra-abdominal fungal infections complicating acute pancreatitis a review | Intra-abdominal infections of pancreatic or peripancreatic necrotic tissue complicate the clinical course of severe acute pancreatitis (SAP) and are associated with significant morbidity. Fungal infection of necrotic pancreatic tissue is increasingly being reported. The incidence of intra-abdominal ... | 7/7/2011 | |
| Elevated serum IgG4 is associated with chronic antibiotic-refractory pouchitis | CONCLUSIONS: Approximately 8% of pouch patients presenting with symptoms of pouch dysfunction to our clinic had elevated serum IgG4. Patients with elevated serum IgG4 were more likely to have CARP. | 7/5/2011 | |
| Prevalence and clinical implications of positive serum anti-microsomal antibodies in symptomatic patients with ileal pouches | CONCLUSIONS: Anti-microsomal antibodies were common in pouch patients presenting with symptoms. Patients with positive anti-microsomal antibodies were much more likely to have concurrent AID and PSC. These patients were more likely to require therapy with steroids. | 7/1/2011 | |
| Mortality associated with gastrointestinal bleeding events Comparing short-term clinical outcomes of patients hospitalized for upper GI bleeding and acute myocardial infarction in a US managed care setting | CONCLUSIONS: GI bleeding events result in significant mortality similar to that of an AMI after adjusting for the initial hospitalization. | 6/23/2011 | |
| Cytomegalovirus ileitis in a patient after liver transplantation-differentiating from de novo IBD | Cytomegalovirus (CMV) infection of the gastrointestinal (GI) tract has been reported in immunocompromised patients and is seen following liver transplantation. Although CMV infection can affect any part of the GI tract, involvement of the terminal ileum is rarely encountered after liver transplantat... | 6/21/2011 | |
| Comprehensive study of cardiovascular morbidity in hospitalized inflammatory bowel disease patients | CONCLUSIONS: Our study substantiates the previously reported associations of mesenteric ischemia and venous thrombotic disorders with IBD. Our study also suggests that young females with IBD might have an increased risk for dysrhythmias. | 6/21/2011 | |
| Durability of radiofrequency ablation in Barretts esophagus with dysplasia | CONCLUSIONS: In subjects with dysplastic BE, RFA therapy has an acceptable safety profile, is durable, and is associated with a low rate of disease progression, for up to 3 years. | 6/18/2011 | |
| Practice of gastroenterologists in treating flaring inflammatory bowel disease patients with clostridium difficile antibiotics alone or combined antibioticsimmunomodulators | CONCLUSIONS: There is significant disagreement among gastroenterologists on whether combination AB+IM or AB alone should be given to IBD patients with CDI-associated flares. Controlled trials are needed to investigate the optimal management approach to this clinical dilemma. | 6/16/2011 | |
| Multiple transluminal gateway technique for EUS-guided drainage of symptomatic walled-off pancreatic necrosis | CONCLUSION: The EUS-guided MTGT is an effective treatment option for the management of symptomatic walled-off pancreatic necrosis because it obviates the need for surgery and endoscopic necrosectomy and its attendant procedure-related morbidity. Prospective studies are required to confirm these prel... | 5/27/2011 | |
| Intraductal papillary mucinous neoplasm and acute pancreatitis | Intraductal papillary mucinous neoplasms (IPMNs) are cystic pancreatic tumors that arise from the pancreatic ducts and are increasingly reported worldwide. Both benign and malignant tumors of the pancreas are thought to contribute to recurrent pancreatitis possibly by pancreatic duct obstruction, an... | 5/24/2011 | |
| Prevalence and risk factors for colonic perforation during colonoscopy in hospitalized inflammatory bowel disease patients | CONCLUSIONS: There appears to be a higher risk of colonoscopy-associated perforation in IBD inpatients than non-IBD controls. In addition, older age, female patients and endoscopic dilations appeared to be associated with an increased risk for perforation. | 5/18/2011 | |
| Frequency of complications during EUS-guided drainage of pancreatic fluid collections in 148 consecutive patients | CONCLUSIONS: Complications are rare during EUS-guided drainage of PFC and can be managed successfully in most patients. | 5/18/2011 | |
| Azathioprine induced pancreatitis in a patient with co-existing autoimmune pancreatitis and hepatitis | CONCLUSIONS: Future studies to investigate the risk of azathioprine induced pancreatitis in the presence of underlying disease of the pancreas including autoimmune pancreatitis are required to further understand the safety of azathioprine in this sub group of patients. | 5/7/2011 | |
| Pediatrics ERCP in children | Although endoscopic retrograde cholangiopancreatography (ERCP) is a well-established technique for both the diagnosis and treatment of biliary and pancreatic disorders in adults, indications for some pediatric applications, such as idiopathic and recurrent pancreatitis, remain contentious. This News... | 4/14/2011 | |
| An LC-ESI-MS method for the quantitative analysis of bile acids composition in fecal materials | In this work, a liquid chromatography coupled with electrospray ionization mass spectrometry (LC-ESI-MS) method was developed and validated for quantification of bile acids in fecal materials. Co-eluting matrix impurities in fecal materials have been shown to greatly suppress the ionization of analy... | 4/6/2011 | |
| Herpes simplex virus hepatitis - its high time we consider empiric treatment | Fulminant hepatitis is an uncommon complication of herpes simplex virus infection. Patients at risk, in particular pregnant women and immunosuppressed patients presenting with fulminant liver failure, receiving delayed acyclovir intervention may lose significant liver parenchyma prompting the need f... | 4/1/2011 | |
| Biliary metal stents are superior to plastic stents for preoperative biliary decompression in pancreatic cancer | CONCLUSIONS: SEMS are superior to plastic stents for preoperative biliary decompression in pancreatic cancer. | 3/5/2011 | |
| Pathogenesis of cholangitis in obstructive jaundice-revisited | Obstructive jaundice produces a number of biochemical and physiologic alterations in the biliary tract. Acute cholangitis occurs in an infected, usually obstructed biliary system, at the level of the common bile duct. The most common cause of obstruction is stones. Bacterial reflux from the biliary ... | 3/5/2011 | |
| Impact of Clostridium difficile infection in patients with ulcerative colitis | CONCLUSIONS: Recent antibiotic exposure was a risk factor for CDI in UC patients. Interestingly, CDI does not seem to adversely affect short-term adverse clinical outcome (colectomy). | 1/29/2011 | |
| Smoking is underrecognized as a risk factor for chronic pancreatitis | CONCLUSIONS: Physicians often underrecognize smoking as a CP risk factor. Efforts are needed to raise awareness of the association between smoking and CP. and IAP. | 1/19/2011 | |
| Zollinger-Ellison syndrome presentation, response to therapy, and outcome | CONCLUSIONS: The clinical presentation of Zollinger-Ellison syndrome was similar to prior reports. Acid hypersecretion was controlled in all patients with variable doses of lansoprazole. Long-term survival was principally related to underlying co-morbidity. | 1/4/2011 | |
| Predicting the probable outcome of treatment in HCV patients | Hepatitis C virus (HCV) is a major cause of chronic liver disease infecting more than 170 million people worldwide. HCV produces a wide gamut of manifestations varying from mild self-limiting disease to cirrhosis and hepatocellular carcinoma. A variety of viral, environmental and host genetic factor... | 12/25/2010 | |
| Type of pain, pain-associated complications, quality of life, disability and resource utilisation in chronic pancreatitis a prospective cohort study | CONCLUSIONS: This is the largest study ever conducted of pain in CP. These findings suggest that the temporal nature of pain is a more important determinant of health-related QOL and healthcare utilisation than pain severity. In contrast to previous studies, the pain associated with CP was not found... | 12/15/2010 | |
| Progress in the management of necrotizing pancreatitis | Pancreatic necrosis, a complication of severe pancreatitis, may become infected, resulting in significant morbidity and potential mortality. Infected necrosis was heretofore considered a surgical condition, and despite aggressive operative management, the mortality remained high. With a better under... | 11/27/2010 | |
| Presentation, response to lansoprazole therapy, and outcome of Zollinger-Ellison syndrome-like gastric acid hypersecretors | CONCLUSIONS: ZES-like gastric acid hypersecretion presents similarly to the classic syndrome. Lansoprazole titrated to gastric acid output is effective in healing mucosal disease and preventing relapse. | 11/16/2010 | |
| Idiopathic hyperammonemia in a patient with total pancreatectomy and islet cell transplantation | CONCLUSION: Idiopathic hyperammonemia in the setting of total pancreatectomy and islet cell transplantation has not been reported before. We propose that malnutrition following total pancreatectomy resulting in repressed urea cycle enzyme synthesis may have predisposed for this hyperammonemia. | 11/12/2010 | |
| Challenges in planning and initiating a randomized clinical study of sphincter of Oddi dysfunction | CONCLUSION: The planning process was challenging, and some changes were needed after initiation. | 11/2/2010 | |
| EUS in patients with surgically altered upper GI anatomy | CONCLUSION: EUS is generally successful and safe in patients with surgically altered anatomy in this tertiary-care setting, and a very low rate of adverse events is possible. Exceptions included imaging the HOP and CBD after Roux-en-Y surgery. After Billroth II surgery, if the afferent limb was intu... | 11/2/2010 | |
| Alcohol and smoking as risk factors in an epidemiology study of patients with chronic pancreatitis | CONCLUSIONS: The frequency of alcohol-related CP at tertiary US referral centers is lower than expected. Idiopathic CP and nonalcohol etiologies represent a large subgroup, particularly among women. Smoking is an independent risk factor for idiopathic CP. | 10/30/2010 | |
| Clostridium difficile infection and inflammatory bowel disease understanding the evolving relationship | Clostridium difficile (C. difficile) infection (CDI) is the leading identifiable cause of antibiotic-associated diarrhea. While there is an alarming trend of increasing incidence and severity of CDI in the United States and Europe, superimposed CDI in patients with inflammatory bowel disease (IBD) h... | 10/19/2010 | |
| Diagnosis and management of pouchitis and ileoanal pouch dysfunction | Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) has become the surgical treatment of choice for patients with medically refractory ulcerative colitis (UC) or UC with dysplasia and for the majority of patients with familial adenomatous polyposis. However, UC patients with IPAA ar... | 10/5/2010 | |
| Quality of life following radiofrequency ablation of dysplastic Barretts esophagus | CONCLUSIONS: Inclusion in the treatment group of this randomized, sham-controlled trial of RFA was associated with improvement in disease-specific health-related quality of life. This improvement appears secondary to a perceived decrease in the risk of cancer. | 10/2/2010 | |
| Effects of compactification in D-brane inflation | In D3-brane inflation, the inflaton potential receives important contributions from sources in the compact space, such as fluxes, other D-branes, and orientifold planes. Most previous analyses have considered only the effects of sources near to the inflationary D3-brane, but in fact distant sources ... | 9/28/2010 | |
| Infectious colitis | PURPOSE OF REVIEW: The incidence of gastrointestinal infections continues to increase and infectious colitis contributes to significant morbidity and mortality worldwide. The purpose of this review is to highlight the recent advances in knowledge of pathogens causing infectious colitis. We describe ... | 9/22/2010 | |
| Prospective evaluation of quality of life in patients with Zollinger-Ellison syndrome | CONCLUSIONS: Patients with medically managed ZES have norm-based estimates of the mental component scores as measured by the SF-36v2 that approximate normal values, while the physical component scores were decreased with this reduction largely explained by co-morbid illness. | 9/9/2010 | |
| Are genetic variants in the platelet-derived growth factor beta gene associated with chronic pancreatitis | CONCLUSIONS: Known variations in the PDGF-[beta] gene do not have a significant effect on promoting or preventing fibrogenesis in pancreatitis. Further evaluation of this important pathway is warranted. | 8/19/2010 | |
| Chronic calcific pancreatitis combination ERCP and extracorporeal shock wave lithotripsy for pancreatic duct stones | CONCLUSIONS: A multidisciplinary approach, combining ERCP and ESWL, to painful obstructing pancreatic duct stones provided symptomatic improvement and allowed pancreatic surgery to be avoided in the majority of patients. | 8/17/2010 | |
| The evolution of endoscopic ultrasound improved imaging, higher accuracy for fine needle aspiration and the reality of endoscopic ultrasound-guided interventions | PURPOSE OF REVIEW: Endoscopic ultrasound (EUS) is one of the fastest growing areas within gastrointestinal endoscopy. Although the growth in the United States has been steady, EUS is exploding in areas of Asia and Eastern Europe. As utilization of EUS is increasing, so is the evolution of the discip... | 8/13/2010 | |
| Low symptomatic premature stent occlusion of multiple plastic stents for benign biliary strictures comparing standard and prolonged stent change intervals | CONCLUSION: Multiple plastic biliary stents for benign nonhilar strictures were associated with a low rate of premature symptomatic stent occlusion at more than 6 months and a longer occlusion-free survival. | 7/20/2010 | |
| Biliary stent placement is associated with post-ERCP pancreatitis | CONCLUSIONS: Bile duct stent placement is an independent predictor for pancreatitis, and pancreatitis is not related to performing sphincterotomy before stenting or to stent characteristics. | 7/17/2010 | |
| Biopsy depth after radiofrequency ablation of dysplastic Barretts esophagus | CONCLUSIONS: In both squamous and columnar tissue, endoscopic biopsy samples after RFA were as likely to demonstrate subepithelium as untreated controls. Almost 80% of all biopsy samples were adequate to evaluate for subsquamous intestinal metaplasia. The primary determinant of biopsy depth is the t... | 7/6/2010 | |
| Endosonographic features predictive of malignancy in mediastinal lymph nodes in patients with lung cancer | CONCLUSION: Among patients with lung cancer, EUS features of round shape, sharp margins, and short axis of >8.3 mm are significant predictors of malignancy. The probability of malignancy is low when none of the features are present. | 6/15/2010 | |
| Somatostatin analogues in the treatment of recurrent bleeding from gastrointestinal vascular malformations an overview and systematic review of prospective observational studies | CONCLUSIONS: A significant number of patients with bleeding gastrointestinal angiodysplasia respond to treatment with octreotide by reducing the need for blood products. As all the included studies had small sample sizes, multicenter randomized trials are needed to confirm these findings. However, i... | 4/16/2010 | |
| Endoscopic retrograde cholangiopancreatography in patients with Roux-en-Y anatomy | Bariatric surgery has been increasingly performed in response to the obesity pandemic. During the last decade, Roux-en-Y gastric bypass (RYGB) has become the preferred surgical approach. It is also commonly performed after pylorus preserving pancreaticoduodenectomy and other biliary tract surgeries.... | 3/6/2010 | |
| Hepatopancreatobiliary manifestations and complications associated with inflammatory bowel disease | Diseases involving the hepatopancreatobiliary (HPB) system are frequently encountered in patients with inflammatory bowel disease (IBD). Hepatobiliary manifestations constitute some of the most common extraintestinal manifestations of IBD. They appear to occur with similar frequency in patients with... | 3/4/2010 | |
| Nutritional support in acute pancreatitis when to start oral feeds | Nutritional support in acute pancreatitis had always been a subject of great controversy in the past. The results of the recently published meta-analysis however have shown improved outcome with enteral feeding when compared to parenteral nutrition in patients with severe acute pancreatitis. However... | 3/2/2010 | |
| Recent advancements in the pathogenesis of pain in chronic pancreatitis the argument continues | Chronic pancreatitis is a state of chronic inflammation characterized by progressive destruction of the pancreas. Pancreatic pain, a cardinal symptom in chronic pancreatitis patients has always been a subject of great interest and controversy. The precise mechanism of pain and its persistence in chr... | 3/2/2010 | |
| Clinical utility of C-reactive protein in patients with ileal pouch anal anastomosis | CONCLUSIONS: Serum CRP levels correlated with endoscopic inflammation in the pouch and afferent limb. Elevated CRP levels might be useful to monitor the degree of inflammatory activity in pouch noninvasively. However, the CRP level as a snapshot had a limited role in distinction between healthy and ... | 2/27/2010 | |
| The economics of upper gastrointestinal bleeding in a US managed-care setting a retrospective, claims-based analysis | CONCLUSIONS: Patients with UGI bleeds experienced significantly higher (p< 0.0001) 12-month health-resource utilization and costs than patients without UGI bleeds. This study provides empirical evidence of the long-term economic burden associated with UGI bleeding. Interpretation of the results shou... | 1/6/2010 | |
| Minimally invasive techniques in pancreatic necrosis | Traditional open surgical necrosectomy for treatment of infected pancreatic necrosis is associated with high morbidity and mortality, leading to a shift toward minimally invasive endoscopic, radiologic, and laparoscopic approaches. Percutaneous drainage is useful as a temporizing method to control s... | 10/27/2009 | |
| Laparoscopy-assisted ERCP experience of a high-volume bariatric surgery center with video | CONCLUSION: LAERCP is safe and successful for the diagnosis and therapy of biliopancreatic conditions in patients with RY. It additionally allows the diagnosis and treatment of internal hernias, a known complication of RYGB. | 10/23/2009 | |
| Pros and cons of antibiotic therapy for pouchitis | Restorative proctocolectomy with ileal pouch-anal anastomosis has become the surgical treatment of choice for patients with medically refractory ulcerative colitis or ulcerative colitis with dysplasia and for the majority of patients with familial adenomatous polyposis. However, pouchitis and other ... | 10/13/2009 | |
| Laparoscopy-assisted transjejunal ERCP in a patient with Roux-en-Y reconstruction following partial gastrectomy | In this article, we report a patient with a history of partial gastrectomy and Roux-en-Y reconstruction who presented with abdominal pain due to sphincter of Oddi dysfunction. After failed endoscopic retrograde cholangiopancreatography (ERCP) through the anatomic route, the procedure was successfull... | 10/2/2009 | |
| Secondary pouchitis those with identifiable etiopathogenetic or triggering factors | Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the surgical treatment of choice for the majority of patients with medically refractory ulcerative colitis (UC) or UC with dysplasia, or familial adenomatous polyposis. Various forms of pouchitis frequently occur after surgery. ... | 9/17/2009 | |
| A randomized trial comparing endoscopic stenting to a sham procedure for chronic pancreatitis | CONCLUSION: The proposed study represents the first trial of endoscopic stenting for symptomatic CP and ductal strictures with a credible sham procedure, assessment of multiple dimensions of pain, and psychosocial factors. | 9/10/2009 | |
| Laboratory tests for patients with ileal pouch-anal anastomosis clinical utility in predicting, diagnosing, and monitoring pouch disorders | Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the surgical treatment of choice for patients with medically refractory ulcerative colitis (UC) or UC-associated dysplasia, and for the majority of patients with familial adenomatous polyposis. Pouchitis and other complications ... | 7/16/2009 | |
| Costs and risks in the management of patients with gastric acid hypersecretion | CONCLUSIONS: Relapse is infrequent and generally mild with acid secreting status closely monitored. The ideal strategy to balance costs and testing awaits further study. | 7/8/2009 | |
| Distinguishing tuberculosis and Crohns disease in developing countries how certain can you be of the diagnosis | Distinguishing tuberculosis and Crohn's disease in patients presenting with chronic abdominal pain and diarrhea is a huge diagnostic challenge, particularly in tuberculosis endemic countries. A large number of patients with Crohn's disease are initially misclassified as having Intestinal tuberculosi... | 7/2/2009 | |
| Risk factors for abnormal liver function tests in patients with ileal pouch-anal anastomosis for underlying inflammatory bowel disease | CONCLUSIONS: Abnormal LFTs were common in patients with IPAA in this cohort. The presence of co-existing autoimmune disorder, a family history of IBD, extensive colitis before colectomy, the presence of PSC, and a high BMI appear to be a significant risk factors for abnormal LFTs. Whether abnormal L... | 6/25/2009 | |
| Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancreatitis | CONCLUSIONS: Very heavy alcohol consumption and smoking are independent risks for CP. A minority of patients with pancreatitis currently seen at US referral centers report very heavy drinking. | 6/10/2009 | |
| Comparative performance of uncoated, self-expanding metal biliary stents of different designs in 2 diameters final results of an international multicenter, randomized, controlled trial | CONCLUSIONS: SEMS occlusions were much more frequent with a 6-mm diameter SEMS and equivalent in the two 10-mm arms despite major differences in stent design, material, and expansion, suggesting that diameter is the critical feature. Malignant tumor ingrowth produced only a minority of the documente... | 6/2/2009 | |
| Radiofrequency ablation in Barretts esophagus with dysplasia | CONCLUSIONS: In patients with dysplastic Barrett's esophagus, radiofrequency ablation was associated with a high rate of complete eradication of both dysplasia and intestinal metaplasia and a reduced risk of disease progression. (ClinicalTrials.gov number, NCT00282672.) | 5/29/2009 | |
| Clinical trials of pancreatic enzyme replacement for painful chronic pancreatitis--a review | Painful chronic pancreatitis is a challenging problem for clinicians and patients. Many patients receive a therapeutic trial of pancreatic enzyme supplementation at some point in the course of their disease, but it is unclear what the expected outcome of such a trial should be and whether or not all... | 5/20/2009 | |
| Outcome of esophageal carcinoma in the veteran affairs population a comparative analysis from the Veteran Affairs Central Cancer Registry | CONCLUSIONS: In nonmetastatic esophageal cancer at the VA, SCC has worse outcome as compared with AC. Blacks with AC have worse outcome than whites. Despite equal access to health care blacks are less likely to undergo surgery, which may contribute to their worse outcome. We recommend further studie... | 5/13/2009 | |
| Treatment strategies for Zollinger-Ellison syndrome | BACKGROUND: Zollinger-Ellison syndrome (ZES) is a rare disorder caused by tumor secretion of the hormone gastrin, which results in gastric acid hypersecretion and secondarily complicated peptic ulcer and diarrhea. Until the development of H(2)-receptor antagonists and later proton pump inhibitors (P... | 4/9/2009 | |
| Thinking beyond the colon-small bowel involvement in clostridium difficile infection | Small intestinal Clostridium difficile seems to be increasing in incidence. The spectrum of Clostridium difficile infection (CDI) has definitely expanded with small bowel involvement. They are more frequently reported in patients with inflammatory bowel disease (IBD) who have undergone total colecto... | 4/3/2009 | |
| Risk factors for gastric cancer in South India | CONCLUSION: The study showed alcohol and pickled food consumption as independent risk factors for the development of gastric cancer, while consumption of pulses were protective. Cigarette smoking did not predict an increased risk of contracting the disease. | 3/20/2009 | |
| Hypertriglyceridemic pancreatitis presentation and management | Hypertriglyceridemia (HTG) is reported to cause 1-4% of acute pancreatitis (AP) episodes. HTG is also implicated in more than half of gestational pancreatitis cases. Disorders of lipoprotein metabolism are conventionally divided into primary (genetic) and secondary causes, including diabetes, hypoth... | 3/19/2009 | |
| Post-ERCP pancreatitis rates do not differ between needle-knife and pull-type pancreatic sphincterotomy techniques a multiendoscopist 13-year experience | CONCLUSIONS: The risk of post-ERCP pancreatitis does not differ between EPS techniques when performed at a high-volume pancreaticobiliary referral center when using routine prophylactic pancreatic duct stent placement. | 2/28/2009 | |
| Modern endoscopic therapy of peptic ulcer bleeding | Acute upper gastrointestinal bleed (UGIB) remains a challenging clinical problem owing to significant patient morbidity and costs involved with management. Peptic ulcer bleeding (PUB) contributes to the majority of causes of UGIB with a growing concern of its impact on the elderly and the increasing... | 2/4/2009 | |
| Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts a report of the PANDA study | CONCLUSIONS: Elevated amounts of pancreatic cyst fluid DNA, high-amplitude mutations, and specific mutation acquisition sequences are indicators of malignancy. The presence of a k-ras mutation is also indicative of a mucinous cyst. DNA analysis should be considered when cyst cytologic examination is... | 1/21/2009 | |
| Appropriateness of indications for diagnostic upper gastrointestinal endoscopy in India | CONCLUSION: In the south Indian population with dyspepsia, there were more normal and benign lesions at endoscopy. The optimal cut-off ages for detecting malignancy for both genders were also determined. | 1/6/2009 | |
| Diagnosis amp; management of cytomegalovirus infections in the GI tract | Cytomegalovirus (CMV) infection of the GI tract is a common problem in patients immunosuppressed by HIV or organ transplantation. The esophagus and colon are the most common sites of involvement. Recent developments in diagnosis, such as immunohistochemical staining, shell vial assay and PCR, aid in... | 12/17/2008 | |
| Acquired platelet dysfunction with spontaneous intramuscular hematoma and compartment syndrome in cirrhosis | Cirrhosis patients are at high risk for bleeding as a result of decreased platelet counts and impaired function, defective production of coagulation factors and abnormalities in clot lysis. The authors report the case of a 58 year-old man with cryptogenic cirrhosis who presented initially with intra... | 12/3/2008 | |
| Gastrointestinal imaging in HIV | Gastrointestinal opportunistic disorders are common in HIV-infection and are often the index AIDS-defining opportunistic illness. Almost 80% of HIV-infected patients experience gastrointestinal (GI) symptoms at some point during the course of their illness, and the incidence of GI disorders increase... | 11/29/2008 | |
| Short-term discontinuation of HAART regimens more common in vulnerable patient populations | The durability of HAART regimens is often limited by antiretroviral toxicity and nonadherence, which lead to virologic failure. We sought to determine sociodemographic and psychosocial patient factors predictive of short-term discontinuation of HAART regimens overall and stratified by the reason for... | 11/27/2008 | |
| Multiple gastrointestinal stromal tumors and lipomatosis | In this report, we describe a 36-year-old man with the synchronous occurrence of multiple gastric gastrointestinal stromal tumors and multiple intestinal lipomas. Multiple, small, and well-circumscribed gastric gastrointestinal stromal tumors (3 mm to 2 cm) were present within the gastrectomy specim... | 11/4/2008 | |
| Cost minimization analysis comparing diagnostic strategies in unexplained pancreatitis | CONCLUSIONS: This cost minimization study identifies EUS as the least costly initial test for the diagnostic evaluation of patients with idiopathic pancreatitis with gallbladder in situ. | 10/15/2008 | |
| Mechanisms of infectious diarrhea | Infectious diarrhea is an important public health problem worldwide. Research has provided new insights into the mechanisms of diarrhea caused by various pathogens that are classified as noninflammatory, inflammatory or invasive. These three groups of organisms cause two diarrheal syndromes--noninfl... | 9/25/2008 | |
| Multicenter approach to recurrent acute and chronic pancreatitis in the United States the North American Pancreatitis Study 2 NAPS2 | CONCLUSION: The NAPS2 consortium has successfully completed a prospective ascertainment of 1,000 subjects with RAP and CP from the USA. These data will be useful in elucidating the environmental, metabolic and genetic conditions, and to investigate the complex interactions that underlie RAP and CP. | 9/4/2008 | |
| Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population role of serine protease inhibitor Kazal 1type and alcohol | CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a significant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | 8/6/2008 | |
| Hepatitis E and pregnancy understanding the pathogenesis | Hepatitis E virus (HEV) is a single-stranded RNA virus that causes large-scale epidemics of acute viral hepatitis, particularly in developing countries. In men and non-pregnant women, the disease is usually self-limited and has a case-fatality rate of less than <0.1%. However, in pregnant women, par... | 7/30/2008 | |
| Prospective randomized trial comparing EUS and EGD for transmural drainage of pancreatic pseudocysts with videos | CONCLUSIONS: When available, EUS should be considered as the first-line treatment modality for endoscopic drainage of pancreatic pseudocysts given its high technical success rate. | 7/22/2008 | |
| Should patients undergoing ERCP be placed in the prone or supine position | Endoscopic retrograde cholangiopancreatography (ERCP) is generally performed in the prone or semi-prone position. Compared with the supine position, the left lateral and prone positions are believed to carry a lower risk of aspiration, allow easier intubation of the esophagus and provide a more comf... | 7/17/2008 | |
| Endoscopic resection of minor papilla adenomas with video | CONCLUSIONS: In experienced hands, endoscopic resection of the minor papilla is technically feasible, safe, and is associated with favorable clinical outcomes. | 6/28/2008 | |
| EUS versus surgical cyst-gastrostomy for management of pancreatic pseudocysts | CONCLUSIONS: EUS-guided cyst-gastrostomy should be considered as a first-line treatment approach for patients with uncomplicated pancreatic pseudocysts, because the procedure is cost saving and is associated with a shorter length of a postprocedure hospital stay when compared with surgical cyst-gast... | 6/13/2008 | |
| Absence of gastrointestinal infections in a cohort of patients with Zollinger-Ellison syndrome and other acid hypersecretors receiving long-term acid suppression with lansoprazole | CONCLUSION: In a cohort of patients with gastric acid hypersecretion in whom acid secretion status was monitored on lansoprazole, all were free of significant gastrointestinal infections on long-term follow-up. | 5/30/2008 | |
| Acute renal failure in snake envenomation a large prospective study | Venomous snakebite is a common problem in India. The aim of this study is to assess the prevalence, risk factors and prognostic factors in snakebite induced acute renal failure and to determine their outcome from a tertiary care center in India. A total of 1548 cases of snakebite admitted to adult m... | 5/1/2008 | |
| The concept of bedside EUS | CONCLUSIONS: Bedside EUS is technically feasible, safe, facilitates both diagnosis and therapy, and enables the clinical management of patients who are critically ill. | 4/22/2008 | |
| Value of repeat endoscopic ultrasound-guided fine needle aspiration for suspected pancreatic cancer | CONCLUSION: Repeat EUS-FNA is warranted in patients with high clinical suspicion for pancreatic cancer despite indeterminate or negative findings at initial EUS-FNA. | 4/10/2008 | |
| Transition from laboratory to clinical practice in NOTES role of NOSCAR | The way to move natural orifice translumenal endoscopic surgery (NOTES) from the laboratory to the clinical arena is to do high-quality research in the areas recommended by the NOSCAR working group representing barriers to NOTES procedures. Additionally, good experimental work needs to be done to de... | 4/3/2008 | |
| Endoscopic management of biliary leaks The answer for the future | Bile duct diseases and biliary leaks are not uncommon complications and their management is challenging. Majority of bile leaks occur secondary to trauma, major liver, gallbladder and biliary tract surgeries. Early recognition of bile leaks by imaging combined with a high clinical suspicion is requi... | 3/6/2008 | |
| Protocol-based medical management of post-ERCP pancreatitis | CONCLUSIONS: A protocol-based management strategy was associated with less severe pancreatitis, shorter length of hospital stay, need for fewer imaging studies, and use of antibiotics. Prospective validation of these findings is justified. | 3/6/2008 | |
| Herbal drugs in liver disease how safe are they | A 24-year-old man presented with jaundice to our center and further evaluation revealed the presence of acute hepatitis E infection, an infection common in India. The patient's parents consulted a traditional medicine practitioner for giving him native medications for jaundice, a practice very commo... | 2/28/2008 | |
| Pilot study of transesophageal endoscopic epicardial coagulation by submucosal endoscopy with the mucosal flap safety valve technique with videos | CONCLUSIONS: The SEMF technique allowed endoscopic access to the upper mediastinum, the pericardium, and the epicardium via the esophagus, along with a minimal intervention on the epicardium. | 2/26/2008 | |
| Gastrointestinal complications of HIV infection changing priorities in the HAART era | It has now been some 25 years since the initial description of AIDS. Following these observations, the epidemiology, natural history and manifestations of this disease have been well characterised. Intense investigation has better characterised HIV, resulting in the development of effective drug the... | 1/22/2008 | |
| Advantages and limitations of endoscopic ultrasonography in the evaluation and management of patients with gastrointestinal submucosal tumors a review | Conventional endoscopy can assess the location, mucosal appearance, and consistency of a gastrointestinal submucosal tumor but cannot provide enough information to differentiate the tumor from extraluminal compression by an external structure or from a neoplastic lesion or to determine whether the t... | 1/15/2008 | |
| Prospective evaluation of indeterminate ERCP findings by intraductal ultrasound | CONCLUSIONS: A technically easy procedure, IDUS offers unique advantages in the evaluation of patients with indeterminate findings at ERCP. | 11/23/2007 | |
| A new stapler-based full-thickness transgastric access closure results from an animal pilot trial | CONCLUSIONS: Gastrotomy closure with a perorally delivered flexible stapling device created a leak-resistant transmural line of staples followed by full-thickness healing of the gastric wall incision. Increasing the length of the instrument and adding device articulation will further facilitate its ... | 10/31/2007 | |
| Preliminary pneumoperitoneum facilitates transgastric access into the peritoneal cavity for natural orifice transluminal endoscopic surgery a pilot study in a live porcine model | CONCLUSIONS: Creation of a preliminary pneumoperitoneum with a Veress needle facilitates gastric wall puncture and entrance into the peritoneal cavity without injury to adjacent organs, and can improve the safety of NOTES. | 10/31/2007 | |
| Ethical and medicolegal issues related to percutaneous endoscopic gastrostomy placement | Enteral nutrition, in many respects more than other medical interventions, has been in the limelight concerning the ethics of withdrawing or withholding nutritional support. This article describes the ethical and legal issues surrounding enteral nutrition, identifies the elements of informed consent... | 10/31/2007 | |
| Role of EUS in drainage of peripancreatic fluid collections not amenable for endoscopic transmural drainage | CONCLUSIONS: Because a majority of PFCs can be drained by CTD in a shorter duration, with comparable outcomes, EUS-guided drainage should be reserved mainly for PFCs located at the pancreatic tail, because these are unlikely to cause luminal compression or are technically difficult to access. Also, ... | 9/26/2007 | |
| Small prophylactic pancreatic duct stents an assessment of spontaneous passage and stent-induced ductal abnormalities | CONCLUSIONS: Nearly 90 % of prophylactic 3-Fr pancreatic duct stents pass spontaneously within 30 days, and these stents were not observed to induce changes in the pancreatic duct. | 9/22/2007 | |
| Erythromycin prior to endoscopy for acute upper gastrointestinal haemorrhage a cost-effectiveness analysis | CONCLUSION: Because of the implications for cost saving and increase in QALY, we would recommend giving erythromycin prior to EGD for UGIH. | 9/13/2007 | |
| Submucosal endoscopic esophageal myotomy a novel experimental approach for the treatment of achalasia | CONCLUSIONS: Endoscopic submucosal esophageal myotomy is feasible, safe, and effective in the short term. It has the potential for being useful in patients with achalasia. The submucosal space is a novel and potentially important field of operation for endoscopic procedures. | 8/21/2007 | |
| Health-related quality of life, somatization, and abuse in Sphincter of Oddi dysfunction | CONCLUSIONS: Health-related quality of life is impaired and abuse histories are common in SOD patients, and similar to patients with recurrent idiopathic pancreatitis. Whether these characteristics are predictors of healthcare seeking remains to be determined. | 8/19/2007 | |
| Advanced endoscopy and endosurgical procedures do we need a new subspecialty | On the horizon is a new paradigm in minimally invasive therapy called natural orifice transluminal endoscopic surgery (NOTES). This new approach will most certainly disrupt both those living in the gut lumen with flexible endoscopes as well as those living in the peritoneal cavity using laparoscopes... | 7/21/2007 | |
| Aspirin chemoprevention in patients with increased risk for colorectal cancer a cost-effectiveness analysis | CONCLUSION: Aspirin chemoprevention combined with colonoscopic surveillance in post-polypectomy patients may be considered a cost-effective strategy. | 7/20/2007 | |
| Prospective evaluation of adjunctive ketamine on sphincter of Oddi motility in humans | CONCLUSIONS: Ketamine at 20 mg did not significantly affect SOM parameters. Further studies are required to confirm our preliminary findings before ketamine can be added to the armamentarium of agents used for performance of sphincter of Oddi manometry. | 6/27/2007 | |
| Endoscopic management of traumatic bile leaks | CONCLUSIONS: Consideration should be given to incorporate ERCP as first-line therapy in management of traumatic bile leaks, because endobiliary stent placement provides a successful outcome in a majority of cases, irrespective of the severity of injury. | 5/29/2007 | |
| Transgastric cholecystectomy transgastric accessibility to the gallbladder improved with the SEMF method and a novel multibending therapeutic endoscope | CONCLUSIONS: Transgastric cholecystectomy is technically feasible. Transgastric access to the gallbladder may be improved by using submucosal endoscopy with an offset exit gastrotomy by means of the mucosal flap safety-valve technique and a multibending gastroscope. | 5/29/2007 | |
| Peroral transgastric endoscopic primary repair of a ventral hernia in a porcine model | CONCLUSIONS: Transgastric endoscopic primary repair of ventral hernias in a porcine model is feasible and may be technically simpler than laparoscopic surgery. | 5/23/2007 | |
| Endoscopic ultrasound a meta-analysis of test performance in suspected biliary obstruction | CONCLUSIONS: There is excellent overall accuracy for EUS in diagnosing choledocholithiasis, with less impressive results for malignancy (when fine-needle aspiration is not used). | 5/5/2007 | |
| Diagnostic performance of EUS for chronic pancreatitis a comparison with histopathology | CONCLUSIONS: A threshold of 3 or more EUS criteria provides the best balance of sensitivity and specificity for histologic pancreatic fibrosis. Calcifications seen by EUS but missed by other imaging are common in this group of patients. | 5/1/2007 | |
| Safety and success of precut biliary sphincterotomy Is it linked to experience or expertise | CONCLUSION: Despite the lack of specific training in this technique, PBS was performed with a high success rate and a complication rate similar to or less than reports from other experienced centers. These results suggest that endoscopic experience and perhaps innate endoscopic skill may play an imp... | 5/1/2007 | |
| A prospective evaluation of an algorithm incorporating routine preoperative endoscopic ultrasound-guided fine needle aspiration in suspected pancreatic cancer | CONCLUSIONS: EUS-FNA is a safe and highly accurate method for tissue diagnosis in suspected pancreatic cancer. This approach allows for preoperative counseling of patients, minimizing surgeon's operative time in cases of unresectable disease, and avoids surgical biopsies in the majority of patients ... | 4/19/2007 | |
| Prospective randomized trial evaluating ketamine for advanced endoscopic procedures in difficult to sedate patients | CONCLUSIONS: Ketamine is a useful adjunct to conscious sedation in patients who are difficult to sedate. Its use Results in better quality and depth of sedation with shorter recovery times than patients sedated using benzodiazepines and meperidine alone. Further prospective studies evaluating the ef... | 4/4/2007 | |
| Technical feasibility of endoscopic gastric reduction a pilot study in a porcine model | CONCLUSIONS: Endoscopic gastric reduction is technically feasible on a live porcine model. | 2/27/2007 | |
| A novel safe approach to the peritoneal cavity for per-oral transgastric endoscopic procedures | CONCLUSIONS: The PEG-like transgastric approach to the peritoneal cavity appears technically simple and safe. | 2/27/2007 | |
| The expanding role of endoscopic ultrasound in pancreatic disease | Since endoscopic ultrasound (EUS) was first developed in the 1980s, this technology has emerged as the principal modality for imaging the pancreas. When compared with other imaging techniques, EUS can more accurately image solid lesions of the pancreas and determine vascular involvement that might p... | 1/17/2007 | |
| Pilot study of the porcine uterine horn as an in vivo appendicitis model for development of endoscopic transgastric appendectomy | CONCLUSIONS: This preliminary study demonstrated the technical feasibility to create a model for acute appendicitis by using the porcine uterine horn and transgastric appendectomy. | 10/24/2006 | |
| Randomized trial comparing needle-knife and pull-sphincterotome techniques for pancreatic sphincterotomy in high-risk patients | CONCLUSIONS: Pancreatic sphincterotomy is safer in high-risk patients when performed with a needle knife over a pancreatic stent. | 10/24/2006 | |
| Gastrointestinal infections in children | Gastrointestinal infections in children are a major cause of morbidity and mortality worldwide. Children living in developing countries are particularly susceptible to infectious diarrhea because of poor standards of hygiene and sanitation. Although the magnitude of diarrheal illnesses in developed ... | 10/13/2006 | |
| Best of DDW 2006 | Highlights from the 2006 Digestive Disease Week May 20-25, 2006, Los Angeles, CA. In this meeting review, many of our editorial board members report on Digestive Disease Week 2006. They highlight the most noteworthy presentations in their respective areas of expertise, including the latest treatment... | 9/8/2006 | |
| Relationship among hospital ERCP volume, length of stay, and technical outcomes | CONCLUSIONS: Inpatients who undergo ERCP at high-volume hospitals have shorter LOS and lower procedural failure rates than those undergoing ERCP at low-volume hospitals. These findings have important implications for health care policy decision making and resource utilization. | 8/23/2006 | |
| Prognostic factors for survival in pancreatic cancer a population-based study | CONCLUSIONS: Survival in patients with pancreatic cancer remains dismal. Tumor characteristics and treatment factors are related directly to survival time in patients with pancreatic cancer. Black patients were less likely to receive therapy but also were more likely to refuse the indicated therapy.... | 8/22/2006 | |
| Prospective endoscopic evaluation for gastrointestinal graft-versus-host disease determination of the best diagnostic approach | The best endoscopic diagnostic strategy for gastrointestinal (GI) graft-versus-host disease (GVHD) is unknown. Over a 48-month period, all patients with unexplained diarrhea at risk for acute gastrointestinal GVHD were prospectively identified. Acute GVHD was defined as symptoms and histologic evide... | 8/18/2006 | |
| Immediate endoscopic closure of colon perforation by using a prototype endoscopic suturing device feasibility and outcome in a porcine model with video | CONCLUSIONS: Closure of acute perforation of the colon is feasible with the Eagle Claw endoscopic suturing device in a porcine model. | 7/4/2006 | |
| The endoscopic transilluminator an endoscopic device for identification of the proximal jejunum for transgastric endoscopic gastrojejunostomy | CONCLUSIONS: The ET is a safe instrument and can be used to identify the proximal jejunum to facilitate endoscopic gastrojejunostomy. | 5/31/2006 | |
| Role of endoscopic evaluation in idiopathic pancreatitis a systematic review | In approximately 20% of patients with acute pancreatitis, a cause is not established by history, physical examination, routine laboratory testing, and abdominal imaging. For those with a single unexplained attack, the role of invasive evaluation with endoscopic retrograde cholangiopancreatography is... | 5/31/2006 | |
| Endoscopic management of sphincter of Oddi dysfunction in children | CONCLUSIONS: As in adults, pancreatic and dual sphincterotomy, in expert hands, is effective and safe in a subgroup of children with SOD. Prospective, randomized trials with larger number of patients are required to validate the efficacy of endotherapy in children with SOD. | 5/19/2006 | |
| Gastrointestinal Considerations in Patients with Cardiovascular Disease Using Nonopioid Analgesics for Mild-to-Moderate Pain or Cardioprotection | Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most widely used classes of medications worldwide, available both through prescription and over the counter (OTC). Although these drugs are highly effective for pain, gastrointestinal (GI) complications may occur. Risk factors for GI compli... | 5/6/2006 | |
| The MCP-1 -2518 AG polymorphism is not a susceptibility factor for chronic pancreatitis | CONCLUSIONS: Although the pro-inflammatory chemokine MCP-1 -2518 G allele is a severity factor for AP, it does not significantly alter susceptibility to CP. | 4/26/2006 | |
| Frequency of major complications after EUS-guided FNA of solid pancreatic masses a prospective evaluation | CONCLUSIONS: EUS-FNA of solid pancreatic masses infrequently leads to major complications. Our results can be used by endosonographers to counsel patients before EUS-FNA of solid pancreatic masses. | 3/28/2006 | |
| Do all patients with abnormal intraoperative cholangiogram merit endoscopic retrograde cholangiopancreatography | CONCLUSIONS: One-third of patients with an abnormal IOC have a normal postoperative ERCP. Elevated liver function tests can help to identify patients who merit further evaluation by ERCP. The use of less invasive methods such as endoscopic ultrasound or magnetic resonance cholangiopancreatography sh... | 3/18/2006 | |
| Endoscopic therapy for chronic pancreatitis an evidence-based review | In the setting of chronic pancreatitis, pancreatic ductal obstruction, and ductal leak, pseudocyst formation and biliary obstruction present many challenges for endoscopists. Although chronic pancreatitis has a variety of clinical manifestations, most commonly patients present with intermittent or c... | 3/15/2006 | |
| Economical and clinical outcomes of alternative treatment strategies in the management of common bile duct stones in the elderly wait and see or surgery | CONCLUSIONS: In patients aged 60 and older, expectant management after ERC-S for CBDS is a reasonable approach, but the economic attractiveness of this strategy is highly dependent on the probability of recurrent symptoms. | 2/24/2006 | |
| Outcomes of cholecystectomy after endoscopic sphincterotomy for choledocholithiasis | Laparoscopic cholecystectomy (LC) for treatment of symptomatic common bile duct stones (CBDS) after endoscopic sphincterotomy (ES) is associated with increased conversion and complications compared with other indications. We examined factors associated with conversion and complications of LC after E... | 2/4/2006 | |
| Transgastric endoscopic splenectomy is it possible | CONCLUSIONS: Transgastric endoscopic splenectomy in a porcine model appears technically feasible. Additional long-term survival experiments are planned. | 1/25/2006 | |
| Patterns of use and public perception of over-the-counter pain relievers focus on nonsteroidal antiinflammatory drugs | CONCLUSION: OTC analgesics including NSAID are widely used, are frequently taken inappropriately and potentially dangerously, and users are generally unaware of the potential for adverse side effects. Educational intervention directed toward both patients and physicians appears warranted. | 11/3/2005 | |
| Biochemical analysis of pancreatic fluid collections predicts bacterial infection | CONCLUSIONS: Biochemical analysis of PFC fluid is clinically helpful in detecting fluid infection in patients with bacteria on Gram stain or positive fluid cultures. Our findings fail to support the utility of fluid analysis in characterizing cyst type, and we caution against its use in distinguishi... | 10/26/2005 | |
| Gastrointestinal manifestations of AIDS | Although gastrointestinal complications have decreased dramatically in patients with acquired immunodeficiency syndrome (AIDS) who received highly active antiretroviral therapy, these disorders still occur in those who do not seek healthcare, those with resistant virus, and those in developing count... | 10/11/2005 | |
| Cytologic grade independently predicts survival of patients with pancreatic adenocarcinoma | Our objectives were to devise a cytologic grading system and determine whether it would predict survival of patients with solid-type pancreatic adenocarcinoma. We evaluated 116 consecutive patients from July 2000 to November 2002; they were followed up until September 2003. We scored the following f... | 10/6/2005 | |
| Developing an animal model of massive ulcer bleeding for assessing endoscopic hemostatic devices | CONCLUSION: This animal model provides reproducible massive hemorrhage suitable for endoscopic studies. Control of gastric bleeding from large arteries by endoscopic suturing is possible. | 8/24/2005 | |
| Endoscopic gastrojejunostomy with survival in a porcine model | CONCLUSIONS: The endoscopic transgastric approach to create a gastrojejunostomy is technically feasible and can be performed, with survival, in a porcine model. | 7/28/2005 | |
| Eagle Claw II A novel endosuture device that uses a curved needle for major arterial bleeding a bench study | CONCLUSIONS: Control of bleeding from large arteries by using endoscopic suturing is possible. Continued refinements of the device are required. | 7/28/2005 | |
| Impact of EUS in the evaluation of pancreaticobiliary disorders in children | CONCLUSIONS: EUS and EUS-guided FNA are feasible, safe, and have significant impact that alters subsequent management in the majority of children with PB disorders. Further studies and dissemination of information is required to facilitate its increased application in children. | 7/28/2005 | |
| Endoscopic suturing without extracorporeal knots a laboratory study | CONCLUSIONS: The present prototype represents significant improvements in the ease of operation and the security of the suture, bringing the technique closer to clinical use for a variety of applications. | 7/28/2005 | |
| Assessing the adequacy of endoscopically tied knots a functional approach | CONCLUSIONS: This system is a reliable model for testing intracorporeal knots tied endoscopically. A three-half-hitches square knot with 3/0 nylon, tied using a flexible endoscope and knot-tightening cap, can withstand pressure up to 200 mm Hg. | 4/22/2005 | |
| Transoral obesity surgery endoluminal gastroplasty with an endoscopic suture device | CONCLUSIONS: In a bench model, it is technically possible to accomplish transoral gastroplasty endoscopically with an intraluminal suturing device. Further live animal studies will be needed in order to confirm the efficacy and safety of this procedure before clinical application. | 4/22/2005 | |
| Predictors of outcome in pancreatic duct disruption managed by endoscopic transpapillary stent placement | CONCLUSIONS: Successful resolution of PD disruption by transpapillary stent insertion depends on the type of disruption and the ability to bridge the disrupted duct with a stent. | 4/7/2005 | |
| Peroral transgastric endoscopic ligation of fallopian tubes with long-term survival in a porcine model | CONCLUSIONS: The peroral endoscopic transgastric approach to ligation of the Fallopian tubes with long-term survival is technically feasible and safe in a porcine model. The endoscopic transgastric approach to the peritoneal cavity has potential for a wide array of diagnostic and therapeutic procedu... | 3/11/2005 | |
| Occurrence of gastrointestinal opportunistic disorders in AIDS despite the use of highly active antiretroviral therapy | Since the introduction of highly active antiretroviral therapy (HAART), the frequency of opportunistic disorders (ODs) of the gastrointestinal (GI) tract in human immunodeficiency virus (HIV)-infected patients has fallen dramatically. We have found, however, that despite the use of HAART, HIV-infect... | 3/5/2005 | |
| Principles of endosonography and imaging | Accurate interpretation of ultrasound images requires knowledge of the principles of ultrasound and how it interacts with tissue. This article outlines the important principles that every endosonographer should know and provides clinical implications to make the material relevant to endosonographers... | 11/24/2004 | |
| Widespread EMR a new technique for removal of large areas of mucosa | CONCLUSIONS: Wide EMR appears to be technically feasible for removal of large areas of mucosa. Mucosal strips 5 cm long that included over 50% of the luminal circumference were resected safely. Resection was followed by complete regrowth of the mucosa. However, a second wide EMR to create a circumfe... | 10/9/2004 | |
| Endoscopic ultrasound-guided fine-needle aspiration biopsy a powerful tool to obtain samples from small lesions | CONCLUSIONS: EUS-FNAB was a highly effective technique to obtain samples from small (< or = 25 mm) and large (> 25 mm) lesions without affecting the sensitivity, specificity, or diagnostic accuracy. | 9/16/2004 | |
| Efficiency issues in sedation and monitoring | Sedation and monitoring are key elements of the endoscopy process. There continues to be intense study of better methods for sedation and monitoring to improve the endoscopic "experience" for both patient and physicians alike. Our current practices will likely change in the future with technologic a... | 9/15/2004 | |
| Is endosonography guided fine needle aspiration EUS-FNA for sarcoidosis as good as we think | CONCLUSIONS: EUS-FNA is an accurate method for diagnosing sarcoidosis in an unselected group of patients with mediastinal lymphadenopathy. The reported sensitivity and specificity must be appreciated in the context of the difficult and often incomplete clinical diagnosis of sarcoidosis. | 8/31/2004 | |
| Acute pancreatitis after EUS-guided FNA of solid pancreatic masses a pooled analysis from EUS centers in the United States | CONCLUSIONS: EUS-guided FNA of solid pancreatic masses is infrequently associated with acute pancreatitis. The procedure appears to be safe when performed by experienced endosonographers. The frequency of post EUS-guided FNA pancreatitis may be underestimated by retrospective analysis. | 8/28/2004 | |
| Technical outcomes and complications of ERCP in children | CONCLUSIONS: When ERCP is performed in children by expert endoscopists, the success rate is high and the complication rate is low, both being comparable with those for ERCP in adult patients. | 8/28/2004 | |
| EUS-guided FNA of lung masses adjacent to or abutting the esophagus after unrevealing CT-guided biopsy or bronchoscopy | CONCLUSIONS: In this study, EUS-guided FNA of lung mass was safe, and it established a diagnosis in all patients with accessible lesions. Given these preliminary data, a prospective evaluation of this new indication for EUS-guided FNA is justified. | 7/28/2004 | |
| Endoscopic ultrasonography in the diagnosis and staging of neoplasms of the head and neck | CONCLUSIONS: EUS with FNA provides a viable approach to the diagnosis and staging of tumors in the head and neck region when there is a suggestion of esophageal invasion on CT or MRI, or enlarged mediastinal lymph nodes. EUS with FNA may avoid the need for mediastinoscopy or other more invasive tech... | 7/10/2004 | |
| Prospective comparison of brush cytology, viral culture, and histology for the diagnosis of ulcerative esophagitis in AIDS | CONCLUSIONS: Viral culture and cytologic brushings add little to the evaluation of esophageal ulcers in patients with AIDS over multiple biopsy specimens with routine histology. | 6/30/2004 | |
| Assessment of health state utilities and quality of life in patients with malignant esophageal Dysphagia | CONCLUSIONS: These results confirm the perceived poor state of health of patients with esophageal cancer and are substantially lower than previous estimates in operated patients. Cost-effectiveness models must take into account significant differences between patients' assessment of their own state ... | 6/8/2004 | |
| Re-examination of the cost-effectiveness of surgical versus medical therapy in patients with gastroesophageal reflux disease the value of long-term data collection | CONCLUSIONS: Long-term medical therapy with proton pump inhibitors is the preferred strategy for patients with gastroesophageal reflux disease and severe esophagitis. Our study highlights the importance of using primary, patient-derived data rather than expert opinion. | 6/8/2004 | |
| EUS-guided FNA of the left adrenal gland in patients with thoracic or GI malignancies | CONCLUSIONS: EUS-guided FNA of the left adrenal gland is a minimally invasive, safe, and highly accurate method that confirms or excludes malignant adrenal involvement in patients with thoracic or GI malignancies. | 4/29/2004 | |
| Endoscopic ultrasound in lung cancer patients with a normal mediastinum on computed tomography | CONCLUSIONS: Endoscopic ultrasound guided fine needle aspiration can detect advanced mediastinal disease and avoid unnecessary surgical exploration in almost one of four patients who have no evidence of mediastinal disease on CT scan. In addition to previously reported results in patients with enlar... | 4/28/2004 | |
| Comparison of EUS-guided 19-gauge Trucut needle biopsy with EUS-guided fine-needle aspiration | CONCLUSION: The diagnostic accuracy of the new EUS-TNB is comparable to that of EUS-FNA. In our experience, the overall efficacy and safety profile of the Trucut needle appears modest. | 4/22/2004 | |
| Patterns of bleeding after endoscopic sphincterotomy, the subsequent risk of bleeding, and the role of epinephrine injection | CONCLUSIONS: The pattern of bleeding following ES may not predict the risk of late bleeding. Abnormal labs are associated with visible bleeding. Epinephrine injection is safe and appears to provide effective hemostasis. | 3/30/2004 | |
| Is esophagoscopy alone sufficient for patients with reflux symptoms | CONCLUSIONS: Daily abdominal pain and nausea, in combination with a history of ulcer disease, are strong predictors of major gastric or duodenal disease. Patients with reflux without these predictors are highly unlikely to have a major disease involving the stomach or duodenum, and are suitable cand... | 3/5/2004 | |
| Accuracy of EUS in staging of T4 lung cancer | CONCLUSIONS: Caution is warranted when unresectability of lung cancer is based solely on tumor invasion into mediastinal soft tissue at EUS. Overstaging occurs when a tumor appears to invade the pleural layer without mediastinal organ invasion. Confirmation of unresectability by other diagnostic mod... | 3/5/2004 | |
| Suspected sphincter of Oddi dysfunction type II empirical biliary sphincterotomy or manometry-guided therapy | CONCLUSIONS: For patients with suspected biliary SOD type II, empirical biliary sphincterotomy performed by experienced endoscopists appears to be cost-saving in comparison with a strategy based on the results of manometry. | 2/7/2004 |