Journals and Research
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| Author(s) | Title | Description | Publish Date |
|---|---|---|---|
| Short-term surgical outcomes of rectal adenocarcinoma surgical treatment in Latin America a multicenter, retrospective assessment in 49 centers from 12 countries | CONCLUSIONS: This study includes information about the approach and results of rectal cancer management in Latin America at a large scale. In the future, this information can be used as a bridge to identify areas of improvement among rectal cancer patients' treatment in the region. | 12/22/2024 | |
| Rectal Cancer Watch-and-Wait Management Experience of 545 Patients From the US Rectal Cancer Research Group | CONCLUSIONS: This multicenter study indicates that the watch-and-wait approach for locally advanced rectal cancer is feasible with acceptable outcomes across a variety of geographical regions and practice settings in the United States. Local regrowth and distant metastasis rates were within publishe... | 11/7/2024 | |
| The role of RObotic surgery in EMergency setting ROEM protocol for a multicentre, observational, prospective international study on the use of robotic platform in emergency surgery | BACKGROUND: Robotic surgery has gained widespread acceptance in elective interventions, yet its role in emergency procedures remains underexplored. While the 2021 WSES position paper discussed limited studies on the application of robotics in emergency general surgery, it recommended strict patient ... | 6/4/2024 | |
| The impact of robotic rectal cancer surgery at a Canadian regional cancer centre a retrospective cohort study | CONCLUSION: Access to robotic rectal cancer surgery increased successful completion of MIS and shortened hospital stay, with a similar total cost of care. Robotic rectal cancer surgery can enhance patient outcomes in the Canadian setting. | 5/1/2024 | |
| Emergency Colorectal Surgery in Those with Cirrhosis A Population-based Study Assessing Practice Patterns, Outcomes and Predictors of Mortality | CONCLUSION: Individuals with cirrhosis who require emergent colorectal surgery have a high risk of postoperative complications, including mortality. Increasing MELD-Na score is associated with mortality and can be used to risk stratify individuals. | 4/10/2024 | |
| A systematic review and meta-analysis of oncological outcomes with transanal total mesorectal excision for rectal cancer | CONCLUSION: Our data suggest that the local recurrence for regular laparoscopic and transanal TME surgeries may be comparable, suggesting that taTME can be performed without influencing locoregional oncological outcomes in patients treated at specialized institutions and who have been cautiously sel... | 4/9/2024 | |
| The empty pelvis syndrome a core data set from the PelvEx collaborative | CONCLUSIONS: EPS is an area of unmet research and clinical need. This study provides an agreed definition and core data set for EPS to facilitate further research. | 3/8/2024 | |
| Beating the empty pelvis syndrome the PelvEx Collaborative core outcome set study protocol | INTRODUCTION: The empty pelvis syndrome is a significant source of morbidity following pelvic exenteration surgery. It remains poorly defined with research in this field being heterogeneous and of low quality. Furthermore, there has been minimal engagement with patient representatives following pelv... | 2/5/2024 | |
| Venous invasion detectable only by elastic stain shows weak prognostic value in colon cancer | CONCLUSIONS: VI detectable only by elastic stains do not show prognostic significance for survival in colon cancer. For pathologists with high baseline VI detections rates on routine stain, reflexive use of elastic stain may be of limited value. | 1/22/2024 | |
| Effect of low-level creatinine clearance on short-term postoperative complications in patients with colorectal cancer | CONCLUSIONS: Preoperative low-level CrCl, multi-organ combined resection, and CCI were significant risk factors of postoperative complications in CRC patients. Preoperative low-level CrCl and multi-organ combined resection has a poor prognostic impact for elderly patients with CRC. These findings sh... | 1/10/2024 | |
| Metabolically Active Zones Involving Fatty Acid Elongation Delineated by DESI-MSI Correlate with Pathological and Prognostic Features of Colorectal Cancer | Colorectal cancer (CRC) is the second leading cause of cancer deaths. Despite recent advances, five-year survival rates remain largely unchanged. Desorption electrospray ionization mass spectrometry imaging (DESI) is an emerging nondestructive metabolomics-based method that retains the spatial orien... | 4/28/2023 | |
| Postoperative outcomes of right hemicolectomy for cancer in 11 countries of Latin America A multicentre retrospective study | CONCLUSION: This is the first study in Latin America to show better postoperative outcomes at a regional scale when surgery for right colon cancer is performed in high-volume centres. Further studies are needed to validate these data and to identify which of the factors can explain the present resul... | 2/7/2023 | |
| The Colorectal Anastomosis A Timeless Challenge | Colorectal anastomosis is a sophisticated problem that demands an elaborate discussion and an elegant solution. "Those who forget the past are condemned to repeat it." George Santayana, Life of Reason , 1905. | 1/9/2023 | |
| Neoadjuvant Chemotherapy, Excision, and Observation for Early Rectal Cancer The Phase II NEO Trial CCTG CO28 Primary End Point Results | CONCLUSION: Three months of induction chemotherapy may successfully downstage a significant proportion of patients with early-stage rectal cancer, allowing well-tolerated organ-preserving surgery. | 8/18/2022 | |
| Incidence, Timing, and Outcomes of Venous Thromboembolism in Patients Undergoing Surgery for Esophagogastric Cancer A Population-Based Cohort Study | CONCLUSIONS: The highest risk of VTE is within 30 days of surgery with one third of patients diagnosed after discharge from hospital. Longer hospital LOS and receipt of preoperative chemotherapy are associated with increased risk of VTE. VTE is an independent risk factor for inferior survival in pat... | 3/13/2022 | |
| Contemporary Management of Locally Advanced and Recurrent Rectal Cancer Views from the PelvEx Collaborative | Pelvic exenteration is a complex operation performed for locally advanced and recurrent pelvic cancers. The goal of surgery is to achieve clear margins, therefore identifying adjacent or involved organs, bone, muscle, nerves and/or vascular structures that may need resection. While these extensive r... | 3/10/2022 | |
| The impact of robotic surgery on a tertiary care colorectal surgery program, an assessment of costs and short term outcomes A Canadian perspective | BACKGROUND: Robotic surgery for colorectal pathology has gained interest as it can overcome technical challenges and limitations of traditional laparoscopic surgery. A lack of training and costs have been cited as reasons for limiting its use in Canada. The objective of this paper was to assess the ... | 2/25/2022 | |
| Transanal total mesorectal excision for abdominoperineal resection is associated with poor oncological outcomes in rectal cancer patients A word of caution from a multicentric Canadian cohort study | CONCLUSION: Our results demonstrate inferior outcomes in those undergoing taTME-APR compared with taTME-LAR. The use of this technique for this particular indication needs to be carefully considered. | 12/27/2021 | |
| Induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as neoadjuvant treatment for locally recurrent rectal cancer study protocol of a multicentre, open-label, parallel-arms, randomized controlled study PelvEx II | BACKGROUND: A resection with clear margins (R0 resection) is the most important prognostic factor in patients with locally recurrent rectal cancer (LRRC). However, this is achieved in only 60 per cent of patients. The aim of this study is to investigate whether the addition of induction chemotherapy... | 6/5/2021 | |
| Perioperative management and anaesthetic considerations in pelvic exenterations using Delphi methodology results from the PelvEx Collaborative | CONCLUSION: The perioperative and anaesthetic management of patients undergoing pelvic exenteration is best accomplished by a dedicated multidisciplinary team with relevant domain expertise in the setting of a specialized tertiary unit. This consensus statement has addressed key domains within the f... | 2/20/2021 | |
| Association of Transanal Total Mesorectal Excision With Local Recurrence of Rectal Cancer | CONCLUSIONS AND RELEVANCE: In this cohort study, transanal TME performed by experienced surgeons was associated with an incidence of LR and SR that is in line with the published literature on open and laparoscopic TME, suggesting that transanal TME may be an acceptable approach for management of rec... | 2/3/2021 | |
| Exploring the perioperative outcomes of a sample of successful adopters of transanal total mesorectal excision taTME during the learning phase | BACKGROUND: Transanal total mesorectal excision can be a technically challenging operation to master. While many early adopters have reported adequate outcomes, others have failed to reproduce these results. There are contradicting data on oncologic outcomes during the learning phase of this techniq... | 11/27/2020 | |
| A Snapshot of the International Views of the Treatment of Rectal Cancer Patients, a Multi-regional Survey International Tendencies in Rectal Cancer | CONCLUSIONS: The management of rectal cancer varies among different regions. Identification of differences is important when considering global efforts to improve management and interpret data. | 10/9/2020 | |
| Current Evidence for Minimally Invasive Surgery During the COVID-19 Pandemic and Risk Mitigation Strategies A Narrative Review | OBJECTIVE: Our objective was to review the literature surrounding the risks of viral transmission during laparoscopic surgery and propose mitigation measures to address these risks. | 7/18/2020 | |
| Predicting outcomes of pelvic exenteration using machine learning | CONCLUSION: This paper highlights the potential for predictive modelling of large international databases. Current data allow moderate predictive ability of both complex ANNs and more classic methods. | 7/7/2020 | |
| Transperineal minimally invasive APE preliminary outcomes in a multicenter cohort | CONCLUSIONS: TpAPE seems to be feasible with acceptable perioperative morbidity and a relatively low rate of perineal wound dehiscence, while histopathological outcomes remain suboptimal. Additional evaluation of the viability of this technique is needed in the form of a prospective trial with stand... | 6/20/2020 | |
| Introduction of new techniques and technologies in surgery Where is transanal total mesorectal excision today | The introduction of new surgical techniques and technologies has traditionally been unregulated. In many settings surgeons frequently adopt novel procedures without following a structured program of implementation or supervision. The appearance of innovative technology played a pivotal role in the a... | 6/20/2020 | |
| Canadian taTME expert collaboration CaTaCO position statement | CONCLUSIONS: Authors agree transanal total mesorectal excision is technically demanding and has a significant risk for morbidity. As of now, there is uncertainty for some of the outcomes. We consider it is possible to safely adopt this operation and obtain adequate results, however for this purpose ... | 6/7/2020 | |
| SAGES TAVAC safety and efficacy analysis confocal laser endomicroscopy | CONCLUSIONS: CLE has an excellent safety profile. CLE can increase the diagnostic accuracy in a number of gastrointestinal pathologies. | 5/15/2020 | |
| Simultaneous pelvic exenteration and liver resection for primary rectal cancer with synchronous liver metastases results from the PelvEx Collaborative | CONCLUSION: Simultaneous pelvic exenteration and liver resection is feasible, with acceptable morbidity and mortality. Simultaneous resection should only be performed where an R0 resection of both pelvic and hepatic disease is anticipated. | 4/16/2020 | |
| Experience beyond the learning curve of transanal total mesorectal excision taTME and its effect on the incidence of anastomotic leak | CONCLUSIONS: Proficiency is likely to have a positive effect on the 30-day occurrence of anastomotic leak. Larger studies are required to explore the impact of experience on local recurrence. | 3/1/2020 | |
| Management strategies for patients with advanced rectal cancer and liver metastases using modified Delphi methodology results from the PelvEx Collaborative | CONCLUSION: This Delphi process highlights the diverse treatment of advanced rectal cancer with liver metastases and provides recommendations from an experienced international group regarding the multidisciplinary management approach. | 2/12/2020 | |
| Carbon Dioxide Embolism Associated With Transanal Total Mesorectal Excision Surgery A Report From the International Registries | CONCLUSIONS: Surgeons undertaking transanal total mesorectal excision must be aware of the possibility of carbon dioxide embolus and its potential risk factors, including venous bleeding (wrong plane surgery), high insufflation pressures, and patient positioning. Prompt recognition and management ca... | 6/13/2019 | |
| Urological Injuries during Colorectal Surgery | The proximity of the colon and rectum to the organs of the urologic system virtually ensures that iatrogenic urologic injuries become a distinct possibility during complex colorectal surgical procedures. An intimate knowledge of urogenital anatomy as well as strategies for identification and repair ... | 5/8/2019 | |
| Laparoscopic colectomy trends in implementation in Canada and globally | Comparisons with other high-income countries suggest that Canada has been slower to adopt laparoscopic colectomy (LC). The Canadian Association of General Surgeons sought to evaluate the barriers to adoption of laparoscopic colon surgery and to propose potential intervention strategies to enhance th... | 3/26/2019 | |
| Transanal total mesorectal excision taTME in a single-surgeon setting refinements of the technique during the learning phase | CONCLUSIONS: This study confirms the safety and effectiveness of single-surgeon implementation of taTME technique. Technical challenges experienced in this setting were not obstacles for further refinement and to establish a tendency towards better outcomes. Overcoming technical challenges is possib... | 6/30/2018 | |
| How Is Rectal Cancer Managed a Survey Exploring Current Practice Patterns in Canada | CONCLUSION: The majority of surveyed surgeons use MRI for pelvic staging and discuss rectal cancer cases at multidisciplinary cancer conference. Many are using minimally invasive techniques; however, the use of taTME is not yet widespread. Surgeons currently favor longer intervals from neoadjuvant c... | 2/2/2018 | |
| Transanal minimally invasive surgery for benign large rectal polyps and early malignant rectal cancers experience and outcomes from the first Canadian centre to adopt the technique | CONCLUSION: To our knowledge, this is the first Canadian study showing TAMIS to be an efficient and safe procedure for the treatment of well-selected patients with rectal lesions. Outcomes from our centre are comparable with those found in the literature. | 11/28/2017 | |
| Outcomes of a Single Surgeon-Based Transanal-Total Mesorectal Excision TATME for Rectal Cancer | CONCLUSION: TATME performed by a one-surgeon team is oncologically adequate, and it is safe and feasible. Morbidities are comparable with existing literature data from two-surgeon teams. In addition, resection margins, mesorectal integrity, and LN harvests are also comparable or superior to some of ... | 7/14/2017 | |
| Evidence-based Guidelines for Precision Risk Stratification-Based Screening PRSBS for Colorectal Cancer Lessons learned from the US Armed Forces Consensus and Future Directions | Colorectal cancer (CRC) is the third most common cause of cancer-related death in the United States (U.S.), with estimates of 143,460 new cases and 51,690 deaths for the year 2012. Numerous organizations have published guidelines for CRC screening; however, these numerical estimates of incidence and... | 3/6/2013 | |
| Outcome of catheter-directed thrombolysis for lower extremity arterial bypass occlusion | CONCLUSION: Despite relatively high initial technical success for LEAB thrombolysis, eventual failure is the rule rather than the exception. Recurrent LEAB occlusions lead to significant morbidity, including recurrent interventions, eventual graft infection/replacement, and limb loss. However, LEAB ... | 1/7/2003 |
