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| Author(s) | Title | Description | Publish Date |
|---|---|---|---|
| Sleep Disturbance and Chronic Urticaria A Narrative Review of Its Relationship, Treatment and Evolving Literature | CONCLUSION: The article emphasizes the significance of recognizing the impact of sleep disturbances on chronic urticaria. It lays the groundwork for future research to expand our understanding of this association, ultimately leading to improved management strategies and improved QoL for affected ind... | 5/7/2025 | |
| CSF-venous fistulae-An underrecognized cause of superficial siderosis | Superficial siderosis (SS) of the central nervous system is a rare chronic neurological disorder characterized by hemosiderin deposition over the subpial surface of the brain, cranial nerves, and spinal cord. This deposition can result from acute subarachnoid hemorrhage or from chronic or repeated h... | 5/6/2025 | |
| Higher risk of recurrence in partially thrombosed cerebral aneurysms post-WEB Woven EndoBridge device treatment insights from the WorldWideWEB Consortium registry | CONCLUSION: Partially thrombosed aneurysms are associated with a poorer occlusion rate and a higher rate of retreatment following WEB embolization. For partially thrombosed aneurysms, the WEB device appears suboptimal as a first-line treatment, and therefore alternative techniques should be prioriti... | 4/30/2025 | |
| Impact of Iron Deficiency Anemia on Postoperative Outcomes of Thoracolumbar Spinal Fusion 2 levels on Patients with Adult Spinal Deformity with Minimum 2-Year Follow-Up | CONCLUSIONS: Baseline IDA was predictive of increased wound complications, postoperative blood transfusion, and overall surgical complications after thoracolumbar fusion surgery for ASD. Our findings could inform potential medical interventions to mitigate the risks of adverse outcomes in patients w... | 4/14/2025 | |
| Long-Term Outcomes of Adult Temporal Bone Fractures With Hearing Loss Results of a Multinational Database Analysis | CONCLUSION: Adults who sustain TBFs resulting in HL have an increased risk of developing meningitis, labyrinthitis, CSF leak, and FND and are more likely to undergo CI for aural rehabilitation compared to a control cohort. | 4/9/2025 | |
| Corrigendum to Persistent hiccups following thalamic hemorrhage A case report Heliyon Volume 9, Issue 6, June 2023, Article e16409 | [This corrects the article DOI: 10.1016/j.heliyon.2023.e16409.]. | 4/9/2025 | |
| Developing Therapeutically Enhanced Extracellular Vesicles for Atherosclerosis Therapy | Atherosclerosis is a chronic condition and the leading cause of death worldwide. While statin therapy is the clinical standard, many patients still experience acute cardiovascular events. To develop better therapies, the group previously delivered microRNA-145 (miR-145) via micellar nanoparticles to... | 4/7/2025 | |
| Evaluation of AI Summaries on Interdisciplinary Understanding of Ophthalmology Notes | CONCLUSIONS AND RELEVANCE: In this study, use of LLM-generated PLSs was associated with enhanced comprehension and satisfaction among nonophthalmology clinicians and professionals, which might aid interdisciplinary communication. Careful implementation and safety monitoring are recommended for clini... | 4/3/2025 | |
| Why Consider Aspirin for the Treatment of Vestibular Schwannoma A Brief Review and Randomized, Double-Blind, Placebo-Controlled Study Proposal | CONCLUSIONS: Completion of a robust study design is necessary. The current aspirin dose has been well tolerated, with minimal adverse events to date. | 4/2/2025 | |
| Increased circulating Endothelin-1 is a risk factor for ECMO use and mortality in neonates with congenital diaphragmatic hernia a prospective observational study | CONCLUSIONS: Elevated ET-1 levels during the first 48 h of life in CDH neonates are significantly associated with increased rates of ECMO and mortality. These findings underline the potential of ET-1 as a predictive biomarker for poor outcomes in CDH and highlight its relevance in guiding therapeuti... | 3/22/2025 | |
| Prediction of persistent incomplete occlusion of intracranial aneurysms treated with woven EndoBridge device | While the Woven EndoBridge (WEB) device has transformed the treatment of wide-neck intracranial aneurysms, incomplete occlusion remains a significant challenge requiring better understanding of contributing factors. A retrospective analysis was conducted on multicenter data from patients who underwe... | 3/22/2025 | |
| Electrode-Mediated Photochemical Disproportionation of a PolypyridylrutheniumII Chromophore | On a metallic electrode embedded within a Nafion film, excitation at 470 nm of Ru(bpy)(2)(dppn)^(2+) (bpy = 2,2'-bipyridine; dppn = benzo[i]dipyrido[3,2-a:2',3'-c]phenazine) produced photocurrents indicative of tunable charge transfer between the electrode and photosensitizer, with the direction and... | 3/21/2025 | |
| Hemodynamic precision to guide surgical timing for neonates with congenital diaphragmatic hernia a narrative review | Despite a near universal approach focused on physiologic stabilization prior to surgical repair of congenital diaphragmatic hernia (CDH), a condition with significant morbidity and mortality, there remains a lack of consensus, or even guidance, on the appropriate timing for diaphragmatic reconstruct... | 3/20/2025 | |
| The relationship between cardiorespiratory fitness and firefighter occupational performance a systematic review and meta-analysis examining absolute versus relative VOsub2maxsub | Unequivocally greater cardiorespiratory fitness (CRF) is beneficial for performing firefighting occupational tasks (OTs); however, the contribution of absolute vs. relative VO(2max) with OT performance warrants further study. This systematic review and meta-analysis compared the relationship between... | 3/17/2025 | |
| Hearing Benefits of Cochlear Implantation in Older Adults With Asymmetric Hearing Loss | CONCLUSIONS: In this group of older adults with SSD or AHL, CI demonstrated significant benefits in hearing thresholds and speech recognition in the implanted ear. Moreover, the average of 9.3 hours of daily use suggests that patients' CI is tolerated and beneficial in this population. | 3/13/2025 | |
| Elicited emotion effects of inoculation of an art style on emotionally strong images | The objective of this research is to study how the application of the Convolutional Neural Network (CNN) artistic filter can be an alternative to mitigate the emotional response to photographs with strong emotional content published in Internet news. Van Gogh's artistic style was extracted through a... | 3/12/2025 | |
| Effect of fusion and arthroplasty for cervical degenerative disc disease in patients with physically demanding occupations | CONCLUSION: CDA may facilitate faster work return, better recovery, and lower ASD risk in labor-intensive patients. WC status correlates with delayed recovery, suggesting a need for tailored approaches. Further research is necessary to confirm these findings and refine patient selection. | 3/7/2025 | |
| Real-Time Tracking of Photoinduced Metal-Metal Bond Formation in a dsup8supdsup8sup Di-Iridium Complex by Vibrational Coherence and Femtosecond Stimulated Raman Spectroscopy | We report real-time dynamics of photoinduced metal-metal bond formation acquired from ultrafast time-resolved stimulated emission and femtosecond stimulated Raman spectra (FSRS) of [Ir(2)(2,5-dimethyl-2,5-diisocyanohexane)(4)]^(2+) (Ir(TMB)) in the region of low-frequency vibrations. Interpretation ... | 3/6/2025 | |
| Incidence and predictors of Woven EndoBridge WEB shape modification following treatment of intracranial aneurysms in a large multicenter study | The Woven EndoBridge (WEB) device is FDA-approved for the treatment of bifurcation aneurysms. Despite its wide popularity, it has been under scrutiny for its association with potential aneurysm recanalization and retreatment due to device shape modification. This study aims to analyze the shape modi... | 2/24/2025 | |
| Bosentan as adjunctive therapy in neonates with congenital diaphragmatic hernia-associated pulmonary hypertension a case series | CONCLUSION: Bosentan is effective in the treatment of neonates with CDH-PH and was associated with improved PH severity and respiratory status. Adverse effects were minimal and consistent with previous studies. | 2/13/2025 | |
| Access to Cochlear Implantation Trends in Surgeon Volume and Training | CONCLUSION: 88% of high-volume CI surgeons have fellowship training in O&N. To meet the current state of CI underutilization and anticipated growing population of CI candidates, we propose increasing the surgical capacity of O&N providers and the number of surgeons proficient in CIs. | 2/11/2025 | |
| Optimal Timing of Primary Radiosurgical Treatment of Growing Vestibular Schwannoma Insights From Salvage Microsurgery Outcomes | CONCLUSION: Corroborated by size threshold surveillance data informing the timing of primary microsurgical resection, the current study suggests that VS outcomes are optimized when primary radiosurgical intervention is undertaken on growing tumors when they harbor 10-15 mm of cerebellopontine angle ... | 2/10/2025 | |
| Impact of smoking on recurrence rates among wide-neck intracranial aneurysms treated with Woven EndoBridge a multicenter retrospective study | CONCLUSIONS: This large-scale study suggests no significant correlation between smoking and the recurrence of IAs treated with the WEB device. Biological studies are warranted to better understand the biological impact of smoking on the growth and rupture of treated IAs. | 1/31/2025 | |
| Transcatheter Stenting to Restore Cross-Sectional Area of Extracardiac Fontan Conduits | CONCLUSIONS: Stent implantation can safely and effectively restore EFC CSA. In select cases, conduits can be expanded beyond the stated diameter. | 1/31/2025 | |
| Erratum U1 Adaptor Oligonucleotides Targeting emBCL2em and emGRM1em Suppress Growth of Human Melanoma Xenografts emIn Vivoem | [This corrects the article DOI: 10.1038/mtna.2013.24.]. | 1/16/2025 | |
| Regenerative Therapy in Pain | Regenerative medicine has been in existence for many decades, and many therapies have received United States Food and Drug Administration (FDA) approval for wound healing and orthopedic applications. Regenerative medicine is a field that applies biological science principles to promote regeneration ... | 1/1/2025 | |
| Long-term outcomes of pediatric temporal bone fractures with hearing loss Results of a multinational database analysis | INTRODUCTION: Pediatric temporal bone fractures (TBFs) can result in adverse outcomes including meningitis, significant sensorineural hearing loss requiring cochlear implantation (CI), facial nerve weakness, cerebrospinal fluid (CSF) leak, and labyrinthitis. The objective of this study is to determi... | 12/25/2024 | |
| Age-related remodeling of the vocal fold extracellular matrix composition, structure, and biomechanics during tissue maturation | CONCLUSION: This work identifies changes in VF ECM composition and organization during tissue maturation, focusing on proteins that regulate collagen fibrillogenesis, fiber assembly, and VF biomechanics. These findings may inform the development of pro-reparative therapies designed to influence coll... | 12/12/2024 | |
| Long-term clinical and safety outcomes from a single-site phase 1 study of neural stem cell transplantation for chronic thoracic spinal cord injury | We report the long-term results for a phase 1 study of neural stem cell transplantation for chronic spinal cord injury. The trial was registered on ClinicalTrials.gov as NCT01772810. The primary outcome of the trial was to test the feasibility and safety of human spinal cord-derived neural stem cell... | 12/3/2024 | |
| A case of Mycoplasma pneumoniae-induced rash and mucositis with recent influenza vaccination | A 33-year-old female presented with coryzal symptoms, facial swelling, severe haemorrhagic stomatitis, blistering oral mucositis, conjunctival injection and a sparse targetoid rash on the back and face, requiring admission to hospital. She had received the seasonal influenza vaccination 3 days prior... | 12/3/2024 | |
| Is cervical disc arthroplasty an effective treatment option for patients with cervical spondylotic myelopathy A matched cohort analysis compared to anterior cervical discectomy and fusion | CONCLUSIONS: ACDF and CDA had statistically similar complication rates and improvements in myelopathic symptoms. However, patients who underwent CDA had superior PROMs to those who had undergone ACDF. | 11/28/2024 | |
| Adjunctive Middle Meningeal Artery Embolization for Subdural Hematoma | CONCLUSIONS: Among patients with symptomatic subacute or chronic subdural hematoma with an indication for surgical evacuation, middle meningeal artery embolization plus surgery was associated with a lower risk of hematoma recurrence or progression leading to reoperation than surgery alone. Further s... | 11/20/2024 | |
| A mobile app for chronic disease self-management for individuals with low health literacy A multisite randomized controlled clinical trial | The purpose of this study was to evaluate the effects of a mobile app designed to improve chronic disease self-management in patients 40 years and older with low health literacy and who had at least one chronic health condition, and to assess the impact of delivering information at different levels ... | 11/18/2024 | |
| Beyond the Heart The Predictive Role of Coronary Artery Calcium Scoring in Non-Cardiovascular Disease Risk Stratification | Coronary artery calcium scoring (CACS), a non-invasive measure of coronary atherosclerosis, has significantly enhanced cardiovascular (CV) risk assessment and stratification in asymptomatic individuals. More recently, a higher score for CAC has been associated with an increased risk of non-CV diseas... | 11/9/2024 | |
| Defining ideal middle cerebral artery bifurcation aneurysm size for Woven EndoBridge embolization | CONCLUSIONS: This study shows that MCA bifurcation aneurysms ≤ 6.1 mm in width and ≤ 4.6 mm in neck size are significantly better candidates for WEB treatment, leading to improved occlusion status and reduced retreatment rate, which are important considerations when using WEB devices. | 10/11/2024 | |
| Thrombectomy for Stroke With Large Infarct on Noncontrast CT The TESLA Randomized Clinical Trial | CONCLUSIONS AND RELEVANCE: Among patients with a large infarct on noncontrast CT within 24 hours, thrombectomy did not demonstrate improvement in functional outcomes. But the width of the credible interval around the effect estimate includes the possibility of both no important effect and a clinical... | 10/7/2024 | |
| Psoas Muscle Morphology A Novel Classification System and its Anatomic Relationship With Adjacent Neurovascular Structures | CONCLUSION: Class A psoas had the largest modified oblique corridor but the highest proportion of those with a dangerous LLIF trajectory. Class C psoas had the narrowest modified oblique corridor, but no dangerous LLIF trajectories were identified. | 9/25/2024 | |
| Definitions of adverse events associated with extracorporeal membrane oxygenation in children results of an international Delphi process from the ECMO-CENTRAL ARC | Extracorporeal membrane oxygenation (ECMO) is a high-risk and low-volume life support with increasing clinical study. However, heterogenous outcome definitions impede data assimilation into evidence to guide practice. The Academic Research Consortium (ARC), an international collaborative forum commi... | 9/19/2024 | |
| Management of bilateral head and neck paragangliomas at a single-institution across four decades | CONCLUSIONS: Younger patients with bilateral HNPGLs, especially those with JP and CBT, are more often treated with surgery. CBTs have lowest risk of cranial nerve deficits after surgery. | 8/22/2024 | |
| Central Vein Recanalization and Rehabilitation in Pediatric Patients Changing the Paradigm for Chronic Occlusions | CONCLUSIONS: Invasive transcatheter rehabilitation of occluded central veins has the potential to preserve critical access sites and improve the symptoms of venous congestion in pediatric patients. Reinterventions are common for reocclusion, restenosis, and somatic growth. | 8/12/2024 | |
| Transcatheter Pulmonary Valve Replacement A Review of Current Valve Technologies | Transcatheter pulmonary valve replacement was first performed by Dr Philip Bonhoeffer, who implanted a Medtronic Melody valve in a human in 2000. Over the past 2 decades, there have been many advances in transcatheter pulmonary valve technology. This includes the use of the SAPIEN transcatheter hear... | 8/12/2024 | |
| Creation of a predictive calculator to determine adequacy of occlusion of the woven endobridge WEB device in intracranial aneurysms-A retrospective analysis of the WorldWide WEB Consortium database | CONCLUSION: The predictive calculator offers a substantial contribution to the clinical toolkit for estimating the likelihood of adequate intracranial aneurysm occlusion by WEB device embolization. | 8/10/2024 | |
| Treatment of large intracranial aneurysms using the Woven EndoBridge WEB a propensity score-matched analysis | The Woven EndoBridge (WEB) device is primarily used for treating wide-neck intracranial bifurcation aneurysms under 10 mm. Limited data exists on its efficacy for large aneurysms. We aim to assess angiographic and clinical outcomes of the WEB device in treating large versus small aneurysms. We condu... | 7/31/2024 | |
| Off-Label use of Woven EndoBridge device for intracranial brain aneurysm treatment Modeling of occlusion outcome | CONCLUSION: This study found that larger neck diameter and daughter sacs were associated with worse occlusion after WEB therapy for aneurysms. The machine learning approach identified anatomical factors related to occlusion outcomes that may help guide patient selection and monitoring with this tech... | 7/28/2024 | |
| The genomic landscape of lung cancer in never-smokers from the Womens Health Initiative | Over 200,000 individuals are diagnosed with lung cancer in the United States every year, with a growing proportion of cases, especially lung adenocarcinoma, occurring in individuals who have never smoked. Women over the age of 50 comprise the largest affected demographic. To understand the genomic d... | 7/25/2024 | |
| Cardiac function in congenital diaphragmatic hernia | Cardiac function is known to play critical role in the pathophysiological progression and ultimate clinical outcome of patients with congenital diaphragmatic hernia (CDH). While often anatomically normal, the fetal and neonatal heart in CDH can suffer from both right and left ventricular dysfunction... | 7/17/2024 | |
| Predictors of Aneurysm Obliteration in Patients Treated with the WEB Device Results of a Multicenter Retrospective Study | CONCLUSIONS: Intraprocedural occlusion can be used to predict the chance of long-term aneurysm occlusion and the need for retreatment after embolization with a WEB device. Smoking, aneurysm size, and the presence of an aneurysm wall branch are associated with decreased chances of successful treatmen... | 7/8/2024 | |
| Physical fitness profile of a large urban fire department Exploring age and rank dynamics | CONCLUSIONS: Firefighters exhibited diverse levels of PF. Age, not rank, appeared to influence firefighters' PF. The findings that firefighters who were older, female, with poorer body composition are more likely to have lower PF levels highlights the need for individualized PF training to enhance o... | 7/5/2024 | |
| A Chronological Overview of Using Deep Learning for Leukemia Detection A Scoping Review | Leukemia is a rare but fatal cancer of the blood. This cancer arises from abnormal bone marrow cells and requires prompt diagnosis for effective treatment and positive patient prognosis. Traditional diagnostic methods (e.g., microscopy, flow cytometry, and biopsy) pose challenges in both accuracy an... | 7/1/2024 | |
| Risk Factors for Adverse Events in the Fontan Population Does Ventricular Morphology Play a Role | No abstract | 6/28/2024 | |
| Association of Food and Housing Insecurity on Outcomes in Pregnant Patients With Substance Use Disorder | CONCLUSIONS: FI and HI were health-related needs associated with increased anxiety, depression, infant NICU admission, and loss of child custody. | 6/8/2024 | |
| Five historical innovations that have shaped modern otolaryngological surgery | Throughout history, many innovations have contributed to the development of modern otolaryngological surgery, improving patient outcomes and expanding the range of treatment options available to patients. This article explores five key historical innovations that have shaped modern otolaryngological... | 6/3/2024 | |
| Pars plana vitrectomy and scleral-fixated intraocular lenses comparison of Gore-Tex suture and flanged intrascleral haptic fixation techniques | CONCLUSION: Combined PPV and scleral fixation of IOLs with Gore-Tex suture and FIHF resulted in similar improvements in visual acuity. No significant differences in refractive outcome and postoperative complication profiles were noted. | 5/30/2024 | |
| Successful Surgical Extraction of an Embolized Iliac Vein Stent from the Right Heart A Case Report | BACKGROUND Stenting of the iliac vein remains one of the therapeutic options for the treatment of May-Thurner syndrome. Embolization of peripheral venous stents due to improper technique is a feared complication with an estimated incidence of 1% to 3%. Here we describe an interesting case of an embo... | 5/30/2024 | |
| Comparing Approaches for Repair of Superior Semicircular Canal Dehiscence | CONCLUSION: The TM approach for SSCD demonstrates shorter operative times and length of hospital stay. The TM and MCF approaches have comparable audiometric and clinical outcomes. | 5/28/2024 | |
| Second harmonic generation microscopy of electromechanical reshaping on corneal collagen | Refractive errors remain a global health concern, as a large proportion of the world's population is myopic. Current ablative approaches are costly, not without risks, and not all patients are candidates for these procedures. Electromechanical reshaping (EMR) has been explored as a viable cost-effec... | 5/23/2024 | |
| Staged implantation of active transcutaneous bone conduction hearing devices BCHD after explantation of older generation bone anchored hearing aids BAHAs Surgical outcomes and approach to management | CONCLUSION: The transition from a pBCI or tBCI to a novel transcutaneous device is nuanced. Staged pBCI or tBCI explantation and novel BCHD implantation with sufficient time for wound healing is vital. Adjunctive procedures to augment soft tissue in cases of prior attenuation may be required to avoi... | 5/11/2024 | |
| Hearing outcomes following reimplantation of functional legacy cochlear implants | CONCLUSIONS: Reimplantation of a functioning legacy CI result in stability or improvement in auditory performance. All individuals in this series report that they enjoy the new connectivity and programming technologies. As the rate advancement in CI technology continues to increase and newer device ... | 5/4/2024 | |
| Association of preprocedural antiplatelet use with decreased thromboembolic complications for intracranial aneurysms undergoing intrasaccular flow disruption | CONCLUSIONS: The findings of this study suggest that the preprocedural administration of antiplatelets is associated with a reduced likelihood of TECs in patients undergoing treatment with the WEB device for wide-necked bifurcation aneurysms. However, postprocedural antiplatelet use did not show a s... | 5/3/2024 | |
| Adjunctive Use of Bone Growth Stimulation Increases Cervical Spine Fusion Rates in Patients at Risk for Pseudarthrosis | CONCLUSIONS: Adjunctive use of PEMF stimulation provides significant improvements in cervical spine fusion rates in subjects having risk factors for pseudarthrosis. When compared with control subjects that did not use PEMF stimulation, treated subjects showed improved fusion outcomes despite being o... | 4/23/2024 | |
| The 5-factor modified frailty index mFI-5 predicts adverse outcomes after elective anterior cervical discectomy and fusion ACDF | CONCLUSION: mFI-5 score is a quick and viable option for surgeons to use as an assessment tool to stratify high risk patients undergoing elective ACDF, as increasing mFI-5 scores showed significantly higher rates of all adverse outcomes accounted for in this study, except for deep incisional SSI, wo... | 4/15/2024 | |
| Weaning buprenorphine in pregnant patientssupsup | CONCLUSION: Despite counseling to stay on buprenorphine, there are patients who desire to wean. The NOWS rate in the weaned cohort was significantly lower than the controls with no observed increase in maternal or neonatal morbidity. There were no maternal overdoses or deaths during the pregnancy. L... | 4/14/2024 | |
| Assessment of Variability in Free Flap Color Match to Facial Skin by Donor Site and Race | CONCLUSION: Patients with decreased skin pigmentation who are undergoing head and neck MFTT may experience worse color discrepancy between cervicofacial skin and the transferred skin paddle than those with more pigmented skin. Portable colorimetry may identify patients who could benefit from interve... | 4/8/2024 | |
| Pathogenesis and management of diabetic gastroparesis An updated clinically oriented review | CONCLUSION: This review offers a thorough understanding of pathogenesis, diagnosis, and management of diabetic gastroparesis, underlining evolving approaches for clinicians. A multidisciplinary approach is crucial to address both the physical and mental health aspects of diabetes and its complicatio... | 4/5/2024 | |
| COVID-19 Vaccination in Patients with Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to COVID-19 a USIDNET Report | CONCLUSION: Vaccination for COVID-19 in the IEI population appears safe and attenuates COVID-19 severity. | 4/5/2024 | |
| SAEM systematic online academic resource SOAR review Gastrointestinal illnesses | CONCLUSIONS: This iteration of the SOAR review resulted in the highest number of high-quality resources compared to other SOAR reviews, with 21% of resources thus far scoring ≥ 16. A final list of high-quality resources can guide trainees, educator recommendations, and FOAM authors. | 3/25/2024 | |
| Expanding Understanding of Electrocochleography in Cochlear Implantation Auditory Neuropathy Spectrum Disorder With Normal Pure Tone Average | CONCLUSIONS: To our knowledge, this is the first reported case of CI in an ear with normal PTA. Given that nearly all presently available ECoG data comes from patients with greater degrees of hearing loss, this unique case adds to our understanding of hearing preservation in CI. | 3/22/2024 | |
| The Impact of Patient Characteristics on Outcomes of Surgically Managed Vertebral Osteomyelitis in the United States Insights from a National Database Study | This study was conducted to assess the patient characteristics, types of treatment, and outcomes of patients who are surgically treated for vertebral osteomyelitis (VO) in the United States. VO can be treated with or without surgical intervention. Surgically treated cases of VO are associated with s... | 3/20/2024 | |
| Dual Layer vs Single Layer Woven EndoBridge Device in the Treatment of Intracranial Aneurysms A Propensity Score-Matched Analysis | CONCLUSION: The WEB SL and DL devices demonstrated similar performances in immediate occlusion rates and retreatment requirements for intracranial aneurysms. The SL device showed a higher rate of complete occlusion at the final follow-up. | 3/14/2024 | |
| Antiviral drugs prolong survival in murine recessive dystrophic epidermolysis bullosa | Recessive dystrophic epidermolysis bullosa (RDEB) is a rare inherited skin disease characterized by defects in type VII collagen leading to a range of fibrotic pathologies resulting from skin fragility, aberrant wound healing, and altered dermal fibroblast physiology. Using a novel in vitro model of... | 3/11/2024 | |
| Creating a Tailored Info App to Promote Self-Management Skills in Persons with Chronic Health Conditions Development Strategies and User Experience | Persons with chronic health conditions, such as heart disease, diabetes, hypertension, and others, often experience self-management problems that are not disease specific. These include disrupted sleep, pain, memory issues, and challenges in working with healthcare providers. These patients may bene... | 3/5/2024 | |
| Long-term Airway Outcomes and Interventions in Children With Oesophageal Atresia With Tracheoesophageal Fistula A 20-year Single Centre Observational Study | CONCLUSIONS: Long-term airway pathologies are common in children with OA/TOF. Many of these are remediable with surgical intervention. Clinicians should be cognisant of this and refer to Airway Services appropriately. | 3/1/2024 | |
| Understanding Patient Utilization Patterns of Cochlear Implant Processors | CONCLUSION: Patients who have 2 CI external processors identify this as being very important to them and experience significantly less time without access to sound due to lack of a functioning processor. As institutional contracts often dictate whether a patient will receive 1 or 2 sound processors ... | 2/22/2024 | |
| Sleep Attributes Influencing Cardiovascular Morbidity Among Young Adults Pursuing Professional Courses in Dehradun, India A Cross-Sectional Study | Cardiovascular diseases (CVDs) are evolving as a cause of mortality and morbidity among young adults. Young adults, particularly those pursuing professional courses in colleges, face unique challenges that may influence their risk of developing CVD. Despite screening guidelines, CVD risk factors oft... | 2/21/2024 | |
| Buprenorphine Induction Using Microdosing for the Management of Opioid Use Disorder in Pregnancy | Background Conventional buprenorphine inductions require patients to abstain from full agonist opioids until they experience mild-to-moderate opioid withdrawal. We described a successful buprenorphine induction case in a pregnant patient using microdosing, which avoided withdrawal symptoms. Case Pre... | 2/19/2024 | |
| Safety and Efficacy of Outpatient Anterior Cervical Disk Replacement ACDR in an Ambulatory Surgery Center Versus Hospital Setting A 2-year Retrospective Analysis | CONCLUSIONS: Our 2-year results demonstrate that ACDRs performed in ASCs may offer the advantages of reduced operative time and blood loss without an increased risk of postoperative complications. | 2/17/2024 | |
| Are Patients With Segmental Cervical Kyphosis Appropriate Candidates for Cervical Disc Arthroplasty CDA A Clinical and Radiographic Analysis Compared to Anterior Cervical Discectomy and Fusion ACDF | CONCLUSION: CDA was superior to ACDF in regards to NDI scores following index procedure in patients with preoperative segmental cervical kyphosis. Those in the CDA cohort had similar complication rates, revision rates and radiographic outcomes as those who underwent ACDF. | 2/15/2024 | |
| Salvage Microsurgery Following Failed Primary Radiosurgery in Sporadic Vestibular Schwannoma | CONCLUSIONS: In this cohort study, more than half of patients who received salvage microsurgery following primary SRS/FSRT underwent less than GTR or experienced some degree of facial paresis long term. These data suggest that the cumulative risk of developing facial paresis following primary SRS/FS... | 2/15/2024 | |
| Sarcopenia versus clinical frailty scale in predicting the risk of postoperative mortality after emergency laparotomy a retrospective cohort study | CONCLUSIONS: Sarcopenia is a stronger predictor of postoperative mortality compared with CFS in patients undergoing emergency laparotomy. It cancels out the predictive value of clinical frailty scale in multivariable analyses; hence among the two variables, sarcopenia deserves to be included in preo... | 2/14/2024 | |
| Validation of a noninvasive cardiac output monitor in maternal cardiac disease comparison of NICOM and transthoracic echocardiogram | CONCLUSION: The NICOM device consistently overestimated cardiac output when compared with 2-dimensional transthoracic echocardiography at all timepoints in the control group and in the first trimester and postpartum period for the cardiovascular disease group. The physiological changes of pregnancy,... | 2/11/2024 | |
| Patient activation and medication adherence in adults | CONCLUSION: Evaluating patient activation at baseline may predict those more likely to be medication adherent in patients with low HL. | 2/6/2024 | |
| Lipedematous Scalp Occurring in Two Female Siblings Further Evidence for a Genetic Role | CONCLUSION: We present an unusual case of LS in a pair of female siblings, adding to the limited existing evidence that there may be a genetic role in the pathogenesis of LS. Furthermore, both siblings in this case had psychiatric co-morbidities and were taking psychiatric medication, which have not... | 2/6/2024 | |
| Randomized Trial of Augmented Pelvic Fixation in Patients Undergoing Thoracolumbar Fusion for Adult Spine Deformity Initial Results from a Multicenter Randomized Trial | CONCLUSIONS: SI joint pain is common in patients with adult spinal deformity who are candidates for multilevel spine fusion surgery. Concurrent placement of TTI parallel to S2AI screws during multilevel spine fusion surgery is feasible and safe. Further follow-up will help to determine the clinical ... | 2/4/2024 | |
| Impact of adrenal surgeon volume on outcome analysis of 4464 operations from the United Kingdom Registry of Endocrine and Thyroid Surgery UKRETS | CONCLUSION: Increasing surgical volume is associated with shorter hospital stay and fewer complications. This analysis supports the case for centralization of surgery for adrenal cancer and bilateral tumours to higher-volume surgeons performing a minimum of 12 operations per year. | 2/2/2024 | |
| Assessment of hemodynamic dysfunction in septic newborns by functional echocardiography a systematic review | CONCLUSION: Our review confirms that septic neonates show significant hemodynamic changes that can be identified using NPE. These findings underscore the need for wider NPE use to tailor hemodynamics-based strategies within this population. | 1/20/2024 | |
| The impact of postoperative aspirin in patients undergoing Woven EndoBridge a multicenter, institutional, propensity score-matched analysis | CONCLUSIONS: Aspirin use post-WEB treatment may lead to better functional outcomes and lower mortality but with higher retreatment rates. These insights are crucial for postoperative management after WEB procedures, but further studies are necessary for validation. | 1/18/2024 | |
| Flexible, scalable, high channel count stereo-electrode for recording in the human brain | Over the past decade, stereotactically placed electrodes have become the gold standard for deep brain recording and stimulation for a wide variety of neurological and psychiatric diseases. Current electrodes, however, are limited in their spatial resolution and ability to record from small populatio... | 1/17/2024 | |
| Comparing outcomes between anterior cervical disc replacement ACDR and minimally invasive posterior cervical foraminotomy MI-PCF in the treatment of cervical radiculopathy | CONCLUSION: Our results suggest that ACDR offer clinically relevant advantages over MI-PCF in terms of long-term revision rates despite an increased approach-related risk of transient postoperative dysphagia. Additionally, patients in the ACDR cohort achieved greater mean improvements in NDI scores ... | 1/7/2024 | |
| Decreased erythrocyte aggregation in Glenn and Fontan univentricular circulation as a rheologic disease model | CONCLUSIONS: Hematocrit corrected blood viscosity is lower in SVHD vs. healthy due to decreased RBC aggregation and higher RBC deformability, a viscous adaptation of blood in patients whose cardiac output is dependent on minimizing viscous power loss. | 1/4/2024 | |
| Five historical innovations that have shaped modern cardiothoracic surgery | Throughout history, many innovations have contributed to the development of modern cardiothoracic surgery, improving patient outcomes and expanding the range of treatment options available to patients. This article explores five key historical innovations that have shaped modern cardiothoracic surge... | 12/27/2023 | |
| Five historical innovations that have shaped modern urological surgery | Throughout history, many innovations have contributed to the development of modern urological surgery, improving patient outcomes and expanding the range of treatment options available to patients. This article explores five key historical innovations that have shaped modern urological surgery: Exte... | 12/27/2023 | |
| Provision of acute oncology services in the UK data from the Society for Acute Medicine Benchmarking Audit 2022 SAMBA22 | Acute oncology services (AOS) manage acute cancer-related presentations alongside acute medical teams. This study assessed AOS provision against national peer review measures and the burden of acute cancer-related admissions. The 2022 Society for Acute Medicine Benchmarking Audit surveyed UK hospita... | 12/8/2023 | |
| Inhibition of Neurogenic Inflammatory Pathways Associated with the Reduction in Discogenic Back Pain | CONCLUSIONS: Patients taking CGRP inhibitors for chronic migraines with comorbid degenerative spinal conditions experienced significant off-target reduction of back/neck pain. | 12/5/2023 | |
| Low referral rate of overweightobese patients with hidradenitis suppurativa to weight-management services a missed opportunity | Hidradenitis suppurativa (HS) is associated with obesity and other cardiovascular risk factors. Referral of overweight/obese patients with HS to weight-management (WM) services is advised as this may help reduce HS disease severity and cardiovascular risk. A retrospective observational study of 50 p... | 12/1/2023 | |
| Association of Elevated Serum Aldosterone Concentrations in Pregnancy with Hypertension | Emerging evidence indicates a previously unrecognized, clinically relevant spectrum of abnormal aldosterone secretion associated with hypertension severity. It is not known whether excess aldosterone secretion contributes to hypertension during pregnancy. We quantified aldosterone concentrations and... | 11/25/2023 | |
| Real-world treatment preferences among health care providers in the United States in selecting disease modifying therapies for patients with multiple sclerosis a discrete choice experiment | CONCLUSION: In the direct assessment, clinical attributes were chosen as the most important treatment attributes by HCPs. However, in the DCE, derived treatment decisions rated logistical attributes as also being as important in treatment choice. | 11/7/2023 | |
| Unique Cardiopulmonary Interactions in Congenital Diaphragmatic Hernia Physiology and Therapeutic Implications | Congenital diaphragmatic hernia (CDH) results in abdominal contents entering the thoracic cavity, affecting both cardiac and pulmonary development. Maldevelopment of the pulmonary vasculature occurs within both the ipsilateral lung and the contralateral lung. The resultant bilateral pulmonary hypopl... | 10/31/2023 | |
| Rationale for the Development of a Novel Clinical Grading Scale for Postoperative Facial Nerve Function Results of a Multidisciplinary International Working Group | CONCLUSIONS: Members were invited to submit proposed grading systems in alignment with the objectives of the working group for subsequent validation. From these data, we plan to develop a simple, clinically anchored, and reproducible staging system with regional scoring for assessing early postopera... | 10/24/2023 | |
| Prophylactic uterine artery embolization in first-trimester cervical pregnancy termination with placenta accreta A case report | The current standard treatment for placenta accreta is a hysterectomy, which carries a significant risk of hemorrhage. Although prophylactic uterine artery embolization (UAE) is established as an effective means of minimizing perioperative bleeding, there are few reports of its use early in pregnanc... | 10/23/2023 | |
| Stent-assisted Woven EndoBridge device for the treatment of intracranial aneurysms an international multicenter study | CONCLUSIONS: This study demonstrates that there is no difference in the degree of aneurysm occlusion between the two groups; however, complications were more frequent in the stent group. In addition, a wider aneurysm neck predisposes to stent assistance in WEB-treated aneurysms. | 10/20/2023 | |
| The age of computational cardiology and future of long-term ablation target prediction for ventricular tachycardia | Ventricular arrhythmias, particularly ventricular tachycardia, are ubiquitously linked to 300,000 deaths annually. However, the current interventional procedure-the cardiac ablation-predict only short-term responses to treatment as the heart constantly remodels itself post-arrhythmia. To assist in t... | 10/11/2023 | |
| Should patient eligibility criteria for cervical disc arthroplasty CDA be expanded A retrospective cohort analysis of relatively contraindicated patients undergoing CDA | CONCLUSIONS: Our study found no significant differences in clinical and functional outcomes between patients undergoing 1- and 2-level CDA with relative contraindications versus typical patients. These findings suggest that patient eligibility criteria for CDA may warrant expansion. However, future ... | 9/29/2023 | |
| Cardiac amyloidosis evolving pathogenesis, multimodal diagnostics, and principles of treatment | Amyloidosis is a protein deposition disorder in which insoluble fibril structures accumulate in the bodily tissues damaging the organ function. Cardiac amyloidosis is a severe but under-reported medical condition characterized by the accumulation of amyloid in the extracellular area of the myocardiu... | 9/18/2023 | |
| Myopathies of endocrine origin A review for physicians | Myopathies are a common manifestation of endocrine disorders. Endocrine myopathies are often overlooked while considering differential diagnoses in patients with musculoskeletal symptoms. The hindrance to mobility and the musculoskeletal discomfort owing to these myopathies are important causes of d... | 9/17/2023 | |
| Epidemiological Correlates of Substance Abuse Among In-Facility Clients of De-addiction and Rehabilitation Centres of District Dehradun A Cross-Sectional Study | Background The increasing production, distribution, promotion, and availability of substances contemporaneous with the changing values of society have resulted in rising substance abuse as an emerging public health concern in India. A prevalence of 32-37% has been reported for substance abuse in var... | 9/4/2023 | |
| Peculiar Neurological Examination Secondary to Persistent Primitive Hypoglossal Artery | A persistent primitive hypoglossal artery (PPHA) is an anatomical variant resulting in persistent carotid-vertebrobasilar anastomoses. This variant arises from the distal cervical segment of the internal carotid artery (ICA) between C1 and C3 and passes through an enlarged hypoglossal canal to join ... | 8/23/2023 | |
| The 5-Factor Modified Frailty Index is Associated With Increased Risk of Reoperations and Adjacent Level Disease Following Single-Level Transforaminal Lumbar Interbody Fusion | CONCLUSION: High levels of frailty were predictive of related readmissions, reoperations, any complications, and ASD in older adult patients undergoing single-level TLIF. | 8/19/2023 | |
| The Natural History of Observed SDHx -Related Head and Neck Paragangliomas Using Three-Dimensional Volumetric Tumor Analysis | CONCLUSIONS: Over intermediate-term follow-up, observation of treatment-naive SDHx -related HNPGLs did not result in new cranial neuropathy. Although indefinite observation is only appropriate for select cases, these data support an interval of observation to characterize growth rate in asymptomatic... | 8/17/2023 | |
| A Comprehensive Review on Neuroendocrine Neoplasms Presentation, Pathophysiology and Management | Neuroendocrine neoplasms (NENs) are a group of heterogeneous tumors with neuroendocrine differentiation that can arise from any organ. They account for 2% of all malignancies in the United States. A significant proportion of NEN patients experience endocrine imbalances consequent to increased amine ... | 8/12/2023 | |
| Good outcome of surgical treatment for contaminated penile wound due to a fall from stairs a case report | CONCLUSIONS: Penile trauma is severely under-reported due to the stigma associated with it. Early diagnosis and prompt management are imperative to limit complications. A detailed history helps to evaluate the exact cause and check out possibilities of sexual assault. Appropriate management in tande... | 7/26/2023 | |
| Effect of the Law Enforcement Duty Belt on Muscle Activation during Hip Hinging Movements in Young, Healthy Adults | Sixty percent of all law enforcement officers (LEOs) experience low back pain (LBP), with the LEO duty belt (LEO(DB)) commonly reported to be a contributing factor. The primary purpose of the study was to investigate the LEODB's effect on muscular activity and compare it to a tactical vest, which is... | 7/25/2023 | |
| Modulated Fibrosis and Mechanosensing of Fibroblasts by SB525334 in Pediatric Subglottic Stenosis | CONCLUSION: We demonstrate that distinct fibroblast phenotypes from diseased and healthy regions of pediatric SGS patients respond differently to TGF-β1 stimulation, and SB525334 has the superior potential for subglottic stenosis treatment by simultaneously modulating TGF-β and Hippo signaling pathw... | 7/17/2023 | |
| Common law enforcement load carriage systems have limited acute effects on postural stability and muscle activity | Law enforcement officers are inherently at a high risk of injury and the loads they must carry during their occupational duties further increase their injury risk. It is unknown how different methods of carrying a law enforcement officer's load influence factors related to injury risk. This study as... | 7/12/2023 | |
| Management of Pediatric Persistent Asymptomatic Cervical Lymphadenopathy | CONCLUSION: The majority of pediatric PACL is benign and does not require an excisional biopsy to rule out lymphoma. Serial clinical follow-up with neck ultrasound can be used to safely monitor patients. | 7/7/2023 | |
| Dynamics of pulmonary hypertension severity in the first 48h in neonates with prenatally diagnosed congenital diaphragmatic hernia | INTRODUCTION: Pulmonary hypertension (PH) is one of the major contributing factors to the high morbidity and mortality in neonates with congenital diaphragmatic hernia (CDH). The severity and duration of postnatal PH are an established risk factor for patient outcome; however, the early postnatal dy... | 6/21/2023 | |
| Pembrolizumab-associated chronic rhinosinusitis A new endotype and management considerations | Patients treated with pembrolizumab experience an increase in paranasal sinus inflammation Use of topical triamcinolone in carboxymethylcellulose is a treatment option for such patients. | 6/15/2023 | |
| Gastrointestinal haemorrhage in extracorporeal membrane oxygenation insights from the national inpatient sample | CONCLUSIONS: Gastrointestinal haemorrhage during ECMO hospitalisations occurred in small but significantly increasing proportions. The inpatient mortality rate and costs associated with GIH were substantial and increased significantly during the study period. | 6/14/2023 | |
| VITRECTOMY FOR VITREOUS HEMORRHAGE ASSOCIATED WITH RETINAL VEIN OCCLUSION Visual Outcomes, Prognostic Factors, and Sequelae | CONCLUSION: Pars plana vitrectomy is effective for VH associated with retinal vein occlusion, regardless of the duration of hemorrhage. However, pre-existing risk factors and postoperative sequelae may limit visual recovery. | 6/9/2023 | |
| Persistent hiccups following thalamic hemorrhage A case report | Persistent hiccups (lasting more than 48 hours) can cause physical and emotional distress. They can result in dehydration, exhaustion, malnutrition, insomnia, wound dehiscence, ventilatory desynchronization, and hemodynamic changes. Hiccups are thought to be due to a complex reflex arc involving per... | 6/5/2023 | |
| Deep net detection and onset prediction of electrographic seizure patterns in responsive neurostimulation | OBJECTIVE: Managing the progress of drug-resistant epilepsy patients implanted with the Responsive Neurostimulation (RNS) System requires the manual evaluation of hundreds of hours of intracranial recordings. The generation of these large amounts of data and the scarcity of experts' time for evaluat... | 5/27/2023 | |
| Artificial intelligence in healthcare and education | Artificial intelligence (AI) is rapidly transforming the healthcare and medical and dental education sectors. With advancements in AI technology and its integration into routine tasks, the field of healthcare and education is rapidly evolving. This article aims to provide an in-depth analysis of the... | 5/26/2023 | |
| Comparing clinical and radiological outcomes between single-level OLIF and XLIF A systematic review and meta-analysis | CONCLUSIONS: This meta-analysis demonstrates similar clinical and radiological outcomes between single-level OLIF and XLIF from L1 to L5. XLIF had significantly higher rates of neuropraxia, whereas OLIF had greater rates of vascular injury. | 5/26/2023 | |
| Long-Term Follow-Up of Cerebral Aneurysms Completely Occluded at 6 Months After Intervention with the Woven EndoBridge WEB Device a Retrospective Multicenter Observational Study | The Woven EndoBridge (WEB) device has been widely used to treat intracranial wide neck bifurcation aneurysms. Initial studies have demonstrated that approximately 90% of patients have same or improved long-term aneurysm occlusion after the initial 6-month follow up. The aim of this study is to asses... | 5/10/2023 | |
| Diabetic neuropathy Pathogenesis and evolving principles of management | The global rise of prediabetes and diabetes has spawned an epidemic of complications associated with these conditions. Neuropathy is the most common consequence, with distal symmetric polyneuropathy (DSP) being the most prevalent. Diabetic neuropathy (DN) is a debilitating consequence of diabetes me... | 5/10/2023 | |
| Electrochemical Lipolysis Induces Adipocyte Death and Fat Necrosis In Vivo Pilot Study in Pigs | CONCLUSIONS: In vivo ECLL induces fat necrosis in pigs. Further studies are needed to evaluate volumetric fat reduction. | 5/10/2023 | |
| Cognitive function and impact on driving after SARS-COV-2 infection in a man with long-standing HIV infection a case report | A substantial number of individuals who experience COVID-19 infection experience prolonged physical and mental symptoms after resolution of their initial infection, and among them, many individuals experience cognitive difficulties including memory lapses and executive function difficulties, often r... | 5/9/2023 | |
| The Relationship Between an Individuals Birthday and Admission for Traumatic Injury | BACKGROUND: Birthdays provide an opportunity to celebrate; however, they can also be associated with various adverse medical events. This is the first study to examine the association between birthdays and in-hospital trauma team evaluation. | 5/6/2023 | |
| The Impact of Relocating a Trauma Center Retrospective Observations on Payer Demographics and Cost-Analysis | BACKGROUND: Standardization of trauma centers improves quality of care, yet that comes with financial challenges. The decision to designate a trauma center typically focuses on access, quality of care, and the needs of the local community, but less often considers the financial viability of the trau... | 5/4/2023 | |
| Long-term, in vivo therapeutic effects of a single dose of miR-145 micelles for atherosclerosis | Atherosclerosis is a chronic inflammatory disease that is characterized by the build-up of lipid-rich plaques in the arterial walls. The standard treatment for patients with atherosclerosis is statin therapy aimed to lower serum lipid levels. Despite its widespread use, many patients taking statins ... | 5/1/2023 | |
| The Discrepancy and Agreement between Patient-Reported Percentage Pain Reduction and Calculated Percentage Pain Reduction in Chronic Pain Patients | Two derivatives of the numeric rating scale (NRS) and visual analog scale (VAS), namely patient-reported percentage pain reduction (PRPPR) and calculated percentage pain reduction (CPPR), are commonly used when evaluating pain reduction. A small number of studies have attempted to assess the agreeme... | 4/24/2023 | |
| Environmental correlates of infectious diseases in South-East Asia A perspective on the missed link | •Climate change, essentially due to global warming, the plundering of the earth's ecosystem.•Changing climatic circumstances may affect species' range and density.•Infectious disease can be seen as an outcome derived from multi-factorial correlates.•"One health" needs more attention, specially in re... | 4/24/2023 | |
| A mobile app for chronic disease self-management for individuals with low health literacy A multisite randomized controlled clinical trial | CONCLUSIONS: The mobile app was effective in increasing participants' levels of several psychosocial variables, but reading difficulty level was not significantly related to outcomes.Registered at clinicaltrials.gov NCT02922439. | 4/17/2023 | |
| TFCP2 is a transcriptional regulator of heparan sulfate assembly and melanoma cell growth | Heparan sulfate (HS) is a long, linear polysaccharide that is ubiquitously expressed in all animal cells and plays a key role in many cellular processes, including cell signaling and development. Dysregulation of HS assembly has been implicated in pathophysiological conditions, such as tumorigenesis... | 4/15/2023 | |
| Gene Editing as the Future of Cardiac Amyloidosis Therapeutics | Cardiac Amyloidosis (CA) is a manifestation of a systemic disorder resulting from the deposition of transthyretin (TTR) in the myocardium. This leads to a myriad of manifestations ranging from conduction defects to heart failure. Previously CA was considered a rare disease, but recent advances in di... | 4/14/2023 | |
| Role of microRNAs in Congenital Diaphragmatic Hernia-Associated Pulmonary Hypertension | Epigenetic regulators such as microRNAs (miRNAs) have a key role in modulating several gene expression pathways and have a role both in lung development and function. One of the main pathogenetic determinants in patients with congenital diaphragmatic hernia (CDH) is pulmonary hypertension (PH), whic... | 4/13/2023 | |
| Through a New Lens Skin-Grafted Free Flaps and Objective Facial Skin Color Matching | Background: Head and neck ablative surgery can impose aesthetic disfigurement, particularly when severe color mismatch exists between native and reconstructed facial skin. To date, the accuracy, objectivity, and modifiability of facial skin color matching remains poorly understood. Objective: To mea... | 4/10/2023 | |
| Epidemiology and Risk Factors for Development of Sporadic Vestibular Schwannoma | Vestibular schwannomas (VSs) are benign, slow-growing tumors of the eighth cranial nerve. Sporadic unilateral VSs constitute approximately 95% of all newly diagnosed tumors. There is little known about risk factors for developing sporadic unilateral VS. Potential risk factors that have been reported... | 4/5/2023 | |
| Heart of the Matter Cardiac Dysfunction in Congenital Diaphragmatic Hernia | Despite advances in caring for neonates with congenital diaphragmatic hernia (CDH), mortality and morbidity continues to be high. Additionally, the pathophysiology of cardiac dysfunction in this condition is poorly understood. Postnatal cardiac dysfunction in neonates with CDH may be multifactorial ... | 4/3/2023 | |
| Type 1 Diabetes Mellitus and Autoimmune Diseases A Critical Review of the Association and the Application of Personalized Medicine | Type 1 Diabetes Mellitus (T1DM) is a common hyperglycemic disease characterized by the autoimmune destruction of insulin-producing beta cells of the pancreas. Various attempts have been made to understand the complex interplay of genetic and environmental factors which lead to the development of the... | 3/29/2023 | |
| Approach to Cochlear Implantation in Patients With Ventriculoperitoneal Shunts | CONCLUSION: CI can be performed at low risk, either contralateral or ipsilateral, to a VP shunt, and does not mandate shunt revision in most cases. Additional considerations regarding CI receiver-stimulator placement are necessary with programmable shunts to mitigate device interaction. Preoperative... | 3/20/2023 | |
| Ductus arteriosus flow predicts outcome in neonates with congenital diaphragmatic hernia | CONCLUSIONS: A VTI ratio <1.0 is a valuable threshold to identify high-risk CDH neonates. For improved risk stratification, other parameters-for example, left ventricular cardiac dysfunction-should be combined with DA flow assessment. | 3/15/2023 | |
| Phase III, two arm, multi-centre, open label, parallel-group randomised designed clinical investigation of the use of a personalised early warning decision support system to predict and prevent acute exacerbations of chronic obstructive pulmonary disease Predict amp; Prevent AECOPD - study protocol | INTRODUCTION: With 65 million cases globally, chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death and imposes a heavy burden on patients' lives and healthcare resources worldwide. Around half of all patients with COPD have frequent (≥2 per year) acute exacerbations of C... | 3/13/2023 | |
| Precision Medicine and the future of Cardiovascular Diseases A Clinically Oriented Comprehensive Review | Cardiac diseases form the lion's share of the global disease burden, owing to the paradigm shift to non-infectious diseases from infectious ones. The prevalence of CVDs has nearly doubled, increasing from 271 million in 1990 to 523 million in 2019. Additionally, the global trend for the years lived ... | 3/11/2023 | |
| Identification and characterization of new candidates for abdominal aortic aneurysm screening in patients outside of current accepted guidelines | CONCLUSIONS: Our analysis suggests male ever-smokers aged 45 to 65, male never-smokers aged 65 to 75, male never-smokers aged greater than 75, and female ever-smokers aged 65 or greater have a more than 1% prevalence of AAA and, therefore, may benefit from screening. Outcomes were significantly wors... | 3/9/2023 | |
| Revisiting Migraine The Evolving Pathophysiology and the Expanding Management Armamentarium | Migraine affects about one billion people worldwide yearly and is one of the most common neurologic illnesses, with a high prevalence and morbidity, particularly among young adults and females. Migraine is associated with many comorbidities, including stress, sleep difficulties, and suicidal ideatio... | 3/7/2023 | |
| Congenital nasal pyriform aperture stenosis; our experience of 34 cases | CONCLUSION: These results suggest that a pyriform aperture of less than 6 mm requires surgical intervention. Associated birth anomalies add additional management considerations but in this cohort were not associated with increased need for surgery. A potential association between CNPAS and low socio... | 3/4/2023 | |
| Extracellular Vesicles as Regulators of the Extracellular Matrix | Extracellular vesicles (EVs) are small membrane-bound vesicles secreted into the extracellular space by all cell types. EVs transfer their cargo which includes nucleic acids, proteins, and lipids to facilitate cell-to-cell communication. As EVs are released and move from parent to recipient cell, EV... | 2/25/2023 | |
| The Impact of Prematurity at Birth on Short-Term Postoperative Outcomes Following Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis | Prematurity is associated with surgical complications. This study sought to determine the risk of prematurity on 30-day complications, reoperations, and readmissions following ≥7-level PSF for AIS which has not been established. Utilizing the American College of Surgeons National Surgical Quality Im... | 2/11/2023 | |
| Ancillary techniques to improve dermoscopy specificity for skin cancer detection | Although the use of dermoscopy has markedly improved both the sensitivity and specificity for skin cancer detection, there is still opportunity for improvement. Ancillary techniques provide additional ways to assess a lesion with the aim of improving our diagnostic ability with little extra cost. Us... | 2/10/2023 | |
| IL-13-associated epithelial remodeling correlates with clinical severity in nasal polyposis | CONCLUSIONS: These results demonstrate that cell-type alterations and prostaglandin E2 stimulation are key components of IL-13-induced epithelial remodeling in nasal polyposis, whereas IL-17 signaling is more prominent in CRS without polyps, and that clinical severity correlates with the degree of I... | 2/3/2023 | |
| Early nitric oxide is not associated with improved outcomes in congenital diaphragmatic hernia | CONCLUSIONS: Use of iNO in the first 3 days of life prior to ECLS was not associated with a reduction in mortality or ECLS use in either the regression models or the subgroup analyses. The widespread use of iNO in this vulnerable population requires reconsideration. | 2/1/2023 | |
| Safety of Continuing Anticoagulation Prior to Cardiac Catheterization in Pediatric Patients A Los Angeles Center Experience | This is the first report specifically describing outcomes of pediatric patients who underwent cardiac catheterization while on uninterrupted anticoagulation. One hundred forty-four cardiac catheterizations were identified that met inclusion criteria at our institution from 11/2014 to 10/2019. The me... | 2/1/2023 | |
| Somatic mutation but not aneuploidy differentiates lung cancer in never-smokers and smokers | Lung cancer in never-smokers disproportionately affects older women. To understand the mutational landscape of this cohort, we performed detailed genome characterization of 73 lung adenocarcinomas from participants of the Women’s Health Initiative (WHI). We find enrichment of EGFR mutations in nev... | 1/30/2023 | |
| Diagnosis, Prognosticators, and Management of Acute Invasive Fungal Rhinosinusitis Multidisciplinary Consensus Statement and Evidence-Based Review with Recommendations | CONCLUSION: Based on the currently available evidence, judicious utilization of a combination of history and physical examination, laboratory and histopathologic techniques, and endoscopy provide the cornerstone for accurate diagnosis of AIFS. In addition, AIFS is optimally managed by a multidiscipl... | 1/21/2023 | |
| Electromechanical Cornea Reshaping for Refractive Vision Therapy | The corneal stroma consists of orthogonally stacked collagen-fibril lamellae that determine the shape of the cornea and provide most of the refractive power of the eye. We have applied electromechanical reshaping (EMR), an electrochemical platform for remodeling cartilage and other semirigid tissues... | 1/12/2023 | |
| Opportunities for implementing a patient-initiated follow-up pathway for patients with psoriasis completing phototherapy | We performed a retrospective case analysis to identify opportunities to introduce a patient-initiated follow-up (PIFU) pathway for patients with psoriasis completing narrowband ultraviolet B phototherapy at our centre. In total, 42 patients completed phototherapy between January 2016 and August 2018... | 1/11/2023 | |
| Acute Hepatitis of Unknown Origin in Pediatric Age Group Recent Outbreaks and Approach to Management | Acute hepatitis has always been a public health concern, but the recent clustering of cases in various parts of the world has drawn some special attention. The sudden rise in cases has mainly been among the pediatric population of around 35 countries around the world, including developed countries s... | 1/8/2023 | |
| Hypertension the Missed Modifiable Risk Factor for Diabetic Neuropathy a Systematic Review | Diabetes and hypertension stand as the major non-infectious diseases affecting 34.2 million and 1.28 billion people respectively. The literature on the impact of diabetes on hypertension and vice versa is evolving. The major objectives of this review were to compile the evolving literature establish... | 12/30/2022 | |
| Factors Influencing Motivation to Perform Mental and Physical Tasks During the Initial Lockdown Period of the COVID-19 | Drastic changes to lifestyles have occurred during the COVID-19 pandemic. An unintended consequence of stay at home orders is increased isolation and less social interaction for many people. For overall wellbeing it is important to stay both physically and mentally active; however, for many individu... | 12/30/2022 | |
| Disease recidivism after subtotal petrosectomy and ear canal closure | CONCLUSIONS: Recidivistic disease often remains clinically silent for extended periods of time after STP. Planned follow-up - with imaging or second look surgery - to facilitate early detection should be considered. Undetected disease recurrence or development may result in morbidity in a proportion... | 12/29/2022 | |
| Isolated aortic arch anomalies are associated with defect severity and outcome in patients with congenital diaphragmatic hernia | CONCLUSIONS: IAAA in CDH are associated with increased mortality. This often simply reflects severity of the defect and thoracic anatomic derangement, as opposed to unique aortic pathology, given few CDH + IAAA patients undergo aortic intervention. | 12/29/2022 | |
| The 5-factor modified Frailty Index mFI-5 predicts adverse outcomes after elective Anterior Lumbar Interbody Fusion ALIF | CONCLUSIONS: The mFI-5 is an independent predictor for 30-day postoperative complications, readmissions, UTI, pneumonia, and unplanned intubations following elective ALIF surgery in adults over the age of 50. | 12/29/2022 | |
| Patient-Perceived Satisfaction and Knowledge Uptake in a Combined Cardio-Obstetrics Clinic | Heart disease is the leading cause of pregnancy-related mortality in the United States and has led to the development of combined cardio-obstetrics (COB) clinics as a model for prenatal care. In other areas of medicine, these types of collaborative care models have shown improvement in morbidity, mo... | 12/22/2022 | |
| Cochlear promontory anatomy relevant to development of subendosteal and transpromontory electrodes using 192-section ultra-high resolution temporal bone CT imaging | CONCLUSIONS: Cochlear promontory thickness can vary by almost 1.5 mm across patients and is significantly associated with patient sex, body mass index, and comorbid osteopenia/osteoporosis. Subendosteal and transpromontory electrode placement techniques must account for this degree of variability. | 12/22/2022 | |
| Hemichorea-Hemiballism as a Delayed Manifestation of Hyperglycemia A Case Report | Hemichorea is characterized by involuntary, continuous, non-patterned movements on one side of the body. While it is most commonly caused by strokes, it can also be caused by metabolic derangements such as hyperglycemia. We present two patients who developed hemichorea in the setting of hyperglycemi... | 12/19/2022 | |
| In vivo electrochemical lipolysis of fat in a Yucatan pig model A proof of concept study | CONCLUSIONS: ECLL results in selective damage and long-lasting changes to the adipose layer in vivo. These changes are dose-dependent, thus allowing for more precise contouring of target areas. P-ECLL has greater efficiency and control of total charge transfer compared to V-ECLL, suggesting that a l... | 12/13/2022 | |
| Artificial Intelligence in Pediatric Cardiology A Scoping Review | The evolution of AI and data science has aided in mechanizing several aspects of medical care requiring critical thinking: diagnosis, risk stratification, and management, thus mitigating the burden of physicians and reducing the likelihood of human error. AI modalities have expanded feet to the spec... | 12/11/2022 | |
| Factors associated with hearing outcomes after a middle fossa approach in 131 consecutive patients with vestibular schwannomas | CONCLUSIONS: The hearing preservation rates after microsurgical resection of small VSs using the middle fossa approach are high, with 78% of patients maintaining AAO-HNS class A or B hearing. Poor hearing status at baseline, longer duration of anesthesia, and large overlap between the fundus of the ... | 12/3/2022 | |
| Unsolved problems in CDH follow-up | In patients affected by CDH, survival beyond the neonatal period continues to increase thanks to technological and pharmacological improvements. Conversely, patients, families and caregivers are more and more frequently facing "new" complex late comorbidities, including chronic pulmonary and cardiac... | 11/17/2022 | |
| The Impact of Relocating a Trauma Center Observations on Patient Injury Demographics and Resident Volumes | Introduction Changing the physical zip code location of an academic trauma center may affect the distribution and surgical volume of its trauma patients. General surgical residency case log requirements may also be affected. This study describes the impact of moving a level I trauma center to a diff... | 11/16/2022 | |
| Oral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease A Randomized Controlled Trial | CONCLUSION: ENT-01 was safe and significantly improved constipation. | 11/7/2022 | |
| Knowledge, Attitude and Practices of Postpartum Females Regarding the Acceptance of Immediate Postpartum Contraception A Cross-Sectional Study From North India | The immediate postpartum period is a great time to encourage the acceptance of contraceptive methods; the time is influenced by both emotional and physical factors. At this stage, the administration of intrauterine contraceptives is relatively easier with lesser complications due to the prior obstet... | 11/7/2022 | |
| Pathogenesis and management of multiple sclerosis revisited | CONCLUSIONS: The recent past has seen staggering inclusions to the management of multiple sclerosis catalyzing a significant turnabout in our approach to diagnosis, treatment, and prognosis. Since the advent of DMTs various other oral and injectable agents have been approved. The advances in MS ther... | 10/24/2022 | |
| Diaphragmatic Hernia With Incarcerated Spleen as a Complication After Lateral Anterior Column Realignment | CONCLUSION: Iatrogenic diaphragmatic hernia with an intrathoracic spleen after direct lateral ACR is a risk spine surgeons should be aware of and address promptly. | 10/13/2022 | |
| Cochlear Implantation in Patients With Known Cognitive Impairment What Are the Benefits | CONCLUSIONS: This study demonstrates that patients with cognitive impairment before CI can experience improved hearing, no increased risk of complications, and good longevity after CI. Further prospective studies are needed to further define the utility of CI in patients with impaired cognition. | 10/6/2022 | |
| Association of Baseline Frailty Status and Age With Postoperative Complications After Cochlear Implantation A National Inpatient Sample Study | CONCLUSION: Among those evaluated, this study demonstrates that CI is a low-risk procedure in participants of all ages. Increasing frailty does not predispose to postoperative complications. However, frail patients are at additional risk for an eLOS and nonhome discharge. Short follow-up time, hospi... | 10/3/2022 | |
| A Co-Association of Streptococcus mutans and Veillonella parvuladispar in Root Caries Patients and emIn Vitroem Biofilms | Root caries in geriatric patients is a growing problem as more people are maintaining their natural teeth into advanced age. We determined the levels of various bacterial species previously implicated in root caries disease or health using quantitative real-time PCR in a pilot study of 7 patients wi... | 9/21/2022 | |
| Is There an Inherited Contribution to Risk for Sporadic Unilateral Vestibular Schwannoma Evidence of Familial Clustering | CONCLUSION: These results provide strong evidence for an inherited predisposition to sporadic, unilateral VS. This study exhibits the value of genealogical resources with linked medical data for examining hypotheses regarding inherited predisposition. The high-risk unilateral VS pedigrees identified... | 9/16/2022 | |
| Left bundle branch area pacing in patients with heart failure and right bundle branch block Results from International LBBAP Collaborative-Study Group | CONCLUSION: LBBAP is a feasible alternative to deliver CRT or physiologic ventricular pacing in patients with RBBB, HF, and LV dysfunction. | 9/13/2022 | |
| The Woven EndoBridge WEB Device for the Treatment of Intracranial Aneurysms Ten Years of Lessons Learned and Adjustments in Practice from the WorldWideWEB Consortium | Several studies have shown promising outcomes of the Woven EndoBridge (WEB) device for the treatment of wide-necked intracranial bifurcation aneurysms. This is a multicenter study attempts to explore the changes in trends and treatment outcomes over time for WEB embolization of intracranial aneurysm... | 9/6/2022 | |
| Targeting cell-matrix interface mechanobiology by integrating AFM with fluorescence microscopy | Mechanosensing at the interface of a cell and its surrounding microenvironment is an essential driving force of physiological processes. Understanding molecular activities at the cell-matrix interface has the potential to provide novel targets for improving tissue regeneration and early disease inte... | 9/2/2022 | |
| The heart in congenital diaphragmatic hernia Knowns, unknowns, and future priorities | There is growing recognition that the heart is a key contributor to the pathophysiology of congenital diaphragmatic hernia (CDH), in conjunction with developmental abnormalities of the lung and pulmonary vasculature. Investigations to date have demonstrated altered fetal cardiac morphology, notably ... | 9/2/2022 | |
| Takotsubo Cardiomyopathy and Trauma The Role of Injuries as Physical Stressors | CONCLUSIONS: TTC in traumatic injuries is common at both ends of the severity spectrum and has different sex distribution. TTC patients are predominantly females and have more commonly extremity trauma than head injury. Males are more severely injured and under mechanical ventilation. | 9/1/2022 | |
| Diagnosis amp; management of pulmonary hypertension in congenital diaphragmatic hernia | Congenital diaphragmatic hernia (CDH) contributes to neonatal morbidity and mortality worldwide. Pulmonary hypertension (PH) is a key component of CDH pathophysiology and critical consideration for management and therapeutic options. PH associated with CDH has traditionally been attributed to pulmon... | 8/22/2022 | |
| Upper body push to pull ratios in law enforcement officer recruits | CONCLUSION: Practitioners may benefit from examining eP2P and sP2P as they should not be used interchangeably. Future research should examine whether the P2P ratios are associated with injury and subsequent inability to successfully complete law enforcement training academies. | 8/21/2022 | |
| The 5-factor modified frailty index mFI-5 is predictive of 30-day postoperative complications and readmission in patients with adult spinal deformity ASD | CONCLUSION: The mFI-5 score predicted complications and postoperative events in the ASD population. The mFI-5 may effectively predict 30-day readmissions. Further research is needed to identify the benefits and predictive value of mFI-5 as a risk assessment tool. | 8/18/2022 | |
| Endocrine manifestations of chronic kidney disease and their evolving management A systematic review | CONCLUSION: Increased advertence regarding the pathology, impact, and management of these endocrine derangements can help in reducing morbidity as well as mortality in the CKD patients by allowing prompt individualized treatment. Moreover, with timely and appropriate intervention, a long-term reduct... | 8/14/2022 | |
| A Comprehensive Review of Thrombocytopenia With a Spotlight on Intensive Care Patients | Thrombocytopenia is a common entity seen in ICU patients and is associated with increased morbidity such as bleeding and transfusions, and mortality in ICU patients. Various mechanisms such as decreased platelet production, sequestration, destruction, consumption, and sometimes a combination of thes... | 8/11/2022 | |
| Tuning CobaltII Phosphine Complexes to be Axially Ambivalent | We report the isolation and characterization of a series of three cobalt(II) bis(phosphine) complexes with varying numbers of coordinated solvent ligands in the axial position. X-ray quality crystals of [Co(dppv)(2)][BF(4)](2) (1), [Co(dppv)(2)(NCCH(3))][BPh(4)](2) (2), and [Co(dppv)(2)(NCCH(3))(2)]... | 8/3/2022 | |
| Anogenital dermatology caseload analysis of new outpatient referrals at a single dermatology centre | Little is known about the volume of outpatient referrals for anogenital dermatoses received by NHS dermatology departments. We undertook a caseload analysis at our centre and found 6.0% of GP referrals to Dermatology were for anogenital dermatoses. This has important implications for training in thi... | 7/30/2022 | |
| Intraoperative confocal laser endomicroscopy prospective in vivo feasibility study of a clinical-grade system for brain tumors | CONCLUSIONS: The clinical-grade CLE system allows in vivo, intraoperative, high-resolution cellular visualization of tissue microstructure and identification of lesional tissue patterns in real time, without the need for tissue preparation. | 7/28/2022 | |
| Intrasaccular flow disruption for ruptured aneurysms an international multicenter study | CONCLUSION: There was no significant difference in both the radiologic outcomes and complications between unruptured and ruptured aneurysms. Our findings support the feasibility of treatment of ruptured aneurysms with the WEB device. | 7/22/2022 | |
| Use of Prostaglandin E1 in the Management of Congenital Diaphragmatic Hernia-A Review | Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly, whose presentation is complicated by pulmonary hypertension (PH), pulmonary hypoplasia, and myocardial dysfunction, each of which have significant impact on short-term clinical management and long-term outcomes. Despite many advance... | 7/18/2022 | |
| Therapeutic Response of miR-145 Micelles on Patient-Derived Vascular Smooth Muscle Cells | During atherosclerosis, vascular smooth muscle cells (VSMCs) undergo a phenotypic transition from a healthy contractile state into pathological phenotypes including a proliferative and migratory, synthetic phenotype and osteochondrogenic-like phenotype that exacerbate plaques. Thus, inhibiting the t... | 7/5/2022 | |
| Ipsilateral Facial Hyperhidrosis in a Patient With Squamous Cell Carcinoma of the Lung | While anhidrosis in Horner's Syndrome is a well-documented result of apical lung malignancies impinging on the sympathetic pathway traveling through the upper lobe of the lung, its opposite effect, hyperhidrosis, is a seldom reported consequence. Hyperhidrosis occurs as a result of irritation of the... | 6/15/2022 | |
| Congenital diaphragmatic hernia | Congenital diaphragmatic hernia (CDH) is a rare birth defect characterized by incomplete closure of the diaphragm and herniation of fetal abdominal organs into the chest that results in pulmonary hypoplasia, postnatal pulmonary hypertension owing to vascular remodelling and cardiac dysfunction. The ... | 6/1/2022 | |
| Enhancers regulate 3 end processing activity to control expression of alternative 3UTR isoforms | Multi-UTR genes are widely transcribed and express their alternative 3'UTR isoforms in a cell type-specific manner. As transcriptional enhancers regulate mRNA expression, we investigated if they also regulate 3'UTR isoform expression. Endogenous enhancer deletion of the multi-UTR gene PTEN did not i... | 5/17/2022 | |
| Cardiac Magnetic Resonance to Predict Coronary Artery Compression in Transcatheter Pulmonary Valve Implantation Into Conduits | CONCLUSIONS: CMR can help predict the risk for CA compression during TPVi in RV-PA conduits but cannot completely exclude CA compression. CMR may assist in patient selection and counseling families prior to TPVi, although balloon testing remains essential. | 5/5/2022 | |
| Comparing treatment outcomes of various intracranial bifurcation aneurysms locations using the Woven EndoBridge WEB device | CONCLUSION: To our knowledge, this is the most extensive study to date that compares the treatment of different intracranial bifurcation aneurysms using the WEB device. Basilar tip and ICA bifurcation aneurysms showed significantly higher rates of aneurysm occlusion than other locations. | 4/28/2022 | |
| Multicenter Study for the Treatment of Sidewall versus Bifurcation Intracranial Aneurysms with Use of Woven EndoBridge WEB | Background The Woven EndoBridge (WEB) device was explicitly designed for wide-neck intracranial bifurcation aneurysms. Small-scale reports have evaluated the off-label use of WEB devices for the treatment of sidewall aneurysms, with promising outcomes. Purpose To compare the angiographic and clinica... | 4/19/2022 | |
| Long-term Cure of Primary Hyperparathyroidism After Scan-Directed Parathyroidectomy Outcomes From A UK Endocrine Surgery Unit | CONCLUSION: Recurrence after scan-directed unilateral neck exploration occurred in 4% of patients after a long disease-free interval. Only one patient had recurrent disease within 1-year of primary surgery. The data suggest that bilateral neck exploration at the time of initial operation, in this se... | 4/12/2022 | |
| Current Strategies to Optimize Nutrition and Growth in Newborns and Infants with Congenital Heart Disease A Narrative Review | (1) Objective: This review aims to identify the clinical and practical barriers to optimizing nutrition in newborn infants with congenital heart disease (CHD) and to describe updated evidence-based recommendations for clinical and nutritional management of these patients in a narrative review. (2) R... | 4/12/2022 | |
| Complex Wound Closure in Adult Spinal Deformity Surgery Reduces Complications in High-Risk Patients | CONCLUSIONS: Prophylactic involvement of plastic surgery in ASD surgery wound closure may improve wound outcomes in higher risk patients. A multidisciplinary approach with plastic and spine surgeons may lessen the risk of wound complications in high-risk spine surgeries. | 3/25/2022 | |
| In-hospital outcomes of intercostal nerve cryoablation and surgical stabilization of rib fractures | CONCLUSION: Combining INCA with SSRF may further improve in-hospital outcomes for patients with traumatic rib fractures. | 3/23/2022 | |
| Spatiotemporal diversity and regulation of glycosaminoglycans in cell homeostasis and human disease | Glycosaminoglycans (GAGs) are long, linear polysaccharides that are ubiquitously expressed on the cell surface and in the extracellular matrix of all animal cells. These complex carbohydrates play important roles in many cellular processes and have been implicated in many disease states, including c... | 3/16/2022 | |
| The Effect of TAVR on Left Ventricular and Left Atrial Mechanics in Patients with Aortic Stenosis | Background. Measures of adverse cardiac remodeling, left ventricular global longitudinal strain (LVGLS) and left atrial (LA) phasic function, are predictive of cardiac events in patients with severe aortic stenosis (AS). How these parameters of cardiac function change following TAVR requires further... | 2/24/2022 | |
| Impact of Prior Drug Allergies on the Risk, Clinical Features, and Outcomes of Idiosyncratic Drug-Induced Liver Injury in Adults | CONCLUSION: A prior drug allergy history was not associated with a greater likelihood of developing DILI compared to other causes of acute liver injury. However, the probable DILI patients with a history of prior drug allergy tended to have less severe liver injury and clinical outcomes. The low rat... | 2/5/2022 | |
| Transradial versus transfemoral access for embolization of intracranial aneurysms with the Woven EndoBridge device a propensity score-matched study | CONCLUSIONS: TRA has comparable outcomes, with shorter procedure and fluoroscopy time, to TFA for aneurysm embolization with the WEB device. | 2/4/2022 | |
| Hyperferritinemia and the Extent of Mucormycosis in COVID-19 Patients | Introduction Coronavirus disease 2019 (COVID-19) disease attributed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has shown associations with various fungal opportunistic infections such as mucormycosis, invasive candidiasis, and aspergillosis, which have contributed to the mortali... | 2/1/2022 | |
| Predictive Accuracy of the Nelson Equation via BodPod Compared to Commonly Used Equations to Estimate Resting Metabolic Rate in Adults | Indirect calorimetry (IC) is considered the gold standard for assessing resting metabolic rate (RMR). However, many people do not have access to IC devices and use prediction equations for RMR estimation. Equations using fat free mass (FFM) as a predictor have been developed to estimate RMR, as a st... | 1/31/2022 | |
| Potential-Driven Electrochemical Clearing of Ex Vivo Alkaline Corneal Injuries | CONCLUSIONS: P-ECT may be a means to correct alkaline CCI. Collagen fibril orientation does not change after NaOH exposure or P-ECT, suggesting that no irreversible matrix level fiber changes occur. Further studies are required to determine the mechanism for corneal clearing and to ascertain the opt... | 1/21/2022 | |
| Diagnostic protocols and newer treatment modalities for cluster headache | Cluster Headaches are one of the most arguably severe forms of primary headache syndrome that affects humans. Although it is relatively uncommon, it has a significant impact on the quality of life. It is a multifactorial disease that has risk factors ranging from seasonal changes, lifestyle habits t... | 1/10/2022 | |
| Short- to Intermediate-Term Radiographic Outcomes Following Cotton Osteotomy | The cotton osteotomy or the medial cuneiform opening wedge osteotomy has been a common adjunct procedure in flatfoot reconstruction to correct for forefoot varus or a dorsiflexed first ray. The main goal of the study is to retrospectively review outcomes specifically in the short-intermediate term f... | 1/3/2022 | |
| The Impact of Cochlear Implantation Cognitive Function, Quality of Life, and Frailty in Older Adults | This review examines the relationship between cochlear implantation and cognition and quality of life in older adults, as well as how frailty affects outcomes for older patients with cochlear implants. A growing body of evidence suggests that there is a strong association between hearing loss and co... | 12/16/2021 | |
| Auricular Cartilage Resection for Treatment-Refractory Idiopathic Chronic Chondritis A Case Series | CONCLUSIONS: Surgical excision of diseased cartilage as a result of idiopathic chronic chondritis is an effective treatment in those cases refractory to antibiotics and incision and drainage, and should be considered in the treatment algorithm for similar patients, potentially offering definitive cu... | 12/10/2021 | |
| Caregiver Quality of Life After Cochlear Implantation in Older Adults | CONCLUSIONS: Higher QOL scores were found among caregivers of healthier, female CI recipients. Patient hearing measurements did not correspond with better caregiver QOL. | 12/2/2021 | |
| A Cobalt Phosphine Complex in Five Oxidation States | Here we report electrochemical, spectroscopic, and crystallographic characterization of a redox series of cobalt complexes in five sequential oxidation states. A simple bidentate phosphine ligand, cis-1,2-bis(diphenylphosphino)ethylene (dppv), allows for isolation of the 3+, 2+, 1+, 0, and 1- oxidat... | 11/23/2021 | |
| Short Courses of Antibiotics Are Safe in Necrotizing Soft Tissue Infections | CONCLUSION: Provided adequate surgical debridement, similar outcomes in morbidity and mortality suggest antibiotic courses of 7 days or less are equally safe compared to longer courses. | 10/27/2021 | |
| Non-invasive biomarkers of Fontan-associated liver disease | CONCLUSIONS: In this large, relatively homogeneous adolescent population in terms of age, ethnicity, and Fontan duration, bridging fibrosis was observed in 35% of patients within the first decade post-Fontan. Bridging fibrosis was associated with worse survival. Changes in platelet counts, even year... | 10/25/2021 | |
| Redosing of Fluorescein Sodium Improves Image Interpretation During Intraoperative emEx Vivoem Confocal Laser Endomicroscopy of Brain Tumors | CONCLUSIONS: The decay of the FNa signal is directly associated with image brightness and contrast. The qualitative interpretation scores of images were highest for the FNa redose imaging group. Redosing with FNa to improve the utility of CLE imaging should be considered a safe and beneficial strate... | 10/18/2021 | |
| Effects of previous coronary artery bypass graft surgery on in-hospital mortality in ST-segment elevation myocardial infarction National dataset analysis | CONCLUSION: STEMI patients with previous CABG have a significantly higher IHM compared to those without previous CABG. PPCI improves IHM with no independent mortality disadvantage attributable to previous CABG. | 10/6/2021 | |
| Does Frailty or Age Increase the Risk of Postoperative Complications Following Cochlear Implantation | CONCLUSIONS: CI is safe for elderly and frail patients and carries no additional risk of complications when compared to younger, healthier patients. While medical comorbidities should always be considered perioperatively, this study supports the notion that implantation is low risk in older, frail p... | 10/1/2021 | |
| Clinical outcomes of left bundle branch area pacing compared to right ventricular pacing Results from the Geisinger-Rush Conduction System Pacing Registry | CONCLUSION: LBBAP resulted in improved clinical outcomes compared to RVP. Higher burden of ventricular pacing (>20%) was the primary driver of these outcome differences. | 9/5/2021 | |
| Ototoxicity and Teprotumumab | CONCLUSIONS: This is one of the first descriptive cases of ototoxicity resulting in irreversible sensorineural hearing loss in the setting of treatment with teprotumumab. Periodic audiologic evaluations should be recommended to patients on teprotumumab. | 8/27/2021 | |
| An educational evaluation of learner experiences in dentistry open-book examinations | Introduction The COVID-19 pandemic resulted in substantial global disruptions, with many universities restructuring their examinations to open-book assessments. In this format, learners are allowed to use revision notes, textbooks and other permitted material during their examination. Traditionally,... | 8/27/2021 | |
| Exploring feedback-controlled versus open-circuit electrochemical lipolysis in ex vivo and in vivo porcine fat A feasibility study | CONCLUSIONS: V-ECLL and P-ECLL at the aforementioned dosimetry parameters both achieved fat necrosis by adipocyte membrane lysis and denuclearization. The -2.5 V and -3.5 V P-ECLL treatments created spatially similar fat necrotic effects when compared to the 5 V V-ECLL treatment. Quantitatively, tot... | 8/19/2021 | |
| His-Purkinje Conduction System Pacing in Atrioventricular Block New Insights Into Site of Conduction Block | CONCLUSIONS: HPCSP pacing was successfully performed in 97% of unselected patients with AVB irrespective of the site of conduction block. True infra-Hisian block (distal His-Purkinje conduction disease) is rare. HBP and LBBAP were complementary in achieving stable and low capture thresholds. | 8/16/2021 | |
| Dental implications of some commonly prescribed medicines | Several medicines can have an impact on oral health or have implications for dental treatment. It is important that general dental practitioners review the medicines that their patients are taking and consider their potential impact. In this article we highlight some of the medicines or groups of me... | 8/11/2021 | |
| Exosomes in Atherosclerosis, a Double-Edged Sword Their Role in Disease Pathogenesis and Their Potential as Novel Therapeutics | Cardiovascular disease (CAD) due to atherosclerosis is a major cause of death worldwide. The development of atherosclerosis involves intercellular communication facilitated by exosomes secreted from vascular endothelial cells (VECs), vascular smooth muscle cells (VSMCs), immune cells, and platelets.... | 7/27/2021 | |
| DNA Electrochemistry Charge-Transport Pathways through DNA Films on Gold | Over the past 25 years, collective evidence has demonstrated that the DNA base-pair stack serves as a medium for charge transport chemistry in solution and on DNA-modified gold surfaces. Since this charge transport depends sensitively upon the integrity of the DNA base pair stack, perturbations in b... | 7/26/2021 | |
| Patient-Reported Aesthetic and Psychosocial Outcomes After Microvascular Reconstruction for Head and Neck Cancer | CONCLUSIONS AND RELEVANCE: The findings of this cross-sectional, web-based survey study suggest that osteocutaneous reconstruction and adjuvant therapy independently increase the risk of poor patient-reported long-term aesthetic satisfaction, which correlated with impaired appearance-related psychos... | 7/22/2021 | |
| Smile Outcomes of an Externally Scarless, Intraoral Orthodromic Temporalis Tendon Transfer | Background: Temporalis tendon transfer (TTT) often relies on external incisions in the nasolabial fold, temporal region, or both. Herein, we studied smile outcomes of a TTT technique via a single intraoral incision without external skin incisions. Objective: To measure the difference in static perio... | 7/21/2021 | |
| Thromboembolism, Bleeding, and Mortality Incidence of Direct Oral Anticoagulants Versus Warfarin Postbariatric Surgery | CONCLUSION: The results of our meta-analysis remain hypothesis-generating, providing rationale for future randomized controlled trial design or well-designed comparative observational studies. Currently, it does not support the change in the current recommendation from warfarin to DOACs following ba... | 7/17/2021 | |
| Superior Semicircular Canal Dehiscence Syndrome Following Head Trauma A Multi-institutional Review | CONCLUSION: Head trauma may be a potentiating event for SSCD syndrome. This study advances the hypothesis that these patients likely have underlying radiographic SSCD prior to their trauma, and a traumatic event increases in intra-vestibular or intracranial pressures, unmasking SSCD syndrome. | 7/17/2021 | |
| Cochlear implantation after radiosurgery for vestibular schwannoma | CONCLUSIONS: Most patients who underwent CI following SRS for VS enjoyed access to sound at near-normal levels, with the majority achieving good open-set speech understanding. Implantation can be performed immediately following SRS or in a delayed fashion, depending on hearing status as well as othe... | 7/12/2021 | |
| Surgical Management of Postradiation, Dropped Head Spinal Deformity in Patients with Head and Neck Cancer | CONCLUSIONS: Surgical correction of postradiation dropped head spinal deformity involving anterior and posterior fixation with osteotomies provides improvement in functional and radiographic outcomes as shown in our series. These cases are technically challenging and have a high rate of perioperativ... | 7/10/2021 | |
| An Update on Medical and Surgical Treatments of Parkinsons Disease | Parkinson's disease (PD) is characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta and other neuronal populations. The worldwide prevalence of PD is over 7 million and has been increasing more rapidly than many other neurodegenerative disorders. PD symptoms can b... | 7/5/2021 | |
| Validation of COPDPredict Unique Combination of Remote Monitoring and Exacerbation Prediction to Support Preventative Management of COPD Exacerbations | CONCLUSION: High sensitivity indicates that if there is an exacerbation, COPDPredict™ informs patients and clinicians accurately. The high negative predictive value implies that when an exacerbation is not indicated by COPDPredict™, risk of an exacerbation is low. Thus, COPDPredict™ provides safe, p... | 6/30/2021 | |
| Family integrated care Supporting parents as primary caregivers in the neonatal intensive care unit | Family integrated care (FICare) is a collaborative model of neonatal care which aims to address the negative impacts of the neonatal intensive care unit (NICU) environment by involving parents as equal partners, minimizing separation, and supporting parent-infant closeness. FICare incorporates psych... | 6/28/2021 | |
| Absent pyramidal eminence and stapedial tendon associated with congenital stapes footplate fixation Intraoperative and radiographic findings | CONCLUSIONS: This study identifies a clinically pragmatic association between an absent pyramidal eminence identified on high-resolution CT and the diagnosis of CSFF. In a condition that otherwise generally lacks distinctive radiological features, the absence of a pyramidal eminence on CT in a patie... | 6/25/2021 | |
| Pulmonary embolism in chronic kidney disease and end-stage renal disease hospitalizations Trends, outcomes, and predictors of mortality in the United States | CONCLUSION: The mortality rate and length of stay in pulmonary embolism patients with chronic kidney disease and end-stage renal disease were significantly higher than those in pulmonary embolism patients with normal kidney function. Also, pulmonary embolism patients with chronic kidney disease and ... | 6/23/2021 | |
| Electrochemical safety limits for clinical stimulation investigated using depth and strip electrodes in the pig brain | Objective. Diagnostic and therapeutic electrical stimulation are increasingly utilized with the rise of neuromodulation devices. However, systematic investigations that depict the practical clinical stimulation paradigms (bipolar, two-electrode configuration) to determine the safety limits are curre... | 5/20/2021 | |
| Expert-Level Intracranial Electroencephalogram Ictal Pattern Detection by a Deep Learning Neural Network | Background: Decision-making in epilepsy surgery is strongly connected to the interpretation of the intracranial EEG (iEEG). Although deep learning approaches have demonstrated efficiency in processing extracranial EEG, few studies have addressed iEEG seizure detection, in part due to the small numbe... | 5/20/2021 | |
| An Unusual Cause of Gastrointestinal Perforation in an Adolescent Patient With Beta-Thalassemia on Deferasirox and SARS-CoV-2 Infection | Chelation therapy is recognized as a safe and effective treatment option in patients with beta-thalassemia with iron overload. We report an 18-year-old male with acute abdomen and gastrointestinal bleeding with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection secondary to gastr... | 5/19/2021 | |
| Failure in Cervical Spinal Fusion and Current Management Modalities | Failed fusion in the cervical spine is a multifactorial problem stemming from a combination of patient and surgical factors. Patient-related risk factors such as steroid use, poor bone quality, and smoking can be optimized preoperatively. Age, prior radiation, prior surgery, and underlying genetics ... | 5/17/2021 | |
| Utility of Surveillance Ambulatory Rhythm Monitoring in the Pediatric Fontan Population | Our institution established a Fontan surveillance plan, which included ambulatory rhythm monitoring (ARM) at 6, 10, 13, 16 and 19 years old, for early detection of Fontan-associated complications. We conducted a retrospective chart review of Fontan patients followed at our institution 2014-2018 to d... | 5/8/2021 | |
| Degree of preoperative hearing loss predicts time to early mobilization following vestibular schwannoma microsurgery | CONCLUSION: Following microsurgical removal of VS, preoperative profound hearing loss was associated with a shorter time to postoperative mobilization; however, there were no observed associations with duration or severity of nystagmus and time to hospital discharge. Although not a predictor of nyst... | 4/29/2021 | |
| Linked Clusters of SARS-CoV-2 Variant B1351 - Maryland, January-February 2021 | In late January 2021, a clinical laboratory notified the Maryland Department of Health (MDH) that the SARS-CoV-2 variant of concern B.1.351 had been identified in a specimen collected from a Maryland resident with COVID-19 (1). The SARS-CoV-2 B.1.351 lineage was first identified in South Africa (2) ... | 4/29/2021 | |
| Uptake of telehealth in Parkinsons disease clinical care and research during the COVID-19 pandemic | CONCLUSION: The current results suggest a need for flexibility in conducting office visits and clinical trials in PD patients. Technology has the potential to enhance patient care and convenience, when in-person visits can be challenging. | 4/25/2021 | |
| Frailty and Quality of Life After Cochlear Implantation in Older Adults | CONCLUSIONS: Frailty index does not correlate with hearing scores after cochlear implantation in older adults. Lower frailty index and more improvement in PTA predict better QOL scores after cochlear implantation in older adults. | 4/20/2021 | |
| Early, Postnatal Pulmonary Hypertension Severity Predicts Inpatient Outcomes in Congenital Diaphragmatic Hernia | INTRODUCTION: Pulmonary hypertension (PH) is the major pathophysiologic consequence of congenital diaphragmatic hernia (CDH). We aimed to evaluate the association between early CDH-associated PH (CDH-PH) and inpatient outcomes. | 4/13/2021 | |
| Risk of preterm birth and neonatal outcomes after cerclage placement in triplet pregnancies | CONCLUSIONS: Cerclage placement in triplet pregnancies does not appear to decrease preterm birth rates and seems to increase the risk of neonatal complications. | 4/13/2021 | |
| Pre-intervention SNOT-22 scores predict outcomes in aspirin exacerbated respiratory disease | CONCLUSION: Preoperative SNOT-22 scores may be used as a predictor of postoperative, post-AD patient-reported outcomes in AERD. Patients with mild and moderate disease may derive benefit from surgery and AD alone, while those with severe disease may require additional interventions (e.g., biologics)... | 4/9/2021 | |
| An evaluation of sepsis in dentistry | Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. It is a major health concern and causes substantial morbidity and mortality. It is imperative that the signs of sepsis are identified early in both adult and paediatric patients and appropriately esca... | 3/27/2021 | |
| Elevated proBNP levels are associated with disease severity, cardiac dysfunction, and mortality in congenital diaphragmatic hernia | CONCLUSION: Among CDH patients, elevated proBNP was associated with high-risk defects, ventricular dysfunction, and mortality. ProBNP shows promise as a biomarker in CDH-associated cardiac dysfunction. | 3/22/2021 | |
| Leptomeningeal disease and neurologic death after surgical resection and radiosurgery for brain metastases A multi-institutional analysis | CONCLUSIONS: LMD after surgery and SRS for brain metastases is a clinically significant event with high rates of ND. Classical LMD pattern (vs. nodular) and second LMD failure after salvage treatment were significantly associated with a higher risk of ND. Patients with nLMD treated with salvage foca... | 3/18/2021 | |
| Complicated Post-Partum HELLP Syndrome Causing Acute Renal Failure and a Spontaneous Acute Subdural Hematoma | HELLP syndrome is characterized by hemolysis, elevated liver enzymes, and thrombocytopenia. It is a devastating illness that typically occurs in the third trimester of gestation. We present a unique case of complicated post-partum HELLP syndrome. The patient was a 34-year-old Caucasian G1PO woman at... | 3/17/2021 | |
| Successful WATCHMAN Device Placement Despite Left Atrial Appendage Perforation in Two Cases | The WATCHMAN (Boston Scientific, Marlborough, USA) is a device used to occlude the left atrial appendage (LAA) in patients of non-valvular atrial fibrillation (NVAF) with a high CHA(2)DS(2)-VASc score who are poor candidates for oral anticoagulation. LAA perforation is a well-known complication of t... | 3/15/2021 | |
| Review of operative considerations in spinal cord stem cell therapy | Spinal cord injury (SCI) can permanently impair motor and sensory function and has a devastating cost to patients and the United States healthcare system. Stem cell transplantation for treatment of SCI is a new technique aimed at creating biological functional recovery. Operative techniques in stem ... | 3/12/2021 | |
| Quantifying a frequency modulation response biomarker in responsive neurostimulation | Objective.Responsive neurostimulation (RNS) is an effective treatment for controlling seizures in patients with drug-resistant focal epilepsy who are not suitable candidates for resection surgery. A lack of tools for detecting and characterizing potential response biomarkers, however, contributes to... | 3/10/2021 | |
| Stereoscopic virtual reality does not improve knowledge acquisition of congenital heart disease | Advances in virtual reality have made it possible for clinicians and trainees to interact with 3D renderings of hearts with congenital heart disease in 3D stereoscopic vision. No study to date has assessed whether this technology improved instruction compared to standard 2D interfaces. The purpose o... | 3/7/2021 | |
| Association between insurance status and in-hospital outcomes in patients with out-of-hospital ventricular fibrillation arrest | CONCLUSION: Lack of health insurance is associated with higher in-hospital mortality, lower utilization of ICD and higher cost of hospitalization after OHVFA. | 3/4/2021 | |
| Fetal cardiac dimensions in congenital diaphragmatic hernia relationship with gestational age and postnatal outcomes | CONCLUSIONS: LV hypoplasia in CDH is characterized by reduced MVd from 24 weeks GA. MVd, and the ratio of mitral and tricuspid valve diameters at later gestations, may be potential predictors of disease severity. | 3/2/2021 | |
| Retroperitoneal Liposarcoma Presenting With Malignant Gastric Outlet Obstruction and Acute Pancreatitis A Case Report | Dedifferentiated liposarcomas (DDLPS) are rare, high-grade malignancies that usually originate in the retroperitoneum. Frequently, they present as asymptomatic masses, abdominal distention, abdominal pain, and weight loss. They tend to grow significantly and are usually large in size at the time of ... | 2/25/2021 | |
| Vascularized Bone Grafts for Spinal Fusion-Part 1 The Iliac Crest | CONCLUSION: While long-term follow-up will be required to fully characterize fusion rates and patient morbidity, this innovative surgical option augments spinal fusion in patients with, or at increased risk for, pseudoarthrosis. | 2/22/2021 | |
| Relationship Between Employment Status, Reported Physical Activity, and Sitting Time During COVID-19 Pandemic | CONCLUSIONS: Employment status was not related to physical activity; however, it did affect the amount of time spent sitting, with nonessential employees sitting more and working more hours than essential employees. Because greater amounts of daily total sitting time have been associated with increa... | 2/18/2021 | |
| Mental Disorders, Substance Use Disorders, and Psychotropic Medication Use Among Sudden-Death Victims | CONCLUSIONS: Mental illness, substance use disorders, and psychotropic medication prescriptions were prevalent among sudden-death victims. The health care needs of these individuals may be better addressed by collaborative care for general medical and mental disorders. | 2/17/2021 | |
| Salvage Robotic Roux-en-Y Fistulojejunostomy for Chronic Gastro-Colic Fistula After Laparoscopic Sleeve Gastrectomy | Roux-en-Y fistulojejunostomy (RYFJ) has been proposed as a surgical option for the treatment of a chronic fistula after sleeve gastrectomy but can be technically challenging. The robotic approach in bariatric surgery has emerged as a new rapidly evolving technology and allows performing more complex... | 2/16/2021 | |
| Could myocardial function be predictive of successful extubation in newborns and infants | OBJECTIVE: To investigate the relationship between cardiac function and extubation readiness in infants using speckle tracking echocardiography. | 2/13/2021 | |
| Nasogastric tube feeding after transoral robotic surgery for oropharynx carcinoma | CONCLUSIONS: A majority of patients undergoing TORS do not need NGTF. When NGTF is needed, the duration of use is usually longer than 14 days. Larger tumor size and concurrent bilateral ND are risk factors for NGTF. | 1/29/2021 | |
| Impact of Treatment on Vestibular Schwannoma-Associated Symptoms A Prospective Study Comparing Treatment Modalities | CONCLUSIONS: Limited prospective data exist regarding the progression or resolution of subjective symptoms in those presenting with VS. This study suggests that tinnitus, dizziness or imbalance, and headaches are unlikely to be significantly modified by treatment modality and generally should not be... | 1/26/2021 | |
| Cardiac troponin release following left bundle branch pacing | Left bundle branch pacing (LBBP) has emerged as an alternative to His bundle pacing (HBP) to achieve physiologic ventricular stimulation. The extent of myocardial injury during permanent LBBP implantation is currently not known. The aim of the study was to prospectively assess the extent of myocardi... | 1/23/2021 | |
| International teleproctoring in neurointerventional surgery and its potential impact on clinical trials in the era of COVID-19 legal and technical considerations | CONCLUSIONS: International teleproctoring was successfully implemented in our clinical practice. Its first use provided important insights for establishing this tool in our field. With no clear horizon for lifting the current travel restrictions, teleproctoring has the potential to remove the need f... | 1/14/2021 | |
| Anterior Petrosal Approach for Enlarging Previously Radiated Recurrent Trigeminal Schwannoma 2-Dimensional Operative Video | Trigeminal nerve schwannomas (TNSs) are rare lesions that typically present with symptoms of trigeminal neuropathy or other cranial nerve palsies. These lesions classically have a dumbbell shape, with an anterior component within Meckel's cave and posterior component extending into the posterior fos... | 1/13/2021 | |
| Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations | Hereditary haemorrhagic telangiectasia (HHT) also known as Osler-Weber-Rendu syndrome is an autosomal dominant disorder affecting 1 in 8000 individuals. The eponym recognises the 19th-century physicians William Osler, Henri Jules Louis Marie Rendu and Frederick Parkes Weber who each independently de... | 1/9/2021 | |
| Make Kids Stroke-Smart A Community Based Interventional Study | CONCLUSION: Targeting the younger generation for stroke education is one way to improve community knowledge of stroke symptoms thus increasing the chances that the stroke patient may receive acute stroke therapy. Children can also be used as a conduit to transmit educational information to parents a... | 1/8/2021 | |
| What Factors Predict Upper Body Push to Pull Ratios in Professional Firefighters | Shoulder joint injuries are common for professional firefighters. A potential cause of shoulder injury is an imbalance between anterior (push) and posterior (pull) shoulder joint musculature. Understanding what contributes to these imbalances may help to identify areas needing improvement. The purpo... | 1/8/2021 | |
| Coronary Steal in a Patient With Apical Hypertrophic Cardiomyopathy A Rare Case of Symptomatic Coronary Artery Fistula | This report describes a rare case of multiple left coronary artery to pulmonary artery/left atrial fistulae causing a coronary steal phenomenon. A 58-year-old male with apical hypertrophic cardiomyopathy was seen in an outpatient office for exertional chest pain and dyspnea and subsequently had a po... | 1/7/2021 | |
| Trends, Outcomes, and Predictive Score For Emergency Coronary Artery Bypass Graft Surgery After Elective Percutaneous Coronary Intervention from a Nationwide Dataset | The temporal trends and preprocedural predictors of emergency coronary artery bypass graft surgery (ECABG) after elective percutaneous coronary intervention (PCI) in the contemporary era are largely unknown. From January 2003 to December 2014 elective hospitalizations with PCI as the primary procedu... | 1/1/2021 | |
| Adenocarcinoma of the Sinonasal Tract A Review of the National Cancer Database | Background Sinonasal adenocarcinoma (SNAC) is a rare malignancy arising from mucus-secreting glandular tissue. Limited large-scale studies are available due to its rarity. We evaluated SNAC in the National Cancer Database (NCDB), a source that affords multi-institutional, population studies of rare ... | 12/31/2020 | |
| Surgical Relevance of Pediatric Anterior Clinoid Process Maturation for Anterior Skull Base Approaches | CONCLUSION: The ACP demonstrates stable thickness and a complex triphasic elongation and remodeling pattern with development, the understanding of which may facilitate removal in patients <12. Clinically relevant ACP anatomic variations can occur at any age. | 12/29/2020 | |
| Solitary Fibrous tumor of the lumbar spine mimicking a sequestered disc fragment | Solitary fibrous tumor in the lumbar spine is a rare pathology with non-specific radiographic features, sometimes resulting in misdiagnosis. Our patient was a 41-year old female who presented with low back pain and bilateral leg pain. Initial MRI showed a lesion misdiagnosed for a sequestered disc a... | 12/28/2020 | |
| Is the OUTPUT Sports Unit Reliable and Valid When Estimating Back Squat and Bench Press Concentric Velocity | Merrigan, JJ and Martin, JR. Is the OUTPUT sports unit reliable and valid when estimating back squat and bench press concentric velocity? J Strength Cond Res 36(8): 2069-2076, 2022-This study evaluated the reliability and concurrent validity of the OUTPUT sports inertial unit to measure concentric v... | 12/18/2020 | |
| The impact of wrong-site surgery on dental undergraduate teaching a survey of UK dental schools | CONCLUSION: UK dental schools have increased the emphasis on patient safety by the implementation of national healthcare models, for example WHO checklists and pre-operative briefings. These strategies both aim to improve communication and teamwork. Increased levels of staff supervision foster great... | 12/14/2020 | |
| Trends and outcomes of venous thromboembolism in adult hospitalizations with acute myeloid leukemia analysis of nationwide inpatient sample from 2010 to 2014 | Background: Venous thromboembolism (VTE) occurs frequently in acute myeloid leukemia (AML) patients. There are no population-based studies from the United States (U.S.) analyzing this association. The study aims to analyze the trends, predictors of mortality, and outcomes of VTE in AML patients.Meth... | 12/11/2020 | |
| One-Pot Self-Assembly of Dinuclear, Tetranuclear, and H-Bonding-Directed Polynuclear CobaltII, CobaltIII, and Mixed-Valence CoIICoIII Complexes of Schiff Base Ligands with Incomplete Double Cubane Core | The reaction of 2,6-diformyl-4-methylphenol (DFMF) with 1-amino-2-propanol (AP) and tris(hydroxymethyl)aminomethane (THMAM) was investigated in the presence of Cobalt(II) salts, (X = ClO(4)^(-), CH(3)CO(2)^(-), Cl^(-), NO(3)^(-)), sodium azide (NaN(3)), and triethylamine (TEA). In one pot, the varia... | 12/2/2020 | |
| Self-Assembly of Antiferromagnetically-Coupled CopperII Supramolecular Architectures with Diverse Structural Complexities | The self-assembly of 2,6-diformyl-4-methylphenol (DFMP) and 1-amino-2-propanol (AP)/2-amino-1,3-propanediol (APD) in the presence of copper(II) ions results in the formation of six new supramolecular architectures containing two versatile double Schiff base ligands (H(3)L and H(5)L1) with one-, two-... | 12/1/2020 | |
| A Case of Bilateral Endogenous emCandida dubliniensisem Endophthalmitis Treated with Aggressive Local and Systemic Therapy | Candida dubliniensis is an emerging pathogen implicated in a variety of infections in immunocompromised hosts. A 79-year-old male with autoimmune pancytopenia on chronic oral steroid therapy was admitted for suspected sepsis and started on empirical antibiotics and micafungin. He developed floaters ... | 11/30/2020 | |
| Electrochemical degradation and saponification of porcine adipose tissue | Body contouring achieved via subcutaneous adipose tissue reduction has notably advanced over the past century, from suction assisted lipectomy to techniques with reduced degrees of invasiveness including laser, radiofrequency, high frequency focused ultrasound, cryolipolysis, and drug-based injectio... | 11/28/2020 | |
| Progression in Fontan conduit stenosis and hemodynamic impact during childhood and adolescence | CONCLUSIONS: Fontan conduit CSA decreases as early as 6 months post-Fontan. The minimum Fontan CSA/BSA was not associated with cardiac index or pulmonary artery size but did correlate with % predicted peak oxygen consumption. | 11/22/2020 | |
| Prognostic significance of low muscle volume in patients undergoing surgery for oesophageal cancer | CONCLUSION: BIA is an important prognostic indicator in OC and focused pre-habilitation consequently has strong potential. | 11/13/2020 | |
| Ictal Onset Signatures Predict Favorable Outcomes of Laser Thermal Ablation for Mesial Temporal Lobe Epilepsy | Background: Laser interstitial thermal therapy (LiTT) has emerged as a minimally invasive option for surgical treatment of refractory epilepsy. However, LiTT of the mesial temporal (MT) structures is still inferior to anterior temporal lobectomy (ATL) in terms of postoperative outcome. In this pilot... | 11/12/2020 | |
| Prospective Study of Disease-Specific Quality-of-Life in Sporadic Vestibular Schwannoma Comparing Observation, Radiosurgery, and Microsurgery | CONCLUSIONS: In this prospective longitudinal study investigating differences in QOL outcomes among VS treatment groups using the disease-specific PANQOL instrument, treatment did not modify QOL in most domains. Microsurgery may confer an advantage with regard to patient anxiety, presumably relating... | 11/12/2020 | |
| Neuro-Ophthalmic Complications in Patients Treated With CTLA-4 and PD-1PD-L1 Checkpoint Blockade | CONCLUSION: This study describes the variable neuro-ophthalmic adverse events associated with use of immune checkpoint inhibitors and contributes a more thorough understanding of their clinical presentations and treatment outcomes. We expect this will increase awareness of these drug complications a... | 11/2/2020 | |
| Conservative Composite Resin Restoration for Proximal Caries - Two Case Reports | The paradigms of contemporary caries management have shifted to minimal intervention dentistry. Conservative restorative procedures are recommended to replace the complete removal of all carious tissues in the management of dental caries. This article reports two clinical cases of conservative resto... | 10/29/2020 | |
| Reliability of preoperative venous mapping ultrasonography in predicting for autogenous arteriovenous fistula maturation | CONCLUSIONS: Despite the national fistula-first initiatives, most patients still undergo access via catheter at the initiation of hemodialysis. The use of routine preoperative venous mapping does not predict successful primary maturation. Also, no clinically useful predictor of fistula maturation wa... | 10/22/2020 | |
| Cochlear Implants and Magnetic Resonance Imaging Experience With Over 100 Studies Performed With Magnets in Place | CONCLUSIONS: MRI with CI or ABI magnets in place is associated with a low prevalence of adverse events when performed in a controlled setting. Many partial magnet displacements can be corrected with firm manual pressure. Devices with magnets that align with the field within their housing were not as... | 10/12/2020 | |
| Accuracy of Commonly Used Age-Predicted Maximal Heart Rate Equations | Age-predicted maximal heart rate (APMHR) is an essential measure for healthcare professionals in determining cardiovascular response to exercise testing, exertion, and prescription. Although multiple APMHR prediction equations have been validated for specific populations, the accuracy of each within... | 10/12/2020 | |
| Partial high frequency nerve block decreases neuropathic signaling following chronic sciatic nerve constriction injury | Objective.High frequency (HF) block can quickly and reversibly stop nerve conduction. We hypothesized HF block at the sciatic nerve would minimize nociception by preventing neuropathic signals from reaching the central nervous system.Approach.Lewis rats were implanted with a constriction cuff and a ... | 10/7/2020 | |
| Osteomyelitis-Discitis at the Thoracolumbar Junction and the Development of Postinfectious Spinal Deformity A Surgical Case Series | CONCLUSIONS: Given the proclivity for kyphotic deformity at the TL junction, patients may benefit from long segment instrumentation in addition to decompression at the initial surgery. Laminectomy alone may hasten kyphosis progression. | 9/28/2020 | |
| The Role of Machine Learning in Spine Surgery The Future Is Now | The recent influx of machine learning centered investigations in the spine surgery literature has led to increased enthusiasm as to the prospect of using artificial intelligence to create clinical decision support tools, optimize postoperative outcomes, and improve technologies used in the operating... | 9/25/2020 | |
| Basal impulses findings from the last twenty years on impulsivity and reward pathways using deep brain stimulation | CONCLUSIONS: As newer, more refined DBS technology emerges, large-scale prospective studies specifically aimed at treatment of impulsivity disorders are needed. | 9/25/2020 | |
| Asynchronous video messaging promotes family involvement and mitigates separation in neonatal care | CONCLUSIONS: Asynchronous video messaging improves parental experience, emotional closeness to their baby and builds supportive relationships between families and staff. Asynchronous video supports models of family integrated care and can mitigate family separation, which could be particularly relev... | 9/15/2020 | |
| Static Magnetic Fields within Spinal Interbody Cages for the Promotion of Spinal Arthrodesis A Pilot Study | CONCLUSIONS: A spinal interbody cage containing a neodymium iron boron magnet for the production of a local SMF is feasible. Preliminary data suggests enhanced bone formation, bone density, and osseointegration of the graft. | 9/6/2020 | |
| Effect of Sex Difference on Discordance Between Instantaneous Wave-Free Ratio and Fractional Flow Reserve | CONCLUSIONS: Despite similar prevalence of overall concordance and discordance between men and women, iFR+/FFR- discordance was higher in women and iFR-/FFR+ discordance was higher in men. Multivariable analysis showed female sex to be independent predictor of iFR+/FFR- discordance. | 8/26/2020 | |
| Optical Flow Estimation Improves Automated Seizure Detection in Neonatal EEG | CONCLUSIONS: This work presents a novel approach to improving automated seizure detection algorithms used during neonatal video EEG monitoring. This artifact detection mechanism can improve the ability of a seizure detector algorithm to distinguish between artifact and true seizure activity. | 8/19/2020 | |
| Increase in cochlear implant electrode impedances with the use of electrical stimulation | CONCLUSION: In this study, we report two cases of electrode impedances increasing as a function of device use. Numerous management strategies were employed to reduce this effect but none prevailed; a clear pathophysiologic mechanism remains elusive. Further study into the cause of this electrode imp... | 8/5/2020 | |
| Anticoagulant Medications and Operative Subdural Hematomas A Retrospective Cohort Study Evaluating Reoperation Rates | CONCLUSIONS: Anticoagulant use was not associated with an increased reoperation rate, suggesting that reversal of AC may have eliminated the hemorrhagic risk conferred by these medications. Patients on ACs were significantly older, harbored more medical comorbidities, and had a worse functional outc... | 7/26/2020 | |
| Congenital Fusion of Dens to T3 Vertebra in Klippel-Feil Syndrome | CONCLUSION: This is the first reported case of Klippel-Feil syndrome with fusion of all cervical vertebrae down to T3. We recommend surgery for advanced cases of myelopathy or radiculopathy due to stenosis and spinal instability. | 7/12/2020 | |
| Experience With the Pipeline Embolization Device for Posterior Circulations Aneurysms A Multicenter Cohort Study | CONCLUSION: This multicenter study shows that PED for the treatment of posterior circulation is preferentially used for the treatment of fusiform and dissecting/blister aneurysm morphologies. Despite the challenges presented by these less-common morphologies, flow diversion may be performed with a n... | 7/7/2020 | |
| Comparison of PED and FRED flow diverters for posterior circulation aneurysms a propensity score matched cohort study | CONCLUSION: Comparative analysis of PED and FRED for the treatment of unruptured posterior circulation aneurysms did not identify significant differences in aneurysm occlusion or neurologic complications. Variations in functional outcomes warrant additional investigations. | 7/3/2020 | |
| Sepsis Unmasking Fahrs Disease | Fahr's disease is a sporadic or familial neurodegenerative disorder characterized by symmetrical calcification of cerebral structures, particularly the basal ganglia, cerebellar dentate nuclei and surrounding white matter, in the absence of metabolic causes of calcification. We report the case of a ... | 6/29/2020 | |
| Missed opportunity to diagnose HIV with emPneumocystis cariniiem pneumonia as its sequela | Pneumocystis carinii pneumonia (PCP) is an opportunistic infection of the lung occurring primarily in patients with HIV infection with a CD4 cell count <200 mm³, solid organ transplant recipients and those taking immunosuppressive therapy. The 1980s heralded the HIV pandemic, turning PCP into a majo... | 6/27/2020 | |
| Retrospective Cohort Analysis of the Army Physical Fitness Test and the Occupational Physical Assessment Test in Reserve Officer Training Corps Cadets A Brief Report | CONCLUSIONS: Sex differences and varied relationships among individual events on two common military fitness test batteries were observed. Lower performances on APFT and OPAT by women may suggest the need to evaluate potential training methods to assist women in reaching their desired MOS. Further, ... | 5/29/2020 | |
| Intravenous Access in Gastrointestinal Hemorrhage A Multidisciplinary Quality Improvement Initiative Led by Emergency Department Nurses and Internal Medicine Physicians | CONCLUSIONS: Carefully directed education of ED physicians and nurses with monthly feedback was effective in improving appropriate intravenous placement in patients with GIH. | 5/21/2020 | |
| Early postnatal changes of circulating N-terminal-pro-B-type natriuretic peptide in neonates with congenital diaphragmatic hernia | CONCLUSION: NT-proBNP analysis in the first 48 h of life may be useful to assess PH and cardiac dysfunction in CDH newborns and to predict the need for ECMO support. | 5/14/2020 | |
| Deprivation increases perforation risk in paediatric appendicitis | Acute appendicitis is the most common surgical emergency in childhood. Perforation of the appendix conveys a worse outcome.This case-control study investigated the relationship between deprivation and appendiceal perforation in children in the West of Scotland.All children undergoing acute appendice... | 4/29/2020 | |
| The Utility of a Diagnostic Angiogram Following Mechanical Thrombectomy for Treatment of Acute Ischemic Stroke | CONCLUSION: Angiographic imaging of non-target vessels following mechanical thrombectomy identified previously unknown vascular pathology in 4.4% of procedures and resulted in a clinical management change in 3.3% of cases. | 4/24/2020 | |
| What do Firefighting Ability Tests Tell Us About Firefighter Physical Fitness A Systematic Review of the Current Evidence | Fyock-Martin, MB, Erickson, EK, Hautz, AH, Sell, KM, Turnbaugh, BL, Caswell, SV, and Martin, JR. What do firefighting ability tests tell us about firefighter physical fitness? A systematic review of the current evidence. J Strength Cond Res 34(7): 2093-2103, 2020-The firefighting profession is a phy... | 4/15/2020 | |
| Robot-assisted stereoelectroencephalography exploration of the limbic thalamus in human focal epilepsy implantation technique and complications in the first 24 patients | CONCLUSIONS: Using judiciously planned robot-assisted SEEG, the authors demonstrate the safety of electrophysiological sampling from various thalamic nuclei for research recordings, presenting a technique that avoids implanting additional depth electrodes or compromising clinical care. With these re... | 4/3/2020 | |
| The minimally invasive paramedian approach for foraminal disc herniation | Foraminal disc herniation presents with an operative challenge, as it often requires facetectomy, which can result in segmental instability. The intraforaminal approach includes partial pars resection and medial facetectomy and allows for direct visualization of the nerve roots and herniated disc in... | 4/1/2020 | |
| Intracranial Epidural Abscess in a 9-Year-Old Boy With Precocious Puberty and Use of Continuous Positive Airway Pressure | Intracranial extension of rhinosinusitis is rare in children. We report a 9-year-old immunocompetent boy with central precocious puberty and obstructive sleep apnea-hypopnea syndrome who developed an intracranial epidural abscess secondary to rhinosinusitis while on continuous positive airway pressu... | 4/1/2020 | |
| Vertebral artery aneurysms and the risk of cord infarction following spinal artery coverage during flow diversion | CONCLUSIONS: FD aneurysm treatment in the posterior circulation with coverage of ASA or PSA/LSA was not associated with higher rates of occlusion of these branches or any instances of cord infarction. | 3/29/2020 | |
| Procedural, pregnancy, and short-term outcomes after fetal aortic valvuloplasty | CONCLUSIONS: FAV is an often successful but high-risk procedure. Multiple cardiac punctures are associated with increased complication and fetal mortality rates. Later GA at intervention and technical success were independently associated with increased odds of live birth. However, performing the pr... | 3/28/2020 | |
| A Population-Level Analysis of Pituitary Carcinoma from the National Cancer Database | Objectives Pituitary carcinoma is a rare entity with fewer than 200 total cases reported in the English literature. Analysis of the population-level data from the National Cancer Database (NCDB) affords the opportunity to study this poorly understood tumor type. Methods The NCDB was queried for site... | 3/25/2020 | |
| The biophysical effects of localized electrochemical therapy on porcine skin | CONCLUSION: We demonstrated the production of in situ acid and base in skin occurring via ECT. The effects chemically and precisely alter collagen structure through denaturation, giving insight on the potential of ECT as a simple, low-cost, and minimally-invasive means to remodel skin and treat scar... | 3/15/2020 | |
| Early Left Ventricular Dysfunction and Severe Pulmonary Hypertension Predict Adverse Outcomes in Low-Risk Congenital Diaphragmatic Hernia | CONCLUSIONS: Early left ventricular dysfunction and severe pulmonary hypertension are independent predictors of adverse outcomes among "low-risk" congenital diaphragmatic hernia infants. Early recognition may lead to interventions that can improve outcome in this at-risk cohort. | 3/14/2020 | |
| Psychosocial and Physiologic Characteristics of Patients with Non-epileptic Events A Retrospective Study | Background The main focus of this study is to aid early identification of psychogenic non-epileptic seizure (PNES) patients by identifying physical and psychosocial characteristics to reduce the health care burden, to reduce the unnecessary use of anti-epileptic medications and their side effects, a... | 3/7/2020 | |
| Myocardial strain on admission predicts disease severity in infants hospitalized for bronchiolitis | CONCLUSIONS: Bronchiolitis is associated with myocardial impairment. Cardiac function is related to disease severity and outcome. | 3/6/2020 | |
| Pipeline Embolization Device Versus Stent-Assisted Coiling for Intracranial Aneurysm Treatment A Retrospective Propensity Score-Matched Study | CONCLUSION: PED placement and SAC offer equally efficacious occlusion rates, functional outcomes, procedural complication rates, and cost profiles for small unruptured anterior circulation saccular aneurysms which do not involve the anterior communicating artery. | 3/6/2020 | |
| Common Pitfalls in Subtalar Joint Preparation for Arthrodesis via Sinus Tarsi Approach | This cadaveric study assessed factors that could lead to nonunions in subtalar joint arthrodesis. The purpose of this study was to assist surgeons in achieving sufficient joint preparation in hopes to achieve more frequent arthrodesis of the subtalar joint. We evaluated the influence of experience i... | 3/5/2020 | |
| Tuning coordination chemistry through the second sphere in designed metallocoiled coils | The metal hydration state within a designed coiled coil can be progressively tuned across the full integer range (3 → 0 aqua ligands), by careful choice of a second sphere terminal residue, including the lesser used Trp. Potential implications include a four-fold change in MRI relaxivity when applie... | 3/5/2020 | |
| Incidence, risk factors, and outcomes of endoscopic sinus surgery after endoscopic skull-base surgery | CONCLUSION: A significant proportion of patients develop clinically significant sinusitis after endoscopic SBS for neoplasms with combined sinonasal and skull base involvement and may benefit from rESS. Intervention occurred, on average, 3.5 years after initial tumor resection. Malignant pathology, ... | 2/28/2020 | |
| Evidence for Dietary Agmatine Sulfate Effectiveness in Neuropathies Associated with Painful Small Fiber Neuropathy A Pilot Open-Label Consecutive Case Series Study | Peripheral neuropathies associated with painful small fiber neuropathy (SFN) are complex conditions, resistant to treatment with conventional medications. Previous clinical studies strongly support the use of dietary agmatine as a safe and effective treatment for neuropathic pain. Based on this evid... | 2/28/2020 | |
| Myocardial strain in newborn infants with tracheomalacia due to vascular rings, a pilot study | CONCLUSIONS: In cases of VR with severe tracheomalacia RV and LV myocardial strain is reduced, suggesting secondary cardiac dysfunction. | 2/26/2020 | |
| In vitro safety of ketotifen as a topical nasal rinse | CONCLUSION: Topical application of ketotifen to an in vitro model of sinonasal epithelium is safe, as evaluated by CBF and lactate dehydrogenase. Ketotifen is neither ciliotoxic nor ciliostimulatory, and no long-term cellular toxicity was observed. Ketotifen may have promise as a topical nasal rinse... | 2/23/2020 | |
| ViroPanel Hybrid Capture and Massively Parallel Sequencing for Simultaneous Detection and Profiling of Oncogenic Virus Infection and Tumor Genome | Precision cancer medicine aims to classify tumors by site, histology, and molecular testing to determine an individualized profile of cancer alterations. Viruses are a major contributor to oncogenesis, causing 12% to 20% of all human cancers. Several viruses are causal of specific types of cancer, p... | 2/19/2020 | |
| Focal Management of Large Brain Metastases and Risk of Leptomeningeal Disease | CONCLUSIONS: Surgery is appropriate for certain brain metastases, but S + SRS may increase LMD risk compared with FSRT alone. Because S + SRS and FSRT seem to have similar LC, FSRT may be a viable alternative to S + SRS in select patients with large brain metastases. | 2/14/2020 | |
| Implementation of a multidisciplinary perinatal emergency response team improves time to definitive obstetrical evaluation and fetal assessment | BACKGROUND: Trauma is the leading cause of nonobstetric death during pregnancy and is associated with an increased risk of maternal and fetal mortality. In an effort to improve the delivery of care to pregnant trauma patients, we developed an institutional multidisciplinary quality initiative design... | 2/12/2020 | |
| Penile ring entrapment - A true urologic emergency Grading, approach, and management | Penile rings are used to sustain erection in order to enhance sexual pleasure. They work by reducing the outflow of blood from the cavernosal tissue. However, if left for extended periods of time severe edema, urethral fistula, gangrene, and even complete loss of the distal penis can ensue, this is ... | 2/5/2020 | |
| The Influence of Vestibular Schwannoma Tumor Volume and Growth on Hearing Loss | CONCLUSION: Larger initial VS tumor volume was associated with poorer hearing at baseline. Larger initial tumor volume was also associated with the development of nonserviceable hearing during observation in a univariable setting; however, this association was not statistically significant after adj... | 1/29/2020 | |
| Routine Surveillance Catheterization is Useful in Guiding Management of Stable Fontan Patients | We developed a Fontan surveillance catheterization protocol as part of routine assessment of stable patients 10 years after Fontan completion. The surveillance catherization includes hemodynamic assessment with inhaled nitric oxide, angiography, liver biopsy, and transcatheter intervention if indica... | 1/26/2020 | |
| Practical Application of Recent Advances in Diagnostic, Prognostic, and Therapeutic Modalities for Spinal Cord Injury | CONCLUSIONS: Recent advances in accurate, timely, and practical classification methods of acute spinal cord injury will assist in the development of novel treatment approaches for both acute and chronic injury alike. | 1/14/2020 | |
| Monitoring Cochlear Nerve Integrity During Vestibular Schwannoma Microsurgery in Real-Time Using Cochlear Implant Evoked Auditory Brainstem Response and Streaming Neural Response Imaging | CONCLUSIONS: This report demonstrates the feasibility of using real-time NRI and eABR with a CI to facilitate preservation of the cochlear nerve during VS microsurgery. Using this method to mitigate cochlear nerve trauma during microsurgery may preserve the option of CI for hearing rehabilitation. | 1/11/2020 | |
| Rate-controlled intraventricular endoscopic irrigation via bipolar foot pedal activation technical note | Irrigation during intraventricular endoscopic surgery is critical for visualization, with normal intracranial pressure maintained by balancing fluid ingress and egress. Although irrigation is typically achieved through manual manipulation of inexact stopcocks, the authors have developed a rate-contr... | 12/28/2019 | |
| Creating a maternal cardiac center of excellence a call to action | In contrast to most industrialized countries, maternal mortality in the USA is rising. Cardiovascular disease, both acquired heart disease (e.g. coronary disease, arrhythmias, and heart failure), as well as congenital heart disease survivors, are all potentially important factors in explaining this ... | 12/27/2019 | |
| Not a fungi to be with Shiitake mushroom flagellate dermatitis | Shiitake dermatitis is a rare adverse cutaneous reaction to the ingestion of raw or undercooked shiitake mushrooms (Lentinula edodes). We report the case of a patient who developed a striking linear flagellate dermatitis without urticaria three days after returning from a trip from Tokyo where he ha... | 12/23/2019 | |
| Predictor of 90-day functional outcome after mechanical thrombectomy for large vessel occlusion stroke NIHSS score of 10 or less at 24 hours | CONCLUSIONS: An NIHSS score ≤ 10 at 24 hours after mechanical thrombectomy was independently associated with good functional outcome at 90 days. | 12/21/2019 | |
| Utility of platelet function testing in stent-assisted coiling of cerebral aneurysms | CONCLUSION: In patients where the pharmacy-mediated antiplatelet protocol was followed, the thromboembolic complication rate was 1.8%. This complication rate compares favorably to those reported in large contemporary series. Nevertheless, the pharmacy-mediated protocol places a significant burden on... | 12/21/2019 | |
| Rhythmic ictal nonclonic hand RINCH motions in general EMU patients with focal epilepsy | CONCLUSION: The RINCH motions are a common sign in focal seizures and should be distinguished from other types of manual automatism as they carry a strong lateralizing value. | 12/19/2019 | |
| Cochlear Implantation in Craniometaphyseal Dysplasia | CONCLUSION: This report describes the first description of CI for CMD. Despite the extensive radiologic abnormalities, the patient has demonstrated excellent benefit from implantation. Further study of rare temporal bone dysplasias, such as CMD, is critical to better characterize the progression of ... | 12/14/2019 | |
| Stent treatment of ostial branch pulmonary artery stenosis initial and medium-term outcomes and technical considerations to avoid and minimise stent malposition | CONCLUSION: Ostial branch pulmonary artery stenosis may require additional angiography to accurately define the ostial stenosis. Treatment with stents is effective but carries high rates of stent malposition. | 12/14/2019 | |
| Chronic rhinosinusitis precipitated by tumor necrosis factor alpha inhibitors is the phenotype of chronic rhinosinusitis without nasal polyps | CONCLUSION: CRSαi exhibits structured histopathology more similar to CRSsNP. In the appropriate clinical context, it may be reasonable that the medical regimen for these patients be focused on a more antineutrophilic, macrolide-based approach. This study provides insight into the inflammatory enviro... | 12/4/2019 | |
| Predicting the risk of kidney stone formation in the nephron by reverse engineering | Although most kidney stones are found in the calyx, they are usually initiated upstream in the nephron by precipitation there of certain incipient mineral phases. The risk of kidney stone formation can thus be indicated by changes in the degree of saturation of these minerals in the nephron fluid. T... | 11/28/2019 | |
| Giant Symptomatic Meningocele as a Delayed, Adult Complication of Lipomyelomeningocele | CONCLUSIONS: Symptomatic meningocele may present in a long-delayed fashion in adult patients with a history of spina bifida. Surgical treatment may provide symptomatic benefit. | 11/25/2019 | |
| Flow Diversion for Treatment of Partially Thrombosed Aneurysms A Multicenter Cohort | CONCLUSIONS: Flow diversion treatment of PTIA has adequate efficacy along with a reasonable safety profile. Aneurysms harboring large amounts of pretreatment thrombus were associated with lower rates of complete occlusion. | 11/25/2019 | |
| Durability of Hearing Preservation Following Microsurgical Resection of Vestibular Schwannoma | CONCLUSION: Microsurgical resection provides excellent tumor control and durable long-term hearing in those with AAO-HNS class A or B hearing postoperatively. The paradigm of proactive microsurgical resection-when the tumor is small and hearing is good-hinges on the surgeon's ability to preserve res... | 11/15/2019 | |
| Risk Factors for Urinary Tract Infection or Pneumonia After Admission for Traumatic Subdural Hematoma at a Level I Trauma Center Large Single-Institution Series | CONCLUSIONS: Patients with prolonged hospitalizations and/or intensive care unit stays were more likely to experience UTIs and pneumonia. Male gender and younger age were protective against UTI, and higher GCS was protective against pneumonia. These data may aid the identification and treatment of a... | 11/13/2019 | |
| Infective Endocarditis of a Left Ventricular Myxoma in a Heroin User | Infected cardiac myxomas are rare and can have disastrous sequelae; urgent surgical resection is typically indicated. We report the case of a 43-year-old user of intravenous heroin who presented with weakness and dyspnea. He was diagnosed with infective endocarditis of a myxoma attached to the left ... | 11/12/2019 | |
| Human MYD88L265P is insufficient by itself to drive neoplastic transformation in mature mouse B cells | MYD88 L265P is the most common mutation in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) and one of the most frequent in poor-prognosis subtypes of diffuse large B-cell lymphoma (DLBCL). Although inhibition of the mutated MYD88 pathway has an adverse impact on LPL/WM and DLBCL ce... | 11/8/2019 | |
| The CoDiNOS trial protocol an international randomised controlled trial of intravenous sildenafil versus inhaled nitric oxide for the treatment of pulmonary hypertension in neonates with congenital diaphragmatic hernia | INTRODUCTION: Congenital diaphragmatic hernia (CDH) is a developmental defect of the diaphragm that impairs normal lung development, causing pulmonary hypertension (PH). PH in CDH newborns is the main determinant for morbidity and mortality. Different therapies are still mainly based on 'trial and e... | 11/8/2019 | |
| The effects of exercise on mood and prefrontal brain responses to emotional scenes in smokers | The benefits of exercise for smokers attempting to quit are partially dependent on physical activity levels prior to cessation. Mood disturbances can manifest within 30 min of smoking a cigarette and contribute to negative reinforcement of smoking behavior over time, whereas a single bout of aerobic... | 11/1/2019 | |
| Primary Skin Closure after Repair of Hollow Viscus Injuries | Decisions regarding whether to close the skin in trauma patients with hollow viscus injuries (HVIs) are based on surgeon discretion and the perceived risk for an SSI. We hypothesized that leaving the skin open would result in fewer wound complications in patients with HVIs. We performed a retrospect... | 10/29/2019 | |
| Multi-frequency Electrocochleography Measurements can be Used to Monitor and Optimize Electrode Placement During Cochlear Implant Surgery | CONCLUSION: We present a report on simultaneous multi-frequency ECOG monitoring during cochlear implant surgery. Multi-frequency ECOG can be used to differentiate between electrode trauma and the advancement of the apical electrode beyond the CM source in the cochlea. | 10/24/2019 | |
| Effect of a prospective opioid reduction intervention on opioid prescribing and use after radical prostatectomy results of the Opioid Reduction Intervention for Open, Laparoscopic, and Endoscopic Surgery ORIOLES Initiative | CONCLUSIONS: A prospective, evidence-based intervention reduced post-discharge opioid prescribing and use, while increasing disposal after RP. Risk factors for increased opioid use were identified. The results support expanding the use of evidence-based opioid reduction interventions to other surgic... | 10/24/2019 | |
| Prevalence of Acute Kidney Injury in Neonates with Congenital Diaphragmatic Hernia | CONCLUSIONS: AKI is common in CDH cases treated in our centre and is associated with adverse outcomes. Potentially modifiable risk factors include nephrotoxic medication exposure. Prevention and early recognition of contributory factors for AKI may improve outcomes in CDH. | 10/23/2019 | |
| Clinical Implications of Carcinoma In Situ in Sinonasal Inverted Papilloma | CONCLUSIONS: IPwCIS represents the most severe degree of dysplasia prior to malignant transformation and is associated with higher recurrence rate and multifocal involvement but low rate of conversion to invasive carcinoma. The need for adjuvant therapy remains controversial, and further research in... | 10/23/2019 | |
| Does Ossification of the Posterior Longitudinal Ligament Progress After Fusion | Starting in the 1960s, ossification of the posterior longitudinal ligament (OPLL) became more commonly diagnosed in Japan. The disease is characterized by a gradual increase in calcification of the posterior longitudinal ligament with the eventual sequelae of cervical canal stenosis and myelopathy. ... | 10/15/2019 | |
| Cervical Spine Deformity Correction Techniques | Cervical kyphotic deformity can be a debilitating condition with symptoms ranging from mechanical neck pain, radiculopathy, and myelopathy to impaired swallowing and horizontal gaze. Surgical correction of cervical kyphosis has the potential to halt progression of neurological and clinical deteriora... | 10/15/2019 | |
| Impact of surgical volume and surgical outcome assessing registers on the quality of thyroid surgery | The available evidence concerning the relationship between volume and outcome for thyroid surgery is assessed in this article. Morbidity forms the principal surrogate marker of thyroid surgery quality for which postoperative hypocalcaemia and recurrent laryngeal nerve injuries are most commonly repo... | 9/19/2019 | |
| A somatic mutation in MEN1 gene detected in periventricular nodular heterotopia tissue obtained from depth electrodes | Periventricular nodular heterotopia (PNH) is a common structural malformation of cortical development. Mutations in the filamin A gene are frequent in familial cases with X-linked PNH. However, many cases with sporadic PNH remain genetically unexplained. Although medically refractory epilepsy often ... | 9/7/2019 | |
| Involvement of the Cochlear Aqueduct by Jugular Paraganglioma Is Associated With Sensorineural Hearing Loss | CONCLUSIONS: Cochlear aqueduct involvement by JP is associated with SNHL in the absence of inner ear fistula, vestibulocochlear nerve involvement, or brainstem compression. Correlation with operative findings or histopathologic evidence of tumor involvement may validate this intriguing imaging findi... | 8/31/2019 | |
| Delayed Tumor Growth in Vestibular Schwannoma An Argument for Lifelong Surveillance | CONCLUSIONS: Delayed growth encompassed 8.1% of growing VSs and 3.9% of all observed tumors. Patients with delayed growth exhibited slower growth rates compared with those who were diagnosed with growth early in their observation course. These findings support the need for lifelong surveillance of u... | 8/31/2019 | |
| Congenital diaphragmatic hernia-associated cardiac dysfunction | There is increasing evidence that cardiac dysfunction is a key contributor to CDH pathophysiology. Dysfunction in both right and left ventricles is common in the early neonatal period, contributes to clinical disease severity, and is associated with adverse outcomes including death and ECMO use. Ear... | 8/18/2019 | |
| Propofol Formulation Affects Myocardial Function in Newborn Infants | This study aimed to evaluate the effects of propofol in diluted and undiluted formulations on cardiac function in infants. Infants > 30 days received propofol sedation for central line insertion. Cases were divided into two groups: those who received undiluted 1% propofol (P1%); and those who receiv... | 8/16/2019 | |
| Ventricular Dysfunction Is a Critical Determinant of Mortality in Congenital Diaphragmatic Hernia | Rationale: Congenital diaphragmatic hernia (CDH) is an anomaly with a high morbidity and mortality. Cardiac dysfunction may be an important and underrecognized contributor to CDH pathophysiology and determinant of disease severity.Objectives: Our aim was to investigate the association between early,... | 8/15/2019 | |
| Selective Formation of Porous Pt Nanorods for Highly Electrochemically Efficient Neural Electrode Interfaces | The enhanced electrochemical activity of nanostructured materials is readily exploited in energy devices, but their utility in scalable and human-compatible implantable neural interfaces can significantly advance the performance of clinical and research electrodes. We utilize low-temperature selecti... | 8/2/2019 | |
| Cardiopulmonary fitness predicts postoperative major morbidity after esophagectomy for patients with cancer | Surgery for radical treatment of esophageal cancer (EC) carries significant inherent risk. The objective identification of patients who are at high risk of complications is of importance. In this study the prognostic value of cardiopulmonary fitness variables (CPF) derived from cardiopulmonary exerc... | 7/26/2019 | |
| Loss of consciousness at onset of aneurysmal subarachnoid hemorrhage in good-grade patients | Loss of consciousness (LOC) at presentation with aneurysmal subarachnoid hemorrhage (aSAH) has been associated with early brain injury and poor functional outcome. The impact of LOC on the clinical course after aSAH deserves further exploration. A retrospective analysis of 149 aSAH patients who were... | 7/24/2019 | |
| A Cross-Sectional Survey of the North American Skull Base Society Part 3 The State of Lateral Skull Base Surgery Training in North America | Introduction Optimal management of vestibular schwannoma (VS) demands involvement of an experienced multidisciplinary team. As the number of training programs in neurotology and skull base neurosurgery continues to rise, ensuring that trainees are capable of evidence-based decision-making and treatm... | 7/19/2019 | |
| Sinonasal mucoepidermoid carcinoma a review of the National Cancer Database | CONCLUSION: Mucoepidermoid carcinoma is the most common salivary gland malignancy but a rare sinonasal malignancy, with 5-year survival for SN-MEC approximating 50%. A significant proportion of patients present with advanced disease. Both socioeconomic factors and tumor characteristics are associate... | 7/18/2019 | |
| Novel synchronous nasal involvement of inverted papilloma and recurrent respiratory papillomatosis with confirmed human papillomavirus isolated from nasal septum and middle turbinate a case report | CONCLUSIONS: This report emphasizes the importance of considering a broad differential diagnosis in patients with papillomata, and obtaining comprehensive histopathologic evaluation of lesions in multiple subsites in order to rule out inverted papilloma or overt malignant transformation, particularl... | 7/16/2019 | |
| The intracranial correlate of the 14amp;6sec positive spikes normal scalp EEG variant | CONCLUSIONS: The 14&6/sec positive spikes variant correlates with bursts of negative polarity spikes in the ipsilateral hippocampus. | 7/15/2019 | |
| Reimbursement patterns for neurosurgery Analysis of the NERVES survey results from 2011-2016 | CONCLUSION: These data demonstrate neurosurgical reimbursement and productivity have trended down during a time that increases in productivity and reimbursement were predicted. This phenomenon is most notable in academic practices compared to private or hospital based practices. Prospective analyses... | 7/15/2019 | |
| Haplotype analysis of SERPINE1 gene Risk for aneurysmal subarachnoid hemorrhage and clinical outcomes | CONCLUSION: The results suggested an important regulatory role of the SERPINE1 gene polymorphism in clinical outcomes of aSAH. | 7/4/2019 | |
| Time of Surgery in the Outcome of Cervical Spinal Cord Injury the University of Puerto Rico Experience | CONCLUSION: Traumatic cervical spinal cord injury is associated with high mortality and morbidity. Early surgery was not associated with an improved neurological outcome at long-term follow-up. The benefit of early surgery was seen only in terms of decreasing each patient's length of hospital stay. | 7/2/2019 | |
| Interventions to Increase the Rate of Influenza and Pneumococcal Vaccination in Patients with Chronic Obstructive Pulmonary Disease A Scoping Review | Background and Objective: Current evidence suggests that patients with chronic obstructive pulmonary disease (COPD) should receive influenza and pneumococcal vaccinations. Despite international guidelines recommending vaccination in patients with COPD, many patients remain unvaccinated. Reasons for ... | 6/19/2019 | |
| Resident Impact on Patient amp; Surgeon Satisfaction and Outcomes Evidence for Health System Support for Urology Education | CONCLUSION: Resident coverage of a private practice urology group resulted in no difference in surgical complications and improvement in readmission rates in nonsurgical patients. It resulted in longer OR times but greater satisfaction of faculty, residents and most important, patients. Our data dem... | 6/14/2019 | |
| Intravenous tPA in the treatment of acute stroke related to aortic dissection | A 61-year-old woman with no prior medical illness presented with acute onset stroke symptoms. She had no chest pain at the time of presentation. However, CT angiogram showed an extensive aortic dissection, resulting in hypoperfusion of the right cerebral hemisphere and thus causing stroke symptoms. ... | 6/6/2019 | |
| Senescent cells evade immune clearance via HLA-E-mediated NK and CD8supsup T cell inhibition | Senescent cells accumulate in human tissues during ageing and contribute to age-related pathologies. The mechanisms responsible for their accumulation are unclear. Here we show that senescent dermal fibroblasts express the non-classical MHC molecule HLA-E, which interacts with the inhibitory recepto... | 6/5/2019 | |
| Translabyrinthine Approach for Resection of Vestibular Schwannoma | Objectives This video describes the surgical indications, relevant anatomy, and surgical steps of routine translabyrinthine surgery for gross total resection of sporadic vestibular schwannoma. Design The procedure is presented through a surgical instructional video. Setting The surgery took place at... | 5/31/2019 | |
| Quality of Life in Jugular Paraganglioma Following Radiosurgery | CONCLUSIONS: Patients treated with primary or staged SRS for JP tend to exhibit better swallowing outcomes than those treated with SRS for recurrent JP. However, the majority of overall and disease-specific quality of life measures were not different between groups. Based on the low incidence of new... | 5/29/2019 | |
| Inverted papilloma with multifocal attachment is associated with increased recurrence | CONCLUSION: Primary resection and single-focus attachment of inverted papilloma are associated with lower recurrence rates at 3-year follow-up. | 5/25/2019 | |
| Diagnosis and Endovascular Embolization of a Sacral Spinal Arteriovenous Fistula with Holo-Spinal Venous Drainage | CONCLUSIONS: Selective transarterial catheterization and embolization with n-butyl cyanoacrylate resulted in complete occlusion of the AVF. Clinical improvement was also noted on postprocedural day 1. This case highlights the importance of internal iliac injections as a critical component of spinal ... | 5/24/2019 | |
| Risk Factors for Venous Thromboembolism After Admission for Traumatic Subdural Hematoma at Level I Trauma Center Large Single-Institution Series | CONCLUSIONS: While overall VTE risk is low following tSDH, elderly patients and those with severe injuries requiring prolonged hospitalizations have increased thrombotic risk. Development of tiered VTE prophylaxis regimens based on early postinjury thrombotic risk profiles warrants future study. | 5/21/2019 | |
| Ventricular Dysfunction, Interdependence, and Mechanical Dispersion in Newborn Infants with Congenital Diaphragmatic Hernia | CONCLUSIONS: Global impairment of RV and LV systolic function are present in newborn infants with CDH and are associated with primary left ventricular dysfunction, ventricular interdependence, and MD. | 5/16/2019 | |
| Predictive factors of incomplete aneurysm occlusion after endovascular treatment with the Pipeline embolization device | CONCLUSIONS: Incomplete aneurysm occlusion following placement of a PED was independently associated with age > 70 years, aneurysm diameter ≥ 15 mm, and fusiform morphology. Such predictive factors can be used to guide individualized treatment selection and counseling in patients undergoing cerebrov... | 4/27/2019 | |
| Surgical relevance of pediatric skull base maturation for the far-lateral and extreme-lateral infrajugular transcondylar-transtubercular exposure approaches | CONCLUSIONS: When considering a far-lateral or ELITE approach in pediatric patients, standard OC drilling is likely to be needed due to the relative stability of OC and HGC anatomy during development. The JT significantly increases in size with development, yet is only likely to need to be drilled i... | 4/27/2019 | |
| Race and socioeconomic disparity in treatment and outcome of traumatic cervical spinal cord injury with fracture Nationwide Inpatient Sample database, 1998-2009 | CONCLUSIONS: Despite trending improved outcomes after TCSCIF, LSES, or AA race were more likely to have worse outcomes compared to their counterparts. In addition, LSES, AA, and Hispanic groups were less likely to undergo surgical treatment, suggesting disparities in management and outcome effect. | 4/18/2019 | |
| Hybrid approach to ventricular septal defect enlargement | The need for creation or enlargement of a ventricular septal defect (VSD) is a rare occurrence. It is most frequently required in patients with double-outlet right ventricle who develop restriction of a remote muscular VSD or obstruction of a perimembranous VSD secondary to atrioventricular (AV) val... | 4/16/2019 | |
| Expansile Traumatic Neuroma of the Intratemporal Facial Nerve | Objectives To present a rare case of traumatic facial neuroma involving the geniculate ganglion and review relevant literature. Patient Thirty-year-old man. Intervention Microsurgical resection via combined mastoid-middle fossa approach with great auricular nerve interpositional graft. Main Outcome ... | 4/4/2019 | |
| Development of solitary chemosensory cells in the distal lung after severe influenza injury | H1N1 influenza virus infection induces dramatic and permanent alveolar remodeling mediated by p63^(+) progenitor cell expansion in both mice and some patients with acute respiratory distress syndrome. This persistent lung epithelial dysplasia is accompanied by chronic inflammation, but the driver(s)... | 3/26/2019 | |
| Fungal extracts stimulate solitary chemosensory cell expansion in noninvasive fungal rhinosinusitis | CONCLUSION: Although fungal antigens are known to potentiate immune response through innate cytokines, including IL-25, the early expansion of SCCs in the presence of fungus has not been described. This early event in the pathogenesis of noninvasive fungal rhinosinusitis may represent a target for i... | 3/21/2019 | |
| Analysis of the Essential Oils of Five Artemisia Species and Evaluation of their Cytotoxic and Proapoptotic Effects | BACKGROUND: In this study, the essential oil composition and cytotoxic activities of five Artemisia species were determined. | 3/14/2019 | |
| The Pipeline Embolization Device Changes in Practice and Reduction of Complications in the Treatment of Anterior Circulation Aneurysms in a Multicenter Cohort | CONCLUSION: We report a notable drop in the rate of hemorrhagic and to a lesser extent thromboembolic complications with increased experience with PED in a multicenter cohort. Multiple factors are believed to contribute to this drop, including the evolved interpretation of platelet function testing,... | 3/13/2019 | |
| Understanding the Role of Biofilms and Superantigens in Chronic Rhinosinusitis | PURPOSE OF REVIEW: This review explores recent discoveries in our understanding of how biofilms and superantigens contribute to the pathogenesis of chronic rhinosinusitis (CRS). It also examines clinical implications and novel treatment approaches for biofilm associated CRS. | 3/13/2019 | |
| Asymptomatic radiographic sinonasal inflammation does not affect pituitary surgery outcomes | CONCLUSION: In asymptomatic patients, radiographic evidence of sinonasal inflammation is not associated with increased risk of complications following TSA. | 3/6/2019 | |
| Immunosuppressive mechanisms for stem cell transplant survival in spinal cord injury | Spinal cord injury (SCI) has been associated with a dismal prognosis-recovery is not expected, and the most standard interventions have been temporizing measures that do little to mitigate the extent of damage. While advances in surgical and medical techniques have certainly improved this outlook, l... | 3/6/2019 | |
| A multi-institutional analysis of presentation and outcomes for leptomeningeal disease recurrence after surgical resection and radiosurgery for brain metastases | CONCLUSIONS: Nodular LMD is a distinct pattern of LMD associated with postoperative SRS that is less likely to be symptomatic and has better OS outcomes than classical "sugarcoating" LMD. Although focal RT demonstrated increased second LMD recurrence compared with WBRT, there was no associated OS de... | 3/5/2019 | |
| The centromedian nucleus Anatomy, physiology, and clinical implications | Of all the truncothalamic nuclei, the centromedian-parafascicular nuclei complex (CM-Pf) is the largest and is considered the prototypic thalamic projection system. Located among the caudal intralaminar thalamic nuclei, the CM-Pf been described by Jones as "the forgotten components of the great loop... | 3/5/2019 | |
| Ultrasound-triggered antibiotic release from PEEK clips to prevent spinal fusion infection Initial evaluations | Despite aggressive peri-operative antibiotic treatments, up to 10% of patients undergoing instrumented spinal surgery develop an infection. Like most implant-associated infections, spinal infections persist through colonization and biofilm formation on spinal instrumentation, which can include metal... | 3/4/2019 | |
| Correlation of perioperative risk scores with hospital costs in neurosurgical patients | CONCLUSIONS: Previous work has demonstrated that the ACS NSQIP surgical risk calculator can accurately predict mortality after neurosurgery but is poorly predictive of other potential adverse events and clinical outcomes. However, this study demonstrates that predicted high-risk patients identified ... | 2/17/2019 | |
| Evaluation of cranial base repair techniques utilizing a novel cadaveric CPAP model | CONCLUSION: Different skull base repair techniques have varying ability to withstand CPAP. Both second and third repair techniques performed in a nearly similar fashion with regard to their ability to withstand positive pressure ventilation. | 2/13/2019 | |
| Antiplatelet Medication and Operative Subdural Hematomas A Retrospective Cohort Study Evaluating Reoperation Rates | CONCLUSIONS: Antiplatelet medication was not a significant predictor of reoperation following evacuation of an acute or mixed-density SDH. In patients on antiplatelet medication, preoperative platelet transfusion did not reduce reoperation rates. | 2/9/2019 | |
| Adenoid cystic carcinoma of the sinonasal tract a review of the national cancer database | CONCLUSION: Predictors of survival in SNACC include age, comorbidity status, grade, and stage. Surgery is associated with improved survival and remains the mainstay of therapy, whereas the roles of radiation therapy and chemotherapy require future investigation. | 1/16/2019 | |
| Retained Intrauterine Device IUD Triple Case Report and Review of the Literature | CONCLUSION: Patients in whom uterine perforation and IUD migration are suspected should have appropriate evaluation that includes transvaginal or transabdominal ultrasound or radiographs to confirm the position of the IUD, regardless of whether they are asymptomatic or present with symptoms. It is p... | 1/11/2019 | |
| Broncho-Vaxom OM-85 BV soluble components stimulate sinonasal innate immunity | CONCLUSION: OM-85 BV has ciliostimulatory and immunogenic properties that may be partially responsible for its observed efficacy as a respiratory therapeutic. These responses were NO-dependent and consistent with T2R activation. Further work is necessary to elucidate specific component-receptor sign... | 1/8/2019 | |
| The Role of Free Tissue Transfer in the Management of Chronic Frontal Sinus Osteomyelitis | CONCLUSIONS: Extensive debridement followed by free tissue transfer and antibiotics offers a definitive treatment for complicated, recurrent frontal osteomyelitis. Simultaneous cranioplasty provides immediate protective and aesthetic benefit without complication. Consideration should be given for fr... | 12/15/2018 | |
| Circumferential Stabilization of the Thoracolumbar Junction Via Posterior-Only Approach for the Management of Burst Fractures | CONCLUSION: The transpedicular approach for circumferential reconstruction and stabilization provides an alternative technique for the management of thoracolumbar fractures, having an acceptable risk and the associated lower morbidity of a posterioronly approach. | 12/15/2018 | |
| Whole blood aggregometry prior to Pipeline embolization device treatment of intracranial aneurysms defining an optimal platelet inhibition cutoff value for clopidogrel | CONCLUSIONS: Thromboembolic complications are more common following PED placement in patients who do not respond adequately to clopidogrel. Clopidogrel nonresponders can be identified using pretreatment whole blood aggregometry. The optimal cutoff value to categorize a patient as a clopidogrel nonre... | 12/1/2018 | |
| A cadaveric model for measuring sinonasal continuous positive airway pressure-a proof-of-concept study | CONCLUSION: Our proof-of-concept cadaver model represents a novel approach to measure pressures delivered to the nasal cavity and anterior skull base by CPAP. With further study, it may have broader clinical application to guide the safe postoperative use of CPAP in this population. | 11/16/2018 | |
| Role of Taste Receptors as Sentinels of Innate Immunity in the Upper Airway | Evidence is emerging that shows taste receptors serve functions outside of taste sensation of the tongue. Taste receptors have been found in tissue across the human body, including the gastrointestinal tract, bladder, brain, and airway. These extraoral taste receptors appear to be important in modul... | 10/27/2018 | |
| A Prospective Cohort Study of Postdischarge Opioid Practices After Radical Prostatectomy The ORIOLES Initiative | Opioid pain medications are overprescribed, but few data are available to help in appropriate tailoring of postdischarge opioid prescriptions after surgery. Prior studies are retrospective and based on incomplete responses (<50%) to questionnaires, with small sample sizes for any particular surgery.... | 10/25/2018 | |
| Preoperative embolization of skull base meningiomas A systematic review | Neoadjuvant endovascular embolization of skull base meningiomas may facilitate surgical resection, thereby potentially decreasing operative morbidity. However, due to variation in the reported efficacy and complication rates, the utility of embolization remains incompletely defined. The aim of this ... | 10/4/2018 | |
| Morphology of intramural ventricular septal defects Clinical imaging and autopsy correlation | An intramural ventricular septal defect (IVSD) is a type of interventricular communication that can occur following biventricular repair of a conotruncal malformation. There have been no previous reports depicting the actual pathologic anatomy of this defect. We describe two cases of IVSDs with thei... | 10/2/2018 | |
| Sentinels at the wall epithelial-derived cytokines serve as triggers of upper airway type 2 inflammation | Recent evidence has demonstrated an expanding role of respiratory epithelial cells in immune surveillance and modulation. Studies have been focusing on the earliest events that link epithelial injury to downstream inflammatory responses. Cytokines produced by and released from respiratory epithelial... | 9/28/2018 | |
| Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen-Specific Challenge | CONCLUSION: Zostavax vaccination does not alter the abundance of cutaneous resident memory T cells but instead increases the recruitment of VZV-specific T cells from the blood and enhances T-cell activation, particularly cells of the CD8+ subset, in the skin after VZV antigen challenge. | 9/25/2018 | |
| Fluoroscopy-Assisted Transnasal Onyx Occlusion of the Eustachian Tube for Lateral Skull Base Cerebrospinal Fluid Leak Repair | Objectives To describe transnasal Eustachian tube (ET) occlusion with a liquid embolic solution for lateral skull base cerebrospinal fluid (CSF) leaks. Design A lateral skull base CSF fistula model was developed by the authors using fresh cadaveric heads. Using a transtympanic needle, regulated pres... | 9/14/2018 | |
| Superior Canal Dehiscence Involving the Superior Petrosal Sinus A Novel Classification Scheme | CONCLUSIONS: SSCD involving the SPS represents a small but distinct subset of SSCD cases. This scenario can create a unique set of symptoms and surgical challenges when intervention is sought. Clinical findings and considerations for surgical intervention are provided to facilitate effective diagnos... | 9/11/2018 | |
| Novel Use of a Nurse-Led Telemedicine Team in Acute Stroke A Retrospective Review of the Impact on a Regional Health Care System | CONCLUSION: In an acute stroke telemedicine system, implementation of a local nurse-led "stroke responder" system resulted in significantly decreased acute stroke metrics for a community hospital within a regional hospital system. | 9/10/2018 | |
| Early Postnatal Ventricular Dysfunction Is Associated with Disease Severity in Patients with Congenital Diaphragmatic Hernia | CONCLUSIONS: RV and LV function are impaired in the transitional period in infants with CDH. Early LV systolic function correlates with prenatal and postnatal markers of clinical disease severity and may be an important determinant of disease severity and therapeutic target in CDH. These findings su... | 9/10/2018 | |
| Chordoid Glioma with Psychosis Case Report | CONCLUSION: A chordoid glioma is a rare neoplasm that, in 2000, was incorporated into the World Health Organization (WHO) classification of central nervous system tumors. Due to its rarity, it is seldom considered in the differential diagnosis of suprasellar masses. Moreover, its unusual presentatio... | 9/7/2018 | |
| Impact of Variation of Corticosteroid Dose, Injection Site, and Multiple Injections on Blood Glucose Measurement in Diabetic Patients | CONCLUSIONS: Patients receiving corticosteroid injections in the upper extremity did not experience significant increases in blood glucose whereas those undergoing knee corticosteroid injections demonstrated elevated blood glucose levels. Because poorer glucose control was associated with greater el... | 8/6/2018 | |
| An Incidental Finding of Ecchordosis Physaliphora in a Case of Abducens Nerve Palsy Case Report | Ecchordosis physaliphora (EP) is a rare non-malignant mass that originates from remains of the notochord and is typically asymptomatic. A 42-year-old man presented with sudden onset of painless horizontal diplopia and his neurological exam showed sixth cranial nerve palsy. Magnetic resonance imaging... | 7/26/2018 | |
| Pembrolizumab monotherapy versus chemotherapy for treatment of advanced urothelial carcinoma with disease progression during or following platinum-containing chemotherapy A Cochrane Rapid Review | BACKGROUND: The use of systemic immunotherapy targets is emerging as an important treatment option for metastatic urothelial carcinoma, particularly for patients who cannot tolerate or who fail cisplatin-based chemotherapy. One such target is the inhibition of the checkpoint protein programmed cell ... | 7/24/2018 | |
| Salvage Radiosurgery After Subtotal Resection for Catecholamine-secreting Jugular Paragangliomas Report of Two Cases and Review of the Literature | CONCLUSIONS: Radiosurgery can be used in salvage treatment of catecholamine-secreting JP, providing durable tumor control and resolution of catecholamine excess. For patients with large catecholamine-secreting JP and normal lower cranial nerve function, aggressive nerve-sparing subtotal resection wi... | 7/18/2018 | |
| Newer-Generation Ultrathin Strut Drug-Eluting Stents Versus Older Second-Generation Thicker Strut Drug-Eluting Stents for Coronary Artery Disease | CONCLUSIONS: In patients undergoing percutaneous coronary intervention, newer-generation ultrathin strut DES further improve 1-year clinical outcomes in comparison with contemporary thicker strut second-generation DES. | 6/28/2018 | |
| Use of 4D Computer Tomographic Angiography to Accurately Identify Distal Internal Carotid Artery Occlusions and Pseudo-Occlusions Technical Note | CONCLUSION: 4D CTA may be a more effective noninvasive imaging technique than traditional CTA to detect intracranial carotid artery occlusions and carotid artery pseudo-occlusions. Accurate, rapid, and noninvasive diagnosis of carotid artery lesions may help tailor and expedite endovascular interven... | 6/21/2018 | |
| Defining outcomes following congenital diaphragmatic hernia using standardised clinical assessment and management plan SCAMP methodology within the CDH EURO consortium | Treatment modalities for neonates born with congenital diaphragmatic hernia (CDH) have greatly improved in recent times with a concomitant increase in survival. In 2008, CDH EURO consortium, a collaboration of a large volume of CDH centers in Western Europe, was established with a goal to standardiz... | 6/20/2018 | |
| A First-in-Human, Phase I Study of Neural Stem Cell Transplantation for Chronic Spinal Cord Injury | We tested the feasibility and safety of human-spinal-cord-derived neural stem cell (NSI-566) transplantation for the treatment of chronic spinal cord injury (SCI). In this clinical trial, four subjects with T2-T12 SCI received treatment consisting of removal of spinal instrumentation, laminectomy, a... | 6/3/2018 | |
| Ipilimumab-induced Adenohypophysitis and Orbital Apex Syndrome Importance of Early Diagnosis and Management | Ipilimumab is a novel anti-melanoma agent known to infrequently cause multi-organ autoimmunity. We report a case of pituitary hypophysitis and orbital inflammation followed by an orbital apex syndrome. A 64-year-old woman with a history of skin melanoma, receiving ipilimumab treatment, was seen for ... | 5/26/2018 | |
| Antiplatelet Medication Reversal Strategies in Operative Intracranial Hemorrhage A Survey of Practicing Neurosurgeons | CONCLUSIONS: When patients on antiplatelet medication present with operative intracranial hemorrhage, the majority of neurosurgeons do not perform qualitative platelet testing. Antiplatelet reversal strategies are significantly influenced by the antiplatelet therapy with more aggressive reversal str... | 5/22/2018 | |
| Solitary chemosensory cells are a primary epithelial source of IL-25 in patients with chronic rhinosinusitis with nasal polyps | CONCLUSIONS: Inflammatory sinus polyps but not adjacent turbinate tissue show expansion of the SCC population, which is the source of epithelial IL-25. | 5/21/2018 | |
| Prognostic Significance of Post-Operative Morbidity Severity Score After Potentially Curative D2 Gastrectomy for Carcinoma | CONCLUSION: Post-operative CDSC was an important independent prognostic factor after potentially curative gastrectomy for carcinoma associated with both DFS and OS. Prehabilitation strategies to minimize complications are warranted. | 5/17/2018 | |
| Solitary chemosensory cells producing interleukin-25 and group-2 innate lymphoid cells are enriched in chronic rhinosinusitis with nasal polyps | CONCLUSION: These data support SCC and ILC2 expansion as well as increased IL-25 production in nasal polyps and may represent early events in the pathogenesis of CRSwNP. IL-13 stimulates proliferation of SCC in a feed-forward loop, a process that is steroid-sensitive. | 5/10/2018 | |
| Minimally Invasive Transforaminal Versus Direct Lateral Lumbar Interbody Fusion Effect on Return to Work, Narcotic Use, and Quality of life | CONCLUSIONS: Both MIS TLIF and DLIF provide long-term improvement in pain andfunctional outcomes, with an overall reduction in postoperative narcotic requirement. However, there was a significantly longer time to return to work and a greater incidence of reoperation in the TLIF cohort compared with ... | 5/9/2018 | |
| Pipeline embolization of posterior circulation aneurysms a multicenter study of 131 aneurysms | CONCLUSIONS: In the largest series to date, fusiform aneurysms were found to have the lowest occlusion rate and the highest frequency of major complications. Dissecting aneurysms, frequently treated in the setting of subarachnoid hemorrhage, occluded most often and had a low complication rate. Saccu... | 5/5/2018 | |
| PHASES score applied to a prospective cohort of aneurysmal subarachnoid hemorrhage patients | The treatment of unruptured intracranial aneurysms remains controversial. The PHASES score was developed to predict the 5-year risk of aneurysm rupture. We have assigned PHASES scores to a cohort of aneurysmal subarachnoid hemorrhage (aSAH) patients to assess the distribution of scores and its abili... | 4/25/2018 | |
| Long-term tumor control following stereotactic radiosurgery for jugular paraganglioma using 3D volumetric segmentation | CONCLUSIONS: SRS achieves excellent long-term tumor control for JP without a high risk for new or worsened cranial neuropathy when used in primary, combined modality, or recurrent settings. Long-term follow-up is critical due to the potential for late radiographic progression (i.e., more than 10 yea... | 4/14/2018 | |
| Unmasking the borderline coarctation the utility of isoproterenol in the paediatric cardiac catheterisation laboratory | CONCLUSIONS: Isoproterenol can be a useful tool to assess the significance of a coarctation and the effectiveness of an intervention. Percutaneous interventions can effectively reduce the gradients elicited by isoproterenol. | 3/15/2018 | |
| Flow Diversion for the Treatment of Basilar Apex Aneurysms | CONCLUSION: Flow diversion for the treatment of basilar apex aneurysms results in acceptable occlusion rates in highly selected cases. Both primary flow diversion and rescue after failed clipping or coiling resulted in a modified Rankin Scale score that was either equal or better than at presentatio... | 3/13/2018 | |
| Neck Remnants and the Risk of Aneurysm Rupture After Endovascular Treatment With Coiling or Stent-Assisted Coiling Much Ado About Nothing | CONCLUSION: We found that unruptured aneurysms with residual necks following endovascular treatment posed a very low risk of rupture (0.6%). However, patients presenting with ruptured aneurysms had a higher risk of rerupture from a neck remnant (3.4%). These results highlight the importance of achie... | 3/13/2018 | |
| Disease burden and conditioning regimens in ASCT1221, a randomized phase II trial in children with juvenile myelomonocytic leukemia A Childrens Oncology Group study | CONCLUSIONS: The regimen of Bu-Flu is inadequate to provide disease control in patients with JMML who present to HCT with large burdens of disease. Advances in molecular testing may allow better characterization of biologic risk, pre-HCT responses to chemotherapy, and post-HCT management. | 3/13/2018 | |
| Radiographic and Neurological Outcome After Surgical Treatment of Traumatic Fractures of the Ankylotic Thoracic Spine A Retrospective Case Series | CONCLUSION: Presenting fracture alignment does not significantly correlate with pre- or postoperative neurological status. Early posterior stabilization preserved neurological function, with neurological recovery occurring in a portion of individuals. | 2/21/2018 | |
| Endovascular Mechanical Thrombectomy for Acute Ischemic Stroke Under General Anesthesia Versus Conscious Sedation A Systematic Review and Meta-Analysis | CONCLUSIONS: The use of either GA or CS during EMT for patients with anterior circulation acute ELVO does not yield significantly different rates of functional independence at 3 months. | 1/23/2018 | |
| Trainee Update, Winter 2017 | The Specialist Advisory Committee (SAC) of June 2017 discussed the sign off of procedural competences relating to Sengstaken-Blakemore tube insertion and transvenous cardiac pacing and the application for chief registrar roles. | 1/5/2018 | |
| Web-Based Patient Experience Surveys to Enhance Response Rates subA Prospective Studysub | CONCLUSIONS: We recommend that ambulatory clinics use Web-based technology to administer CAHPS clinician and group surveys, using both e-mail and in-clinic distribution to enhance the response rate. | 12/19/2017 | |
| Postoperative radiosurgery for the treatment of metastatic brain tumor Evaluation of local failure and leptomeningeal disease | In patients undergoing surgical resection of a metastatic brain tumor, whole brain radiation therapy reduces the risk of recurrence and neurologic death. Focal radiation has the potential to mitigate neurocognitive side effects. We present an institutional experience of postoperative radiosurgery fo... | 12/18/2017 | |
| Prognostic Significance of Serum Inflammatory Markers in Gastric Cancer | CONCLUSION: mGPS is an important and only SIR-related prognostic biomarker independently associated with both DFS and OS in gastric cancer. | 12/14/2017 | |
| Bone Morphogenetic Protein Usage in Anterior Lumbar Interbody Fusion What Else Can Go Wrong | CONCLUSION: Caution must be exercised while using BMPs because of inadvertent complications. | 12/13/2017 | |
| Coated-Platelet Trends Predict Short-Term Clinical OutcomeAfter Subarachnoid Hemorrhage | Aneurysmal subarachnoid hemorrhage (aSAH) is associated with high socio-economic burden. Prothrombotic states of early brain injury (EBI) and delayed cerebral ischemia (DCI) after aSAH determine morbidity and mortality. To understand how activated platelets might contribute to such prothrombotic sta... | 12/11/2017 | |
| Neurostimulant use is associated with improved survival in comatose patients after cardiac arrest regardless of electroencephalographic substrate | CONCLUSION: EEG patterns described as ominous after cardiac arrest did not preclude survival or awakening after neurostimulant administration. These data are limited by their observational nature and potential for selection bias, but suggest that EEG patterns alone should not affect consideration of... | 12/10/2017 | |
| Mood-Stabilizing Anticonvulsants, Spina Bifida, and Folate Supplementation Commentary | PURPOSE/BACKGROUND: High risks of neural tube defects and other teratogenic effects are associated with exposure in early pregnancy to some anticonvulsants, including in women with bipolar disorder. | 12/8/2017 | |
| Hearing Outcomes After Stereotactic Radiosurgery for Jugular Paraganglioma | CONCLUSION: The short- and intermediate-term risk of progression to nonserviceable hearing following SRS for JP is low. Data regarding the impact of cochlear dose from the vestibular schwannoma literature should not be freely applied to JP, since the impact of SRS parameters on hearing preservation ... | 12/2/2017 | |
| Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein MAP kinase-induced inflammation | CONCLUSION: Excessive inflammation in the skin early after antigen challenge retards antigen-specific immunity. However, this can be reversed by inhibition of inflammatory cytokine production that can be used to promote vaccine efficacy and the treatment of infections and malignancy during aging. | 11/21/2017 | |
| The medial vestibular nuclei, a vulnerable target in thiamine deficiency | CONCLUSION: This single case study provides clinical-imaging correlation for symmetric MVN compromise in thiamine deficiency, its effect on the VOR gain and the favorable response to thiamine and diet replacement when identified early. | 11/17/2017 | |
| Traumatic brain injury and intracranial hemorrhage-induced cerebral vasospasm a systematic review | OBJECTIVE Little is known regarding the natural history of posttraumatic vasospasm. The authors review the pathophysiology of posttraumatic vasospasm (PTV), its associated risk factors, the efficacy of the technologies used to detect PTV, and the management/treatment options available today. METHODS... | 11/2/2017 | |
| The role of endothelial nitric oxide synthase -786 TC polymorphism in cardiac instability following aneurysmal subarachnoid hemorrhage | CONCLUSIONS: The C allele of the eNOS SNP -786 T/C was independently associated with an increased risk for cardiac instability following aSAH. Cardiac instability itself was a risk factor for an unfavorable functional outcome upon discharge from the hospital. | 10/29/2017 | |
| Society for Acute Medicine Trainee Update, Autumn 2017 | Tehmeena Khan has replaced Sanjay Krishnamoorthy as a Trainee Representative for SAM. We would like to thank Sanjay for all his hard work and contribution during his tenure as Rep. Tehmeena is a final year trainee from North East & Central London. Tehmeena's specialist skills are Leadership, Managem... | 10/27/2017 | |
| Race as a predictor of postoperative hospital readmission after spine surgery | Hospital readmission after surgery results in a substantial economic burden, and several recent studies have investigated the impact of race and ethnicity on hospital readmission rates, with the goal to identify hospitals and patients with high readmission risk. This single-institution, retrospectiv... | 9/13/2017 | |
| Association of cystathionine beta-synthase polymorphisms and aneurysmal subarachnoid hemorrhage | OBJECTIVE Cystathionine β-synthase (CBS) is involved in homocysteine and hydrogen sulfide (H(2)S) metabolism. Both products have been implicated in the pathophysiology of cerebrovascular diseases. The impact of CBS polymorphisms on aneurysmal subarachnoid hemorrhage (aSAH) and its clinical sequelae ... | 8/5/2017 | |
| Rural Rotations at Core Rarefied Exposure or Real Experience | CONCLUSION: CST rotations including rGHs produced a different spectrum of training experience compared with uGH rotations but overall primary outcomes were similar. | 7/17/2017 | |
| Electrochemical and structural characterization of Azotobacter vinelandii flavodoxin II | Azotobacter vinelandii flavodoxin II serves as a physiological reductant of nitrogenase, the enzyme system mediating biological nitrogen fixation. Wildtype A. vinelandii flavodoxin II was electrochemically and crystallographically characterized to better understand the molecular basis for this funct... | 7/16/2017 | |
| Bisphosphonates and Intermittent Parathyroid Hormones Effect on Human Spinal Fusion A Systematic Review of the Literature | There has been a conscious effort to address osteoporosis in the aging population. As bisphosphonate and intermittent parathyroid hormone (PTH) therapy become more widely prescribed to treat osteoporosis, it is important to understand their effects on other physiologic processes, particularly the im... | 7/4/2017 | |
| The Clinical Correlations between Diabetes, Cigarette Smoking and Obesity on Intervertebral Degenerative Disc Disease of the Lumbar Spine | CONCLUSIONS: Diabetes, obesity and cigarette smoking each are significantly associated with an increased diagnosis of lumbar degenerative disc disease. The combination of smoking and obesity had a synergistic effect on increased rates of lumbar degenerative disc disease. Patient education and preven... | 7/4/2017 | |
| Cardiac dysfunction in congenital diaphragmatic hernia Pathophysiology, clinical assessment, and management | Cardiac dysfunction is an important consequence of pulmonary hypertension in congenital diaphragmatic hernia and a determinant of disease severity. Increased afterload leads to right ventricular dilatation and diastolic dysfunction. Septal displacement and dysfunction impair left ventricular functio... | 6/24/2017 | |
| Vertebroplasty for vertebral compression fractures Placebo or effective | Vertebral compression fractures (VCFs) are a major cause of pain and disability. Here, we reviewed six randomized control trials (RCTs) focusing on the efficacy vs. placebo effect of vertebroplasty (VP) for symptomatic VCF. Four RCTs involved a nonsurgically treated control group. Two RCTs compared ... | 6/14/2017 | |
| Association of Plasminogen Activator Inhibitor 1 SERPINE1 Polymorphisms and Aneurysmal Subarachnoid Hemorrhage | CONCLUSIONS: SERPINE1 gene polymorphisms were associated with delayed cerebral ischemia and functional outcome after aSAH. These associations may arise from alterations of plasminogen activator inhibitor 1 levels. | 6/11/2017 | |
| The Use of Single Stent-Assisted Coiling in Treatment of Bifurcation Aneurysms A Multicenter Cohort Study With Proposal of a Scoring System to Predict Complete Occlusion | CONCLUSION: The treatment of bifurcation aneurysm using single stent technique for stent-assisted coiling is safe and effective. Complete occlusion or remnant neck occlusion was achieved in 90.6% of cases. Class III aneurysms can be effectively treated using a single stent, while class I may require... | 6/9/2017 | |
| Pipeline Embolization Device in Treatment of 50 Unruptured Large and Giant Aneurysms | CONCLUSIONS: The use of PED for the treatment of large and giant intracranial aneurysms is associated with good occlusion rates, but also a greater complication rate compared to aneurysms of smaller size. There was no significant difference in occlusion rate based on aneurysm shape or size, number o... | 6/5/2017 | |
| Comparison of Stent-Assisted Coil Embolization and the Pipeline Embolization Device for Endovascular Treatment of Ophthalmic Segment Aneurysms A Multicenter Cohort Study | CONCLUSION: Stent-coiling and the PED were equally effective for treating OSAs. There were no significant differences in terms of procedural complications, angiographic, functional, and visual outcomes. PED may be more favorable for multiple adjacent OSAs. | 6/1/2017 | |
| Associations between endothelin polymorphisms and aneurysmal subarachnoid hemorrhage, clinical vasospasm, delayed cerebral ischemia, and functional outcome | OBJECTIVE Endothelin-1, a potent vasoconstrictor, and its receptors may be involved in the pathogenesis of aneurysmal subarachnoid hemorrhage (aSAH), clinical vasospasm, delayed cerebral ischemia (DCI), and functional outcome following aSAH. In the present study, common endothelin single nucleotide ... | 5/27/2017 | |
| Hearing Preservation in Pediatric Cochlear Implantation | CONCLUSIONS: Varying levels of hearing preservation with conventional length electrodes can be achieved in most pediatric subjects. In the current study, 82% of patients maintained detectable hearing thresholds and 65% maintained functional low-frequency acoustic hearing. These data may be used to g... | 5/25/2017 | |
| High throughput RNA sequencing utility for diagnosis and prognosis in colon diseases | RNA sequencing is the use of high throughput next generation sequencing technology to survey, characterize, and quantify the transcriptome of a genome. RNA sequencing has been used to analyze the pathogenesis of several malignancies such melanoma, lung cancer, and colorectal cancer. RNA sequencing c... | 5/20/2017 | |
| Is there a July effect in pediatric neurosurgery | CONCLUSION: For the majority of morbidity and mortality events, no significant difference was found in occurrence rates between the first and last quarters. | 5/15/2017 | |
| Virtual Mapping of the Frontal Recess Guiding Safe and Efficient Frontal Sinus Surgery | Objective To define relationships between the frontal sinus opening, ostia of other frontal recess cells, and endoscopic landmarks and to develop a clinically useful framework to guide frontal sinus surgery. Study Design Retrospective review. Setting Tertiary care academic referral center. Methods A... | 4/19/2017 | |
| The use of a novel perfusion-based cadaveric simulation model with cerebrospinal fluid reconstitution comparing dural repair techniques a pilot study | CONCLUSIONS: We described the feasibility of using a novel cadaveric model for both the study and training of watertight dural closure techniques. 6-0 Prolene was observed to be superior to 4-0 Nurolon for watertight dural closure without a hydrogel sealant. The use of a hydrogel sealant significant... | 4/17/2017 | |
| Endothelin polymorphisms as a risk factor for cerebral aneurysm rebleeding following aneurysmal subarachnoid hemorrhage | CONCLUSION: Aneurysm rebleeding following presentation with aSAH was independently associated with the TT genotype of the EDN1 G/T SNP. All patients with acute spontaneous aneurysm rebleeding suffered a poor functional outcome at last follow up. | 4/17/2017 | |
| Use of Platelet Function Testing Before Pipeline Embolization Device Placement A Multicenter Cohort Study | CONCLUSIONS: Clopidogrel nonresponders experienced a significantly higher rate of thromboembolic complications when compared with clopidogrel responders. However, this risk seems to be mitigated in nonresponders who were switched to ticagrelor or received a clopidogrel boost within 24 hours pre-proc... | 4/16/2017 | |
| Dopaminergic control of anxiety in young and aged zebrafish | Changes in the expression of the dopamine transporter (DAT), or the sensitivity of dopamine receptors, are associated with aging and substance abuse and may underlie some of the symptoms common to both conditions. In this study, we explored the role of the dopaminergic system in the anxiogenic effec... | 4/15/2017 | |
| Blunt Traumatic Extracranial Cerebrovascular Injury and Ischemic Stroke | BACKGROUND: Ischemic stroke occurs in a significant subset of patients with blunt traumatic cerebrovascular injury (TCVI). The patients are victims of motor vehicle crashes, assaults or other high-energy collisions, and suffer ischemic stroke due to injury to the extracranial carotid or vertebral ar... | 4/12/2017 | |
| Back Muscle Morphometry Effects on Outcomes of Spine Surgery | CONCLUSION: With reduction in surgical complications and improvement in postoperative functional outcomes, back muscle morphometry ought to be included in the preoperative surgical planning as a predictor of outcomes. | 4/4/2017 | |
| Superior episodic memory in inconsistent-handers a replication and extension using fNIRS | A large body of evidence supports the existence of a robust handedness difference in episodic memory retrieval, with inconsistent-handedness being associated with superior memory across a wide variety of paradigms, including superior retrieval of lab-based and real world memories. Despite superior e... | 4/1/2017 | |
| Bilateral Labyrinthine and Internal Auditory Canal Enhancement in an Infant With Severe Labyrinthine Dysplasia A Previously Unreported Phenomenon | CONCLUSION: We report a novel presentation and imaging findings of congenital bilateral profound sensorineural hearing loss in a patient with nodular internal auditory canal and labyrinthine enhancement and coexisting inner ear dysplasia. Despite the multiple radiologic abnormalities, the patient ha... | 3/28/2017 | |
| Associations of Endothelin Polymorphisms and Aneurysm Size at Time of Rupture | CONCLUSIONS: The EDNRA SNP rs5335 was independently associated with aneurysms ≥7 mm in size at the time of rupture. Patients with cerebral aneurysms also carrying the G allele of EDNRA SNP rs5335 may develop larger aneurysms before rupture. | 3/22/2017 | |
| Oncolytic Virotherapy for the Treatment of Malignant Glioma | Malignant glioma is the most common primary brain tumor and carries a grim prognosis, with a median survival of just over 14 months. Given the poor outcomes with standard-of-care treatments, novel treatment strategies are needed. The concept of virotherapy for the treatment of malignant tumors dates... | 3/8/2017 | |
| Endothelial Nitric Oxide Synthase Polymorphism Is Associated with Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage | CONCLUSIONS: The present study is the first to demonstrate that the C allele of the eNOS SNP 786 T->C rs2070744 is independently associated with an increased risk for delayed cerebral ischemia following aSAH. | 3/4/2017 | |
| Ischemic Stroke After Treatment of Intraprocedural Thrombosis During Stent-Assisted Coiling and Flow Diversion | CONCLUSIONS: Current protocols for treatment of intraprocedural thrombosis associated with placement of intra-arterial devices were effective in preventing ischemic stroke in ≈80% of cases. Current smoking was the only independent predictor of ischemic stroke. | 3/2/2017 | |
| Impact of High-Mobility Group Box 1 Polymorphism on Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage | CONCLUSIONS: The minor allele G of rs2249825 was associated with an increased risk for DCI, or cerebral infarction, after aSAH. This finding may be attributable to an increased HMGB1 protein expression in these patients. | 2/13/2017 | |
| Impact of Timing of Intervention Among 397 Consecutively Treated Brainstem Cavernous Malformations | CONCLUSIONS: Although BSCM surgery is associated with significant perioperative morbidity and mortality, favorable long-term hemorrhage rates and symptom resolution can be achieved in a carefully selected group of patients. Overall, patients treated acutely, within 6 weeks, benefited the most from s... | 2/11/2017 |
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