Clinical Trials
Orlando Health Cancer Institute participates in clinical trials, testing and evaluating the latest therapies, treatments, screening and diagnostic tools for prostate cancer. Trials involve collaboration across multiple departments, with researchers involved in design, testing and analysis of these studies. Trials can offer our patients early access to promising cancer-fighting options.
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A Phase II Study of Ipilimumab, Cabozantinib, and Nivolumab in Rare Genitourinary Cancers (ICONIC) +
A Phase II Study of Ipilimumab, Cabozantinib, and Nivolumab in Rare Genitourinary Cancers (ICONIC)
Protocol No: ICONIC-A031702
Age Group: Adult
Disease Sites: Kidney, Other Male Genital, Other Urinary, Prostate, Urinary Bladder
NCT Id: NCT03866382
Phase: II
Principal Investigators: Hatem Hassanein, MD
Objective
This study tests the combination of ipilimumab, nivolumab, and cabozantinib in patients with rare genitourinary cancers, measuring how many patients respond to the treatment based on tumor shrinkage or disappearance using RECIST 1.1 criteria.
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A Phase III Clinical Trial Evaluating De-Escalation of Breast Radiation for Conservative Treatment of Stage I, Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer +
A Phase III Clinical Trial Evaluating De-Escalation of Breast Radiation for Conservative Treatment of Stage I, Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer
Protocol No: NRG-BR007
Age Group: Adult
Disease Sites: Breast
NCT Id: NCT04852887
Phase: III
Principal Investigators: Patrick Kelly, MD
Eligibility Document -
Attachment Id: 6853
File Name: NRG-BR007_Subject Eligibility _Screening Checklist_V2_08Nov2024 (002).docx
URL:
Objective
This study is for woman with early-stage, hormone-sensitive breast cancer. It's testing if skipping radiation after surgery is just as safe as getting radiation, when patients are also on hormone therapy.
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Phase III Prospective Randomized Trial of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed by Concurrent Mediastinal Chemoradiation for Locally Advanced Non-Small Cell Lung Cancer +
Phase III Prospective Randomized Trial of Primary Lung Tumor Stereotactic Body Radiation Therapy Followed by Concurrent Mediastinal Chemoradiation for Locally Advanced Non-Small Cell Lung Cancer
Protocol No: NRG-LU008
Age Group: Adult
Disease Sites: Lung
NCT Id: NCT05624996
Phase: III
Principal Investigators: Justin Rineer, MD
Objective
This study is comparing two types of radiation therapy, both given with chemotherapy, to see which helps patients with inoperable stage II IIIC non-small cell lung cancer live longer and stay free from cancer progression.
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Randomized Phase II/III Trial of Adjuvant Radiation Therapy With Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck +
Randomized Phase II/III Trial of Adjuvant Radiation Therapy With Cisplatin, Docetaxel-Cetuximab, or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck
Protocol No: RTOG-1216
Age Group: Adult
Disease Sites: Esophagus, Eye and Orbit, Larynx, Lip, Oral Cavity and Pharynx
NCT Id: NCT01810913
Phase: II/III
Principal Investigators: Rafael Manon, MD
Eligibility Document -
Attachment Id: 7714
File Name: RTOG 1216 Eligibility Final.docx
URL:
Objective
This study is testing which treatment works best after surgery for certain types of head and neck cancer. All patients receive radiation, but the study compares three options: radiation with cisplatin, radiation with docetaxel and cetuximab, or radiation with cisplatin and atezolizumab. The goal is to find out which option helps people live longer and keeps the cancer from coming back.
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SpaceIT Hydrogel System for Perirectal Spacing in Subjects with Low to Intermediate Risk Prostate Cancer Undergoing External Beam Radiotherapy (EBRT) +
SpaceIT Hydrogel System for Perirectal Spacing in Subjects with Low to Intermediate Risk Prostate Cancer Undergoing External Beam Radiotherapy (EBRT)
Protocol No: U0755
Age Group: Adult
Disease Sites: Prostate
NCT Id: NCT06451614
Phase: N/A
Principal Investigators: Akash Nanda, MD
Eligibility Document -
Attachment Id: 11457
File Name: U0755 (HYDROSPACE) Subject Eligibility _Screening Checklist_Version1.0_11Apr2025.docx
URL:
Objective
This study is testing a hydrogel device that helps protect the rectum during radiation therapy for prostate cancer. It creates space between the prostate and rectum to reduce radiation exposure and help prevent side effects.
Request an Appointment
If you have been diagnosed with prostate cancer, request an appointment or second opinion consultation with one of our prostate cancer experts. We are here to answer your questions and provide our state-of-art treatment options that best work for you.
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Monday, January 26, 2026 10:19 PM
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