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Author(s) Title Description Publish Date
Gnana Deepthi Medarametla, Ripudaman Singh Kahlon, Lampimukhi Mahitha, Sanobar Shariff, Naga Praneeth Vakkalagadda, Hitesh Chopra, Mohammad Amjad Kamal, Neil Patel, Yashendra Sethi, Nirja Kaka Cardiac amyloidosis evolving pathogenesis, multimodal diagnostics, and principles of treatment Amyloidosis is a protein deposition disorder in which insoluble fibril structures accumulate in the bodily tissues damaging the organ function. Cardiac amyloidosis is a severe but under-reported medical condition characterized by the accumulation of amyloid in the extracellular area of the myocardiu... 9/18/2023
Devarsh N Shah, Harshal Prakash Chorya, N Nishitha Ramesh, Sulochana Gnanasekaram, Neil Patel, Yashendra Sethi, Nirja Kaka Myopathies of endocrine origin A review for physicians Myopathies are a common manifestation of endocrine disorders. Endocrine myopathies are often overlooked while considering differential diagnoses in patients with musculoskeletal symptoms. The hindrance to mobility and the musculoskeletal discomfort owing to these myopathies are important causes of d... 9/17/2023
Nuzhat Zahin, Debabrata Roy, Richa Sinha, Sonam Maheshwari, Yashendra Sethi, Neil Patel Epidemiological Correlates of Substance Abuse Among In-Facility Clients of De-addiction and Rehabilitation Centres of District Dehradun A Cross-Sectional Study Background The increasing production, distribution, promotion, and availability of substances contemporaneous with the changing values of society have resulted in rising substance abuse as an emerging public health concern in India. A prevalence of 32-37% has been reported for substance abuse in var... 9/4/2023
Haroutiun Hamzoian, Brittany Harris, Mekdes Ditamo, Shuchi Chaudhary Peculiar Neurological Examination Secondary to Persistent Primitive Hypoglossal Artery A persistent primitive hypoglossal artery (PPHA) is an anatomical variant resulting in persistent carotid-vertebrobasilar anastomoses. This variant arises from the distal cervical segment of the internal carotid artery (ICA) between C1 and C3 and passes through an enlarged hypoglossal canal to join ... 8/23/2023
Neil Patel, Daniel Coban, Stuart Changoor, Kumar Sinha, Ki Soo Hwang, Arash Emami The 5-Factor Modified Frailty Index is Associated With Increased Risk of Reoperations and Adjacent Level Disease Following Single-Level Transforaminal Lumbar Interbody Fusion CONCLUSION: High levels of frailty were predictive of related readmissions, reoperations, any complications, and ASD in older adult patients undergoing single-level TLIF. 8/19/2023
Evan L Tooker, Richard H Wiggins, Mana Espahbodi, Anne Naumer, Luke O Buchmann, Samantha E Greenberg, Neil S Patel The Natural History of Observed SDHx -Related Head and Neck Paragangliomas Using Three-Dimensional Volumetric Tumor Analysis CONCLUSIONS: Over intermediate-term follow-up, observation of treatment-naive SDHx -related HNPGLs did not result in new cranial neuropathy. Although indefinite observation is only appropriate for select cases, these data support an interval of observation to characterize growth rate in asymptomatic... 8/17/2023
Qamar Sultana, Jill Kar, Amogh Verma, Shreya Sanghvi, Nirja Kaka, Neil Patel, Yashendra Sethi, Hitesh Chopra, Mohammad Amjad Kamal, Nigel H Greig A Comprehensive Review on Neuroendocrine Neoplasms Presentation, Pathophysiology and Management Neuroendocrine neoplasms (NENs) are a group of heterogeneous tumors with neuroendocrine differentiation that can arise from any organ. They account for 2% of all malignancies in the United States. A significant proportion of NEN patients experience endocrine imbalances consequent to increased amine ... 8/12/2023
Neil Patel, Nirja Kaka, Pradeep Sharma, Neha Mahajan, Rehnuma Ansari, Yashendra Sethi Good outcome of surgical treatment for contaminated penile wound due to a fall from stairs a case report CONCLUSIONS: Penile trauma is severely under-reported due to the stigma associated with it. Early diagnosis and prompt management are imperative to limit complications. A detailed history helps to evaluate the exact cause and check out possibilities of sexual assault. Appropriate management in tande... 7/26/2023
James W Kearney, Megan N Sax van der Weyden, Nelson Cortes, Orlando Fernandes, Joel R Martin Effect of the Law Enforcement Duty Belt on Muscle Activation during Hip Hinging Movements in Young, Healthy Adults Sixty percent of all law enforcement officers (LEOs) experience low back pain (LBP), with the LEO duty belt (LEO(DB)) commonly reported to be a contributing factor. The primary purpose of the study was to investigate the LEODB's effect on muscular activity and compare it to a tactical vest, which is... 7/25/2023
Soheila Ali Akbari Ghavimi, Matthew R Aronson, Daniel D Ghaderi, Ryan M Friedman, Neil Patel, Terri Giordano, Ryan C Borek, Conor M Devine, Lin Han, Ian N Jacobs, Riccardo Gottardi Modulated Fibrosis and Mechanosensing of Fibroblasts by SB525334 in Pediatric Subglottic Stenosis CONCLUSION: We demonstrate that distinct fibroblast phenotypes from diseased and healthy regions of pediatric SGS patients respond differently to TGF-β1 stimulation, and SB525334 has the superior potential for subglottic stenosis treatment by simultaneously modulating TGF-β and Hippo signaling pathw... 7/17/2023
Megan N Sax van der Weyden, James W Kearney, Nelson Cortes, Orlando Fernandes, Joel R Martin Common law enforcement load carriage systems have limited acute effects on postural stability and muscle activity Law enforcement officers are inherently at a high risk of injury and the loads they must carry during their occupational duties further increase their injury risk. It is unknown how different methods of carrying a law enforcement officer's load influence factors related to injury risk. This study as... 7/12/2023
Jacqueline E Harris, Neil N Patel, Katherine Wai, Kristina W Rosbe Management of Pediatric Persistent Asymptomatic Cervical Lymphadenopathy CONCLUSION: The majority of pediatric PACL is benign and does not require an excisional biopsy to rule out lymphoma. Serial clinical follow-up with neck ultrasound can be used to safely monitor patients. 7/7/2023
Judith Leyens, Lukas Schroeder, Annegret Geipel, Christoph Berg, Bartolomeo Bo, Lotte Lemloh, Neil Patel, Andreas Mueller, Florian Kipfmueller Dynamics of pulmonary hypertension severity in the first 48h in neonates with prenatally diagnosed congenital diaphragmatic hernia INTRODUCTION: Pulmonary hypertension (PH) is one of the major contributing factors to the high morbidity and mortality in neonates with congenital diaphragmatic hernia (CDH). The severity and duration of postnatal PH are an established risk factor for patient outcome; however, the early postnatal dy... 6/21/2023
Taylor C Standiford, Neil N Patel, Amritpal Singh, Grant Gochman, Tara Jamie Wu, Adil I Daud, Andrew N Goldberg Pembrolizumab-associated chronic rhinosinusitis A new endotype and management considerations Patients treated with pembrolizumab experience an increase in paranasal sinus inflammation Use of topical triamcinolone in carboxymethylcellulose is a treatment option for such patients. 6/15/2023
Shantanu Solanki, Khwaja Fahad Haq, George Jolly, Raja Chandra Chakinala, Muhammad Ali Khan, Neil R Patel, Abhishek Bhurwal, Khwaja Saad Haq, Christopher Nabors, Sarju Ganatra, Wilbert Aronow Gastrointestinal haemorrhage in extracorporeal membrane oxygenation insights from the national inpatient sample CONCLUSIONS: Gastrointestinal haemorrhage during ECMO hospitalisations occurred in small but significantly increasing proportions. The inpatient mortality rate and costs associated with GIH were substantial and increased significantly during the study period. 6/14/2023
Taku Wakabayashi, Neil Patel, Matthew Bough, Ankur Nahar, Young Sheng, Bita Momenaei, Mirataollah Salabati, Raziyeh Mahmoudzadeh, Ajay E Kuriyan, Marc J Spirn, Allen Chiang, Jason Hsu, Mitchell S Fineman, Carl D Regillo, Arunan Sivalingam, Allen C Ho, Omesh P Gupta, Yoshihiro Yonekawa VITRECTOMY FOR VITREOUS HEMORRHAGE ASSOCIATED WITH RETINAL VEIN OCCLUSION Visual Outcomes, Prognostic Factors, and Sequelae CONCLUSION: Pars plana vitrectomy is effective for VH associated with retinal vein occlusion, regardless of the duration of hemorrhage. However, pre-existing risk factors and postoperative sequelae may limit visual recovery. 6/9/2023
Vikram Shivkumar, Dipali Nemade, Neelu Dhingra Persistent hiccups following thalamic hemorrhage A case report Persistent hiccups (lasting more than 48 hours) can cause physical and emotional distress. They can result in dehydration, exhaustion, malnutrition, insomnia, wound dehiscence, ventilatory desynchronization, and hemodynamic changes. Hiccups are thought to be due to a complex reflex arc involving per... 6/5/2023
Victoria Peterson, Vasileios Kokkinos, Enzo Ferrante, Ashley Walton, Timon Merk, Amir Hadanny, Varun Saravanan, Nathaniel Sisterson, Naoir Zaher, Alexandra Urban, R Mark Richardson Deep net detection and onset prediction of electrographic seizure patterns in responsive neurostimulation OBJECTIVE: Managing the progress of drug-resistant epilepsy patients implanted with the Responsive Neurostimulation (RNS) System requires the manual evaluation of hundreds of hours of intracranial recordings. The generation of these large amounts of data and the scarcity of experts' time for evaluat... 5/27/2023
Manas Dave, Neil Patel Artificial intelligence in healthcare and education Artificial intelligence (AI) is rapidly transforming the healthcare and medical and dental education sectors. With advancements in AI technology and its integration into routine tasks, the field of healthcare and education is rapidly evolving. This article aims to provide an in-depth analysis of the... 5/26/2023
Arash Emami, Neil Patel, Daniel Coban, Stephen Saela, Kumar Sinha, Michael Faloon, Ki Soo Hwang Comparing clinical and radiological outcomes between single-level OLIF and XLIF A systematic review and meta-analysis CONCLUSIONS: This meta-analysis demonstrates similar clinical and radiological outcomes between single-level OLIF and XLIF from L1 to L5. XLIF had significantly higher rates of neuropraxia, whereas OLIF had greater rates of vascular injury. 5/26/2023
Kareem El Naamani, Panagiotis Mastorakos, Nimer Adeeb, Mathews Lan, James Castiglione, Omaditya Khanna, Jose Danilo Bengzon Diestro, Rachel M McLellan, Mahmoud Dibas, Justin E Vranic, Assala Aslan, Hugo H Cuellar-Saenz, Adrien Guenego, Joseph Carnevale, Guillaume Saliou, Christian Ulfert, Markus Möhlenbruch, Paul M Foreman, Jay A Vachhani, Muhammad U Hafeez, Muhammad Waqas, Vincent M Tutino, James D Rabinov, Yifan Ren, Caterina Michelozzi, Julian Spears, Pietro Panni, Christoph J Griessenauer, Hamed Asadi, Robert W Regenhardt, Christopher J Stapleton, Sherief Ghozy, Adnan Siddiqui, Nirav J Patel, Peter Kan, Srikanth Boddu, Jared Knopman, Mohammad A Aziz-Sultan, Mario Zanaty, Ritam Ghosh, Rawad Abbas, Abdelaziz Amllay, Stavropoula I Tjoumakaris, Michael R Gooch, Nicole M Cancelliere, Nabeel A Herial, Robert H Rosenwasser, Hekmat Zarzour, Richard F Schmidt, Vitor Mendes Pereira, Aman B Patel, Pascal Jabbour, Adam A Dmytriw, WorldWideWEB Consortium Long-Term Follow-Up of Cerebral Aneurysms Completely Occluded at 6 Months After Intervention with the Woven EndoBridge WEB Device a Retrospective Multicenter Observational Study The Woven EndoBridge (WEB) device has been widely used to treat intracranial wide neck bifurcation aneurysms. Initial studies have demonstrated that approximately 90% of patients have same or improved long-term aneurysm occlusion after the initial 6-month follow up. The aim of this study is to asses... 5/10/2023
Basem Zaino, Rashika Goel, Sanjana Devaragudi, Ananya Prakash, Yogeshkumar Vaghamashi, Yashendra Sethi, Neil Patel, Nirja Kaka Diabetic neuropathy Pathogenesis and evolving principles of management The global rise of prediabetes and diabetes has spawned an epidemic of complications associated with these conditions. Neuropathy is the most common consequence, with distal symmetric polyneuropathy (DSP) being the most prevalent. Diabetic neuropathy (DN) is a debilitating consequence of diabetes me... 5/10/2023
Tiffany T Pham, Andrew E Heidari, Ellen M Hong, Earl Steward, Yueqiao Qu, Lily Y Chen, Brandyn S Dunn, Soo Hong Seo, Adeela Syed, Katelyn Dilley, Lauren Lee, Dana M Hutchison, Kyle D Hansen, Urja Patel, Sehwan Kim, Michael G Hill, Brian J F Wong Electrochemical Lipolysis Induces Adipocyte Death and Fat Necrosis In Vivo Pilot Study in Pigs CONCLUSIONS: In vivo ECLL induces fat necrosis in pigs. Further studies are needed to evaluate volumetric fat reduction.Clinical Relevance Statement In vivo electrochemical lipolysis (ECLL) induces adipocyte death and fat necrosis. ELL has the potential to be utilize in body fat contouring. 5/10/2023
Juan Gonzalez, Neil Patel, Raymond L Ownby Cognitive function and impact on driving after SARS-COV-2 infection in a man with long-standing HIV infection a case report A substantial number of individuals who experience COVID-19 infection experience prolonged physical and mental symptoms after resolution of their initial infection, and among them, many individuals experience cognitive difficulties including memory lapses and executive function difficulties, often r... 5/9/2023
Jessica M Veatch, Joel R Narveson, Ryan W Walters, Neil D Patel, Viren P Punja, Carlos A Fernandez, Kaily L Ewing, John A Aucar, Eric J Kuncir The Relationship Between an Individuals Birthday and Admission for Traumatic Injury BACKGROUND: Birthdays provide an opportunity to celebrate; however, they can also be associated with various adverse medical events. This is the first study to examine the association between birthdays and in-hospital trauma team evaluation. 5/6/2023
Viren Punja, Thomas Capasso, Laura Stokes, Kelley Ray, Joel R Narveson, Ryan W Walters, Carlos Fernandez, Neil D Patel, Kaily Ewing, Eric Kuncir The Impact of Relocating a Trauma Center Retrospective Observations on Payer Demographics and Cost-Analysis BACKGROUND: Standardization of trauma centers improves quality of care, yet that comes with financial challenges. The decision to designate a trauma center typically focuses on access, quality of care, and the needs of the local community, but less often considers the financial viability of the trau... 5/4/2023
Deborah D Chin, Neil Patel, Woori Lee, Sonali Kanaya, Jackson Cook, Eun Ji Chung Long-term, in vivo therapeutic effects of a single dose of miR-145 micelles for atherosclerosis Atherosclerosis is a chronic inflammatory disease that is characterized by the build-up of lipid-rich plaques in the arterial walls. The standard treatment for patients with atherosclerosis is statin therapy aimed to lower serum lipid levels. Despite its widespread use, many patients taking statins ... 5/1/2023
Adam B Fink, Charmaine Ong, Moez K Sumar, Neil C Patel, Nebojsa Nick Knezevic The Discrepancy and Agreement between Patient-Reported Percentage Pain Reduction and Calculated Percentage Pain Reduction in Chronic Pain Patients Two derivatives of the numeric rating scale (NRS) and visual analog scale (VAS), namely patient-reported percentage pain reduction (PRPPR) and calculated percentage pain reduction (CPPR), are commonly used when evaluating pain reduction. A small number of studies have attempted to assess the agreeme... 4/24/2023
Yashendra Sethi, Nirja Kaka, Neil Patel, Debabrata Roy, Hitesh Chopra, Talha Bin Emran Environmental correlates of infectious diseases in South-East Asia A perspective on the missed link •Climate change, essentially due to global warming, the plundering of the earth's ecosystem.•Changing climatic circumstances may affect species' range and density.•Infectious disease can be seen as an outcome derived from multi-factorial correlates.•"One health" needs more attention, specially in re... 4/24/2023
Raymond L Ownby, Drenna Waldrop, Rosemary Davenport, Michael Simonson, Joshua Caballero, Kamila Thomas-Purcell, Donrie Purcell, Victoria Ayala, Juan Gonzalez, Neil Patel, Kofi Kondwani A mobile app for chronic disease self-management for individuals with low health literacy A multisite randomized controlled clinical trial CONCLUSIONS: The mobile app was effective in increasing participants’ levels of several psychosocial variables, but reading difficulty level was not significantly related to outcomes. Registered at NCT02922439 . 4/17/2023
Amrita Basu, Rachel N Champagne, Neil G Patel, Elijah D Nicholson, Ryan J Weiss TFCP2 is a transcriptional regulator of heparan sulfate assembly and melanoma cell growth Heparan sulfate (HS) is a long, linear polysaccharide that is ubiquitously expressed in all animal cells and plays a key role in many cellular processes, including cell signaling and development. Dysregulation of HS assembly has been implicated in pathophysiological conditions, such as tumorigenesis... 4/15/2023
Yashendra Sethi, Arun Umesh Mahtani, Nimrat Khehra, Inderbir Padda, Neil Patel, Sneha Annie Sebastian, Gurnaaz Malhi, Oroshay Kaiwan, Sunil Saith, Gurpreet Johal Gene Editing as the Future of Cardiac Amyloidosis Therapeutics Cardiac Amyloidosis (CA) is a manifestation of a systemic disorder resulting from the deposition of transthyretin (TTR) in the myocardium. This leads to a myriad of manifestations ranging from conduction defects to heart failure. Previously CA was considered a rare disease, but recent advances in di... 4/14/2023
Flaminia Pugnaloni, Irma Capolupo, Neil Patel, Paola Giliberti, Andrea Dotta, Pietro Bagolan, Florian Kipfmueller Role of microRNAs in Congenital Diaphragmatic Hernia-Associated Pulmonary Hypertension Epigenetic regulators such as microRNAs (miRNAs) have a key role in modulating several gene expression pathways and have a role both in lung development and function. One of the main pathogenetic determinants in patients with congenital diaphragmatic hernia (CDH) is pulmonary hypertension (PH), whic... 4/13/2023
Neil N Patel, Arushi Gulati, Aaron Lee Zebolsky, Andrea M Park, Rahul Seth, P Daniel Knott Through a New Lens Skin-Grafted Free Flaps and Objective Facial Skin Color Matching Background: Head and neck ablative surgery can impose aesthetic disfigurement, particularly when severe color mismatch exists between native and reconstructed facial skin. To date, the accuracy, objectivity, and modifiability of facial skin color matching remains poorly understood. Objective: To mea... 4/10/2023
Allison R Durham, Evan L Tooker, Neil S Patel, Richard K Gurgel Epidemiology and Risk Factors for Development of Sporadic Vestibular Schwannoma Vestibular schwannomas (VSs) are benign, slow-growing tumors of the eighth cranial nerve. Sporadic unilateral VSs constitute approximately 95% of all newly diagnosed tumors. There is little known about risk factors for developing sporadic unilateral VS. Potential risk factors that have been reported... 4/5/2023
Sharada H Gowda, Neil Patel Heart of the Matter Cardiac Dysfunction in Congenital Diaphragmatic Hernia Despite advances in caring for neonates with congenital diaphragmatic hernia (CDH), mortality and morbidity continues to be high. Additionally, the pathophysiology of cardiac dysfunction in this condition is poorly understood. Postnatal cardiac dysfunction in neonates with CDH may be multifactorial ... 4/3/2023
Mihaela Simona Popoviciu, Nirja Kaka, Yashendra Sethi, Neil Patel, Hitesh Chopra, Simona Cavalu Type 1 Diabetes Mellitus and Autoimmune Diseases A Critical Review of the Association and the Application of Personalized Medicine Type 1 Diabetes Mellitus (T1DM) is a common hyperglycemic disease characterized by the autoimmune destruction of insulin-producing beta cells of the pancreas. Various attempts have been made to understand the complex interplay of genetic and environmental factors which lead to the development of the... 3/29/2023
Robert J Macielak, Anne Morgan Selleck, Armine Kocharyan, Jacob B Hunter, Ankita Patro, Elizabeth L Perkins, Christopher A Hamilton, Neil S Patel, Richard K Gurgel, Alex D Sweeney, Kevin D Brown, Michael J Link, Matthew L Carlson Approach to Cochlear Implantation in Patients With Ventriculoperitoneal Shunts CONCLUSION: CI can be performed at low risk, either contralateral or ipsilateral, to a VP shunt, and does not mandate shunt revision in most cases. Additional considerations regarding CI receiver-stimulator placement are necessary with programmable shunts to mitigate device interaction. Preoperative... 3/20/2023
Bartolomeo Bo, Flaminia Pugnaloni, Amelia Licari, Neil Patel, Brigitte Strizek, Lotte Lemloh, Judith Leyens, Andreas Mueller, Florian Kipfmueller Ductus arteriosus flow predicts outcome in neonates with congenital diaphragmatic hernia CONCLUSIONS: A VTI ratio <1.0 is a valuable threshold to identify high-risk CDH neonates. For improved risk stratification, other parameters-for example, left ventricular cardiac dysfunction-should be combined with DA flow assessment. 3/15/2023
Dalbir Kaur, Rajnikant L Mehta, Hugh Jarrett, Sue Jowett, Nicola K Gale, Alice M Turner, Monica Spiteri, Neil Patel Phase III, two arm, multi-centre, open label, parallel-group randomised designed clinical investigation of the use of a personalised early warning decision support system to predict and prevent acute exacerbations of chronic obstructive pulmonary disease Predict amp; Prevent AECOPD - study protocol INTRODUCTION: With 65 million cases globally, chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death and imposes a heavy burden on patients' lives and healthcare resources worldwide. Around half of all patients with COPD have frequent (≥2 per year) acute exacerbations of C... 3/13/2023
Yashendra Sethi, Neil Patel, Nirja Kaka, Oroshay Kaiwan, Jill Kar, Arsalan Moinuddin, Ashish Goel, Hitesh Chopra, Simona Cavalu Precision Medicine and the future of Cardiovascular Diseases A Clinically Oriented Comprehensive Review Cardiac diseases form the lion's share of the global disease burden, owing to the paradigm shift to non-infectious diseases from infectious ones. The prevalence of CVDs has nearly doubled, increasing from 271 million in 1990 to 523 million in 2019. Additionally, the global trend for the years lived ... 3/11/2023
Neil Patel, Varun K Dalmia, Matthew Carnevale, Evan Lipsitz, Jeffrey Indes Identification and characterization of new candidates for abdominal aortic aneurysm screening in patients outside of current accepted guidelines CONCLUSIONS: Our analysis suggests male ever-smokers aged 45 to 65, male never-smokers aged 65 to 75, male never-smokers aged greater than 75, and female ever-smokers aged 65 or greater have a more than 1% prevalence of AAA and, therefore, may benefit from screening. Outcomes were significantly wors... 3/9/2023
Prathamesh Gawde, Harsh Shah, Harsh Patel, Koppineedi S Bharathi, Neil Patel, Yashendra Sethi, Nirja Kaka Revisiting Migraine The Evolving Pathophysiology and the Expanding Management Armamentarium Migraine affects about one billion people worldwide yearly and is one of the most common neurologic illnesses, with a high prevalence and morbidity, particularly among young adults and females. Migraine is associated with many comorbidities, including stress, sleep difficulties, and suicidal ideatio... 3/7/2023
Patrick Daragh Chakravarty, Fiona Sim, Mohd Afiq Mohd Slim, Neil Patel, David M Wynne, William Andrew Clement Congenital nasal pyriform aperture stenosis; our experience of 34 cases CONCLUSION: These results suggest that a pyriform aperture of less than 6 mm requires surgical intervention. Associated birth anomalies add additional management considerations but in this cohort were not associated with increased need for surgery. A potential association between CNPAS and low socio... 3/4/2023
Neil J Patel, Anisa Ashraf, Eun Ji Chung Extracellular Vesicles as Regulators of the Extracellular Matrix Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EV... 2/25/2023
Neil V Shah, Marine Coste, Adam J Wolfert, Samuel Gedailovich, Brian Ford, David J Kim, Nathan S Kim, Chibuokem P Ikwuazom, Neil Patel, Amanda M Dave, Peter G Passias, Frank J Schwab, Virginie Lafage, Carl B Paulino, Bassel G Diebo The Impact of Prematurity at Birth on Short-Term Postoperative Outcomes Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Prematurity is associated with surgical complications. This study sought to determine the risk of prematurity on 30-day complications, reoperations, and readmissions following ≥7-level PSF for AIS which has not been established. Utilizing the American College of Surgeons National Surgical Quality Im... 2/11/2023
Zaeem H Nazir, Khawar Hussain, Ashfaq A Marghoob, Neil P Patel Ancillary techniques to improve dermoscopy specificity for skin cancer detection Although the use of dermoscopy has markedly improved both the sensitivity and specificity for skin cancer detection, there is still opportunity for improvement. Ancillary techniques provide additional ways to assess a lesion with the aim of improving our diagnostic ability with little extra cost. Us... 2/10/2023
Maya E Kotas, Neil N Patel, Emily K Cope, Jose G Gurrola, Andrew N Goldberg, Steven D Pletcher, Max A Seibold, Camille M Moore, Erin D Gordon IL-13-associated epithelial remodeling correlates with clinical severity in nasal polyposis CONCLUSIONS: These results demonstrate that cell-type alterations and prostaglandin E2 stimulation are key components of IL-13-induced epithelial remodeling in nasal polyposis, whereas IL-17 signaling is more prominent in CRS without polyps, and that clinical severity correlates with the degree of I... 2/3/2023
Caroline Y Noh, Valerie Y Chock, Shazia Bhombal, Enrico Danzer, Neil Patel, Alex Dahlen, Matthew T Harting, Kevin P Lally, Ashley H Ebanks, Krisa P Van Meurs, Congenital Diaphragmatic Hernia Study Group Early nitric oxide is not associated with improved outcomes in congenital diaphragmatic hernia CONCLUSIONS: Use of iNO in the first 3 days of life prior to ECLS was not associated with a reduction in mortality or ECLS use in either the regression models or the subgroup analyses. The widespread use of iNO in this vulnerable population requires reconsideration. 2/1/2023
Mounica Y Rao, Patrick M Sullivan, Cheryl Takao, Sarah Badran, Neil D Patel Safety of Continuing Anticoagulation Prior to Cardiac Catheterization in Pediatric Patients A Los Angeles Center Experience This is the first report specifically describing outcomes of pediatric patients who underwent cardiac catheterization while on uninterrupted anticoagulation. One hundred forty-four cardiac catheterizations were identified that met inclusion criteria at our institution from 11/2014 to 10/2019. The me... 2/1/2023
Sitapriya Moorthi, Amy Paguirigan, Minjeong Ko, Mary Pettinger, Anna C H Hoge, Anwesha Nag, Neil A Patel, Feinan Wu, Cassie Sather, Matthew P Fitzgibbon, Aaron R Thorner, Garnet L Anderson, Gavin Ha, Alice H Berger Somatic mutation but not aneuploidy differentiates lung cancer in never-smokers and smokers Lung cancer in never-smokers disproportionately affects older women. To understand the mutational landscape of this cohort, we performed detailed genome characterization of 73 lung adenocarcinomas from participants of the Women’s Health Initiative (WHI). We find enrichment of EGFR mutations in nev... 1/30/2023
Lauren T Roland, Ian M Humphreys, Christopher H Le, Jennifer M Babik, Christopher E Bailey, Lilangi S Ediriwickrema, Monica Fung, Joshua A Lieberman, Kelly R Magliocca, Hannah H Nam, Neville W Teo, Penelope C Thomas, Blair A Winegar, Jack L Birkenbeuel, Abel P David, Khodayar Goshtasbi, Patricia G Johnson, Elaine C Martin, Theodore V Nguyen, Neil N Patel, Hannan A Qureshi, Kaijun Tay, Milind Vasudev, Waleed M Abuzeid, Peter H Hwang, Aria Jafari, Matthew S Russell, Justin H Turner, Sarah K Wise, Edward C Kuan Diagnosis, Prognosticators, and Management of Acute Invasive Fungal Rhinosinusitis Multidisciplinary Consensus Statement and Evidence-Based Review with Recommendations CONCLUSION: Based on the currently available evidence, judicious utilization of a combination of history and physical examination, laboratory and histopathologic techniques, and endoscopy provide the cornerstone for accurate diagnosis of AIFS. In addition, AIFS is optimally managed by a multidiscipl... 1/21/2023
Anna M Stokolosa, Jack Thomas-Colwell, Katelyn K Dilley, Yueqiao Qu, Charlotte Cullip, Andrew E Heidari, Michelle Huang, Nathalie Kerrigan, Kellie Hsu, Jack Leonard, Karthik R Prasad, Brian J F Wong, Michael G Hill Electromechanical Cornea Reshaping for Refractive Vision Therapy The corneal stroma consists of orthogonally stacked collagen-fibril lamellae that determine the shape of the cornea and provide most of the refractive power of the eye. We have applied electromechanical reshaping (EMR), an electrochemical platform for remodeling cartilage and other semirigid tissues... 1/12/2023
Alpa Kanji, Khawar Hussain, Neil P Patel Opportunities for implementing a patient-initiated follow-up pathway for patients with psoriasis completing phototherapy We performed a retrospective case analysis to identify opportunities to introduce a patient-initiated follow-up (PIFU) pathway for patients with psoriasis completing narrowband ultraviolet B phototherapy at our centre. In total, 42 patients completed phototherapy between January 2016 and August 2018... 1/11/2023
Neil Patel, Yashendra Sethi, Nirja Kaka, Oroshay Kaiwan, Ishita Gupta, Rahma Sameh Shaheen, Shady Sapoor, Hitesh Chopra, Mihaela Simona Popoviciu, Talha Bin Emran, Simona Cavalu Acute Hepatitis of Unknown Origin in Pediatric Age Group Recent Outbreaks and Approach to Management Acute hepatitis has always been a public health concern, but the recent clustering of cases in various parts of the world has drawn some special attention. The sudden rise in cases has mainly been among the pediatric population of around 35 countries around the world, including developed countries s... 1/8/2023
Nwadi Igwe, Neil C. Patel, Tabish Aijaz Regenerative Therapy in Pain Regenerative medicine has been in existence for many decades, and many therapies have received Food and Drug Administration [FDA] approval for wound healing and orthopedic applications. Regenerative medicine is a field that applies biological science principles to promote regeneration by delivering ... 1/1/2023
Yashendra Sethi, Nidhi Uniyal, Vidhi Vora, Pratik Agarwal, Hamsa Murli, Archi Joshi, Neil Patel, Hitesh Chopra, Elfatih A Hasabo, Nirja Kaka Hypertension the Missed Modifiable Risk Factor for Diabetic Neuropathy a Systematic Review Diabetes and hypertension stand as the major non-infectious diseases affecting 34.2 million and 1.28 billion people respectively. The literature on the impact of diabetes on hypertension and vice versa is evolving. The major objectives of this review were to compile the evolving literature establish... 12/30/2022
Niklas J McKone, Joel R Martin, Sumona Mondal, Shantanu Sur, Italia Milani, Nelson Cortes, Shane V Caswell, Ali Boolani Factors Influencing Motivation to Perform Mental and Physical Tasks During the Initial Lockdown Period of the COVID-19 Drastic changes to lifestyles have occurred during the COVID-19 pandemic. An unintended consequence of stay at home orders is increased isolation and less social interaction for many people. For overall wellbeing it is important to stay both physically and mentally active; however, for many individu... 12/30/2022
Robert J Macielak, Amanda J Kull, Matthew L Carlson, Neil S Patel Disease recidivism after subtotal petrosectomy and ear canal closure CONCLUSIONS: Recidivistic disease often remains clinically silent for extended periods of time after STP. Planned follow-up - with imaging or second look surgery - to facilitate early detection should be considered. Undetected disease recurrence or development may result in morbidity in a proportion... 12/29/2022
Vikas S Gupta, Elizabeth C Popp, Ashley H Ebanks, Christopher E Greenleaf, Vidhya Annavajjhala, Neil Patel, Daniel K Robie, Damien J LaPar, Kevin P Lally, Matthew T Harting, Congenital Diaphragmatic Hernia Study Group Isolated aortic arch anomalies are associated with defect severity and outcome in patients with congenital diaphragmatic hernia CONCLUSIONS: IAAA in CDH are associated with increased mortality. This often simply reflects severity of the defect and thoracic anatomic derangement, as opposed to unique aortic pathology, given few CDH + IAAA patients undergo aortic intervention. 12/29/2022
Neil P Patel, Faisal Elali, Daniel Coban, Stuart Changoor, Neil V Shah, Kumar Sinha, Ki Hwang, Michael Faloon, Carl B Paulino, Arash Emami The 5-factor modified Frailty Index mFI-5 predicts adverse outcomes after elective Anterior Lumbar Interbody Fusion ALIF CONCLUSIONS: The mFI-5 is an independent predictor for 30-day postoperative complications, readmissions, UTI, pneumonia, and unplanned intubations following elective ALIF surgery in adults over the age of 50. 12/29/2022
Karen L Florio, Darcy White, Kensey Gosch, Neil Patel, Tara Daming, Emily M Williams, Sarah Hostetter, Rebecca Gray, Lynne Nelson, Kathleen Swearingen, Christine Henricks, Anna Grodzinsky, Valerie Rader, John Lee, Anthony Magalski, Laura Schmidt Patient-Perceived Satisfaction and Knowledge Uptake in a Combined Cardio-Obstetrics Clinic Heart disease is the leading cause of pregnancy-related mortality in the United States and has led to the development of combined cardio-obstetrics (COB) clinics as a model for prenatal care. In other areas of medicine, these types of collaborative care models have shown improvement in morbidity, mo... 12/22/2022
John P Marinelli, Neil S Patel, Christine M Lohse, John I Lane, Matthew L Carlson Cochlear promontory anatomy relevant to development of subendosteal and transpromontory electrodes using 192-section ultra-high resolution temporal bone CT imaging CONCLUSIONS: Cochlear promontory thickness can vary by almost 1.5 mm across patients and is significantly associated with patient sex, body mass index, and comorbid osteopenia/osteoporosis. Subendosteal and transpromontory electrode placement techniques must account for this degree of variability. 12/22/2022
Vikram Shivkumar, Dipali Nemade Hemichorea-Hemiballism as a Delayed Manifestation of Hyperglycemia A Case Report Hemichorea is characterized by involuntary, continuous, non-patterned movements on one side of the body. While it is most commonly caused by strokes, it can also be caused by metabolic derangements such as hyperglycemia. We present two patients who developed hemichorea in the setting of hyperglycemi... 12/19/2022
Asher C Park, Carmen K Chan, Dana M Hutchison, Urja Patel, Ellen M Hong, Earl Steward, Katelyn K Dilley, Naya L Sterritt, Sehwan Kim, Michael G Hill, Joon S You, Brian J F Wong In vivo electrochemical lipolysis of fat in a Yucatan pig model A proof of concept study CONCLUSIONS: ECLL results in selective damage and long-lasting changes to the adipose layer in vivo. These changes are dose-dependent, thus allowing for more precise contouring of target areas. P-ECLL has greater efficiency and control of total charge transfer compared to V-ECLL, suggesting that a l... 12/13/2022
Yashendra Sethi, Neil Patel, Nirja Kaka, Ami Desai, Oroshay Kaiwan, Mili Sheth, Rupal Sharma, Helen Huang, Hitesh Chopra, Mayeen Uddin Khandaker, Maha M A Lashin, Zuhal Y Hamd, Talha Bin Emran Artificial Intelligence in Pediatric Cardiology A Scoping Review The evolution of AI and data science has aided in mechanizing several aspects of medical care requiring critical thinking: diagnosis, risk stratification, and management, thus mitigating the burden of physicians and reducing the likelihood of human error. AI modalities have expanded feet to the spec... 12/11/2022
Karol P Budohoski, Robert C Rennert, Steven A Gordon, Amol Raheja, Cameron Brandon, J Curran Henson, Mohammed A Azab, Neil S Patel, Michael Karsy, Richard K Gurgel, Clough Shelton, William T Couldwell Factors associated with hearing outcomes after a middle fossa approach in 131 consecutive patients with vestibular schwannomas CONCLUSIONS: The hearing preservation rates after microsurgical resection of small VSs using the middle fossa approach are high, with 78% of patients maintaining AAO-HNS class A or B hearing. Poor hearing status at baseline, longer duration of anesthesia, and large overlap between the fundus of the ... 12/3/2022
Laura Valfré, Andrea Conforti, Francesco Morini, Neil Patel, Francesca Bevilacqua, Maria Chiara Cianci, Pietro Bagolan, Annabella Braguglia Unsolved problems in CDH follow-up In patients affected by CDH, survival beyond the neonatal period continues to increase thanks to technological and pharmacological improvements. Conversely, patients, families and caregivers are more and more frequently facing "new" complex late comorbidities, including chronic pulmonary and cardiac... 11/17/2022
Viren Punja, Thomas Capasso, Kelley M Ray, Laura Stokes, Joel Narveson, Fang Niu, Neil D Patel, Kaily Ewing, Carlos A Fernandez, Jessica Veatch, Eirc Kuncir The Impact of Relocating a Trauma Center Observations on Patient Injury Demographics and Resident Volumes Introduction Changing the physical zip code location of an academic trauma center may affect the distribution and surgical volume of its trauma patients. General surgical residency case log requirements may also be affected. This study describes the impact of moving a level I trauma center to a diff... 11/16/2022
Michael Camilleri, Thyagarajan Subramanian, Fernando Pagan, Stuart Isaacson, Ramon Gil, Robert A Hauser, Mary Feldman, Mark Goldstein, Rajeev Kumar, Daniel Truong, Nisha Chhabria, Benjamin L Walter, Jonathan Eskenazi, Robert Riesenberg, Daniel Burdick, Winona Tse, Eric Molho, Bradley Robottom, Perminder Bhatia, Srinath Kadimi, Kevin Klos, David Shprecher, Otto Marquez-Mendoza, Gonzalo Hidalgo, Stephen Grill, George Li, Howard Mandell, Mary Hughes, Sharisse Stephenson, Joel Vandersluis, Michael Pfeffer, Andrew Duker, Vikram Shivkumar, William Kinney, James MacDougall, Michael Zasloff, Denise Barbut Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease A Randomized Controlled Trial CONCLUSION: ENT-01 was safe and significantly improved constipation. 11/7/2022
Reena Pal, Sonam Maheshwari, Nirja Kaka, Neil Patel, Yashendra Sethi Knowledge, Attitude and Practices of Postpartum Females Regarding the Acceptance of Immediate Postpartum Contraception A Cross-Sectional Study From North India The immediate postpartum period is a great time to encourage the acceptance of contraceptive methods; the time is influenced by both emotional and physical factors. At this stage, the administration of intrauterine contraceptives is relatively easier with lesser complications due to the prior obstet... 11/7/2022
Abhi Shah, Viraj Panchal, Kashyap Patel, Zainab Alimohamed, Nirja Kaka, Yashendra Sethi, Neil Patel Pathogenesis and management of multiple sclerosis revisited CONCLUSIONS: The recent past has seen staggering inclusions to the management of multiple sclerosis catalyzing a significant turnabout in our approach to diagnosis, treatment, and prognosis. Since the advent of DMTs various other oral and injectable agents have been approved. The advances in MS ther... 10/24/2022
Aria M Jamshidi, Joel R Martin, Onur C Kutlu, Michael Y Wang Diaphragmatic Hernia With Incarcerated Spleen as a Complication After Lateral Anterior Column Realignment CONCLUSION: Iatrogenic diaphragmatic hernia with an intrathoracic spleen after direct lateral ACR is a risk spine surgeons should be aware of and address promptly. 10/13/2022
Eric E Babajanian, Erin C Carmichael, Steven A Gordon, Neil S Patel, Richard K Gurgel Cochlear Implantation in Patients With Known Cognitive Impairment What Are the Benefits CONCLUSIONS: This study demonstrates that patients with cognitive impairment before CI can experience improved hearing, no increased risk of complications, and good longevity after CI. Further prospective studies are needed to further define the utility of CI in patients with impaired cognition. 10/6/2022
Kyril L Cole, Eric Babajanian, Ryan Anderson, Steve Gordon, Neil Patel, Alis J Dicpinigaitis, Syed Faraz Kazim, Christian A Bowers, Richard K Gurgel Association of Baseline Frailty Status and Age With Postoperative Complications After Cochlear Implantation A National Inpatient Sample Study CONCLUSION: Among those evaluated, this study demonstrates that CI is a low-risk procedure in participants of all ages. Increasing frailty does not predispose to postoperative complications. However, frail patients are at additional risk for an eLOS and nonhome discharge. Short follow-up time, hospi... 10/3/2022
Amber M Abram, Michelle M Szewczyk, Seon G Park, Sumita S Sam, Haya B Eldana, Fadi J Koria, Joseph M Ferracciolo, Laura A Young, Hina Qadir, Aaron J Bonham, Fei Yang, Jonathan S Zora, Sara A Abdulelah, Neil A Patel, Ayah Koleilat, Malaka A Saleh, Jamal A Alhabeil, Shameel Khan, Ashootosh Tripathi, John G Palanci, Eric S Krukonis A Co-Association of Streptococcus mutans and Veillonella parvuladispar in Root Caries Patients and emIn Vitroem Biofilms Root caries in geriatric patients is a growing problem as more people are maintaining their natural teeth into advanced age. We determined the levels of various bacterial species previously implicated in root caries disease or health using quantitative real-time PCR in a pilot study of 7 patients wi... 9/21/2022
Richard K Gurgel, William T Couldwell, Neil S Patel, Lisa A Cannon-Albright Is There an Inherited Contribution to Risk for Sporadic Unilateral Vestibular Schwannoma Evidence of Familial Clustering CONCLUSION: These results provide strong evidence for an inherited predisposition to sporadic, unilateral VS. This study exhibits the value of genealogical resources with linked medical data for examining hypotheses regarding inherited predisposition. The high-risk unilateral VS pedigrees identified... 9/16/2022
Pugazhendhi Vijayaraman, Oscar Cano, Shunmuga Sundaram Ponnusamy, Manuel Molina-Lerma, Joseph Y S Chan, Santosh K Padala, Parikshit S Sharma, Zachary I Whinnett, Bengt Herweg, Gaurav A Upadhyay, Faiz A Subzposh, Neil R Patel, Dominik A Beer, Agnieszka Bednarek, Grzegorz Kielbasa, Roderick Tung, Kenneth A Ellenbogen, Marek Jastrzebski Left bundle branch area pacing in patients with heart failure and right bundle branch block Results from International LBBAP Collaborative-Study Group CONCLUSION: LBBAP is a feasible alternative to deliver CRT or physiologic ventricular pacing in patients with RBBB, HF, and LV dysfunction. 9/13/2022
Adam A Dmytriw, Mahmoud Dibas, Sherief Ghozy, Nimer Adeeb, Jose Danilo Bengzon Diestro, Kevin Phan, Hugo H Cuellar-Saenz, Ahmad Sweid, Sovann V Lay, Adrien Guenego, Leonardo Renieri, Ali Al Balushi, Guillaume Saliou, Markus Möhlenbruch, Robert W Regenhardt, Justin E Vranic, Ivan Lylyk, Paul M Foreman, Jay A Vachhani, Vedran Župančić, Muhammad U Hafeez, Caleb Rutledge, Muhammad Waqas, Vincent M Tutino, James D Rabinov, Yifan Ren, Clemens M Schirmer, Mariangela Piano, Anna L Kühn, Caterina Michelozzi, Stéphanie Elens, Robert M Starke, Ameer Hassan, Arsalaan Salehani, Peter Sporns, Jesse Jones, Marios Psychogios, Julian Spears, Boris Lubicz, Pietro Panni, Ajit S Puri, Guglielmo Pero, Christoph J Griessenauer, Hamed Asadi, Christopher J Stapleton, Adnan Siddiqui, Andrew F Ducruet, Felipe C Albuquerque, Rose Du, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Stavropoula Tjoumakaris, Jared Knopman, Mohammad A Aziz-Sultan, Nicola Limbucci, Pascal Jabbour, Christophe Cognard, Aman B Patel The Woven EndoBridge WEB Device for the Treatment of Intracranial Aneurysms Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium Several studies have shown promising outcomes of the Woven EndoBridge (WEB) device for the treatment of wide-necked intracranial bifurcation aneurysms. This is a multicenter study attempts to explore the changes in trends and treatment outcomes over time for WEB embolization of intracranial aneurysm... 9/6/2022
Elizabeth R Kahle, Neil Patel, Harini B Sreenivasappa, Michele S Marcolongo, Lin Han Targeting cell-matrix interface mechanobiology by integrating AFM with fluorescence microscopy Mechanosensing at the interface of a cell and its surrounding microenvironment is an essential driving force of physiological processes. Understanding molecular activities at the cell-matrix interface has the potential to provide novel targets for improving tissue regeneration and early disease inte... 9/2/2022
Neil Patel, Anna C Massolo, Ulrike S Kraemer, Florian Kipfmueller The heart in congenital diaphragmatic hernia Knowns, unknowns, and future priorities There is growing recognition that the heart is a key contributor to the pathophysiology of congenital diaphragmatic hernia (CDH), in conjunction with developmental abnormalities of the lung and pulmonary vasculature. Investigations to date have demonstrated altered fetal cardiac morphology, notably ... 9/2/2022
Carlos A Fernandez, Joel R Narveson, Ryan W Walters, Neil D Patel, Jessica M Veatch, Kaily L Ewing, Thomas J Capasso, Viren P Punja, Eirc J Kuncir Takotsubo Cardiomyopathy and Trauma The Role of Injuries as Physical Stressors CONCLUSIONS: TTC in traumatic injuries is common at both ends of the severity spectrum and has different sex distribution. TTC patients are predominantly females and have more commonly extremity trauma than head injury. Males are more severely injured and under mechanical ventilation. 9/1/2022
Shazia Bhombal, Neil Patel Diagnosis amp; management of pulmonary hypertension in congenital diaphragmatic hernia Congenital diaphragmatic hernia (CDH) contributes to neonatal morbidity and mortality worldwide. Pulmonary hypertension (PH) is a key component of CDH pathophysiology and critical consideration for management and therapeutic options. PH associated with CDH has traditionally been attributed to pulmon... 8/22/2022
Justin J Merrigan, Adam A Burke, Oladipo O Eddo, James Kearney, Daniel Marks, Joel R Martin Upper body push to pull ratios in law enforcement officer recruits CONCLUSION: Practitioners may benefit from examining eP2P and sP2P as they should not be used interchangeably. Future research should examine whether the P2P ratios are associated with injury and subsequent inability to successfully complete law enforcement training academies. 8/21/2022
Neil V Shah, David J Kim, Neil Patel, George A Beyer, Douglas A Hollern, Adam J Wolfert, Nathan Kim, Daniel E Suarez, Dan Monessa, Peter L Zhou, Hassan M Eldib, Peter G Passias, Frank J Schwab, Virginie Lafage, Carl B Paulino, Bassel G Diebo The 5-factor modified frailty index mFI-5 is predictive of 30-day postoperative complications and readmission in patients with adult spinal deformity ASD CONCLUSION: The mFI-5 score predicted complications and postoperative events in the ASD population. The mFI-5 may effectively predict 30-day readmissions. Further research is needed to identify the benefits and predictive value of mFI-5 as a risk assessment tool. 8/18/2022
Nirja Kaka, Yashendra Sethi, Neil Patel, Okashah Kaiwan, Yana Al-Inaya, Kshitij Manchanda, Nidhi Uniyal Endocrine manifestations of chronic kidney disease and their evolving management A systematic review CONCLUSION: Increased advertence regarding the pathology, impact, and management of these endocrine derangements can help in reducing morbidity as well as mortality in the CKD patients by allowing prompt individualized treatment. Moreover, with timely and appropriate intervention, a long-term reduct... 8/14/2022
Ratnam K Santoshi, Reema Patel, Neil S Patel, Varinder Bansro, Gurdeep Chhabra A Comprehensive Review of Thrombocytopenia With a Spotlight on Intensive Care Patients Thrombocytopenia is a common entity seen in ICU patients and is associated with increased morbidity such as bleeding and transfusions, and mortality in ICU patients. Various mechanisms such as decreased platelet production, sequestration, destruction, consumption, and sometimes a combination of thes... 8/11/2022
Jack Thomas-Colwell, Arvin Sookezian, Daniel A Kurtz, Jeremy Kallick, Lawrence M Henling, Troy A Stich, Michael G Hill, Bryan M Hunter Tuning CobaltII Phosphine Complexes to be Axially Ambivalent We report the isolation and characterization of a series of three cobalt(II) bis(phosphine) complexes with varying numbers of coordinated solvent ligands in the axial position. X-ray quality crystals of [Co(dppv)(2)][BF(4)](2) (1), [Co(dppv)(2)(NCCH(3))][BPh(4)](2) (2), and [Co(dppv)(2)(NCCH(3))(2)]... 8/3/2022
Nikesh Patel, Neil P Patel Anogenital dermatology caseload analysis of new outpatient referrals at a single dermatology centre Little is known about the volume of outpatient referrals for anogenital dermatoses received by NHS dermatology departments. We undertook a caseload analysis at our centre and found 6.0% of GP referrals to Dermatology were for anogenital dermatoses. This has important implications for training in thi... 7/30/2022
Irakliy Abramov, Marian T Park, Evgenii Belykh, Alexander B Dru, Yuan Xu, Timothy C Gooldy, Lea Scherschinski, S Harrison Farber, Andrew S Little, Randall W Porter, Kris A Smith, Michael T Lawton, Jennifer M Eschbacher, Mark C Preul Intraoperative confocal laser endomicroscopy prospective in vivo feasibility study of a clinical-grade system for brain tumors CONCLUSIONS: The clinical-grade CLE system allows in vivo, intraoperative, high-resolution cellular visualization of tissue microstructure and identification of lesional tissue patterns in real time, without the need for tissue preparation. 7/28/2022
Jose Danilo Bengzon Diestro, Mahmoud Dibas, Nimer Adeeb, Robert W Regenhardt, Justin E Vranic, Adrien Guenego, Sovann V Lay, Leonardo Renieri, Ali Al Balushi, Eimad Shotar, Kevin Premat, Kareem El Naamani, Guillaume Saliou, Markus A Möhlenbruch, Ivan Lylyk, Paul M Foreman, Jay A Vachhani, Vedran Župančić, Muhammad U Hafeez, Caleb Rutledge, Hamid Rai, Vincent M Tutino, Shervin Mirshani, Sherief Ghozy, Pablo Harker, Naif M Alotaibi, James D Rabinov, Yifan Ren, Clemens M Schirmer, Oded Goren, Mariangela Piano, Anna Luisa Kuhn, Caterina Michelozzi, Stephanie Elens, Robert M Starke, Ameer Hassan, Arsalaan Salehani, Anh Nguyen, Jesse Jones, Marios Psychogios, Julian Spears, Carmen Parra-Fariñas, Maria Bres Bullrich, Michael Mayich, Mohamed M Salem, Jan-Karl Burkhardt, Brian T Jankowitz, Ricardo A Domingo, Thien Huynh, Rabih Tawk, Christian Ulfert, Boris Lubicz, Pietro Panni, Ajit S Puri, Guglielmo Pero, Christoph J Griessenauer, Hamed Asadi, Adnan Siddiqui, Andrew F Ducruet, Felipe C Albuquerque, Rose Du, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Reddy Boddu, Christopher J Stapleton, Jared Knopman, Pascal Jabbour, Stavropoula Tjoumakaris, Frédéric Clarençon, Nicola Limbucci, Mohammad A Aziz-Sultan, Hugo H Cuellar-Saenz, Christophe Cognard, Aman B Patel, Adam A Dmytriw Intrasaccular flow disruption for ruptured aneurysms an international multicenter study CONCLUSION: There was no significant difference in both the radiologic outcomes and complications between unruptured and ruptured aneurysms. Our findings support the feasibility of treatment of ruptured aneurysms with the WEB device. 7/22/2022
Srirupa Hari Gopal, Neil Patel, Caraciolo J Fernandes Use of Prostaglandin E1 in the Management of Congenital Diaphragmatic Hernia-A Review Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly, whose presentation is complicated by pulmonary hypertension (PH), pulmonary hypoplasia, and myocardial dysfunction, each of which have significant impact on short-term clinical management and long-term outcomes. Despite many advance... 7/18/2022
Neil Patel, Deborah D Chin, Gregory A Magee, Eun Ji Chung Therapeutic Response of miR-145 Micelles on Patient-Derived Vascular Smooth Muscle Cells During atherosclerosis, vascular smooth muscle cells (VSMCs) undergo a phenotypic transition from a healthy contractile state into pathological phenotypes including a proliferative and migratory, synthetic phenotype and osteochondrogenic-like phenotype that exacerbate plaques. Thus, inhibiting the t... 7/5/2022
Tamara Lynne B Aqui, Neil K Patel, Yolanda Zhang, Scott Kubomoto Ipsilateral Facial Hyperhidrosis in a Patient With Squamous Cell Carcinoma of the Lung While anhidrosis in Horner's Syndrome is a well-documented result of apical lung malignancies impinging on the sympathetic pathway traveling through the upper lobe of the lung, its opposite effect, hyperhidrosis, is a seldom reported consequence. Hyperhidrosis occurs as a result of irritation of the... 6/15/2022
Augusto Zani, Wendy K Chung, Jan Deprest, Matthew T Harting, Tim Jancelewicz, Shaun M Kunisaki, Neil Patel, Lina Antounians, Pramod S Puligandla, Richard Keijzer Congenital diaphragmatic hernia Congenital diaphragmatic hernia (CDH) is a rare birth defect characterized by incomplete closure of the diaphragm and herniation of fetal abdominal organs into the chest that results in pulmonary hypoplasia, postnatal pulmonary hypertension owing to vascular remodelling and cardiac dysfunction. The ... 6/1/2022
Buki Kwon, Mervin M Fansler, Neil D Patel, Jihye Lee, Weirui Ma, Christine Mayr Enhancers regulate 3 end processing activity to control expression of alternative 3UTR isoforms Multi-UTR genes are widely transcribed and express their alternative 3'UTR isoforms in a cell type-specific manner. As transcriptional enhancers regulate mRNA expression, we investigated if they also regulate 3'UTR isoform expression. Endogenous enhancer deletion of the multi-UTR gene PTEN did not i... 5/17/2022
Ryan A Romans, Jimmy C Lu, Sowmya Balasubramanian, Wendy Whiteside, Sunkyung Yu, Osamah T Aldoss, Aimee K Armstrong, Brian A Boe, David T Balzer, Jason T Christensen, Thomas K Jones, Britton Keeshan, Daniel McLennan, George T Nicholson, Neil Patel, Arash Salavitabar, Shabana Shahanavaz, Patrick M Sullivan, Mariel E Turner, Jeffrey D Zampi Cardiac Magnetic Resonance to Predict Coronary Artery Compression in Transcatheter Pulmonary Valve Implantation Into Conduits CONCLUSIONS: CMR can help predict the risk for CA compression during TPVi in RV-PA conduits but cannot completely exclude CA compression. CMR may assist in patient selection and counseling families prior to TPVi, although balloon testing remains essential. 5/5/2022
Nimer Adeeb, Mahmoud Dibas, Jose Danilo Bengzon Diestro, Kevin Phan, Hugo H Cuellar-Saenz, Ahmad Sweid, Sovann V Lay, Adrien Guenego, Assala Aslan, Leonardo Renieri, Sri Hari Sundararajan, Guillaume Saliou, Markus Möhlenbruch, Robert W Regenhardt, Justin E Vranic, Ivan Lylyk, Paul M Foreman, Jay A Vachhani, Vedran Župančić, Muhammad U Hafeez, Caleb Rutledge, Muhammad Waqas, Vincent M Tutino, James D Rabinov, Yifan Ren, Clemens M Schirmer, Mariangela Piano, Anna L Kuhn, Caterina Michelozzi, Stephanie Elens, Robert M Starke, Ameer Hassan, Arsalaan Salehani, Alex Brehm, MajdEddin MohammedAli, Jesse Jones, Marios Psychogios, Julian Spears, Boris Lubicz, Pietro Panni, Ajit S Puri, Guglielmo Pero, Christoph J Griessenauer, Hamed Asadi, Adnan Siddiqui, Andrew Ducruet, Felipe C Albuquerque, Rose Du, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Christopher J Stapleton, Srikanth Boddu, Jared Knopman, Mohammad A Aziz-Sultan, Nicola Limbucci, Pascal Jabbour, Christophe Cognard, Aman B Patel, Adam A Dmytriw Comparing treatment outcomes of various intracranial bifurcation aneurysms locations using the Woven EndoBridge WEB device CONCLUSION: To our knowledge, this is the most extensive study to date that compares the treatment of different intracranial bifurcation aneurysms using the WEB device. Basilar tip and ICA bifurcation aneurysms showed significantly higher rates of aneurysm occlusion than other locations. 4/28/2022
Nimer Adeeb, Mahmoud Dibas, Jose Danilo Bengzon Diestro, Hugo H Cuellar-Saenz, Ahmad Sweid, Sandeep Kandregula, Sovann V Lay, Adrien Guenego, Leonardo Renieri, Sri Hari Sundararajan, Guillaume Saliou, Assala Aslan, Markus Möhlenbruch, Justin E Vranic, Robert W Regenhardt, Amey Savardekar, Ahmed Mamilly, Ivan Lylyk, Paul M Foreman, Jay A Vachhani, Vedran Župančić, Muhammad U Hafeez, Caleb Rutledge, Muhammad Waqas, Carmen Parra Farinas, Vincent M Tutino, Yasuaki Inoue, Shervin Mirshahi, James D Rabinov, Yifan Ren, Clemens M Schirmer, Mariangela Piano, Anna L Kühn, Caterina Michelozzi, Stéphanie Elens, Robert M Starke, Ameer Hassan, Arsalaan Salehani, Peter Sporns, Alex Brehm, Jesse Jones, Marios Psychogios, Julian Spears, Boris Lubicz, Pietro Panni, Ajit S Puri, Guglielmo Pero, Christoph J Griessenauer, Hamed Asadi, Christopher J Stapleton, Adnan Siddiqui, Andrew F Ducruet, Felipe C Albuquerque, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Jared Knopman, Mohammad A Aziz-Sultan, Nicola Limbucci, Pascal Jabbour, Christophe Cognard, Aman B Patel, Adam A Dmytriw Multicenter Study for the Treatment of Sidewall versus Bifurcation Intracranial Aneurysms with Use of Woven EndoBridge WEB Background The Woven EndoBridge (WEB) device was explicitly designed for wide-neck intracranial bifurcation aneurysms. Small-scale reports have evaluated the off-label use of WEB devices for the treatment of sidewall aneurysms, with promising outcomes. Purpose To compare the angiographic and clinica... 4/19/2022
Neil Patel, Radu Mihai Long-term Cure of Primary Hyperparathyroidism After Scan-Directed Parathyroidectomy Outcomes From A UK Endocrine Surgery Unit CONCLUSION: Recurrence after scan-directed unilateral neck exploration occurred in 4% of patients after a long disease-free interval. Only one patient had recurrent disease within 1-year of primary surgery. The data suggest that bilateral neck exploration at the time of initial operation, in this se... 4/12/2022
Guglielmo Salvatori, Domenico Umberto De Rose, Anna Claudia Massolo, Neil Patel, Irma Capolupo, Paola Giliberti, Melania Evangelisti, Pasquale Parisi, Alessandra Toscano, Andrea Dotta, Giovanni Di Nardo Current Strategies to Optimize Nutrition and Growth in Newborns and Infants with Congenital Heart Disease A Narrative Review (1) Objective: This review aims to identify the clinical and practical barriers to optimizing nutrition in newborn infants with congenital heart disease (CHD) and to describe updated evidence-based recommendations for clinical and nutritional management of these patients in a narrative review. (2) R... 4/12/2022
Ron Gadot, Adrish Anand, Terence Verla, Matthew Muir, Sebastian J Winocour, Edward M Reece, Alexander E Ropper Complex Wound Closure in Adult Spinal Deformity Surgery Reduces Complications in High-Risk Patients CONCLUSIONS: Prophylactic involvement of plastic surgery in ASD surgery wound closure may improve wound outcomes in higher risk patients. A multidisciplinary approach with plastic and spine surgeons may lessen the risk of wound complications in high-risk spine surgeries. 3/25/2022
Carlos A Fernandez, Joel R Narveson, Fang Niu, Elizabeth Norton, Emily C Brown, Viren Punja, Jessica M Veatch, Thomas Capasso, Neil D Patel, Kaily Ewing, Eric Kuncir In-hospital outcomes of intercostal nerve cryoablation and surgical stabilization of rib fractures CONCLUSION: Combining INCA with SSRF may further improve in-hospital outcomes for patients with traumatic rib fractures. 3/23/2022
Amrita Basu, Neil G Patel, Elijah D Nicholson, Ryan J Weiss Spatiotemporal diversity and regulation of glycosaminoglycans in cell homeostasis and human disease Glycosaminoglycans (GAGs) are long, linear polysaccharides that are ubiquitously expressed on the cell surface and in the extracellular matrix of all animal cells. These complex carbohydrates play important roles in many cellular processes and have been implicated in many disease states, including c... 3/16/2022
Malcolm Anastasius, Richard Ro, Michael Gavalas, Neil Patel, Francesca Romana Prandi, Gilbert H L Tang, Parasuram Krishnamoorthy, Samin K Sharma, Annapoorna Kini, Stamatios Lerakis The Effect of TAVR on Left Ventricular and Left Atrial Mechanics in Patients with Aortic Stenosis Background. Measures of adverse cardiac remodeling, left ventricular global longitudinal strain (LVGLS) and left atrial (LA) phasic function, are predictive of cardiac events in patients with severe aortic stenosis (AS). How these parameters of cardiac function change following TAVR requires further... 2/24/2022
Amoah Yeboah-Korang, Ahmed Memon, Neil Patel, Andrea Portocarrero-Castillo, Askanda Osman, David Kleesattel, Carmen Lopez, Jeremy Louissaint, Kenneth Sherman, Robert Fontana Impact of Prior Drug Allergies on the Risk, Clinical Features, and Outcomes of Idiosyncratic Drug-Induced Liver Injury in Adults CONCLUSION: A prior drug allergy history was not associated with a greater likelihood of developing DILI compared to other causes of acute liver injury. However, the probable DILI patients with a history of prior drug allergy tended to have less severe liver injury and clinical outcomes. The low rat... 2/5/2022
Mahmoud Dibas, Nimer Adeeb, Jose Danilo Bengzon Diestro, Hugo H Cuellar, Ahmad Sweid, Sovann V Lay, Adrien Guenego, Assala Aslan, Leonardo Renieri, Sri Hari Sundararajan, Guillaume Saliou, Markus Möhlenbruch, Robert W Regenhardt, Justin E Vranic, Ivan Lylyk, Paul M Foreman, Jay A Vachhani, Vedran Župančić, Muhammad U Hafeez, Caleb Rutledge, Muhammad Waqas, Vincent M Tutino, James D Rabinov, Yifan Ren, Clemens M Schirmer, Mariangela Piano, Anna L Kühn, Caterina Michelozzi, Stéphanie Elens, Robert M Starke, Ameer E Hassan, Arsalaan Salehani, Peter Sporns, Jesse Jones, Marios Psychogios, Julian Spears, Boris Lubicz, Pietro Panni, Ajit S Puri, Guglielmo Pero, Christoph J Griessenauer, Hamed Asadi, Christopher J Stapleton, Adnan Siddiqui, Andrew F Ducruet, Felipe C Albuquerque, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Jared Knopman, Mohammad A Aziz-Sultan, Nicola Limbucci, Pascal Jabbour, Christophe Cognard, Aman B Patel, Adam A Dmytriw Transradial versus transfemoral access for embolization of intracranial aneurysms with the Woven EndoBridge device a propensity score-matched study CONCLUSIONS: TRA has comparable outcomes, with shorter procedure and fluoroscopy time, to TFA for aneurysm embolization with the WEB device. 2/4/2022
Simple Bhadania, Neena Bhalodiya, Yashendra Sethi, Nirja Kaka, Swati Mishra, Neil Patel, Asad Ullah Wasim, Saumya S Joshi, Kenisha Shah Hyperferritinemia and the Extent of Mucormycosis in COVID-19 Patients Introduction Coronavirus disease 2019 (COVID-19) disease attributed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown associations with various fungal opportunistic infections such as mucormycosis, invasive candidiasis, and aspergillosis, which have contributed to the mortali... 2/1/2022
Bryndan W Lindsey, Daniel E Shookster, Joel R Martin, Nelson N Cortes Predictive Accuracy of the Nelson Equation via BodPod Compared to Commonly Used Equations to Estimate Resting Metabolic Rate in Adults Indirect calorimetry (IC) is considered the gold standard for assessing resting metabolic rate (RMR). However, many people do not have access to IC devices and use prediction equations for RMR estimation. Equations using fat free mass (FFM) as a predictor have been developed to estimate RMR, as a st... 1/31/2022
Katelyn K Dilley, Pamela A Borden, Yueqiao Qu, Andrew E Heidari, Karthik R Prasad, Yan Li, Chung Ho Sun, Zhongping Chen, Sehwan Kim, Michael G Hill, Brian J F Wong Potential-Driven Electrochemical Clearing of Ex Vivo Alkaline Corneal Injuries CONCLUSIONS: P-ECT may be a means to correct alkaline CCI. Collagen fibril orientation does not change after NaOH exposure or P-ECT, suggesting that no irreversible matrix level fiber changes occur. Further studies are required to determine the mechanism for corneal clearing and to ascertain the opt... 1/21/2022
Sakshi Prasad, Abdulrahim Mehadi, Nirja Kaka, Sharan Jhaveri, Chaithanya Avanthika, Neil Patel, Ivan Augustine, Ali Issani Diagnostic protocols and newer treatment modalities for cluster headache Cluster Headaches are one of the most arguably severe forms of primary headache syndrome that affects humans. Although it is relatively uncommon, it has a significant impact on the quality of life. It is a multifactorial disease that has risk factors ranging from seasonal changes, lifestyle habits t... 1/10/2022
Brian Au, Neil B Patel, Clair N Smith, Patrick R Burns Short- to Intermediate-Term Radiographic Outcomes Following Cotton Osteotomy The cotton osteotomy or the medial cuneiform opening wedge osteotomy has been a common adjunct procedure in flatfoot reconstruction to correct for forefoot varus or a dorsiflexed first ray. The main goal of the study is to retrospectively review outcomes specifically in the short-intermediate term f... 1/3/2022
Eric E Babajanian, Neil S Patel, Richard K Gurgel The Impact of Cochlear Implantation Cognitive Function, Quality of Life, and Frailty in Older Adults This review examines the relationship between cochlear implantation and cognition and quality of life in older adults, as well as how frailty affects outcomes for older patients with cochlear implants. A growing body of evidence suggests that there is a strong association between hearing loss and co... 12/16/2021
Steven A Gordon, Ashley M Nassiri, Colin L Driscoll, Matthew L Carlson, Neil S Patel Auricular Cartilage Resection for Treatment-Refractory Idiopathic Chronic Chondritis A Case Series CONCLUSIONS: Surgical excision of diseased cartilage as a result of idiopathic chronic chondritis is an effective treatment in those cases refractory to antibiotics and incision and drainage, and should be considered in the treatment algorithm for similar patients, potentially offering definitive cu... 12/10/2021
Alana Aylward, Steven A Gordon, Morganne Murphy-Meyers, Chelsea McCarty Allen, Neil S Patel, Richard K Gurgel Caregiver Quality of Life After Cochlear Implantation in Older Adults CONCLUSIONS: Higher QOL scores were found among caregivers of healthier, female CI recipients. Patient hearing measurements did not correspond with better caregiver QOL. 12/2/2021
Daniel A Kurtz, Jibo Zhang, Arvin Sookezian, Jeremy Kallick, Michael G Hill, Bryan M Hunter A Cobalt Phosphine Complex in Five Oxidation States Here we report electrochemical, spectroscopic, and crystallographic characterization of a redox series of cobalt complexes in five sequential oxidation states. A simple bidentate phosphine ligand, cis-1,2-bis(diphenylphosphino)ethylene (dppv), allows for isolation of the 3+, 2+, 1+, 0, and 1- oxidat... 11/23/2021
Maria G Valadez, Neil Patel, Vince Chong, Brant A Putnam, Ashkan Moazzez, Darin Saltzman, Dennis Y Kim Short Courses of Antibiotics Are Safe in Necrotizing Soft Tissue Infections CONCLUSION: Provided adequate surgical debridement, similar outcomes in morbidity and mortality suggest antibiotic courses of 7 days or less are equally safe compared to longer courses. 10/27/2021
Juliet Emamaullee, Sara Khan, Carly Weaver, Cameron Goldbeck, George Yanni, Rohit Kohli, Yuri Genyk, Shengmei Zhou, Nick Shillingford, Patrick M Sullivan, Cheryl Takao, Jon Detterich, Paul F Kantor, John D Cleveland, Cynthia Herrington, S Ram Kumar, Vaughn Starnes, Sarah Badran, Neil D Patel Non-invasive biomarkers of Fontan-associated liver disease CONCLUSIONS: In this large, relatively homogeneous adolescent population in terms of age, ethnicity, and Fontan duration, bridging fibrosis was observed in 35% of patients within the first decade post-Fontan. Bridging fibrosis was associated with worse survival. Changes in platelet counts, even year... 10/25/2021
Irakliy Abramov, Alexander B Dru, Evgenii Belykh, Marian T Park, Liudmila Bardonova, Mark C Preul Redosing of Fluorescein Sodium Improves Image Interpretation During Intraoperative emEx Vivoem Confocal Laser Endomicroscopy of Brain Tumors CONCLUSIONS: The decay of the FNa signal is directly associated with image brightness and contrast. The qualitative interpretation scores of images were highest for the FNa redose imaging group. Redosing with FNa to improve the utility of CLE imaging should be considered a safe and beneficial strate... 10/18/2021
Samir B Pancholy, Purveshkumar Patel, Gaurav A Patel, Dhara D Patel, Neil R Patel, Elizabeth A Pattara, Tejas M Patel Effects of previous coronary artery bypass graft surgery on in-hospital mortality in ST-segment elevation myocardial infarction National dataset analysis CONCLUSION: STEMI patients with previous CABG have a significantly higher IHM compared to those without previous CABG. PPCI improves IHM with no independent mortality disadvantage attributable to previous CABG. 10/6/2021
Steven A Gordon, Alana Aylward, Neil S Patel, Christian Bowers, Angela P Presson, Ken R Smith, Norman L Foster, Richard K Gurgel Does Frailty or Age Increase the Risk of Postoperative Complications Following Cochlear Implantation CONCLUSIONS: CI is safe for elderly and frail patients and carries no additional risk of complications when compared to younger, healthier patients. While medical comorbidities should always be considered perioperatively, this study supports the notion that implantation is low risk in older, frail p... 10/1/2021
Parikshit S Sharma, Neil R Patel, Venkatesh Ravi, Dipen V Zalavadia, Sujitraj Dommaraju, Varun Garg, Timothy R Larsen, Angela M Naperkowski, Jeremiah Wasserlauf, Kousik Krishnan, Wilson Young, Parash Pokharel, Jess W Oren, Randle H Storm, Richard G Trohman, Henry D Huang, Faiz A Subzposh, Pugazhendhi Vijayaraman Clinical outcomes of left bundle branch area pacing compared to right ventricular pacing Results from the Geisinger-Rush Conduction System Pacing Registry CONCLUSION: LBBAP resulted in improved clinical outcomes compared to RVP. Higher burden of ventricular pacing (>20%) was the primary driver of these outcome differences. 9/5/2021
Julie Highland, Steven Gordon, Deepika Reddy, Neil Patel Ototoxicity and Teprotumumab CONCLUSIONS: This is one of the first descriptive cases of ototoxicity resulting in irreversible sensorineural hearing loss in the setting of treatment with teprotumumab. Periodic audiologic evaluations should be recommended to patients on teprotumumab. 8/27/2021
Manas Dave, Carly Dixon, Neil Patel An educational evaluation of learner experiences in dentistry open-book examinations Introduction The COVID-19 pandemic resulted in substantial global disruptions, with many universities restructuring their examinations to open-book assessments. In this format, learners are allowed to use revision notes, textbooks and other permitted material during their examination. Traditionally,... 8/27/2021
Andrew E Heidari, Ellen M Hong, Asher Park, Tiffany T Pham, Earl Steward, Lily Y Chen, Yueqiao Qu, Brandyn S Dunn, Soo H Seo, Urja Patel, Katelyn Dilley, Amir A Hakimi, Adeela Syed, Sehwan Kim, Michael G Hill, Joon S You, Brian J F Wong Exploring feedback-controlled versus open-circuit electrochemical lipolysis in ex vivo and in vivo porcine fat A feasibility study CONCLUSIONS: V-ECLL and P-ECLL at the aforementioned dosimetry parameters both achieved fat necrosis by adipocyte membrane lysis and denuclearization. The -2.5 V and -3.5 V P-ECLL treatments created spatially similar fat necrotic effects when compared to the 5 V V-ECLL treatment. Quantitatively, tot... 8/19/2021
Pugazhendhi Vijayaraman, Neil Patel, Shaun Colburn, Dominik Beer, Angela Naperkowski, Faiz A Subzposh His-Purkinje Conduction System Pacing in Atrioventricular Block New Insights Into Site of Conduction Block CONCLUSIONS: HPCSP pacing was successfully performed in 97% of unselected patients with AVB irrespective of the site of conduction block. True infra-Hisian block (distal His-Purkinje conduction disease) is rare. HBP and LBBAP were complementary in achieving stable and low capture thresholds. 8/16/2021
Gursahib Sohal, Manas Dave, Neil Patel Dental implications of some commonly prescribed medicines Several medicines can have an impact on oral health or have implications for dental treatment. It is important that general dental practitioners review the medicines that their patients are taking and consider their potential impact. In this article we highlight some of the medicines or groups of me... 8/11/2021
Neil Patel, Deborah D Chin, Eun Ji Chung Exosomes in Atherosclerosis, a Double-Edged Sword Their Role in Disease Pathogenesis and Their Potential as Novel Therapeutics Cardiovascular disease (CAD) due to atherosclerosis is a major cause of death worldwide. The development of atherosclerosis involves intercellular communication facilitated by exosomes secreted from vascular endothelial cells (VECs), vascular smooth muscle cells (VSMCs), immune cells, and platelets.... 7/27/2021
Adela Nano, Ariel L Furst, Michael G Hill, Jacqueline K Barton DNA Electrochemistry Charge-Transport Pathways through DNA Films on Gold Over the past 25 years, collective evidence has demonstrated that the DNA base-pair stack serves as a medium for charge transport chemistry in solution and on DNA-modified gold surfaces. Since this charge transport depends sensitively upon the integrity of the DNA base pair stack, perturbations in b... 7/26/2021
Aaron L Zebolsky, Neil Patel, Chase M Heaton, Andrea M Park, Rahul Seth, P Daniel Knott Patient-Reported Aesthetic and Psychosocial Outcomes After Microvascular Reconstruction for Head and Neck Cancer CONCLUSIONS AND RELEVANCE: The findings of this cross-sectional, web-based survey study suggest that osteocutaneous reconstruction and adjuvant therapy independently increase the risk of poor patient-reported long-term aesthetic satisfaction, which correlated with impaired appearance-related psychos... 7/22/2021
Neil N Patel, Aaron Lee Zebolsky, Andrea M Park, Rahul Seth, Philip D Knott Smile Outcomes of an Externally Scarless, Intraoral Orthodromic Temporalis Tendon Transfer Background: Temporalis tendon transfer (TTT) often relies on external incisions in the nasolabial fold, temporal region, or both. Herein, we studied smile outcomes of a TTT technique via a single intraoral incision without external skin incisions. Objective: To measure the difference in static perio... 7/21/2021
Krutika Srivastava, Neil Patel, Malek Tabbara, Aaron Liew, Iman Zaghloul, Mattia M Migliore, Rania A Mekary Thromboembolism, Bleeding, and Mortality Incidence of Direct Oral Anticoagulants Versus Warfarin Postbariatric Surgery CONCLUSION: The results of our meta-analysis remain hypothesis-generating, providing rationale for future randomized controlled trial design or well-designed comparative observational studies. Currently, it does not support the change in the current recommendation from warfarin to DOACs following ba... 7/17/2021
Hilary C McCrary, Eric Babajanian, Neil Patel, Sara Yang, Matthew Kircher, Matthew L Carlson, Richard K Gurgel Superior Semicircular Canal Dehiscence Syndrome Following Head Trauma A Multi-institutional Review CONCLUSION: Head trauma may be a potentiating event for SSCD syndrome. This study advances the hypothesis that these patients likely have underlying radiographic SSCD prior to their trauma, and a traumatic event increases in intra-vestibular or intracranial pressures, unmasking SSCD syndrome. 7/17/2021
Neil S Patel, Matthew L Carlson, Michael J Link, Brian A Neff, Jamie J Van Gompel, Colin L W Driscoll Cochlear implantation after radiosurgery for vestibular schwannoma CONCLUSIONS: Most patients who underwent CI following SRS for VS enjoyed access to sound at near-normal levels, with the majority achieving good open-set speech understanding. Implantation can be performed immediately following SRS or in a delayed fashion, depending on hearing status as well as othe... 7/12/2021
Terence Verla, Aditya Vedantam, Robert Y North, David S Xu, Michael R Raber, Alfonso Fuentes, Nelson Eddie Liou, Alexander E Ropper Surgical Management of Postradiation, Dropped Head Spinal Deformity in Patients with Head and Neck Cancer CONCLUSIONS: Surgical correction of postradiation dropped head spinal deformity involving anterior and posterior fixation with osteotomies provides improvement in functional and radiographic outcomes as shown in our series. These cases are technically challenging and have a high rate of perioperativ... 7/10/2021
Dipali Nemade, Thyagarajan Subramanian, Vikram Shivkumar An Update on Medical and Surgical Treatments of Parkinsons Disease Parkinson's disease (PD) is characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta and other neuronal populations. The worldwide prevalence of PD is over 7 million and has been increasing more rapidly than many other neurodegenerative disorders. PD symptoms can b... 7/5/2021
Neil Patel, Kathryn Kinmond, Pauline Jones, Pamela Birks, Monica A Spiteri Validation of COPDPredict Unique Combination of Remote Monitoring and Exacerbation Prediction to Support Preventative Management of COPD Exacerbations CONCLUSION: High sensitivity indicates that if there is an exacerbation, COPDPredict™ informs patients and clinicians accurately. The high negative predictive value implies that when an exacerbation is not indicated by COPDPredict™, risk of an exacerbation is low. Thus, COPDPredict™ provides safe, p... 6/30/2021
Chandra Waddington, Nicole R van Veenendaal, Karel O'Brien, Neil Patel, International Steering Committee for Family Integrated Care Family integrated care Supporting parents as primary caregivers in the neonatal intensive care unit Family integrated care (FICare) is a collaborative model of neonatal care which aims to address the negative impacts of the neonatal intensive care unit (NICU) environment by involving parents as equal partners, minimizing separation, and supporting parent-infant closeness. FICare incorporates psych... 6/28/2021
Ashley M Nassiri, John C Benson, Karl W Doerfer, Elizabeth L Perkins, Alex D Sweeney, Neil S Patel, Seilesh C Babu, Alejandro Rivas, John I Lane, Matthew L Carlson Absent pyramidal eminence and stapedial tendon associated with congenital stapes footplate fixation Intraoperative and radiographic findings CONCLUSIONS: This study identifies a clinically pragmatic association between an absent pyramidal eminence identified on high-resolution CT and the diagnosis of CSFF. In a condition that otherwise generally lacks distinctive radiological features, the absence of a pyramidal eminence on CT in a patie... 6/25/2021
Jagmeet Singh, Sushmita Khadka, Dhanshree Solanki, Asim Kichloo, Harshil Shah, Manasee J Vyas, Savneek Chugh, Neil Patel, Shantanu Solanki Pulmonary embolism in chronic kidney disease and end-stage renal disease hospitalizations Trends, outcomes, and predictors of mortality in the United States CONCLUSION: The mortality rate and length of stay in pulmonary embolism patients with chronic kidney disease and end-stage renal disease were significantly higher than those in pulmonary embolism patients with normal kidney function. Also, pulmonary embolism patients with chronic kidney disease and ... 6/23/2021
Ritwik Vatsyayan, Daniel Cleary, Joel R Martin, Eric Halgren, Shadi A Dayeh Electrochemical safety limits for clinical stimulation investigated using depth and strip electrodes in the pig brain Objective. Diagnostic and therapeutic electrical stimulation are increasingly utilized with the rise of neuromodulation devices. However, systematic investigations that depict the practical clinical stimulation paradigms (bipolar, two-electrode configuration) to determine the safety limits are curre... 5/20/2021
Alexander C Constantino, Nathaniel D Sisterson, Naoir Zaher, Alexandra Urban, R Mark Richardson, Vasileios Kokkinos Expert-Level Intracranial Electroencephalogram Ictal Pattern Detection by a Deep Learning Neural Network Background: Decision-making in epilepsy surgery is strongly connected to the interpretation of the intracranial EEG (iEEG). Although deep learning approaches have demonstrated efficiency in processing extracranial EEG, few studies have addressed iEEG seizure detection, in part due to the small numbe... 5/20/2021
Devkishan Chauhan, Yakup Kilic, Jonathan P Segal, Neil Patel, Louis Koizia An Unusual Cause of Gastrointestinal Perforation in an Adolescent Patient With Beta-Thalassemia on Deferasirox and SARS-CoV-2 Infection Chelation therapy is recognized as a safe and effective treatment option in patients with beta-thalassemia with iron overload. We report an 18-year-old male with acute abdomen and gastrointestinal bleeding with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection secondary to gastr... 5/19/2021
Terence Verla, David S Xu, Matthew J Davis, Edward M Reece, Michelle Kelly, Mervin Nunez, Sebastian J Winocour, Alexander E Ropper Failure in Cervical Spinal Fusion and Current Management Modalities Failed fusion in the cervical spine is a multifactorial problem stemming from a combination of patient and surgical factors. Patient-related risk factors such as steroid use, poor bone quality, and smoking can be optimized preoperatively. Age, prior radiation, prior surgery, and underlying genetics ... 5/17/2021
Taylor P Saley, Neil D Patel, Yaniv Bar-Cohen, Michael J Silka, Allison C Hill Utility of Surveillance Ambulatory Rhythm Monitoring in the Pediatric Fontan Population Our institution established a Fontan surveillance plan, which included ambulatory rhythm monitoring (ARM) at 6, 10, 13, 16 and 19 years old, for early detection of Fontan-associated complications. We conducted a retrospective chart review of Fontan patients followed at our institution 2014-2018 to d... 5/8/2021
Robert J Macielak, Jason H Barnes, Jamie J Van Gompel, Brian A Neff, Michael J Link, Colin L Driscoll, Matthew L Carlson, Neil S Patel Degree of preoperative hearing loss predicts time to early mobilization following vestibular schwannoma microsurgery CONCLUSION: Following microsurgical removal of VS, preoperative profound hearing loss was associated with a shorter time to postoperative mobilization; however, there were no observed associations with duration or severity of nystagmus and time to hospital discharge. Although not a predictor of nyst... 4/29/2021
Kenneth A Feder, Marcia Pearlowitz, Alexandra Goode, Monique Duwell, Thelonious W Williams, Ping An Chen-Carrington, Ami Patel, Catherine Dominguez, Eric N Keller, Liore Klein, Alessandra Rivera-Colon, Heba H Mostafa, C Paul Morris, Neil Patel, Anna M Schauer, Robert Myers, David Blythe, Katherine A Feldman Linked Clusters of SARS-CoV-2 Variant B1351 - Maryland, January-February 2021 In late January 2021, a clinical laboratory notified the Maryland Department of Health (MDH) that the SARS-CoV-2 variant of concern B.1.351 had been identified in a specimen collected from a Maryland resident with COVID-19 (1). The SARS-CoV-2 B.1.351 lineage was first identified in South Africa (2) ... 4/29/2021
Vikram Shivkumar, Thyagarajan Subramanian, Pinky Agarwal, Zoltan Mari, Tiago A Mestre, Parkinson Study Group Uptake of telehealth in Parkinsons disease clinical care and research during the COVID-19 pandemic CONCLUSION: The current results suggest a need for flexibility in conducting office visits and clinical trials in PD patients. Technology has the potential to enhance patient care and convenience, when in-person visits can be challenging. 4/25/2021
Alana Aylward, Morganne Murphy-Meyers, Chelsea McCarty Allen, Neil S Patel, Richard K Gurgel Frailty and Quality of Life After Cochlear Implantation in Older Adults CONCLUSIONS: Frailty index does not correlate with hearing scores after cochlear implantation in older adults. Lower frailty index and more improvement in PTA predict better QOL scores after cochlear implantation in older adults. 4/20/2021
Dalya Munves Ferguson, Vikas S Gupta, Pamela A Lally, Matias Luco, KuoJen Tsao, Kevin P Lally, Neil Patel, Matthew T Harting, Congenital Diaphragmatic Hernia Study Group Early, Postnatal Pulmonary Hypertension Severity Predicts Inpatient Outcomes in Congenital Diaphragmatic Hernia INTRODUCTION: Pulmonary hypertension (PH) is the major pathophysiologic consequence of congenital diaphragmatic hernia (CDH). We aimed to evaluate the association between early CDH-associated PH (CDH-PH) and inpatient outcomes. 4/13/2021
Gustavo Vilchez, Komal Kumar, Som Singh, Neil Patel, Monica Kao, Moraima Lagos, Jose Duncan Risk of preterm birth and neonatal outcomes after cerclage placement in triplet pregnancies CONCLUSIONS: Cerclage placement in triplet pregnancies does not appear to decrease preterm birth rates and seems to increase the risk of neonatal complications. 4/13/2021
Edward C Kuan, William P Kennedy, Neil N Patel, Khodayar Goshtasbi, Michael A Kohanski, Charles C L Tong, Peter Papagiannopoulos, David W Kennedy, James N Palmer, Nithin D Adappa, John V Bosso Pre-intervention SNOT-22 scores predict outcomes in aspirin exacerbated respiratory disease CONCLUSION: Preoperative SNOT-22 scores may be used as a predictor of postoperative, post-AD patient-reported outcomes in AERD. Patients with mild and moderate disease may derive benefit from surgery and AD alone, while those with severe disease may require additional interventions (e.g., biologics)... 4/9/2021
Manas Dave, Siobhan Barry, Paul Coulthard, Ron Daniels, Mark Greenwood, Noha Seoudi, Graham Walton, Neil Patel An evaluation of sepsis in dentistry Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. It is a major health concern and causes substantial morbidity and mortality. It is imperative that the signs of sepsis are identified early in both adult and paediatric patients and appropriately esca... 3/27/2021
Vikas S Gupta, Neil Patel, Florian Kipfmueller, Pamela A Lally, Kevin P Lally, Matthew T Harting Elevated proBNP levels are associated with disease severity, cardiac dysfunction, and mortality in congenital diaphragmatic hernia CONCLUSION: Among CDH patients, elevated proBNP was associated with high-risk defects, ventricular dysfunction, and mortality. ProBNP shows promise as a biomarker in CDH-associated cardiac dysfunction. 3/22/2021
Roshan S Prabhu, Brandon E Turner, Anthony L Asher, Samuel R Marcrom, John B Fiveash, Paul M Foreman, Robert H Press, Zachary S Buchwald, Walter J Curran, Kirtesh R Patel, William G Breen, Paul D Brown, Krishan R Jethwa, Inga S Grills, Jessica D Arden, Lauren M Foster, Matthew A Manning, Zachary K Vaslow, Stuart H Burri, Scott G Soltys Leptomeningeal disease and neurologic death after surgical resection and radiosurgery for brain metastases A multi-institutional analysis CONCLUSIONS: LMD after surgery and SRS for brain metastases is a clinically significant event with high rates of ND. Classical LMD pattern (vs. nodular) and second LMD failure after salvage treatment were significantly associated with a higher risk of ND. Patients with nLMD treated with salvage foca... 3/18/2021
Farhan A Shah, Gilad Guez, Neil Patel, Brijesh B Patel Complicated Post-Partum HELLP Syndrome Causing Acute Renal Failure and a Spontaneous Acute Subdural Hematoma HELLP syndrome is characterized by hemolysis, elevated liver enzymes, and thrombocytopenia. It is a devastating illness that typically occurs in the third trimester of gestation. We present a unique case of complicated post-partum HELLP syndrome. The patient was a 34-year-old Caucasian G1PO woman at... 3/17/2021
Sangeeta Prabhakar Bhat, Neil R Patel, Nishant Sethi Successful WATCHMAN Device Placement Despite Left Atrial Appendage Perforation in Two Cases The WATCHMAN (Boston Scientific, Marlborough, USA) is a device used to occlude the left atrial appendage (LAA) in patients of non-valvular atrial fibrillation (NVAF) with a high CHA(2)DS(2)-VASc score who are poor candidates for oral anticoagulation. LAA perforation is a well-known complication of t... 3/15/2021
Pavan S Upadhyayula, Joel R Martin, Robert C Rennert, Joseph D Ciacci Review of operative considerations in spinal cord stem cell therapy Spinal cord injury (SCI) can permanently impair motor and sensory function and has a devastating cost to patients and the United States healthcare system. Stem cell transplantation for treatment of SCI is a new technique aimed at creating biological functional recovery. Operative techniques in stem ... 3/12/2021
Praveen Venkatesh, Daniel Sneider, Mohammed Danish, Nathaniel D Sisterson, Naoir Zaher, Alexandra Urban, Pulkit Grover, R Mark Richardson, Vasileios Kokkinos Quantifying a frequency modulation response biomarker in responsive neurostimulation Objective.Responsive neurostimulation (RNS) is an effective treatment for controlling seizures in patients with drug-resistant focal epilepsy who are not suitable candidates for resection surgery. A lack of tools for detecting and characterizing potential response biomarkers, however, contributes to... 3/10/2021
Neil Patel, Anthony Costa, Stephen P Sanders, David Ezon Stereoscopic virtual reality does not improve knowledge acquisition of congenital heart disease Advances in virtual reality have made it possible for clinicians and trainees to interact with 3D renderings of hearts with congenital heart disease in 3D stereoscopic vision. No study to date has assessed whether this technology improved instruction compared to standard 2D interfaces. The purpose o... 3/7/2021
Samir B Pancholy, Gaurav A Patel, Dhara D Patel, Neil Patel, Shivam A Pancholy, Purveshkumar Patel, Linda Thomas-Hemak, Tejas M Patel, David J Callans Association between insurance status and in-hospital outcomes in patients with out-of-hospital ventricular fibrillation arrest CONCLUSION: Lack of health insurance is associated with higher in-hospital mortality, lower utilization of ICD and higher cost of hospitalization after OHVFA. 3/4/2021
Anna Claudia Massolo, Anita Romiti, Milena Viggiano, Chiara Vassallo, Marie Anne Ledingham, Antonio Lanzone, Leonardo Caforio, Pietro Bagolan, Neil Patel Fetal cardiac dimensions in congenital diaphragmatic hernia relationship with gestational age and postnatal outcomes CONCLUSIONS: LV hypoplasia in CDH is characterized by reduced MVd from 24 weeks GA. MVd, and the ratio of mitral and tricuspid valve diameters at later gestations, may be potential predictors of disease severity. 3/2/2021
Luisa M Recinos, Sonmoon Mohapatra, Aadhithyaraman Santharaman, Neil Patel, Arkady Broder Retroperitoneal Liposarcoma Presenting With Malignant Gastric Outlet Obstruction and Acute Pancreatitis A Case Report Dedifferentiated liposarcomas (DDLPS) are rare, high-grade malignancies that usually originate in the retroperitoneum. Frequently, they present as asymptomatic masses, abdominal distention, abdominal pain, and weight loss. They tend to grow significantly and are usually large in size at the time of ... 2/25/2021
Edward M Reece, Matthew J Davis, Ryan D Wagner, Amjed Abu-Ghname, Alex Cruz, Geoffrey Kaung, Terence Verla, Sebastian Winocour, Alexander E Ropper Vascularized Bone Grafts for Spinal Fusion-Part 1 The Iliac Crest CONCLUSION: While long-term follow-up will be required to fully characterize fusion rates and patient morbidity, this innovative surgical option augments spinal fusion in patients with, or at increased risk for, pseudoarthrosis. 2/22/2021
Bryndan W Lindsey, Ali Boolani, Justin J Merrigan, Nelson Cortes, Shane V Caswell, Joel R Martin Relationship Between Employment Status, Reported Physical Activity, and Sitting Time During COVID-19 Pandemic CONCLUSIONS: Employment status was not related to physical activity; however, it did affect the amount of time spent sitting, with nonessential employees sitting more and working more hours than essential employees. Because greater amounts of daily total sitting time have been associated with increa... 2/18/2021
Jessica Ford, Greta Bushnell, Ashley M Griffith, Golsa Joodi, Ankita Ashoka, Neil Patel, Mariya Husain, Irion W Pursell, Samuel F Sears, John Paul Mounsey, Ross J Simpson Mental Disorders, Substance Use Disorders, and Psychotropic Medication Use Among Sudden-Death Victims CONCLUSIONS: Mental illness, substance use disorders, and psychotropic medication prescriptions were prevalent among sudden-death victims. The health care needs of these individuals may be better addressed by collaborative care for general medical and mental disorders. 2/17/2021
Adrian Mancini, Vincent Vangelder, Robert Caiazzo, Camille Marciniak, Naïma Oukhouya Daoud, Neil Patel, François Pattou, Grégory Baud Salvage Robotic Roux-en-Y Fistulojejunostomy for Chronic Gastro-Colic Fistula After Laparoscopic Sleeve Gastrectomy Roux-en-Y fistulojejunostomy (RYFJ) has been proposed as a surgical option for the treatment of a chronic fistula after sleeve gastrectomy but can be technically challenging. The robotic approach in bariatric surgery has emerged as a new rapidly evolving technology and allows performing more complex... 2/16/2021
Anna C Massolo, Maria Clemente, Neil Patel, Giulia V Cantone, Alessandra Toscano, Benjamim Ficial, Francesca Landolfo, Flaminia Calzolari, Irma Capolupo, Paolo Biban, Andrea Dotta Could myocardial function be predictive of successful extubation in newborns and infants OBJECTIVE: To investigate the relationship between cardiac function and extubation readiness in infants using speckle tracking echocardiography. 2/13/2021
Karolina A Plonowska, Edgar Ochoa, Aaron L Zebolsky, Neil Patel, Kathryn R Hoppe, Patrick K Ha, Chase M Heaton, William R Ryan Nasogastric tube feeding after transoral robotic surgery for oropharynx carcinoma CONCLUSIONS: A majority of patients undergoing TORS do not need NGTF. When NGTF is needed, the duration of use is usually longer than 14 days. Larger tumor size and concurrent bilateral ND are risk factors for NGTF. 1/29/2021
Jason H Barnes, Neil S Patel, Christine M Lohse, Nicole M Tombers, Michael J Link, Matthew L Carlson Impact of Treatment on Vestibular Schwannoma-Associated Symptoms A Prospective Study Comparing Treatment Modalities CONCLUSIONS: Limited prospective data exist regarding the progression or resolution of subjective symptoms in those presenting with VS. This study suggests that tinnitus, dizziness or imbalance, and headaches are unlikely to be significantly modified by treatment modality and generally should not be... 1/26/2021
Shunumuga S Ponnusamy, Neil R Patel, Angela Naperkowski, Faiz A Subzposh, Pugazhendhi Vijayaraman Cardiac troponin release following left bundle branch pacing Left bundle branch pacing (LBBP) has emerged as an alternative to His bundle pacing (HBP) to achieve physiologic ventricular stimulation. The extent of myocardial injury during permanent LBBP implantation is currently not known. The aim of the study was to prospectively assess the extent of myocardi... 1/23/2021
Emanuele Orru', Miklos Marosfoi, Neil V Patel, Alexander L Coon, Christoph Wald, Nicholas Repucci, Patrick Nicholson, Vitor M Pereira, Ajay K Wakhloo International teleproctoring in neurointerventional surgery and its potential impact on clinical trials in the era of COVID-19 legal and technical considerations CONCLUSIONS: International teleproctoring was successfully implemented in our clinical practice. Its first use provided important insights for establishing this tool in our field. With no clear horizon for lifting the current travel restrictions, teleproctoring has the potential to remove the need f... 1/14/2021
Lorenzo Rinaldo, Neil S Patel, Colin L W Driscoll, Michael J Link Anterior Petrosal Approach for Enlarging Previously Radiated Recurrent Trigeminal Schwannoma 2-Dimensional Operative Video Trigeminal nerve schwannomas (TNSs) are rare lesions that typically present with symptoms of trigeminal neuropathy or other cranial nerve palsies. These lesions classically have a dumbbell shape, with an anterior component within Meckel's cave and posterior component extending into the posterior fos... 1/13/2021
Louise Dunphy, Ambika Talwar, Neil Patel, Alex Evans Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations Hereditary haemorrhagic telangiectasia (HHT) also known as Osler-Weber-Rendu syndrome is an autosomal dominant disorder affecting 1 in 8000 individuals. The eponym recognises the 19th-century physicians William Osler, Henri Jules Louis Marie Rendu and Frederick Parkes Weber who each independently de... 1/9/2021
Dipali Nemade, Mitzi Beckett, Justin Nolte, Vikram Shivkumar Make Kids Stroke-Smart A Community Based Interventional Study CONCLUSION: Targeting the younger generation for stroke education is one way to improve community knowledge of stroke symptoms thus increasing the chances that the stroke patient may receive acute stroke therapy. Children can also be used as a conduit to transmit educational information to parents a... 1/8/2021
Justin J Merrigan, Adam A Burke, Marcie B Fyock-Martin, Joel R Martin What Factors Predict Upper Body Push to Pull Ratios in Professional Firefighters Shoulder joint injuries are common for professional firefighters. A potential cause of shoulder injury is an imbalance between anterior (push) and posterior (pull) shoulder joint musculature. Understanding what contributes to these imbalances may help to identify areas needing improvement. The purpo... 1/8/2021
Neil R Patel, Sangeeta Prabhakar Bhat, Shantanu Solanki, Terry Bauch, Yassir Nawaz Coronary Steal in a Patient With Apical Hypertrophic Cardiomyopathy A Rare Case of Symptomatic Coronary Artery Fistula This report describes a rare case of multiple left coronary artery to pulmonary artery/left atrial fistulae causing a coronary steal phenomenon. A 58-year-old male with apical hypertrophic cardiomyopathy was seen in an outpatient office for exertional chest pain and dyspnea and subsequently had a po... 1/7/2021
Samir B Pancholy, Gaurav A Patel, Neil R Patel, Dhara D Patel, Purveshkumar Patel, Stuti M Pandya, Anshul A Verma, Sanjay C Shah, Mamas A Mamas, Tejas M Patel Trends, Outcomes, and Predictive Score For Emergency Coronary Artery Bypass Graft Surgery After Elective Percutaneous Coronary Intervention from a Nationwide Dataset The temporal trends and preprocedural predictors of emergency coronary artery bypass graft surgery (ECABG) after elective percutaneous coronary intervention (PCI) in the contemporary era are largely unknown. From January 2003 to December 2014 elective hospitalizations with PCI as the primary procedu... 1/1/2021
Neil N Patel, Ivy W Maina, Edward C Kuan, Vasiliki Triantafillou, Michal A Trope, Ryan M Carey, Alan D Workman, Charles C Tong, Michael A Kohanski, James N Palmer, Nithin D Adappa, Jason G Newman, Jason A Brant Adenocarcinoma of the Sinonasal Tract A Review of the National Cancer Database Background Sinonasal adenocarcinoma (SNAC) is a rare malignancy arising from mucus-secreting glandular tissue. Limited large-scale studies are available due to its rarity. We evaluated SNAC in the National Cancer Database (NCDB), a source that affords multi-institutional, population studies of rare ... 12/31/2020
Robert C Rennert, Michael G Brandel, Jeffrey A Steinberg, Joel R Martin, David D Gonda, Takanori Fukushima, John D Day, Alexander A Khalessi, Michael L Levy Surgical Relevance of Pediatric Anterior Clinoid Process Maturation for Anterior Skull Base Approaches CONCLUSION: The ACP demonstrates stable thickness and a complex triphasic elongation and remodeling pattern with development, the understanding of which may facilitate removal in patients <12. Clinically relevant ACP anatomic variations can occur at any age. 12/29/2020
Terence Verla, Venita Simpson, Alexander E Ropper Solitary Fibrous tumor of the lumbar spine mimicking a sequestered disc fragment Solitary fibrous tumor in the lumbar spine is a rare pathology with non-specific radiographic features, sometimes resulting in misdiagnosis. Our patient was a 41-year old female who presented with low back pain and bilateral leg pain. Initial MRI showed a lesion misdiagnosed for a sequestered disc a... 12/28/2020
Justin J Merrigan, Joel R Martin Is the OUTPUT Sports Unit Reliable and Valid When Estimating Back Squat and Bench Press Concentric Velocity Merrigan, JJ and Martin, JR. Is the OUTPUT sports unit reliable and valid when estimating back squat and bench press concentric velocity? J Strength Cond Res 36(8): 2069-2076, 2022-This study evaluated the reliability and concurrent validity of the OUTPUT sports inertial unit to measure concentric v... 12/18/2020
Anna Dargue, Eithne Fyfe, Kathryn French, Kamran Ali, Edmund Bailey, Aileen Bell, Robert Bolt, Yogesh Bulsara, James Carey, Charlotte Emanuel, Rachel Green, Nadine Khawaja, Evgeny Kushnerev, Neil Patel, Simon Shepherd, Binthan Smart, Joanna Smyth, Kate Taylor, Kumar Varma Datla The impact of wrong-site surgery on dental undergraduate teaching a survey of UK dental schools CONCLUSION: UK dental schools have increased the emphasis on patient safety by the implementation of national healthcare models, for example WHO checklists and pre-operative briefings. These strategies both aim to improve communication and teamwork. Increased levels of staff supervision foster great... 12/14/2020
Sushmita Khadka, Dhanshree Solanki, Jagmeet Singh, Asim Kichloo, Neil R Patel, Purnima Sharma, Savneek Chugh, Shantanu Solanki Trends and outcomes of venous thromboembolism in adult hospitalizations with acute myeloid leukemia analysis of nationwide inpatient sample from 2010 to 2014 Background: Venous thromboembolism (VTE) occurs frequently in acute myeloid leukemia (AML) patients. There are no population-based studies from the United States (U.S.) analyzing this association. The study aims to analyze the trends, predictors of mortality, and outcomes of VTE in AML patients.Meth... 12/11/2020
Santokh S Tandon, Neil Patel, Scott D Bunge, Esther C Wang, Rachel Thompson, Laurence K Thompson One-Pot Self-Assembly of Dinuclear, Tetranuclear, and H-Bonding-Directed Polynuclear CobaltII, CobaltIII, and Mixed-Valence CoIICoIII Complexes of Schiff Base Ligands with Incomplete Double Cubane Core The reaction of 2,6-diformyl-4-methylphenol (DFMF) with 1-amino-2-propanol (AP) and tris(hydroxymethyl)aminomethane (THMAM) was investigated in the presence of Cobalt(II) salts, (X = ClO(4)^(-), CH(3)CO(2)^(-), Cl^(-), NO(3)^(-)), sodium azide (NaN(3)), and triethylamine (TEA). In one pot, the varia... 12/2/2020
Santokh S Tandon, Scott D Bunge, Neil Patel, Esther C Wang, Laurence K Thompson Self-Assembly of Antiferromagnetically-Coupled CopperII Supramolecular Architectures with Diverse Structural Complexities The self-assembly of 2,6-diformyl-4-methylphenol (DFMP) and 1-amino-2-propanol (AP)/2-amino-1,3-propanediol (APD) in the presence of copper(II) ions results in the formation of six new supramolecular architectures containing two versatile double Schiff base ligands (H(3)L and H(5)L1) with one-, two-... 12/1/2020
Kamal Kishore, Daniel S McGowan, Tulika Chatterjee, Bahareh Hassanzadeh A Case of Bilateral Endogenous emCandida dubliniensisem Endophthalmitis Treated with Aggressive Local and Systemic Therapy Candida dubliniensis is an emerging pathogen implicated in a variety of infections in immunocompromised hosts. A 79-year-old male with autoimmune pancytopenia on chronic oral steroid therapy was admitted for suspected sepsis and started on empirical antibiotics and micafungin. He developed floaters ... 11/30/2020
Tiffany T Pham, Anna M Stokolosa, Pamela A Borden, Kyle D Hansen, Ellen M Hong, Tatiana B Krasieva, Ryan H Sivoraphonh, Wesley J Moy, Andrew E Heidari, Lauren H Lee, Eun-Hee Kim, Chung- Ho Sun, Wangcun Jia, Ji -Hun Mo, Sehwan Kim, Michael G Hill, Brian J F Wong Electrochemical degradation and saponification of porcine adipose tissue Body contouring achieved via subcutaneous adipose tissue reduction has notably advanced over the past century, from suction assisted lipectomy to techniques with reduced degrees of invasiveness including laser, radiofrequency, high frequency focused ultrasound, cryolipolysis, and drug-based injectio... 11/28/2020
Neil D Patel, Connie Friedman, Cynthia Herrington, John C Wood, Andrew L Cheng Progression in Fontan conduit stenosis and hemodynamic impact during childhood and adolescence CONCLUSIONS: Fontan conduit CSA decreases as early as 6 months post-Fontan. The minimum Fontan CSA/BSA was not associated with cardiac index or pulmonary artery size but did correlate with % predicted peak oxygen consumption. 11/22/2020
Arfon Powell, Mubashir Mulla, Catherine Eley, Neil Patel, Tarig Abdelrahman, Paul Blake, Rachael Barlow, Damian Bailey, Wyn Lewis Prognostic significance of low muscle volume in patients undergoing surgery for oesophageal cancer CONCLUSION: BIA is an important prognostic indicator in OC and focused pre-habilitation consequently has strong potential. 11/13/2020
Naoir Zaher, Alexandra Urban, Arun Antony, Cheryl Plummer, Anto Bagić, R Mark Richardson, Vasileios Kokkinos Ictal Onset Signatures Predict Favorable Outcomes of Laser Thermal Ablation for Mesial Temporal Lobe Epilepsy Background: Laser interstitial thermal therapy (LiTT) has emerged as a minimally invasive option for surgical treatment of refractory epilepsy. However, LiTT of the mesial temporal (MT) structures is still inferior to anterior temporal lobectomy (ATL) in terms of postoperative outcome. In this pilot... 11/12/2020
Matthew L Carlson, Jason H Barnes, Ashley Nassiri, Neil S Patel, Nicole M Tombers, Christine M Lohse, Jamie J Van Gompel, Brian A Neff, Colin L W Driscoll, Michael J Link Prospective Study of Disease-Specific Quality-of-Life in Sporadic Vestibular Schwannoma Comparing Observation, Radiosurgery, and Microsurgery CONCLUSIONS: In this prospective longitudinal study investigating differences in QOL outcomes among VS treatment groups using the disease-specific PANQOL instrument, treatment did not modify QOL in most domains. Microsurgery may confer an advantage with regard to patient anxiety, presumably relating... 11/12/2020
Michel M Sun, Nicolas Seleme, John J Chen, Anastasia Zekeridou, Elia Sechi, Ryan D Walsh, Johanna D Beebe, Osama Sabbagh, Luis J Mejico, Sean Gratton, Philip M Skidd, David A Bellows, Julie Falardeau, Clare L Fraser, Cecilia Cappelen-Smith, Scott R Haines, Bahareh Hassanzadeh, Meagan D Seay, Prem S Subramanian, Zoë Williams, Lynn K Gordon Neuro-Ophthalmic Complications in Patients Treated With CTLA-4 and PD-1PD-L1 Checkpoint Blockade CONCLUSION: This study describes the variable neuro-ophthalmic adverse events associated with use of immune checkpoint inhibitors and contributes a more thorough understanding of their clinical presentations and treatment outcomes. We expect this will increase awareness of these drug complications a... 11/2/2020
Ollie Yiru Yu, Ahmed Mohamed Zaeneldin, Hamdi Hosni Hamda Hamama, May Lei Mei, Neil Patel, Chun-Hung Chu Conservative Composite Resin Restoration for Proximal Caries - Two Case Reports The paradigms of contemporary caries management have shifted to minimal intervention dentistry. Conservative restorative procedures are recommended to replace the complete removal of all carious tissues in the management of dental caries. This article reports two clinical cases of conservative resto... 10/29/2020
Rym El Khoury, Andrew P Russeau, Neil Patel, Firas Dabbous, Irina Kechker, Sergey Lipatov, Timur Ostrovski, Chad E Jacobs, John V White, Lewis B Schwartz Reliability of preoperative venous mapping ultrasonography in predicting for autogenous arteriovenous fistula maturation CONCLUSIONS: Despite the national fistula-first initiatives, most patients still undergo access via catheter at the initiation of hemodialysis. The use of routine preoperative venous mapping does not predict successful primary maturation. Also, no clinically useful predictor of fistula maturation wa... 10/22/2020
Wanda L Fussell, Neil S Patel, Matthew L Carlson, Brian A Neff, Robert E Watson, John I Lane, Colin L W Driscoll Cochlear Implants and Magnetic Resonance Imaging Experience With Over 100 Studies Performed With Magnets in Place CONCLUSIONS: MRI with CI or ABI magnets in place is associated with a low prevalence of adverse events when performed in a controlled setting. Many partial magnet displacements can be corrected with firm manual pressure. Devices with magnets that align with the field within their housing were not as... 10/12/2020
Daniel Shookster, Bryndan Lindsey, Nelson Cortes, Joel R Martin Accuracy of Commonly Used Age-Predicted Maximal Heart Rate Equations Age-predicted maximal heart rate (APMHR) is an essential measure for healthcare professionals in determining cardiovascular response to exercise testing, exertion, and prescription. Although multiple APMHR prediction equations have been validated for specific populations, the accuracy of each within... 10/12/2020
L Savannah Dewberry, Alexander B Dru, Maxwell Gravenstine, Brian Nguyen, James Anderson, Sasha Vaziri, Daniel J Hoh, Kyle D Allen, Kevin J Otto Partial high frequency nerve block decreases neuropathic signaling following chronic sciatic nerve constriction injury Objective.High frequency (HF) block can quickly and reversibly stop nerve conduction. We hypothesized HF block at the sciatic nerve would minimize nociception by preventing neuropathic signals from reaching the central nervous system.Approach.Lewis rats were implanted with a constriction cuff and a ... 10/7/2020
Terence Verla, Robert North, Venita Simpson, Alexander E Ropper Osteomyelitis-Discitis at the Thoracolumbar Junction and the Development of Postinfectious Spinal Deformity A Surgical Case Series CONCLUSIONS: Given the proclivity for kyphotic deformity at the TL junction, patients may benefit from long segment instrumentation in addition to decompression at the initial surgery. Laminectomy alone may hasten kyphosis progression. 9/28/2020
Michael Chang, Jose A Canseco, Kristen J Nicholson, Neil Patel, Alexander R Vaccaro The Role of Machine Learning in Spine Surgery The Future Is Now The recent influx of machine learning centered investigations in the spine surgery literature has led to increased enthusiasm as to the prospect of using artificial intelligence to create clinical decision support tools, optimize postoperative outcomes, and improve technologies used in the operating... 9/25/2020
Pavan S Upadhyayula, Robert C Rennert, Joel R Martin, John K Yue, Jason Yang, Eva M Gillis-Buck, Nikki Sidhu, Christopher K Cheung, Anthony T Lee, Reid R Hoshide, Joseph D Ciacci Basal impulses findings from the last twenty years on impulsivity and reward pathways using deep brain stimulation CONCLUSIONS: As newer, more refined DBS technology emerges, large-scale prospective studies specifically aimed at treatment of impulsivity disorders are needed. 9/25/2020
Sandy Kirolos, Lynsey Sutcliffe, Maria Giatsi Clausen, Carolyn Abernethy, Shanthi Shanmugalingam, Nicole Bauwens, Judith Orme, Kirsty Thomson, Rosemary Grattan, Neil Patel Asynchronous video messaging promotes family involvement and mitigates separation in neonatal care CONCLUSIONS: Asynchronous video messaging improves parental experience, emotional closeness to their baby and builds supportive relationships between families and staff. Asynchronous video supports models of family integrated care and can mitigate family separation, which could be particularly relev... 9/15/2020
Robert A Hirschl, Adam H Biedrzycki, Harmanjit S Sidhu, Aaron S Wagner, Virgilio Matheus, Sean T Meiner, Paul M Foreman Static Magnetic Fields within Spinal Interbody Cages for the Promotion of Spinal Arthrodesis A Pilot Study CONCLUSIONS: A spinal interbody cage containing a neodymium iron boron magnet for the production of a local SMF is feasible. Preliminary data suggests enhanced bone formation, bone density, and osseointegration of the graft. 9/6/2020
Shunsuke Aoi, Bora Toklu, Naoki Misumida, Neil Patel, Wonkyoung Lee, John Fox, Hitoshi Matsuo, Yumiko Kanei Effect of Sex Difference on Discordance Between Instantaneous Wave-Free Ratio and Fractional Flow Reserve CONCLUSIONS: Despite similar prevalence of overall concordance and discordance between men and women, iFR+/FFR- discordance was higher in women and iFR-/FFR+ discordance was higher in men. Multivariable analysis showed female sex to be independent predictor of iFR+/FFR- discordance. 8/26/2020
Joel R Martin, Paolo G Gabriel, Jeffrey J Gold, Richard Haas, Suzanne L Davis, David D Gonda, Cynthia Sharpe, Scott B Wilson, Nicolas C Nierenberg, Mark L Scheuer, Sonya G Wang Optical Flow Estimation Improves Automated Seizure Detection in Neonatal EEG CONCLUSIONS: This work presents a novel approach to improving automated seizure detection algorithms used during neonatal video EEG monitoring. This artifact detection mechanism can improve the ability of a seizure detector algorithm to distinguish between artifact and true seizure activity. 8/19/2020
Aniket A Saoji, Weston J Adkins, Amy P Olund, Madison Graham, Neil S Patel, Brian A Neff, Matthew L Carlson, Colin L W Driscoll Increase in cochlear implant electrode impedances with the use of electrical stimulation CONCLUSION: In this study, we report two cases of electrode impedances increasing as a function of device use. Numerous management strategies were employed to reduce this effect but none prevailed; a clear pathophysiologic mechanism remains elusive. Further study into the cause of this electrode imp... 8/5/2020
James Mooney, Adeel Ilyas, Sheela Vivekanandan, Reginald Fong, Bonita S Agee, Mamerhi O Okor, Kristen O Riley, Sean T Meiner, Christoph J Griessenauer, Paul M Foreman Anticoagulant Medications and Operative Subdural Hematomas A Retrospective Cohort Study Evaluating Reoperation Rates CONCLUSIONS: Anticoagulant use was not associated with an increased reoperation rate, suggesting that reversal of AC may have eliminated the hemorrhagic risk conferred by these medications. Patients on ACs were significantly older, harbored more medical comorbidities, and had a worse functional outc... 7/26/2020
Terence Verla, Marc Prablek, Alexander E Ropper, David S Xu, Michael Raber Congenital Fusion of Dens to T3 Vertebra in Klippel-Feil Syndrome CONCLUSION: This is the first reported case of Klippel-Feil syndrome with fusion of all cervical vertebrae down to T3. We recommend surgery for advanced cases of myelopathy or radiculopathy due to stenosis and spinal instability. 7/12/2020
Christoph J Griessenauer, Alejandro Enriquez-Marulanda, Philipp Taussky, Arundhati Biswas, Ramesh Grandhi, Sissi Xiang, Tao Hong, Lorenzo Rinaldo, Giuseppe Lanzino, Waleed Brinjikji, Jan-Karl Burkhardt, Peter Kan, Mandeep Ghuman, Victor X D Yang, Karen Chen, Mohammad A Aziz-Sultan, Mohammad Ghorbani, Clemens M Schirmer, Oded Goren, Shamsher S Dalal, Monika Killer-Oberpfalzer, Erasmia Müller-Thies-Broussalis, Matthew J Koch, Christopher J Stapleton, Aman B Patel, Paul M Foreman, Marshall C Cress, Robert A Hirschl, Timo Krings, Hongqi Zhang, Adam A Dmytriw Experience With the Pipeline Embolization Device for Posterior Circulations Aneurysms A Multicenter Cohort Study CONCLUSION: This multicenter study shows that PED for the treatment of posterior circulation is preferentially used for the treatment of fusiform and dissecting/blister aneurysm morphologies. Despite the challenges presented by these less-common morphologies, flow diversion may be performed with a n... 7/7/2020
Christoph J Griessenauer, Alejandro Enriquez-Marulanda, Sissi Xiang, Tao Hong, Hongqi Zhang, Philipp Taussky, Ramesh Grandhi, Muhammad Waqas, Vincent M Tutino, Adnan H Siddiqui, Elad I Levy, Christopher S Ogilvy, Ajith J Thomas, Christian Ulfert, Markus A Möhlenbruch, Leonardo Renieri, Nicola Limbucci, Carmen Parra-Fariñas, Jan-Karl Burkhardt, Peter Kan, Lorenzo Rinaldo, Giuseppe Lanzino, Waleed Brinjikji, Julian Spears, Erasmia Müller-Thies-Broussalis, Monika Killer-Oberpfalzer, Civan Islak, Naci Kocer, Michael Sonnberger, Tobias Engelhorn, Mandeep Ghuman, Victor Xd Yang, Arsalaan Salehani, Mark R Harrigan, Ivan Radovanovic, Vitor M Pereira, Timo Krings, Charles C Matouk, Karen Chen, Mohammad Ali Aziz-Sultan, Mohammad Ghorbani, Clemens M Schirmer, Oded Goren, Shamsher S Dalal, Matthew J Koch, Christopher J Stapleton, Aman B Patel, Thomas Finkenzeller, Markus Holtmannspötter, Jan Hendrik Buhk, Paul Michael Foreman, Marshall Cress, Robert Hirschl, Wolfgang Reith, Andreas Simgen, Hendrik Janssen, Thomas R Marotta, Adam A Dmytriw Comparison of PED and FRED flow diverters for posterior circulation aneurysms a propensity score matched cohort study CONCLUSION: Comparative analysis of PED and FRED for the treatment of unruptured posterior circulation aneurysms did not identify significant differences in aneurysm occlusion or neurologic complications. Variations in functional outcomes warrant additional investigations. 7/3/2020
Amit K J Mandal, Neil B Patel, Constantinos G Missouris Sepsis Unmasking Fahrs Disease Fahr's disease is a sporadic or familial neurodegenerative disorder characterized by symmetrical calcification of cerebral structures, particularly the basal ganglia, cerebellar dentate nuclei and surrounding white matter, in the absence of metabolic causes of calcification. We report the case of a ... 6/29/2020
Louise Dunphy, Neil Patel, Bret Palmer, Edward McKeown Missed opportunity to diagnose HIV with emPneumocystis cariniiem pneumonia as its sequela Pneumocystis carinii pneumonia (PCP) is an opportunistic infection of the lung occurring primarily in patients with HIV infection with a CD4 cell count <200 mm³, solid organ transplant recipients and those taking immunosuppressive therapy. The 1980s heralded the HIV pandemic, turning PCP into a majo... 6/27/2020
Cathryn Draicchio, Joel R Martin, Marcie B Fyock-Martin, Justin J Merrigan Retrospective Cohort Analysis of the Army Physical Fitness Test and the Occupational Physical Assessment Test in Reserve Officer Training Corps Cadets A Brief Report CONCLUSIONS: Sex differences and varied relationships among individual events on two common military fitness test batteries were observed. Lower performances on APFT and OPAT by women may suggest the need to evaluate potential training methods to assist women in reaching their desired MOS. Further, ... 5/29/2020
Andree H Koop, Jed Cowdell, Neej Patel, Alex Kesler, Edson Mwakyanjala, Alexander Heckman, Divya Padmanabhan Menon, Neil Patel, Patricia Narciso, Ashley Reid, Nicholl Decicco, Leigh Speicher Intravenous Access in Gastrointestinal Hemorrhage A Multidisciplinary Quality Improvement Initiative Led by Emergency Department Nurses and Internal Medicine Physicians CONCLUSIONS: Carefully directed education of ED physicians and nurses with monthly feedback was effective in improving appropriate intravenous placement in patients with GIH. 5/21/2020
Katrin Heindel, Stefan Holdenrieder, Neil Patel, Peter Bartmann, Lukas Schroeder, Christoph Berg, Waltraut Maria Merz, Andreas Mueller, Florian Kipfmueller Early postnatal changes of circulating N-terminal-pro-B-type natriuretic peptide in neonates with congenital diaphragmatic hernia CONCLUSION: NT-proBNP analysis in the first 48 h of life may be useful to assess PH and cardiac dysfunction in CDH newborns and to predict the need for ECMO support. 5/14/2020
Ross Bogle, Rachel McIntyre, Neil Patel, Timothy John Bradnock Deprivation increases perforation risk in paediatric appendicitis Acute appendicitis is the most common surgical emergency in childhood. Perforation of the appendix conveys a worse outcome.This case-control study investigated the relationship between deprivation and appendiceal perforation in children in the West of Scotland.All children undergoing acute appendice... 4/29/2020
Paul M Foreman, Mirja M Wirtz, Reginald Fong, Oded Goren, Clemens M Schirmer, Shamsher Dalal, Gregory Weiner, Christoph J Griessenauer The Utility of a Diagnostic Angiogram Following Mechanical Thrombectomy for Treatment of Acute Ischemic Stroke CONCLUSION: Angiographic imaging of non-target vessels following mechanical thrombectomy identified previously unknown vascular pathology in 4.4% of procedures and resulted in a clinical management change in 3.3% of cases. 4/24/2020
Marcie B Fyock-Martin, Eric K Erickson, Allan H Hautz, Katie M Sell, Bradley L Turnbaugh, Shane V Caswell, Joel R Martin What do Firefighting Ability Tests Tell Us About Firefighter Physical Fitness A Systematic Review of the Current Evidence Fyock-Martin, MB, Erickson, EK, Hautz, AH, Sell, KM, Turnbaugh, BL, Caswell, SV, and Martin, JR. What do firefighting ability tests tell us about firefighter physical fitness? A systematic review of the current evidence. J Strength Cond Res 34(7): 2093-2103, 2020-The firefighting profession is a phy... 4/15/2020
Ganne Chaitanya, Andrew K Romeo, Adeel Ilyas, Auriana Irannejad, Emilia Toth, Galal Elsayed, J Nicole Bentley, Kristen O Riley, Sandipan Pati Robot-assisted stereoelectroencephalography exploration of the limbic thalamus in human focal epilepsy implantation technique and complications in the first 24 patients CONCLUSIONS: Using judiciously planned robot-assisted SEEG, the authors demonstrate the safety of electrophysiological sampling from various thalamic nuclei for research recordings, presenting a technique that avoids implanting additional depth electrodes or compromising clinical care. With these re... 4/3/2020
Terence Verla, Eric Goethe, Visish M Srinivasan, Lona Winnegan, Ibrahim Omeis The minimally invasive paramedian approach for foraminal disc herniation Foraminal disc herniation presents with an operative challenge, as it often requires facetectomy, which can result in segmental instability. The intraforaminal approach includes partial pars resection and medial facetectomy and allows for direct visualization of the nerve roots and herniated disc in... 4/1/2020
Wendy Edlund, Neil Patel, David DeLone, Suresh Kotagal Intracranial Epidural Abscess in a 9-Year-Old Boy With Precocious Puberty and Use of Continuous Positive Airway Pressure Intracranial extension of rhinosinusitis is rare in children. We report a 9-year-old immunocompetent boy with central precocious puberty and obstructive sleep apnea-hypopnea syndrome who developed an intracranial epidural abscess secondary to rhinosinusitis while on continuous positive airway pressu... 4/1/2020
Adam A Dmytriw, Anish Kapadia, Alejandro Enriquez-Marulanda, Carmen Parra-Fariñas, Anna Luisa Kühn, Patrick J Nicholson, Muhammad Waqas, Leonardo Renieri, Caterina Michelozzi, Paul M Foreman, Kevin Phan, I-Hsiao Yang, Vincent M Tutino, Christopher S Ogilvy, Ivan Radovanovic, Mark R Harrigan, Adnan H Siddiqui, Elad I Levy, Nicola Limbucci, Christophe Cognard, Timo Krings, Vitor Mendes Pereira, Ajith J Thomas, Thomas R Marotta, Christoph J Griessenauer Vertebral artery aneurysms and the risk of cord infarction following spinal artery coverage during flow diversion CONCLUSIONS: FD aneurysm treatment in the posterior circulation with coverage of ASA or PSA/LSA was not associated with higher rates of occlusion of these branches or any instances of cord infarction. 3/29/2020
Neil D Patel, Stephen Nageotte, Frank F Ing, Aimee K Armstrong, Ramen Chmait, Jon A Detterich, Alberto Galindo, Helena Gardiner, Sofia Grinenco, Ulrike Herberg, Edgar Jaeggi, Shaine A Morris, Dick Oepkes, John M Simpson, Anita Moon-Grady, Jay D Pruetz Procedural, pregnancy, and short-term outcomes after fetal aortic valvuloplasty CONCLUSIONS: FAV is an often successful but high-risk procedure. Multiple cardiac punctures are associated with increased complication and fetal mortality rates. Later GA at intervention and technical success were independently associated with increased odds of live birth. However, performing the pr... 3/28/2020
Ryan M Carey, Edward C Kuan, Alan D Workman, Neil N Patel, Michael A Kohanski, Charles C L Tong, Jinbo Chen, James N Palmer, Nithin D Adappa, Jason A Brant A Population-Level Analysis of Pituitary Carcinoma from the National Cancer Database Objectives Pituitary carcinoma is a rare entity with fewer than 200 total cases reported in the English literature. Analysis of the population-level data from the National Cancer Database (NCDB) affords the opportunity to study this poorly understood tumor type. Methods The NCDB was queried for site... 3/25/2020
Tiffany T Pham, Ellen M Hong, Wesley J Moy, Jiayi Zhao, Allison C Hu, Christian H Barnes, Pamela A Borden, Ryan Sivoraphonh, Tatiana B Krasieva, Lauren H Lee, Andrew E Heidari, Eun Hee Kim, Sang Hyun Nam, Wangcun Jia, Ji-Hun Mo, Sehwan Kim, Michael G Hill, Brian J F Wong The biophysical effects of localized electrochemical therapy on porcine skin CONCLUSION: We demonstrated the production of in situ acid and base in skin occurring via ECT. The effects chemically and precisely alter collagen structure through denaturation, giving insight on the potential of ECT as a simple, low-cost, and minimally-invasive means to remodel skin and treat scar... 3/15/2020
Duy T Dao, Neil Patel, Matthew T Harting, Kevin P Lally, Pamela A Lally, Terry L Buchmiller Early Left Ventricular Dysfunction and Severe Pulmonary Hypertension Predict Adverse Outcomes in Low-Risk Congenital Diaphragmatic Hernia CONCLUSIONS: Early left ventricular dysfunction and severe pulmonary hypertension are independent predictors of adverse outcomes among "low-risk" congenital diaphragmatic hernia infants. Early recognition may lead to interventions that can improve outcome in this at-risk cohort. 3/14/2020
Dipali Nemade, Vikram Shivkumar, Paul Ferguson, Jaysingh Singh, Sona Shah Psychosocial and Physiologic Characteristics of Patients with Non-epileptic Events A Retrospective Study Background The main focus of this study is to aid early identification of psychogenic non-epileptic seizure (PNES) patients by identifying physical and psychosocial characteristics to reduce the health care burden, to reduce the unnecessary use of anti-epileptic medications and their side effects, a... 3/7/2020
Anna Claudia Massolo, Giulia Vanina Cantone, Anna Maria Caterina Musolino, Iuri Corsini, Neil Patel, Melania Evangelisti, Francesca Monaco, Maria Pia Villa, Annabella Braguglia Myocardial strain on admission predicts disease severity in infants hospitalized for bronchiolitis CONCLUSIONS: Bronchiolitis is associated with myocardial impairment. Cardiac function is related to disease severity and outcome. 3/6/2020
Mohamed M Salem, Krishnan Ravindran, Alejandro Enriquez-Marulanda, Luis C Ascanio, Noah Jordan, Santiago Gomez-Paz, Paul M Foreman, Christopher S Ogilvy, Ajith J Thomas, Justin M Moore Pipeline Embolization Device Versus Stent-Assisted Coiling for Intracranial Aneurysm Treatment A Retrospective Propensity Score-Matched Study CONCLUSION: PED placement and SAC offer equally efficacious occlusion rates, functional outcomes, procedural complication rates, and cost profiles for small unruptured anterior circulation saccular aneurysms which do not involve the anterior communicating artery. 3/6/2020
Neil B Patel, Cody Blazek, Rick Scanlan, Jeffrey M Manway, Patrick R Burns Common Pitfalls in Subtalar Joint Preparation for Arthrodesis via Sinus Tarsi Approach This cadaveric study assessed factors that could lead to nonunions in subtalar joint arthrodesis. The purpose of this study was to assist surgeons in achieving sufficient joint preparation in hopes to achieve more frequent arthrodesis of the subtalar joint. We evaluated the influence of experience i... 3/5/2020
Louise N Slope, Michael G Hill, Catherine F Smith, Paul Teare, Felicity J de Cogan, Melanie M Britton, Anna F A Peacock Tuning coordination chemistry through the second sphere in designed metallocoiled coils The metal hydration state within a designed coiled coil can be progressively tuned across the full integer range (3 → 0 aqua ligands), by careful choice of a second sphere terminal residue, including the lesser used Trp. Potential implications include a four-fold change in MRI relaxivity when applie... 3/5/2020
Ravi R Shah, Ivy W Maina, Neil N Patel, Vasiliki Triantafillou, Alan D Workman, Edward C Kuan, Charles C L Tong, Michael A Kohanski, Bert W O'Malley, Nithin D Adappa, James N Palmer Incidence, risk factors, and outcomes of endoscopic sinus surgery after endoscopic skull-base surgery CONCLUSION: A significant proportion of patients develop clinically significant sinusitis after endoscopic SBS for neoplasms with combined sinonasal and skull base involvement and may benefit from rESS. Intervention occurred, on average, 3.5 years after initial tumor resection. Malignant pathology, ... 2/28/2020
Michael L Rosenberg, Vahid Tohidi, Karna Sherwood, Sujoy Gayen, Rosina Medel, Gad M Gilad Evidence for Dietary Agmatine Sulfate Effectiveness in Neuropathies Associated with Painful Small Fiber Neuropathy A Pilot Open-Label Consecutive Case Series Study Peripheral neuropathies associated with painful small fiber neuropathy (SFN) are complex conditions, resistant to treatment with conventional medications. Previous clinical studies strongly support the use of dietary agmatine as a safe and effective treatment for neuropathic pain. Based on this evid... 2/28/2020
Anna Claudia Massolo, Flaminia Calzolari, Marco Cosimo Campanale, Neil Patel, Ferdinando Savignoni, Andrea Dotta, Annabella Braguglia, Pietro Bagolan, Alessandra Toscano Myocardial strain in newborn infants with tracheomalacia due to vascular rings, a pilot study CONCLUSIONS: In cases of VR with severe tracheomalacia RV and LV myocardial strain is reduced, suggesting secondary cardiac dysfunction. 2/26/2020
Vasiliki Triantafillou, Ivy W Maina, Neil N Patel, Charles C L Tong, Peter Papagiannopoulos, Michael A Kohanski, David W Kennedy, James N Palmer, Nithin D Adappa, Noam A Cohen, John V Bosso In vitro safety of ketotifen as a topical nasal rinse CONCLUSION: Topical application of ketotifen to an in vitro model of sinonasal epithelium is safe, as evaluated by CBF and lactate dehydrogenase. Ketotifen is neither ciliotoxic nor ciliostimulatory, and no long-term cellular toxicity was observed. Ketotifen may have promise as a topical nasal rinse... 2/23/2020
Michael K Slevin, Bruce M Wollison, Winslow Powers, Robert T Burns, Neil Patel, Matthew D Ducar, Gabriel J Starrett, Elizabeth P Garcia, Danielle K Manning, Jingwei Cheng, Glenn J Hanna, Kenneth M Kaye, Paul Van Hummelen, Anwesha Nag, Aaron R Thorner, James A DeCaprio, Laura E MacConaill ViroPanel Hybrid Capture and Massively Parallel Sequencing for Simultaneous Detection and Profiling of Oncogenic Virus Infection and Tumor Genome Precision cancer medicine aims to classify tumors by site, histology, and molecular testing to determine an individualized profile of cancer alterations. Viruses are a major contributor to oncogenesis, causing 12% to 20% of all human cancers. Several viruses are causal of specific types of cancer, p... 2/19/2020
Samuel R Marcrom, Paul M Foreman, Tyler B Colvin, Andrew M McDonald, Robert S Kirkland, Richard A Popple, Kristen O Riley, James M Markert, Christopher D Willey, Markus Bredel, John B Fiveash Focal Management of Large Brain Metastases and Risk of Leptomeningeal Disease CONCLUSIONS: Surgery is appropriate for certain brain metastases, but S + SRS may increase LMD risk compared with FSRT alone. Because S + SRS and FSRT seem to have similar LC, FSRT may be a viable alternative to S + SRS in select patients with large brain metastases. 2/14/2020
Jennifer A Smith, Amanda Sosulski, Ramy Eskander, Ashkan Moazzez, Neil Patel, Brant Putnam, Dennis Y Kim Implementation of a multidisciplinary perinatal emergency response team improves time to definitive obstetrical evaluation and fetal assessment BACKGROUND: Trauma is the leading cause of nonobstetric death during pregnancy and is associated with an increased risk of maternal and fetal mortality. In an effort to improve the delivery of care to pregnant trauma patients, we developed an institutional multidisciplinary quality initiative design... 2/12/2020
Omar Dawood, Seena Tabibi, Julia Fiuk, Neil Patel, Ahmed El-Zawahry Penile ring entrapment - A true urologic emergency Grading, approach, and management Penile rings are used to sustain erection in order to enhance sexual pleasure. They work by reducing the outflow of blood from the cavernosal tissue. However, if left for extended periods of time severe edema, urethral fistula, gangrene, and even complete loss of the distal penis can ensue, this is ... 2/5/2020
Neil S Patel, Alice E Huang, Eric M Dowling, Katherine A Lees, Nicole M Tombers, Christine M Lohse, John P Marinelli, Jamie J Van Gompel, Brian A Neff, Colin L W Driscoll, Michael J Link, Matthew L Carlson The Influence of Vestibular Schwannoma Tumor Volume and Growth on Hearing Loss CONCLUSION: Larger initial VS tumor volume was associated with poorer hearing at baseline. Larger initial tumor volume was also associated with the development of nonserviceable hearing during observation in a univariable setting; however, this association was not statistically significant after adj... 1/29/2020
Neil D Patel, Patrick M Sullivan, Arash Sabati, Allison Hill, Chelsea Maedler-Kron, Shengmei Zhou, Nick Shillingford, Roberta Williams, Cheryl Takao, Sarah Badran Routine Surveillance Catheterization is Useful in Guiding Management of Stable Fontan Patients We developed a Fontan surveillance catheterization protocol as part of routine assessment of stable patients 10 years after Fontan completion. The surveillance catherization includes hemodynamic assessment with inhaled nitric oxide, angiography, liver biopsy, and transcatheter intervention if indica... 1/26/2020
Rita Snyder, Terence Verla, Alexander E Ropper Practical Application of Recent Advances in Diagnostic, Prognostic, and Therapeutic Modalities for Spinal Cord Injury CONCLUSIONS: Recent advances in accurate, timely, and practical classification methods of acute spinal cord injury will assist in the development of novel treatment approaches for both acute and chronic injury alike. 1/14/2020
Neil S Patel, Aniket A Saoji, Amy P Olund, Matthew L Carlson Monitoring Cochlear Nerve Integrity During Vestibular Schwannoma Microsurgery in Real-Time Using Cochlear Implant Evoked Auditory Brainstem Response and Streaming Neural Response Imaging CONCLUSIONS: This report demonstrates the feasibility of using real-time NRI and eABR with a CI to facilitate preservation of the cochlear nerve during VS microsurgery. Using this method to mitigate cochlear nerve trauma during microsurgery may preserve the option of CI for hearing rehabilitation. 1/11/2020
Reid Hoshide, Robert C Rennert, Carlos E Sanchez, Joel R Martin, Vincent J Cheung, Gayle Gyles, Michael L Levy Rate-controlled intraventricular endoscopic irrigation via bipolar foot pedal activation technical note Irrigation during intraventricular endoscopic surgery is critical for visualization, with normal intracranial pressure maintained by balancing fluid ingress and egress. Although irrigation is typically achieved through manual manipulation of inexact stopcocks, the authors have developed a rate-contr... 12/28/2019
Tara N B Daming, Karen L Florio, Laura M Schmidt, Anna Grodzinsky, Lynne A Nelson, Kathleen C Swearingen, Darcy L White, Neil B Patel, Rebecca A Gray, Valerie J Rader, John K Lee, John A Spertus, Anthony Magalski Creating a maternal cardiac center of excellence a call to action In contrast to most industrialized countries, maternal mortality in the USA is rising. Cardiovascular disease, both acquired heart disease (e.g. coronary disease, arrhythmias, and heart failure), as well as congenital heart disease survivors, are all potentially important factors in explaining this ... 12/27/2019
Randeep S Heer, Neil B Patel, Amit K J Mandal, Fiona Lewis, Constantinos G Missouris Not a fungi to be with Shiitake mushroom flagellate dermatitis Shiitake dermatitis is a rare adverse cutaneous reaction to the ingestion of raw or undercooked shiitake mushrooms (Lentinula edodes). We report the case of a patient who developed a striking linear flagellate dermatitis without urticaria three days after returning from a trip from Tokyo where he ha... 12/23/2019
Mirja M Wirtz, Philipp Hendrix, Oded Goren, Lisa A Beckett, Heather R Dicristina, Clemens M Schirmer, Shamsher Dalal, Gregory Weiner, Paul M Foreman, Ramin Zand, Christoph J Griessenauer Predictor of 90-day functional outcome after mechanical thrombectomy for large vessel occlusion stroke NIHSS score of 10 or less at 24 hours CONCLUSIONS: An NIHSS score ≤ 10 at 24 hours after mechanical thrombectomy was independently associated with good functional outcome at 90 days. 12/21/2019
Mirja M Wirtz, Clemens M Schirmer, Oded Goren, Christian O Bohan, Shamsher Dalal, Gregory Weiner, Paul M Foreman, Christoph J Griessenauer Utility of platelet function testing in stent-assisted coiling of cerebral aneurysms CONCLUSION: In patients where the pharmacy-mediated antiplatelet protocol was followed, the thromboembolic complication rate was 1.8%. This complication rate compares favorably to those reported in large contemporary series. Nevertheless, the pharmacy-mediated protocol places a significant burden on... 12/21/2019
Naoir Zaher, Kevin Haas, Hasan Sonmezturk, Amir Arain, Bassel Abou-Khalil Rhythmic ictal nonclonic hand RINCH motions in general EMU patients with focal epilepsy CONCLUSION: The RINCH motions are a common sign in focal seizures and should be distinguished from other types of manual automatism as they carry a strong lateralizing value. 12/19/2019
Alice E Huang, Weston J Adkins, Neil S Patel Cochlear Implantation in Craniometaphyseal Dysplasia CONCLUSION: This report describes the first description of CI for CMD. Despite the extensive radiologic abnormalities, the patient has demonstrated excellent benefit from implantation. Further study of rare temporal bone dysplasias, such as CMD, is critical to better characterize the progression of ... 12/14/2019
Neil D Patel, Patrick M Sullivan, Cheryl M Takao, Sarah Badran, Frank F Ing Stent treatment of ostial branch pulmonary artery stenosis initial and medium-term outcomes and technical considerations to avoid and minimise stent malposition CONCLUSION: Ostial branch pulmonary artery stenosis may require additional angiography to accurately define the ostial stenosis. Treatment with stents is effective but carries high rates of stent malposition. 12/14/2019
Peter Papagiannopoulos, Kyle Devins, Charles Ching Lick Tong, Christina Yver, Neil N Patel, Hannah N Kuhar, John V Bosso, Michael A Kohanski, Bobby A Tajudeen, Edward C Kuan, Pete S Batra, Noam A Cohen, David W Kennedy, James N Palmer, Kathy Montone, Nithin D Adappa Chronic rhinosinusitis precipitated by tumor necrosis factor alpha inhibitors is the phenotype of chronic rhinosinusitis without nasal polyps CONCLUSION: CRSαi exhibits structured histopathology more similar to CRSsNP. In the appropriate clinical context, it may be reasonable that the medical regimen for these patients be focused on a more antineutrophilic, macrolide-based approach. This study provides insight into the inflammatory enviro... 12/4/2019
Michael G Hill, Erich Königsberger, Peter M May Predicting the risk of kidney stone formation in the nephron by reverse engineering Although most kidney stones are found in the calyx, they are usually initiated upstream in the nephron by precipitation there of certain incipient mineral phases. The risk of kidney stone formation can thus be indicated by changes in the degree of saturation of these minerals in the nephron fluid. T... 11/28/2019
Robert Y North, Terence Verla, Erica Bartlett, Edward Reece, Howard L Weiner, Alexander E Ropper Giant Symptomatic Meningocele as a Delayed, Adult Complication of Lipomyelomeningocele CONCLUSIONS: Symptomatic meningocele may present in a long-delayed fashion in adult patients with a history of spina bifida. Surgical treatment may provide symptomatic benefit. 11/25/2019
Paul M Foreman, Mohamed M Salem, Christoph J Griessenauer, Adam A Dmytriw, Carmen Parra-Farinas, Patrick Nicholson, Nicola Limbucci, Anna Luisa Kühn, Ajit S Puri, Leonardo Renieri, Sergio Nappini, Kimberly P Kicielinski, Alejandro Bugarini, Vitor Mendes Pereira, Thomas R Marotta, Clemens M Schirmer, Christopher S Ogilvy, Ajith J Thomas Flow Diversion for Treatment of Partially Thrombosed Aneurysms A Multicenter Cohort CONCLUSIONS: Flow diversion treatment of PTIA has adequate efficacy along with a reasonable safety profile. Aneurysms harboring large amounts of pretreatment thrombus were associated with lower rates of complete occlusion. 11/25/2019
Eric M Dowling, Neil S Patel, Christine M Lohse, Colin L W Driscoll, Brian A Neff, Jamie J Van Gompel, Michael J Link, Matthew L Carlson Durability of Hearing Preservation Following Microsurgical Resection of Vestibular Schwannoma CONCLUSION: Microsurgical resection provides excellent tumor control and durable long-term hearing in those with AAO-HNS class A or B hearing postoperatively. The paradigm of proactive microsurgical resection-when the tumor is small and hearing is good-hinges on the surgeon's ability to preserve res... 11/15/2019
Tammy B Pham, Shanmukha Srinivas, Joel R Martin, Michael G Brandel, Arvin R Wali, Robert C Rennert, Jeffrey A Steinberg, David R Santiago-Dieppa, Todd W Costantini, Alexander A Khalessi Risk Factors for Urinary Tract Infection or Pneumonia After Admission for Traumatic Subdural Hematoma at a Level I Trauma Center Large Single-Institution Series CONCLUSIONS: Patients with prolonged hospitalizations and/or intensive care unit stays were more likely to experience UTIs and pneumonia. Male gender and younger age were protective against UTI, and higher GCS was protective against pneumonia. These data may aid the identification and treatment of a... 11/13/2019
Neil Patel, Derya Arkonac, Shunsuke Aoi, Dennis Finkielstein Infective Endocarditis of a Left Ventricular Myxoma in a Heroin User Infected cardiac myxomas are rare and can have disastrous sequelae; urgent surgical resection is typically indicated. We report the case of a 43-year-old user of intravenous heroin who presented with weakness and dyspnea. He was diagnosed with infective endocarditis of a myxoma attached to the left ... 11/12/2019
Tomasz Sewastianik, Maria Luisa Guerrera, Keith Adler, Peter S Dennis, Kyle Wright, Vignesh Shanmugam, Ying Huang, Helen Tanton, Meng Jiang, Amanda Kofides, Maria G Demos, Audrey Dalgarno, Neil A Patel, Anwesha Nag, Geraldine S Pinkus, Guang Yang, Zachary R Hunter, Petr Jarolim, Nikhil C Munshi, Steven P Treon, Ruben D Carrasco Human MYD88L265P is insufficient by itself to drive neoplastic transformation in mature mouse B cells MYD88 L265P is the most common mutation in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) and one of the most frequent in poor-prognosis subtypes of diffuse large B-cell lymphoma (DLBCL). Although inhibition of the mutated MYD88 pathway has an adverse impact on LPL/WM and DLBCL ce... 11/8/2019
Suzan Cochius-den Otter, Thomas Schaible, Anne Greenough, Arno van Heijst, Neil Patel, Karel Allegaert, Joost van Rosmalen, Dick Tibboel, CDH EURO Consortium The CoDiNOS trial protocol an international randomised controlled trial of intravenous sildenafil versus inhaled nitric oxide for the treatment of pulmonary hypertension in neonates with congenital diaphragmatic hernia INTRODUCTION: Congenital diaphragmatic hernia (CDH) is a developmental defect of the diaphragm that impairs normal lung development, causing pulmonary hypertension (PH). PH in CDH newborns is the main determinant for morbidity and mortality. Different therapies are still mainly based on 'trial and e... 11/8/2019
Derek C Monroe, Neil R Patel, Kevin K McCully, Rodney K Dishman The effects of exercise on mood and prefrontal brain responses to emotional scenes in smokers The benefits of exercise for smokers attempting to quit are partially dependent on physical activity levels prior to cessation. Mood disturbances can manifest within 30 min of smoking a cigarette and contribute to negative reinforcement of smoking behavior over time, whereas a single bout of aerobic... 11/1/2019
Janell Holloway, Elle Lett, Lobsang Marcia, Brant Putnam, Angela Neville, Neil Patel, Vincent Chong, Dennis Y Kim Primary Skin Closure after Repair of Hollow Viscus Injuries Decisions regarding whether to close the skin in trauma patients with hollow viscus injuries (HVIs) are based on surgeon discretion and the perceived risk for an SSI. We hypothesized that leaving the skin open would result in fewer wound complications in patients with HVIs. We performed a retrospect... 10/29/2019
Aniket A Saoji, Neil S Patel, Matthew L Carlson, Brian A Neff, Kanthaiah Koka, Venkata S Aditya Tarigoppula, Colin L W Driscoll Multi-frequency Electrocochleography Measurements can be Used to Monitor and Optimize Electrode Placement During Cochlear Implant Surgery CONCLUSION: We present a report on simultaneous multi-frequency ECOG monitoring during cochlear implant surgery. Multi-frequency ECOG can be used to differentiate between electrode trauma and the advancement of the apical electrode beyond the CM source in the cochlea. 10/24/2019
Hiten D Patel, Farzana A Faisal, Neil D Patel, Christian P Pavlovich, Mohamad E Allaf, Misop Han, Amin S Herati Effect of a prospective opioid reduction intervention on opioid prescribing and use after radical prostatectomy results of the Opioid Reduction Intervention for Open, Laparoscopic, and Endoscopic Surgery ORIOLES Initiative CONCLUSIONS: A prospective, evidence-based intervention reduced post-discharge opioid prescribing and use, while increasing disposal after RP. Risk factors for increased opioid use were identified. The results support expanding the use of evidence-based opioid reduction interventions to other surgic... 10/24/2019
Aoife Ryan, Megan Gilhooley, Neil Patel, Ben C Reynolds Prevalence of Acute Kidney Injury in Neonates with Congenital Diaphragmatic Hernia CONCLUSIONS: AKI is common in CDH cases treated in our centre and is associated with adverse outcomes. Potentially modifiable risk factors include nephrotoxic medication exposure. Prevention and early recognition of contributory factors for AKI may improve outcomes in CDH. 10/23/2019
Ivy W Maina, Charles C L Tong, Esther Baranov, Neil N Patel, Vasiliki Triantafillou, Edward C Kuan, Michael A Kohanski, Peter Papagiannopoulos, Carol H Yan, Alan D Workman, Justina L Lambert, Noam A Cohen, David W Kennedy, Nithin D Adappa, Michael D Feldman, James N Palmer Clinical Implications of Carcinoma In Situ in Sinonasal Inverted Papilloma CONCLUSIONS: IPwCIS represents the most severe degree of dysplasia prior to malignant transformation and is associated with higher recurrence rate and multifocal involvement but low rate of conversion to invasive carcinoma. The need for adjuvant therapy remains controversial, and further research in... 10/23/2019
Sasha Vaziri, Dennis Timothy Lockney, Alexander B Dru, Adam J Polifka, W Christopher Fox, Daniel J Hoh Does Ossification of the Posterior Longitudinal Ligament Progress After Fusion Starting in the 1960s, ossification of the posterior longitudinal ligament (OPLL) became more commonly diagnosed in Japan. The disease is characterized by a gradual increase in calcification of the posterior longitudinal ligament with the eventual sequelae of cervical canal stenosis and myelopathy. ... 10/15/2019
Alexander B Dru, Dennis Timothy Lockney, Sasha Vaziri, Matthew Decker, Adam J Polifka, W Christopher Fox, Daniel J Hoh Cervical Spine Deformity Correction Techniques Cervical kyphotic deformity can be a debilitating condition with symptoms ranging from mechanical neck pain, radiculopathy, and myelopathy to impaired swallowing and horizontal gaze. Surgical correction of cervical kyphosis has the potential to halt progression of neurological and clinical deteriora... 10/15/2019
Neil Patel, David Scott-Coombes Impact of surgical volume and surgical outcome assessing registers on the quality of thyroid surgery The available evidence concerning the relationship between volume and outcome for thyroid surgery is assessed in this article. Morbidity forms the principal surrogate marker of thyroid surgery quality for which postoperative hypocalcaemia and recurrent laryngeal nerve injuries are most commonly repo... 9/19/2019
Laura Montier, Zulfi Haneef, Jay Gavvala, Daniel Yoshor, Robert North, Terence Verla, Paul C Van Ness, Janice Drabek, Alica M Goldman A somatic mutation in MEN1 gene detected in periventricular nodular heterotopia tissue obtained from depth electrodes Periventricular nodular heterotopia (PNH) is a common structural malformation of cortical development. Mutations in the filamin A gene are frequent in familial cases with X-linked PNH. However, many cases with sporadic PNH remain genetically unexplained. Although medically refractory epilepsy often ... 9/7/2019
Neil S Patel, Michael J Link, Colin L W Driscoll, Brian A Neff, Jamie J Van Gompel, John I Lane, Matthew L Carlson Involvement of the Cochlear Aqueduct by Jugular Paraganglioma Is Associated With Sensorineural Hearing Loss CONCLUSIONS: Cochlear aqueduct involvement by JP is associated with SNHL in the absence of inner ear fistula, vestibulocochlear nerve involvement, or brainstem compression. Correlation with operative findings or histopathologic evidence of tumor involvement may validate this intriguing imaging findi... 8/31/2019
Robert J Macielak, Neil S Patel, Katherine A Lees, Christine M Lohse, John P Marinelli, Michael J Link, Matthew L Carlson Delayed Tumor Growth in Vestibular Schwannoma An Argument for Lifelong Surveillance CONCLUSIONS: Delayed growth encompassed 8.1% of growing VSs and 3.9% of all observed tumors. Patients with delayed growth exhibited slower growth rates compared with those who were diagnosed with growth early in their observation course. These findings support the need for lifelong surveillance of u... 8/31/2019
Neil Patel, Anna Claudia Massolo, Florian Kipfmueller Congenital diaphragmatic hernia-associated cardiac dysfunction There is increasing evidence that cardiac dysfunction is a key contributor to CDH pathophysiology. Dysfunction in both right and left ventricles is common in the early neonatal period, contributes to clinical disease severity, and is associated with adverse outcomes including death and ECMO use. Ear... 8/18/2019
Anna Claudia Massolo, Stefania Sgrò, Fiammetta Piersigilli, Karel Allegaert, Irma Capolupo, Jole Rechichi, Francesca Landolfo, Flaminia Calzolari, Alessandra Toscano, Sergio Picardo, Neil Patel Propofol Formulation Affects Myocardial Function in Newborn Infants This study aimed to evaluate the effects of propofol in diluted and undiluted formulations on cardiac function in infants. Infants > 30 days received propofol sedation for central line insertion. Cases were divided into two groups: those who received undiluted 1% propofol (P1%); and those who receiv... 8/16/2019
Neil Patel, Pamela A Lally, Florian Kipfmueller, Anna Claudia Massolo, Matias Luco, Krisa P Van Meurs, Kevin P Lally, Matthew T Harting Ventricular Dysfunction Is a Critical Determinant of Mortality in Congenital Diaphragmatic Hernia Rationale: Congenital diaphragmatic hernia (CDH) is an anomaly with a high morbidity and mortality. Cardiac dysfunction may be an important and underrecognized contributor to CDH pathophysiology and determinant of disease severity.Objectives: Our aim was to investigate the association between early,... 8/15/2019
Mehran Ganji, Angelique C Paulk, Jimmy C Yang, Nasim W Vahidi, Sang Heon Lee, Ren Liu, Lorraine Hossain, Ezequiel M Arneodo, Martin Thunemann, Michiko Shigyo, Atsunori Tanaka, Sang Baek Ryu, Seung Woo Lee, Youngbin Tchoe, Martin Marsala, Anna Devor, Daniel R Cleary, Joel R Martin, Hongseok Oh, Vikash Gilja, Timothy Q Gentner, Shelley I Fried, Eric Halgren, Sydney S Cash, Shadi A Dayeh Selective Formation of Porous Pt Nanorods for Highly Electrochemically Efficient Neural Electrode Interfaces The enhanced electrochemical activity of nanostructured materials is readily exploited in energy devices, but their utility in scalable and human-compatible implantable neural interfaces can significantly advance the performance of clinical and research electrodes. We utilize low-temperature selecti... 8/2/2019
Neil Patel, Arfon G Powell, Jenni R Wheat, Christopher Brown, Ian R Appadurai, Richard G Davies, Damian M Bailey, Wyn G Lewis Cardiopulmonary fitness predicts postoperative major morbidity after esophagectomy for patients with cancer Surgery for radical treatment of esophageal cancer (EC) carries significant inherent risk. The objective identification of patients who are at high risk of complications is of importance. In this study the prognostic value of cardiopulmonary fitness variables (CPF) derived from cardiopulmonary exerc... 7/26/2019
Philipp Hendrix, Paul M Foreman, Sebastian Senger, Benedikt W Burkhardt, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Beverly C Walters, R Shane Tubbs, Mohammadali M Shoja, Christoph J Griessenauer Loss of consciousness at onset of aneurysmal subarachnoid hemorrhage in good-grade patients Loss of consciousness (LOC) at presentation with aneurysmal subarachnoid hemorrhage (aSAH) has been associated with early brain injury and poor functional outcome. The impact of LOC on the clinical course after aSAH deserves further exploration. A retrospective analysis of 149 aSAH patients who were... 7/24/2019
Neil S Patel, Jamie J Van Gompel, Nicole M Tombers, Michael J Link, Matthew L Carlson A Cross-Sectional Survey of the North American Skull Base Society Part 3 The State of Lateral Skull Base Surgery Training in North America Introduction Optimal management of vestibular schwannoma (VS) demands involvement of an experienced multidisciplinary team. As the number of training programs in neurotology and skull base neurosurgery continues to rise, ensuring that trainees are capable of evidence-based decision-making and treatm... 7/19/2019
Vasiliki Triantafillou, Ivy W Maina, Edward C Kuan, Michael A Kohanski, Charles C Tong, Neil N Patel, Ryan M Carey, Alan D Workman, James N Palmer, Nithin D Adappa, Jason A Brant Sinonasal mucoepidermoid carcinoma a review of the National Cancer Database CONCLUSION: Mucoepidermoid carcinoma is the most common salivary gland malignancy but a rare sinonasal malignancy, with 5-year survival for SN-MEC approximating 50%. A significant proportion of patients present with advanced disease. Both socioeconomic factors and tumor characteristics are associate... 7/18/2019
Jeremie D Oliver, Neil S Patel, Dale C Ekbom, Janalee K Stokken Novel synchronous nasal involvement of inverted papilloma and recurrent respiratory papillomatosis with confirmed human papillomavirus isolated from nasal septum and middle turbinate a case report CONCLUSIONS: This report emphasizes the importance of considering a broad differential diagnosis in patients with papillomata, and obtaining comprehensive histopathologic evaluation of lesions in multiple subsites in order to rule out inverted papilloma or overt malignant transformation, particularl... 7/16/2019
Vasileios Kokkinos, Naoir Zaher, Arun Antony, Anto Bagić, R Mark Richardson, Alexandra Urban The intracranial correlate of the 14amp;6sec positive spikes normal scalp EEG variant CONCLUSIONS: The 14&6/sec positive spikes variant correlates with bursts of negative polarity spikes in the ipsilateral hippocampus. 7/15/2019
Omar Awan, Kyle W Scott, Sasha Vaziri, Ken Porche, Matthew Decker, Alexander B Dru, Saptarshi Chakraborty, Kshitij Khare, Brian Hoh, Maryam Rahman Reimbursement patterns for neurosurgery Analysis of the NERVES survey results from 2011-2016 CONCLUSION: These data demonstrate neurosurgical reimbursement and productivity have trended down during a time that increases in productivity and reimbursement were predicted. This phenomenon is most notable in academic practices compared to private or hospital based practices. Prospective analyses... 7/15/2019
Mingkuan Lin, Christoph J Griessenauer, Robert M Starke, R Shane Tubbs, Mohammadali M Shoja, Paul M Foreman, Nilesh A Vyas, Beverly C Walters, Mark R Harrigan, Philipp Hendrix, Winfield S Fisher, Jean-Francois Pittet, Mali Mathru, Robert H Lipsky Haplotype analysis of SERPINE1 gene Risk for aneurysmal subarachnoid hemorrhage and clinical outcomes CONCLUSION: The results suggested an important regulatory role of the SERPINE1 gene polymorphism in clinical outcomes of aSAH. 7/4/2019
Miguel Mayol, Fanor M Saavedra, Rodolfo Alcedo, Gisela Murray, Emil A Pastrana Time of Surgery in the Outcome of Cervical Spinal Cord Injury the University of Puerto Rico Experience CONCLUSION: Traumatic cervical spinal cord injury is associated with high mortality and morbidity. Early surgery was not associated with an improved neurological outcome at long-term follow-up. The benefit of early surgery was seen only in terms of decreasing each patient's length of hospital stay. 7/2/2019
Samuel P Trethewey, Neil Patel, Alice M Turner Interventions to Increase the Rate of Influenza and Pneumococcal Vaccination in Patients with Chronic Obstructive Pulmonary Disease A Scoping Review Background and Objective: Current evidence suggests that patients with chronic obstructive pulmonary disease (COPD) should receive influenza and pneumococcal vaccinations. Despite international guidelines recommending vaccination in patients with COPD, many patients remain unvaccinated. Reasons for ... 6/19/2019
Bradley C Holland, Neil Patel, Randy Sulaver, Bradford Stevenson, Jessica Healey, William Severino, Thomas Baron, David Lieber, David Roszhart, Kevin T McVary, Tobias S Köhler Resident Impact on Patient amp; Surgeon Satisfaction and Outcomes Evidence for Health System Support for Urology Education CONCLUSION: Resident coverage of a private practice urology group resulted in no difference in surgical complications and improvement in readmission rates in nonsurgical patients. It resulted in longer OR times but greater satisfaction of faculty, residents and most important, patients. Our data dem... 6/14/2019
Vikram Shivkumar, Dipali Nemade Intravenous tPA in the treatment of acute stroke related to aortic dissection A 61-year-old woman with no prior medical illness presented with acute onset stroke symptoms. She had no chest pain at the time of presentation. However, CT angiogram showed an extensive aortic dissection, resulting in hypoperfusion of the right cerebral hemisphere and thus causing stroke symptoms. ... 6/6/2019
Branca I Pereira, Oliver P Devine, Milica Vukmanovic-Stejic, Emma S Chambers, Priya Subramanian, Neil Patel, Alex Virasami, Neil J Sebire, Veronica Kinsler, Alexis Valdovinos, Claude Jourdan LeSaux, João F Passos, Antony Antoniou, Malcom H A Rustin, Judith Campisi, Arne N Akbar Senescent cells evade immune clearance via HLA-E-mediated NK and CD8supsup T cell inhibition Senescent cells accumulate in human tissues during ageing and contribute to age-related pathologies. The mechanisms responsible for their accumulation are unclear. Here we show that senescent dermal fibroblasts express the non-classical MHC molecule HLA-E, which interacts with the inhibitory recepto... 6/5/2019
Yening Feng, Neil S Patel, Jamie J Van Gompel, Matthew L Carlson Translabyrinthine Approach for Resection of Vestibular Schwannoma Objectives This video describes the surgical indications, relevant anatomy, and surgical steps of routine translabyrinthine surgery for gross total resection of sporadic vestibular schwannoma. Design The procedure is presented through a surgical instructional video. Setting The surgery took place at... 5/31/2019
Neil S Patel, Michael J Link, Nicole M Tombers, Bruce E Pollock, Matthew L Carlson Quality of Life in Jugular Paraganglioma Following Radiosurgery CONCLUSIONS: Patients treated with primary or staged SRS for JP tend to exhibit better swallowing outcomes than those treated with SRS for recurrent JP. However, the majority of overall and disease-specific quality of life measures were not different between groups. Based on the low incidence of new... 5/29/2019
Charles C L Tong, Neil N Patel, Ivy W Maina, Vasiliki Triantafillou, Carol H Yan, Edward C Kuan, Michael A Kohanski, Peter Papagiannopoulos, Alan D Workman, Noam A Cohen, David W Kennedy, Nithin D Adappa, James N Palmer Inverted papilloma with multifocal attachment is associated with increased recurrence CONCLUSION: Primary resection and single-focus attachment of inverted papilloma are associated with lower recurrence rates at 3-year follow-up. 5/25/2019
Stephan A Munich, Chandan Krishna, Marshall C Cress, Gurmeet S Dhillon, John Pollina, Elad I Levy Diagnosis and Endovascular Embolization of a Sacral Spinal Arteriovenous Fistula with Holo-Spinal Venous Drainage CONCLUSIONS: Selective transarterial catheterization and embolization with n-butyl cyanoacrylate resulted in complete occlusion of the AVF. Clinical improvement was also noted on postprocedural day 1. This case highlights the importance of internal iliac injections as a critical component of spinal ... 5/24/2019
Robert C Rennert, Joel R Martin, Michael G Brandel, Jeffrey A Steinberg, David R Santiago-Dieppa, Arvin R Wali, Todd W Costantini, Alexander A Khalessi Risk Factors for Venous Thromboembolism After Admission for Traumatic Subdural Hematoma at Level I Trauma Center Large Single-Institution Series CONCLUSIONS: While overall VTE risk is low following tSDH, elderly patients and those with severe injuries requiring prolonged hospitalizations have increased thrombotic risk. Development of tiered VTE prophylaxis regimens based on early postinjury thrombotic risk profiles warrants future study. 5/21/2019
Anna Claudia Massolo, Anshuman Paria, Lindsey Hunter, Emma Finlay, Carl F Davis, Neil Patel Ventricular Dysfunction, Interdependence, and Mechanical Dispersion in Newborn Infants with Congenital Diaphragmatic Hernia CONCLUSIONS: Global impairment of RV and LV systolic function are present in newborn infants with CDH and are associated with primary left ventricular dysfunction, ventricular interdependence, and MD. 5/16/2019
Georgios A Maragkos, Luis C Ascanio, Mohamed M Salem, Sricharan Gopakumar, Santiago Gomez-Paz, Alejandro Enriquez-Marulanda, Abhi Jain, Clemens M Schirmer, Paul M Foreman, Christoph J Griessenauer, Peter Kan, Christopher S Ogilvy, Ajith J Thomas Predictive factors of incomplete aneurysm occlusion after endovascular treatment with the Pipeline embolization device CONCLUSIONS: Incomplete aneurysm occlusion following placement of a PED was independently associated with age > 70 years, aneurysm diameter ≥ 15 mm, and fusiform morphology. Such predictive factors can be used to guide individualized treatment selection and counseling in patients undergoing cerebrov... 4/27/2019
Robert C Rennert, Reid Hoshide, Michael G Brandel, Jeffrey A Steinberg, Joel R Martin, Hal S Meltzer, David D Gonda, Takanori Fukushima, Alexander A Khalessi, Michael L Levy Surgical relevance of pediatric skull base maturation for the far-lateral and extreme-lateral infrajugular transcondylar-transtubercular exposure approaches CONCLUSIONS: When considering a far-lateral or ELITE approach in pediatric patients, standard OC drilling is likely to be needed due to the relative stability of OC and HGC anatomy during development. The JT significantly increases in size with development, yet is only likely to need to be drilled i... 4/27/2019
Alexander B Dru, Brett Reichwage, Dan Neal, Sasha Vaziri, Dennis Timothy Lockney, W Christopher Fox, Brian L Hoh, Daniel J Hoh Race and socioeconomic disparity in treatment and outcome of traumatic cervical spinal cord injury with fracture Nationwide Inpatient Sample database, 1998-2009 CONCLUSIONS: Despite trending improved outcomes after TCSCIF, LSES, or AA race were more likely to have worse outcomes compared to their counterparts. In addition, LSES, AA, and Hispanic groups were less likely to undergo surgical treatment, suggesting disparities in management and outcome effect. 4/18/2019
Neil D Patel, Henri Justino, Frank F Ing Hybrid approach to ventricular septal defect enlargement The need for creation or enlargement of a ventricular septal defect (VSD) is a rare occurrence. It is most frequently required in patients with double-outlet right ventricle who develop restriction of a remote muscular VSD or obstruction of a perimembranous VSD secondary to atrioventricular (AV) val... 4/16/2019
Yening Feng, Neil S Patel, Anthony M Burrows, John I Lane, Aditya Raghunathan, Jamie J Van Gompel, Matthew L Carlson Expansile Traumatic Neuroma of the Intratemporal Facial Nerve Objectives To present a rare case of traumatic facial neuroma involving the geniculate ganglion and review relevant literature. Patient Thirty-year-old man. Intervention Microsurgical resection via combined mastoid-middle fossa approach with great auricular nerve interpositional graft. Main Outcome ... 4/4/2019
Chetan K Rane, Sergio R Jackson, Christopher F Pastore, Gan Zhao, Aaron I Weiner, Neil N Patel, De'Broski R Herbert, Noam A Cohen, Andrew E Vaughan Development of solitary chemosensory cells in the distal lung after severe influenza injury H1N1 influenza virus infection induces dramatic and permanent alveolar remodeling mediated by p63^(+) progenitor cell expansion in both mice and some patients with acute respiratory distress syndrome. This persistent lung epithelial dysplasia is accompanied by chronic inflammation, but the driver(s)... 3/26/2019
Neil N Patel, Vasiliki Triantafillou, Ivy W Maina, Alan D Workman, Charles C L Tong, Edward C Kuan, Peter Papagiannopoulos, John V Bosso, Nithin D Adappa, James N Palmer, Michael A Kohanski, De'Broski R Herbert, Noam A Cohen Fungal extracts stimulate solitary chemosensory cell expansion in noninvasive fungal rhinosinusitis CONCLUSION: Although fungal antigens are known to potentiate immune response through innate cytokines, including IL-25, the early expansion of SCCs in the presence of fungus has not been described. This early event in the pathogenesis of noninvasive fungal rhinosinusitis may represent a target for i... 3/21/2019
Zahra Tayarani-Najaran, Maryam Akaberi, Bahareh Hassanzadeh, Nazila Shirazi, Javad Asili, Hadi Al-Najjar, Amirhossein Sahebkar, Seyed Ahmad Emami Analysis of the Essential Oils of Five Artemisia Species and Evaluation of their Cytotoxic and Proapoptotic Effects BACKGROUND: In this study, the essential oil composition and cytotoxic activities of five Artemisia species were determined. 3/14/2019
Adam A Dmytriw, Kevin Phan, Mohamed M Salem, Nimer Adeeb, Justin M Moore, Christoph J Griessenauer, Paul M Foreman, Hussain Shallwani, Hakeem Shakir, Adnan H Siddiqui, Elad I Levy, Jason M Davies, Mark R Harrigan, Ajith J Thomas, Christopher S Ogilvy The Pipeline Embolization Device Changes in Practice and Reduction of Complications in the Treatment of Anterior Circulation Aneurysms in a Multicenter Cohort CONCLUSION: We report a notable drop in the rate of hemorrhagic and to a lesser extent thromboembolic complications with increased experience with PED in a multicenter cohort. Multiple factors are believed to contribute to this drop, including the evolved interpretation of platelet function testing,... 3/13/2019
Ivy W Maina, Neil N Patel, Noam A Cohen Understanding the Role of Biofilms and Superantigens in Chronic Rhinosinusitis PURPOSE OF REVIEW: This review explores recent discoveries in our understanding of how biofilms and superantigens contribute to the pathogenesis of chronic rhinosinusitis (CRS). It also examines clinical implications and novel treatment approaches for biofilm associated CRS. 3/13/2019
Edward C Kuan, Shruthi K Rereddy, Neil N Patel, Ivy W Maina, Vasiliki Triantafillou, Michael A Kohanski, Charles C L Tong, Seyed A Nabavizadeh, John Y K Lee, M Sean Grady, Bert W O'Malley, James N Palmer, Nithin D Adappa Asymptomatic radiographic sinonasal inflammation does not affect pituitary surgery outcomes CONCLUSION: In asymptomatic patients, radiographic evidence of sinonasal inflammation is not associated with increased risk of complications following TSA. 3/6/2019
Joseph P Antonios, Ghassan J Farah, Daniel R Cleary, Joel R Martin, Joseph D Ciacci, Martin H Pham Immunosuppressive mechanisms for stem cell transplant survival in spinal cord injury Spinal cord injury (SCI) has been associated with a dismal prognosis-recovery is not expected, and the most standard interventions have been temporizing measures that do little to mitigate the extent of damage. While advances in surgical and medical techniques have certainly improved this outlook, l... 3/6/2019
Roshan S Prabhu, Brandon E Turner, Anthony L Asher, Samuel R Marcrom, John B Fiveash, Paul M Foreman, Robert H Press, Kirtesh R Patel, Walter J Curran, William G Breen, Paul D Brown, Krishan R Jethwa, Inga S Grills, Jessica D Arden, Lauren M Foster, Matthew A Manning, Joseph D Stern, Scott G Soltys, Stuart H Burri A multi-institutional analysis of presentation and outcomes for leptomeningeal disease recurrence after surgical resection and radiosurgery for brain metastases CONCLUSIONS: Nodular LMD is a distinct pattern of LMD associated with postoperative SRS that is less likely to be symptomatic and has better OS outcomes than classical "sugarcoating" LMD. Although focal RT demonstrated increased second LMD recurrence compared with WBRT, there was no associated OS de... 3/5/2019
Adeel Ilyas, Diana Pizarro, Andrew K Romeo, Kristen O Riley, Sandipan Pati The centromedian nucleus Anatomy, physiology, and clinical implications Of all the truncothalamic nuclei, the centromedian-parafascicular nuclei complex (CM-Pf) is the largest and is considered the prototypic thalamic projection system. Located among the caudal intralaminar thalamic nuclei, the CM-Pf been described by Jones as "the forgotten components of the great loop... 3/5/2019
Lauren J Delaney, Daniel MacDonald, Jay Leung, Keith Fitzgerald, Alex M Sevit, John R Eisenbrey, Neil Patel, Flemming Forsberg, Christopher K Kepler, Taolin Fang, Steven M Kurtz, Noreen J Hickok Ultrasound-triggered antibiotic release from PEEK clips to prevent spinal fusion infection Initial evaluations Despite aggressive peri-operative antibiotic treatments, up to 10% of patients undergoing instrumented spinal surgery develop an infection. Like most implant-associated infections, spinal infections persist through colonization and biofilm formation on spinal instrumentation, which can include metal... 3/4/2019
Sasha Vaziri, Joseph M Abbatematteo, Max S Fleisher, Alexander B Dru, Dennis T Lockney, Paul S Kubilis, Daniel J Hoh Correlation of perioperative risk scores with hospital costs in neurosurgical patients CONCLUSIONS: Previous work has demonstrated that the ACS NSQIP surgical risk calculator can accurately predict mortality after neurosurgery but is poorly predictive of other potential adverse events and clinical outcomes. However, this study demonstrates that predicted high-risk patients identified ... 2/17/2019
Chandala Chitguppi, Ryan A Rimmer, Hermes G Garcia, Ian J Koszewski, Judd H Fastenberg, Gurston G Nyquist, Marc R Rosen, Colin Huntley, Mindy R Rabinowitz, James J Evans Evaluation of cranial base repair techniques utilizing a novel cadaveric CPAP model CONCLUSION: Different skull base repair techniques have varying ability to withstand CPAP. Both second and third repair techniques performed in a nearly similar fashion with regard to their ability to withstand positive pressure ventilation. 2/13/2019
Paul M Foreman, James Mooney, Adeel Ilyas, Bonita Agee, Sheela Vivekanandan, Reginald P Fong, Mamerhi O Okor, Kristen O Riley, Christoph J Griessenauer Antiplatelet Medication and Operative Subdural Hematomas A Retrospective Cohort Study Evaluating Reoperation Rates CONCLUSIONS: Antiplatelet medication was not a significant predictor of reoperation following evacuation of an acute or mixed-density SDH. In patients on antiplatelet medication, preoperative platelet transfusion did not reduce reoperation rates. 2/9/2019
Michal Trope, Vasiliki Triantafillou, Michael A Kohanski, Edward C Kuan, Charles C L Tong, Neil N Patel, Ivy W Maina, Ryan M Carey, Alan D Workman, James N Palmer, Nithin D Adappa, Jason G Newman, Jason A Brant Adenoid cystic carcinoma of the sinonasal tract a review of the national cancer database CONCLUSION: Predictors of survival in SNACC include age, comorbidity status, grade, and stage. Surgery is associated with improved survival and remains the mainstay of therapy, whereas the roles of radiation therapy and chemotherapy require future investigation. 1/16/2019
Mon-Lai Cheung, Shadi Rezai, Janelle M Jackman, Neil D Patel, Basem Z Bernaba, Omid Hakimian, Dilfuza Nuritdinova, Catherine L Turley, Ray Mercado, Takeko Takeshige, Sudha M Reddy, Paul N Fuller, Cassandra E Henderson Retained Intrauterine Device IUD Triple Case Report and Review of the Literature CONCLUSION: Patients in whom uterine perforation and IUD migration are suspected should have appropriate evaluation that includes transvaginal or transabdominal ultrasound or radiographs to confirm the position of the IUD, regardless of whether they are asymptomatic or present with symptoms. It is p... 1/11/2019
Vasiliki Triantafillou, Alan D Workman, Neil N Patel, Ivy W Maina, Charles C L Tong, Edward C Kuan, David W Kennedy, James N Palmer, Nithin D Adappa, Salomon Waizel-Haiat, Noam A Cohen Broncho-Vaxom OM-85 BV soluble components stimulate sinonasal innate immunity CONCLUSION: OM-85 BV has ciliostimulatory and immunogenic properties that may be partially responsible for its observed efficacy as a respiratory therapeutic. These responses were NO-dependent and consistent with T2R activation. Further work is necessary to elucidate specific component-receptor sign... 1/8/2019
Ryan A Rimmer, Alexander N Duffy, Alexander M Knops, Mindy R Rabinowitz, Ian J Koszewski, Marc R Rosen, Timothy Ortlip, Ryan N Heffelfinger, Hermes G Garcia, James J Evans, Gurston G Nyquist, Joseph M Curry The Role of Free Tissue Transfer in the Management of Chronic Frontal Sinus Osteomyelitis CONCLUSIONS: Extensive debridement followed by free tissue transfer and antibiotics offers a definitive treatment for complicated, recurrent frontal osteomyelitis. Simultaneous cranioplasty provides immediate protective and aesthetic benefit without complication. Consideration should be given for fr... 12/15/2018
Juan C Vicenty, Fanor M Saavedra, Juan A Vigo, Emil A Pastrana Circumferential Stabilization of the Thoracolumbar Junction Via Posterior-Only Approach for the Management of Burst Fractures CONCLUSION: The transpedicular approach for circumferential reconstruction and stabilization provides an alternative technique for the management of thoracolumbar fractures, having an acceptable risk and the associated lower morbidity of a posterioronly approach. 12/15/2018
Paul M Foreman, Alejandro Enriquez-Marulanda, James H Mooney, Philip G R Schmalz, Christoph J Griessenauer, John P Deveikis, Mark R Harrigan Whole blood aggregometry prior to Pipeline embolization device treatment of intracranial aneurysms defining an optimal platelet inhibition cutoff value for clopidogrel OBJECTIVEDual antiplatelet therapy is required for the treatment of intracranial aneurysms with the Pipeline embolization device (PED). Platelet function testing (PFT) is often used to assess the efficacy of the antiplatelet regimen prior to PED placement. The optimal impedance values for whole bloo... 12/1/2018
Ryan A Rimmer, Chandala Chitguppi, Hermes G Garcia, Ian J Koszewski, Gurston G Nyquist, Marc R Rosen, Colin Huntley, James J Evans, Mindy R Rabinowitz A cadaveric model for measuring sinonasal continuous positive airway pressure-a proof-of-concept study CONCLUSION: Our proof-of-concept cadaver model represents a novel approach to measure pressures delivered to the nasal cavity and anterior skull base by CPAP. With further study, it may have broader clinical application to guide the safe postoperative use of CPAP in this population. 11/16/2018
Neil N Patel, Alan D Workman, Noam A Cohen Role of Taste Receptors as Sentinels of Innate Immunity in the Upper Airway Evidence is emerging that shows taste receptors serve functions outside of taste sensation of the tongue. Taste receptors have been found in tissue across the human body, including the gastrointestinal tract, bladder, brain, and airway. These extraoral taste receptors appear to be important in modul... 10/27/2018
Hiten D Patel, Arnav Srivastava, Neil D Patel, Farzana A Faisal, Wesley Ludwig, Gregory A Joice, Zeyad R Schwen, Mohamad E Allaf, Misop Han, Amin S Herati A Prospective Cohort Study of Postdischarge Opioid Practices After Radical Prostatectomy The ORIOLES Initiative Opioid pain medications are overprescribed, but few data are available to help in appropriate tailoring of postdischarge opioid prescriptions after surgery. Prior studies are retrospective and based on incomplete responses (<50%) to questionnaires, with small sample sizes for any particular surgery.... 10/25/2018
Adeel Ilyas, Colin Przybylowski, Ching-Jen Chen, Dale Ding, Paul M Foreman, Thomas J Buell, Davis G Taylor, M Yashar Kalani, Min S Park Preoperative embolization of skull base meningiomas A systematic review Neoadjuvant endovascular embolization of skull base meningiomas may facilitate surgical resection, thereby potentially decreasing operative morbidity. However, due to variation in the reported efficacy and complication rates, the utility of embolization remains incompletely defined. The aim of this ... 10/4/2018
Neil D Patel, Richard W Kim, Suwanna Pornrattanarungsi, Pierre C Wong Morphology of intramural ventricular septal defects Clinical imaging and autopsy correlation An intramural ventricular septal defect (IVSD) is a type of interventricular communication that can occur following biventricular repair of a conotruncal malformation. There have been no previous reports depicting the actual pathologic anatomy of this defect. We describe two cases of IVSDs with thei... 10/2/2018
Neil N Patel, Michael A Kohanski, Ivy W Maina, Alan D Workman, De'Broski R Herbert, Noam A Cohen Sentinels at the wall epithelial-derived cytokines serve as triggers of upper airway type 2 inflammation Recent evidence has demonstrated an expanding role of respiratory epithelial cells in immune surveillance and modulation. Studies have been focusing on the earliest events that link epithelial injury to downstream inflammatory responses. Cytokines produced by and released from respiratory epithelial... 9/28/2018
Neil P Patel, Milica Vukmanovic-Stejic, Mayte Suarez-Farinas, Emma S Chambers, Daisy Sandhu, Judilyn Fuentes-Duculan, Neil A Mabbott, Malcolm H A Rustin, James Krueger, Arne N Akbar Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen-Specific Challenge CONCLUSION: Zostavax vaccination does not alter the abundance of cutaneous resident memory T cells but instead increases the recruitment of VZV-specific T cells from the blood and enhances T-cell activation, particularly cells of the CD8+ subset, in the skin after VZV antigen challenge. 9/25/2018
Neil S Patel, Matthew L Carlson Fluoroscopy-Assisted Transnasal Onyx Occlusion of the Eustachian Tube for Lateral Skull Base Cerebrospinal Fluid Leak Repair Objectives To describe transnasal Eustachian tube (ET) occlusion with a liquid embolic solution for lateral skull base cerebrospinal fluid (CSF) leaks. Design A lateral skull base CSF fistula model was developed by the authors using fresh cadaveric heads. Using a transtympanic needle, regulated pres... 9/14/2018
Alex D Sweeney, Brendan P O'Connell, Neil S Patel, Nicole M Tombers, George B Wanna, John I Lane, Matthew L Carlson Superior Canal Dehiscence Involving the Superior Petrosal Sinus A Novel Classification Scheme CONCLUSIONS: SSCD involving the SPS represents a small but distinct subset of SSCD cases. This scenario can create a unique set of symptoms and surgical challenges when intervention is sought. Clinical findings and considerations for surgical intervention are provided to facilitate effective diagnos... 9/11/2018
Susan B Fowler, Christian A Rosado, Jennifer Jones, Suzanne Ashworth, Darlene Adams Novel Use of a Nurse-Led Telemedicine Team in Acute Stroke A Retrospective Review of the Impact on a Regional Health Care System CONCLUSION: In an acute stroke telemedicine system, implementation of a local nurse-led "stroke responder" system resulted in significantly decreased acute stroke metrics for a community hospital within a regional hospital system. 9/10/2018
Neil Patel, Anna Claudia Massolo, Anshuman Paria, Emily J Stenhouse, Lindsey Hunter, Emma Finlay, Carl F Davis Early Postnatal Ventricular Dysfunction Is Associated with Disease Severity in Patients with Congenital Diaphragmatic Hernia CONCLUSIONS: RV and LV function are impaired in the transitional period in infants with CDH. Early LV systolic function correlates with prenatal and postnatal markers of clinical disease severity and may be an important determinant of disease severity and therapeutic target in CDH. These findings su... 9/10/2018
Samuel Estronza, Fanor M Saavedra, Orlando De Jesus, Emil A Pastrana Chordoid Glioma with Psychosis Case Report CONCLUSION: A chordoid glioma is a rare neoplasm that, in 2000, was incorporated into the World Health Organization (WHO) classification of central nervous system tumors. Due to its rarity, it is seldom considered in the differential diagnosis of suprasellar masses. Moreover, its unusual presentatio... 9/7/2018
Jonathan Twu, Neil Patel, Jennifer Moriatis Wolf, Megan Conti Mica Impact of Variation of Corticosteroid Dose, Injection Site, and Multiple Injections on Blood Glucose Measurement in Diabetic Patients CONCLUSIONS: Patients receiving corticosteroid injections in the upper extremity did not experience significant increases in blood glucose whereas those undergoing knee corticosteroid injections demonstrated elevated blood glucose levels. Because poorer glucose control was associated with greater el... 8/6/2018
Chike Ilorah, Brandon Bond, Jorge C Kattah, Bahareh Hassanzadeh An Incidental Finding of Ecchordosis Physaliphora in a Case of Abducens Nerve Palsy Case Report Ecchordosis physaliphora (EP) is a rare non-malignant mass that originates from remains of the notochord and is typically asymptomatic. A 42-year-old man presented with sudden onset of painless horizontal diplopia and his neurological exam showed sixth cranial nerve palsy. Magnetic resonance imaging... 7/26/2018
Vikram Narayan, Andreas Kahlmeyer, Philipp Dahm, Nicole Skoetz, Michael C Risk, Connie Bongiorno, Neil Patel, Eu Chang Hwang, Jae Hung Jung, Gerald Gartlehner, Frank Kunath Pembrolizumab monotherapy versus chemotherapy for treatment of advanced urothelial carcinoma with disease progression during or following platinum-containing chemotherapy A Cochrane Rapid Review BACKGROUND: The use of systemic immunotherapy targets is emerging as an important treatment option for metastatic urothelial carcinoma, particularly for patients who cannot tolerate or who fail cisplatin-based chemotherapy. One such target is the inhibition of the checkpoint protein programmed cell ... 7/24/2018
Cynthia M Chweya, Neil S Patel, William F Young, Bruce E Pollock, Michael J Link, Matthew L Carlson Salvage Radiosurgery After Subtotal Resection for Catecholamine-secreting Jugular Paragangliomas Report of Two Cases and Review of the Literature CONCLUSIONS: Radiosurgery can be used in salvage treatment of catecholamine-secreting JP, providing durable tumor control and resolution of catecholamine excess. For patients with large catecholamine-secreting JP and normal lower cranial nerve function, aggressive nerve-sparing subtotal resection wi... 7/18/2018
Sripal Bangalore, Bora Toklu, Neil Patel, Frederick Feit, Gregg W Stone Newer-Generation Ultrathin Strut Drug-Eluting Stents Versus Older Second-Generation Thicker Strut Drug-Eluting Stents for Coronary Artery Disease CONCLUSIONS: In patients undergoing percutaneous coronary intervention, newer-generation ultrathin strut DES further improve 1-year clinical outcomes in comparison with contemporary thicker strut second-generation DES. 6/28/2018
Stephan A Munich, Marshall C Cress, Leonardo Rangel-Castilla, Ashish Sonig, Chandan Krishna, Elad I Levy, Kenneth V Snyder, Adnan H Siddiqui Use of 4D Computer Tomographic Angiography to Accurately Identify Distal Internal Carotid Artery Occlusions and Pseudo-Occlusions Technical Note CONCLUSION: 4D CTA may be a more effective noninvasive imaging technique than traditional CTA to detect intracranial carotid artery occlusions and carotid artery pseudo-occlusions. Accurate, rapid, and noninvasive diagnosis of carotid artery lesions may help tailor and expedite endovascular interven... 6/21/2018
Hanneke IJsselstijn, Cormac Breatnach, Aparna Hoskote, Anne Greenough, Neil Patel, Irma Capolupo, Francesco Morini, Horst Scharbatke, Florian Kipfmueller, Kjetil Ertresvag, Ulrike Kraemer, Annabella Braguglia, Lucas Wessel, Arno F J van Heijst, Inger Moinichen, Raghnild Emblem, Dick Tibboel, CDH EURO Consortium Group Defining outcomes following congenital diaphragmatic hernia using standardised clinical assessment and management plan SCAMP methodology within the CDH EURO consortium Treatment modalities for neonates born with congenital diaphragmatic hernia (CDH) have greatly improved in recent times with a concomitant increase in survival. In 2008, CDH EURO consortium, a collaboration of a large volume of CDH centers in Western Europe, was established with a goal to standardiz... 6/20/2018
Erik Curtis, Joel R Martin, Brandon Gabel, Nikki Sidhu, Teresa K Rzesiewicz, Ross Mandeville, Sebastiaan Van Gorp, Marjolein Leerink, Takahiro Tadokoro, Silvia Marsala, Catriona Jamieson, Martin Marsala, Joseph D Ciacci A First-in-Human, Phase I Study of Neural Stem Cell Transplantation for Chronic Spinal Cord Injury We tested the feasibility and safety of human-spinal-cord-derived neural stem cell (NSI-566) transplantation for the treatment of chronic spinal cord injury (SCI). In this clinical trial, four subjects with T2-T12 SCI received treatment consisting of removal of spinal instrumentation, laminectomy, a... 6/3/2018
Bahareh Hassanzadeh, Jeffrey DeSanto, Jorge C Kattah Ipilimumab-induced Adenohypophysitis and Orbital Apex Syndrome Importance of Early Diagnosis and Management Ipilimumab is a novel anti-melanoma agent known to infrequently cause multi-organ autoimmunity. We report a case of pituitary hypophysitis and orbital inflammation followed by an orbital apex syndrome. A 64-year-old woman with a history of skin melanoma, receiving ipilimumab treatment, was seen for ... 5/26/2018
Paul M Foreman, Adeel Ilyas, James Mooney, Philip G R Schmalz, Beverly C Walters, Christoph J Griessenauer Antiplatelet Medication Reversal Strategies in Operative Intracranial Hemorrhage A Survey of Practicing Neurosurgeons CONCLUSIONS: When patients on antiplatelet medication present with operative intracranial hemorrhage, the majority of neurosurgeons do not perform qualitative platelet testing. Antiplatelet reversal strategies are significantly influenced by the antiplatelet therapy with more aggressive reversal str... 5/22/2018
Michael A Kohanski, Alan D Workman, Neil N Patel, Li-Yin Hung, Julie P Shtraks, Bei Chen, Mariel Blasetti, Laurel Doghramji, David W Kennedy, Nithin D Adappa, James N Palmer, De'Broski R Herbert, Noam A Cohen Solitary chemosensory cells are a primary epithelial source of IL-25 in patients with chronic rhinosinusitis with nasal polyps CONCLUSIONS: Inflammatory sinus polyps but not adjacent turbinate tissue show expansion of the SCC population, which is the source of epithelial IL-25. 5/21/2018
Arfon Powell, Alexandra Harriet Coxon, Neil Patel, David Chan, Adam Christian, Wyn Lewis Prognostic Significance of Post-Operative Morbidity Severity Score After Potentially Curative D2 Gastrectomy for Carcinoma CONCLUSION: Post-operative CDSC was an important independent prognostic factor after potentially curative gastrectomy for carcinoma associated with both DFS and OS. Prehabilitation strategies to minimize complications are warranted. 5/17/2018
Neil N Patel, Michael A Kohanski, Ivy W Maina, Vasiliki Triantafillou, Alan D Workman, Charles C L Tong, Edward C Kuan, John V Bosso, Nithin D Adappa, James N Palmer, De'Broski R Herbert, Noam A Cohen Solitary chemosensory cells producing interleukin-25 and group-2 innate lymphoid cells are enriched in chronic rhinosinusitis with nasal polyps CONCLUSION: These data support SCC and ILC2 expansion as well as increased IL-25 production in nasal polyps and may represent early events in the pathogenesis of CRSwNP. IL-13 stimulates proliferation of SCC in a feed-forward loop, a process that is steroid-sensitive. 5/10/2018
Terence Verla, Lona Winnegan, Rory Mayer, Jacob Cherian, Nasser Yaghi, Ali Palejwala, Ibrahim Omeis Minimally Invasive Transforaminal Versus Direct Lateral Lumbar Interbody Fusion Effect on Return to Work, Narcotic Use, and Quality of life CONCLUSIONS: Both MIS TLIF and DLIF provide long-term improvement in pain andfunctional outcomes, with an overall reduction in postoperative narcotic requirement. However, there was a significantly longer time to return to work and a greater incidence of reoperation in the TLIF cohort compared with ... 5/9/2018
Christoph J Griessenauer, Christopher S Ogilvy, Nimer Adeeb, Adam A Dmytriw, Paul M Foreman, Hussain Shallwani, Nicola Limbucci, Salvatore Mangiafico, Ashish Kumar, Caterina Michelozzi, Timo Krings, Vitor Mendes Pereira, Charles C Matouk, Mark R Harrigan, Hakeem J Shakir, Adnan H Siddiqui, Elad I Levy, Leonardo Renieri, Thomas R Marotta, Christophe Cognard, Ajith J Thomas Pipeline embolization of posterior circulation aneurysms a multicenter study of 131 aneurysms CONCLUSIONS: In the largest series to date, fusiform aneurysms were found to have the lowest occlusion rate and the highest frequency of major complications. Dissecting aneurysms, frequently treated in the setting of subarachnoid hemorrhage, occluded most often and had a low complication rate. Saccu... 5/5/2018
Shana O Kelley, Nicole M Jackson, Michael G Hill, Jacqueline K Barton Long-Range Electron Transfer through DNA Films Regardless of its position within the DNA film, cross-linked daunomycin (DM) is efficiently reduced electrochemically, indicating that the electron transfer exhibits a shallow distance dependence. Upon the introduction of an intervening cytosine-adenine (CA) mismatch, the electrochemical response is... 5/2/2018
Paul M Foreman, Philipp Hendrix, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Beverly C Walters, R Shane Tubbs, Mohammadali M Shoja, Christoph J Griessenauer PHASES score applied to a prospective cohort of aneurysmal subarachnoid hemorrhage patients The treatment of unruptured intracranial aneurysms remains controversial. The PHASES score was developed to predict the 5-year risk of aneurysm rupture. We have assigned PHASES scores to a cohort of aneurysmal subarachnoid hemorrhage (aSAH) patients to assess the distribution of scores and its abili... 4/25/2018
Neil S Patel, Matthew L Carlson, Bruce E Pollock, Colin L W Driscoll, Brian A Neff, Robert L Foote, Christine M Lohse, Michael J Link Long-term tumor control following stereotactic radiosurgery for jugular paraganglioma using 3D volumetric segmentation OBJECTIVEThe morbidity of gross-total resection of jugular paraganglioma (JP) is often unacceptable due to the potential for irreversible lower cranial neuropathy. Stereotactic radiosurgery (SRS) has been used at the authors' institution since 1990 for the treatment of JP and other benign intracrani... 4/14/2018
Neil D Patel, Patrick M Sullivan, Cheryl M Takao, Sarah Badran, Joseph Ahdoot, Frank F Ing Unmasking the borderline coarctation the utility of isoproterenol in the paediatric cardiac catheterisation laboratory CONCLUSIONS: Isoproterenol can be a useful tool to assess the significance of a coarctation and the effectiveness of an intervention. Percutaneous interventions can effectively reduce the gradients elicited by isoproterenol. 3/15/2018
Adam A Dmytriw, Nimer Adeeb, Ashish Kumar, Christoph J Griessenauer, Kevin Phan, Christopher S Ogilvy, Paul M Foreman, Hussain Shallwani, Nicola Limbucci, Salvatore Mangiafico, Caterina Michelozzi, Timo Krings, Vitor Mendes Pereira, Charles C Matouk, Yuchen Zhang, Mark R Harrigan, Hakeem J Shakir, Adnan H Siddiqui, Elad I Levy, Leonardo Renieri, Christophe Cognard, Ajith J Thomas, Thomas R Marotta Flow Diversion for the Treatment of Basilar Apex Aneurysms CONCLUSION: Flow diversion for the treatment of basilar apex aneurysms results in acceptable occlusion rates in highly selected cases. Both primary flow diversion and rescue after failed clipping or coiling resulted in a modified Rankin Scale score that was either equal or better than at presentatio... 3/13/2018
Stephan A Munich, Marshall C Cress, Leonardo Rangel-Castilla, Ashish Sonig, Christopher S Ogilvy, Giuseppe Lanzino, Ondra Petr, J Mocco, Peter J Morone, Kenneth V Snyder, L Nelson Hopkins, Adnan H Siddiqui, Elad I Levy Neck Remnants and the Risk of Aneurysm Rupture After Endovascular Treatment With Coiling or Stent-Assisted Coiling Much Ado About Nothing CONCLUSION: We found that unruptured aneurysms with residual necks following endovascular treatment posed a very low risk of rupture (0.6%). However, patients presenting with ruptured aneurysms had a higher risk of rerupture from a neck remnant (3.4%). These results highlight the importance of achie... 3/13/2018
Christopher C Dvorak, Prakash Satwani, Elliot Stieglitz, Mitchell S Cairo, Ha Dang, Qinglin Pei, Yun Gao, Donna Wall, Tali Mazor, Adam B Olshen, Joel S Parker, Samir Kahwash, Betsy Hirsch, Susana Raimondi, Neil Patel, Micah Skeens, Todd Cooper, Parinda A Mehta, Stephan A Grupp, Mignon L Loh Disease burden and conditioning regimens in ASCT1221, a randomized phase II trial in children with juvenile myelomonocytic leukemia A Childrens Oncology Group study CONCLUSIONS: The regimen of Bu-Flu is inadequate to provide disease control in patients with JMML who present to HCT with large burdens of disease. Advances in molecular testing may allow better characterization of biologic risk, pre-HCT responses to chemotherapy, and post-HCT management. 3/13/2018
Alexander B Dru, Paul S Kubilis, Gregory A Murad, Tyler Carney, Daniel J Hoh Radiographic and Neurological Outcome After Surgical Treatment of Traumatic Fractures of the Ankylotic Thoracic Spine A Retrospective Case Series CONCLUSION: Presenting fracture alignment does not significantly correlate with pre- or postoperative neurological status. Early posterior stabilization preserved neurological function, with neurological recovery occurring in a portion of individuals. 2/21/2018
Adeel Ilyas, Ching-Jen Chen, Dale Ding, Paul M Foreman, Thomas J Buell, Natasha Ironside, Davis G Taylor, M Yashar Kalani, Min S Park, Andrew M Southerland, Bradford B Worrall Endovascular Mechanical Thrombectomy for Acute Ischemic Stroke Under General Anesthesia Versus Conscious Sedation A Systematic Review and Meta-Analysis CONCLUSIONS: The use of either GA or CS during EMT for patients with anterior circulation acute ELVO does not yield significantly different rates of functional independence at 3 months. 1/23/2018
Tehmeena Khan, Neil Patel Trainee Update, Winter 2017 The Specialist Advisory Committee (SAC) of June 2017 discussed the sign off of procedural competences relating to Sengstaken-Blakemore tube insertion and transvenous cardiac pacing and the application for chief registrar roles. 1/5/2018
Jonathan Labovitz, Neil Patel, Israel Santander Web-Based Patient Experience Surveys to Enhance Response Rates subA Prospective Studysub CONCLUSIONS: We recommend that ambulatory clinics use Web-based technology to administer CAHPS clinician and group surveys, using both e-mail and in-clinic distribution to enhance the response rate. 12/19/2017
Paul M Foreman, Bradford E Jackson, Karan P Singh, Andrew K Romeo, Barton L Guthrie, Winfield S Fisher, Kristen O Riley, James M Markert, Christopher D Willey, Markus Bredel, John B Fiveash Postoperative radiosurgery for the treatment of metastatic brain tumor Evaluation of local failure and leptomeningeal disease In patients undergoing surgical resection of a metastatic brain tumor, whole brain radiation therapy reduces the risk of recurrence and neurologic death. Focal radiation has the potential to mitigate neurocognitive side effects. We present an institutional experience of postoperative radiosurgery fo... 12/18/2017
Arfon G M T Powell, Debora Parkinson, Neil Patel, David Chan, Adam Christian, Wyn G Lewis Prognostic Significance of Serum Inflammatory Markers in Gastric Cancer CONCLUSION: mGPS is an important and only SIR-related prognostic biomarker independently associated with both DFS and OS in gastric cancer. 12/14/2017
Elias Elias, Zeina Nasser, Lona Winegan, Terence Verla, Ibrahim Omeis Bone Morphogenetic Protein Usage in Anterior Lumbar Interbody Fusion What Else Can Go Wrong CONCLUSION: Caution must be exercised while using BMPs because of inadvertent complications. 12/13/2017
Bappaditya Ray, Vijay M Pandav, Eleanor A Mathews, David M Thompson, Lance Ford, Lori K Yearout, Bradley N Bohnstedt, Shuchi Chaudhary, George L Dale, Calin I Prodan Coated-Platelet Trends Predict Short-Term Clinical OutcomeAfter Subarachnoid Hemorrhage Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high socio-economic burden. Prothrombotic states of early brain injury (EBI) and delayed cerebral ischemia (DCI) after aSAH determine morbidity and mortality. To understand how activated platelets might contribute to such prothrombotic sta... 12/11/2017
Alexis Steinberg, Jon C Rittenberger, Maria Baldwin, John Faro, Alexandra Urban, Naoir Zaher, Clifton W Callaway, Jonathan Elmer, Pittsburgh Post-Cardiac Arrest Service Neurostimulant use is associated with improved survival in comatose patients after cardiac arrest regardless of electroencephalographic substrate CONCLUSION: EEG patterns described as ominous after cardiac arrest did not preclude survival or awakening after neurostimulant administration. These data are limited by their observational nature and potential for selection bias, but suggest that EEG patterns alone should not affect consideration of... 12/10/2017
Neil Patel, Adele C Viguera, Ross J Baldessarini Mood-Stabilizing Anticonvulsants, Spina Bifida, and Folate Supplementation Commentary PURPOSE/BACKGROUND: High risks of neural tube defects and other teratogenic effects are associated with exposure in early pregnancy to some anticonvulsants, including in women with bipolar disorder. 12/8/2017
Neil S Patel, Michael J Link, Colin L W Driscoll, Bruce E Pollock, Christine M Lohse, Matthew L Carlson Hearing Outcomes After Stereotactic Radiosurgery for Jugular Paraganglioma CONCLUSION: The short- and intermediate-term risk of progression to nonserviceable hearing following SRS for JP is low. Data regarding the impact of cochlear dose from the vestibular schwannoma literature should not be freely applied to JP, since the impact of SRS parameters on hearing preservation ... 12/2/2017
Milica Vukmanovic-Stejic, Emma S Chambers, Mayte Suárez-Fariñas, Daisy Sandhu, Judilyn Fuentes-Duculan, Neil Patel, Elaine Agius, Katie E Lacy, Carolin T Turner, Anis Larbi, Veronique Birault, Mahdad Noursadeghi, Neil A Mabbott, Malcolm H A Rustin, James G Krueger, Arne N Akbar Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein MAP kinase-induced inflammation CONCLUSION: Excessive inflammation in the skin early after antigen challenge retards antigen-specific immunity. However, this can be reversed by inhibition of inflammatory cytokine production that can be used to promote vaccine efficacy and the treatment of infections and malignancy during aging. 11/21/2017
Jorge C Kattah, Cindy Guede, Bahareh Hassanzadeh The medial vestibular nuclei, a vulnerable target in thiamine deficiency CONCLUSION: This single case study provides clinical-imaging correlation for symmetric MVN compromise in thiamine deficiency, its effect on the VOR gain and the favorable response to thiamine and diet replacement when identified early. 11/17/2017
Fawaz Al-Mufti, Krishna Amuluru, Abhinav Changa, Megan Lander, Neil Patel, Ethan Wajswol, Sarmad Al-Marsoummi, Basim Alzubaidi, I Paul Singh, Rolla Nuoman, Chirag Gandhi Traumatic brain injury and intracranial hemorrhage-induced cerebral vasospasm a systematic review OBJECTIVE Little is known regarding the natural history of posttraumatic vasospasm. The authors review the pathophysiology of posttraumatic vasospasm (PTV), its associated risk factors, the efficacy of the technologies used to detect PTV, and the management/treatment options available today. METHODS... 11/2/2017
Philipp Hendrix, Paul M Foreman, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Minkuan Lin, Beverly C Walters, R Shane Tubbs, Mohammadali M Shoja, Jean-Francois Pittet, Mali Mathru, Christoph J Griessenauer The role of endothelial nitric oxide synthase -786 TC polymorphism in cardiac instability following aneurysmal subarachnoid hemorrhage CONCLUSIONS: The C allele of the eNOS SNP -786 T/C was independently associated with an increased risk for cardiac instability following aSAH. Cardiac instability itself was a risk factor for an unfavorable functional outcome upon discharge from the hospital. 10/29/2017
Neil Patel, Tehmeena Khan Society for Acute Medicine Trainee Update, Autumn 2017 Tehmeena Khan has replaced Sanjay Krishnamoorthy as a Trainee Representative for SAM. We would like to thank Sanjay for all his hard work and contribution during his tenure as Rep. Tehmeena is a final year trainee from North East & Central London. Tehmeena's specialist skills are Leadership, Managem... 10/27/2017
Joel R Martin, Timothy Y Wang, Daniel Loriaux, Rupen Desai, Maragatha Kuchibhatla, Isaac O Karikari, Carlos A Bagley, Oren N Gottfried Race as a predictor of postoperative hospital readmission after spine surgery Hospital readmission after surgery results in a substantial economic burden, and several recent studies have investigated the impact of race and ethnicity on hospital readmission rates, with the goal to identify hospitals and patients with high readmission risk. This single-institution, retrospectiv... 9/13/2017
Philipp Hendrix, Paul M Foreman, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Mingkuan Lin, Beverly C Walters, R Shane Tubbs, Mohammadali M Shoja, Jean-Francois Pittet, Mali Mathru, Christoph J Griessenauer Association of cystathionine beta-synthase polymorphisms and aneurysmal subarachnoid hemorrhage OBJECTIVE Cystathionine β-synthase (CBS) is involved in homocysteine and hydrogen sulfide (H(2)S) metabolism. Both products have been implicated in the pathophysiology of cerebrovascular diseases. The impact of CBS polymorphisms on aneurysmal subarachnoid hemorrhage (aSAH) and its clinical sequelae ... 8/5/2017
Christopher Brown, Tarig Abdelrahman, Neil Patel, Awen Iorwerth, John Pollitt, Mark Holt, Wyn G Lewis Rural Rotations at Core Rarefied Exposure or Real Experience CONCLUSION: CST rotations including rGHs produced a different spectrum of training experience compared with uGH rotations but overall primary outcomes were similar. 7/17/2017
Helen M Segal, Thomas Spatzal, Michael G Hill, Andrew K Udit, Douglas C Rees Electrochemical and structural characterization of Azotobacter vinelandii flavodoxin II Azotobacter vinelandii flavodoxin II serves as a physiological reductant of nitrogenase, the enzyme system mediating biological nitrogen fixation. Wildtype A. vinelandii flavodoxin II was electrochemically and crystallographically characterized to better understand the molecular basis for this funct... 7/16/2017
Michael A Stone, Andre M Jakoi, Justin A Iorio, Martin H Pham, Neil N Patel, Patrick C Hsieh, John C Liu, Frank L Acosta, Raymond Hah, Jeffrey C Wang Bisphosphonates and Intermittent Parathyroid Hormones Effect on Human Spinal Fusion A Systematic Review of the Literature There has been a conscious effort to address osteoporosis in the aging population. As bisphosphonate and intermittent parathyroid hormone (PTH) therapy become more widely prescribed to treat osteoporosis, it is important to understand their effects on other physiologic processes, particularly the im... 7/4/2017
Ande M Jakoi, Gurpal Pannu, Anthony D'Oro, Zorica Buser, Martin H Pham, Neil N Patel, Patrick C Hsieh, John C Liu, Frank L Acosta, Raymond Hah, Jeffrey C Wang The Clinical Correlations between Diabetes, Cigarette Smoking and Obesity on Intervertebral Degenerative Disc Disease of the Lumbar Spine CONCLUSIONS: Diabetes, obesity and cigarette smoking each are significantly associated with an increased diagnosis of lumbar degenerative disc disease. The combination of smoking and obesity had a synergistic effect on increased rates of lumbar degenerative disc disease. Patient education and preven... 7/4/2017
Neil Patel, Florian Kipfmueller Cardiac dysfunction in congenital diaphragmatic hernia Pathophysiology, clinical assessment, and management Cardiac dysfunction is an important consequence of pulmonary hypertension in congenital diaphragmatic hernia and a determinant of disease severity. Increased afterload leads to right ventricular dilatation and diastolic dysfunction. Septal displacement and dysfunction impair left ventricular functio... 6/24/2017
Arvin R Wali, Joel R Martin, Robert Rennert, Daniel K Resnick, William Taylor, Peter Warnke, Clark C Chen Vertebroplasty for vertebral compression fractures Placebo or effective Vertebral compression fractures (VCFs) are a major cause of pain and disability. Here, we reviewed six randomized control trials (RCTs) focusing on the efficacy vs. placebo effect of vertebroplasty (VP) for symptomatic VCF. Four RCTs involved a nonsurgically treated control group. Two RCTs compared ... 6/14/2017
Philipp Hendrix, Paul M Foreman, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Minkuan Lin, Beverly C Walters, R Shane Tubbs, Mohammadali M Shoja, Jean-Francois Pittet, Mali Mathru, Christoph J Griessenauer Association of Plasminogen Activator Inhibitor 1 SERPINE1 Polymorphisms and Aneurysmal Subarachnoid Hemorrhage CONCLUSIONS: SERPINE1 gene polymorphisms were associated with delayed cerebral ischemia and functional outcome after aSAH. These associations may arise from alterations of plasminogen activator inhibitor 1 levels. 6/11/2017
Nimer Adeeb, Christoph J Griessenauer, Apar S Patel, Paul M Foreman, Carlos E Baccin, Justin M Moore, Raghav Gupta, Abdulrahman Alturki, Mark R Harrigan, Christopher S Ogilvy, Ajith J Thomas The Use of Single Stent-Assisted Coiling in Treatment of Bifurcation Aneurysms A Multicenter Cohort Study With Proposal of a Scoring System to Predict Complete Occlusion CONCLUSION: The treatment of bifurcation aneurysm using single stent technique for stent-assisted coiling is safe and effective. Complete occlusion or remnant neck occlusion was achieved in 90.6% of cases. Class III aneurysms can be effectively treated using a single stent, while class I may require... 6/9/2017
Nimer Adeeb, Christoph J Griessenauer, Hussain Shallwani, Hakeem Shakir, Paul M Foreman, Justin M Moore, Adam A Dmytriw, Raghav Gupta, Adnan H Siddiqui, Elad I Levy, Kenneth Snyder, Mark R Harrigan, Christopher S Ogilvy, Ajith J Thomas Pipeline Embolization Device in Treatment of 50 Unruptured Large and Giant Aneurysms CONCLUSIONS: The use of PED for the treatment of large and giant intracranial aneurysms is associated with good occlusion rates, but also a greater complication rate compared to aneurysms of smaller size. There was no significant difference in occlusion rate based on aneurysm shape or size, number o... 6/5/2017
Nimer Adeeb, Christoph J Griessenauer, Paul M Foreman, Justin M Moore, Rouzbeh Motiei-Langroudi, Michelle H Chua, Raghav Gupta, Apar S Patel, Mark R Harrigan, Abdulrahman Y Alturki, Christopher S Ogilvy, Ajith J Thomas Comparison of Stent-Assisted Coil Embolization and the Pipeline Embolization Device for Endovascular Treatment of Ophthalmic Segment Aneurysms A Multicenter Cohort Study CONCLUSION: Stent-coiling and the PED were equally effective for treating OSAs. There were no significant differences in terms of procedural complications, angiographic, functional, and visual outcomes. PED may be more favorable for multiple adjacent OSAs. 6/1/2017
Christoph J Griessenauer, Robert M Starke, Paul M Foreman, Philipp Hendrix, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Mingkuan Lin, Beverly C Walters, Jean-Francois Pittet, Mali Mathru Associations between endothelin polymorphisms and aneurysmal subarachnoid hemorrhage, clinical vasospasm, delayed cerebral ischemia, and functional outcome OBJECTIVE Endothelin-1, a potent vasoconstrictor, and its receptors may be involved in the pathogenesis of aneurysmal subarachnoid hemorrhage (aSAH), clinical vasospasm, delayed cerebral ischemia (DCI), and functional outcome following aSAH. In the present study, common endothelin single nucleotide ... 5/27/2017
Matthew L Carlson, Neil S Patel, Nicole M Tombers, Melissa D DeJong, Alyce I Breneman, Brian A Neff, Colin L W Driscoll Hearing Preservation in Pediatric Cochlear Implantation CONCLUSIONS: Varying levels of hearing preservation with conventional length electrodes can be achieved in most pediatric subjects. In the current study, 82% of patients maintained detectable hearing thresholds and 65% maintained functional low-frequency acoustic hearing. These data may be used to g... 5/25/2017
Mamie Gao, Allen Zhong, Neil Patel, Chiraag Alur, Dinesh Vyas High throughput RNA sequencing utility for diagnosis and prognosis in colon diseases RNA sequencing is the use of high throughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing c... 5/20/2017
Yimo Lin, Rory R Mayer, Terence Verla, Jeffrey S Raskin, Sandi Lam Is there a July effect in pediatric neurosurgery CONCLUSION: For the majority of morbidity and mortality events, no significant difference was found in occurrence rates between the first and last quarters. 5/15/2017
Neil S Patel, Amy C Dearking, Erin K O'Brien, John F Pallanch Virtual Mapping of the Frontal Recess Guiding Safe and Efficient Frontal Sinus Surgery Objective To define relationships between the frontal sinus opening, ostia of other frontal recess cells, and endoscopic landmarks and to develop a clinically useful framework to guide frontal sinus surgery. Study Design Retrospective review. Setting Tertiary care academic referral center. Methods A... 4/19/2017
Joshua Bakhsheshian, Ben A Strickland, Neil N Patel, Andre M Jakoi, Michael Minneti, Gabriel Zada, Frank L Acosta, Patrick C Hsieh, Jeffrey C Wang, John C Liu, Martin H Pham The use of a novel perfusion-based cadaveric simulation model with cerebrospinal fluid reconstitution comparing dural repair techniques a pilot study CONCLUSIONS: We described the feasibility of using a novel cadaveric model for both the study and training of watertight dural closure techniques. 6-0 Prolene was observed to be superior to 4-0 Nurolon for watertight dural closure without a hydrogel sealant. The use of a hydrogel sealant significant... 4/17/2017
Paul M Foreman, Robert M Starke, Philipp Hendrix, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Minkuan Lin, Beverly C Walters, Jean-Francois Pittet, Mali Mathru, Christoph J Griessenauer Endothelin polymorphisms as a risk factor for cerebral aneurysm rebleeding following aneurysmal subarachnoid hemorrhage CONCLUSION: Aneurysm rebleeding following presentation with aSAH was independently associated with the TT genotype of the EDN1 G/T SNP. All patients with acute spontaneous aneurysm rebleeding suffered a poor functional outcome at last follow up. 4/17/2017
Nimer Adeeb, Christoph J Griessenauer, Paul M Foreman, Justin M Moore, Hussain Shallwani, Rouzbeh Motiei-Langroudi, Abdulrahman Alturki, Adnan H Siddiqui, Elad I Levy, Mark R Harrigan, Christopher S Ogilvy, Ajith J Thomas Use of Platelet Function Testing Before Pipeline Embolization Device Placement A Multicenter Cohort Study CONCLUSIONS: Clopidogrel nonresponders experienced a significantly higher rate of thromboembolic complications when compared with clopidogrel responders. However, this risk seems to be mitigated in nonresponders who were switched to ticagrelor or received a clopidogrel boost within 24 hours pre-proc... 4/16/2017
Victoria Kacprzak, Neil A Patel, Elizabeth Riley, Lili Yu, Jing-Ruey J Yeh, Irina V Zhdanova Dopaminergic control of anxiety in young and aged zebrafish Changes in the expression of the dopamine transporter (DAT), or the sensitivity of dopamine receptors, are associated with aging and substance abuse and may underlie some of the symptoms common to both conditions. In this study, we explored the role of the dopaminergic system in the anxiogenic effec... 4/15/2017
Paul M Foreman, Mark R Harrigan Blunt Traumatic Extracranial Cerebrovascular Injury and Ischemic Stroke BACKGROUND: Ischemic stroke occurs in a significant subset of patients with blunt traumatic cerebrovascular injury (TCVI). The patients are victims of motor vehicle crashes, assaults or other high-energy collisions, and suffer ischemic stroke due to injury to the extracranial carotid or vertebral ar... 4/12/2017
A Basit Khan, Emma Hobdy Weiss, Abdul Wali Khan, Ibrahim Omeis, Terence Verla Back Muscle Morphometry Effects on Outcomes of Spine Surgery CONCLUSION: With reduction in surgical complications and improvement in postoperative functional outcomes, back muscle morphometry ought to be included in the preoperative surgical planning as a predictor of outcomes. 4/4/2017
Ruth E Propper, Neil Patel, Stephen D Christman, Christophe Carlei Superior episodic memory in inconsistent-handers a replication and extension using fNIRS A large body of evidence supports the existence of a robust handedness difference in episodic memory retrieval, with inconsistent-handedness being associated with superior memory across a wide variety of paradigms, including superior retrieval of lab-based and real world memories. Despite superior e... 4/1/2017
Charles L Anzalone, Mai Lan Ho, Neil S Patel, Lisa A Schimmenti, Melissa D DeJong, Matthew L Carlson Bilateral Labyrinthine and Internal Auditory Canal Enhancement in an Infant With Severe Labyrinthine Dysplasia A Previously Unreported Phenomenon CONCLUSION: We report a novel presentation and imaging findings of congenital bilateral profound sensorineural hearing loss in a patient with nodular internal auditory canal and labyrinthine enhancement and coexisting inner ear dysplasia. Despite the multiple radiologic abnormalities, the patient ha... 3/28/2017
Philipp Hendrix, Paul M Foreman, Robert M Starke, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Minkuan Lin, Beverly C Walters, R Shane Tubbs, Mohammadali M Shoja, Jean-Francois Pittet, Mali Mathru, Christoph J Griessenauer Associations of Endothelin Polymorphisms and Aneurysm Size at Time of Rupture CONCLUSIONS: The EDNRA SNP rs5335 was independently associated with aneurysms ≥7 mm in size at the time of rupture. Patients with cerebral aneurysms also carrying the G allele of EDNRA SNP rs5335 may develop larger aneurysms before rupture. 3/22/2017
Paul M Foreman, Gregory K Friedman, Kevin A Cassady, James M Markert Oncolytic Virotherapy for the Treatment of Malignant Glioma Malignant glioma is the most common primary brain tumor and carries a grim prognosis, with a median survival of just over 14 months. Given the poor outcomes with standard-of-care treatments, novel treatment strategies are needed. The concept of virotherapy for the treatment of malignant tumors dates... 3/8/2017
Philipp Hendrix, Paul M Foreman, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Minkuan Lin, Beverly C Walters, R Shane Tubbs, Mohammadali M Shoja, Jean-Francois Pittet, Mali Mathru, Christoph J Griessenauer Endothelial Nitric Oxide Synthase Polymorphism Is Associated with Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage CONCLUSIONS: The present study is the first to demonstrate that the C allele of the eNOS SNP 786 T->C rs2070744 is independently associated with an increased risk for delayed cerebral ischemia following aSAH. 3/4/2017
Nimer Adeeb, Christoph J Griessenauer, Justin M Moore, Paul M Foreman, Hussain Shallwani, Rouzbeh Motiei-Langroudi, Raghav Gupta, Carlos E Baccin, Abdulrahman Alturki, Mark R Harrigan, Adnan H Siddiqui, Elad I Levy, Christopher S Ogilvy, Ajith J Thomas Ischemic Stroke After Treatment of Intraprocedural Thrombosis During Stent-Assisted Coiling and Flow Diversion CONCLUSIONS: Current protocols for treatment of intraprocedural thrombosis associated with placement of intra-arterial devices were effective in preventing ischemic stroke in ≈80% of cases. Current smoking was the only independent predictor of ischemic stroke. 3/2/2017
Philipp Hendrix, Paul M Foreman, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Minkuan Lin, Beverly C Walters, R Shane Tubbs, Mohammadali M Shoja, Jean-Francois Pittet, Mali Mathru, Christoph J Griessenauer Impact of High-Mobility Group Box 1 Polymorphism on Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage CONCLUSIONS: The minor allele G of rs2249825 was associated with an increased risk for DCI, or cerebral infarction, after aSAH. This finding may be attributable to an increased HMGB1 protein expression in these patients. 2/13/2017
Hasan A Zaidi, Michael A Mooney, Michael R Levitt, Alexander B Dru, Adib A Abla, Robert F Spetzler Impact of Timing of Intervention Among 397 Consecutively Treated Brainstem Cavernous Malformations CONCLUSIONS: Although BSCM surgery is associated with significant perioperative morbidity and mortality, favorable long-term hemorrhage rates and symptom resolution can be achieved in a carefully selected group of patients. Overall, patients treated acutely, within 6 weeks, benefited the most from s... 2/11/2017
Martin H Pham, Ifije E Ohiorhenuan, Neil N Patel, Andre M Jakoi, Patrick C Hsieh, Frank L Acosta, Jeffrey C Wang, John C Liu A Portable Shoulder-Mounted Camera System for Surgical Education in Spine Surgery The past several years have demonstrated an increased recognition of operative videos as an important adjunct for resident education. Currently lacking, however, are effective methods to record video for the purposes of illustrating the techniques of minimally invasive (MIS) and complex spine surger... 2/10/2017
Jacob B Hunter, Neil S Patel, Brendan P O'Connell, Matthew L Carlson, Neil T Shepard, Devin L McCaslin, George B Wanna Cervical and Ocular VEMP Testing in Diagnosing Superior Semicircular Canal Dehiscence Objective To determine the sensitivity and specificity of ocular and cervical vestibular evoked myogenic potentials (VEMPs) in the diagnosis of superior semicircular canal dehiscence (SCD) and to describe the VEMP response characteristics that are most sensitive to SCD and compare the findings to pr... 2/8/2017
Christoph J Griessenauer, R Shane Tubbs, Paul M Foreman, Michelle H Chua, Nilesh A Vyas, Robert H Lipsky, Mingkuan Lin, Ramaswamy Iyer, Rishikesh Haridas, Beverly C Walters, Salman Chaudry, Aisana Malieva, Samantha Wilkins, Mark R Harrigan, Winfield S Fisher, Mohammadali M Shoja Association of renin-angiotensin system genetic polymorphisms and aneurysmal subarachnoid hemorrhage OBJECTIVE Renin-angiotensin system (RAS) genetic polymorphisms are thought to play a role in cerebral aneurysm formation and rupture. The Cerebral Aneurysm Renin-Angiotensin System (CARAS) study prospectively evaluated common RAS polymorphisms and their relation to aneurysmal subarachnoid hemorrhage... 1/21/2017
Philipp Hendrix, Paul M Foreman, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Minkuan Lin, Beverly C Walters, R Shane Tubbs, Mohammadali M Shoja, Jean-Francois Pittet, Mali Mathru, Christoph J Griessenauer Ryanodine Receptor 1 Polymorphism Is Not Associated with Aneurysmal Subarachnoid Hemorrhage or its Clinical Sequelae CONCLUSIONS: Contrary to a previous report, the RYR1 SNP rs35364374 was not associated with aSAH or its clinical sequelae. 1/15/2017
Theodore J Zwang, Sylvia Hürlimann, Michael G Hill, Jacqueline K Barton Helix-Dependent Spin Filtering through the DNA Duplex Recent work suggests that electrons can travel through DNA and other chiral molecules in a spin-selective manner, but little is known about the origin of this spin selectivity. Here we describe experiments on magnetized DNA-modified electrodes to explore spin-selective electron transport through hyd... 12/10/2016
Satyam Veean, Neil Patel, Daniel Lee, Hoang Vo, Eran Rotem A long-standing external iliac artery pseudoaneurysm in a patient with a history of a failed kidney transplant This is a case of a 66-year-old African American male with history of end stage renal disease due to polycystic disease and failed right kidney transplant. He presents with asymptomatic hematuria, and diagnostic angiography was performed which showed incidental anastomotic site pseudoaneurysm. Our p... 12/7/2016
Brandon C Gabel, Daniel R Cleary, Joel R Martin, Usman Khan, Vivian Snyder, Hoi Sang U Unusual and Rare Locations for Craniopharyngiomas Clinical Significance and Review of the Literature CONCLUSIONS: Craniopharyngiomas are most often located in the suprasellar region. Presentation in sites outside the parasellar region is rare. Among these ectopic sites, the cerebellopontine angle appears to be the most common location. 12/3/2016
Kerstin Bettermann, Julia Slocomb, Vikram Shivkumar, David Quillen, Thomas W Gardner, Mary E Lott Impaired Retinal Vasoreactivity An Early Marker of Stroke Risk in Diabetes Diabetes is a common cause of small vessel disease leading to stroke and vascular dementia. While the function and structure of large cerebral vessels can be easily studied, the brain's microvasculature remains difficult to assess. Previous studies have demonstrated that structural changes in the re... 11/29/2016
Rouzbeh Motiei-Langroudi, Nimer Adeeb, Paul M Foreman, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Beverly C Walters, R Shane Tubbs, Mohammadali M Shoja, Justin M Moore, Raghav Gupta, Christopher S Ogilvy, Ajith J Thomas, Christoph J Griessenauer Predictors of Shunt Insertion in Aneurysmal Subarachnoid Hemorrhage CONCLUSIONS: Sympathomimetic illicit drug use, EVD insertion, and hyponatremia are the strongest predictors of shunt insertion in patients with aSAH. Moreover, a scoring system based on EVD insertion, Hunt and Hess grade, and modified Fisher computed tomography grade can reliably predict the need fo... 11/29/2016
Vivek Singh, Pao Tai Lin, Neil Patel, Hongtao Lin, Lan Li, Yi Zou, Fei Deng, Chaoying Ni, Juejun Hu, James Giammarco, Anna Paola Soliani, Bogdan Zdyrko, Igor Luzinov, Spencer Novak, Jackie Novak, Peter Wachtel, Sylvain Danto, J David Musgraves, Kathleen Richardson, Lionel C Kimerling, Anuradha M Agarwal Mid-infrared materials and devices on a Si platform for optical sensing In this article, we review our recent work on mid-infrared (mid-IR) photonic materials and devices fabricated on silicon for on-chip sensing applications. Pedestal waveguides based on silicon are demonstrated as broadband mid-IR sensors. Our low-loss mid-IR directional couplers demonstrated in SiN (... 11/24/2016
Hermes G Garcia, Marc Otten, Marc Pyfer, Saurabh J Singhal, Alfred Marc Iloreta, Varun R Kshettry, Christopher J Farrell, Gurston Nyquist, Marc Rosen, James J Evans Minimizing Septectomy for Endoscopic Transsphenoidal Approaches to the Sellar and Suprasellar Regions A Cadaveric Morphometric Study The purpose of this study was to evaluate the effect of posterior septectomy size on surgical exposure and surgical freedom during the endoscopic transsphenoidal approach to the sella and parasellar region. Dissections were performed on 10 embalmed cadaver heads. Dissections started with wide bilate... 11/19/2016
Merritt D Kinon, Rani Nasser, Jonathan P Nakhla, Owoicho Adogwa, Jessica R Moreno, Michael Harowicz, Terence Verla, Reza Yassari, Carlos A Bagley Predictive parameters for the antecedent development of hip pathology associated with long segment fusions to the pelvis for the treatment of adult spinal deformity CONCLUSION: This study demonstrates that long segment lumbosacral fusions are not associated with an increase in postoperative hip pathology. Age, gender, BMI, and levels fused do not correlate with the development of postoperative hip pain. The restoration of spinal alignment with long segment fusi... 11/19/2016
Ronak Ved, Neil Patel, Michael Stechman Surgical Management of Life-Threatening Thyroid Haematoma following Occult Blunt Neck Trauma A 42-year-old man arrived at the emergency department in severe respiratory distress, requiring immediate intubation and ventilation. An emergency computed tomography (CT) neck scan identified a substantial haematoma within a multinodular goitre, necessitating an emergency total thyroidectomy. It wa... 11/17/2016
Margaret T Jones, Joel R Martin, Andrew R Jagim, Jonathan M Oliver Effect of Direct Whole-Body Vibration on Upper-Body Muscular Power in Recreational, Resistance-Trained Men Jones, MT, Martin, JR, Jagim, AR, and Oliver, JM. Effect of direct whole-body vibration on upper-body muscular power in recreational, resistance-trained men. J Strength Cond Res 31(5): 1371-1377, 2017-To determine the acute effect of whole-body vibration (WBV) on upper-body power, 15 men (mean ± SD;... 10/28/2016
Apar S Patel, Christoph J Griessenauer, Raghav Gupta, Nimer Adeeb, Paul M Foreman, Hussain Shallwani, Justin M Moore, Mark R Harrigan, Adnan H Siddiqui, Christopher S Ogilvy, Ajith J Thomas Safety and Efficacy of Noncompliant Balloon Angioplasty for the Treatment of Subarachnoid Hemorrhage-Induced Vasospasm A Multicenter Study CONCLUSIONS: Our data suggest that noncompliant balloon angioplasty for treatment of subarachnoid hemorrhage-induced cerebral vasospasm is safe and effective. No predictors of angioplasty success were identified. The rate of delayed cerebral ischemia in territories supplied by vessels that underwent... 10/26/2016
Paul M Foreman, Christoph J Griessenauer, Kimberly P Kicielinski, Philip G R Schmalz, Brandon G Rocque, Matthew R Fusco, Joseph C Sullivan, John P Deveikis, Mark R Harrigan Reliability assessment of the Biffl Scale for blunt traumatic cerebrovascular injury as detected on computer tomography angiography OBJECTIVE Blunt traumatic cerebrovascular injury (TCVI) represents structural injury to a vessel due to high-energy trauma. The Biffl Scale is a widely accepted grading scheme for these injuries that was developed using digital subtraction angiography. In recent years, screening CT angiography (CTA)... 10/22/2016
Neil S Patel, Jacob B Hunter, Brendan P O'Connell, Natalie M Bertrand, George B Wanna, Matthew L Carlson Risk of progressive hearing loss in untreated superior semicircular canal dehiscence CONCLUSION: The risk of progressive hearing loss with observed SSCD is low during short- and intermediate-term follow-up. Further studies are necessary to determine whether late hearing loss occurs. Such information may be critical toward patient counseling regarding the need for and timing of surge... 10/15/2016
Martin H Pham, Alexander Tuchman, Lance Smith, Andre M Jakoi, Neil N Patel, Vivek A Mehta, Frank L Acosta Semitendinosus Graft for Interspinous Ligament Reinforcement in Adult Spinal Deformity Proximal junctional kyphosis is an increasingly recognized complication following long-segment posterior spinal fusion for adult spinal deformity. The authors describe a novel technique for interspinous ligament reinforcement at the proximal adjacent levels using a cadaveric semitendinosus tendon gr... 10/14/2016
Kristen Lew, Nishith Mewada, Sahana Ramanujam, Bahareh Hassanzadeh, John E Donahue, Leema Reddy Peddareddygari, Robert Moser, Charles Kososky, Raji P Grewal Role of Therapeutic Plasma Exchange in Treatment of Tumefactive Multiple Sclerosis-Associated Low CD4 and CD8 Levels We report a 35-year-old healthy male who developed central nervous system inflammatory demyelinating disease consistent with tumefactive multiple sclerosis. About 2 weeks after onset of symptoms and prior to initiation of therapy, the patient had lymphopenia and low CD4 and CD8 levels. His lymphocyt... 10/11/2016
Matthew L Carlson, Nicholas L Deep, Neil S Patel, Larry B Lundy, Nicole M Tombers, Christine M Lohse, Michael J Link, Colin L Driscoll Facial Nerve Schwannomas Review of 80 Cases Over 25 Years at Mayo Clinic CONCLUSION: In patients with FNS, female sex and involvement of the labyrinthine/geniculate and tympanic segments of the facial nerve predict a higher probability of facial paresis or spasm. When isolated to the posterior fossa or parotid gland, establishing a preoperative diagnosis of FNS is challe... 10/11/2016
Catherine Fox, Michael Stewart, Sebastian K King, Neil Patel Acute gastrointestinal compromise in neonates with congenital diaphragmatic hernia prior to repair CONCLUSION: Gastrointestinal compromise is a rare, but potentially catastrophic, complication of CDH. Emergency operative intervention may be required in a select cohort of patients. Early deterioration following birth should alert clinicians to the possibility of significant intestinal pathology. 10/8/2016
Neil S Patel, Kathryn M Van Abel, Michael J Link, Colin L W Driscoll, Jamie J Van Gompel, Brian A Neff, John I Lane, Matthew L Carlson Prevalence and Surgical Implications of Dural Enhancement at the Porus Acusticus in Vestibular Schwannomas CONCLUSION: Dural enhancement is present in approximately 10% of extracanalicular VS. Dural enhancement at the porus acusticus may represent hypervascularity, dural reaction, or infiltration, and portends increased tumor adherence and greater likelihood of subtotal resection to preserve facial nerve... 10/6/2016
Jay Ashok Vachhani, Christopher Michael Nickele, Lucas Elijovich, Paul Klimo, Adam Stephen Arthur Flow Diversion for Treatment of Growing A2 Aneurysm in a Child Case Report and Review of Flow Diversion for Intracranial Aneurysms in Pediatric Patients CONCLUSIONS: Follow-up digital subtraction angiography and magnetic resonance angiography at 6 and 12 months, respectively, showed complete occlusion of the aneurysm. We also reviewed the literature on flow diversion for treatment of pediatric intracranial aneurysms. 10/4/2016
David M McKean, Jason Homsy, Hiroko Wakimoto, Neil Patel, Joshua Gorham, Steven R DePalma, James S Ware, Samir Zaidi, Wenji Ma, Nihir Patel, Richard P Lifton, Wendy K Chung, Richard Kim, Yufeng Shen, Martina Brueckner, Elizabeth Goldmuntz, Andrew J Sharp, Christine E Seidman, Bruce D Gelb, J G Seidman Loss of RNA expression and allele-specific expression associated with congenital heart disease Congenital heart disease (CHD), a prevalent birth defect occurring in 1% of newborns, likely results from aberrant expression of cardiac developmental genes. Mutations in a variety of cardiac transcription factors, developmental signalling molecules and molecules that modify chromatin cause at least... 9/28/2016
Neil D Patel, Andrew Newburn, Michael E Brier, Deepa H Chand Pediatric Hypertension Are Pediatricians Following Guidelines The National Heart, Lung, and Blood Institute recommends that children older than 3 years seen in the medical setting have their blood pressure (BP) measured. The authors aimed to determine whether BPs are measured at well-child visits and whether elevated readings are recognized. A retrospective ch... 9/24/2016
Vandana Batra, Mehran Makvandi, Athena F Zuppa, Neil Patel, Jimmy Elias, Daniel A Pryma, John M Maris Dexmedetomidine does not interfere with meta-iodobenzylguanidine MIBG uptake at clinically relevant concentrations CONCLUSION: We conclude that dexmedetomidine will not interfere with therapeutic [^(131) I]MIBG efficacy. 9/23/2016
Robert A Hirschl, Louis P Caragine Robotic-assisted superficial temporal artery-to-middle cerebral artery anastomosis Robotic-assisted surgery is becoming more prevalent and accepted in the USA and is routine in many medical centers across a variety of specialties, but mainly in urology and general surgery. However, neurosurgery has yet to embrace this new technology. We used the da Vinci(®) robot (Intuitive Surgic... 9/16/2016
Spencer Novak, Pao-Tai Lin, Cheng Li, Nikolay Borodinov, Zhaohong Han, Corentin Monmeyran, Neil Patel, Qingyang Du, Marcin Malinowski, Sasan Fathpour, Chatdanai Lumdee, Chi Xu, Pieter G Kik, Weiwei Deng, Juejun Hu, Anuradha Agarwal, Igor Luzinov, Kathleen Richardson Electrospray Deposition of Uniform Thickness Ge23Sb7S70 and As40S60 Chalcogenide Glass Films Solution-based electrospray film deposition, which is compatible with continuous, roll-to-roll processing, is applied to chalcogenide glasses. Two chalcogenide compositions are demonstrated: Ge23Sb7S70 and As40S60, which have both been studied extensively for planar mid-infrared (mid-IR) microphoton... 9/2/2016
Matthew L Carlson, Katherine A Lees, Neil S Patel, Christine M Lohse, Brian A Neff, Michael J Link, Colin L Driscoll The Clinical Behavior of Asymptomatic Incidental Vestibular Schwannomas Is Similar to That of Symptomatic Tumors CONCLUSION: The frequency of asymptomatic, incidentally diagnosed VS is rising. These data demonstrate that the clinical behavior of asymptomatic incidental VS is not different than that of age-, sex-, and size-matched symptomatic VS. Thus, if initial observation is undertaken, patients with asympto... 8/31/2016
Neil D Patel, Sarah Badran, Grace Kung Anomalous left coronary artery from the pulmonary artery discovered following total anomalous pulmonary venous return repair a rare entity We describe a case of anomalous left coronary artery from the pulmonary artery in association with total anomalous pulmonary venous return. The infant was diagnosed with total anomalous pulmonary venous return at 6 weeks of age and underwent successful surgical repair. On routine follow-up, he was f... 8/31/2016
Patrick Heindel, Alexander Tuchman, Patrick C Hsieh, Martin H Pham, Anthony D'Oro, Neil N Patel, Andre M Jakoi, Ray Hah, John C Liu, Zorica Buser, Jeffrey C Wang Reoperation Rates After Single-level Lumbar Discectomy CONCLUSION: We report an overall 4-year reoperation rate of 12.2% after single-level discectomy. In addition, we report a rate of progression to lumbar fusion following re-exploration discectomy of 38.4% within 4 years of reoperation. Further studies are needed regarding the best treatment algorithm... 8/23/2016
Christoph J Griessenauer, Christopher S Ogilvy, Paul M Foreman, Michelle H Chua, Mark R Harrigan, Lucy He, Matthew R Fusco, J D Mocco, Christopher J Stapleton, Aman B Patel, Ashish Sonig, Adnan H Siddiqui, Ajith J Thomas Pipeline Embolization Device for Small Intracranial Aneurysms Evaluation of Safety and Efficacy in a Multicenter Cohort CONCLUSION: In the largest series on PED for small aneurysms to date, data suggest that treatment with the flow-diverting PED is safe and efficacious, with complication rates comparable to those for traditional endovascular techniques. 8/5/2016
Douglas M Bennion, Christian A Rosado, Emily A Haltigan, Robert W Regenhardt, Colin Sumners, Michael F Waters Serum activity of angiotensin converting enzyme 2 is decreased in patients with acute ischemic stroke Levels of angiotensin converting enzyme 2 (ACE2), a cardio and neuro-protective carboxypeptidase, are dynamically altered after stroke in preclinical models. We sought to characterize the previously unexplored changes in serum ACE2 activity of stroke patients and the mechanism of these changes. Seru... 8/5/2016
Terence Verla, Jared S Fridley, Abdul Basit Khan, Rory R Mayer, Ibrahim Omeis Neuromonitoring for Intramedullary Spinal Cord Tumor Surgery CONCLUSIONS: By using intraoperative somatosensory evoked potentials, transcranial motor evoked potentials, D-waves, and dorsal column mapping, spinal injury could be prevented in most cases, thereby improving postoperative neurologic functioning and outcome in patients undergoing surgery for IMSCT. 7/31/2016
Christoph J Griessenauer, Nimer Adeeb, Paul M Foreman, Raghav Gupta, Apar S Patel, Justin Moore, Thiago G Abud, Ajith J Thomas, Christopher S Ogilvy, Carlos E Baccin Impact of Coil Packing Density and Coiling Technique on Occlusion Rates for Aneurysms Treated with Stent-Assisted Coil Embolization CONCLUSIONS: Aneurysm size remains the most important predictor of aneurysm recanalization and retreatment after stent-assisted coiling. Although higher packing densities were associated with increased rates of aneurysm occlusion in unadjusted statistical comparisons, this finding was no longer sign... 7/13/2016
Ting Lei, Evgenii Belykh, Alexander B Dru, Kaan Yagmurlu, Ali M Elhadi, Peter Nakaji, Mark C Preul Chen Jingrun, Chinas famous mathematician devastated by brain injuries on the doorstep to solving a fundamental mathematical puzzle Chen Jingrun (1933-1996), perhaps the most prodigious mathematician of his time, focused on the field of analytical number theory. His work on Waring's problem, Legendre's conjecture, and Goldbach's conjecture led to progress in analytical number theory in the form of "Chen's Theorem," which he publ... 7/2/2016
Kyle Schoell, Zorica Buser, Andre Jakoi, Martin Pham, Neil N Patel, Patrick C Hsieh, John C Liu, Jeffrey C Wang Postoperative complications in patients undergoing minimally invasive sacroiliac fusion CONCLUSIONS: The results of this study show that minimally invasive SI joint fusion could possibly carry higher risks of complications than previously stated. These findings are useful for physicians and patients when considering treatment for chronic SI joint pain. 6/29/2016
Neil S Patel, Jacob B Hunter, Brendan P O'Connell, George B Wanna, Matthew L Carlson An Easy and Reliable Method to Locate the Dehiscence During Middle Fossa Superior Canal Dehiscence Surgery It is a Cinch CONCLUSIONS: The horizontal distance from the outer cortex of the squama temporalis to the SSCD consistently approximates 1 inch. This easily remembered distance can aid surgeons in locating or confirming the SSCD during middle fossa surgery. 6/28/2016
Daxa M Patel, Paul M Foreman, L Burt Nabors, Kristen O Riley, G Yancey Gillespie, James M Markert Design of a Phase I Clinical Trial to Evaluate M032, a Genetically Engineered HSV-1 Expressing IL-12, in Patients with RecurrentProgressive Glioblastoma Multiforme, Anaplastic Astrocytoma, or Gliosarcoma M032 is a second-generation oncolytic herpes simplex virus (oHSV) that selectively replicates in tumor cells. M032 kills tumor cells directly through oncolytic replication and then proceeds to infect tumor cells in proximity, continuing the process of tumor destruction. In addition to this direct on... 6/18/2016
Leonardo Rangel-Castilla, Stephan A Munich, Naser Jaleel, Marshall C Cress, Chandan Krishna, Ashish Sonig, Kenneth V Snyder, Adnan H Siddiqui, Elad I Levy Patency of anterior circulation branch vessels after Pipeline embolization longer-term results from 82 aneurysm cases OBJECTIVE The Pipeline Embolization Device (PED) has become increasingly used for the treatment of intracranial aneurysms. Given its high metal surface area coverage, there is concern for the patency of branch vessels that become covered by the device. Limited data exist regarding the patency of bra... 6/11/2016
Christoph J Griessenauer, R Shane Tubbs, Paul M Foreman, Michelle H Chua, Nilesh A Vyas, Robert H Lipsky, Mingkuan Lin, Ramaswamy Iyer, Rishikesh Haridas, Beverly C Walters, Salman Chaudry, Aisana Malieva, Samantha Wilkins, Mark R Harrigan, Winfield S Fisher, Mohammadali M Shoja Associations of renin-angiotensin system genetic polymorphisms and clinical course after aneurysmal subarachnoid hemorrhage OBJECTIVE Renin-angiotensin system (RAS) genetic polymorphisms are thought to play a role in cerebral aneurysm formation and rupture. The Cerebral Aneurysm Renin Angiotensin System (CARAS) study prospectively evaluated associations of common RAS polymorphisms and clinical course after aneurysmal sub... 6/11/2016
Robert J Yawn, Neil S Patel, Colin L Driscoll, Michael J Link, David S Haynes, George B Wanna, Reid C Thompson, Matthew L Carlson Primary Epidermoid Tumors of the Cerebellopontine Angle A Review of 47 Cases CONCLUSIONS: Surgical intervention is effective in alleviating symptoms of cranial neuropathy and brainstem compression from CPA epidermoids. Gross total resection is preferred; however, aggressive subtotal removal should be considered with adherent or extensive disease as reoperation rates are low,... 6/9/2016
Terence Verla, Jonathan G Thomas, Vilmos Thomazy, Gregory N Fuller, Aziz Shaibani, Ibrahim Omeis Fulminant spinal cord compression caused by postradiation inflammatory pseudotumor with rapid response to steroids case report Radiation therapy continues to play an extremely valuable role in the treatment of malignancy. The effects of radiation therapy on normal tissue can present in a delayed fashion, resulting in localized damage with pseudomalignant transformation, producing a compressive effect on the spinal cord or e... 5/28/2016
Paul M Foreman, Michelle H Chua, Mark R Harrigan, Winfield S Fisher, R Shane Tubbs, Mohammadali M Shoja, Christoph J Griessenauer External validation of the Practical Risk Chart for the prediction of delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage OBJECTIVE Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) occurs in approximately 30% of patients. The Practical Risk Chart was developed to predict DCI based on admission characteristics; the authors seek to externally validate and critically appraise this predic... 5/14/2016
Neil D Patel, William D Fales, Robert N Farrell The use of a photoionization detector to detect harmful volatile chemicals by emergency personnel CONCLUSIONS: The results of this investigation indicate that the PID may be an effective screening tool for emergency responders. However, additional study is necessary to both confirm the effectiveness of the PID and refine the screening protocol if necessary. 5/6/2016
Peter Abraham, Robert C Rennert, Joel R Martin, Joseph Ciacci, William Taylor, Daniel Resnick, Ekkehard Kasper, Clark C Chen The role of surgery for treatment of low back pain insights from the randomized controlled Spine Patient Outcomes Research Trials Low back pain (LBP) is a common medical problem with high morbidity and healthcare costs. The optimal management strategy, including the role of surgical intervention, remains controversial. The Spine Patient Outcomes Research Trials were randomized controlled studies conducted to assess the effecti... 4/30/2016
Tania V Darnton, Bryan M Hunter, Michael G Hill, Stanislav Záliš, Antonín Vlček, Harry B Gray Reduced and Superreduced Diplatinum Complexes A d(8)-d(8) complex [Pt2(μ-P2O5(BF2)4](4-) (abbreviated Pt(pop-BF2)(4-)) undergoes two 1e(-) reductions at E1/2 = -1.68 and Ep = -2.46 V (vs Fc(+)/Fc) producing reduced Pt(pop-BF2)(5-) and superreduced Pt(pop-BF2)(6-) species, respectively. The EPR spectrum of Pt(pop-BF2)(5-) and UV-vis spectra of b... 4/13/2016
Bryan M Hunter, Jeremy Kallick, Jessica Kissel, Maya Herzig, Cyrus Manuel, Dmitri Protsenko, Brian J F Wong, Michael G Hill Controlled-Potential Electromechanical Reshaping of Cartilage An alternative to conventional "cut-and-sew" cartilage surgery, electromechanical reshaping (EMR) is a molecular-based modality in which an array of needle electrodes is inserted into cartilage held under mechanical deformation by a jig. Brief (ca. 2 min) application of an electrochemical potential ... 4/10/2016
Benjamin J Ditty, Nidal B Omar, Paul M Foreman, Joseph H Miller, Kimberly P Kicielinski, Winfield S Fisher, Mark R Harrigan Seizure outcomes after stereotactic radiosurgery for the treatment of cerebral arteriovenous malformations OBJECTIVE Patients with cerebral arteriovenous malformations (AVMs) commonly present with seizure. Seizure outcomes in patients treated with stereotactic radiosurgery (SRS) are poorly defined. A case series of patients with cerebral AVMs treated with SRS is presented to evaluate long-term seizure ou... 4/9/2016
Enrique F Elli, Raquel Gonzalez-Heredia, Neil Patel, Mario Masrur, Melissa Murphey, Jinsong Chen, Lisa Sanchez-Johnsen Bariatric surgery outcomes in ethnic minorities CONCLUSION: Our primary hypothesis was partially supported, as blacks but not Hispanics had a lower %EWL compared to whites at 6 months. An interesting finding is that blacks had a lower %EWL than Hispanics at every time point. Moreover, our secondary hypothesis was partially supported. Results reve... 4/7/2016
Neil S Patel, Kianoush Sheykholeslami Papillary carcinoma in thyroglossal duct cyst Two case reports and review of the literature The thyroglossal duct cyst is one of the more common congenital anterior neck masses. In rare cases, carcinoma has been detected within one of these cysts on histopathologic analysis of resected tissue. Since the incidence of thyroglossal duct cyst carcinoma is low, the appropriate management of the... 3/19/2016
Gelareh Z Gabayan, Michael K Gould, Robert E Weiss, Neil Patel, Kwame A Donkor, Vicki Y Chiu, Sau C Yiu, Jason P Jones, Jerome R Hoffman, Catherine A Sarkisian Poor Outcomes After Emergency Department Discharge of the Elderly A Case-Control Study CONCLUSION: We found that older patients discharged from the ED with a change in disposition from "admit" to "discharge," cognitive impairment, systolic blood pressure less than 120 mm Hg, and pulse rate greater than 90 beats/min were at increased risk of death or ICU admission shortly after dischar... 3/8/2016
Christoph J Griessenauer, Christopher S Ogilvy, Paul M Foreman, Michelle H Chua, Mark R Harrigan, Christopher J Stapleton, Aman B Patel, Lucy He, Matthew R Fusco, J Mocco, Peter A Winkler, Apar S Patel, Ajith J Thomas Pipeline Embolization Device for small paraophthalmic artery aneurysms with an emphasis on the anatomical relationship of ophthalmic artery origin and aneurysm OBJECTIVE Contemporary treatment for paraophthalmic artery aneurysms includes flow diversion utilizing the Pipeline Embolization Device (PED). Little is known, however, about the potential implications of the anatomical relationship of the ophthalmic artery (OA) origin and aneurysm, especially in sm... 3/5/2016
Rupen Desai, Gautam Nayar, Visakha Suresh, Timothy Y Wang, Daniel Loriaux, Joel R Martin, Oren N Gottfried Independent predictors of mortality following spine surgery We investigated the effect of preoperative patient demographics and operative factors on mortality in the 30day postoperative period after spine surgery. Postoperative mortality from surgical interventions has significantly decreased with progressive improvement in surgical techniques and patient se... 3/2/2016
Matthew L Carlson, Neil S Patel, Amy E Glasgow, Elizabeth B Habermann, Brandon R Grossardt, Michael J Link Vestibular schwannoma and pituitary adenoma in the same patient coincidence or novel clinical association Over the years the authors have evaluated a number of patients with vestibular schwannomas (VS) who have also been diagnosed with a pituitary adenoma (PA). No associations between these tumors have been established to date. The objective of the current study is to investigate the epidemiological ass... 2/24/2016
Nileshkumar Patel, Abhishek Deshmukh, Badal Thakkar, James O Coffey, Kanishk Agnihotri, Achint Patel, Nitesh Ainani, Nikhil Nalluri, Nilay Patel, Nish Patel, Neil Patel, Apurva O Badheka, Marcin Kowalski, Robert Hendel, Juan Viles-Gonzalez, Peter A Noseworthy, Samuel Asirvatham, Kaming Lo, Robert J Myerburg, Raul D Mitrani Gender, Race, and Health Insurance Status in Patients Undergoing Catheter Ablation for Atrial Fibrillation Catheter ablation for atrial fibrillation (AF) has emerged as a popular procedure. The purpose of this study was to examine whether there exist differences or disparities in ablation utilization across gender, socioeconomic class, insurance, or race. Using the Nationwide Inpatient Sample (2000 to 20... 2/23/2016
Paul M Foreman, Michelle Chua, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Beverly C Walters, R Shane Tubbs, Mohammadali M Shoja, Christoph J Griessenauer Association of nosocomial infections with delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage OBJECTIVE Delayed cerebral ischemia (DCI) is a recognized complication of aneurysmal subarachnoid hemorrhage (aSAH) that contributes to poor outcome. This study seeks to determine the effect of nosocomial infection on the incidence of DCI and patient outcome. METHODS An exploratory analysis was perf... 2/13/2016
S Harrison Farber, Jeffrey Hatef, Jing L Han, Andrew H Marky, Jichun Xie, Kevin Huang, Terence Verla, Yuliya Lokhnygina, Timothy A Collins, Shivanand P Lad Implantable Neurostimulation for Headache Disorders Effect on Healthcare Utilization and Expenditures CONCLUSIONS: Our study suggests that implantable neurostimulation reduces healthcare expenditures within a relatively short time period in patients with severe refractory headache. 2/10/2016
Shelby L Hall, Stephan A Munich, Marshall C Cress, Leonardo Rangel-Castilla, Elad I Levy, Kenneth V Snyder, Adnan H Siddiqui Risk of acute kidney injury associated with neuroimaging obtained during triage and treatment of patients with acute ischemic stroke symptoms CONCLUSIONS: This study provides preliminary evidence of the safety and feasibility of obtaining CTSS with additional DSA imaging, whether for diagnosis or intervention, to identify possible acute ischemic stroke. 2/6/2016
Enrique F Elli, Raquel Gonzalez-Heredia, Lisa Sanchez-Johnsen, Neil Patel, Raquel Garcia-Roca, Jose Oberholzer Sleeve gastrectomy surgery in obese patients post-organ transplantation CONCLUSION: Initials results found that there were no significant differences in %EWL or %WL at 6 and 12 months follow-up between transplant and nontransplant patients. There were also no perioperative and postoperative complications among transplant patients after SG. 1/30/2016
Paul M Foreman, Casey J Madura, James M Johnston, Brandon G Rocque Two-stage surgical resection of an atypical teratoid rhabdoid tumor occupying the infratentorial and supratentorial compartment in children under two years Report of two cases CONCLUSION: A staged operative approach appears safe and efficacious when resecting large tumors from both the infratentorial and supratentorial compartments in children less than two years of age. 1/27/2016
Bartley D Mitchell, Terence Verla, Duemani Reddy, Lona Winnegan, Ibrahim Omeis Reliable Intraoperative Repair Nuances of Cerebrospinal Fluid Leak in Anterior Cervical Spine Surgery and Review of the Literature CONCLUSIONS: Once durotomy is encountered during anterior spine surgery, draining the CSF to a low pressure followed by dural substitute with a sealing agent, followed by a smaller anteroposterior size graft is an effective strategy of preventing complications in an inescapable problem. 1/24/2016
Khondoker M Akram, Neil Patel, Monica A Spiteri, Nicholas R Forsyth Lung Regeneration Endogenous and Exogenous Stem Cell Mediated Therapeutic Approaches The tissue turnover of unperturbed adult lung is remarkably slow. However, after injury or insult, a specialised group of facultative lung progenitors become activated to replenish damaged tissue through a reparative process called regeneration. Disruption in this process results in healing by fibro... 1/23/2016
Neil Patel, Samantha J Hodges, Melanie Hall, Philip E Benson, Zoe Marshman, Susan J Cunningham Development of the Malocclusion Impact Questionnaire MIQ to measure the oral health-related quality of life of young people with malocclusion part 1 - qualitative inquiry CONCLUSIONS: Common themes relating to the impact of malocclusion on the lives of young people were identified and generated items for the new MIQ to measure the oral health-related quality of life of young people with malocclusion. Part 2 outlines the further development and testing of the MIQ. 1/10/2016
Martin H Pham, Vivek A Mehta, Neil N Patel, Andre M Jakoi, Patrick C Hsieh, John C Liu, Jeffrey C Wang, Frank L Acosta Complications associated with the Dynesys dynamic stabilization system a comprehensive review of the literature The Dynesys dynamic stabilization system is an alternative to rigid instrumentation and fusion for the treatment of lumbar degenerative disease. Although many outcomes studies have shown good results, currently lacking is a comprehensive report on complications associated with this system, especiall... 1/2/2016
Jarrod D Predina, Jane Keating, Neil Patel, Sarah Nims, Sunil Singhal Clinical implications of positive margins following non-small cell lung cancer surgery Positive margins following pulmonary resection of non-small cell lung cancer (NSCLC) occur in approximately 5-15% of patients undergoing a curative procedure. The presence of positive margins negatively impacts long-term outcomes by setting the stage for local and potentially distant disease recurre... 1/1/2016
Ronak J Naik, Neil R Patel, Ming Wang, Nishant C Shah Infective endocarditis prophylaxis current practice trend among paediatric cardiologists are we following the 2007 guidelines CONCLUSION: Significant heterogeneity still persists in recommending infective endocarditis prophylaxis for several cardiac lesions among paediatric cardiologists. More than half of the participants (56%) do not follow the current guidelines exclusively in their practice. Counselling for optimal ora... 12/31/2015
Christoph J Griessenauer, Mohamed Salem, Philipp Hendrix, Paul M Foreman, Christopher S Ogilvy, Ajith J Thomas Preoperative Embolization of Spinal Tumors A Systematic Review and Meta-Analysis CONCLUSIONS: The rapid evolution of neurointervention and spinal tumor embolization has made scientific inquiry and definitive conclusion on the safety and efficacy of the practice difficult. The data supporting the procedure are fragmented and largely based on a multitude of retrospective studies t... 12/26/2015
Timothy Y Wang, Joel R Martin, Daniel B Loriaux, Rupen Desai, Ronnie L Shammas, Owoicho Adogwa, Jessica Moreno, Maragatha Kuchibhatla, Carlos A Bagley, Isaac O Karikari, Oren N Gottfried Risk Assessment and Characterization of 30-Day Perioperative Myocardial Infarction Following Spine Surgery A Retrospective Analysis of 1346 Consecutive Adult Patients CONCLUSION: The present study demonstrates a low incidence of MI after elective surgery with a higher incidence after emergent spine surgery and identifies patient factors predictive of postoperative MI. 12/24/2015
Paul M Foreman, Robert P Naftel, Thomas A Moore, Mark N Hadley The lateral extracavitary approach to the thoracolumbar spine a case series and systematic review CONCLUSIONS: The LECA provides dorsal and unilateral ventrolateral access to and exposure of the thoracolumbar spine and spinal cord while allowing for posterior instrumentation through the same incision. Although excellent neurological results can be expected, the risk of pulmonary complications sh... 12/20/2015
Stephan A Munich, Shelby L Hall, Marshall C Cress, Leonardo Rangel-Castilla, Kenneth V Snyder, L Nelson Hopkins, Adnan H Siddiqui, Elad I Levy To Treat or Not to Treat M2 Occlusions The Question and Answer From a Single Institution CONCLUSION: The results of our single-institution experience suggest that endovascular therapy for M2 occlusions is safe and effective. Additional evaluation with randomized, controlled studies is warranted. 12/17/2015
Jeremy Kallick, Sarah Harris, Andrew K Udit, Michael G Hill Heterogeneous catalysis for azide-alkyne bioconjugation in solution via spin column Attachment of dyes and saccharides to peptides and DNA Copper-catalyzed azide-alkyne cycloaddition (CuAAC) "click" chemistry is widely used and has demonstrated particular utility for bio-orthogonal conjugation reactions. Here we describe a one-pot, heterogeneous bioconjugation and purification method for selectively activated CuAAC. A Cu(II) precursor,... 12/15/2015
Frank W Petraglia, S Harrison Farber, Robert Gramer, Terence Verla, Frances Wang, Steven Thomas, Beth Parente, Shivanand P Lad The Incidence of Spinal Cord Injury in Implantation of Percutaneous and Paddle Electrodes for Spinal Cord Stimulation CONCLUSION: Our study shows that the overall incidence of SCI in SCS is low (2.13%), supporting that SCS is a safe procedure. No significant difference was found in the rates of SCI or spinal hematoma between the percutaneous and paddle groups. Further studies are needed to characterize the mechanis... 12/9/2015
Terence Verla, Owoicho Adogwa, Aladine Elsamadicy, Jessica R Moreno, Harrison Farber, Joseph Cheng, Carlos A Bagley Effects of Psoas Muscle Thickness on Outcomes of Lumbar Fusion Surgery CONCLUSIONS: This study shows that the psoas muscle can be beneficial in overall postoperative rehabilitation with early ambulation and greater improvement in functional outcomes. Given the role of the psoas muscle in spinal stabilization, the effect of psoas muscle thickness on postoperative functi... 12/2/2015
Paul M Foreman, Christoph J Griessenauer, Magdy H Selim, David Eric C Searls, Adnan Safdar, Ekkehard M Kasper, Christopher S Ogilvy, Ajith J Thomas Sexual activity as a trigger for intracranial hemorrhage CONCLUSIONS: Sexual-activity-related ICH is rare and includes various etiologies. The human sexual response in associated with dramatic increases in arterial blood pressure, which likely underlies the association. 11/22/2015
Frank W Petraglia, S Harrison Farber, Jing L Han, Terence Verla, John Gallis, Yuliya Lokhnygina, Beth Parente, Patrick Hickey, Dennis A Turner, Shivanand P Lad Comparison of Bilateral vs Staged Unilateral Deep Brain Stimulation DBS in Parkinsons Disease in Patients Under 70 Years of Age CONCLUSION: Our study did not find a significant difference between 90-day postoperative complication rates or annualized cost between the staged and simultaneous cohorts. Thus, we believe that it is important to consider other factors when deciding between the staged and simultaneous DBS. Such fact... 11/17/2015
Terence Verla, Owoicho Adogwa, Ulysses Toche, S Harrison Farber, Frank Petraglia, Kelly R Murphy, Steven Thomas, Parastou Fatemi, Oren Gottfried, Carlos A Bagley, Shivanand P Lad Impact of Increasing Age on Outcomes of Spinal Fusion in Adult Idiopathic Scoliosis CONCLUSIONS: In this study, age was associated with increased risk of hemorrhage, PE, infection, and refusion. With the aging population, the role of patient age on postoperative healing and outcomes deserves deeper investigation after repair of adult idiopathic scoliosis. 11/8/2015
Wenjun Zhong, James A Feinstein, Neil S Patel, Dingwei Dai, Chirs Feudtner Tall Man lettering and potential prescription errors a time series analysis of 42 childrens hospitals in the USA over 9years CONCLUSIONS: Implementation of Tall Man lettering in 2007 was not associated with a reduction in the potential LA-SA error rate. Whether Tall Man lettering is effective in clinical practice warrants further study. 11/5/2015
Shadi Yaghi, Amelia K Boehme, Jamil Dibu, Christopher R Leon Guerrero, Syed Ali, Sheryl Martin-Schild, Kara A Sands, Ali Reza Noorian, Christina A Blum, Shuchi Chaudhary, Lee H Schwamm, David S Liebeskind, Randolph S Marshall, Joshua Z Willey Treatment and Outcome of Thrombolysis-Related Hemorrhage A Multicenter Retrospective Study CONCLUSIONS AND RELEVANCE: In this study, treatment of postthrombolysis sICH did not significantly reduce the likelihood of in-hospital mortality or hematoma expansion. Shortening the time to diagnosis and treatment may be a key variable in improving outcomes of patients with sICH. 10/27/2015
Neil S Patel, Mara C Modest, Tyler D Brobst, Matthew L Carlson, Daniel L Price, Eric J Moore, Jeffrey R Janus Surgical management of lateral skull base defects CONCLUSION: Advanced tumors that require adjuvant therapy, revision cases for recurrent disease, and cases involving auriculectomy warrant free flap or PMMF reconstruction, with the latter preferred in poor free flap candidates. 10/16/2015
Paul M Foreman, Michelle Chua, Mark R Harrigan, Winfield S Fisher, R Shane Tubbs, Mohammadali M Shoja, Christoph J Griessenauer Antifibrinolytic therapy in aneurysmal subarachnoid hemorrhage increases the risk for deep venous thrombosis A case-control study CONCLUSION: Short course (<48 h) administration of EACA in patients with aneurysmal subarachnoid hemorrhage is associated with an 8.5 times greater risk of DVT formation. 9/18/2015
Paul M Foreman, Mark R Harrigan, Christoph J Griessenauer, Marios Loukas, R Shane Tubbs Access to the carotid artery bifurcation Cadaveric study with application to nasotracheal intubation as a technique to improve access to a high carotid artery bifurcation Carotid endarterectomy (CEA) is a common and efficacious surgical procedure for the prevention of ischemic stroke due to atherosclerosis of the internal carotid artery (ICA). A high common carotid artery bifurcation can make CEA technically difficult due to limited carotid artery exposure. A cadaver... 8/28/2015
Leonardo Rangel-Castilla, Marshall C Cress, Stephan A Munich, Ashish Sonig, Chandan Krishna, Eugene Y Gu, Kenneth V Snyder, L Nelson Hopkins, Adnan H Siddiqui, Elad I Levy Feasibility, Safety, and Periprocedural Complications of Pipeline Embolization for Intracranial Aneurysm Treatment Under Conscious Sedation University at Buffalo Neurosurgery Experience CONCLUSION: In our experience, CS for PED placement for intracranial aneurysm treatment is feasible and safe. Procedure and fluoroscopy times and amount of radiation exposure are similar to or less than described in reports of PED placement under general anesthesia. CS allows direct neurological eva... 8/19/2015
Lindsey E Romick-Rosendale, Anne Legomarcino, Neil B Patel, Ardythe L Morrow, Michael A Kennedy Prolonged antibiotic use induces intestinal injury in mice that is repaired after removing antibiotic pressure implications for empiric antibiotic therapy Metabolic profiling of urine and fecal extracts, histological investigation of intestinal ilea, and fecal metagenomics analyses were used to investigate effects of prolonged antibiotic use in mice. The study provides insight into the effects of extended empiric antibiotic therapy in humans. Mice wer... 8/15/2015
Richard H Epstein, Franklin Dexter, Neil Patel Influencing Anesthesia Provider Behavior Using Anesthesia Information Management System Data for Near Real-Time Alerts and Post Hoc Reports In this review article, we address issues related to using data from anesthesia information management systems (AIMS) to deliver near real-time alerts via AIMS workstation popups and/or alphanumeric pagers and post hoc reports via e-mail. We focus on reports and alerts for influencing the behavior o... 8/12/2015
Nikolay Borodinov, James Giammarco, Neil Patel, Anuradha Agarwal, Katie R O'Donnell, Courtney J Kucera, Luiz G Jacobsohn, Igor Luzinov Stability of Grafted Polymer Nanoscale Films toward Gamma Irradiation The present article focuses on the influence of gamma irradiation on nanoscale polymer grafted films and explores avenues for improvements in their stability toward the ionizing radiation. In terms of applications, we concentrate on enrichment polymer layers (EPLs), which are polymer thin films empl... 8/11/2015
Christoph J Griessenauer, Paul M Foreman, John P Deveikis, Mark R Harrigan Optical coherence tomography of traumatic aneurysms of the internal carotid artery report of 2 cases The pathophysiology of extracranial traumatic aneurysm formation has not been fully elucidated. Intraarterial optical coherence tomography (OCT), an imaging modality capable of micrometer cross-sectional resolution, was used to evaluate patients presenting with saccular traumatic aneurysms of the in... 8/8/2015
Geoffrey W Siegel, Neil N Patel, Michael A Milshteyn, David Buzas, Daniel J Lombardo, Lawrence G Morawa Cost Analysis and Surgical Site Infection Rates in Total Knee Arthroplasty Comparing Traditional vs Single-Use Instrumentation Surgical site infections (SSIs) are a significant complications in total knee arthroplasty (TKA). The purpose of this study was to evaluate if traditional vs. single-use instrumentation had an effect on SSI's. We compared SSI rates and costs of TKAs performed with single-use (449) and traditional (1... 8/2/2015
Nileshkumar J Patel, Aashay Patel, Kanishk Agnihotri, Dhaval Pau, Samir Patel, Badal Thakkar, Nikhil Nalluri, Deepak Asti, Ritesh Kanotra, Sabeeda Kadavath, Shilpkumar Arora, Nilay Patel, Achint Patel, Azfar Sheikh, Neil Patel, Apurva O Badheka, Abhishek Deshmukh, Hakan Paydak, Juan Viles-Gonzalez Prognostic impact of atrial fibrillation on clinical outcomes of acute coronary syndromes, heart failure and chronic kidney disease Atrial fibrillation (AF) is the most common type of sustained arrhythmia, which is now on course to reach epidemic proportions in the elderly population. AF is a commonly encountered comorbidity in patients with cardiac and major non-cardiac diseases. Morbidity and mortality associated with AF makes... 7/31/2015
Rohit Divekar, Neil Patel, Jay Jin, John Hagan, Matthew Rank, Devyani Lal, Hirohito Kita, Erin O'Brien Symptom-Based Clustering in Chronic Rhinosinusitis Relates to History of Aspirin Sensitivity and Postsurgical Outcomes CONCLUSION: Symptom-based clusters in CRS reveal a distinct grouping of symptom burden that may relate to aspirin sensitivity and treatment outcomes. 7/29/2015
Paul M Foreman, Christoph J Griessenauer, Michelle Chua, Mark N Hadley, Mark R Harrigan Corrective spinal surgery may be protective against stroke in patients with blunt traumatic vertebral artery occlusion OBJECT Approximately 10% of patients with blunt traumatic extracranial cerebrovascular injury have a complete occlusion of the vertebral artery (VA). Ischemic stroke due to embolization of thrombus from an occluded VA following cervical spine surgery has been observed. The risk of ischemic stroke wi... 7/18/2015
Timothy Y Wang, Jeffrey T Sakamoto, Gautam Nayar, Visakha Suresh, Daniel B Loriaux, Rupen Desai, Joel R Martin, Owoicho Adogwa, Jessica Moreno, Carlos A Bagley, Isaac O Karikari, Oren N Gottfried Independent Predictors of 30-Day Perioperative Deep Vein Thrombosis in 1346 Consecutive Patients After Spine Surgery CONCLUSIONS: This study identifies patient factors predictive of postoperative DVT. Postoperative DVT prophylaxis may be warranted for patients undergoing emergent spine surgery because these patients have significantly higher risk of developing postoperative DVT. 7/15/2015
Azfar Sheikh, Nileshkumar J Patel, Nikhil Nalluri, Kanishk Agnihotri, Jonathan Spagnola, Aashay Patel, Deepak Asti, Ritesh Kanotra, Hafiz Khan, Chirag Savani, Shilpkumar Arora, Nilay Patel, Badal Thakkar, Neil Patel, Dhaval Pau, Apurva O Badheka, Abhishek Deshmukh, Marcin Kowalski, Juan Viles-Gonzalez, Hakan Paydak Trends in hospitalization for atrial fibrillation epidemiology, cost, and implications for the future Atrial fibrillation (AF) is the most prevalent arrhythmia worldwide and the most common arrhythmia leading to hospitalization. Due to a substantial increase in incidence and prevalence of AF over the past few decades, it attributes to an extensive economic and public health burden. The increasing nu... 7/12/2015
Raquel Gonzalez-Heredia, Neil Patel, Lisa Sanchez-Johnsen, Mario Masrur, Melissa Murphey, Jinsong Chen, Enrique Elli Does Age Influence Bariatric Surgery Outcomes Aim: The purpose of this study was to evaluate presurgical comorbidities, perioperative and postoperative complications, and postsurgical outcomes of minimally invasive bariatric surgery in patients aged 55 years and older to determine if age should be used as a selection criteria for bariatric surg... 7/9/2015
Carter M Suryadevara, Patrick C Gedeon, Luis Sanchez-Perez, Terence Verla, Christopher Alvarez-Breckenridge, Bryan D Choi, Peter E Fecci, John H Sampson Are BiTEs the missing link in cancer therapy Conventional treatment for cancer routinely includes surgical resection and some combination of chemotherapy and radiation. These approaches are frequently accompanied by unintended and highly toxic collateral damage to healthy tissues, which are offset by only marginal prognostic improvements in pa... 7/9/2015
Milliette Alvarado, Margarita Ramirez, Liurka Lopez, Maria J Marcos-Martinez, Fanor M Saavedra, Juan C Negron-Rivei, Marielba Agosto, Meliza Martinez, Rafael Gonzalez, Myriam Allende-Vigo UNCOMMON PRESENTATION OF FOLLICULAR THYROID CARCINOMA WHEN CHRONIC BACK PAIN SHOULD RAISE A FLAG Follicular thyroid carcinoma is the second most common type of thyroid cancer, and its incidence has increased dramatically in recent years. Although it typically presents as a thyroid nodule, it can spread to distant sites via hematogenous dissemination. Spinal cord compression complicating thyroid... 7/8/2015
Matthew L Carlson, Neil S Patel, Mara C Modest, Eric J Moore, Jeffrey R Janus, Kerry D Olsen Occult Temporal Bone Facial Nerve Involvement by Parotid Malignancies with Perineural Spread CONCLUSIONS: Perineural invasion of the intratemporal FN by parotid malignancy is uncommon. Normal preoperative FN function does not preclude histopathologic involvement. Temporal bone FN exploration should be considered when a positive margin is encountered at the stylomastoid foramen, as failure t... 7/2/2015
Fahim Atif, Neil R Patel, Seema Yousuf, Donald G Stein The Synergistic Effect of Combination Progesterone and Temozolomide on Human Glioblastoma Cells Glioblastoma multiforme (GBM) is the most common and most aggressive malignant brain tumor. Despite optimal treatment and evolving standard of care, the median survival of patients diagnosed with GBM is only 12-15 months. In this study, we combined progesterone (PROG) and temozolomide (TMZ), a stand... 6/26/2015
Zornitza Stark, Joanna Behrsin, Trent Burgess, Anna Ritchie, Alison Yeung, Tiong Y Tan, Natasha J Brown, Ravi Savarirayan, Neil Patel SNP microarray abnormalities in a cohort of 28 infants with congenital diaphragmatic hernia Chromosomal abnormalities are an important factor in the pathogenesis of congenital diaphragmatic hernia (CDH), a relatively common congenital defect associated with high morbidity and mortality. The adoption of array-based platforms for chromosome analysis has resulted in the identification of nume... 6/11/2015
Ariel L Furst, Michael G Hill, Jacqueline K Barton A Multiplexed, Two-Electrode Platform for Biosensing Based on DNA-Mediated Charge Transport We have developed a thin layer, multiplexed biosensing platform that features two working-electrode arrays for detecting small molecules, nucleic acid sequences, and DNA-binding proteins. DNA duplexes are patterned onto the primary electrode array, while a secondary electrode array is used both to i... 6/5/2015
Nicholas J Lennemann, Madeline Walkner, Abigail R Berkebile, Neil Patel, Wendy Maury The Role of Conserved N-Linked Glycans on Ebola Virus Glycoprotein 2 CONCLUSIONS: Our findings support the importance of the GP2 glycans in GP expression/structure, transduction efficiency, and antibody neutralization, particularly when N-linked glycans are also removed from GP1. 6/4/2015
Brian R Lindman, Jared G Breyley, Joel D Schilling, Anna M Vatterott, Alan Zajarias, Hersh S Maniar, Ralph J Damiano, Marc R Moon, Jennifer S Lawton, Brian F Gage, Marc A Sintek, Alejandro Aquino, Christopher L Holley, Neil M Patel, Cassandra Lawler, John M Lasala, Eric Novak Prognostic utility of novel biomarkers of cardiovascular stress in patients with aortic stenosis undergoing valve replacement CONCLUSIONS: These findings demonstrate the potential utility of multiple biomarkers to aid in risk stratification of patients with AS. Further studies are needed to evaluate their utility in clinical decision-making in specific AS populations. 6/4/2015
Sidakpal S Panaich, Apurva O Badheka, Shilpkumar Arora, Nileshkumar J Patel, Badal Thakkar, Nilay Patel, Vikas Singh, Ankit Chothani, Abhishek Deshmukh, Kanishk Agnihotri, Sunny Jhamnani, Sopan Lahewala, Sohilkumar Manvar, Vinaykumar Panchal, Achint Patel, Neil Patel, Parth Bhatt, Chirag Savani, Jay Patel, Ghanshyambhai T Savani, Shantanu Solanki, Samir Patel, Amir Kaki, Tamam Mohamad, Mahir Elder, Ashok Kondur, Michael Cleman, John K Forrest, Theodore Schreiber, Cindy Grines Variability in utilization of drug eluting stents in United States Insights from nationwide inpatient sample CONCLUSION: There is significant between-hospital variation in DES utilization and a higher annual hospital volume is associated with higher utilization rate of DES. © 2015 Wiley Periodicals, Inc. 6/3/2015
Neil Patel, John Belcher, Gary Thorpe, Nicholas R Forsyth, Monica A Spiteri Measurement of C-reactive protein, procalcitonin and neutrophil elastase in saliva of COPD patients and healthy controls correlation to self-reported wellbeing parameters CONCLUSIONS: CRP, PCT and NE were reliably and reproducibly measured in saliva, providing clinically-relevant information on health status in COPD; additionally NE distinguished smoking status. All 3 salivary biomarkers increased during COPD exacerbations, with CRP and PCT correlating well with pati... 5/29/2015
Stephan A Munich, Marshall C Cress, Leonardo Rangel-Castilla, Chandan Krishna, Adnan H Siddiqui, Kenneth V Snyder Importance of repeat angiography in the diagnosis of iatrogenic anterior cerebral artery territory pseudoaneurysm following endoscopic sinus surgery Iatrogenic intracranial pseudoaneurysm formation and rupture are rare complications following endoscopic sinus surgery. Given the propensity for devastating neurologic injury after a relatively routine procedure, swift diagnosis and treatment is essential. The authors present a patient who experienc... 5/22/2015
Apurva O Badheka, Vikas Singh, Nileshkumar J Patel, Shilpkumar Arora, Nilay Patel, Badal Thakkar, Sunny Jhamnani, Sadip Pant, Ankit Chothani, Conrad Macon, Sidakpal S Panaich, Jay Patel, Sohilkumar Manvar, Chirag Savani, Parth Bhatt, Vinaykumar Panchal, Neil Patel, Achint Patel, Darshan Patel, Sopan Lahewala, Abhishek Deshmukh, Tamam Mohamad, Abeel A Mangi, Michael Cleman, John K Forrest Trends of Hospitalizations in the United States from 2000 to 2012 of Patients gt;60 Years With Aortic Valve Disease In recent years, there has been an increased emphasis on the diagnosis and treatment of valvular heart disease and, in particular, aortic stenosis. This has been driven in part by the development of innovative therapeutic options and by an aging patient population. We hypothesized an increase in the... 5/19/2015
Stephan A Munich, Marshall C Cress, Leonardo Rangel-Castilla, Chandan Krishna, Adnan H Siddiqui, Kenneth V Snyder Importance of repeat angiography in the diagnosis of iatrogenic anterior cerebral artery territory pseudoaneurysm following endoscopic sinus surgery Iatrogenic intracranial pseudoaneurysm formation and rupture are rare complications following endoscopic sinus surgery. Given the propensity for devastating neurologic injury after a relatively routine procedure, swift diagnosis and treatment is essential. The authors present a patient who experienc... 5/17/2015
Andrew T Healy, Prasath Mageswaran, Daniel Lubelski, Benjamin P Rosenbaum, Virgilio Matheus, Edward C Benzel, Thomas E Mroz Thoracic range of motion, stability, and correlation to imaging-determined degeneration OBJECT The degenerative process of the spinal column results in instability followed by a progressive loss of segmental motion. Segmental degeneration is associated with intervertebral disc and facet changes, which can be quantified. Correlating this degeneration with clinical segmental motion has n... 5/16/2015
Neil Patel, Amanda Crider, Chirayu D Pandya, Anthony O Ahmed, Anilkumar Pillai Altered mRNA Levels of Glucocorticoid Receptor, Mineralocorticoid Receptor, and Co-Chaperones FKBP5 and PTGES3 in the Middle Frontal Gyrus of Autism Spectrum Disorder Subjects Although stress has been implicated in the pathophysiology of autistic spectrum disorder (ASD), it is not known whether glucocorticoid receptor (GR) levels are altered in the brain of subjects with ASD. The messenger RNA (mRNA) levels of GR isoforms (GRα, GRβ, GRγ, and GRP), mineralocorticoid recept... 4/28/2015
Leonardo Rangel-Castilla, Sirin Gandhi, Stephan A Munich, Marshall C Cress, Ashish Sonig, Chandan Krishna, L Nelson Hopkins, Kenneth V Snyder, Elad I Levy, Adnan H Siddiqui Experience with vertebral artery origin stenting and ostium dilatation results of treatment and clinical outcomes CONCLUSIONS: Safety and feasibility were demonstrated using the Ostial Flash system for VAO stenting and angioplasty. No permanent perioperative complications were seen. 4/4/2015
Raquel Gonzalez-Heredia, Veronica Tirado, Neil Patel, Mario Masrur, Melissa Murphey, Enrique Elli Is emHelicobacter Pyloriem Associated with an Increased Complication Rate after Sleeve Gastrectomy Introduction: Few studies have reported the prevalence and consequences of infection with Helicobacter pylori among obese patients undergoing sleeve gastrectomy. This study reviewed whether infection with H. pylori has any association with postoperative complications. This study also examined whethe... 4/2/2015
Jianli Wang, Qing X Yang, Xiaoyu Sun, Jeffrey Vesek, Zachary Mosher, Megha Vasavada, Jonathan Chu, Sangam Kanekar, Vikram Shivkumar, Kala Venkiteswaran, Thyagarajan Subramanian MRI evaluation of asymmetry of nigrostriatal damage in the early stage of early-onset Parkinsons disease CONCLUSION: Transverse relaxation mapping and DTI demonstrated significant differences between the symptomatic and non-symptomatic hemispheres at the early stage of early-onset PD. These findings support the hypothesis of asymmetric neurodegeneration in the bilateral nigrostriatal pathways in the ea... 4/1/2015
Kiran K Mallula, Neil D Patel, Ra-id Abdulla, John W Bokowski Tetralogy of Fallot with left superior vena cava and coronary sinus atrial septal defect a rare association This report describes a rare case of Tetralogy of Fallot with associated left superior vena cava and coronary sinus atrial septal defect. The initial diagnosis was made by echocardiography. The patient underwent complete repair at 2 months of age. Her postoperative course was complicated by low card... 3/13/2015
Milica Vukmanovic-Stejic, Daisy Sandhu, Judith A Seidel, Neil Patel, Toni O Sobande, Elaine Agius, Sarah E Jackson, Judilyn Fuentes-Duculan, Mayte Suárez-Fariñas, Neil A Mabbott, Katie E Lacy, Graham Ogg, Frank O Nestle, James G Krueger, Malcolm H A Rustin, Arne N Akbar The Characterization of Varicella Zoster Virus-Specific T Cells in Skin and Blood during Aging Reactivation of the varicella zoster virus (VZV) increases during aging. Although the effects of VZV reactivation are observed in the skin (shingles), the number and functional capacity of cutaneous VZV-specific T cells have not been investigated. The numbers of circulating IFN-γ-secreting VZV-speci... 3/4/2015
Carter M Suryadevara, Terence Verla, Luis Sanchez-Perez, Elizabeth A Reap, Bryan D Choi, Peter E Fecci, John H Sampson Immunotherapy for malignant glioma Malignant gliomas (MG) are the most common type of primary malignant brain tumor. Most patients diagnosed with glioblastoma (GBM), the most common and malignant glial tumor, die within 12-15 months. Moreover, conventional treatment, which includes surgery followed by radiation and chemotherapy, can ... 2/28/2015
Neil Patel, Pauline Jones, Vikki Adamson, Monica Spiteri, Kathryn Kinmond Chronic Obstructive Pulmonary Disease Patients Experiences of an Enhanced Self-Management Model of Care Chronic obstructive pulmonary disease (COPD) is debilitating and costly. Self-management is championed to empower individuals to better manage their condition and also to efficiently utilize health resources. As a multi-disciplinary team, we conducted focus group research with individuals living wit... 2/26/2015
Neil B Patel, M Francesca Monn, Clinton D Bahler, Chandru P Sundaram Risk factors associated with 30 day hospital readmission following partial nephrectomy CONCLUSIONS: Patients developing high grade complications are at increased risk of subsequent unplanned readmission. These patients who develop significant in-hospital complications may benefit from increased post-discharge contact with healthcare providers and from preoperative counseling regarding... 2/20/2015
Neil Patel, Rich Branson, Michael Salter, Sheryl Henkel, Roger Seeton, Muzna Khan, Daneshvari Solanki, Aristides Koutrouvelis, Husong Li, Alex Indrikovs, Michael P Kinsky Intrathoracic Pressure Regulation Augments Stroke Volume and Ventricular Function in Human Hemorrhage Obtaining intravenous (i.v.) access for fluid administration is a critical step in treating hemorrhage. However, expertise, supplies, and personnel to accomplish this task can be delayed or even absent in austere environments. An alternative approach that can "buy time" and improve circulation when ... 2/19/2015
Kenneth R Kaufman, Arnaldo E Velez, Stephen Wong, Ram Mani Low-dose lacosamide-induced atrial fibrillation Case analysis with literature review Lacosamide (LCM) is a novel antiepileptic drug (AED) approved by the FDA for adjunctive treatment of partial epilepsy with and without secondary generalization. Lacosamide dose-dependent dysrhythmias (PR-interval prolongation, AV block, and atrial fibrillation/flutter) have been reported. This case ... 2/18/2015
Terence Verla, Andrew Marky, Harrison Farber, Frank W Petraglia, John Gallis, Yuliya Lokhnygina, Beth Parente, Patrick Hickey, Dennis A Turner, Shivanand P Lad Impact of advancing age on post-operative complications of deep brain stimulation surgery for essential tremor Essential tremor (ET) was the original indication for deep brain stimulation (DBS), with USA Food and Drug Administration approval since 1997. Despite the efficacy of DBS, it is associated with surgical complications that cause sub-optimal clinical outcomes. Given that ET is a progressive disease wi... 2/12/2015
Chandra K Flack, M Francesca Monn, Neil B Patel, Thomas A Gardner, Charles R Powell National Trends in the Performance of Robot-Assisted Sacral Colpopexy CONCLUSION: While RASC utilization increased over the study period as a treatment option for vaginal prolapse, the majority of vaginal suspension procedures were still performed via non-RASC methods. RASC was associated with equivalent complications yet significantly higher costs. 2/6/2015
Richard T Addo, Kwame G Yeboah, Rodney C Siwale, Aladin Siddig, Alphia Jones, Ruhi V Ubale, Janet Akande, Henry Nettey, Neil J Patel, Evelyn Addo, Martin J D'Souza Formulation and characterization of atropine sulfate in albumin-chitosan microparticles for in vivo ocular drug delivery The overall study goal was to produce a microparticle formulation containing atropine sulfate for ocular administration with improved efficacy and lower side effects, compared with that of the standard marketed atropine solution. The objective was to prepare an atropine sulfate-loaded bovine serum a... 2/6/2015
Kasey L Jackson, Robert D Dayton, Jeanne M Fisher-Perkins, Peter J Didier, Kate C Baker, Maria Weimer, Amparo Gutierrez, Cooper D Cain, J Michael Mathis, Michael A Gitcho, Bruce A Bunnell, Ronald L Klein Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates CONCLUSIONS: These data indicate that a higher gene vector dose will likely be necessary for more robust effects, yet augur that a relevant primate model is feasible. 2/3/2015
Fang Liu, Min Min Lu, Neil N Patel, Kurt J Schillinger, Tao Wang, Vickas V Patel GATA-Binding Factor 6 Contributes to Atrioventricular Node Development and Function CONCLUSIONS: GATA6 contributes to the development and postnatal function of the murine atrioventricular node by promoting cell-cycle exit of specified cardiomyocytes toward a conduction system lineage. 1/24/2015
Keshab R Parajuli, Qiuyang Zhang, Sen Liu, Neil K Patel, Hua Lu, Shelya X Zeng, Guangdi Wang, Changde Zhang, Zongbing You Methoxyacetic acid suppresses prostate cancer cell growth by inducing growth arrest and apoptosis Methoxyacetic acid (MAA) is a primary metabolite of ester phthalates that are used in production of consumer products and pharmaceutical products. MAA causes embryo malformation and spermatocyte death through inhibition of histone deacetylases (HDACs). Little is known about MAA's effects on cancer c... 1/22/2015
Edward C Mader, Wael Richeh, Joaquin Maury Ochoa, Lacey L Sullivan, Amparo N Gutierrez, Jesus F Lovera Tumefactive multiple sclerosis and hepatitis C virus 2a2C infection Dual benefit of long-term interferon beta-1a therapy Hepatitis C virus (HCV) infection has been implicated in triggering acute disseminated encephalomyelitis but not tumefactive multiple sclerosis. We report the case of a 17-year-old female who presented with a 5-day history of left hemiparesis and hemisensory loss followed by a right third nerve pals... 1/11/2015
Vikas Singh, Nileshkumar J Patel, Apurva O Badheka, Shilpkumar Arora, Nilay Patel, Conrad Macon, Ghanshyambhai T Savani, Sohilkumar Manvar, Jay Patel, Badal Thakkar, Vinaykumar Panchal, Shantanu Solanki, Neil Patel, Ankit Chothani, Sidakpal S Panaich, Vinny Ram, Chad A Kliger, Theodore Schreiber, William O' Neill, Mauricio G Cohen, Carlos E Alfonso, Cindy L Grines, Abeel Mangi, Steven Pfau, John K Forrest, Michael Cleman, Raj Makkar Comparison of outcomes of balloon aortic valvuloplasty plus percutaneous coronary intervention versus percutaneous aortic balloon valvuloplasty alone during the same hospitalization in the United States The use of percutaneous aortic balloon balvotomy (PABV) in high surgical risk patients has resurged because of development of less invasive endovascular therapies. We compared outcomes of concomitant PABV and percutaneous coronary intervention (PCI) with PABV alone during same hospitalization using ... 12/29/2014
Benjamin J Ditty, Nidal B Omar, Paul M Foreman, Daxa M Patel, Patrick R Pritchard, Mamerhi O Okor The nonsurgical nature of patients with subarachnoid or intraparenchymal hemorrhage associated with mild traumatic brain injury CONCLUSIONS: Patients with the constellation of SAH and/or IPH and mTBI do not require neurosurgical consultation, and these findings should not be used as the sole criteria to justify transfer to tertiary referral centers. 12/20/2014
Neil Patel, Florian Moenkemeyer, Susie Germano, Michael M H Cheung Plasma vascular endothelial growth factor A and placental growth factor novel biomarkers of pulmonary hypertension in congenital diaphragmatic hernia Pulmonary hypertension (PH) due to abnormal pulmonary vascular development is an important determinant of illness severity in congenital diaphragmatic hernia (CDH). Vascular endothelial growth factor A (VEGFA) and placental growth factor (PLGF) may be important mediators of pulmonary vascular develo... 12/7/2014
Milliette Alvarado, Margarita Ramirez-Vick, Liurka Lopez, Maria J Marcos-Martinez, Fanor M Saavedra, Juan C Negron-Rivera, Marielba Agosto, Meliza Martinez, Rafael Gonzalez, Myriam Allende-Vigo An uncommon presentation of follicular thyroid carcinoma when chronic back pain should raise a flag Follicular thyroid carcinoma is the second most common type of thyroid cancer, and its incidence has increased dramatically in recent years. Although it typically presents as a thyroid nodule, it can spread to distant sites via hematogenous dissemination. Bone metastasis is diagnosed clinically in 2... 12/5/2014
Paul M Foreman, Philipp Hendrix, Christoph J Griessenauer, Philip G R Schmalz, Mark R Harrigan External ventricular drain placement in the intensive care unit versus operating room evaluation of complications and accuracy CONCLUSION: Patients who underwent ventriculostomy placement in the ICU differed in important ways (i.e. indication for placement and the administration of pre-procedure prophylactic antibiotics) from patients treated in the OR. However, the available data suggests that complications of hemorrhage, ... 12/2/2014
Ariel Furst, Michael G Hill, Jacqueline K Barton Electrocatalysis in DNA Sensors Electrocatalysis is often thought of solely in the inorganic realm, most often applied to energy conversion in fuel cells. However, the ever-growing field of bioelectrocatalysis has made great strides in advancing technology for both biofuel cells as well as biological detection platforms. Within th... 12/2/2014
Jo C Dumville, Paul Coulthard, Helen V Worthington, Philip Riley, Neil Patel, James Darcey, Marco Esposito, Maarten van der Elst, Oscar J F van Waes Tissue adhesives for closure of surgical incisions BACKGROUND: Sutures (stitches), staples and adhesive tapes have been used for many years as methods of wound closure, but tissue adhesives have entered clinical practice more recently. Closure of wounds with sutures enables the closure to be meticulous, but the sutures may show tissue reactivity and... 11/29/2014
Joel R Martin, Owoicho Adogwa, Christopher R Brown, Maragatha Kuchibhatla, Carlos A Bagley, Shivanand P Lad, Oren N Gottfried Experience with intrawound vancomycin powder for posterior cervical fusion surgery CONCLUSIONS: Within the context of an ongoing debate on the effectiveness of locally administered vancomycin powder, the authors found no significant difference in the incidence of deep wound infection rates after posterior cervical fusion surgery with routine use of locally applied vancomycin powde... 11/8/2014
Ariel L Furst, Natalie B Muren, Michael G Hill, Jacqueline K Barton Label-free electrochemical detection of human methyltransferase from tumors The role of abnormal DNA methyltransferase activity in the development and progression of cancer is an essential and rapidly growing area of research, both for improved diagnosis and treatment. However, current technologies for the assessment of methyltransferase activity, particularly from crude tu... 10/8/2014
Xinxia Zhao, Quannetta T Edwards, Neil Patel, Rodney W Hicks Hepatitis B knowledge and preventive practices of Chinese American immigrants in Southern California CONCLUSIONS: Most participants were knowledgeable of HBV (91.6%) or HBV vaccination (70.5%), yet screening and vaccination for the virus were low (36.9% and 26.3%, respectively). Low knowledge was also found regarding modes of disease transmission. Barriers to engage preventive practices included: "... 10/7/2014
Terence Verla, Owoicho Adogwa, Parastou Fatemi, Joel R Martin, Oren N Gottfried, Joseph Cheng, Robert E Isaacs Clinical implication of complications on patient perceived health status following spinal fusion surgery Approximately 2% to 16% of patients undergoing spinal surgery suffer adverse events or complications. There is a paucity of studies evaluating the impact of complications on long-term outcomes. The purpose of this study was to assess the long-term effects of surgical complications on patient functio... 9/29/2014
Michael H Johnson, Roshan T Melvani, Neil N Patel, Christine J Cheng, Richard L Hutchison Radiographic indicators of a shared epiphysis in radial polydactyly CONCLUSION: Radiographic differences exist between children with separate and shared epiphyses. In patients with shared epiphyses, the radial thumb tends to be smaller, closer to the ulnar thumb, and less divergent. Threshold values were identified for predicting the status of the epiphysis based on... 9/6/2014
Neil Patel, Edmund Bailey, Ayeh Mahdmina, Alastair Lomax, Paul Coulthard Domestic violence education for UK and Ireland undergraduate dental students a five-year perspective The purpose of this cross-sectional study was to ascertain whether undergraduate dental students in the United Kingdom and Ireland are receiving formal teaching on recognizing and managing domestic violence (DV) as part of their curricula. A questionnaire was sent to all dental schools in the UK and... 8/3/2014
Paul M Foreman, Philip G R Schmalz, Christoph J Griessenauer Chemoprophylaxis for venous thromboembolism in traumatic brain injury a review and evidence-based protocol Venous thromboembolism (VTE) is a recognized source of morbidity and mortality in patients suffering traumatic brain injury (TBI). While traumatic brain injury is a recognized risk factor for the development of VTE, its presence complicates the decision to begin anticoagulation due to fear of exacer... 7/12/2014
James Paget, Neil Patel, Jacob Manushakian Ulnar nerve compression in Guyons canal MRI does not always have the answer Lipoma is a rare cause of ulnar nerve compression in Guyon's canal. All four previously reported cases from 2000 to 2009 have been accurately diagnosed on MRI. We present a case report where the MRI and surgical findings differed and a summary of the previous cases in the literature. We conclude tha... 6/26/2014
Jay A Vachhani, William C Lee, Jeffrey R Desanto, Andrew J Tsung Magnetic resonance spectroscopy imaging characteristics of cerebral Blastomycosis CONCLUSION: We present the second documented case of intracranial Blastomycosis with MRS imaging. There appears to be a characteristic peak between 3.6 and 3.8 ppm that is thought to represent a "trehalose" peak. This peak is rather specific to fungi and can be helpful in differentiating fungal absc... 6/21/2014
Paul M Foreman, James M Markert, Arnold G Diethelm, Mark N Hadley The history of neurosurgery at the University of Alabama at Birmingham : The Division of Neurosurgery at the University of Alabama at Birmingham was formally founded in 1954 under the leadership of James Garber Galbraith. The following 60 years would see neurosurgery at the forefront of the development of a nationally recognized medical center in the heart of Birmingha... 6/17/2014
Owoicho Adogwa, Kevin Carr, Parastou Fatemi, Terence Verla, Gustavo Gazcon, Oren Gottfried, Carlos Bagley, Joseph Cheng Psychosocial factors and surgical outcomes are elderly depressed patients less satisfied with surgery CONCLUSION: This study demonstrates that independent of surgical effectiveness, baseline depression influence patient satisfaction with health care, 2 years after revision lumbar surgery. Quality improvement initiatives using patient satisfaction as a proxy for quality of care should account for pat... 6/13/2014
Neil Patel, Richard T Addo, Ruhi Ubale, Mohammed Nasir Uddin, Martin D'Souza, Lynetta Jobe The effect of antisense to NF-B in an albumin microsphere formulation on the progression of left-ventricular remodeling associated with chronic volume overload in rats CONCLUSION: This treatment was successful in curbing ventricular remodeling by suppressing NF-κB activation. 6/4/2014
Owoicho Adogwa, Joel R Martin, Kevin Huang, Terence Verla, Parastou Fatemi, Paul Thompson, Joseph Cheng, Maragatha Kuchibhatla, Shivanand P Lad, Carlos A Bagley, Oren N Gottfried Preoperative serum albumin level as a predictor of postoperative complication after spine fusion CONCLUSION: Preoperative hypoalbuminemia is an independent risk factor for postoperative complications after elective spine surgery for degenerative and deformity causes, and should be used more frequently as a prognostic tool to detect malnutrition and risk of adverse surgical outcomes. 5/31/2014
Matthew J Grosso, Virgilio Matheus, Megan Clark, Nico van Rooijen, Christopher A Iannotti, Michael P Steinmetz Effects of an immunomodulatory therapy and chondroitinase after spinal cord hemisection injury CONCLUSION: The present data suggest that delivery of an immunomodulatory therapy consisting of clodronate and rolipram, in combination with ChABC, reduces axonal injury and enhances neuroprotection, plasticity, and hindlimb functional recovery after hemisection spinal cord injury in adult rats. 5/30/2014
Owoicho Adogwa, Terence Verla, Paul Thompson, Anirudh Penumaka, Katherine Kudyba, Kwame Johnson, Erin Fulchiero, Timothy Miller, Kimberly B Hoang, Joseph Cheng, Carlos A Bagley Affective disorders influence clinical outcomes after revision lumbar surgery in elderly patients with symptomatic adjacent-segment disease, recurrent stenosis, or pseudarthrosis clinical article CONCLUSIONS: The extent of preoperative depression is an independent predictor of less functional improvement following revision lumbar surgery in elderly patients with symptomatic ASD, pseudarthrosis, or recurrent stenosis. Timely diagnosis and treatment of depression and somatic anxiety in this co... 5/20/2014
Paul Coulthard, Evgeny Kushnerev, Julian M Yates, Tanya Walsh, Neil Patel, Edmund Bailey, Tara F Renton Interventions for iatrogenic inferior alveolar and lingual nerve injury BACKGROUND: Iatrogenic injury of the inferior alveolar or lingual nerve or both is a known complication of oral and maxillofacial surgery procedures. Injury to these two branches of the mandibular division of the trigeminal nerve may result in altered sensation associated with the ipsilateral lower ... 4/18/2014
Paul M Foreman, Christoph J Griessenauer, Michael Falola, Mark R Harrigan Extracranial traumatic aneurysms due to blunt cerebrovascular injury CONCLUSIONS: The majority of traumatic aneurysms can be managed with an antiplatelet regimen of 325 mg aspirin daily and serial imaging. Saccular aneurysms have a greater tendency to enlarge when compared with fusiform aneurysms. 4/8/2014
Neil D Patel, Kiran K Mallulla, Ra-id Abdulla Atrial flutter demonstrated by M-mode echocardiography This report and images describe a case of atrial flutter with 2:1 conduction pattern in a 3 year-old male with d-TGA, ASD, and VSD status-post repair, which was demonstrated by M-mode echocardiography. 3/25/2014
Christoph J Griessenauer, Joseph H Miller, Bonita S Agee, Winfield S Fisher, Joel K Curé, Philip R Chapman, Paul M Foreman, Wilson A M Fisher, Adam C Witcher, Beverly C Walters Observer reliability of arteriovenous malformations grading scales using current imaging modalities CONCLUSION: The 5-tier Spetzler-Martin scale, the 3-tier Spetzler-Ponce scale, and the Pollock-Flickinger radiosurgery-based scale all showed a high level of agreement. The improved reliability on reassessment was explained by a training effect from the initial assessment and the requirement to defe... 3/18/2014
Neelam Gupta, C Omar Kamlin, Michael Cheung, Michael Stewart, Neil Patel Improving diagnostic accuracy in the transport of infants with suspected duct-dependent congenital heart disease CONCLUSIONS: Clinical diagnosis of DDCHD outside of a cardiac centre is challenging. No single factor predicts DDCHD. Combined interpretation of clinical, physiological and x-ray findings may assist. 1/9/2014
Luke A Wilhelm, Joel R Martin, Mark L Latash, Vladimir M Zatsiorsky Finger enslaving in the dominant and non-dominant hand During single-finger force production, the non-instructed fingers unintentionally produce force (finger enslaving). In this study, enslaving effects were compared between the dominant and non-dominant hands. The test consisted of a series of maximum voluntary contractions with different finger combi... 12/24/2013
Ariel L Furst, Michael G Hill, Jacqueline K Barton DNA-modified electrodes fabricated using copper-free click chemistry for enhanced protein detection A method of DNA monolayer formation has been developed using copper-free click chemistry that yields enhanced surface homogeneity and enables variation in the amount of DNA assembled; extremely low-density DNA monolayers, with as little as 5% of the monolayer being DNA, have been formed. These DNA-m... 12/17/2013
Ariel Furst, Sally Landefeld, Michael G Hill, Jacqueline K Barton Electrochemical patterning and detection of DNA arrays on a two-electrode platform We report a novel method of DNA array formation that is electrochemically formed and addressed with a two-electrode platform. Electrochemical activation of a copper catalyst, patterned with one electrode, enables precise placement of multiple sequences of DNA onto a second electrode surface. The two... 12/17/2013
Neelam Gupta, Louise Leven, Michael Stewart, Michael Cheung, Neil Patel Transport of infants with congenital heart disease benefits of antenatal diagnosis CONCLUSIONS: Improved antenatal detection would allow for safer, less resource intense transfers of infants with CHD. 12/12/2013
Amparo Gutierrez, John D England Administration of glucocorticoids in boys with Duchenne muscular dystrophy Duchenne muscular dystrophy (DMD) is the most common neuromuscular disease affecting boys. Advances in their care can delay the progression of DMD-related disability and prolong survival. The administration of glucocorticoids is among these advances. Glucocorticoid therapy, however, is associated wi... 12/6/2013
Alexander G Bien, Marshall C Cress, Susan B Nguyen, Steven J Westgate, Ashish Nanda Endovascular treatment of a temporal bone pseudoaneurysm presenting as bloody otorrhea Objective This case report is designed to illustrate an uncommon presentation of osteoradionecrosis (ORN) of the temporal bone and a treatment method for bloody otorrhea from a pseudoaneurysm of the internal carotid artery (ICA). Design This is a single patient case report Setting University of Miss... 12/3/2013
Shariq A Khan, David L McDonagh, Owoicho Adogwa, Sankalp Gokhale, Ulysses N Toche, Terence Verla, Ali R Zomorodi, Gavin W Britz Perioperative cardiac complications and 30-day mortality in patients undergoing intracranial aneurysmal surgery with adenosine-induced flow arrest a retrospective comparative study CONCLUSION: Our results suggest that adenosine-assisted intracranial aneurysm surgery is not associated with an increase in perioperative cardiac complications or mortality in patients with low risk of coronary artery disease and may be considered a safe technique to assist clipping of complex aneur... 11/27/2013
Neil Patel, Michael West, Joanie Wurster, Cassie Tillman Pediatric traumatic brain injuries treated with decompressive craniectomy CONCLUSION: This study supports the current literature that decompressive craniectomy is no longer an intervention used as a last resort but an effective first line treatment to be considered. 11/16/2013
Anja Bialkowski, Florian Moenkemeyer, Neil Patel Intravenous sildenafil in the management of pulmonary hypertension associated with congenital diaphragmatic hernia CONCLUSIONS: IV sildenafil infusion was associated with improved oxygenation. Prospective trials of IV sildenafil are required to determine effects on longer term outcome. 10/29/2013
Joel R Martin, Owoicho Adogwa, Christopher R Brown, Carlos A Bagley, William J Richardson, Shivanand P Lad, Maragatha Kuchibhatla, Oren N Gottfried Experience with intrawound vancomycin powder for spinal deformity surgery CONCLUSION: The local application of powdered vancomycin was not associated with a significant difference in the rate of deep SSI after spinal deformity surgery, and other treatment modalities are necessary to limit infection for this high-risk group. This study is in contrary to prior studies, whic... 10/26/2013
Angela N Spurgeon, Marshall C Cress, Oroszi Gabor, Qing-Qing Ding, Tomoko Tanaka, Douglas C Miller Oncogenic brain metazoan parasite infection Multiple observations suggest that certain parasitic infections can be oncogenic. Among these, neurocysticercosis is associated with increased risk for gliomas and hematologic malignancies. We report the case of a 71-year-old woman with colocalization of a metazoan parasite, possibly cysticercosis, ... 10/24/2013
Ankit I Mehta, Owoicho Adogwa, Isaac O Karikari, Paul Thompson, Terence Verla, Ulysses T Null, Allan H Friedman, Joseph S Cheng, Carlos A Bagley, Robert E Isaacs Anatomical location dictating major surgical complications for intradural extramedullary spinal tumors a 10-year single-institutional experience CONCLUSIONS: Spinal IDEM tumors that are anteriorly located in the upper thoracic spine were found to have the highest rate of surgery-related complications and postoperative neurological deficits. This finding may be associated with the unforgiving anatomy of the upper thoracic spine in which there... 10/15/2013
Neil D Patel, Damien Kenny, Ismael Gonzalez, Zahid Amin, Michel N Ilbawi, Ziyad M Hijazi Single-center outcome analysis comparing reintervention rates of surgical arterioplasty with stenting for branch pulmonary artery stenosis in a pediatric population Although catheter-based intervention is generally accepted as the treatment of choice for branch pulmonary artery (PA) stenosis, there are no data directly comparing both the need for reintervention and time to reintervention in patients undergoing transcatheter stenting versus surgical arterioplast... 10/8/2013
Edward C Diaz, Samer Susan, Neil S Patel, Byron H Lee, Mark Cabelin, Monish Aron, Robert J Stein Laparoscopic-assisted vesicocalicostomy for severe pelvi-ureteral stricture disease A 39-year-old female previously treated with shock wave lithotripsy developed extensive ureteral stricture disease. After 2 unsuccessful attempts at retrograde balloon dilatation, she was evaluated at our center for further management. Successful reconstruction was performed with laparoscopic-assist... 9/11/2013
Katharine D Hagen, James M Gillan, Sang-Choul Im, Sally Landefeld, Griffin Mead, Megan Hiley, Lucy A Waskell, Michael G Hill, Andrew K Udit Electrochemistry of mammalian cytochrome P450 2B4 indicates tunable thermodynamic parameters in surfactant films Electrochemical methods continue to present an attractive means for achieving in vitro biocatalysis with cytochromes P450; however understanding fully the nature of electrode-bound P450 remains elusive. Herein we report thermodynamic parameters using electrochemical analysis of full-length mammalian... 9/10/2013
Amparo Gutierrez, John D England How to explore a patient with a chronic axonal polyneuropathy Chronic axonal polyneuropathies are very frequently encountered by physicians. It is important to take a systematic approach when evaluating these patients. In this chapter we present such an approach. We present the diagnostic recommendations based on previously published evidence-based reviews and... 8/13/2013
Florian Moenkemeyer, Neil Patel Right ventricular diastolic function measured by tissue Doppler imaging predicts early outcome in congenital diaphragmatic hernia CONCLUSIONS: Tissue Doppler imaging mean right ventricular early diastolic myocardial velocity on days 1 and 2 of life predicted early outcome in surviving infants with congenital diaphragmatic hernia. Right ventricular diastolic dysfunction is associated with disease severity in congenital diaphrag... 8/9/2013
Shariq A Khan, Owoicho Adogwa, Tong J Gan, Ulysses T Null, Terence Verla, Sankalp Gokhale, William D White, Gavin W Britz, Ali R Zomorodi, Michael L James, David L McDonagh Effect of 6 hydroxyethyl starch 13004 in 09 sodium chloride Voluven on complications after subarachnoid hemorrhage a retrospective analysis CONCLUSION: We observed increased complications after SAH with 6% HES 130/0.4 (Voluven®) administration. An adequately powered prospective randomized controlled trial into the safety of 6% HES 130/0.4 in this patient population is warranted. 7/27/2013
Joanna Behrsin, Michael Cheung, Neil Patel Sildenafil weaning after discharge in infants with congenital diaphragmatic hernia Sildenafil is used to treat pulmonary hypertension (PAH) in infants with congenital diaphragmatic hernia (CDH). However, data to guide sildenafil dosing and weaning are limited. This is concerning in light of a recent report describing increased risk associated with high-dose sildenafil regimens in ... 7/24/2013
Jennifer M Mason, Ishita Das, Martin Arlt, Neil Patel, Stephanie Kraftson, Thomas W Glover, JoAnn M Sekiguchi The SNM1BAPOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability SNM1B/Apollo is a DNA nuclease that has important functions in telomere maintenance and repair of DNA interstrand crosslinks (ICLs) within the Fanconi anemia (FA) pathway. SNM1B is required for efficient localization of key repair proteins, such as the FA protein, FANCD2, to sites of ICL damage and ... 7/19/2013
Jeffrey J Warren, Nadia Herrera, Michael G Hill, Jay R Winkler, Harry B Gray Electron flow through nitrotyrosinate in Pseudomonas aeruginosa azurin We have designed ruthenium-modified Pseudomonas aeruginosa azurins that incorporate 3-nitrotyrosine (NO2YOH) between Ru(2,2'-bipyridine)2(imidazole)(histidine) and Cu redox centers in electron transfer (ET) pathways. We investigated the structures and reactivities of three different systems: RuH107N... 7/18/2013
Kiran K Mallula, Neil D Patel, Ziyad M Hijazi, Swosti Joshi, Zahra Naheed Double-outlet right ventricle with an intact ventricular septum a unique stage 1 palliation This report describes a case of double-outlet right ventricle with intact ventricular septum diagnosed in a newborn male. The initial diagnosis was made by echocardiography. The baby underwent a hybrid procedure including pulmonary artery banding and stenting of the patent ductus arteriosus. He subs... 7/12/2013
Marcia J Hay-McCutcheon, Nathaniel R Peterson, Christian A Rosado, David B Pisoni Identification of acoustically similar and dissimilar vowels in profoundly deaf adults who use hearing aids andor cochlear implants some preliminary findings CONCLUSIONS: Identification performance was affected by the acoustic similarity of the vowels. Older adults experienced more difficulty identifying acoustically similar confusable vowels than did younger adults. The findings might lend support to the ease of language understanding model (Ronnberg, R... 7/5/2013
Michael J Walden, Mehmet E Adin, Ravindran Visagan, Valentina G Viertel, Jarunee Intrapiromkul, Fernando Maluf, Neil V Patel, Fatma Alluwaimi, Doris Lin, David M Yousem Cervical ribs identification on MRI and clinical relevance To determine the prevalence of cervical ribs on cervical spine MRI and clinical relevance, we reviewed 2500 studies for cervical ribs and compression of neurovascular structures and compared to CT, when available. Brachial plexus or subclavian artery contact by cervical rib was identified on MRI and... 6/14/2013
Mary E J Lott, Julia E Slocomb, Vikram Shivkumar, Bruce Smith, David Quillen, Robert A Gabbay, Thomas W Gardner, Kerstin Bettermann Impaired retinal vasodilator responses in prediabetes and type 2 diabetes CONCLUSION: Retinal reactivity was impaired in prediabetic and type 2 diabetic individuals in parallel with reduced insulin sensitivity but not associated with levels of hs-CRP. Retinal vasoreactivity measurements may be a sensitive tool to assess early vascular risk. 6/8/2013
Joel R Martin, Alexander V Terekhov, Mark L Latash, Vladimir M Zatsiorsky Optimization and variability of motor behavior in multifinger tasks what variables does the brain use The neural control of movement has been described using different sets of elemental variables. Two possible sets of elemental variables have been suggested for finger pressing tasks: the forces of individual fingers and the finger commands (also called finger modes or central commands). The authors ... 6/8/2013
Fernando L Vale, Stephen Reintjes, Hermes G Garcia Complications after mesial temporal lobe surgery via inferiortemporal gyrus approach CONCLUSIONS: The inferior temporal gyrus approach to mesial temporal lobe resection is a safe and effective method for treating temporal lobe epilepsy. Morbidity and mortality rates associated with this procedure are lower than those associated with other neurosurgical procedures. The finding that s... 6/4/2013
Rafal Goraczniak, Brian A Wall, Mark A Behlke, Kim A Lennox, Eric S Ho, Nikolas H Zaphiros, Christopher Jakubowski, Neil R Patel, Steven Zhao, Carlo Magaway, Stacey A Subbie, Lumeng Jenny Yu, Stephanie Lacava, Kenneth R Reuhl, Suzie Chen, Samuel I Gunderson U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo U1 Adaptor is a recently discovered oligonucleotide-based gene-silencing technology with a unique mechanism of action that targets nuclear pre-mRNA processing. U1 Adaptors have two distinct functional domains, both of which must be present on the same oligonucleotide to exert their gene-silencing fu... 5/16/2013
Mohammad Nasir Uddin, Neil J Patel, Tuhin Bhowmik, Bernadette D'Souza, Archana Akalkotkar, Frank Etzlar, Carl William Oettinger, Martin D'Souza Enhanced bioavailability of orally administered antisense oligonucleotide to nuclear factor kappa B mRNA after microencapsulation with albumin Antisense molecules that pertain to ribonucleic acid (RNA) and complementary to the messenger RNA (mRNA) are produced by transcription of a given gene. Antisense oligonucleotides have emerged as potential gene-specific therapeutic agents that are currently undergoing evaluation in clinical trials fo... 3/14/2013
Jeffrey P Blount, Amber S Gordon, Paul M Foreman, John H Grant Multidisciplinary staged surgical management of bifrontal meningoencephalocele with long-term follow-up The authors report on an infant with a bifrontal encephalocele that was associated with multisuture craniosynostosis, spasticity, and a progressively severe epilepsy. They describe the initial presentation, genetic screening results, staged multidisciplinary operative plans, clinical course, complic... 1/29/2013
Jay A Vachhani, Jeffrey D Klopfenstein Incidence of neurosurgical wrong-site surgery before and after implementation of the universal protocol CONCLUSION: A statistically significant reduction in overall WSS was seen after implementation of the UP. This reduction can be attributed to less frequent wrong-level spine surgery. There was no case of wrong procedure or patient surgery and the 1 case of wrong-side surgery occurred after UP implem... 12/25/2012
Joel R Martin, Florent Paclet, Mark L Latash, Vladimir M Zatsiorsky Changes in the flexor digitorum profundus tendon geometry in the carpal tunnel due to force production and posture of metacarpophalangeal joint of the index finger an MRI study BACKGROUND: Carpal tunnel syndrome is a disorder caused by increased pressure in the carpal tunnel associated with repetitive, stereotypical finger actions. Little is known about in vivo geometrical changes in the carpal tunnel caused by motion at the finger joints and exerting a fingertip force. 12/11/2012
Joel R Martin, Alexander V Terekhov, Mark L Latash, Vladimir M Zatsiorsky Comparison of interfinger connection matrix computation techniques A hypothesis was proposed that the central nervous system controls force production by the fingers through hypothetical neural commands. The neural commands are scaled between values of 0 to 1, indicating no intentional force production or maximal voluntary contraction (MVC) force production, respec... 11/28/2012
Karun Dewan, Viren Vithlani, Neil Patel, Kathy Warren A study to assess management of patients on warfarin by general dental practitioners GDPs in the West Midlands Current management protocols for anticoagulated patients undergoing dental procedures are influenced by evidence-based guidelines. These guidelines state that the risk of significant bleeding is low in patients who have a stable INR within a therapeutic range, (2-4). The risks of interruption of ant... 11/22/2012
Jiri Brabec, Shuchi Chaudhary, Yu-Tze Ng Ictal priapism as an autonomic manifestation of Panayiotopoulos syndrome Panayiotopoulos syndrome is an idiopathic epilepsy syndrome presenting with a large variety of autonomic symptoms. The mechanism of autonomic symptoms is still not well understood. A neurologically normal 13-month-old boy presented on 2 occasions with complex partial status epilepticus that included... 11/1/2012
Jay A Vachhani, Daniel R Fassett Intramedullary neurenteric cyst associated with a tethered spinal cord Case report and literature review CONCLUSION: A search of the literature since the advent of MRI showed 29 published cases of intramedullary neurentic cysts. Of the 24 published cases with a follow-up MRI, the average recurrence rate was 25% with a mean follow up of 51 months. 9/1/2012
Marshall C Cress, Angela N Spurgeon, Douglas C Miller, N Scott Litofsky Cerebral edema associated with ventricular reservoirs in two patients a case report Placement of ventricular reservoirs is a common practice to treat various tumors of the central nervous system (CNS). Ventricular catheter-reservoir-associated edema has been noted in the literature, but a thorough review of this literature identified no articles that examine this particular complic... 9/1/2012
Edward C Diaz, Samer Susan, Neil S Patel, Byron H Lee, Mark Cabelin, Monish Aron, Robert J Stein Laparoscopic-assisted vesicocalicostomy for severe pelvi-ureteral stricture disease A 39-year-old female previously treated with shock wave lithotripsy developed extensive ureteral stricture disease. After 2 unsuccessful attempts at retrograde balloon dilatation, she was evaluated at our center for further management. Successful reconstruction was performed with laparoscopic-assist... 8/22/2012
Haitao Wu, Yisheng Lu, Chengyong Shen, Neil Patel, Lin Gan, Wen C Xiong, Lin Mei Distinct roles of muscle and motoneuron LRP4 in neuromuscular junction formation Neuromuscular junction (NMJ) formation requires precise interaction between motoneurons and muscle fibers. LRP4 is a receptor of agrin that is thought to act in cis to stimulate MuSK in muscle fibers for postsynaptic differentiation. Here we dissected the roles of LRP4 in muscle fibers and motoneuro... 7/17/2012
Akram Shhadeh, Ankur Garg, Ameer E Hassan, Steven Hoover, Scott Saucedo, Baharra Hassansad, Oriana Cornett, Vahid Tohidi, Adnan I Qureshi, Jawad F Kirmani Recanalization following various endovascular modalities for treatment of anterior circulation acute ischemic strokes Currently several endovascular modalities and devices are available for use in acute ischemic stroke setting. Limited data exist regarding the relative efficacy of these different options when used individually or in combination. The primary objective of this study was to retrospectively compare the... 6/28/2012
Maneesh G Kumar, Neil M Patel, Adam M Nicholson, Amanda L Kalen, Ehab H Sarsour, Prabhat C Goswami Reactive oxygen species mediate microRNA-302 regulation of AT-rich interacting domain 4a and C-C motif ligand 5 expression during transitions between quiescence and proliferation Normal cell growth consists of two distinct phases, quiescence and proliferation. Quiescence, or G(0), is a reversible growth arrest in which cells retain the ability to reenter the proliferative cycle (G(1), S, G(2), and M). Although not actively dividing, quiescent cells are metabolically active a... 6/27/2012
Neil Patel Use of milrinone to treat cardiac dysfunction in infants with pulmonary hypertension secondary to congenital diaphragmatic hernia a review of six patients CONCLUSIONS: Milrinone use was associated with an improvement in systolic and diastolic function in the RV, corresponding to an improvement in clinical status. 6/20/2012
Kerstin Bettermann, Julia E Slocomb, Vikram Shivkumar, Mary E J Lott Retinal vasoreactivity as a marker for chronic ischemic white matter disease CONCLUSION: In this study functional and structural impairment of the retinal microvasculature were associated with ischemic WMD and measures of cerebral vascular function. Microvascular dysfunction in the eye may predict cerebral small vessel disease, but validation by larger studies is needed. 6/13/2012
Mary E J Lott, Julia E Slocomb, Vikram Shivkumar, Bruce Smith, Robert A Gabbay, David Quillen, Thomas W Gardner, Kerstin Bettermann Comparison of retinal vasodilator and constrictor responses in type 2 diabetes CONCLUSION: This suggests that both responses are attenuated to a similar degree in diabetic subjects and that the attenuation to both stimuli can be observed in retinal arteries and veins. This would suggest that similar vasoregulatory factor(s) might in part help to explain the retinal diameter re... 6/12/2012
Bryan M Hunter, Randy M Villahermosa, Christopher L Exstrom, Michael G Hill, Kent R Mann, Harry B Gray M-M bond-stretching energy landscapes for M2dimen42 M Rh, Ir; dimen 1,8-diisocyanomenthane complexes Isomers of Ir(2)(dimen)(4)(2+) (dimen = 1,8-diisocyanomenthane) exhibit different Ir-Ir bond distances in a 2:1 MTHF/EtCN solution (MTHF = 2-methyltetrahydrofuran). Variable-temperature absorption data suggest that the isomer with the shorter Ir-Ir distance is favored at room temperature [K = ∼8; ΔH... 5/25/2012
Rodolfo E Camacho-Aguilera, Yan Cai, Neil Patel, Jonathan T Bessette, Marco Romagnoli, Lionel C Kimerling, Jurgen Michel An electrically pumped germanium laser Electrically pumped lasing from Germanium-on-Silicon pnn heterojunction diode structures is demonstrated. Room temperature multimode laser with 1mW output power is measured. Phosphorous doping in Germanium at a concentration over 4x10^(19)cm^(-3) is achieved. A Germanium gain spectrum of nearly 200n... 5/9/2012
Tarique Zaman, Shikhar Agarwal, Abdel G Anabtawi, Neil S Patel, Stephen G Ellis, E Murat Tuzcu, Samir R Kapadia Angiographic lesion severity and subsequent myocardial infarction We sought to determine the angiographic severity of coronary lesions leading to ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) with a focus on determining the impact of interval from initial angiogram to subsequent clinical event. In the late 1980s angiographic data on les... 4/14/2012
Neil S Patel, Gosta Pettersson, E Murat Tuzcu, Samir R Kapadia Successful surgical repair of iatrogenic pulmonary vein stenosis Pulmonary vein stenosis can complicate ablation procedures for atrial fibrillation and often presents with severe respiratory symptoms. Described in this case report is a 21-year-old male who underwent a bilateral surgical augmentation of the pulmonary veins for severe occlusive pulmonary vein steno... 3/21/2012
Pao T Lin, Michiel Vanhoutte, Neil S Patel, Vivek Singh, Juejun Hu, Yan Cai, Rodolfo Camacho-Aguilera, Jurgen Michel, Lionel C Kimerling, Anu Agarwal Engineering broadband and anisotropic photoluminescence emission from rare earth doped tellurite thin film photonic crystals Broadband and anisotropic light emission from rare-earth doped tellurite thin films is demonstrated using Er3+-TeO2 photonic crystals (PhCs). By adjusting the PhC parameters, photoluminescent light can be efficiently coupled into vertical surface emission or lateral waveguide propagation modes. Beca... 2/15/2012
Dilip R Patel, Cynthia Feucht, Lesley Reid, Neil D Patel Pharmacologic agents for smoking cessation a clinical review Tobacco use has been clearly demonstrated to have negative health consequences. Smoking cigarettes is the predominant method of tobacco use. The tar contained within cigarettes and other similar products is also harmful. Other tarless tobacco containing products do exist but carry no significantly d... 2/1/2012
Sachin S Goel, Shikhar Agarwal, E Murat Tuzcu, Stephen G Ellis, Lars G Svensson, Tarique Zaman, Navkaranbir Bajaj, Lee Joseph, Neil S Patel, Olcay Aksoy, William J Stewart, Brian P Griffin, Samir R Kapadia Percutaneous coronary intervention in patients with severe aortic stenosis implications for transcatheter aortic valve replacement CONCLUSIONS: PCI can be performed in patients with severe symptomatic AS and coronary artery disease without an increased risk of short-term mortality compared with propensity-matched patients without AS. Patients with ejection fraction ≤30% and Society of Thoracic Surgeons score ≥10% are at a highe... 1/28/2012
Fanor M Saavedra, Emil A Pastrana, Lincoln M Jiménez, Milagros Fernández, Jorge Billoch, Ivan Sosa, Juan Vigo Pediatric brain tumors in Puerto Rico CONCLUSION: Our results provide an objective platform for further epidemiological studies and for the development of local health strategies for the timely diagnosis and treatment of the most common pediatric tumors in Puerto Rico. 1/24/2012
Joel R Martin, Mark L Latash, Vladimir M Zatsiorsky Effects of the index finger position and force production on the flexor digitorum superficialis moment arms at the metacarpophalangeal joints - a magnetic resonance imaging study BACKGROUND: The purpose of this study was to use magnetic resonance imaging to measure the moment arm of the flexor digitorum superficialis tendon about the metacarpophalangeal joint of the index, middle, ring, and little fingers when the position and force production level of the index finger was a... 12/24/2011
Emil A Pastrana, Fanor M Saavedra, Gisela Murray, Samuel Estronza, John D Rolston, Gloria Rodriguez-Vega Acute adrenal insufficiency in cervical spinal cord injury CONCLUSIONS: Adrenal insufficiency is a poorly recognized complication in patients with acute cervical spinal cord injury and its aggressive treatment is of utmost importance to avoid further neurological injury. 11/29/2011
Eric D Olmon, Michael G Hill, Jacqueline K Barton Using metal complex reduced states to monitor the oxidation of DNA Metallointercalating photooxidants interact intimately with the base stack of double-stranded DNA and exhibit rich photophysical and electrochemical properties, making them ideal probes for the study of DNA-mediated charge transport (CT). The complexes [Rh(phi)(2)(bpy')](3+) (phi = 9,10-phenanthrene... 11/3/2011
Alexandra Rivera-Vega, Larissa Peguero, Edgar Colon, Fanor M Saavedra, Ivan Sosa, Edwardo Ramos Fibrotendinous band causing neurogenic Thoracic Outlet Syndrome in adolescent with bilateral cervical ribs Thoracic Outlet Syndrome (TOS) describes a variety of symptoms caused by the compression of the neurovascular structures in the cervicoaxillary region as they leave the thorax toward the upper limbs. Causes of TOS are vascular and neurogenic, with neurogenic symptoms being the most common presentati... 9/30/2011
Martin M Mortazavi, Andrew K Romeo, Aman Deep, Christoph J Griessenauer, Mohammadali M Shoja, R Shane Tubbs, Winfield Fisher Hypertonic saline for treating raised intracranial pressure literature review with meta-analysis CONCLUSIONS: The available data are limited by low patient numbers, limited RCTs, and inconsistent methods between studies. However, a greater part of the data suggest that HTS given as either a bolus or continuous infusion can be more effective than mannitol in reducing episodes of elevated ICP. A ... 9/28/2011
Clairisse van der Felt, Kevork Hindoyan, Kang Choi, Nazafarin Javdan, Peter Goldman, Rose Bustos, Andrew G Star, Bryan M Hunter, Michael G Hill, Aram Nersissian, Andrew K Udit Electron-transfer rates govern product distribution in electrochemically-driven P450-catalyzed dioxygen reduction Developing electrode-driven biocatalytic systems utilizing the P450 cytochromes for selective oxidations depends not only on achieving electron transfer (ET) but also doing so at rates that favor native-like turnover. Herein we report studies that correlate rates of heme reduction with ET pathways a... 9/21/2011
Maura H Mulroy, Andre M Loyd, Donald P Frush, Terence G Verla, Barry S Myers, Cameron R Dale Bass Evaluation of pediatric skull fracture imaging techniques Radiologic imaging is crucial in the diagnosis of skull fracture, but there is some doubt as to whether different imaging modalities can accurately identify fractures present on a human skull. While studies have been performed to evaluate the efficacy of radiologic imaging at other anatomical locati... 9/2/2011
Andrew J Woolley, Himanshi A Desai, Mitchell A Steckbeck, Neil K Patel, Kevin J Otto In situ characterization of the brain-microdevice interface using device-capture histology Accurate assessment of brain-implantable microdevice bio-integration remains a formidable challenge. Prevailing histological methods require device extraction prior to tissue processing, often disrupting and removing the tissue of interest which had been surrounding the device. The Device-Capture Hi... 8/2/2011
R Shane Tubbs, Matthew C Blouir, Andrew K Romeo, Martin M Mortazavi, Aaron A Cohen-Gadol Spinal cord ischemia and atherosclerosis a review of the literature CONCLUSIONS: Much of the current literature regarding atherosclerosis and spinal cord ischemia is vague and conflicting. Future studies aimed at, for example, imaging of the spinal cord in patients with ischemic-like symptoms are warranted. 6/29/2011
James Parker, Neil Patel, Ganesh Devarajan Proximal femoral fracture in a man resulting from modern clipless pedals a case report CONCLUSION: This case highlights the dangers of clipless pedals even in experienced cyclists, and underlines the importance of proper information for their correct setup to minimise the risk of potentially serious injuries, especially in the region of the hip. 6/9/2011
Joel R Martin, Mark L Latash, Vladimir M Zatsiorsky Coordination of contact forces during multifinger static prehension This study investigated the effects of modifying contact finger forces in one direction-normal or tangential-on the entire set of the contact forces, while statically holding an object. Subjects grasped a handle instrumented with finger force-moment sensors, maintained it at rest in the air, and the... 5/18/2011
Suet Ching Chen, Gillian Hawkins, Esther Aspinall, Neil Patel Factors influencing uptake of influenza A H1N1 vaccine amongst healthcare workers in a regional pediatric centre lessons for improving vaccination rates CONCLUSIONS: Vaccine uptake may be increased by addressing HCW knowledge and attitudes and access to vaccine. Future vaccination programmes should include targeted education and vaccine delivery, at the convenience of staff, and in their own department. 4/30/2011
Zachary M Hurwitz, Richard Montilla, Raymond M Dunn, Neil V Patel, Mustafa Akyurek Adductor magnus perforator flap revisited an anatomical review and clinical applications CONCLUSION: The adductor magnus perforator flap is a reliable flap that offers robust blood supply, through a consistent vascular pedicle, to an extensive skin territory. Our anatomic studies revealed the consistent presence of 2 proximal perforators in the medial thigh that are linked by an intramu... 4/1/2011
Robert W Hartsock, Wenkai Zhang, Michael G Hill, Bridgett Sabat, Kelly J Gaffney Characterizing the deformational isomers of bimetallic Ir2dimen42 dimen 1,8-diisocyano-p-menthane with vibrational wavepacket dynamics We studied the Ir(2)(dimen)(4)(2+) complex with ultrafast transient absorption spectroscopy and density functional theory and concluded that it possesses two singlet ground state isomers in room temperature solution. The molecule can adopt either a paddle wheel or a propeller conformation in solutio... 3/25/2011
Fatih Altunrende, Riccardo Autorino, Neil S Patel, Michael A White, Rakesh Khanna, Humberto Laydner, Bo Yang, Georges-Pascal Haber, Jihad H Kaouk, Robert J Stein Robotic bladder diverticulectomy technique and surgical outcomes CONCLUSIONS: Robotic surgery represents a reasonable minimally invasive treatment option for resection of bladder diverticula when indicated. 2/9/2011
Robert J Stein, Andre K Berger, Ricardo Brandina, Neil S Patel, David Canes, Brian H Irwin, Monish Aron, Riccardo Autorino, Gaurang Shah, Mihir M Desai Laparoendoscopic single-site pyeloplasty a comparison with the standard laparoscopic technique CONCLUSIONS: • No benefit was noted for LESS pyeloplasty over the standard laparoscopic procedure beyond aesthetic advantages. • Further comparisons are needed to determine whether these results are generalizable to other LESS procedures. 9/1/2010
Ketan B Ghaghada, Rivka R Colen, Catherine R Hawley, Neil Patel, Srinivasan Mukundan Liposomal contrast agents in brain tumor imaging Treatment of glioblastoma multiforme remains a major challenge despite advances in standard therapy, including surgery, radiation, and chemotherapy. The field of nanomedicine is expected to have a major impact on the treatment and management of brain tumors. Over the past decade, significant efforts... 8/17/2010
Erin Duchan, Neil D Patel, Cynthia Feucht Energy drinks a review of use and safety for athletes Energy drinks have increased in popularity in adolescents and young adults; however, concerns have been raised regarding the ingredients in energy drinks and their potential negative effects on health. Caffeine, the most physiologically active ingredient in energy drinks, is generally considered saf... 7/16/2010
N Scott Litofsky, Joshua Matthews, Michael L Wolak, M Mohsin Shah, Itay Melamed, Lori A Thombs Optimizing referral practices for patients with non-traumatic intracerebral hemorrhage Because many cases of non-traumatic intracerebral hemorrhage (NTICH) do not require surgery, establishing the most appropriate referral and treatment algorithms to optimize patient outcome, including appropriate utilization of specialty physicians, such as neurosurgeons and neurologists, would be he... 7/16/2010
Paul T Finger, Kimberly J Chin, Guo-Pei Yu, Neil S Patel, Palladium-103 for Choroidal Melanoma Study Group Risk factors for cataract after palladium-103 ophthalmic plaque radiation therapy CONCLUSIONS: Although anterior tumor location, greater tumor height, and increased patient age (at treatment) were associated with significantly greater risk for radiation cataract, dose to lens was the most significant factor. 7/10/2010
Neil Patel, Melissa Dodsworth, John F Mills Cardiac output measurement in newborn infants using the ultrasonic cardiac output monitor an assessment of agreement with conventional echocardiography, repeatability and new user experience CONCLUSIONS: Repeatability of USCOM measures is high in newborn infants. New users can be trained quickly, but with high inter-user variability. Agreement between USCOM and conventional ECHO is broad, and worse for RVO and LVO. Further studies are required to assess the ability of the device to dete... 7/8/2010
Neil N Patel, Francesco T Mangano, Paul Klimo Indirect revascularization techniques for treating moyamoya disease There have been many indirect revascularization techniques described by surgeons for the treatment of moyamoya disease. These surgical procedures are typically used more commonly in pediatric, than in adults', cases. Some of the techniques include: cervical sympathectomy, omental transplantation, mu... 6/22/2010
Michael G Miller, Christopher C Cheatham, Neil D Patel Resistance training for adolescents The benefits and possible detriment of resistance training have been noted extensively in the literature. Although the benefits of resistance training are well known, many professionals fail to heed scientific advice or follow appropriate recommendations for resistance training in adolescents. When ... 6/12/2010
Ameer E Hassan, Bahareh Hassanzadeh, Vahid Tohidi, Jawad F Kirmani Very mild stroke patients benefit from intravenous tissue plasminogen activator without increase of intracranial hemorrhage CONCLUSION: This retrospective study demonstrates that administering intravenous rt-PA to patients with a very mild stroke (NIHSS of 6 or less) can lead to improved clinical outcome when compared to patients with similar NIHSS who have not received similar treatment. 4/9/2010
Rushika Fernandopulle, Neil Patel How the electronic health record did not measure up to the demands of our medical home practice The American Recovery and Reinvestment Act (ARRA) of 2009 will soon provide billions of dollars to small physician practices nationwide to encourage adoption of electronic health records. Although shifting from paper to computers should lead to better and cheaper care, the transition is complex. In ... 4/7/2010
Norma I Cruz, Fanor M Saavedra Preservation of nonviable cranial bone after class IV electrical burns CONCLUSIONS: Even with moderately delayed management of contaminated electrical burns, partial excision of the necrotic bone with burr holes and flap coverage appears to be adequate. 3/13/2010
Ameer E Hassan, Haralabos Zacharatos, Bahareh Hassanzadeh, Ahmed El-Gengaihy, Ammar AlKawi, Akram Shhadeh, Jawad F Kirmani Does mild deficit for patients with stroke justify the use of intravenous tissue plasminogen activator Intravenous (IV) tissue plasminogen activator (t-PA) is an effective medication currently used to treat acute ischemic stroke within 3 hours of symptom onset in patients with an identifiable clinical deficit measured using the National Institutes of Health Stroke Scale (NIHSS). Some reports suggest ... 3/2/2010
Jacob A Akoh, Neil Patel Infection of hemodialysis arteriovenous grafts CONCLUSION: Infectious complications of AVG require prompt surgical or radiological intervention to save life or access. The need to excise an infected graft completely is sometimes counterbalanced by the compelling need to provide vascular access for hemodialysis in a patient with limited access op... 2/23/2010
Robert J Stein, Neil S Patel, Kyle Quinn, Milton Berger, Walter Koff, Gaurang Shah, Monish Aron, Andre K Berger Laparoscopic ureterolysis with omental wrap for idiopathic retroperitoneal fibrosis CONCLUSIONS: Ureterolysis can be a challenging operation depending on the extent of the retroperitoneal mass. An understanding of various laparoscopic techniques can provide the flexibility for successful completion of nearly all of these procedures using a minimally invasive approach. 2/5/2010
Richard T Addo, Aladin Siddig, Rodney Siwale, Neil J Patel, Janet Akande, Akm N Uddin, Martin J D'Souza Formulation, characterization and testing of tetracaine hydrochloride-loaded albumin-chitosan microparticles for ocular drug delivery Most ocular surgical procedures take approximately 60 min to complete, the anaesthetic property of the safest drug, tetracaine, is initiated in a few minutes and lasts approximately 10-15 min. The purpose of the present study was to develop an ocular tetracaine formulation which can produce an immed... 1/9/2010
Bo Hong, Neil V Patel, Matthew J Gounis, Michael J DeLeo, Italo Linfante, Joan C Wojak, Ajay K Wakhloo Semi-jailing technique for coil embolization of complex, wide-necked intracranial aneurysms CONCLUSION: Semi-jailing is a safe and effective stent-assisted coiling technique that facilitates treatment of complex, wide-necked aneurysms. 11/26/2009
Lindsey E Romick-Rosendale, Aaron M Goodpaster, Philip J Hanwright, Neil B Patel, Esther T Wheeler, Deepika L Chona, Michael A Kennedy NMR-based metabonomics analysis of mouse urine and fecal extracts following oral treatment with the broad-spectrum antibiotic enrofloxacin Baytril The human gastrointestinal tract is home to hundreds of species of bacteria and the balance between beneficial and pathogenic bacteria plays a critical role in human health and disease. The human infant, however, is born with a sterile gut and the complex gastrointestinal host/bacterial ecosystem is... 9/22/2009
Robert J Stein, Burak Turna, Neil S Patel, Christopher J Weight, Mike M Nguyen, Gaurang Shah, Monish Aron, Amr F Fergany, Inderbir S Gill, Mihir M Desai Laparoscopic assisted ileal ureter technique, outcomes and comparison to the open procedure CONCLUSIONS: Despite the small number of subjects involved a significant advantage was noted for postoperative recovery after laparoscopic compared to open ileal interposition. A detailed understanding of this complicated procedure can help prevent inherent pitfalls. 7/21/2009
Xuanyang Li, Jennifer Slife, Neil Patel, Shaying Zhao Stepwise evolution of two giant composite LTR-retrotransposon-like elements DA and Xiao CONCLUSION: The study has led to a more accurate age determination of the DA and Xiao elements than our previous bioinformatics analyses, and indicates that the amplification activity of the elements coincided with that of group I HERV-Es during evolution. It has also illustrated an evolutionary pat... 6/9/2009
Vahid Tohidi, Farzan Nadim Membrane resonance in bursting pacemaker neurons of an oscillatory network is correlated with network frequency Network oscillations typically span a limited range of frequency. In pacemaker-driven networks, including many central pattern generators (CPGs), this frequency range is determined by the properties of bursting pacemaker neurons and their synaptic connections; thus, factors that affect the burst fre... 5/22/2009
Laura McGlone, Neil Patel, David Young, Mark D Danton Impaired cardiac autonomic nervous control after cardiac bypass surgery for congenital heart disease We undertook a study to describe changes in heart rate variability (HRV) postoperatively in children undergoing cardiac bypass surgery for congenital heart disease (CHD). HRV was recorded for a 1-h period preoperatively and a 24-h period postoperatively in 20 children with CHD. We found a highly sig... 5/21/2009
Neil Patel, John F Mills, Michael M H Cheung Assessment of right ventricular function using tissue Doppler imaging in infants with pulmonary hypertension CONCLUSIONS: TDI permits non-invasive assessment of RV myocardial velocities in infants. Reduced systolic and diastolic velocities in PHT may represent impaired systolic contraction and early diastolic relaxation. Therapies which target inotropic and lusitropic function may be appropriate in infants... 5/2/2009
Jason T Siegel, Eusebio M Alvaro, Neil Patel, William D Crano you would probably want to do it Cause thats what made them popular Exploring perceptions of inhalant utility among young adolescent nonusers and occasional users With an eye toward future primary prevention efforts, this study explores perceptions of inhalant utility among young adolescents in the United States. The study makes use of data gathered via nine focus groups conducted in Tucson, Arizona in 2004 (N = 47, mean age = 13.2 years). Three main themes e... 4/11/2009
Rongxiu Li, Yan Zang, Changyou Li, Neil S Patel, Jennifer R Grandis, Daniel E Johnson ABT-737 synergizes with chemotherapy to kill head and neck squamous cell carcinoma cells via a Noxa-mediated pathway Overexpression of Bcl-X(L), an antiapoptotic Bcl-2 family member, occurs in a majority of head and neck squamous cell carcinomas (HNSCCs) and correlates with chemotherapy resistance in this disease. Overexpression of Bcl-2 is also observed in HNSCC, albeit less frequently. We have previously shown t... 2/28/2009
Lenay Santana, Amparo Gutierrez Neuralgic amyotrophy Neuralgic amyotrophy has a broad variety of clinical manifestations. Although it was initially thought to be a plexopathy, its diverse presentation can include isolated sensory nerves or even cranial nerves. Although neuralgic amyotrophy is usually a benign condition with a good recovery, pain can b... 2/13/2009
Robert A Hirschl, Jeff Wilson, Brandon Miller, Sergio Bergese, E Antonio Chiocca The predictive value of low-field strength magnetic resonance imaging for intraoperative residual tumor detection Clinical article CONCLUSIONS: These data could assist the neurosurgeon who has to decide intraoperatively whether the observed iMR images show residual tumor or not. 2/10/2009
Jonathan D Drover, Vahid Tohidi, Amitabha Bose, Farzan Nadim Combining synaptic and cellular resonance in a feed-forward neuronal network We derive a mathematical theory to explain the subthreshold resonance response of a neuron to synaptic input. The theory shows how a neuron combines information from its intrinsic resonant properties with those of the synapse to determine the neuron's generalized resonance response. Our results show... 12/17/2008
Alon A Gorodetsky, William J Hammond, Michael G Hill, Krzysztof Slowinski, Jacqueline K Barton Scanning electrochemical microscopy of DNA monolayers modified with Nile Blue Scanning electrochemical microscopy (SECM) is used to probe long-range charge transport (CT) through DNA monolayers containing the redox-active Nile Blue (NB) intercalator covalently affixed at a specific location in the DNA film. At substrate potentials negative of the formal potential of covalentl... 12/5/2008
Dilip R Patel, Helen D Pratt, Neil D Patel Team processes and team care for children with developmental disabilities Professionals who work with children and adolescents who have developmental disabilities find themselves working with several other professionals on various "teams." These teams are typically composed of practitioners from more than one discipline working toward the single goal of providing comprehe... 12/2/2008
Joel R Martin, Mark L Latash, Vladimir M Zatsiorsky Interaction of finger enslaving and error compensation in multiple finger force production Previous studies have documented two patterns of finger interaction during multi-finger pressing tasks, enslaving and error compensation, which do not agree with each other. Enslaving is characterized by positive correlation between instructed (master) and non-instructed (slave) finger(s) while erro... 11/6/2008
Neil Patel, John F Mills, Michael M H Cheung Use of the myocardial performance index to assess right ventricular function in infants with pulmonary hypertension CONCLUSIONS: In infants, RVMPI allows quantification of right ventricular function and detection of RV dysfunction in PHT. No linear relationship exists between RVMPI pulmonary artery pressure. Use of RVMPI in the clinical setting must take into account the global and load-dependent nature of this m... 8/16/2008
Jason T Siegel, Eusebio M Alvaro, William D Crano, Jessica Skenderian, Andrew Lac, Neil Patel Influencing inhalant intentions by changing socio-personal expectations This study investigates an approach for reducing inhalant initiation among younger adolescents: altering Socio-Personal Expectations (SPEs), a term referring to perceived linkages between behavior and personally relevant social outcomes. The study focuses specifically on SPEs regarding outcomes asso... 6/11/2008
Lisa S Thibodeaux, Amparo Gutierrez Management of symptoms in amyotrophic lateral sclerosis The mainstay of treatment of amyotrophic lateral sclerosis (ALS) is management of symptoms. Health care providers involved in the care of ALS patients should be armed with the most current knowledge about symptomatic management of these patients so that an aggressive approach to controlling symptoms... 3/13/2008
William D Crano, Jason T Siegel, Eusebio M Alvaro, Neil M Patel Overcoming adolescents resistance to anti-inhalant appeals This research was concerned with factors that affect adolescents' evaluations of persuasive anti-inhalant messages and the association of these evaluations with usage intentions. Sixth and 7th graders (N=894) received anti-inhalant messages that varied as a result of the factorial combination of mes... 12/13/2007
Neil D Patel, Ravi K Trehan Acute isolated acetabular fracture following a game of squash a case report Although hip injuries do not account a large amount of the Sports Physician's workload they can result in significant morbidity. We present a case where an acetabular fracture was sustained in a relatively young female while playing squash without any history of fall or injury but was treated succe... 11/30/2007
Jay A Vachhani, William A Friedman Radiosurgery in patients with bilateral vestibular schwannomas CONCLUSION: In all but 1 patient with follow-up data, radiosurgery successfully prevented or reversed tumor growth. Additionally, half of the untreated tumors continued to grow. This study shows that radiosurgery alters the natural history of vestibular schwannomas. 8/22/2007
Atchar Sudhyadhom, Frank J Bova, Kelly D Foote, Christian A Rosado, Lindsey Kirsch-Darrow, Michael S Okun Limbic, associative, and motor territories within the targets for deep brain stimulation potential clinical implications The use of deep brain stimulation (DBS) has recently been expanding for the treatment of many neurologic disorders such as Parkinson disease, dystonia, essential tremor, Tourette's syndrome, cluster headache, epilepsy, depression, and obsessive compulsive disorder. The target structures for DBS incl... 7/10/2007
Zornitza Stark, Neil Patel, Tom Clarnette, Amanda Moody Triad of tracheoesophageal fistula-esophageal atresia, pulmonary hypoplasia, and duodenal atresia We describe 3 cases of tracheoesophageal fistula with esophageal atresia who also had right pulmonary hypoplasia-aplasia and duodenal atresia. We review the current literature and propose that this may be a distinct association. 6/15/2007
Donato M Ceres, Andrew K Udit, Haley D Hill, Michael G Hill, Jacqueline K Barton Differential ionic permeation of DNA-modified electrodes Ionic permselectivity of DNA films has been investigated by the analysis of the electrochemical response of methylene blue (MB) as a function of pH and ionic strength on DNA-modified electrodes in aqueous p-nitrophenol (p-NP) and phosphate buffers. We have observed a linear Pourbaix diagram in p-NP ... 1/19/2007
Andrew K Udit, Michael G Hill, Harry B Gray Electrochemistry of cytochrome P450 BM3 in sodium dodecyl sulfate films Direct electrochemistry of the cytochrome P450 BM3 heme domain (BM3) was achieved by confining the protein within sodium dodecyl sulfate (SDS) films on the surface of basal-plane graphite (BPG) electrodes. Cyclic voltammetry revealed the heme FeIII/II redox couple at -330 mV (vs Ag/AgCl, pH 7.4). Up... 11/30/2006
John Graff-Radford, Kelly D Foote, Ramon L Rodriguez, Hubert H Fernandez, Robert A Hauser, Atchar Sudhyadhom, Christian A Rosado, Justin C Sanchez, Michael S Okun Deep brain stimulation of the internal segment of the globus pallidus in delayed runaway dyskinesia CONCLUSION: This case highlights the delayed development of runaway dyskinesia after a period without medication as an important potential long-term adverse effect of embryonic cell transplantation in patients with Parkinson disease. 8/16/2006
Andrew K Udit, Katharine D Hagen, Peter J Goldman, Andrew Star, James M Gillan, Harry B Gray, Michael G Hill Spectroscopy and electrochemistry of cytochrome P450 BM3-surfactant film assemblies We report analyses of electrochemical and spectroscopic measurements on cytochrome P450 BM3 (BM3) in didodecyldimethylammonium bromide (DDAB) surfactant films. Electronic absorption spectra of BM3-DDAB films on silica slides reveal the characteristic low-spin FeIII heme absorption maximum at 418 nm.... 8/3/2006
Adrian H I Sie, Neil Patel, Neil Spenceley Neonatal urinary ascites in renal candidal infection A preterm neonate developed anuria and abdominal distension. Peritoneal fluid contained high levels of potassium, urea and creatinine with a low level of bicarbonate compared with plasma. Renal ultrasound showed dilatation of the left collecting system with echogenic material in the calyces bilatera... 6/2/2006
Janice H Urban, Randy J Leitermann, M Regina DeJoseph, Suwit J Somponpun, Michael L Wolak, Celia D Sladek Influence of dehydration on the expression of neuropeptide Y Y1 receptors in hypothalamic magnocellular neurons Regulation of vasopressin (VP) and oxytocin (OT) secretion involves integration of neural signals from hypothalamic osmoreceptors, ascending catecholaminergic and peptidergic cell groups in the brain stem, and local and autoregulatory afferents. Neuropeptide Y (NPY) is one factor that stimulates the... 5/27/2006
Melissa Colón-Cesario, Jianpeng Wang, Xiomara Ramos, Hermes G García, Jorge J Dávila, Jessenia Laguna, Claribel Rosado, Sandra Peña de Ortiz An inhibitor of DNA recombination blocks memory consolidation, but not reconsolidation, in context fear conditioning Genomic recombination requires cutting, processing, and rejoining of DNA by endonucleases, polymerases, and ligases, among other factors. We have proposed that DNA recombination mechanisms may contribute to long-term memory (LTM) formation in the brain. Our previous studies with the nucleoside analo... 5/19/2006
Andrew K Udit, Michael G Hill, Harry B Gray Electrochemical generation of a high-valent state of cytochrome P450 Cyclic voltammetry performed at rapid scan rates on cytochrome P450 from Pseudomonas putida (P450CAM) in didodecyldimethylammonium bromide (DDAB) films on graphite electrodes revealed a couple (E) at 830mV (vs Ag/AgCl). E was not significantly observed at scan rates less than 30V/s at room temperatu... 3/1/2006
Serena DeBeer George, Lipika Basumallick, Robert K Szilagyi, David W Randall, Michael G Hill, Aram M Nersissian, Joan S Valentine, Britt Hedman, Keith O Hodgson, Edward I Solomon Spectroscopic investigation of stellacyanin mutants axial ligand interactions at the blue copper site Detailed electronic and geometric structural descriptions of the blue copper sites in wild-type (WT) stellacyanin and its Q99M and Q99L axial mutants have been obtained using a combination of XAS, resonance Raman, MCD, EPR, and DFT calculations. The results show that the origin of the short Cu-S(Cys... 10/14/2005
Andrew K Udit, Wendy Belliston-Bittner, Edith C Glazer, Yen Hoang Le Nguyen, James M Gillan, Michael G Hill, Michael A Marletta, David B Goodin, Harry B Gray Redox couples of inducible nitric oxide synthase We report direct electrochemistry of the iNOS heme domain in a DDAB film on the surface of a basal plane graphite electrode. Cyclic voltammetry reveals FeIII/II and FeII/I couples at -191 and -1049 mV (vs Ag/AgCl). Imidazole and carbon monoxide in solution shift the FeIII/II potential by +20 and +62... 8/11/2005
Maria B Weimer, Amparo Gutierrez, Gary B Baskin, Juan T Borda, Ronald S Veazey, Leann Myers, Kathrine M Phillippi-Falkenstein, Bruce A Bunnell, Marion S Ratterree, John D England Serial electrophysiologic studies in rhesus monkeys with Krabbe disease Krabbe disease is a progressive leukodystrophy that results in demyelination in the central and peripheral nervous systems in humans. It has been described in a number of mammalian species including the rhesus monkey. We performed serial nerve conduction studies beginning within the first 2 months o... 6/7/2005
Andrew K Udit, Nareen Hindoyan, Michael G Hill, Frances H Arnold, Harry B Gray Protein-surfactant film voltammetry of wild-type and mutant cytochrome P450 BM3 We are investigating the redox chemistry of wild-type (WT) and mutant (1-12G) cytochrome P450 BM3. Absorption spectra in solution feature the Fe(III) Soret at 418 nm for WT and a split Soret for 1-12G at 390 and 418 nm. Voltammetry of the proteins within DDAPSS films on the surface of carbon electro... 6/7/2005
Kris T Huang, Agnes Keszler, Neil Patel, Rakesh P Patel, Mark T Gladwin, Daniel B Kim-Shapiro, Neil Hogg The reaction between nitrite and deoxyhemoglobin Reassessment of reaction kinetics and stoichiometry Recent evidence suggests that the reaction between nitrite and deoxygenated hemoglobin provides a mechanism by which nitric oxide is synthesized in vivo. This reaction has been previously defined to follow second order kinetics, although variable product stoichiometry has been reported. In this stud... 4/20/2005
T Gregory Drummond, Michael G Hill, Jacqueline K Barton Electron transfer rates in DNA films as a function of tether length A homologous series of DNA-modified electrodes has been investigated in which the molecular tether length varies. Using intercalated, covalently bound daunomycin as a redox probe, an exponential dependence of electron transfer rates on the number of intervening methylene groups in the sigma-bonded t... 11/19/2004
Howard E Savage, Rabindra K Halder, Uladzimir Kartazayeu, Richard B Rosen, Tapan Gayen, Steven A McCormick, Neil S Patel, Alvin Katz, Henry D Perry, Misu Paul, R R Alfano NIR laser tissue welding of in vitro porcine cornea and sclera tissue CONCLUSIONS: We conclude that an NIR laser system using an optimal laser radiation wavelength of 1,455 nm can effectively weld cornea and sclera tissue and that this laser tissue welding (LTW) methodology typically causes minimal disruption of tissue, and thus, avoids opacities and irregularities in... 10/20/2004
Sou-Tung Chiu-Tsao, Tamara Duckworth, Chuanfang Zhang, Neil S Patel, Chih-Yun Hsiung, Lin Wang, J Allen Shih, Louis B Harrison Dose response characteristics of new models of GAFCHROMIC films dependence on densitometer light source and radiation energy This paper presents a systematic study of the dose response characteristics of two new models and one commonly used model of GAFCHROMIC film: HS, XR-T, and MD55-2, respectively. We irradiated these film models with three different radiation sources: I-125, Ir-192, and 6 MV photon beam (6 MVX). We sc... 10/19/2004
James A Fee, Thomas R Todaro, Eugene Luna, Donita Sanders, Laura M Hunsicker-Wang, Kirti M Patel, Kara L Bren, Ester Gomez-Moran, Michael G Hill, Jingyuan Ai, Thomas M Loehr, W Anthony Oertling, Pamela A Williams, C David Stout, Duncan McRee, Andrzej Pastuszyn Cytochrome rC552, formed during expression of the truncated, Thermus thermophilus cytochrome c552 gene in the cytoplasm of Escherichia coli, reacts spontaneously to form protein-bound 2-formyl-4-vinyl Spirographis heme Expression of the truncated (lacking an N-terminal signal sequence) structural gene of Thermus thermophilus cytochrome c(552) in the cytoplasm of Escherichia coli yields both dimeric (rC(557)) and monomeric (rC(552)) cytochrome c-like proteins [Keightley, J. A., et al. (1998) J. Biol. Chem. 273, 120... 9/24/2004
Andrew K Udit, Michael G Hill, V Garrett Bittner, Frances H Arnold, Harry B Gray Reduction of dioxygen catalyzed by pyrene-wired heme domain cytochrome P450 BM3 electrodes We have electronically wired the cytochrome P450 BM3 heme domain to a graphite electrode with the use of a pyrene-terminated tether. AFM images clearly reveal that pyrene-wired enzyme molecules are adsorbed to the electrode surface. The enzyme-electrode system undergoes rapid and reversible electron... 8/19/2004
Neil S Patel, Sou-Tung Chiu-Tsao, J Allen Shih, Yunsil Ho, Hung-Sheng Tsao, Louis B Harrison Treatment planning dosimetric parameters for 192Ir seed at short distances effects of air channels and neighboring seeds based on Monte Carlo study The dose distributions around two different arrangements of a single radioactive 192Ir seed in water, (1) with air channels at the ends, and (2) surrounded by two nonactive ("dummy") seeds on both longitudinal ends, were calculated using MCNP4C Monte Carlo simulations at distances up to 1 cm. The co... 7/21/2004
Sou-Tung Chiu-Tsao, Tamara L Duckworth, Neil S Patel, Julianna Pisch, Louis B Harrison Verification of Ir-192 near source dosimetry using GAFCHROMIC film Intravascular brachytherapy treatments of in-stent restenosis have been performed extensively using Ir-192 ribbon. Task Group 60 of the American Association of Physicists in Medicine (AAPM) recommends a dose reference point at 2 mm from the source center for these treatments. However, it is known th... 3/6/2004
Netanya Y Spencer, Neil K Patel, Agnes Keszler, Neil Hogg Oxidation and nitrosylation of oxyhemoglobin by S-nitrosoglutathione via nitroxyl anion The reaction between low molecular weight S-nitrosothiols and hemoglobin is often used to synthesize S-nitrosohemoglobin, a form of hemoglobin suggested to be involved in the regulation of vascular oxygen delivery. However, this reaction has not been studied in detail, and several groups have report... 12/4/2003
Xiaodong Shu, Karen Cheng, Neil Patel, Fuhua Chen, Elaine Joseph, Huai-Jen Tsai, Jau-Nian Chen Na,K-ATPase is essential for embryonic heart development in the zebrafish Na,K-ATPase is an essential gene maintaining electrochemical gradients across the plasma membrane. Although previous studies have intensively focused on the role of Na,K-ATPase in regulating cardiac function in the adults, little is known about the requirement for Na,K-ATPase during embryonic heart ... 11/7/2003
T Gregory Drummond, Michael G Hill, Jacqueline K Barton Electrochemical DNA sensors Electrochemistry-based sensors offer sensitivity, selectivity and low cost for the detection of selected DNA sequences or mutated genes associated with human disease. DNA-based electrochemical sensors exploit a range of different chemistries, but all take advantage of nanoscale interactions between ... 10/2/2003
Xiuli Xu, Man Cho, Netanya Y Spencer, Neil Patel, Zhi Huang, Howard Shields, S Bruce King, Mark T Gladwin, Neil Hogg, Daniel B Kim-Shapiro Measurements of nitric oxide on the heme iron and beta-93 thiol of human hemoglobin during cycles of oxygenation and deoxygenation Nitric oxide has been proposed to be transported by hemoglobin as a third respiratory gas and to elicit vasodilation by an oxygen-linked (allosteric) mechanism. For hemoglobin to transport nitric oxide bioactivity it must capture nitric oxide as iron nitrosyl hemoglobin rather than destroy it by dio... 9/23/2003
Sou-Tung Chiu-Tsao, Tamara L Duckworth, Chih-Yun Hsiung, Zuofeng Li, Jeffrey Williamson, Neil S Patel, Louis B Harrison Thermoluminescent dosimetry of the SourceTech Medical model STM1251 125I seed Many new models of 125I seeds are being introduced, mainly due to the increase in prostate seed implants. We have evaluated the SourceTech Medical (STM), model STM1251, 125I seed using thermoluminescent dosimeters (TLDs) in a solid water phantom. TLD cubes, LiF TLD-100, with dimension 1 mm on each e... 8/9/2003
Michael L Wolak, M Regina DeJoseph, Allison D Cator, Ashwini S Mokashi, Mark S Brownfield, Janice H Urban Comparative distribution of neuropeptide Y Y1 and Y5 receptors in the rat brain by using immunohistochemistry Neuropeptide Y (NPY) Y1 and Y5 receptor subtypes mediate many of NPY's diverse actions in the central nervous system. The present studies use polyclonal antibodies directed against the Y1 and Y5 receptors to map and compare the relative distribution of these NPY receptor subtypes within the rat brai... 8/6/2003
Corinna R Hess, Gregory A Juda, David M Dooley, Ricky N Amii, Michael G Hill, Jay R Winkler, Harry B Gray Gold electrodes wired for coupling with the deeply buried active site of Arthrobacter globiformis amine oxidase Diethylaniline-terminated oligo(phenyl-ethynyl)-thiol (DEA-OPE-SH) wires on Au-bead electrodes facilitate electron tunneling to and from the deeply buried topaquinone (TPQ) cofactor in Arthrobacter globiformis amine oxidase (AGAO). Reversible cyclic voltammograms were observed when AGAO was adsorbed... 6/12/2003
Neil S Patel, Sou-Tung Chiu-Tsao, Yunsil Ho, Tamara Duckworth, J Allen Shih, Hung-Sheng Tsao, Harry Quon, Louis B Harrison High beta and electron dose from 192Ir implications for gamma intravascular brachytherapy CONCLUSION: 192Ir multiple seed trains used in the SCRIPPS, GAMMA, and WRIST trials can deposit a very high dose to the luminal wall. A particularly high electron and beta dose can be delivered near the interseed gap if the source is not centered in the catheter and lumen. The dose from 192Ir betas ... 10/16/2002
Akiko Maehara, Neil S Patel, Louis B Harrison, Neil J Weissman, Anh B Bui, Han-Soo Kim, Andrew E Ajani, Marco T Castagna, Taya L McMillan, Nathan Yang, Rosanna Chan, Julliana Pisch, Harry Quan, Sou-Tung Chiu-Tsao, Ron Waksman, Gary S Mintz Dose heterogeneity may not affect the neointimal proliferation after gamma radiation for in-stent restenosis a volumetric intravascular ultrasound dosimetric study CONCLUSIONS: Although there may be large dose heterogeneity, gamma irradiation (using a fixed dose prescription) appears to deliver a sufficient dose to prevent neointimal regrowth. 6/27/2002
V S Pai, Neil Patel Atypical coronal or sagittal Z ruptures of the achilles tendon a report of four cases A typical rupture of Achilles tendon occurs as a complete rupture about 4-6 cm proximal to its insertion to the calcaneus. The morphology of the tear is most often random without any distinct recognizable pattern. The authors describe four cases of atypical "Z" rupture of the Achilles tendon. In two... 6/22/2002
Vincent J. Catalano, Ryan A. Heck, Chad E. Immoos, Anna Öhman, Michael G. Hill Steric Modulation of Electrocatalytic Benzyl Alcohol Oxidation by RutrpyR2dppiO2 Complexes The complexes [Ru(trpy)(H(2)dppi)Cl](+) (1a), [Ru(trpy)(Me(2)dppi)Cl](+) (1b), and [Ru(trpy)(Cl(2)dppi)Cl](+) (1c), where trpy is 2,2',2"-terpyridine, H(2)dppi is 3,6-bis(pyrid-2-yl)pyridazine, Me(2)dppi is 3,6-bis(6-methylpyrid-2-yl)pyridazine, and Cl(2)dppi is 3,6-bis(6-chloropyrid-2-yl)pyridazine... 10/24/2001
Sudhir Achar, Chad E. Immoos, Michael G. Hill, Vincent J. Catalano Synthesis, Characterization, and Electrochemistry of Heterometallic Dendrimers A method for the synthesis of new heterometallic dendritic molecules containing organoplatinum centers is reported. Reaction of Pt(2)Me(4)(&mgr;-SMe(2))(2) with bpy-Fc(2) (1) (bpy-Fc(2) = 4,4'-bis(ferrocenylvinyl)-2,2'-bipyridine) gave the platinum(II) complex PtMe(2)(bpy-Fc(2)) (2). Complex 2 under... 5/21/1997

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