Journals and Research

Our specialists stay abreast of the most current advances in colorectal care and with their expertise are themselves frequent contributors to leading publications.

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Author(s) Title Description Publish Date
Martin Kaufmann, Natasha Iaboni, Amoon Jamzad, David Hurlbut, Kevin Yi Mi Ren, John F Rudan, Parvin Mousavi, Gabor Fichtinger, Sonal Varma, Antonio Caycedo-Marulanda, Christopher J B Nicol Metabolically Active Zones Involving Fatty Acid Elongation Delineated by DESI-MSI Correlate with Pathological and Prognostic Features of Colorectal Cancer Colorectal cancer (CRC) is the second leading cause of cancer deaths. Despite recent advances, five-year survival rates remain largely unchanged. Desorption electrospray ionization mass spectrometry imaging (DESI) is an emerging nondestructive metabolomics-based method that retains the spatial orien... 4/28/2023
LATAM Collaborative Colorectal Surgery Consortium Postoperative outcomes of right hemicolectomy for cancer in 11 countries of Latin America A multicentre retrospective study CONCLUSION: This is the first study in Latin America to show better postoperative outcomes at a regional scale when surgery for right colon cancer is performed in high-volume centres. Further studies are needed to validate these data and to identify which of the factors can explain the present resul... 2/7/2023
Alexander A Gaidarski Iii, Marco Ferrara The Colorectal Anastomosis A Timeless Challenge Colorectal anastomosis is a sophisticated problem that demands an elaborate discussion and an elegant solution. "Those who forget the past are condemned to repeat it." George Santayana, Life of Reason , 1905. 1/9/2023
Hagen F Kennecke, Chris J O'Callaghan, Jonathan M Loree, Hussein Moloo, Rebecca Auer, Derek J Jonker, Manoj Raval, Reilly Musselman, Grace Ma, Antonio Caycedo-Marulanda, Vlad V Simianu, Sunil Patel, Lacey D Pitre, Ramzi Helewa, Vallerie L Gordon, Katerina Neumann, Halla Nimeiri, Max Sherry, Dongsheng Tu, Carl J Brown Neoadjuvant Chemotherapy, Excision, and Observation for Early Rectal Cancer The Phase II NEO Trial CCTG CO28 Primary End Point Results CONCLUSION: Three months of induction chemotherapy may successfully downstage a significant proportion of patients with early-stage rectal cancer, allowing well-tolerated organ-preserving surgery. 8/18/2022
Nader M Hanna, Erin Williams, Weidong Kong, Adam Fundytus, Christopher M Booth, Sunil V Patel, Antonio Caycedo-Marulanda, Wiley Chung, Sulaiman Nanji, Shaila J Merchant Incidence, Timing, and Outcomes of Venous Thromboembolism in Patients Undergoing Surgery for Esophagogastric Cancer A Population-Based Cohort Study CONCLUSIONS: The highest risk of VTE is within 30 days of surgery with one third of patients diagnosed after discharge from hospital. Longer hospital LOS and receipt of preoperative chemotherapy are associated with increased risk of VTE. VTE is an independent risk factor for inferior survival in pat... 3/13/2022
PelvEx Collaborative Contemporary Management of Locally Advanced and Recurrent Rectal Cancer Views from the PelvEx Collaborative Pelvic exenteration is a complex operation performed for locally advanced and recurrent pelvic cancers. The goal of surgery is to achieve clear margins, therefore identifying adjacent or involved organs, bone, muscle, nerves and/or vascular structures that may need resection. While these extensive r... 3/10/2022
Sunil V Patel, Vanessa Wiseman, Lisa Zhang, P Hugh MacDonald, Shaila M Merchant, Kathleen Wattie Barnett, Antonio Caycedo-Marulanda The impact of robotic surgery on a tertiary care colorectal surgery program, an assessment of costs and short term outcomes A Canadian perspective BACKGROUND: Robotic surgery for colorectal pathology has gained interest as it can overcome technical challenges and limitations of traditional laparoscopic surgery. A lack of training and costs have been cited as reasons for limiting its use in Canada. The objective of this paper was to assess the ... 2/25/2022
Antonio Caycedo-Marulanda, Chris P Verschoor, Carl P Brown, Ahmer Karimuddin, Manoj Raval, Terry Phang, Elena Vikis, George Melich, Sunil V Patel, Canadian taTME Expert COllaboration (CaTaCO) Transanal total mesorectal excision for abdominoperineal resection is associated with poor oncological outcomes in rectal cancer patients A word of caution from a multicentric Canadian cohort study CONCLUSION: Our results demonstrate inferior outcomes in those undergoing taTME-APR compared with taTME-LAR. The use of this technique for this particular indication needs to be carefully considered. 12/27/2021
PelvEx Collaborative Induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as neoadjuvant treatment for locally recurrent rectal cancer study protocol of a multicentre, open-label, parallel-arms, randomized controlled study PelvEx II BACKGROUND: A resection with clear margins (R0 resection) is the most important prognostic factor in patients with locally recurrent rectal cancer (LRRC). However, this is achieved in only 60 per cent of patients. The aim of this study is to investigate whether the addition of induction chemotherapy... 6/5/2021
PelvEx Collaborative Perioperative management and anaesthetic considerations in pelvic exenterations using Delphi methodology results from the PelvEx Collaborative CONCLUSION: The perioperative and anaesthetic management of patients undergoing pelvic exenteration is best accomplished by a dedicated multidisciplinary team with relevant domain expertise in the setting of a specialized tertiary unit. This consensus statement has addressed key domains within the f... 2/20/2021
Antonio Caycedo-Marulanda, Lawrence Lee, Sami A Chadi, Chris P Verschoor, Jordan Crosina, Shady Ashamalla, Carl J Brown, Canadian taTME Expert Collaboration Association of Transanal Total Mesorectal Excision With Local Recurrence of Rectal Cancer CONCLUSIONS AND RELEVANCE: In this cohort study, transanal TME performed by experienced surgeons was associated with an incidence of LR and SR that is in line with the published literature on open and laparoscopic TME, suggesting that transanal TME may be an acceptable approach for management of rec... 2/3/2021
Antonio Caycedo-Marulanda, Kara Nadeau, Chris P Verschoor, Dana Sands, Antonino Spinelli, Shady Ashamalla, Sunil V Patel, Francesca Di Candido, Angela Mujukian, Karen Zaghiyan, Grant Stevenson, Albert Wolthuis, David A Clark, Andre D'Hoore, Andrew Stevenson, Steven D Wexner Exploring the perioperative outcomes of a sample of successful adopters of transanal total mesorectal excision taTME during the learning phase BACKGROUND: Transanal total mesorectal excision can be a technically challenging operation to master. While many early adopters have reported adequate outcomes, others have failed to reproduce these results. There are contradicting data on oncologic outcomes during the learning phase of this techniq... 11/27/2020
Antonio Caycedo-Marulanda, Sunil V Patel, Chris P Verschoor, Johanna P Uscategui, Sami A Chadi, Gabriela Moeslein, Manish Chand, Yasuko Maeda, John R T Monson, Steven D Wexner, Julio Mayol A Snapshot of the International Views of the Treatment of Rectal Cancer Patients, a Multi-regional Survey International Tendencies in Rectal Cancer CONCLUSIONS: The management of rectal cancer varies among different regions. Identification of differences is important when considering global efforts to improve management and interpret data. 10/9/2020
Sami A Chadi, Keegan Guidolin, Antonio Caycedo-Marulanda, Abdu Sharkawy, Antonino Spinelli, Fayez A Quereshy, Allan Okrainec Current Evidence for Minimally Invasive Surgery During the COVID-19 Pandemic and Risk Mitigation Strategies A Narrative Review OBJECTIVE: Our objective was to review the literature surrounding the risks of viral transmission during laparoscopic surgery and propose mitigation measures to address these risks. 7/18/2020
PelvEx Collaborative Predicting outcomes of pelvic exenteration using machine learning CONCLUSION: This paper highlights the potential for predictive modelling of large international databases. Current data allow moderate predictive ability of both complex ANNs and more classic methods. 7/7/2020
S E van Oostendorp, S X Roodbeen, C C Chen, A Caycedo-Marulanda, H M Joshi, P J Tanis, C Cunningham, J B Tuynman, R Hompes Transperineal minimally invasive APE preliminary outcomes in a multicenter cohort CONCLUSIONS: TpAPE seems to be feasible with acceptable perioperative morbidity and a relatively low rate of perineal wound dehiscence, while histopathological outcomes remain suboptimal. Additional evaluation of the viability of this technique is needed in the form of a prospective trial with stand... 6/20/2020
Antonio Caycedo-Marulanda, Sunil Patel, Shaila Merchant, Carl Brown Introduction of new techniques and technologies in surgery Where is transanal total mesorectal excision today The introduction of new surgical techniques and technologies has traditionally been unregulated. In many settings surgeons frequently adopt novel procedures without following a structured program of implementation or supervision. The appearance of innovative technology played a pivotal role in the a... 6/20/2020
Antonio Caycedo-Marulanda, Carl J Brown, Sami A Chadi, Shady Ashamalla, Lawrence Lee, Peter Stotland, Usmaan Hameed, George Melich, Grace Ma, Francois Letarte, Ahmer Karimuddin, Fayez Quereshy, Terry Phang, Manoj Raval, Elena Vikis, A Sender Liberman, Alexandre Bouchard, Phillipe Bouchard, Sebastien Drolet Canadian taTME expert collaboration CaTaCO position statement CONCLUSIONS: Authors agree transanal total mesorectal excision is technically demanding and has a significant risk for morbidity. As of now, there is uncertainty for some of the outcomes. We consider it is possible to safely adopt this operation and obtain adequate results, however for this purpose ... 6/7/2020
Mazen R Al-Mansour, Antonio Caycedo-Marulanda, Brian R Davis, Abdulrahim Alawashez, Salvatore Docimo, Alia Qureshi, Shawn Tsuda SAGES TAVAC safety and efficacy analysis confocal laser endomicroscopy CONCLUSIONS: CLE has an excellent safety profile. CLE can increase the diagnostic accuracy in a number of gastrointestinal pathologies. 5/15/2020
PelvEx Collaborative Simultaneous pelvic exenteration and liver resection for primary rectal cancer with synchronous liver metastases results from the PelvEx Collaborative CONCLUSION: Simultaneous pelvic exenteration and liver resection is feasible, with acceptable morbidity and mortality. Simultaneous resection should only be performed where an R0 resection of both pelvic and hepatic disease is anticipated. 4/16/2020
A Caycedo-Marulanda, C P Verschoor Experience beyond the learning curve of transanal total mesorectal excision taTME and its effect on the incidence of anastomotic leak CONCLUSIONS: Proficiency is likely to have a positive effect on the 30-day occurrence of anastomotic leak. Larger studies are required to explore the impact of experience on local recurrence. 3/1/2020
PelvEx Collaborative Management strategies for patients with advanced rectal cancer and liver metastases using modified Delphi methodology results from the PelvEx Collaborative CONCLUSION: This Delphi process highlights the diverse treatment of advanced rectal cancer with liver metastases and provides recommendations from an experienced international group regarding the multidisciplinary management approach. 2/12/2020
Edward A Dickson, Marta Penna, Chris Cunningham, Fiona M Ratcliffe, Jonathan Chantler, Nicholas A Crabtree, Jurriaan B Tuynman, Matthew R Albert, John R T Monson, Roel Hompes, International TaTME Registry Collaborative Carbon Dioxide Embolism Associated With Transanal Total Mesorectal Excision Surgery A Report From the International Registries CONCLUSIONS: Surgeons undertaking transanal total mesorectal excision must be aware of the possibility of carbon dioxide embolus and its potential risk factors, including venous bleeding (wrong plane surgery), high insufflation pressures, and patient positioning. Prompt recognition and management ca... 6/13/2019
Marco Ferrara, Brian R Kann Urological Injuries during Colorectal Surgery The proximity of the colon and rectum to the organs of the urologic system virtually ensures that iatrogenic urologic injuries become a distinct possibility during complex colorectal surgical procedures. An intimate knowledge of urogenital anatomy as well as strategies for identification and repair ... 5/8/2019
Marius Hoogerboord, James Ellsmere, Antonio Caycedo-Marulanda, Carl Brown, Shiva Jayaraman, David Urbach, Sean Cleary Laparoscopic colectomy trends in implementation in Canada and globally Comparisons with other high-income countries suggest that Canada has been slower to adopt laparoscopic colectomy (LC). The Canadian Association of General Surgeons sought to evaluate the barriers to adoption of laparoscopic colon surgery and to propose potential intervention strategies to enhance th... 3/26/2019
A Caycedo-Marulanda, G Ma, H Y Jiang Transanal total mesorectal excision taTME in a single-surgeon setting refinements of the technique during the learning phase CONCLUSIONS: This study confirms the safety and effectiveness of single-surgeon implementation of taTME technique. Technical challenges experienced in this setting were not obstacles for further refinement and to establish a tendency towards better outcomes. Overcoming technical challenges is possib... 6/30/2018
A Crawford, J Firtell, A Caycedo-Marulanda How Is Rectal Cancer Managed a Survey Exploring Current Practice Patterns in Canada CONCLUSION: The majority of surveyed surgeons use MRI for pelvic staging and discuss rectal cancer cases at multidisciplinary cancer conference. Many are using minimally invasive techniques; however, the use of taTME is not yet widespread. Surgeons currently favor longer intervals from neoadjuvant c... 2/2/2018
Antonio Caycedo-Marulanda, Henry Y Jiang, Erica L Kohtakangas Transanal minimally invasive surgery for benign large rectal polyps and early malignant rectal cancers experience and outcomes from the first Canadian centre to adopt the technique CONCLUSION: To our knowledge, this is the first Canadian study showing TAMIS to be an efficient and safe procedure for the treatment of well-selected patients with rectal lesions. Outcomes from our centre are comparable with those found in the literature. 11/28/2017
Antonio Caycedo-Marulanda, Henry Y Jiang, Erica L Kohtakangas Outcomes of a Single Surgeon-Based Transanal-Total Mesorectal Excision TATME for Rectal Cancer CONCLUSION: TATME performed by a one-surgeon team is oncologically adequate, and it is safe and feasible. Morbidities are comparable with existing literature data from two-surgeon teams. In addition, resection margins, mesorectal integrity, and LN harvests are also comparable or superior to some of ... 7/14/2017
Itzhak Avital, Russell C Langan, Thomas A Summers, Scott R Steele, Scott A Waldman, Vadim Backman, Judy Yee, Aviram Nissan, Patrick Young, Craig Womeldorph, Paul Mancusco, Renee Mueller, Khristian Noto, Warren Grundfest, Anton J Bilchik, Mladjan Protic, Martin Daumer, John Eberhardt, Yan Gao Man, Björn Ldm Brücher, Alexander Stojadinovic Evidence-based Guidelines for Precision Risk Stratification-Based Screening PRSBS for Colorectal Cancer Lessons learned from the US Armed Forces Consensus and Future Directions Colorectal cancer (CRC) is the third most common cause of cancer-related death in the United States (U.S.), with estimates of 143,460 new cases and 51,690 deaths for the year 2012. Numerous organizations have published guidelines for CRC screening; however, these numerical estimates of incidence and... 3/6/2013
Mark R Nehler, Renee J Mueller, Robert B McLafferty, Steven P Johnson, Jeremy D Nussbaum, Mark A Mattos, Thomas A Whitehill, Anne L Esler, Kim J Hodgson, William C Krupski Outcome of catheter-directed thrombolysis for lower extremity arterial bypass occlusion CONCLUSION: Despite relatively high initial technical success for LEAB thrombolysis, eventual failure is the rule rather than the exception. Recurrent LEAB occlusions lead to significant morbidity, including recurrent interventions, eventual graft infection/replacement, and limb loss. However, LEAB ... 1/7/2003