Journals and Research

Research and education are foundational to the mission of Orlando Health and our Cancer Institute. As frequent contributors to leading publications, our physicians share their research and clinical insights with a national and international community of colleagues.

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Author(s) Title Description Publish Date
Evgenia Gurevich, Daniel Landau Pharmacological Management of Atypical Hemolytic Uremic Syndrome in Pediatric Patients: Current and Future Atypical hemolytic uremic syndrome is a thrombotic microangiopathy characterized by hemolysis, thrombocytopenia, and acute kidney injury, usually caused by alternative complement system overactivation due to pathogenic genetic variants or antibodies to components or regulatory factors in this pathwa... 1/13/2023
Jason Chesney, Karl D Lewis, Harriet Kluger, Omid Hamid, Eric Whitman, Sajeve Thomas, Martin Wermke, Mike Cusnir, Evidio Domingo-Musibay, Giao Q Phan, John M Kirkwood, Jessica C Hassel, Marlana Orloff, James Larkin, Jeffrey Weber, Andrew J S Furness, Nikhil I Khushalani, Theresa Medina, Michael E Egger, Friedrich Graf Finckenstein, Madan Jagasia, Parameswaran Hari, Giri Sulur, Wen Shi, Xiao Wu, Amod Sarnaik Efficacy and safety of lifileucel, a one-time autologous tumor-infiltrating lymphocyte (TIL) cell therapy, in patients with advanced melanoma after progression on immune checkpoint inhibitors and targeted therapies: pooled analysis of consecutive cohorts of the C-144-01 study CONCLUSIONS: Investigational lifileucel demonstrated clinically meaningful activity in heavily pretreated patients with advanced melanoma and high tumor burden. Durable responses and a favorable safety profile support the potential benefit of one-time lifileucel TIL cell therapy in patients with lim... 1/5/2023
Meredith Elana Giuliani, Nishin A Bhadkamkar, Eleni Giannopoulos, Sam Lubner, Jennifer Tseng, Michal Tibbits, Jamie H Von Roenn Advancing the Clinician Educator Career Pathway in Oncology CONCLUSION: Oncology PDs/APDs and fellows perceive the CE to be a viable career track. Greater advocacy efforts are needed to raise awareness about this career path. 12/19/2022
Jared A Shenson, Mark E Zafereo, Mark Lee, Kevin J Contrera, Lei Feng, Mongkol Boonsripitayanon, Neil Gross, Ryan Goepfert, Anastasios Maniakas, Jennifer Rui Wang, Libby Grubbs, Ara Vaporciyan, Wayne Hofstetter, Stephen Swisher, Reza Mehran, David Rice, Boris Sepesi, Mara Antonoff, Maria Cabanillas, Naifa Busaidy, Ramona Dadu, Natalie L Silver Clinical outcomes of combined cervical and transthoracic surgical approaches in patients with advanced thyroid cancer CONCLUSIONS: Combined transcervical and transthoracic surgery for advanced thyroid cancer can be performed without mortality and with acceptable morbidity. 12/16/2022
Luis J Herrera, Lana Y Schumacher, Matthew G Hartwig, Charles T Bakhos, Rishindra M Reddy, Eric Vallières, Michael S Kent Pulmonary Open, Robotic, and Thoracoscopic Lobectomy study: Outcomes and risk factors of conversion during minimally invasive lobectomy CONCLUSIONS: Converted minimally invasive lobectomies were not associated with worse perioperative mortality compared with open lobectomy. Compared with VATS lobectomy, RL is associated with a lower probability of conversion in this propensity-score matched cohort study. 12/12/2022
Mohammad Abu-Abaa, Ghassan Dawood, Hassaan Arshad, Omar Jumaah, Daniel Landau A Possible Case of Autoimmune Encephalitis After mRNA COVID-19 Booster Vaccine: A Case Report As the use of COVID-19 vaccines gains more prevalence, rare and uncommon side effects are reported in the medical literature. This is a case report of a 75-year-old male patient who presented on the second day after receiving the Moderna Bivalent mRNA COVID-19 booster vaccine with abrupt onset behav... 12/8/2022
Sam Z Thalji, Cecilia G Ethun, Susan Tsai, T Clark Gamblin, Callisia N Clarke, Meena Bedi, David King, John LoGiudice, George Poultsides, Valerie P Grignol, Jennifer Tseng, Konstantinos Votanopoulos, Ryan C Fields, Kenneth Cardona, Harveshp Mogal Outcomes of plastic surgical reconstruction in extremity and truncal soft tissue sarcoma:Â Results from the US Sarcoma Collaborative CONCLUSION: Patients with ETSTS undergoing resection with PSR experienced acceptable rates of complications and a higher rate of negative margins, which were associated with improved LRRFS and OS. High tumor grade and neoadjuvant radiation were associated with requirement of PSR. 12/8/2022
Siri H Strand, Belén Rivero-Gutiérrez, Kathleen E Houlahan, Jose A Seoane, Lorraine M King, Tyler Risom, Lunden A Simpson, Sujay Vennam, Aziz Khan, Luis Cisneros, Timothy Hardman, Bryan Harmon, Fergus Couch, Kristalyn Gallagher, Mark Kilgore, Shi Wei, Angela DeMichele, Tari King, Priscilla F McAuliffe, Julie Nangia, Joanna Lee, Jennifer Tseng, Anna Maria Storniolo, Alastair M Thompson, Gaorav P Gupta, Robyn Burns, Deborah J Veis, Katherine DeSchryver, Chunfang Zhu, Magdalena Matusiak, Jason Wang, Shirley X Zhu, Jen Tappenden, Daisy Yi Ding, Dadong Zhang, Jingqin Luo, Shu Jiang, Sushama Varma, Lauren Anderson, Cody Straub, Sucheta Srivastava, Christina Curtis, Rob Tibshirani, Robert Michael Angelo, Allison Hall, Kouros Owzar, Kornelia Polyak, Carlo Maley, Jeffrey R Marks, Graham A Colditz, E Shelley Hwang, Robert B West Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts Ductal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We perform multiscale, integrated molecular profiling of DCIS with clinical outcomes by analyzing 774 DCIS samples from 542 patients with 7.3 years median follow-up... 11/18/2022
Maria Tejada-Casado, Razvan Ghinea, Miguel Ángel Martínez-Domingo, María M Pérez, Juan C Cardona, Javier Ruiz-López, Luis Javier Herrera Validation of a Hyperspectral Imaging System for Color Measurement of In-Vivo Dental Structures A full comprehension of colorimetric relationships within and between teeth is key for aesthetic success of a dental restoration. In this sense, hyperspectral imaging can provide point-wise reliable measurements of the tooth surface, which can serve for this purpose. The aim of this study was to use... 11/11/2022
Mohammad Abu-Abaa, Malik AbuBakar, Aliaa Mousa, Daniel Landau Desvenlafaxine As the Main Possible Culprit in Triggering Reversible Cerebral Vasoconstriction Syndrome: A Case Report Reversible cerebral vasoconstriction syndrome (RCVS) is not an uncommon condition. It should be suspected in young patients with new onset headaches and neurologic deficits. We report a 38-year-old male patient with a history of depression on desvenlafaxine for two years and no other triggering fact... 11/7/2022
Jana Štundlová, Monika Hospodářská, Karolína Lukšíková, Anna Voleníková, Tomáš Pavlica, Marie Altmanová, Annekatrin Richter, Martin Reichard, Martina Dalíková, Šárka Pelikánová, Anatolie Marta, Sergey A Simanovsky, Matyáš Hiřman, Marek Jankásek, Tomáš Dvořák, Joerg Bohlen, Petr Ráb, Christoph Englert, Petr Nguyen, Alexandr Sember Sex chromosome differentiation via changes in the Y chromosome repeat landscape in African annual killifishes Nothobranchius furzeri and N. kadleci Homomorphic sex chromosomes and their turnover are common in teleosts. We investigated the evolution of nascent sex chromosomes in several populations of two sister species of African annual killifishes, Nothobranchius furzeri and N. kadleci, focusing on their under-studied repetitive landscape. We ... 10/8/2022
Amanda L Nash, Samantha M Thomas, Suniti N Nimbkar, Tina J Hieken, Kandice K Ludwig, Lisa K Jacobs, Megan E Miller, Kristalyn K Gallagher, Jasmine Wong, Heather B Neuman, Jennifer Tseng, Taryn E Hassinger, Tari A King, E Shelley Hwang, James W Jakub, Laura H Rosenberger Racial-ethnic variations in phyllodes tumors among a multicenter United States cohort CONCLUSIONS: Differences in age, tumor size, and subtype were small. Therefore, the workup of young women with breast masses and the treatment of women with PT should not differ according to race-ethnicity. These conclusions are supported by our finding that there were no differences in recurrence-f... 10/7/2022
Aviv Goldbart, Moran Lavie, Ronit Lubetzky, Giora Pillar, Daniel Landau, Yechiel Schlesinger, Ronen Spiegel, Inbal Golan-Tripto, Amit Nahum, David Greenberg, Asher Tal Inhaled Nitric Oxide for the Treatment of Acute Bronchiolitis: A Multicenter Randomized Controlled Trial to Evaluate Dose Response CONCLUSION: Treatment with high dose intermittent iNO at 150 ppm showed reduced time to clinical improvement when compared to 85 ppm or control treatment of hospitalized infants with acute bronchiolitis. The 150 ppm iNO dose is well-tolerated, with significant benefit compared to both standard thera... 9/28/2022
Evgenia Gurevich, Yael Borovitz, Shelli Levi, Sharon Perlman, Daniel Landau Idiopathic infantile hypercalcemia in children with chronic kidney disease due to kidney hypodysplasia CONCLUSIONS: Transient IIH was observed in infants with KHD, in association with hypophosphatemia, resembling SLC34A1 and SLC34A3 pathogenic variants' metabolic profile. A higher resolution version of the Graphical abstract is available as Supplementary information. 9/26/2022
Omar A Zeidan, Ethan Pepmiller, Twyla Willoughby, Zhiqiu Li, James Burkavage, Brian Harper, Michael Fraser, Katie Moffatt, Sanford L Meeks, Naren Ramakrishna Operational Performance of a Compact Proton Therapy System: A 5-Year Experience CONCLUSION: Our data show that this compact system is versatile, robust, and capable of delivering complex treatments like a large full-gantry system. Utilization data show that a fraction of all subcomponents range of angular motion has been used. Compilation of beam-specific metrics, such as range... 9/5/2022
Marianna V Papageorge, Susanna W L de Geus, Alison P Woods, Sing Chau Ng, Samuel Lee, David McAneny, Jennifer F Tseng, Kelly M Kenzik, Teviah E Sachs Surveillance Patterns for Hepatocellular Carcinoma among Screening-Eligible Patients in the Medicare Population CONCLUSIONS: A large proportion of screening-eligible patients do not undergo routine surveillance, which is associated with late-stage diagnosis and higher risk of mortality. These findings demonstrate the impact of timely and consistent healthcare access and can guide interventions for promoting s... 9/4/2022
Adnan S Hussaini, Daniel D Swanson, Peter L Nguy, Kristen S Pan, Luis F de Castro, Alison M Boyce, Michael T Collins, Timothy R DeKlotz Malignant Sarcomatous Degeneration of Craniofacial Fibrous Dysplasia BACKGROUND: Fibrous dysplasia (FD) is an uncommon bone disease characterized by the replacement of normal bone architecture with abnormal fibro-osseous connective tissue. Here, we discuss 2 cases of craniofacial FD, with malignant sarcomatous degeneration - a rare and morbid complication of the dise... 9/2/2022
Tereza Hendrychova, Michal Svoboda, Josef Maly, Jiri Vlcek, Eva Zimcikova, Tomas Dvorak, Jaromir Zatloukal, Eva Volakova, Marek Plutinsky, Kristian Brat, Patrice Popelkova, Michal Kopecky, Barbora Novotna, Vladimir Koblizek Self-Reported Overall Adherence and Correct Inhalation Technique Discordance in Chronic Obstructive Pulmonary Disease Population Background: Adherence to inhaled medication constitutes a major problem in patients with chronic obstructive pulmonary disease (COPD) globally. However, large studies evaluating adherence in its entirety and capturing a large variety of potentially associated factors are still lacking. Objective: To... 8/29/2022
Michael Geylis, Tara Coreanu, Victor Novack, Daniel Landau Risk factors for childhood chronic kidney disease: a population-based study CONCLUSIONS: CKD is more prevalent among children in southern Israel than previously reported, even after excluding those with aborted-CKD. Prenatal conditions increase the risk to develop CKD in childhood. Graphical abstract A higher resolution version of the Graphical abstract is available as Supp... 8/26/2022
Swetha Duraiswamy, Sabrina E Sanchez, David R Flum, Michael K Paasche-Orlow, Kelly M Kenzik, Jennifer F Tseng, Frederick Thurston Drake Caveat emptor: The accuracy of claims data in appendicitis research CONCLUSION: International Classification of Disease, ninth/tenth revision codes do not accurately identify surgeon-described complicated appendicitis. Nearly one-third of the cases of complicated appendicitis were coded as uncomplicated. Such misclassification negatively impacts reimbursement for co... 8/19/2022
Charles A Gusho, David King, Cecilia G Ethun, Kenneth Cardona, J Harrison Howard, Thuy B Tran, George Poultsides, Jennifer Tseng, Kevin K Roggin, Ryan C Fields, Darren R Cullinan, Konstantinos Chouliaras, Konstantinos Votanopoulos, Valerie P Grignol, Meena Bedi Extraskeletal myxoid chondrosarcoma: Clinicopathological features and outcomes from the United States sarcoma collaborative database CONCLUSIONS: Long-term survival with EMC is probable, however there exists a high incidence of locoregional recurrence. While chemotherapy and radiation were associated with a worse RFS, these findings were likely confounded by recurrent disease as significance was lost in the primary EMC-only subse... 8/13/2022
Kevin J Contrera, Andrew T Huang, Jared A Shenson, Chad Tang, Dianna Roberts, Jeffrey N Myers, Randal S Weber, Stephen Y Lai, Michelle Williams, Maria El-Hallal, Denny Jacob, Mark Zafereo Primary and recurrent regional metastases for lateralized oral cavity squamous cell carcinoma CONCLUSIONS: For lateralized OCSCC, elective neck dissection of level IIB or the contralateral neck may rarely be needed, but additional surgical or radiation treatment of levels IV and V may be considered based on patient risk factors, including T category 3-4 or LVI. For upper alveolar/hard palate... 8/6/2022
Paige Teller, Toan T Nguyen, Jennifer Tseng, Lisa Allen, Cindy B Matsen, Emily Bellavance, David Kaufman, Tina Hieken, Steven Nagel, Caitlin Patten, Laura Pomerenke, Sarah E Tevis, Terry Sarantou Innovation in Breast Surgery: Practical and Ethical Considerations The adoption of innovation is essential to the evolution of patient care. Breast surgical oncology advances through incorporating new techniques, devices, and procedures. Historical changes in practice standards from radical to modified radical mastectomy or axillary node dissection to sentinel node... 7/19/2022
Marianna V Papageorge, Alison P Woods, Susanna W L de Geus, Sing Chau Ng, David McAneny, Jennifer F Tseng, Kelly M Kenzik, Teviah E Sachs The Persistence of Poverty and its Impact on Cancer Diagnosis, Treatment and Survival CONCLUSIONS: The duration of poverty has a direct impact on cancer-specific outcomes, with the greatest effect seen in persistent poverty and resolution of disparities when a county is no longer in poverty. Policy focused on directing resources to communities in persistent poverty may represent a po... 7/7/2022
María M Pérez, Francisco Carrillo-Perez, Maria Tejada-Casado, Javier Ruiz-López, Cristina Benavides-Reyes, Luis Javier Herrera CIEDE2000 lightness, chroma and hue human gingiva thresholds CONCLUSIONS: Statistically differences in perceptual limit were found among hue, lightness and chroma for human gingiva. Thus, the observers seem to show lower sensitivity for changes in hue (ΔH^(')) than in chroma (ΔC^(')) and in lightness (ΔL^(')) in the gingiva color space. 7/6/2022
Amanda Cox, Ana Martini, Heba Ghozlan, Rebecca Moroose, Xiang Zhu, Eunkyung Lee, Amr S Khaled, Louis Barr, Carlos Alemany, Na'im Fanaian, Elizabeth Griffith, Ryan Sause, S A Litherland, Annette R Khaled Chaperonin containing TCP1 as a marker for identification of circulating tumor cells in blood Herein we report the use of Chaperonin-Containing TCP-1 (CCT or TRiC) as a marker to detect circulating tumor cells (CTCs) that are shed from tumors during oncogenesis. Most detection methods used in liquid biopsy approaches for enumeration of CTCs from blood, employ epithelial markers like cytokera... 6/24/2022
Susanna Wl de Geus, Marianna V Papageorge, Alison P Woods, Spencer Wilson, Sing Chau Ng, Andrea Merrill, Michael Cassidy, David McAneny, Jennifer F Tseng, Teviah E Sachs A Rising Tide Lifts All Boats: Impact of Combined Volume of Complex Cancer Operations on Surgical Outcomes in a Low-Volume Setting CONCLUSION: Patients who underwent complex operations at MVH had similar postoperative outcomes to those at HVH. MVH provide a model for the centralization of complex cancer surgery for patients who do not receive their care at HVH. 6/15/2022
Sharon H Giordano, Maria Alice B Franzoi, Sarah Temin, Carey K Anders, Sarat Chandarlapaty, Jennie R Crews, Jeffrey J Kirshner, Ian E Krop, Nancy U Lin, Aki Morikawa, Debra A Patt, Jane Perlmutter, Naren Ramakrishna, Nancy E Davidson Systemic Therapy for Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: ASCO Guideline Update PURPOSE: To update evidence-based guideline recommendations to practicing oncologists and others on systemic therapy for patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer. 5/31/2022
Naren Ramakrishna, Carey K Anders, Nancy U Lin, Aki Morikawa, Sarah Temin, Sarat Chandarlapaty, Jennie R Crews, Nancy E Davidson, Maria Alice B Franzoi, Jeffrey J Kirshner, Ian E Krop, Debra A Patt, Jane Perlmutter, Sharon H Giordano Management of Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases: ASCO Guideline Update PURPOSE: To provide updated evidence- and consensus-based guideline recommendations to practicing oncologists and others on the management of brain metastases for patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer up to 2021. 5/31/2022
Tracy S Wang, Eugene S Kim, Quan-Yang Duh, Ankush Gosain, Lillian S Kao, Anai N Kothari, Susan Tsai, Jennifer F Tseng, Allan Tsung, Kasper S Wang, Steven D Wexner Proceedings From the Advances in Surgery Channel Diversity, Equity, and Inclusion Series: Lessons Learned From Asian Academic Surgeons In this series of talks and the accompanying panel session, leaders from the Society of Asian Academic Surgeons discuss issues faced by Asian Americans and the importance of the role of mentors and allyship in professional development in the advancement of Asian Americans in leadership roles. Barrie... 5/19/2022
Mirza Zain Baig, Syed S Razi, Kojo Agyabeng-Dadzie, Stephanie Stroever, Zaid Muslim, Joanna Weber, Luis J Herrera, Faiz Y Bhora Robotic-assisted thoracoscopic surgery demonstrates a lower rate of conversion to thoracotomy than video-assisted thoracoscopic surgery for complex lobectomies CONCLUSIONS: Our analysis of the National Cancer Database suggests that robotic lobectomy for complex lung resections achieves similar perioperative outcomes and R0 resections as VATS lobectomy with the exception of a lower rate of conversion to thoracotomy. 5/11/2022
Zaid Muslim, Stephanie Stroever, Kostantinos Poulikidis, Joanna F Weber, Cliff P Connery, Luis J Herrera, Faiz Y Bhora Conversion to Thoracotomy in Non-Small Cell Lung Cancer: Risk Factors and Perioperative Outcomes Objective: We aimed to identify predictors of conversion to thoracotomy and test the hypothesis that conversion is associated with inferior perioperative outcomes in non-small cell lung cancer (NSCLC). Methods: We queried the National Cancer Database for patients with stage I to III NSCLC undergoing... 5/2/2022
Francisco Carrillo-Perez, Juan Carlos Morales, Daniel Castillo-Secilla, Olivier Gevaert, Ignacio Rojas, Luis Javier Herrera Machine-Learning-Based Late Fusion on Multi-Omics and Multi-Scale Data for Non-Small-Cell Lung Cancer Diagnosis Differentiation between the various non-small-cell lung cancer subtypes is crucial for providing an effective treatment to the patient. For this purpose, machine learning techniques have been used in recent years over the available biological data from patients. However, in most cases this problem h... 4/23/2022
Sergio Ortiz, Fernando Rojas, Olga Valenzuela, Luis Javier Herrera, Ignacio Rojas Determination of the Severity and Percentage of COVID-19 Infection through a Hierarchical Deep Learning System The coronavirus disease 2019 (COVID-19) has caused millions of deaths and one of the greatest health crises of all time. In this disease, one of the most important aspects is the early detection of the infection to avoid the spread. In addition to this, it is essential to know how the disease progre... 4/23/2022
Christopher A French, Michael L Cheng, Glenn J Hanna, Steven G DuBois, Nicole G Chau, Christine L Hann, Simone Storck, Ravi Salgia, Matteo Trucco, Jennifer Tseng, Anastasios Stathis, Richard Piekarz, Ulrich M Lauer, Christophe Massard, Kelly Bennett, Shodeinde Coker, Ulrike Tontsch-Grunt, Martin L Sos, Sida Liao, Catherine J Wu, Kornelia Polyak, Sarina A Piha-Paul, Geoffrey I Shapiro Report of the First International Symposium on NUT Carcinoma NUT carcinoma is a rare, aggressive cancer defined by rearrangements of the NUTM1 gene. No routinely effective treatments of NUT carcinoma exist, despite harboring a targetable oncoprotein, most commonly BRD4-NUT. The vast majority of cases are fatal. Poor awareness of the disease is a major obstacl... 4/13/2022
Rivka Friedland, Khalaf Kridin, Arnon Dov Cohen, Daniel Landau, Dan Ben-Amitai Psoriasis and Renal Disorders: A Large-Scale Population-Based Study in Children and Adults CONCLUSION: As opposed to adult patients, pediatric patients with psoriasis were not shown at risk of kidney diseases. 3/3/2022
Cen Guo, Yanke Yu, Jayeta Chakrabarti, Sarina A Piha-Paul, Rebecca Moroose, Anna Plotka, Haihong Shi, Chandrasekar Durairaj, Diane D Wang, Zev A Wainberg Evaluation of pharmacokinetics and safety of talazoparib in patients with advanced cancer and varying degrees of hepatic impairment CONCLUSIONS: Hepatic impairment (mild, moderate or severe) has no impact on the PK of talazoparib. No dose modification is recommended for patients with advanced solid tumours and various degrees of hepatic impairment, and this labelling language has been approved by the US Food and Drug Administrat... 3/2/2022
Swetha Duraiswamy, Amanda Ignacio, Janice Weinberg, Sabrina E Sanchez, David R Flum, Michael K Paasche-Orlow, Kelly M Kenzik, Jennifer F Tseng, Frederick Thurston Drake Comparative Accuracy of ICD-9 vs ICD-10 Codes for Acute Appendicitis CONCLUSIONS: Compared with ICD-9 codes, ICD-10 codes were less accurate in characterizing severity of appendicitis. The ICD-10 coding schema does not provide an accurate representation of disease severity. Until this system is improved, significant caution is needed for people who rely on these data... 2/25/2022
Tomáš Dvořák, Vendula Šlechtová, Jörg Bohlen Using Species Groups to Approach the Large and Taxonomically Unresolved Freshwater Fish Family Nemacheilidae (Teleostei: Cypriniformes) Large animal families with unresolved taxonomy are notoriously difficult to handle with respect to their biodiversity, systematics, and evolutionary history. We approach a large and taxonomically unresolved family of freshwater fishes (Nemacheilidae, >600 species) by proposing, on the basis of morph... 2/25/2022
Marianna V Papageorge, Alison P Woods, Susanna W L de Geus, Sing Chau Ng, Michael K Paasche-Orlow, Dorry Segev, David McAneny, Kelly M Kenzik, Teviah E Sachs, Jennifer F Tseng Beyond insurance status: the impact of Medicaid expansion on the diagnosis of Hepatocellular Carcinoma CONCLUSION: Medicaid expansion was not associated with earlier stage diagnoses in patients with HCC, including those with higher social vulnerability. Unlike other cancers, expanded access did not translate into higher utilization of care in HCC, suggesting barriers on a multitude of levels. 1/19/2022
María Tejada-Casado, Razvan Ghinea, María M Perez, Henning Lübbe, Ioana S Pop-Ciutrila, Javier Ruiz-López, Luis Javier Herrera Reflectance and color prediction of dental material monolithic samples with varying thickness OBJECTIVE: To assess accuracy of reflectance reconstruction and color estimation of different dental materials with varying thicknesses using Principal Component Analysis (PCA). 1/17/2022
Malcolm Hart Squires, Cecilia G Ethun, Erin E Donahue, Jennifer H Benbow, Colin J Anderson, Megan H Jagosky, Munsa Manandhar, Joshua C Patt, Jeffrey S Kneisl, Jonathan C Salo, Joshua S Hill, William Ahrens, Roshan S Prabhu, Michael B Livingston, Nicole L Gower, McKenzie Needham, Sally J Trufan, Ryan C Fields, Bradley A Krasnick, Meena Bedi, Konstantinos Votanopoulos, Konstantinos Chouliaras, Valerie Grignol, Kevin K Roggin, Jennifer Tseng, George Poultsides, Thuy B Tran, Kenneth Cardona, J Harrison Howard Extremity Soft Tissue Sarcoma: A Multi-Institutional Validation of Prognostic Nomograms CONCLUSIONS: Sarculator and MSKCC nomograms demonstrated good prognostic ability for survival and recurrence outcomes in a modern, multi-institutional validation cohort of resected primary extremity STS patients. External validation of these nomograms supports their ongoing incorporation into clinic... 1/11/2022
Marianna V Papageorge, Susanna W L de Geus, Alison P Woods, Sing Chau Ng, David McAneny, Jennifer F Tseng, Kelly M Kenzik, Teviah E Sachs The Effect of Hospital Versus Surgeon Volume on Short-Term Patient Outcomes After Pancreaticoduodenectomy: a SEER-Medicare Analysis CONCLUSION: Compared with surgeon volume, hospital volume is a more significant factor in predicting short-term outcomes after PD. This suggests that a focus on resources and care pathways, in combination with volume metrics, is more likely to achieve high-quality care for patients undergoing PD acr... 1/7/2022
Marianna V Papageorge, Susanna W L de Geus, Alison P Woods, Sing Chau Ng, F Thurston Drake, Andrea Merrill, Michael R Cassidy, David McAneny, Jennifer F Tseng, Teviah E Sachs Lymphadenectomy in gallbladder adenocarcinoma: Are we doing enough? CONCLUSIONS: The majority of patients with gallbladder adenocarcinoma do not undergo the recommended nodal dissection, resulting in a survival disadvantage, likely due to understaging, decisions regarding adjuvant therapy and local tumor recurrence. 1/1/2022
Ruth Schreiber, Vadim Dolgin, Daniel Landau, Evgenia Gurevich, Hanna Shalev, Michael Geylis RENAL TUBULAR DYSGENESIS SECONDARY TO MUTATIONS IN GENES ENCODING THE RENIN-ANGIOTENSIN SYSTEM Autosomal recessive renal tubular dysgenesis (RTD;OMIM: 267430) is a rare kidney disease secondary to mutations in genes encoding the renin-angiotensin system which have a role in renal tissue development during fetal life and in the maintenance of blood pressure and electrolyte balance. The disease... 12/27/2021
Dor Fisher, Yael Borovitz, Hadas Alfandari, Shelly LEvi, Gilad Hamdani, Amit Dagan, Miriam Davidovits, Daniel Landau, Orly Haskin NEPHROTIC SYNDROME RECURRENCE POST-RENAL TRANSPLANTATION: 10 YEARS' EXPERIENCE AT SCHNEIDER CHILDREN'S MEDICAL CENTER IN ISRAEL CONCLUSIONS: Post-transplant recurrence of SRNS continues to pose a significant treatment challenge. Similar to previous reports, only 50% of our patients responded to treatment while 50% were unresponsive to all treatment modalities and reached ESRD. Immediate post-operative management improved ove... 12/27/2021
Evgenia Gurevich, Yael Segev, Daniel Landau Growth Hormone and IGF1 Actions in Kidney Development and Function Growth hormone (GH) exerts multiple effects on different organs including the kidneys, either directly or via its main mediator, insulin-like-growth factor-1 (IGF-1). The GH/IGF1 system plays a key role in normal kidney development, glomerular hemodynamic regulation, as well as tubular water, sodium... 12/24/2021
Marianna V Papageorge, Susanna W L de Geus, Alison P Woods, Sing Chau Ng, David McAneny, Jennifer F Tseng, Kelly M Kenzik, Teviah E Sachs The impact of upper gastrointestinal surgical volume on short term pancreaticoduodenectomy outcomes for pancreatic adenocarcinoma in the SEER-Medicare population CONCLUSION: Patients with pancreatic adenocarcinoma who are older and more medically complex benefit from undergoing surgery at high volume PD centers, independent of the operative experience of that center. 12/9/2021
Jared A Shenson, Ivana Jankovic, Hyo Jung Hong, Benjamin Weia, Lee White, Jonathan H Chen, Matthew Eisenberg Engaging Housestaff as Informatics Collaborators: Educational and Operational Opportunities CONCLUSION: The council model has effectively engaged housestaff as learners, local champions, and key informatics collaborators, with positive impact for the participating members and the institution. Requiring few resources for implementation, the model should be replicable at other institutions. 12/8/2021
Francisco Carrillo-Perez, Oscar E Pecho, Juan Carlos Morales, Rade D Paravina, Alvaro Della Bona, Razvan Ghinea, Rosa Pulgar, María Del Mar Pérez, Luis Javier Herrera Applications of artificial intelligence in dentistry: A comprehensive review CONCLUSIONS: The insight provided by the present work has reported outstanding results in the design of high-performance decision support systems for the aforementioned areas. The future of digital dentistry goes through the design of integrated approaches providing personalized treatments to patien... 11/29/2021
Shelly Levi, Miriam Davidovits, Hadas Alfandari, Amit Dagan, Yael Borovitz, Efraim Bilavsky, Daniel Landau, Orly Haskin EBV, CMV, and BK viral infections in pediatric kidney transplantation: Frequency, risk factors, treatment, and outcomes CONCLUSIONS: Viral infections continue to be a major cause of morbidity in pediatric kidney transplant recipients. However, with close monitoring and prompt intervention, patient and renal outcomes remain favorable. 11/24/2021
Evgenia Gurevich, Shelly Steiling, Daniel Landau Incidence of Impaired Kidney Function Among Adolescent Patients Hospitalized With Anorexia Nervosa CONCLUSIONS AND RELEVANCE: Impaired kidney function in patients with AN is common and transiently worsens during hospitalization. SCr values probably underestimate the degree of kidney function impairment in AN. Results of this study found that patients with impaired kidney function had worse anorex... 11/22/2021
Expert Panel on Breast Imaging, Ann Brown, Ana P Lourenco, Bethany L Niell, Beth Cronin, Elizabeth H Dibble, Maggie L DiNome, Mita Sanghavi Goel, Juliana Hansen, Samantha L Heller, Maxine S Jochelson, Baer Karrington, Katherine A Klein, Tejas S Mehta, Mary S Newell, Loren Schechter, Ashley R Stuckey, Mary E Swain, Jennifer Tseng, Daymen S Tuscano, Linda Moy ACR Appropriateness Criteria® Transgender Breast Cancer Screening Breast cancer screening recommendations for transgender and gender nonconforming individuals are based on the sex assigned at birth, risk factors, and use of exogenous hormones. Insufficient evidence exists to determine whether transgender people undergoing hormone therapy have an overall lower, ave... 11/19/2021
Michael J Brenner, Jared A Shenson, Austin S Rose, Tulio A Valdez, Masayoshi Takashima, Omar G Ahmed, Philip A Weissbrod, Robert S Hong, Hamid Djalilian, Jeffrey S Wolf, Robert J Morrison, Peter L Santa Maria, Isaac D Erbele New Medical Device and Therapeutic Approvals in Otolaryngology: State of the Art Review 2020 CONCLUSIONS: The Medical Devices and Drugs Committee reviewed 53 new therapeutics and 1094 devices (89 ENT, 140 anesthesia, 511 plastic and general surgery, and 354 neurology) approved in 2020. Ten drugs and 17 devices were considered relevant to the otolaryngology community. Rhinology saw significa... 11/18/2021
Chelsea R Olson, Lorena P Suarez-Kelly, Cecilia G Ethun, Rita D Shelby, Peter Y Yu, Tasha M Hughes, Marilly Palettas, Thuy B Tran, George Poultsides, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley A Krasnick, Ryan C Fields, David M King, Meena Bedi, Raphael E Pollock, Valerie P Grignol, Kenneth Cardona, J Harrison Howard Resection Status Does Not Impact Recurrence in Well-Differentiated Liposarcoma of the Extremity BACKGROUND: Well-differentiated liposarcoma (WDLPS) is a low-grade soft tissue sarcoma with a propensity for local recurrence. The necessity of obtaining microscopically free surgical margins (R0) to minimize local recurrence is not clear. This study evaluates recurrence-free survival (RFS) of extre... 11/11/2021
Cameron W Swanick, Jing Jiang, J Alberto Maldonado, Xiudong Lei, Ya-Chen Tina Shih, Abigail S Caudle, Donald P Baumann, Sharon H Giordano, Simona F Shaitelman, Shervin M Shirvani, Benjamin D Smith Differences in Time Burden across Local Therapy Strategies for Early-stage Breast Cancer CONCLUSIONS: Although Mast+Recon confers the highest inpatient and outpatient time burden, Lump+WBI carries the highest total time burden. Increased use of hypofractionation will reduce the total time burden for Lump+WBI. 11/8/2021
Curtis M Bryant, Randal H Henderson, R Charles Nichols, William M Mendenhall, Bradford S Hoppe, Carlos E Vargas, Thomas B Daniels, C Richard Choo, Rahul R Parikh, Huan Giap, Jerry D Slater, Neha Vapiwala, William Barrett, Akash Nanda, Mark V Mishra, Seungtaek Choi, Jay J Liao, Nancy P Mendenhall, Genitourinary Subcommittee of the Particle Therapy Co-Operative Group Consensus Statement on Proton Therapy for Prostate Cancer Proton therapy is a promising but controversial treatment in the management of prostate cancer. Despite its dosimetric advantages when compared with photon radiation therapy, its increased cost to patients and insurers has raised questions regarding its value. Multiple prospective and retrospective ... 11/1/2021
Adnan S Hussaini, Navin R Prasad, Edina Paal, Eshetu A Tefera, Sonya Malekzadeh, Jessica H Maxwell The distribution of parotid gland neoplasms in a veteran population CONCLUSION: Among our cohort of veteran patients, WT was the most common benign parotid tumor and has increased in incidence over the last two decades despite an unchanged smoking rate. 10/11/2021
Craig L Slingluff, Karl D Lewis, Robert Andtbacka, John Hyngstrom, Mohammed Milhem, Svetomir N Markovic, Tawnya Bowles, Omid Hamid, Leonel Hernandez-Aya, Joel Claveau, Sekwon Jang, Prejesh Philips, Shernan G Holtan, Montaser F Shaheen, Brendan Curti, William Schmidt, Marcus O Butler, Juan Paramo, Jose Lutzky, Arvinda Padmanabhan, Sajeve Thomas, Daniel Milton, Andrew Pecora, Takami Sato, Eddy Hsueh, Suprith Badarinath, John Keech, Sujith Kalmadi, Pallavi Kumar, Robert Weber, Edward Levine, Adam Berger, Anna Bar, J Thaddeus Beck, Jeffrey B Travers, Catalin Mihalcioiu, Brian Gastman, Peter Beitsch, Suthee Rapisuwon, John Glaspy, Edward C McCarron, Vinay Gupta, Deepti Behl, Brent Blumenstein, Joanna J Peterkin Multicenter, double-blind, placebo-controlled trial of seviprotimut-L polyvalent melanoma vaccine in patients with post-resection melanoma at high risk of recurrence CONCLUSIONS: Seviprotimut-L is very well tolerated. Exploratory efficacy model estimation supports further study in stage IIB/IIC patients, especially younger patients and those with ulcerated melanomas. 10/2/2021
Francisco Carrillo-Perez, Juan Carlos Morales, Daniel Castillo-Secilla, Yésica Molina-Castro, Alberto Guillén, Ignacio Rojas, Luis Javier Herrera Non-small-cell lung cancer classification via RNA-Seq and histology imaging probability fusion CONCLUSIONS: These findings suggest that a classification model using a late fusion methodology can considerably help clinicians in the diagnosis between the aforementioned lung cancer cancer subtypes over using each source of information separately. This approach can also be applied to any cancer t... 9/23/2021
Michael S Kent, Matthew G Hartwig, Eric Vallières, Abbas E Abbas, Robert J Cerfolio, Mark R Dylewski, Thomas Fabian, Luis J Herrera, Kimble G Jett, Richard S Lazzaro, Bryan Meyers, Brian A Mitzman, Rishindra M Reddy, Michael F Reed, David C Rice, Patrick Ross, Inderpal S Sarkaria, Lana Y Schumacher, William B Tisol, Dennis A Wigle, Michael Zervos Pulmonary Open, Robotic and Thoracoscopic Lobectomy (PORTaL) Study: An Analysis of 5,721 Cases CONCLUSIONS: RL and VATS approaches were associated with favorable perioperative outcomes compared to OL. Robotic-assisted lobectomy was also associated with a reduced length of stay and decreased conversion rate when compared to VATS. 9/17/2021
Pooja Gurnani, Tamir Miloh, Jayanthi Chandar, Daniel A Landau, Fouad Hajjar, Gil Yosipovitch Systemic causes of non-dermatologic chronic pruritus in the pediatric population and their management: An unexplored area Chronic pruritus associated with systemic diseases in the pediatric population has been infrequently addressed in the literature. This review focuses on chronic pruritus presenting without cutaneous manifestations. Common systemic etiologies include diseases with hepatic, renal, and hematologic orig... 9/13/2021
Marianna V Papageorge, Douglas B Evans, Jennifer F Tseng Health Care Disparities and the Future of Pancreatic Cancer Care There have been tremendous advances in the diagnosis and treatment of pancreatic cancer in the past decade, yet we are failing to achieve equitable outcomes for all patient populations. Disparities exist in the incidence, diagnosis, treatment, and outcomes of patients with pancreatic cancer. Inequit... 9/13/2021
Efrat Talgam-Horshi, Yael Mozer-Glassberg, Orit Waisbourd-Zinman, Liat Ashkenazi-Hoffnung, Orly Haskin, Shelly Levi, Gilad Hamdani, Daniel Landau, Hadas Alfandary Clinical Outcomes and Antibody Response in COVID-19-Positive Pediatric Solid Organ Transplant Recipients We describe the clinical and laboratory manifestations and outcomes of 25 pediatric solid organ transplant recipients who tested positive for severe acute respiratory coronavirus-2. Twenty-one (84%) developed a mild disease; 22 of 23 (96%) had a positive serologic response. Two patients (8%), both k... 8/12/2021
Orly Haskin, Liat Ashkenazi-Hoffnung, Noa Ziv, Yael Borovitz, Amit Dagan, Shelly Levi, Gili Koren, Gilad Hamdani, Daniella Levi-Erez, Daniel Landau, Hadas Alfandary Serological Response to the BNT162b2 COVID-19 mRNA Vaccine in Adolescent and Young Adult Kidney Transplant Recipients CONCLUSIONS: The BNT162b2 COVID-19 mRNA vaccine yielded higher positive antibody response in adolescent and young adult KTR than previously reported for adult KTR. Antibody titers after vaccination were significantly lower than following COVID-19 infection. Longer time may be required to mount appro... 8/12/2021
Rachel M Lee, Cecilia G Ethun, Adriana C Gamboa, Michael K Turgeon, Thuy Tran, George Poultsides, Valerie Grignol, Meena Bedi, Harveshp Mogal, Callisia N Clarke, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley A Krasnick, Ryan C Fields, Shervin V Oskouei, David K Monson, Nickolas B Reimer, Shishir K Maithel, Allan Pickens, Kenneth Cardona A novel preoperative risk score to guide patient selection for resection of soft tissue sarcoma lung metastases: An analysis from the United States Sarcoma Collaborative CONCLUSION: We identified four characteristics that in aggregate portend a worse OS and created a novel prognostic risk score for patients with sarcoma lung metastases. Given that patients in the high-risk group have a projected OS of <20% at 5 years, this risk score, after external validation, will... 8/10/2021
Luise I Pernar, Teviah E Sachs, Jennifer F Tseng, Donald T Hess Structuring Research Rotations to Facilitate Surgery Residents' Academic Productivity CONCLUSIONS: Through establishment of dedicated research rotations, we were able to increase resident engagement in a variety of research activities. We provide a simple model for training programs seeking increased research engagement and productivity for their residents without extending training ... 8/9/2021
Hava Peretz, Ayala Lagziel, Florian Bittner, Mustafa Kabha, Meirav Shtauber-Naamati, Vicki Zhuravel, Sali Usher, Steffen Rump, Silke Wollers, Bettina Bork, Hanna Mandel, Tzipora Falik-Zaccai, Limor Kalfon, Juergen Graessler, Avraham Zeharia, Nasser Heib, Hannah Shalev, Daniel Landau, David Levartovsky Classical Xanthinuria in Nine Israeli Families and Two Isolated Cases from Germany: Molecular, Biochemical and Population Genetics Aspects Classical xanthinuria is a rare autosomal recessive metabolic disorder caused by variants in the XDH (type I) or MOCOS (type II) genes. Thirteen Israeli kindred (five Jewish and eight Arab) and two isolated cases from Germany were studied between the years 1997 and 2013. Four and a branch of a fifth... 8/6/2021
Luis J Herrera, Eric M Wherley, Kojo Agyabeng-Dadzie, Bhupaul Ramsuchit, Matthew A Johnston, Juan C Escalon 500 Consecutive Robotic Lobectomies for Non-Small Cell Lung Cancer: Perioperative and Oncologic Outcomes CONCLUSIONS: Robotic lobectomy for lung cancer is a feasible technique for treatment of non-small cell lung cancer with low perioperative morbidity and mortality. Furthermore, excellent oncologic outcomes can be achieved with this approach. 8/5/2021
Swati A Kulkarni, Kirti Kulkarni, David Schacht, Sonya Bhole, Ingrid Reiser, Hiroyuki Abe, Jean Bao, Kevin Bethke, Nora Hansen, Nora Jaskowiak, Seema A Khan, Jennifer Tseng, Buxin Chen, Jennifer Pincus, Jeffrey Mueller, Lauren Schulte, Bazil LaBomascus, Zheng Zhang, Dan Xia, Xiaochuan Pan, Christian Wietholt, Dimple Modgil, David Lester, Li Lan, Bidur Bohara, Xiao Han High-Resolution Full-3D Specimen Imaging for Lumpectomy Margin Assessment in Breast Cancer CONCLUSIONS: The ROC curves of the VSI were higher than those of the other specimen imaging methods. Full-3D specimen imaging can improve the correlation between the main lumpectomy specimen margin status and surgical pathology. The findings from this study suggest that using the VSI device for intr... 8/1/2021
Nosayaba Osazuwa-Peters, Justin M Barnes, Somtochi I Okafor, Derian B Taylor, Adnan S Hussaini, Eric Adjei Boakye, Matthew C Simpson, Evan M Graboyes, Walter T Lee Incidence and Risk of Suicide Among Patients With Head and Neck Cancer in Rural, Urban, and Metropolitan Areas CONCLUSIONS AND RELEVANCE: The findings of this cross-sectional study suggest that suicide risk is elevated in general among patients with HNC but is significantly higher for patients residing in rural areas. Effective suicide prevention strategies in the population of patients with HNC need to acco... 7/23/2021
Malcolm H Squires, Cecilia G Ethun, Erin E Donahue, Jennifer H Benbow, Colin J Anderson, Megan H Jagosky, Jonathan C Salo, Joshua S Hill, William Ahrens, Roshan S Prabhu, Michael B Livingston, Nicole L Gower, Mckenzie Needham, Sally J Trufan, Ryan C Fields, Bradley A Krasnick, Meena Bedi, Daniel E Abbott, Patrick Schwartz, Konstantinos Votanopoulos, Konstantinos Chouliaras, Valerie Grignol, Kevin K Roggin, Jennifer Tseng, George Poultsides, Thuy B Tran, Kenneth Cardona, J Harrison Howard A multi-institutional validation study of prognostic nomograms for retroperitoneal sarcoma CONCLUSIONS: In a diverse, modern validation cohort of patients with resected primary RPS, both Sarculator and MSK nomograms demonstrated good prognostic ability, supporting their ongoing adoption into clinical practice. 7/13/2021
Tatyana A Grushko, Virginia L Filiaci, Anthony G Montag, Marsha Apushkin, Maria J Gomez, Laura Monovich, Nilsa C Ramirez, Carlton Schwab, Joshua P Kesterson, Shelly M Seward, Michael W Method, Olufunmilayo I Olopade, Gini F Fleming, Michael J Birrer Effects of Slide Storage on Detection of Molecular Markers by IHC and FISH in Endometrial Cancer Tissues From a Clinical Trial: An NRG Oncology/GOG Pilot Study We performed a pilot study in anticipation of using long-aged precut formalin-fixed paraffin-embedded tissue sections stored in real-world conditions for translational biomarker studies of topoisomerase 2A (TOP2A), Ki67, and human epidermal growth factor receptor 2 (HER2) in endometrial cancer. Form... 7/5/2021
Arun Gopinathan, Jaroslav Jerz, Jaroslav Kováčik, Tomáš Dvorák Investigation of the Relationship between Morphology and Thermal Conductivity of Powder Metallurgically Prepared Aluminium Foams Among different promising solutions, coupling closed-cell aluminium foam composite panels prepared by a powder metallurgical method with pore walls interconnected by microcracks, with low thermal conductivity phase change materials (PCMs), is one of the effective ways of increasing thermal conductiv... 7/2/2021
Herbert Chen, Jennifer F Tseng, Rabih Chaer, David A Spain, John H Stewart, Daniel Dent, Beatriz Ibáñez, Carol L Barry, Andrew T Jones, Jo Buyske Outcomes of the First Virtual General Surgery Certifying Exam of the American Board of Surgery CONCLUSIONS: The first virtual CE by the ABS was completed using available internet technology. There was high satisfaction, with the majority preferring the virtual platform. Compared to past in-person CEs, there was no difference in outcomes as measured by passing rates. These data suggest that ex... 6/29/2021
Saam A Mojtahed, Nicole R Boyer, Saieesh A Rao, Thomas F Gajewski, Jennifer Tseng, Kiran K Turaga Cost-Effectiveness Analysis of Adjuvant Therapy for BRAF-Mutant Resected Stage III Melanoma in Medicare Patients CONCLUSIONS: Pembrolizumab is cost-effective at a conventional willingness-to-pay (WTP) threshold, but dabrafenib-trametinib is not. Though dabrafenib-trametinib offers incremental QALYs, optimization of drug pricing is necessary to ensure dabrafenib-trametinib is accessible at an acceptable WTP thr... 6/15/2021
Julius K Weng, Xiudong Lei, Pamela Schlembach, Elizabeth S Bloom, Simona F Shaitelman, Isidora Y Arzu, Gregory Chronowski, Tomas Dvorak, Emily Grade, Karen Hoffman, George Perkins, Valerie K Reed, Shalin J Shah, Michael C Stauder, Eric A Strom, Welela Tereffe, Wendy A Woodward, Gabriel N Hortobagyi, Kelly K Hunt, Thomas A Buchholz, Benjamin D Smith Five-Year Longitudinal Analysis of Patient-Reported Outcomes and Cosmesis in a Randomized Trial of Conventionally Fractionated Versus Hypofractionated Whole-Breast Irradiation CONCLUSIONS: Both CF-WBI and HF-WBI confer similar longitudinal PROs and physician-rated cosmesis through 5 years of follow-up, with no relevant subsets that fared better with CF-WBI. This evidence supports broad adoption of hypofractionation with boost, including in patients receiving chemotherapy ... 5/16/2021
Laura H Rosenberger, Liza M Quintana, Samantha M Thomas, Suniti N Nimbkar, Tina J Hieken, Kandice K Ludwig, Lisa K Jacobs, Megan E Miller, Kristalyn K Gallagher, Jasmine Wong, Heather B Neuman, Jennifer Tseng, Taryn E Hassinger, Tari A King, James W Jakub, Rex C Bentley, Stuart J Schnitt Limited Reporting of Histopathologic Details in a Multi-Institutional Academic Cohort of Phyllodes Tumors: Time for Standardization CONCLUSION: In this academic cohort of phyllodes tumors, one or more histopathologic features were frequently omitted from the pathology report. While all features were considered by the pathologist for grading, this limited reporting reflects a lack of reporting consensus. We recommend that standar... 5/15/2021
Amod A Sarnaik, Omid Hamid, Nikhil I Khushalani, Karl D Lewis, Theresa Medina, Harriet M Kluger, Sajeve S Thomas, Evidio Domingo-Musibay, Anna C Pavlick, Eric D Whitman, Salvador Martin-Algarra, Pippa Corrie, Brendan D Curti, Judit Oláh, Jose Lutzky, Jeffrey S Weber, James M G Larkin, Wen Shi, Toshimi Takamura, Madan Jagasia, Harry Qin, Xiao Wu, Cecile Chartier, Friedrich Graf Finckenstein, Maria Fardis, John M Kirkwood, Jason A Chesney Lifileucel, a Tumor-Infiltrating Lymphocyte Therapy, in Metastatic Melanoma CONCLUSION: Lifileucel demonstrated durable responses and addresses a major unmet need in patients with metastatic melanoma with limited treatment options after approved therapy, including the primary refractory to anti-PD-1 or PD-L1 therapy subset. 5/12/2021
Yehuda Galili, Ahmad El-Far, Jennifer Tseng, Steve Carlan Role of immunotherapy in oligometastatic nonsmall cell lung cancer The approach to metastatic lung cancer has long been focused on palliation therapy and comfort care. Recently, significant subsets of patients who suffer from a limited form of the disease have shown curative outcomes. The oligometastatic disease theory was first introduced in 1995, and since has be... 5/11/2021
Kristian Brat, Michal Svoboda, Jaromir Zatloukal, Marek Plutinsky, Eva Volakova, Patrice Popelkova, Barbora Novotna, Tomas Dvorak, Vladimir Koblizek The Relation Between Clinical Phenotypes, GOLD Groups/Stages and Mortality in COPD Patients - A Prospective Multicenter Study CONCLUSION: Certain phenotypes ("Czech" or "Spanish") of COPD are associated with higher risk of death. Co-presence of multiple phenotypes (emphysematous plus cachectic plus frequent exacerbator) in a single individual was associated with amplified risk of mortality. 5/6/2021
Daniel Castillo-Secilla, Juan Manuel Gálvez, Francisco Carrillo-Perez, Marta Verona-Almeida, Daniel Redondo-Sánchez, Francisco Manuel Ortuno, Luis Javier Herrera, Ignacio Rojas KnowSeq R-Bioc package: The automatic smart gene expression tool for retrieving relevant biological knowledge KnowSeq R/Bioc package is designed as a powerful, scalable and modular software focused on automatizing and assembling renowned bioinformatic tools with new features and functionalities. It comprises a unified environment to perform complex gene expression analyses, covering all the needed processin... 4/19/2021
Marianna V Papageorge, Susanna W L de Geus, Jian Zheng, Alison P Woods, Sing Chau Ng, Michael R Cassidy, David McAneny, Jennifer F Tseng, Teviah E Sachs The Discordance of Clinical and Pathologic Staging in Locally Advanced Gastric Adenocarcinoma CONCLUSION: This study found a substantial discordance between clinical and pathologic staging of resectable locally advanced gastric adenocarcinoma. These data support that patients may have more advanced disease at presentation than reflected in clinical staging and may benefit from improved diagn... 4/13/2021
Sherif Aly, Susanna W L de Geus, Cullen O Carter, Teviah E Sachs, Donald T Hess, Jennifer F Tseng, Luise I M Pernar Impact of fellow compared to resident assistance on outcomes of minimally invasive surgery CONCLUSIONS: Surgical outcomes were similar between fellow and chief resident assistance in MIS operations, arguing that increased resident participation in basic and complex laparoscopic operations is appropriate without compromising patient safety. 3/25/2021
Juliana A Medeiros, Oscar E Pecho, María M Pérez, Francisco Carrillo-Pérez, Luis Javier Herrera, Alvaro Della Bona Influence of background color on color perception in dentistry CONCLUSIONS: The lowest AT values using a black background indicates that the use of this background allows for the evaluation of slight color differences, and should be used for challenging color differences in esthetic dentistry. This study showed the influence of the observer experience on color ... 3/24/2021
Inbar Bandach, Yael Segev, Daniel Landau Experimental modulation of Interleukin 1 shows its key role in chronic kidney disease progression and anemia Inflammation in chronic kidney disease (CKD) is mostly due to activation of the innate immune system, in which Interleukin-1 (IL-1) is a key player. Anemia of CKD may also be due to erythropoietin (EPO) resistance, clinically associated with inflammation. IL-1 receptor antagonist knockout (RaKO) mic... 3/19/2021
Susanna Wl de Geus, Alison P Woods, Marianna V Papageorge, Jian Zheng, Sing Chau Ng, David McAneny, Teviah E Sachs, Jennifer F Tseng Combined Hepatopancreaticobiliary Volume and Hepatectomy Outcomes in Hepatocellular Carcinoma Patients at Low-Volume Liver Centers CONCLUSIONS: LR outcomes at low-volume LR centers that have substantial experience with HPB cancer operations are similar to those at high-volume LR centers. Our results demonstrate that the volume to outcomes curve for HPB operations should be assessed more holistically and that patients can safely... 2/28/2021
Hadas Alfandary, Orly Haskin, Ori Goldberg, Amit Dagan, Yael Borovitz, Shelly Levi, Miriam Davidovits, Tomer Erlich, Daniel Landau, Oren Pleniceanu Is the prognosis of congenital single functioning kidney benign? A population-based study CONCLUSIONS: This large population-based study documents a significant risk for KI among adolescents with SFK. Obesity represents a major modifiable risk factor for KI, implicating the need for closer follow-up in this group during childhood. 2/23/2021
Marianna V Papageorge, Susanna W L de Geus, Alison P Woods, Sing Chau Ng, Frederick T Drake, Michael R Cassidy, David B McAneny, Jennifer F Tseng, Teviah E Sachs Undertreatment of Gallbladder Cancer: A Nationwide Analysis CONCLUSIONS: Re-resection for gallbladder cancer is associated with improved survival but remains underused, particularly for early-stage disease. 2/10/2021
Teviah E Sachs, Jennifer F Tseng Landmark Series in Pancreatic Tumors: Anastomotic Techniques and Route of Reconstruction CONCLUSION: While clear consensus on how best to reconstruct the anatomy after pancreaticoduodenectomy has not yet been reached, we present the following review in the hope of providing some understanding of the literature for the pancreatic surgeon. 2/7/2021
Michael R Poulson, B Aldana Blanco, Alaina D Geary, Kelly M Kenzik, David B McAneny, Jennifer F Tseng, Teviah E Sachs The role of racial segregation in treatment and outcomes among patients with hepatocellular carcinoma CONCLUSIONS: Our data illustrate that structural racism in the form racial segregation has a significant impact on racial disparities in the treatment of HCC. Urban and health policy changes can potentially reduce disparities in HCC outcomes. 2/4/2021
Camilla Gomes, Patrick Tivnan, David McAneny, Jennifer F Tseng, Jaroslaw Tkacz, Teviah E Sachs Choledochal Cyst or Benign Biliary Dilation: Is Resection Always Necessary? CONCLUSION: A radiographic diagnosis of choledochal cyst in older adults is likely a different entity than those diagnosed in childhood. Close surveillance of these biliary duct anomalies in older adults may be a better option than resection and reconstruction with the associated risks of long-term ... 1/23/2021
Laura H Rosenberger, Samantha M Thomas, Suniti N Nimbkar, Tina J Hieken, Kandice K Ludwig, Lisa K Jacobs, Megan E Miller, Kristalyn K Gallagher, Jasmine Wong, Heather B Neuman, Jennifer Tseng, Taryn E Hassinger, Tari A King, James W Jakub Contemporary Multi-Institutional Cohort of 550 Cases of Phyllodes Tumors (2007-2017) Demonstrates a Need for More Individualized Margin Guidelines CONCLUSION: In current practice, many patients are managed outside of current guidelines. For the entire cohort, a wider margin width was not associated with a reduced risk of LR. We do not recommend re-excision of a negative margin for benign PT, regardless of margin width, as a progressively wider... 12/10/2020
Alberto Guillén, José Martínez, Juan Miguel Carceller, Luis Javier Herrera A Comparative Analysis of Machine Learning Techniques for Muon Count in UHECR Extensive Air-Showers The main goal of this work is to adapt a Physics problem to the Machine Learning (ML) domain and to compare several techniques to solve it. The problem consists of how to perform muon count from the signal registered by particle detectors which record a mix of electromagnetic and muonic signals. Fin... 12/8/2020
Luis Javier Herrera, Carlos José Todero Peixoto, Oresti Baños, Juan Miguel Carceller, Francisco Carrillo, Alberto Guillén Composition Classification of Ultra-High Energy Cosmic Rays The study of cosmic rays remains as one of the most challenging research fields in Physics. From the many questions still open in this area, knowledge of the type of primary for each event remains as one of the most important issues. All of the cosmic rays observatories have been trying to solve thi... 12/8/2020
Susanna W L de Geus, Krista J Hachey, Jacob D Nudel, Sing Chau Ng, David B McAneny, Joshua D Davies, Jennifer F Tseng, Teviah E Sachs Volume of Pancreas-Adjacent Operations Favorably Influences Pancreaticoduodenectomy Outcomes at Lower Volume Pancreas Centers CONCLUSIONS: PD outcomes at low-volume centers that have experience with complex cancer operations near the pancreas are similar to PD outcomes at hospitals with high PD volume. MVH provides a model for PD outcomes to improve quality and access for patients who cannot, or choose not to, receive thei... 12/4/2020
Alena Opálková Šišková, Tomáš Dvorák, Tímea Šimonová Baranyaiová, Erik Šimon, Anita Eckstein Andicsová, Helena Švajdlenková, Andrej Opálek, Peter Krížik, Martin Nosko Simple and Eco-Friendly Route from Agro-Food Waste to Water Pollutants Removal The current study reflects the demand to mitigate the environmental issues caused by the waste from the agriculture and food industry. The crops that do not meet the supply chain requirements and waste from their processing are overfilling landfills. The mentioned wastes contain cellulose, which is ... 12/2/2020
Barbara Aldana Blanco, Michael Poulson, Kelly M Kenzik, David B McAneny, Jennifer F Tseng, Teviah E Sachs The Impact of Residential Segregation on Pancreatic Cancer Diagnosis, Treatment, and Mortality CONCLUSIONS: Disparities in advanced-stage disease at diagnosis, surgery for localized disease, and overall survival are directly related to the degree of residential segregation, a proxy for structural racism. In searching for solutions to this problem, it is important to account for the historical... 11/2/2020
María M Pérez, Alvaro Della Bona, Francisco Carrillo-Pérez, Diana Dudea, Oscar E Pecho, Luis Javier Herrera Does background color influence visual thresholds? CONCLUSIONS: The perceptibility and acceptability thresholds in dentistry are affected by the color difference metrics and by the background color. 9/22/2020
Kathryn I Sunthankar, Kevin N Griffith, Stephanie D Talutis, Amy K Rosen, David B McAneny, Matthew H Kulke, Jennifer F Tseng, Teviah E Sachs Cancer stage at presentation for incarcerated patients at a single urban tertiary care center Patients who are incarcerated are a vulnerable patient population and may suffer from less access to routine cancer screenings compared to their non-incarcerated counterparts. Therefore, a thorough evaluation of potential differences in cancer diagnosis staging is needed. We sought to examine whethe... 9/15/2020
Rachel M Lee, Cecilia G Ethun, Mohammad Y Zaidi, Thuy B Tran, George A Poultsides, Valerie P Grignol, John H Howard, Meena Bedi, T Clark Gamblin, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley A Krasnick, Ryan C Fields, Shervin V Oskouei, David K Monson, Nickolas B Reimer, Shishir K Maithel, Kenneth Cardona A closer look at the natural history and recurrence patterns of high-grade truncal/extremity leiomyosarcomas: A multi-institutional analysis from the US Sarcoma Collaborative CONCLUSIONS: In our cohort, patients with LMS have a low local recurrence rate (12-15%) and modest distant recurrence rate (29-35%). However, LMS patients had no improvement in local control or long-term outcomes with radiation. The value of radiation in these patients merits further investigation. 9/6/2020
Susanna W L de Geus, Sameer Hirji, Krista J Hachey, Teviah E Sachs, Kei Suzuki, Sing Chau Ng, Scott Swanson, Virginia R Litle, Thomas D'Amico, Jennifer F Tseng Lymphadenectomy and Survival After Neoadjuvant Chemoradiation for Esophageal Adenocarcinoma: Is More Better? CONCLUSIONS: After neoadjuvant chemoradiation, resection of 25 or more lymph nodes was associated with longer median survival. Prospective trials are warranted to determine the optimal nodal yield after neoadjuvant chemoradiation. 9/3/2020
Kurt S Schultz, Donald T Hess, Teviah E Sachs, Jennifer F Tseng, Luise I M Pernar A Structured Mentorship Elective Deepens Personal Connections and Increases Scholarly Achievements of Senior Surgery Residents CONCLUSIONS: A structured apprenticeship rotation allowed for closer relationships with attending surgeons and increased the scholarly achievement of PGY-4 surgery residents. We provide an example of how to incorporate a successful elective rotation into the surgery curriculum that strengthens resid... 9/1/2020
Jared A Shenson, George S Liu, Joyce Farrell, Nikolas H Blevins Multispectral Imaging for Automated Tissue Identification of Normal Human Surgical Specimens CONCLUSIONS: A deep learning model using multispectral imaging outperformed a similar model and surgical residents using traditional white-light imaging at the task of classifying normal human head and neck tissue ex vivo. These results suggest that multispectral imaging can enhance surgical vision ... 8/26/2020
Michael Poulson, Alaina Geary, Chandler Annesi, Lisa Allee, Kelly Kenzik, Sabrina Sanchez, Jennifer Tseng, Tracey Dechert National Disparities in COVID-19 Outcomes between Black and White Americans CONCLUSION: Despite the initial descriptions of COVID-19 being a disease that affects all individuals, regardless of station, our data demonstrate the differential racial effects in the United States. This current pandemic reinforces the need to assess the unequal effects of crises on disadvantaged ... 8/12/2020
Kurt S Schultz, Susanna W L de Geus, Teviah E Sachs, Ryan B Morgan, Sing Chau Ng, David McAneny, Jennifer F Tseng Influence of race and sociodemographic factors on declining resection for gastric cancer: A national study CONCLUSIONS: Racial and sociodemographic disparities exist in the treatment of potentially curable gastric cancer, with patients who decline recommended surgery suffering worse overall survival. 8/8/2020
Erin A Strong, Sandra H Park, Cecilia G Ethun, Bonnie Chow, David King, Meena Bedi, John Charlson, Harveshp Mogal, Susan Tsai, Kathleen Christians, Thuy B Tran, George Poultsides, Valerie Grignol, J Harrison Howard, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Darren Cullinan, Ryan C Fields, T Clark Gamblin, Kenneth Cardona, Callisia N Clarke High neutrophil-lymphocyte ratio is not independently associated with worse survival or recurrence in patients with extremity soft tissue sarcoma CONCLUSION: Tumor inflammation as measured by high pretreatment neutrophil-lymphocyte ratio was not independently associated with overall survival in patients undergoing resection for extremity soft tissue sarcomas. 8/2/2020
Daniel H Landau, Béatrice S Hasler, Doron Friedman Virtual Embodiment Using 180° Stereoscopic Video One of the most exciting possibilities of virtual reality is inducing in participants the illusion of owning a virtual body. This has become an established methodological paradigm allowing the study of the psychological and neural correlates of various scenarios that are impossible in the real world... 8/1/2020
Jason T Wiseman, Cecilia G Ethun, Jordan M Cloyd, Rita Shelby, Lorena Suarez-Kelly, Thuy Tran, George Poultsides, Harveshp Mogal, Callisia Clarke, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley Krasnick, Ryan Fields, Kara Vande Walle, Sean Ronnekleiv-Kelly, John Harrison Howard, Kenneth Cardona, Valerie Grignol Analysis of textbook outcomes among patients undergoing resection of retroperitoneal sarcoma: A multi-institutional analysis of the US Sarcoma Collaborative CONCLUSIONS: Among patients undergoing resection for RPS, failure to achieve TO is common and associated with significantly worse survival. The use of TO may inform patient expectations and serve as a measure for patient-level hospital performance. 7/23/2020
Stephanie D Talutis, Susanna W L de Geus, Alik Farber, Scott R Levin, Thomas W Cheng, Teviah E Sachs, Jennifer F Tseng, Jeffrey J Siracuse Contemporary Analysis of Senior Level Case Volume Variation between Traditional Vascular Surgery Fellows and Integrated Vascular Surgery Chief Residents CONCLUSIONS: Although both pathways graduate trainees with a similar overall surgical experience, 5 + 2 trainees log significantly more "Senior" cases. Further studies investigating potential variation in operative autonomy between both pathways are necessary. 7/10/2020
Sherif Aly, Stephanie D Talutis, Aaron P Richman, Donald T Hess, David McAneny, Jennifer F Tseng, F Thurston Drake The Boston Medical Center Coronavirus Disease 2019 (COVID-19) Procedure Team: Optimizing the surgeon's role in pandemic care at a safety-net hospital CONCLUSION: Procedural complication rate was less than rates reported in the literature. The team saved approximately 192 hours of work that could be redirected to other patient care needs. In times of crisis, redeployment of surgeons (who arguably have the most procedural experience) into procedura... 7/7/2020
Jörg Bohlen, Tomáš Dvořák, Vlastimil Šlechta, Vendula Šlechtová Resolving an unnoticed diversity within the Schistura robertsi species complex (Teleostei: Nemacheilidae) using molecules and morphology The Schistura robertsi species complex is a group of freshwater fish inhabiting streams in southeast Myanmar as well as in western and southern Thailand. In southern Thailand, the distribution exceeds the biogeographically important 'Surat Thani - Krabi line'. The complex is believed to include five... 6/21/2020
Daniel Landau, Muhammad H Assadi, Rawan Abu Hilal, Yu Chen, Ralph Rabkin, Yael Segev SOCS2 Silencing Improves Somatic Growth without Worsening Kidney Function in CKD CONCLUSIONS: CKD-related growth retardation is overcome by SOCS2 silencing, in association with increased hepatic STAT5 phosphorylation. Renal insufficiency is not worsened by SOCS2 absence, as kidney GHR and STAT5 are not upregulated. This may be due to elevated kidney proinflammatory cytokines and... 6/17/2020
Mayya Volodarskaya, A Blake Tucker, Jennifer Tseng Medical Student Research in Surgery: From Abstract Presentation to Publication CONCLUSIONS: Forty-six percent of medical student abstract presentations at the ACS Clinical Congress were converted to peer-reviewed publications. While it is encouraging that the ACS Clinical Congress is a productive forum to showcase medical student scholarly activity, more can be done to encoura... 6/17/2020
Hisham Mehanna, John C Hardman, Jared A Shenson, Ahmad K Abou-Foul, Michael C Topf, Mohammad AlFalasi, Jason Y K Chan, Pankaj Chaturvedi, Velda Ling Yu Chow, Andreas Dietz, Johannes J Fagan, Christian Godballe, Wojciech Golusiński, Akihiro Homma, Sefik Hosal, N Gopalakrishna Iyer, Cyrus Kerawala, Yoon Woo Koh, Anna Konney, Luiz P Kowalski, Dennis Kraus, Moni A Kuriakose, Efthymios Kyrodimos, Stephen Y Lai, C Rene Leemans, Paul Lennon, Lisa Licitra, Pei-Jen Lou, Bernard Lyons, Haitham Mirghani, Anthonny C Nichols, Vinidh Paleri, Benedict J Panizza, Pablo Parente Arias, Mihir R Patel, Cesare Piazza, Danny Rischin, Alvaro Sanabria, Robert P Takes, David J Thomson, Ravindra Uppaluri, Yu Wang, Sue S Yom, Yi-Ming Zhu, Sandro V Porceddu, John R de Almeida, Chrisian Simon, F Christopher Holsinger Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic: an international consensus The speed and scale of the global COVID-19 pandemic has resulted in unprecedented pressures on health services worldwide, requiring new methods of service delivery during the health crisis. In the setting of severe resource constraint and high risk of infection to patients and clinicians, there is a... 6/15/2020
Jennifer Tseng How Has COVID-19 Affected the Costs of the Surgical Fellowship Interview Process? CONCLUSIONS: The COVID-19 public health crisis has had a significant impact on surgical education, including how selection is conducted. Virtual recruitment has the potential for cost savings but should continue to be refined. This is an opportune time to innovate and rethink how to recruit prospect... 6/9/2020
Jared A Shenson, Stephen Marcott, Karuna Dewan, Yu-Jin Lee, Edward R Mariano, Davud B Sirjani Utility of videolaryngoscopy for diagnostic and therapeutic interventions in head and neck surgery BACKGROUND: Videolaryngoscopy is commonly used by anesthesiologists to manage difficult airways. Recently otolaryngologists have reported use in select procedures; to date there is limited evaluation in head and neck surgery. 6/8/2020
Susanna W L de Geus, Alik Farber, Scott Levin, Sarah J Carlson, Thomas W Cheng, Jennifer F Tseng, Jeffrey J Siracuse Perioperative Outcomes of Carotid Interventions in Octogenarians CONCLUSIONS: Outcomes of CEA and CAS were similar in octogenarians. Risk factors for worse intervention outcomes were identified, which may guide risk-benefit discussions and shared decision-making. 6/7/2020
Laura H Rosenberger, Samantha M Thomas, Suniti N Nimbkar, Tina J Hieken, Kandice K Ludwig, Lisa K Jacobs, Megan E Miller, Kristalyn K Gallagher, Jasmine Wong, Heather B Neuman, Jennifer Tseng, Taryn E Hassinger, James W Jakub Germline Genetic Mutations in a Multi-center Contemporary Cohort of 550 Phyllodes Tumors: An Opportunity for Expanded Multi-gene Panel Testing CONCLUSIONS: Very few women with PT undergo germline testing; however, in those selected for testing, a deleterious mutation was identified in ~ 10%. Multigene testing of a PT cohort would present an opportunity to discover the true incidence of germline mutations in PT patients. 6/7/2020
Darryl Schuitevoerder, Charles C Vining, Jennifer Tseng Adjuvant Therapy for Cutaneous Melanoma This article presents the current data supporting adjuvant therapy for patients with cutaneous melanoma. With the recent development of novel immunotherapy agents as well as targeted therapy, there are strong data to support the use of these therapies in patients at high risk of developing recurrent... 6/3/2020
Timothy Feeney, Christine Park, Frederick Godley, Michael Cassidy, Teviah Sachs, David McAneny, Jennifer F Tseng, Frederick Thurston Drake Provider-patient Language Discordance and Cancer Operations: Outcomes from a Single Center Linked to a State Vital Statistics Registry CONCLUSIONS: We found no association between language and outcomes after cancer operations. This lack of difference may reflect local efficacy at treating non-English-speaking patients, and health systems with fewer services for LEP patients might show different results. 6/1/2020
Jennifer Tseng Learning theories and principles in surgical education and technical learning What is important to think about in surgical education and technical skills training? Technical skills training is grounded in social cognitive theory and the concepts of modeling and self-efficacy. Cognitive and nontechnical learning is critical to supplement the overall proficiency of the surgical... 5/23/2020
Charles C Vining, Oliver S Eng, Melissa E Hogg, Darryl Schuitevoerder, Rebecca S Silverman, Katharine A Yao, David J Winchester, Kevin K Roggin, Mark S Talamonti, Mitchell C Posner, Kiran K Turaga, Jennifer Tseng Virtual Surgical Fellowship Recruitment During COVID-19 and Its Implications for Resident/Fellow Recruitment in the Future CONCLUSIONS: Current circumstances related to the COVID-19 pandemic require fellowship programs to adapt and conduct virtual interviews. Our report describes the successful implementation of a virtual interview process. This report describes the technical steps and pitfalls of organizing such an int... 5/20/2020
Adnan S Hussaini, Christine M Clark, Atur A Patel, Mark E Russo, Stanley H Chia, Bruce J Davidson, Sonya Malekzadeh Management of Adult Inpatient Otolaryngologic Consultations During the COVID-19 Pandemic: A Proposed Tier-Based Triage System The coronavirus disease 2019 (COVID-19) pandemic has placed tremendous strain on health care systems, leading to unprecedented challenges and obstacles in the delivery of patient care. Otolaryngologists are frequently called on for inpatient consultations for an array of pathologies, ranging from ch... 5/20/2020
Adnan S Hussaini, Christine M Clark, Timothy R DeKlotz Perioperative Considerations in Endoscopic Skull Base Surgery PURPOSE OF THE REVIEW: Present an overview of perioperative considerations specific to endoscopic skull base surgery necessary to maximize successful outcomes. 5/19/2020
Sammy Moussly, Jacqueline Kropf, Nawid Sarwari, Jose Sarriera, Steve Carlan, Mario Madruga Successful Use of Adjunctive Red Blood Cell Exchange Therapy for Treatment of an Acute Hemolytic Reaction After ABO-Incompatible Red Blood Cell Transfusion An acute hemolytic transfusion reaction is a potentially fatal complication resulting from the transfusion of mismatched blood products. Symptoms vary from mild to severe depending on how much incompatible antigen was transfused and the nature of the recipient's antibodies. There is no consensus agr... 4/18/2020
Michael C Topf, Jared A Shenson, F Christopher Holsinger, Samuel H Wald, Lisa J Cianfichi, Eben L Rosenthal, John B Sunwoo Framework for prioritizing head and neck surgery during the COVID-19 pandemic The COVID-19 pandemic has placed an extraordinary demand on the United States health care system. Many institutions have canceled elective and non-urgent procedures to conserve resources and limit exposure. While operational definitions of elective and urgent categories exist, there is a degree of s... 4/17/2020
Dao M Nguyen, Inderpal S Sarkaria, Chao Song, Rishindra M Reddy, Nestor Villamizar, Luis J Herrera, Lu Shi, Emelline Liu, David Rice, Daniel S Oh Clinical and economic comparative effectiveness of robotic-assisted, video-assisted thoracoscopic, and open lobectomy CONCLUSIONS: During the study period, the utilization of RL increased substantially and was associated with improved perioperative outcomes compared with VL and OL. When annual hospital volume was >25 cases, these clinical advantages persisted and there was no significant cost difference between RL,... 4/11/2020
Jennifer F Tseng We are All Asian: Society of Asian Academic Surgeons Presidential Address This 2019 Presidential Address for the Society of Asian Academic Surgeons was delivered on September 27, 2019. Using anecdotes from her upbringing, Dr. Jennifer Tseng offers a visionary perspective on belonging and inclusivity in academic surgery. She concludes with practical strategies for success ... 4/9/2020
Jörg Bohlen, Tomáš Dvořák, Vlastimil Šlechta, Vendula Šlechtová Sea water shaping the freshwater biota: Hidden diversity and biogeographic history in the Paracanthocobitis zonalternans species complex (Teleostei: Nemacheilidae) in western Southeast Asia Western Southeast Asia is hosting one of the world's most diverse faunas, and one of the reasons for this huge diversity is the complex geologic past of the area, increasing the frequency of isolation and expansion events over evolutionary time scale. As an example case, the present study reveals th... 4/6/2020
Rita D Shelby, Lorena P Suarez-Kelly, Peter Y Yu, Tasha M Hughes, Cecilia G Ethun, Thuy B Tran, George Poultsides, David M King, Meena Bedi, Harveshp Mogal, Callisia Clarke, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley A Krasnick, Ryan C Fields, Raphael E Pollock, J Harrison Howard, Kenneth Cardona, Valerie Grignol Neoadjuvant radiation improves margin-negative resection rates in extremity sarcoma but not survival CONCLUSION: In this large study, radiotherapy improved limb salvage rates and decreased local recurrences. Receipt of NAR achieves more margin-negative resections however this did not improve local recurrence or survival rates over. 4/2/2020
Raffit Hassan, George R Blumenschein, Kathleen N Moore, Alessandro D Santin, Hedy L Kindler, John J Nemunaitis, Shelly M Seward, Anish Thomas, Stella K Kim, Prabhu Rajagopalan, Annette O Walter, Dirk Laurent, Barrett H Childs, Nenad Sarapa, Cem Elbi, Johanna C Bendell First-in-Human, Multicenter, Phase I Dose-Escalation and Expansion Study of Anti-Mesothelin Antibody-Drug Conjugate Anetumab Ravtansine in Advanced or Metastatic Solid Tumors CONCLUSION: Anetumab ravtansine exhibited a manageable safety and favorable pharmacokinetic profile with encouraging preliminary antitumor activity in heavily pretreated patients with mesothelin-expressing solid tumors. The results allowed for the determination of recommended doses, schedules, and p... 3/28/2020
Jessica H Maxwell, James A Randall, Sarah M Dermody, Adnan S Hussaini, Hamsini Rao, Ajay S Nathan, Sonya Malekzadeh, Jamie R Litvack Gender and compensation among surgical specialties in the Veterans Health Administration CONCLUSION: Female gender significantly predicted lower salary among VAMC surgeons, however within each surgical specialty, there was no significant gender pay gap. 3/19/2020
Meena Bedi, Cecilia G Ethun, John Charlson, Thuy B Tran, George Poultsides, Valerie Grignol, J Harrison Howard, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Darren Cullinan, Ryan C Fields, Kenneth Cardona, David M King Is a Nomogram Able to Predict Postoperative Wound Complications in Localized Soft-tissue Sarcomas of the Extremity? CONCLUSIONS: We found that age, BMI, tumor location, and timing of radiation are associated with the risk of wound complications. Based on these factors, a validated nomogram has been established that can provide an individualized prediction of wound complications in patients with a resected soft-ti... 3/14/2020
Vinay K Puduvalli, Jing Wu, Ying Yuan, Terri S Armstrong, Elizabeth Vera, Jimin Wu, Jihong Xu, Pierre Giglio, Howard Colman, Tobias Walbert, Jeffrey Raizer, Morris D Groves, David Tran, Fabio Iwamoto, Nicholas Avgeropoulos, Nina Paleologos, Karen Fink, David Peereboom, Marc Chamberlain, Ryan Merrell, Marta Penas Prado, W K Alfred Yung, Mark R Gilbert A Bayesian adaptive randomized phase II multicenter trial of bevacizumab with or without vorinostat in adults with recurrent glioblastoma CONCLUSIONS: Bevacizumab combined with vorinostat did not yield improvement in PFS or OS or clinical benefit compared with bevacizumab alone or a clinical benefit in adults with recurrent GBM. This trial is the first to test a Bayesian adaptive design with adaptive randomization and Bayesian continu... 3/14/2020
Emily J Ross, Chelsea H Wiener, Diane Robinson, Jeffrey E Cassisi Optimizing Community and Hospital Services Using the Cancer Support Source Program CONCLUSIONS: Three factors are proposed as CSS subscales to guide referral and coordinate services: Emotional Distress/Patient and Family Counselor, Physical Health Concerns/Medical Care Provider, and Resource Needs/Case Management-Clinical Social Worker. The clinical utility of these referral subsc... 3/5/2020
Susanna W L de Geus, Teviah E Sachs, Jennifer F Tseng Big Data vs. Clinical Trials in HPB Surgery Randomized controlled clinical trials (RCTs) are at the heart of "evidence-based" medicine. However, in surgical practice, RCTs remain uncommon. Conducting well-designed RCTs for surgical procedures is often challenged by inadequate recruitment accrual, blinding, or standardization of the surgical p... 2/21/2020
Hava Peretz, Michael Korostishevsky, David M Steinberg, Mustafa Kabha, Sali Usher, Irit Krause, Hannah Shalev, Daniel Landau, David Levartovsky An ancestral variant causing type I xanthinuria in Turkmen and Arab families is predicted to prevail in the Afro-Asian stone-forming belt Classical xanthinuria is a rare autosomal recessive metabolic disorder characterized by lack of xanthine dehydrogenase activity that often manifests as xanthine urolithiasis and risk of drug toxicity. Variants in the XDH or HMCS gene underlie classical xanthinuria type I and type II, respectively. H... 2/20/2020
Jonathan Strosberg, Nobumasa Mizuno, Toshihiko Doi, Enrique Grande, Jean-Pierre Delord, Ronnie Shapira-Frommer, Emily Bergsland, Manisha Shah, Marwan Fakih, Shunji Takahashi, Sarina A Piha-Paul, Bert O'Neil, Sajeve Thomas, Martijn P Lolkema, Menghui Chen, Nageatte Ibrahim, Kevin Norwood, Julien Hadoux Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Neuroendocrine Tumors: Results From the Phase II KEYNOTE-158 Study CONCLUSIONS: Pembrolizumab monotherapy showed limited antitumor activity and manageable safety in patients with previously treated advanced well-differentiated NETs. 1/26/2020
Clint P Woodward, Thomas Rüther, Campbell J Coghlan, Timothy W Jones, Yanek Hebting, Richard L Cordiner, Ryan E Dawson, Diane E J E Robinson, Craig M Forsyth, Gregory J Wilson Tetracarboxylate Bis-Bipyridine Ruthenium Dyes: Synthesis, Structural and Electronic Characterisation The preparation of ruthenium complexes with novel 2,2'-bipyridine (bpy) ligands bearing four carboxylic acid groups was investigated with a view to creating dyes containing more than two potential anchoring groups per bpy unit for attachment to a titania surface. Synthetic challenges are encountered... 1/18/2020
Hadas Alfandary, Choni Rinat, Evgenia Gurevich, Israel Eisenstein, Ori Goldberg, Nesia Kropach, Daniel Landau Hemolytic Uremic Syndrome: A Contemporary Pediatric Experience CONCLUSIONS: HUS incidence is lower in Israel than in most countries, especially because STEC-HUS is very rare. aHUS is the largest defined etiological group; some distinctive characteristics were identified that could facilitate its diagnosis. The current classification system leaves a high rate of... 1/15/2020
Benjamin D Smith, Xiudong Lei, Kevin Diao, Ying Xu, Yu Shen, Grace L Smith, Sharon H Giordano, Sarah M DeSnyder, Kelly K Hunt, Mediget Teshome, Reshma Jagsi, Simona F Shaitelman, Susan K Peterson, Cameron W Swanick Effect of Surgeon Factors on Long-Term Patient-Reported Outcomes After Breast-Conserving Therapy in Older Breast Cancer Survivors CONCLUSIONS: Specialized surgical oncology training is associated with improved long-term patient-reported outcomes. These findings underscore the value of specialized training and may be useful to patients choosing their care team. 1/10/2020
Eric Rondeau, Spero R Cataland, Imad Al-Dakkak, Benjamin Miller, Nicholas J A Webb, Daniel Landau Eculizumab Safety: Five-Year Experience From the Global Atypical Hemolytic Uremic Syndrome Registry CONCLUSION: In this large observational dataset covering 5 years of registry enrollment, no new safety concerns were identified for adult or pediatric eculizumab-treated patients with aHUS, confirming a positive benefit-risk profile in a real-world setting. 1/1/2020
Juan M Galvez, Daniel Castillo-Secilla, Luis J Herrera, Olga Valenzuela, Octavio Caba, Jose C Prados, Francisco M Ortuno, Ignacio Rojas Towards Improving Skin Cancer Diagnosis by Integrating Microarray and RNA-Seq Datasets Many clinical studies have revealed the high biological similarities existing among different skin pathological states. These similarities create difficulties in the efficient diagnosis of skin cancer, and encourage to study and design new intelligent clinical decision support systems. In this sense... 12/25/2019
James R Howe, Nipun B Merchant, Claudius Conrad, Xavier M Keutgen, Julie Hallet, Jeffrey A Drebin, Rebecca M Minter, Terry C Lairmore, Jennifer F Tseng, Herbert J Zeh, Steven K Libutti, Gagandeep Singh, Jeffrey E Lee, Thomas A Hope, Michelle K Kim, Yusuf Menda, Thorvardur R Halfdanarson, Jennifer A Chan, Rodney F Pommier The North American Neuroendocrine Tumor Society Consensus Paper on the Surgical Management of Pancreatic Neuroendocrine Tumors This manuscript is the result of the North American Neuroendocrine Tumor Society consensus conference on the surgical management of pancreatic neuroendocrine tumors from July 19 to 20, 2018. The group reviewed a series of questions of specific interest to surgeons taking care of patients with pancre... 12/20/2019
Bar Rotem-Grunbaum, Daniel Landau Genetic renal disease classification by hormonal axes The kidneys, which regulate many homeostatic pathways, are also a major endocrinological target organ. Many genetic renal diseases can be classified according to the affected protein along such endocrinological pathways. In this review, we examine the hypothesis that a more severe phenotype is expec... 12/13/2019
Igor Richter, Tomas Jirasek Eva Cermakova Jiri Bartos Tomas Büchler Josef Dvorak Expression and prognostic significance of programmed death-ligand 1 (PD-L1) in Merkel cell carcinoma CONCLUSIONS: PD-L1 positivity was found in 61.5% of patients with MCC. No prognostic significance of PD-L1 expression for OS was demonstrated. 12/2/2019
Shelly Kagan, Itzhak Levy, Liat Ashkenazi-Hoffnung, Alex Lowenthal, Robert E Goldstein, Daniel Landau, Oded Scheuerman Q Fever and Kingella kingae Endocarditis in a Toddler: A Rare Coinfection Case A toddler after tetralogy of Fallot graft repair in infancy was diagnosed with endocarditis. Blood cultures were positive for Kingella kingae and serology was positive Coxiella burnetii. He was treated medically and surgically. A postoperative specimen polymerase chain reaction confirmed a coinfecti... 11/19/2019
Susanna W L de Geus, Alaina D Geary, Nkiruka Arinze, Sing Chau Ng, Cullen O Carter, Teviah E Sachs, Jason F Hall, Donald T Hess, Jennifer F Tseng, Luise I M Pernar Resident involvement in minimally-invasive vs. open procedures CONCLUSIONS: The results of this study suggest that resident participation has a similar impact on surgical outcomes during laparoscopic and open surgery, and is generally safe. 11/15/2019
Max Drabkin, Yuval Yogev, Lior Zeller, Raz Zarivach, Ran Zalk, Daniel Halperin, Ohad Wormser, Evgenia Gurevich, Daniel Landau, Rotem Kadir, Yonatan Perez, Ohad S Birk Hyperuricemia and gout caused by missense mutation in d-lactate dehydrogenase Gout is caused by deposition of monosodium urate crystals in joints when plasma uric acid levels are chronically elevated beyond the saturation threshold, mostly due to renal underexcretion of uric acid. Although molecular pathways of this underexcretion have been elucidated, its etiology remains mo... 10/23/2019
Jennifer Tseng, Mitchell C Posner For Gastroesophageal Junction Cancers, Does an "Esophageal" or "Gastric" Surgical Approach Offer Better Perioperative and Oncologic Outcomes? CONCLUSIONS: The proximal and distant extent of the tumor based on Siewert type classification greatly influences choice of operation. Overall survival rates and surgical outcomes are comparable, and surgical approach should be dictated by patient factors. 10/2/2019
Yossi Hasson, Noa Schori-Eyal, Daniel Landau, Béatrice S Hasler, Jonathan Levy, Doron Friedman, Eran Halperin The enemy's gaze: Immersive virtual environments enhance peace promoting attitudes and emotions in violent intergroup conflicts Perspective-taking is essential for improving intergroup relations. However, it is difficult to implement, especially in violent conflicts. Given that immersive virtual reality (VR) can simulate various points of view (POV), we examined whether it can lead to beneficial outcomes by promoting outgrou... 9/12/2019
Malcolm H Squires, Cecilia G Ethun, Lorena P Suarez-Kelly, Peter Y Yu, Tasha M Hughes, Rita D Shelby, Thuy B Tran, George Poultsides, John Charlson, T Clark Gamblin, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley A Krasnick, Ryan C Fields, Raphael E Pollock, Valerie Grignol, Kenneth Cardona, J Harrison Howard Trends in the Use of Adjuvant Chemotherapy for High-Grade Truncal and Extremity Soft Tissue Sarcomas CONCLUSIONS: Rates of adjuvant chemotherapy for resected high-grade truncal or extremity STS have not decreased over time within the U.S. Sarcoma Collaborative, despite RCT data suggesting a lack of efficacy. In this retrospective multi-institutional analysis, adjuvant chemotherapy was not associate... 9/9/2019
Olga Kantor, Jean Bao, Nora Jaskowiak, Katherine Yao, Jennifer Tseng The Prognostic Value of the AJCC 8th Edition Staging System for Patients Undergoing Neoadjuvant Chemotherapy for Breast Cancer CONCLUSIONS: Sixty-five percent of patients have a shift in clinical stage in the AJCC 8th edition. AJCC 8th edition staging has better predictive value for OS than 7th edition staging. While validation of these findings with an independent dataset is needed, 8th edition staging will help improve pr... 8/4/2019
Mohammad Y Zaidi, Cecilia G Ethun, Thuy B Tran, George Poultsides, Valerie P Grignol, J Harrison Howard, Meena Bedi, Harveshp Mogal, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Brad Krasnick, Ryan C Fields, Shervin Oskouei, Nickolas Reimer, David Monson, Shishir K Maithel, Kenneth Cardona Assessing the Role of Neoadjuvant Chemotherapy in Primary High-Risk Truncal/Extremity Soft Tissue Sarcomas: An Analysis of the Multi-institutional U.S. Sarcoma Collaborative CONCLUSION: For the patients with high-grade STS, NCT was associated with improved RFS and OS when tumors were 10 cm or larger and located in the extremity. However, no histiotype-specific advantage was identified. Future studies assessing the efficacy of NCT may consider focusing on these patients,... 7/26/2019
Timothy Feeney, Michael Cassidy, Yorghos Tripodis, David McAneny, Maureen Kavanah, Teviah Sachs, Jennifer F Tseng, Frederick Thurston Drake Correction to: Association of Primary Language with Outcomes After Operations Typically Performed to Treat Cancer: Analysis of a Statewide Database In the original article, there were errors in Table 1 that were not in accordance with requirements set by the Healthcare Cost and Utilization Project (HCUP) Data Use Agreement that apply to this article. Following is the corrected Table 1. 7/18/2019
Patrick B Schwartz, Kara Vande Walle, Emily R Winslow, Cecilia G Ethun, Thuy B Tran, George Poultsides, Jennifer Tseng, Kevin Roggin, Valerie Grignol, John Harrison Howard, Bradley A Krasnick, Ryan C Fields, Harveshp Mogal, Callisia N Clarke, Rebecca Senehi, Konstantinos Votanopoulos, Kenneth Cardona, Daniel E Abbott Predictors of Disease-Free and Overall Survival in Retroperitoneal Sarcomas: A Modern 16-Year Multi-Institutional Study from the United States Sarcoma Collaboration (USSC) CONCLUSIONS: The strongest predictors of disease-free and overall survival are tumor-specific characteristics, while surgical factors are less impactful. Nonsurgical therapies are not associated with improved outcomes despite persistent interest and utilization. Complete macroscopic resection (R0/R1... 7/9/2019
Konstantinos Chouliaras, Rebecca Senehi, Cecilia G Ethun, George Poultsides, Thuy Tran, Valerie Grignol, Thomas Clark Gamblin, Kevin K Roggin, Jennifer Tseng, Ryan C Fields, Sharon M Weber, Gregory B Russell, Edward A Levine, Kenneth Cardona, Konstantinos Votanopoulos Recurrence patterns after resection of retroperitoneal sarcomas: An eight-institution study from the US Sarcoma Collaborative CONCLUSIONS: Recurrence after resection of RPS occurs in more than half of patients independently of resection status or perioperative chemotherapy and is equally distributed between locoregional and distant sites. Recurrence is primarily related to tumor biology and is associated with a significant... 6/28/2019
Praveen Sridhar, Priya Misir, Hyunjee Kwak, Susanna Wl deGeus, Frederick T Drake, Michael R Cassidy, David A McAneny, Jennifer F Tseng, Teviah E Sachs Impact of Race, Insurance Status, and Primary Language on Presentation, Treatment, and Outcomes of Patients with Pancreatic Adenocarcinoma at a Safety-Net Hospital CONCLUSIONS: There were no statistically significant relationships between examined social determinants of health and use of operation or perioperative therapy. Patients treated at an urban safety-net hospital with a focus on vulnerable patient populations are able to provide outcomes similar to nat... 6/19/2019
Timothy Feeney, Michael Cassidy, Yorghos Tripodis, David McAneny, Maureen Kavanah, Teviah Sachs, Jennifer F Tseng, Frederick Thurston Drake Association of Primary Language with Outcomes After Operations Typically Performed to Treat Cancer: Analysis of a Statewide Database CONCLUSIONS: No independent association was observed between primary language and outcomes after operations typically performed to treat cancer in the study population. The higher proportion of weekend admissions may suggest more acute or advanced presentations for non-English speakers. Long-term ou... 6/13/2019
Mohammad Y Zaidi, Cecilia G Ethun, Yuan Liu, George Poultsides, J Harrison Howard, Harveshp Mogal, Jennifer Tseng, Konstantinos Votanopoulos, Ryan C Fields, Kenneth Cardona The impact of unplanned excisions of truncal/extremity soft tissue sarcomas: A multi-institutional propensity score analysis from the US Sarcoma Collaborative CONCLUSIONS: UE of STS is not associated with worse prognosis compared to PE, though UE is associated with earlier locoregional recurrence in patients with high-grade tumors. Multimodality therapy is needed to achieve improved outcomes in these patients. 6/8/2019
Nicholas P Gannon, David M King, Cecilia G Ethun, John Charlson, Thuy B Tran, George Poultsides, Valerie Grignol, J Harrison Howard, Jennifer Tseng, Kevin K Roggin, Konstantinos Votanopoulos, Bradley Krasnick, Ryan C Fields, Kenneth Cardona, Meena Bedi The role of radiation therapy and margin width in localized soft-tissue sarcoma: Analysis from the US Sarcoma Collaborative CONCLUSIONS: RT may play a larger role in minimizing LR than margin status. In patients with positive margins, RT may decrease LR to similar rates as a negative margin without RT and may be considered to decrease the risk of LR with anticipated close/positive margins. 6/8/2019
Bhavana V Chapman, Cameron W Swanick, Matthew S Ning, Pamela K Allen, Pamela T Soliman, Shannon N Westin, Vishakha Pardeshi, Russell R Broaddus, Karen H Lu, Anuja Jhingran, Patricia J Eifel, Ann H Klopp Adjuvant combined-modality therapy for stage IIIC endometrioid and non-endometrioid endometrial cancer CONCLUSIONS: Combined-modality therapy including adjuvant external beam pelvic radiotherapy yields excellent outcomes for patients with all subtypes of node-positive endometrial cancer. The most pronounced DSS advantage from adjuvant chemoradiotherapy was evident in women with non-endometrioid endom... 5/22/2019
Matthew R Egyud, Jennifer F Tseng, Kei Suzuki Multidisciplinary Therapy of Esophageal Cancer Multimodality therapy is the standard of care for locoregional esophageal cancers (greater than clinical T3 or Nþ), including Siewert type 1 and 2 gastroesophageal junction tumors. Induction regimen, chemotherapy only or chemoradiation, is an area of controversy and often institution-specific, as n... 5/4/2019
Yoav Vardi, Itzhak Levy, Liat Ashkenazi-Hoffnung, Gilad Sherman, Itay Berger, Eran Rom, Gabriel Chodick, Daniel Landau, Oded Scheuerman Pediatric Infectious Sacroiliitis: Characterization and Differentiation from Noninfectious Etiologies CONCLUSIONS: An acute unilateral presentation in young patients ≤2 years of age, without chronic medical conditions, suggests an infectious etiology of SI anticipated to completely resolve with antibiotic treatment, not necessitating further workup for noninfectious etiologies. 4/16/2019
Daniel Halperin, Vadim Dolgin, Michael Geylis, Max Drabkin, Yuval Yogev, Ohad Wormser, Ruth Schreiber, Hanna Shalev, Daniel Landau, Ohad S Birk A novel SLC12A1 mutation in Bedouin kindred with antenatal Bartter syndrome type I Four affected individuals of consanguineous kindred presented at infancy with an apparently autosomal recessive syndrome of polyuria and hypokalemic metabolic alkalosis, following maternal polyhydramnios and premature delivery, culminating in severe failure to thrive. Hypercalciuria, nephrocalcinosi... 4/13/2019
Sjors Klompmaker, Walderik J van der Vliet, Stijn J Thoolen, Ana Sofia Ore, Koen Verkoulen, Monica Solis-Velasco, Elena G Canacari, Jonathan B Kruskal, Khalid O Khwaja, Jennifer F Tseng, Mark P Callery, Tara S Kent, A James Moser Procedure-specific Training for Robot-assisted Distal Pancreatectomy CONCLUSION: Supervised procedure-specific training enabled successful implementation of RADP by practicing surgeons with immediate improvements in length of stay, without adverse effects on safety. 4/5/2019
Meghan Sri Karuturi, Xiudong Lei, Yu Shen, Sharon H Giordano, Cameron W Swanick, Benjamin D Smith Long-term decision regret surrounding systemic therapy in older breast cancer survivors: A population-based survey study INTRODUCTION: Little is known regarding regret experienced by older breast cancer survivors surrounding the choice for adjuvant systemic therapy, which limits providers' ability to optimally engage in the shared decision-making process. To address this, we evaluated endocrine therapy and chemotherap... 4/4/2019
Justin Hoffman, Jayeta Chakrabarti, Anna Plotka, Adriana Milillo Naraine, David Kanamori, Rebecca Moroose, Linh Nguyen, Diane Wang, Zev A Wainberg Talazoparib has no clinically relevant effect on QTc interval in patients with advanced solid tumors The aims of this study were (i) to evaluate the effect of talazoparib (1 mg once daily) on cardiac repolarization in patients with advanced solid tumors by assessing corrected QT interval (QTc) and (ii) to examine the relationship between plasma talazoparib concentration and QTc. In this open-label ... 3/16/2019
Aditya Bardia, Ingrid A Mayer, Linda T Vahdat, Sara M Tolaney, Steven J Isakoff, Jennifer R Diamond, Joyce O'Shaughnessy, Rebecca L Moroose, Alessandro D Santin, Vandana G Abramson, Nikita C Shah, Hope S Rugo, David M Goldenberg, Ala M Sweidan, Robert Iannone, Sarah Washkowitz, Robert M Sharkey, William A Wegener, Kevin Kalinsky Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer CONCLUSIONS: Sacituzumab govitecan-hziy was associated with durable objective responses in patients with heavily pretreated metastatic triple-negative breast cancer. Myelotoxic effects were the main adverse reactions. (Funded by Immunomedics; IMMU-132-01 ClinicalTrials.gov number, NCT01631552.). 2/21/2019
Nosayaba Osazuwa-Peters, Kara M Christopher, Lauren M Cass, Sean T Massa, Adnan S Hussaini, Anit Behera, Ronald J Walker, Mark A Varvares What's Love Got to do with it? Marital status and survival of head and neck cancer CONCLUSIONS: Being married confers survival advantage for HNC survivors. Our finding underscores the need to recognise this aspect of survivorship. Social support should be considered part of standard care for managing HNC. There may also be need to develop other support mechanisms, especially for u... 2/21/2019
Daniel Castillo, Juan Manuel Galvez, Luis J Herrera, Fernando Rojas, Olga Valenzuela, Octavio Caba, Jose Prados, Ignacio Rojas Leukemia multiclass assessment and classification from Microarray and RNA-seq technologies integration at gene expression level In more recent years, a significant increase in the number of available biological experiments has taken place due to the widespread use of massive sequencing data. Furthermore, the continuous developments in the machine learning and in the high performance computing areas, are allowing a faster and... 2/13/2019
Daniel Landau, Yael Segev Role of IGF-I in Type 2 diabetes: a focus on the mouse model Insulin resistance, the key mechanism in Type 2 diabetes mellitus (T2DM) is also associated with the deregulation of other glucose homeostasis pathways, such as the growth hormone (GH)-IGF-I system. In this review, we summarize the endocrine and renal GH-IGF axis changes in db/db mice, a model of T2... 2/13/2019
Pragati G Advani, Xiudong Lei, Cameron W Swanick, Ying Xu, Yu Shen, Nathan A Goodwin, Grace L Smith, Sharon H Giordano, Kelly K Hunt, Reshma Jagsi, Benjamin D Smith Local Therapy Decisional Regret in Older Women With Breast Cancer: A Population-Based Study CONCLUSIONS: Local therapy regret afflicts nearly one quarter of our cohort of older breast cancer survivors, and it is associated with black race, less education, and more extensive nodal dissection, but not breast surgery. Regret is distinct from health utility, suggesting that it is a unique psyc... 2/5/2019
Nosayaba Osazuwa-Peters, Eric Adjei Boakye, Rebecca L Rohde, Rajan N Ganesh, Ammar S Moiyadi, Adnan S Hussaini, Mark A Varvares Understanding of risk factors for the human papillomavirus (HPV) infection based on gender and race This study assessed if race and gender predict known sexual risk factors associated with HPV. Data (n = 301) were from a cross-sectional study conducted at a drag racing event on September 12-13, 2015 in Madison, Illinois. Both multivariable logistic and linear regression models estimated the associ... 1/24/2019
Ammara A Watkins, Manuel Castillo-Angeles, Rodrigo Calvillo-Ortiz, Camila R Guetter, Mariam F Eskander, Eiman Ghaffarpasand, Luis Anguiano-Landa, Jennifer F Tseng, Arthur J Moser, Mark P Callery, Tara S Kent Braden scale for pressure ulcer risk predicts rehabilitation placement after pancreatic resection CONCLUSION: A marker of frailty routinely collected daily by nursing staff, the Braden scale, is available to help surgeons predict the need for postoperative rehabilitation placement after pancreatic resection. Engaging discharge planning services for at-risk patients may help prevent delayed hospi... 1/5/2019
María M Pérez, Luis Javier Herrera, Francisco Carrillo, Oscar E Pecho, Diana Dudea, Cristina Gasparik, Razvan Ghinea, Alvaro Della Bona Whiteness difference thresholds in dentistry OBJECTIVE: To determine the visual whiteness thresholds for esthetic dentistry using the whiteness index for dentistry based on CIELAB color space (WI(D)). 12/12/2018
Katheryn Hope Wilkinson, Cecilia G Ethun, Matthew Hembrook, Meena Bedi, John Charlson, Harveshp Mogal, Susan Tsai, Kathleen Christians, Thuy B Tran, George Poultsides, Valerie Grignol, John Harrison Howard, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Darren Cullinan, Ryan C Fields, Sharon Weber, Thomas Clark Gamblin, Kenneth Cardona, Callisia N Clarke Outcomes of Elderly Patients Undergoing Curative Resection for Retroperitoneal Sarcomas: Analysis From the US Sarcoma Collaborative CONCLUSIONS: Advanced age was not associated with an increased risk of perioperative morbidity and mortality following resection of RPS in this multi-institutional review. Although short-term oncologic outcomes were similar in both groups, the risk of death after sarcoma recurrence was higher in eld... 12/4/2018
Munizay Paracha, Kathryn Van Orden, Gregory Patts, Jennifer Tseng, David McAneny, Teviah Sachs Opportunity Lost? Diagnostic Laparoscopy in Patients with Pancreatic Cancer in the National Surgical Quality Improvement Program Database BACKGROUND: Routine preoperative staging in pancreas cancer is controversial. We sought to evaluate the rates of diagnostic laparoscopy (DLAP) for pancreatic cancer. 11/28/2018
Neige Journy, Daniel J Indelicato, Diana R Withrow, Tetsuo Akimoto, Claire Alapetite, Masayuki Araya, Andrew Chang, John Han-Chih Chang, Brian Chon, Michael E Confer, Yusuke Demizu, Rémi Dendale, Jérôme Doyen, Ralph Ermoian, Kristin Gurtner, Christine Hill-Kayser, Hiromitsu Iwata, Joo-Young Kim, Young Kwok, Nadia N Laack, Choonsik Lee, Do Hoon Lim, Lilia Loredo, Victor S Mangona, David B Mansur, Masao Murakami, Shigeyuki Murayama, Takashi Ogino, Barbora Ondrová, Rahul R Parikh, Arnold C Paulino, Stephanie Perkins, Naren R Ramakrishna, Ronald Richter, Barbara Rombi, Satoshi Shibata, Shinichi Shimizu, Beate Timmermann, Tamara Vern-Gross, Chiachien J Wang, Damien C Weber, John Ben Wilkinson, Petra Witt Nyström, Torunn I Yock, Ruth A Kleinerman, Amy Berrington de Gonzalez Patterns of proton therapy use in pediatric cancer management in 2016: An international survey CONCLUSION: To our knowledge, this survey provides the first worldwide assessment of proton therapy use for pediatric cancer management. Since previous estimates in the United States and Europe, CNS tumors remain the cancer types most commonly treated with protons in 2016. However, the proportion of... 11/12/2018
Debra L Richardson, Shelly M Seward, Kathleen N Moore Antibody Drug Conjugates in the Treatment of Epithelial Ovarian Cancer Antibody drug conjugates are novel mechanisms for delivering chemotherapy. They vary based on the targeted antigen, conjugated cytotoxic, and the type of linker used. These differences determine what cells are targeted. There are 2 antibody drug conjugates approved for use in cancer. For epithelial ... 11/5/2018
Simona F Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S Bloom, Isidora Y Arzu, Daniel Buchholz, Gregory Chronowski, Tomas Dvorak, Emily Grade, Karen Hoffman, George Perkins, Valerie K Reed, Shalin J Shah, Michael C Stauder, Eric A Strom, Welela Tereffe, Wendy A Woodward, Diana N Amaya, Yu Shen, Gabriel N Hortobagyi, Kelly K Hunt, Thomas A Buchholz, Benjamin D Smith Three-Year Outcomes With Hypofractionated Versus Conventionally Fractionated Whole-Breast Irradiation: Results of a Randomized, Noninferiority Clinical Trial CONCLUSION: Three years after WBI followed by a tumor bed boost, outcomes with hypofractionation and conventional fractionation are similar. Tumor bed boost, chemotherapy, and larger breast size do not seem to be strong contraindications to HF-WBI. 11/1/2018
Stijn van Roessel, Gyulnara G Kasumova, Joanne Verheij, Robert M Najarian, Laura Maggino, Matteo de Pastena, Giuseppe Malleo, Giovanni Marchegiani, Roberto Salvia, Sing Chau Ng, Susanna W de Geus, Sanne Lof, Francesco Giovinazzo, Jacob L van Dam, Tara S Kent, Olivier R Busch, Casper H van Eijck, Bas Groot Koerkamp, Mohammed Abu Hilal, Claudio Bassi, Jennifer F Tseng, Marc G Besselink International Validation of the Eighth Edition of the American Joint Committee on Cancer (AJCC) TNM Staging System in Patients With Resected Pancreatic Cancer CONCLUSIONS AND RELEVANCE: The eighth edition of the TNM staging system demonstrated a more equal distribution among stages and a modestly increased prognostic accuracy in patients with resected pancreatic ductal adenocarcinoma compared with the seventh edition. The revised T stage remains poorly as... 10/5/2018
Peter Y Yu, Eliza W Beal, Tasha M Hughes, Lorena P Suarez-Kelly, Rita D Shelby, Cecilia G Ethun, Thuy B Tran, George Poultsides, John Charlson, T Clark Gamblin, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley A Krasnick, Ryan C Fields, Raphael E Pollock, Valerie Grignol, Kenneth Cardona, J Harrison Howard Perioperative chemotherapy is not associated with improved survival in high-grade truncal sarcoma CONCLUSIONS: In this multi-institutional retrospective analysis of resected high-grade truncal STS, receipt of perioperative CTX was not associated with improved OS, which may be related to selection bias. Microscopically negative margin status was the only independent factor associated with OS. 10/4/2018
Aileen C Johnson, Cecilia G Ethun, Yuan Liu, George Poultsides, John H Howard, Meena Bedi, John Charlson, Jennifer Tseng, Kevin K Roggin, Konstantinos Votanopoulos, Darren Cullinan, Ryan C Fields, Shishir K Maithel, Kenneth Cardona, and other members of the US Sarcoma Collaborative A novel, simplified, externally validated staging system for truncal/extremity soft tissue sarcomas: An analysis of the US Sarcoma Collaborative database CONCLUSIONS: Our proposed staging system maintains prognostic significance between stages within a simplified system. For high-grade tumors, a cutoff of 7.5 cm, instead of 5 cm, maintains discrimination for survival and could be a more clinically applicable cutoff for future clinical trials. 9/28/2018
Rafael Mañon, Veronica Schimp, Priya Gopalan, Kavita Pattani, Jennifer Tseng The Impact of HPV as an Etiological Factor in Gynecological and Oropharyngeal Cancer The human papilloma virus (HPV) is one of several viral pathogens linked to human cancer. This article reviews the current worldwide cancer burden related to this pathogen. The article also examines the role of HPV in oropharyngeal and gynecological malignancies, current treatment implications, and ... 9/12/2018
Krista Hachey, Ryan Morgan, Amy Rosen, Sowmya R Rao, David McAneny, Jennifer Tseng, Gerard Doherty, Teviah Sachs Quality Comes with the (Anatomic) Territory: Evaluating the Impact of Surgeon Operative Mix on Patient Outcomes After Pancreaticoduodenectomy CONCLUSIONS: Surgeon PD volume is an important predictor of outcomes after PD. However, surgeon OM volume identifies a subset of lower-PD-volume surgeons with more favorable outcomes. 9/7/2018
Evgenia Gurevich, Eytan Israel, Yael Segev, Daniel Landau Febrile Proteinuria in Hospitalized Children: Characterization of Urinary Proteins Background: Transient proteinuria during febrile illness is a common phenomenon. Recent studies have re-examined the pathophysiology of proteinuria and new urinary markers to characterize it, including B7-1 (CD80), which is expressed also in glomerular podocytes and influences the glomerular barrier... 9/4/2018
Jeffrey J Siracuse, Munizay Paracha, Alik Farber, Denis Rybin, Gheorghe Doros, Jennifer Tseng, David McAneny, Teviah Sachs Never events after hepatopancreatobiliary operations BACKGROUND: In 2008, the Centers for Medicare & Medicaid Services (CMS) terminated reimbursement for never events (NE). NE in hepatopancreatobiliary (HPB) patients are poorly understood. We investigated the incidence and effects of NE in this population. 8/28/2018
Gal Finer, Daniel Landau Clinical Approach to Proximal Renal Tubular Acidosis in Children Proximal renal tubular acidosis (pRTA) is an inherited or acquired clinical syndrome in which there is a decreased bicarbonate reclamation in the proximal tubule resulting in normal anion gap hyperchloremic metabolic acidosis. In children, pRTA may be isolated but is often associated with a general ... 8/25/2018
Shane R Stecklein, Simona F Shaitelman, Gildy V Babiera, Isabelle Bedrosian, Dalliah M Black, Matthew T Ballo, Isadora Arzu, Eric A Strom, Valerie K Reed, Tomas Dvorak, Benjamin D Smith, Wendy A Woodward, Karen E Hoffman, Pamela J Schlembach, Steve M Kirsner, Christopher L Nelson, Jinzhong Yang, William Guerra, Shiva Dibaj, Elizabeth S Bloom Prospective Comparison of Toxicity and Cosmetic Outcome After Accelerated Partial Breast Irradiation With Conformal External Beam Radiotherapy or Single-Entry Multilumen Intracavitary Brachytherapy CONCLUSIONS: Brachytherapy APBI is associated with higher rates of grade 1 fibrosis and seroma than 3-dimensional CRT but lower rates of grade 1 edema and grade 2 to 3 pain than 3-dimensional CRT. Rates of radiation oncologist-reported fair or poor cosmetic outcomes are higher with brachytherapy. We... 8/21/2018
Ryan Morgan, Michael Cassidy, Susanna W L DeGeus, Jennifer Tseng, David McAneny, Teviah Sachs Presentation and Survival of Gastric Cancer Patients at an Urban Academic Safety-Net Hospital CONCLUSION: Hispanic ethnicity, Central American birthplace, Medicaid insurance, and increased neighborhood poverty were associated with late-stage presentation of gastric cancer with poor outcomes. Further study of these populations may lead to screening protocols in order to increase earlier detec... 8/12/2018
Munizay Paracha, Ariel E Hirsch, Jennifer F Tseng, David B McAneny, Teviah E Sachs Scholarly impact of student authorship on surgical research CONCLUSIONS: The number of SA in JACS publications is increasing, without detriment to CA scholarly advancement. Involving students in surgical research should be encouraged. 8/9/2018
Naren Ramakrishna, Sarah Temin, Sarat Chandarlapaty, Jennie R Crews, Nancy E Davidson, Francisco J Esteva, Sharon H Giordano, Jeffrey J Kirshner, Ian E Krop, Jennifer Levinson, Shanu Modi, Debra A Patt, Jane Perlmutter, Eric P Winer, Nancy U Lin Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases: ASCO Clinical Practice Guideline Update Purpose To update the formal expert consensus-based guideline recommendations for practicing oncologists and others on the management of brain metastases for patients with human epidermal growth factor receptor 2-positive advanced breast cancer to 2018. Methods An Expert Panel conducted a targeted s... 6/26/2018
Sharon H Giordano, Sarah Temin, Sarat Chandarlapaty, Jennie R Crews, Francisco J Esteva, Jeffrey J Kirshner, Ian E Krop, Jennifer Levinson, Nancy U Lin, Shanu Modi, Debra A Patt, Jane Perlmutter, Naren Ramakrishna, Eric P Winer, Nancy E Davidson Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: ASCO Clinical Practice Guideline Update Purpose To update evidence-based guideline recommendations for practicing oncologists and others on systemic therapy for patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer to 2018. Methods An Expert Panel conducted a targeted systematic literature review (f... 6/26/2018
Renata Ferrarotto, William N William, Jennifer E Tseng, Shanthi Marur, Dong M Shin, Barbara Murphy, Ezra E W Cohen, Christopher Y Thomas, Richard Willey, Jan Cosaert, Nusrat Harun, J Jack Lee, Ignacio W Wistuba, Robert I Haddad, Bonnie S Glisson Randomized phase II trial of cixutumumab alone or with cetuximab for refractory recurrent/metastatic head and neck squamous cell carcinoma CONCLUSION: The results of this study do not support the use of cixutumumab alone or with cetuximab in unselected patients with R/M HNSCC. 6/19/2018
Aileen C Johnson, Cecilia G Ethun, Yuan Liu, Alexandra G Lopez-Aguiar, Thuy B Tran, George Poultsides, Valerie Grignol, J Harrison Howard, Meena Bedi, T Clark Gamblin, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Darren Cullinan, Ryan C Fields, Keith A Delman, William C Wood, Kenneth Cardona, Shishir K Maithel Studying a Rare Disease Using Multi-Institutional Research Collaborations vs Big Data: Where Lies the Truth? CONCLUSIONS: Granular data afforded by collaborative research enables in-depth analysis of patient outcomes. The NCDB, although powered with large numbers, cannot assess many relevant outcomes (eg recurrence, DSS, or complications). In this study, the approaches yielded conflicting results. The USSC... 6/16/2018
Marianne Salas, Cristina Lucena, Luis Javier Herrera, Ana Yebra, Alvaro Della Bona, María M Pérez Translucency thresholds for dental materials OBJECTIVE: To determine the translucency acceptability and perceptibility thresholds for dental resin composites using CIEDE2000 and CIELAB color difference formulas. 5/17/2018
Juan Manuel Gálvez, Daniel Castillo, Luis Javier Herrera, Belén San Román, Olga Valenzuela, Francisco Manuel Ortuño, Ignacio Rojas Multiclass classification for skin cancer profiling based on the integration of heterogeneous gene expression series Most of the research studies developed applying microarray technology to the characterization of different pathological states of any disease may fail in reaching statistically significant results. This is largely due to the small repertoire of analysed samples, and to the limitation in the number o... 5/12/2018
Daniel Landau, Lital London, Inbar Bandach, Yael Segev The hypoxia inducible factor/erythropoietin (EPO)/EPO receptor pathway is disturbed in a rat model of chronic kidney disease related anemia CONCLUSIONS: Compared to blood loss, anemia in young CKD rats is associated with inappropriate responses in the HIF-EPO-EPO-R axis: kidney HIF2α and renal EPO are not increased, BM and bone EPOR levels, as well as bone pSTAT5 response to EPO are reduced. Thus, anemia of CKD may be treated with addi... 5/9/2018
Razvan Ghinea, Luis Javier Herrera, María M Pérez, Ana M Ionescu, Rade D Paravina Gingival shade guides: Colorimetric and spectral modeling CONCLUSIONS: An increase in the number of clusters in the gingival shade guide models was associated with a decrease in coverage error (better match) to human gingiva. Gingival shade guide models with only 4 tabs provided a CIELAB and CIEDE2000 coverage error lower than the acceptability threshold f... 4/19/2018
Stijn van Roessel, Gyulnara G Kasumova, Omidreza Tabatabaie, Sing Chau Ng, L Bengt van Rijssen, Joanne Verheij, Robert M Najarian, Thomas M van Gulik, Marc G Besselink, Olivier R Busch, Jennifer F Tseng Pathological Margin Clearance and Survival After Pancreaticoduodenectomy in a US and European Pancreatic Center CONCLUSIONS: In patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma, a margin clearance of ≥1 mm correlates with improved survival relative to < 1 mm clearance and may be a more accurate predictor of a complete margin-negative resection in pancreatic cancer. The type of margi... 4/14/2018
Ayòtúndé B Fadayomi, Gyulnara G Kasumova, Omidreza Tabatabaie, Susanna W L de Geus, Tara S Kent, Sing Chau Ng, A James Moser, Mark P Callery, Stanley W Ashley, Jennifer F Tseng Unique predictors and economic burden of superficial and deep/organ space surgical site infections following pancreatectomy CONCLUSION: Deep/organ space SSI contributes more profoundly to prolonged hospital stay, readmission, and additional costs, suggesting that strategies should focus on preferential prevention of deep/organ space infections. 3/13/2018
Yuk Pheel Park, Linchun Jin, Katie B Bennett, Dunrui Wang, Kristianna M Fredenburg, Jennifer E Tseng, Lung-Ji Chang, Jianping Huang, Edward K L Chan CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma CONCLUSION: CD70-specific CAR-T cells specifically recognized and efficiently eliminated CD70-positive HNSCC cells. This study provides the basis for further investigation into CD70 and other CAR-T targets. 3/3/2018
Cameron W Swanick, Xiudong Lei, Ying Xu, Yu Shen, Nathan A Goodwin, Grace L Smith, Sharon H Giordano, Kelly K Hunt, Reshma Jagsi, Simona F Shaitelman, Susan K Peterson, Benjamin D Smith Long-term Patient-Reported Outcomes in Older Breast Cancer Survivors: A Population-Based Survey Study CONCLUSIONS: In this nationally diverse cohort, less irradiation and less surgery were associated with better long-term quality-of-life outcomes. However, patient regret regarding surgery and radiation therapy was similar across all groups. 2/28/2018
María M Pérez, Razvan Ghinea, Luis Javier Herrera, F Carrillo, Ana M Ionescu, Rade D Paravina Color difference thresholds for computer-simulated human Gingiva CONCLUSIONS: The difference between the perceptibility and acceptability threshold for gingiva was statistically significant in both CIEDE2000 and CIELAB. The same was true for differences between the corresponding thresholds using two color difference formulas, and between dentists and laypersons. ... 2/25/2018
Susanna W L de Geus, Gyulnara G Kasumova, Teviah E Sachs, Sing Chau Ng, Tara S Kent, A James Moser, Alexander L Vahrmeijer, Mark P Callery, Jennifer F Tseng Neoadjuvant therapy affects margins and margins affect all: perioperative and survival outcomes in resected pancreatic adenocarcinoma BACKGROUND: Resection margin status is an important prognostic factor in pancreatic cancer; however, the impact of positive resection margins in those who received neoadjuvant therapy remains unclear. The current study investigates the prognostic impact of resection margin status after neoadjuvant t... 2/11/2018
Harold Watson, Ariel Perez, Kwabena Ayesu, Faisal Musa, Jose Sarriera, Mario Madruga, Steve J Carlan Inherited factor II deficiency with paradoxical hypercoagulability: a case report : Congenital deficiency of factor II is a very rare autosomal recessive disorder that can result in a bleeding diathesis. Genotypically, individuals are either homozygous for a defective prothrombin gene or a compound heterozygote with different mutated prothrombin genes inherited from each parent. ... 2/2/2018
Mario Matiotti-Neto, Mariam F Eskander, Omidreza Tabatabaie, Gyulnara Kasumova, Lindsay A Bliss, Sing Chau Ng, Nicholas E Tawa, Blanche Murphy, Jonathan F Critchlow, Jennifer F Tseng Percutaneous <em>versus</em> Cut-Down Technique for Indwelling Port Placement The superiority of surgical cut-down of the cephalic vein versus percutaneous catheterization of the subclavian vein for the insertion of totally implantable venous access devices (TIVADs) is debated. To compare the safety and efficacy of surgical cut-down versus percutaneous placement of TIVADs. Th... 1/17/2018
Sanford L Meeks, Jason Pukala, Naren Ramakrishna, Twyla R Willoughby, Francis J Bova Radiosurgery technology development and use Radiosurgery first became a clinical option in the 1960's because of the Gamma Knife, and the technology proliferated in the 1980's due to the availability of linear accelerator radiosurgery. The technology has continued to develop with both Gamma Knife and linac radiosurgery due primarily to advanc... 1/4/2018
Susanna W L de Geus, Gyulnara G Kasumova, Mariam F Eskander, Sing Chau Ng, Tara S Kent, A James Moser, Alexander L Vahrmeijer, Mark P Callery, Jennifer F Tseng Is Neoadjuvant Therapy Sufficient in Resected Pancreatic Cancer Patients? A National Study CONCLUSIONS: Our results using national data suggest that after receipt of neoadjuvant therapy and pancreatectomy, additional postoperative therapy may not provide additional survival benefit. These data warrant further prospective data collection and consideration for clinical trials. 12/14/2017
Nufar Marcus, Keren Smuel, Moran Almog, Dario Prais, Rachel Straussberg, Daniel Landau, Oded Scheuerman Successful Intravenous Immunoglobulin Treatment in Pediatric Severe DRESS Syndrome CONCLUSION: The addition of IVIG in DRESS syndrome resistant to regular drug withdrawal and systemic corticosteroid therapy may hasten disease recovery. 12/5/2017
Daniel Castillo, Juan Manuel Gálvez, Luis Javier Herrera, Belén San Román, Fernando Rojas, Ignacio Rojas Integration of RNA-Seq data with heterogeneous microarray data for breast cancer profiling CONCLUSIONS: This work proposes a novel data integration stage in the traditional gene expression analysis pipeline through the combination of heterogeneous data from microarrays and RNA-Seq technologies. Available samples have been successfully classified using a subset of six genes obtained by a f... 11/22/2017
Zhi Rong Qian, Douglas A Rubinson, Jonathan A Nowak, Vicente Morales-Oyarvide, Richard F Dunne, Margaret M Kozak, Marisa W Welch, Lauren K Brais, Annacarolina Da Silva, Tingting Li, Wanwan Li, Atsuhiro Masuda, Juhong Yang, Yan Shi, Mancang Gu, Yohei Masugi, Justin Bui, Caitlin L Zellers, Chen Yuan, Ana Babic, Natalia Khalaf, Andrew Aguirre, Kimmie Ng, Rebecca A Miksad, Andrea J Bullock, Daniel T Chang, Jennifer F Tseng, Thomas E Clancy, David C Linehan, Jennifer J Findeis-Hosey, Leona A Doyle, Aaron R Thorner, Matthew Ducar, Bruce Wollison, Angelica Laing, William C Hahn, Matthew Meyerson, Charles S Fuchs, Shuji Ogino, Jason L Hornick, Aram F Hezel, Albert C Koong, Brian M Wolpin Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma CONCLUSIONS AND RELEVANCE: Patient outcomes are associated with alterations of the 4 main driver genes in resected pancreatic adenocarcinoma. 11/4/2017
Todd A Pezzi, Chad Tang, Cameron W Swanick, Penny Fang, Kenneth Hess, Ting Xu, Stephen M Hahn, Joe Y Chang, Zhongxing Liao, Daniel Gomez Patterns and correlates of treatment failure in relation to isodose distribution in non-small cell lung cancer: An analysis of 1522 patients in the modern era CONCLUSION: In this large study of patients treated in the modern era with varying dose fractionation regimens, higher BED was associated with improved freedom from in-field failure, and that this relationship appeared to be consistent with the classically described sigmoid shape. We also found that... 10/22/2017
Vicente Morales-Oyarvide, Douglas A Rubinson, Richard F Dunne, Margaret M Kozak, Justin L Bui, Chen Yuan, Zhi Rong Qian, Ana Babic, Annacarolina Da Silva, Jonathan A Nowak, Natalia Khalaf, Lauren K Brais, Marisa W Welch, Caitlin L Zellers, Kimmie Ng, Daniel T Chang, Rebecca A Miksad, Andrea J Bullock, Jennifer F Tseng, Richard S Swanson, Thomas E Clancy, David C Linehan, Jennifer J Findeis-Hosey, Leona A Doyle, Jason L Hornick, Shuji Ogino, Charles S Fuchs, Aram F Hezel, Albert C Koong, Brian M Wolpin Lymph node metastases in resected pancreatic ductal adenocarcinoma: predictors of disease recurrence and survival CONCLUSIONS: American Joint Committee on Cancer 8th edition LN classification is an effective and practical tool to predict outcomes in patients with resected PDAC. However, the prognostic value of LN metastases is attenuated in patients with positive resection margins and distal pancreatectomies. 10/6/2017
Jennifer Tseng, Mitchell C Posner An Update on Randomized Clinical Trials in Gastric Cancer The optimal treatment of esophageal cancer is still being defined. The timing of surgical management and the application of chemotherapy and radiation in the neoadjuvant and adjuvant settings have been studied in several prospective, randomized, controlled trials. This article outlines some of the h... 9/20/2017
Maarten R Struyvenberg, Zhi Ven Fong, Camilia R Martin, Jennifer F Tseng, Thomas E Clancy, Carlos Fernández-Del Castillo, Hanna J Tillman, Melena D Bellin, Steven D Freedman Impact of Treatments on Diabetic Control and Gastrointestinal Symptoms After Total Pancreatectomy CONCLUSIONS: After TP, CSII therapy is safe compared with MDIs in T3cDM and not associated with an increase in severe hypoglycemic events. Pancreatic enzyme replacement therapy is highly variable with low doses associated with unintentional weight loss and gastrointestinal symptoms. 9/14/2017
Jay-Jiguang Zhu, Petya Demireva, Andrew A Kanner, Susan Pannullo, Maximilian Mehdorn, Nicholas Avgeropoulos, Andrea Salmaggi, Antonio Silvani, Samuel Goldlust, Carlos David, Alexandra Benouaich-Amiel, Zvi Ram on behalf of the EF-14 Trial Investigators Health-related quality of life, cognitive screening, and functional status in a randomized phase III trial (EF-14) of tumor treating fields with temozolomide compared to temozolomide alone in newly diagnosed glioblastoma We characterized health-related quality of life (HRQoL), cognitive, and functional status in newly diagnosed glioblastoma (GBM) patients receiving Tumor treating fields (TTFields) with temozolomide (TMZ) versus TMZ alone in a planned interim analysis of a randomized phase III trial [NCT00916409], wh... 8/30/2017
Lainie P Martin, Jason A Konner, Kathleen N Moore, Shelly M Seward, Ursula A Matulonis, Raymond P Perez, Ying Su, Anna Berkenblit, Rodrigo Ruiz-Soto, Michael J Birrer Characterization of folate receptor alpha (FRα) expression in archival tumor and biopsy samples from relapsed epithelial ovarian cancer patients: A phase I expansion study of the FRα-targeting antibody-drug conjugate mirvetuximab soravtansine CONCLUSION: Concordance of FRα expression in biopsy versus archival tumor samples suggests that archival tissue can reliably identify patients with receptor-positive tumors and is appropriate for patient selection in mirvetuximab soravtansine clinical trials. Regardless of the tissue source analyze... 8/28/2017
Susanna W L de Geus, Mariam F Eskander, Gyulnara G Kasumova, Sing Chau Ng, Tara S Kent, Joseph D Mancias, Mark P Callery, Anand Mahadevan, Jennifer F Tseng Stereotactic body radiotherapy for unresected pancreatic cancer: A nationwide review CONCLUSIONS: SBRT is associated with a significantly better outcome than chemotherapy alone or in conjunction with traditional EBRT. These results support the idea that SBRT is a promising treatment approach for patients with unresected pancreatic cancer. Cancer 2017;123:4158-4167. © 2017 American ... 7/15/2017
Gyulnara G Kasumova, Omidreza Tabatabaie, Robert M Najarian, Mark P Callery, Sing Chau Ng, Andrea J Bullock, Robert A Fisher, Jennifer F Tseng Surgical Management of Gallbladder Cancer: Simple Versus Extended Cholecystectomy and the Role of Adjuvant Therapy CONCLUSIONS: Adjuvant therapy prolongs survival after resection of T2/T3 tumors. Simple cholecystectomy with adjuvant therapy appears to be superior to extended resection alone in the short term and may serve as a potential alternative to re-resection in select high-risk individuals. 7/11/2017
Ismail Mert, Jasdeep Chhina, Ghassan Allo, Jing Dai, Shelly Seward, Mark S Carey, Marta Llaurado, Shailendra Giri, Ramandeep Rattan, Adnan R Munkarah Synergistic effect of MEK inhibitor and metformin combination in low grade serous ovarian cancer CONCLUSIONS: Metformin alone or in combination with MEK and glycolytic inhibitors may be a potential therapy for LGSOC, a cancer that is indolent but chemo-resistant. 5/27/2017
Nosayaba Osazuwa-Peters, Eric Adjei Boakye, Adnan S Hussaini, Nanthiya Sujijantarat, Rajan N Ganesh, Matthew Snider, Devin Thompson, Mark A Varvares Characteristics and predictors of oral cancer knowledge in a predominantly African American community CONCLUSIONS: There was lower oral cancer knowledge among African Americans and those with low education. The prevalence of smoking was also very high. Understanding predictors of oral cancer knowledge is important in future design of educational interventions specifically targeted towards high-risk ... 5/26/2017
Omidreza Tabatabaie, Gyulnara G Kasumova, Tara S Kent, Mariam F Eskander, Ayotunde B Fadayomi, Sing Chau Ng, Jonathan F Critchlow, Nicholas E Tawa, Jennifer F Tseng Upper extremity deep venous thrombosis after port insertion: What are the risk factors? CONCLUSION: This study identified major risk factors of upper extremity deep venous thrombosis. Further studies are needed to evaluate the appropriateness of thromboprophylaxis in patients at greater risk of upper extremity deep venous thrombosis. 5/25/2017
Evgenia Gurevich, Daniel Landau SEVERE INFANTILE HYPOPHOSPHATASIA Hypophosphatasia is the inborn error of metabolism that is characterized by low serum alkaline-phosphatase activity, due to loss-of-function mutations within the gene for tissuenonspecific isoenzyme of alkaline phosphatase [TNSALP]. The manifestations of hypophosphatasia range from neonatal death wi... 5/23/2017
Cameron W Swanick, Patricia J Eifel, Jinhai Huo, Larissa A Meyer, Grace L Smith Challenges to delivery and effectiveness of adjuvant radiation therapy in elderly patients with node-positive vulvar cancer CONCLUSIONS: In this cohort of older women with node-positive vulvar cancer, achieving metrics for RT delivery was an important factor for optimizing disease benefits from treatment. 5/17/2017
Gyulnara G Kasumova, Mariam F Eskander, Susanna W L de Geus, Mario Matiotti Neto, Omidreza Tabatabaie, Sing Chau Ng, Rebecca A Miksad, Anand Mahadevan, James R Rodrigue, Jennifer F Tseng Regional variation in the treatment of pancreatic adenocarcinoma: Decreasing disparities with multimodality therapy CONCLUSION: Regional variations exist in pancreatic cancer treatment and survival. While providing multimodality cancer-directed therapy can help mitigate these differences, survival with pancreatic cancer needs to be interpreted in the context of overall health, underlying risk factors, and life ex... 5/11/2017
Kathleen N Moore, Hossein Borghaei, David M O'Malley, Woondong Jeong, Shelly M Seward, Todd M Bauer, Raymond P Perez, Ursula A Matulonis, Kelli L Running, Xiaoyan Zhang, Jose F Ponte, Rodrigo Ruiz-Soto, Michael J Birrer Phase 1 dose-escalation study of mirvetuximab soravtansine (IMGN853), a folate receptor α-targeting antibody-drug conjugate, in patients with solid tumors CONCLUSIONS: IMGN853 demonstrated a manageable safety profile and encouraging preliminary clinical activity, particularly in patients with ovarian cancer. The results establish a recommended phase 2 dosing of 6.0 mg/kg (based on adjusted ideal body weight) once every 3 weeks. Cancer 2017. © 2017 Am... 4/26/2017
Penny Fang, Cameron W Swanick, Todd A Pezzi, Zhongxing Liao, James Welsh, Steven H Lin, Daniel R Gomez Outcomes and toxicity following high-dose radiation therapy in 15 fractions for non-small cell lung cancer CONCLUSIONS: AHRT in 15 fractions can be safe and effective. Consideration for using AHRT with immunotherapy and sequential chemotherapy for improved out-of-radiation field and distant control is warranted. 4/22/2017
Jennifer Tseng, Alexandra Kyrillos, Erik Liederbach, Georgia G Spear, Jacob Ecanow, Chi-Hsiung Wang, Tom Czechura, Olga Kantor, Megan Miller, David J Winchester, Catherine E Pesce, Sarah Rabbitt, Katharine Yao Clinical accuracy of preoperative breast MRI for breast cancer CONCLUSIONS: Breast MRI provides greater accuracy for a third of patients undergoing preoperative MGM and U/S. Mammographic calcifications were associated with MRI clinical accuracy for patients with invasive cancer. 4/15/2017
Meir Mizrahi, Jennifer F Tseng, Daniel Wong, Nadine Tung, Mariam F Eskander, Tyler M Berzin, Douglas K Pleskow, Mandeep S Sawhney Chronic Pancreatitis-Like Change in BRCA2 Mutation Carriers CONCLUSIONS: Chronic pancreatitis-like changes, along with solid and cystic pancreatic lesions, were significantly more common in BRCA2 mutation carriers than in noncarriers. 4/5/2017
Susanna W L de Geus, Mariam F Eskander, Lindsay A Bliss, Gyulnara G Kasumova, Sing Chau Ng, Mark P Callery, Jennifer F Tseng Neoadjuvant therapy versus upfront surgery for resected pancreatic adenocarcinoma: A nationwide propensity score matched analysis CONCLUSION: The survival impact of neoadjuvant therapy is stage-dependent. Neoadjuvant therapy does not disadvantage survival compared with conventional upfront surgery followed by adjuvant therapy in any stage, and is associated with a significant survival advantage in stage III pancreatic cancer. 3/26/2017
Yonatan Perez, Zamir Shorer, Keren Liani-Leibson, Pauline Chabosseau, Rotem Kadir, Michael Volodarsky, Daniel Halperin, Shiran Barber-Zucker, Hanna Shalev, Ruth Schreiber, Libe Gradstein, Evgenia Gurevich, Raz Zarivach, Guy A Rutter, Daniel Landau, Ohad S Birk SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome A novel autosomal recessive cerebro-renal syndrome was identified in consanguineous Bedouin kindred: neurological deterioration was evident as of early age, progressing into severe intellectual disability, profound ataxia, camptocormia and oculomotor apraxia. Brain MRI was normal. Four of the six af... 3/24/2017
Aditya Bardia, Ingrid A Mayer, Jennifer R Diamond, Rebecca L Moroose, Steven J Isakoff, Alexander N Starodub, Nikita C Shah, Joyce O'Shaughnessy, Kevin Kalinsky, Michael Guarino, Vandana Abramson, Dejan Juric, Sara M Tolaney, Jordan Berlin, Wells A Messersmith, Allyson J Ocean, William A Wegener, Pius Maliakal, Robert M Sharkey, Serengulam V Govindan, David M Goldenberg, Linda T Vahdat Efficacy and Safety of Anti-Trop-2 Antibody Drug Conjugate Sacituzumab Govitecan (IMMU-132) in Heavily Pretreated Patients With Metastatic Triple-Negative Breast Cancer Purpose Trop-2, expressed in most triple-negative breast cancers (TNBCs), may be a potential target for antibody-drug conjugates. Sacituzumab govitecan, an antibody-drug conjugate, targets Trop-2 for the selective delivery of SN-38, the active metabolite of irinotecan. Patients and Methods We evalua... 3/15/2017
Serena Byrd, Adnan S Hussaini, Jastin Antisdel Acute Vision Loss Following Endoscopic Sinus Surgery A 41-year-old female with a history of uterine cancer and Celiac and Raynaud's Disease presented to our institution with frequent migraines and nasal congestion. She underwent functional endoscopic sinus surgery (FESS) and experienced acute unilateral vision loss postoperatively. Rapid recognition o... 3/14/2017
Mary Masterman, Robert M Cronin, Sharon E Davis, Jared A Shenson, Gretchen P Jackson Adoption of Secure Messaging in a Patient Portal across Pediatric Specialties Few studies have explored adoption of patient portals for pediatric patients outside primary care or disease-specific applications. We examined use of patient-provider messaging in a patient portal across pediatric specialties during the three years after implementation of pediatric portal accounts ... 3/9/2017
Omidreza Tabatabaie, Gyulnara G Kasumova, Mariam F Eskander, Jonathan F Critchlow, Nicholas E Tawa, Jennifer F Tseng Totally Implantable Venous Access Devices: A Review of Complications and Management Strategies CONCLUSIONS: Physicians should be familiar with port complications and their diagnosis and management. 1/21/2017
Olga Kantor, Catherine Pesce, Puneet Singh, Megan Miller, Jennifer Tseng, Chi-Hsiung Wang, David J Winchester, Katharine Yao Post-mastectomy radiation therapy and overall survival after neoadjuvant chemotherapy CONCLUSIONS: PMRT is associated with improved OS in patients with cN1 and cN2 disease after NAC and mastectomy. However, in the subgroup of patients that were ypN0 after NAC, PMRT improved OS for hormone-receptor negative patients but not hormone-receptor positive patients. 1/14/2017
Joanne B Weidhaas, Jonathan Harris, Dörthe Schaue, Allen M Chen, Robert Chin, Rita Axelrod, Adel K El-Naggar, Anurag K Singh, Thomas J Galloway, David Raben, Dian Wang, Chance Matthiesen, Vilija N Avizonis, Rafael R Manon, Omar Yumen, Phuc Felix Nguyen-Tan, Andy Trotti, Heath Skinner, Qiang Zhang, Robert L Ferris, David Sidransky, Christine H Chung The KRAS-Variant and Cetuximab Response in Head and Neck Squamous Cell Cancer: A Secondary Analysis of a Randomized Clinical Trial CONCLUSIONS AND RELEVANCE: Patients with the KRAS-variant with HNSCC significantly benefit from the addition of cetuximab to radiotherapy and cisplatin, and there is a significant interaction between the KRAS-variant and p16 status. Elevated TGF-β1 levels in patients with the KRAS-variant suggests ... 12/23/2016
Gyulnara G Kasumova, Omidreza Tabatabaie, Mariam F Eskander, Abhishek Tadikonda, Sing Chau Ng, Jennifer F Tseng National Rise of Primary Pancreatic Carcinoid Tumors: Comparison to Functional and Nonfunctional Pancreatic Neuroendocrine Tumors CONCLUSIONS: Primary pancreatic carcinoid tumors are increasingly being diagnosed. Differentiating PNET subtypes plays an important role in prognostication. Resection remains a critical component of care. 12/15/2016
Gyulnara G Kasumova, W Charles Conway, Jennifer F Tseng The Role of Venous and Arterial Resection in Pancreatic Cancer Surgery Pancreatic cancer continues to carry a dismal prognosis with the majority of patients presenting at advanced stages of disease. Complete surgical resection remains essential for prolonging survival and increasing the possibility of cure. However, few patients will be resectable at diagnosis, with a ... 11/25/2016
Megan K Applewhite, Michael G White, Jennifer Tseng, Maryam K Mohammed, Frederic Mercier, Edwin L Kaplan, Peter Angelos, Tamara Vokes, Raymon H Grogan Normohormonal primary hyperparathyroidism is a distinct form of primary hyperparathyroidism CONCLUSION: Normohormonal primary hyperparathyroidism represents 22.5% of our primary hyperparathyroidism population, which is greater than reported previously. It is a distinct disease process from classic primary hyperparathyroidism in presentation, imaging, and operative findings. More hyperplasi... 11/22/2016
Mariam F Eskander, Susanna W L de Geus, Gyulnara G Kasumova, Sing Chau Ng, Waddah Al-Refaie, Gamze Ayata, Jennifer F Tseng Evolution and impact of lymph node dissection during pancreaticoduodenectomy for pancreatic cancer CONCLUSION: Contemporary patients have an adequate number of nodes examined during standard pancreaticoduodenectomy. This, along with rising rates of N1 cancer detection and improved survival for both node-positive and node-negative patients, suggest more accurate classification of lymph node status... 11/21/2016
Hadas Alfandary, Daniel Landau Future considerations based on the information from Barrter's and Gitelman's syndromes PURPOSE OF REVIEW: Bartter and Gitelman syndromes are typical normotensive salt losing hypokalaemic tubulopathies. Their pathogenesis was gradually deciphered in the past 5 decades, first by typical salt balance studies and histopathology, followed by genetic characterization and discovery of the af... 11/1/2016
Cameron W Swanick, Katherine O Castle, Sastry Vedam, Mark F Munsell, Lehendrick M Turner, Gaiane M Rauch, Anuja Jhingran, Patricia J Eifel, Ann H Klopp Comparison of Computed Tomography- and Magnetic Resonance Imaging-based Clinical Target Volume Contours at Brachytherapy for Cervical Cancer CONCLUSIONS: We recommend MRI-based brachytherapy planning for patients with tumors >5 cm and parametrial invasion on MRI at diagnosis and for those with a high BMI. 10/30/2016
Yuanshui Zheng, Yixiu Kang, Omar Zeidan, Niek Schreuder An end-to-end assessment of range uncertainty in proton therapy using animal tissues Accurate assessment of range uncertainty is critical in proton therapy. However, there is a lack of data and consensus on how to evaluate the appropriate amount of uncertainty. The purpose of this study is to quantify the range uncertainty in various treatment conditions in proton therapy, using tra... 10/27/2016
Mariam F Eskander, Lindsay A Bliss, Ellen P McCarthy, Susanna W L de Geus, Sing Chau Ng, Deborah Nagle, James R Rodrigue, Jennifer F Tseng Massachusetts Healthcare Reform and Trends in Emergent Colon Resection CONCLUSIONS: There was a unique and sustained decline in the rate of emergent colon resection among publically insured and uninsured patients after 2006 in Massachusetts, in contradistinction to the national pattern, suggesting improved access to care associated with health insurance expansion. The ... 10/18/2016
Jared Andrew Shenson, Ryan Christopher Adams, S Toufeeq Ahmed, Anderson Spickard Formation of a New Entity to Support Effective Use of Technology in Medical Education: The Student Technology Committee CONCLUSIONS: Students should have an integral role in advancing medical education technology to improve training for 21st-century physicians. The student technology committee model provides a framework for this integration, can be readily implemented at other institutions, and creates immediate valu... 10/13/2016
Mariam F Eskander, Emily F Schapira, Lindsay A Bliss, Nikki M Burish, Abhishek Tadikonda, Sing Chau Ng, Jennifer F Tseng Keeping it in the family: the impact of marital status and next of kin on cancer treatment and survival CONCLUSIONS: Marriage status was associated with improved outcomes for certain cancers whereas familial relationship with NOK was not. 10/8/2016
Jared A Shenson, Jennifer N Craig, Sarah L Rohde Effect of Preoperative Counseling on Hospital Length of Stay and Readmissions after Total Laryngectomy Objective Total laryngectomy (TL) is a high-cost procedure with patients at risk for significant postoperative health care use. Face-to-face preoperative counseling provided by speech-language pathologists is a relatively inexpensive intervention that may improve care quality and decrease costs. We ... 9/29/2016
Cameron W Swanick, Pamela K Allen, Randa Tao, Adenike M Olanrewaju, Jordan R Sutton, Steven H Lin, James Welsh, Prajnan Das, Joe Y Chang, Christopher H Crane, Daniel R Gomez Incidence and predictors of chest wall toxicity after high-dose radiation therapy in 15 fractions CONCLUSIONS: Hypofractionated RT with 15 fraction regimens results in an acceptable incidence of CW toxicity, specifically CW pain. We recommend a dose constraint of V40 <150 cm³ to minimize this adverse event. 9/18/2016
Sjors Klompmaker, Desley M van Zoggel, Ammara A Watkins, Mariam F Eskander, Jennifer F Tseng, Marc G Besselink, A James Moser Nationwide Evaluation of Patient Selection for Minimally Invasive Distal Pancreatectomy Using American College of Surgeons' National Quality Improvement Program CONCLUSIONS: Current selection factors for ODP or MIDP (benign disease, tumor size, and BMI) do not mitigate the risk of major morbidity. We found no evidence that MIDP should be avoided based on tumor etiology or size, BMI, or patient physical status. 9/9/2016
Kathleen N Moore, James J Java, Katrina N Slaughter, Peter G Rose, Rachelle Lanciano, Paul A DiSilvestro, J Tate Thigpen, Yi-Chun Lee, Krishnansu S Tewari, Junzo Chino, Shelly M Seward, David S Miller, Ritu Salani, David H Moore, Frederick B Stehman Is age a prognostic biomarker for survival among women with locally advanced cervical cancer treated with chemoradiation? An NRG Oncology/Gynecologic Oncology Group ancillary data analysis CONCLUSION: This represents a large analysis of patients treated for LACC with chemo/radiation, approximately 20% of whom were >60years of age. Older patients, had higher rates of incomplete brachytherapy which is not explained by collected toxicity data. Age did not adversely impact completion of c... 8/21/2016
Asim Amin, David H Lawson, April K S Salama, Henry B Koon, Troy Guthrie, Sajeve S Thomas, Steven J O'Day, Montaser F Shaheen, Bin Zhang, Stephen Francis, F Stephen Hodi Phase II study of vemurafenib followed by ipilimumab in patients with previously untreated BRAF-mutated metastatic melanoma CONCLUSIONS: VEM (960 mg twice daily for 6 weeks) followed by IPI 10 mg/kg has a manageable safety profile. The benefits/risks of BRAF inhibitors followed by immunotherapy should be evaluated further in light of continuing developments in treatment options for metastatic melanoma. 8/18/2016
Gyulnara G Kasumova, Mariam F Eskander, Tara S Kent, Sing Chau Ng, A James Moser, Muneeb Ahmed, Douglas K Pleskow, Mark P Callery, Jennifer F Tseng Hemorrhage after pancreaticoduodenectomy: does timing matter? CONCLUSIONS: Hemorrhage following pancreaticoduodenectomy remains common, resulting in significantly increased mortality. Hemorrhage during the second post-operative week carries approximately double the mortality of early bleeding, suggesting different etiologies requiring differing treatment appro... 8/16/2016
Lindsay A Bliss, Mariam F Eskander, Tara S Kent, Ammara A Watkins, Susanna W L de Geus, Alessandra Storino, Sing Chau Ng, Mark P Callery, A James Moser, Jennifer F Tseng Early surgical bypass versus endoscopic stent placement in pancreatic cancer INTRODUCTION: The optimal treatment for biliary obstruction in pancreatic cancer remains controversial between surgical bypass and endoscopic stenting. 8/4/2016
Megan E Miller, Alexandra Kyrillos, Katharine Yao, Olga Kantor, Jennifer Tseng, David J Winchester, Lawrence N Shulman Utilization of Axillary Surgery for Patients With Ductal Carcinoma In Situ: A Report From the National Cancer Data Base CONCLUSIONS: Use of SLNB for DCIS is high with mastectomy, and nearly one fifth of the lumpectomy patients underwent SLNB. However, the performance of AS was strongly associated with the likelihood of upstaging in both groups, suggesting that surgical judgment plays an important role in this decisio... 6/24/2016
Cameron W Swanick, Xiudong Lei, Simona F Shaitelman, Pamela J Schlembach, Elizabeth S Bloom, Michelle C Fingeret, Eric A Strom, Welela Tereffe, Wendy A Woodward, Michael C Stauder, Tomas Dvorak, Alastair M Thompson, Thomas A Buchholz, Benjamin D Smith Longitudinal analysis of patient-reported outcomes and cosmesis in a randomized trial of conventionally fractionated versus hypofractionated whole-breast irradiation CONCLUSIONS: In this randomized trial, longitudinal outcomes did not appear to differ by treatment arm. Patient-reported functional and pain outcomes improved over time. These findings are relevant when counseling patients regarding decisions concerning radiotherapy. Cancer 2016. © 2016 American Ca... 6/16/2016
Cameron W Swanick, Benjamin D Smith Indications for adjuvant radiation therapy in breast cancer: a review of the evidence and recommendations for clinical practice Radiation therapy (RT) plays an important role in the curative management of all stages of breast cancer. The optimal application of adjuvant RT is an area of continuous investigation, and the indications for treatment are refined with each new trial. This article reviews the evidence for adjuvant R... 5/12/2016
Linda J Herrera, Stephen Brand, Andres Santos, Lilian L Nohara, Justin Harrison, Neil R Norcross, Stephen Thompson, Victoria Smith, Carolina Lema, Armando Varela-Ramirez, Ian H Gilbert, Igor C Almeida, Rosa A Maldonado Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi CONCLUSIONS/SIGNIFICANCE: Taken together, our data point out to the potential use of NMT inhibitors as anti-T. cruzi chemotherapy. 4/30/2016
Mary Linton B Peters, Jennifer F Tseng, Rebecca A Miksad Genetic Testing in Pancreatic Ductal Adenocarcinoma: Implications for Prevention and Treatment PURPOSE: This article reviews the progress to date and future directions for investigation of germline and somatic genetic testing to inform pancreatic adenocarcinoma (PDAC) treatment, screening, and prevention strategies. 4/5/2016
Raquibul Hannan, Vasu Tumati, Xian-Jin Xie, L Chinsoo Cho, Brian D Kavanagh, Jeffrey Brindle, David Raben, Akash Nanda, Susan Cooley, D W Nathan Kim, David Pistenmaa, Yair Lotan, Robert Timmerman Stereotactic body radiation therapy for low and intermediate risk prostate cancer-Results from a multi-institutional clinical trial CONCLUSION: SBRT treatment results in excellent biochemical control rates at 5 years for LR and IR PCa patients although doses greater than 47.5 Gy in five fractions led to increased severe late toxicity. 4/2/2016
Adnan S Hussaini, John J Dombrowski, E Stephen Bolesta, Ronald J Walker, Mark A Varvares Esthesioneuroblastoma with bilateral metastases to the parotid glands CONCLUSION: This case illustrates that delayed metastases in the setting of ENB are not limited to the cervical lymph nodes and, in rare instances, may involve the parotid glands. Surveillance should include the parotid lymph node basin with a high clinical index of suspicion in the setting of parot... 3/31/2016
Justin W Garyu, Mohamed Uduman, Alex Stewart, Jinxiu Rui, Songyan Deng, Jared Shenson, Matt M Staron, Susan M Kaech, Steven H Kleinstein, Kevan C Herold Characterization of Diabetogenic CD8+ T Cells: IMMUNE THERAPY WITH METABOLIC BLOCKADE Type 1 diabetes mellitus is caused by the killing of insulin-producing β cells by CD8+T cells. The disease progression, which is chronic, does not follow a course like responses to conventional antigens such as viruses, but accelerates as glucose tolerance deteriorates. To identify the unique featu... 3/20/2016
Jakub Zieg, Lucie Gonsorcikova, Daniel Landau Current views on the diagnosis and management of hypokalaemia in children CONCLUSION: Understanding the pathophysiology of hypokalaemic states, along with a detailed medical history, physical examination and specific laboratory tests are required for proper diagnosis and appropriate treatment. 3/15/2016
Jared A Shenson, Ebone Ingram, Nadja Colon, Gretchen Purcell Jackson Application of a Consumer Health Information Needs Taxonomy to Questions in Maternal-Fetal Care Pregnancy is a time when expectant mothers may have numerous questions about their unborn children, especially when congenital anomalies are diagnosed prenatally. We sought to characterize information needs of pregnant women seen in the Vanderbilt Children's Hospital Fetal Center. Participants recor... 3/10/2016
Ammara A Watkins, Lindsay A Bliss, Danielle B Cameron, Mariam F Eskander, Jennifer F Tseng, Tara S Kent Deconstructing the "July Effect" in Operative Outcomes: A National Study This study analyzes the relationship between hospital teaching status, failure to rescue, and time of year in select gastrointestinal operations. Procedure codes for laparoscopic cholecystectomy, colectomy, and pancreatectomy were queried from the Nationwide Inpatient Sample (2004-2011). Failure to ... 3/3/2016
Nergiz Dagoglu, Mark Callery, James Moser, Jennifer Tseng, Tara Kent, Andrea Bullock, Rebecca Miksad, Joseph D Mancias, Anand Mahadevan Stereotactic Body Radiotherapy (SBRT) Reirradiation for Recurrent Pancreas Cancer CONCLUSIONS: SBRT can be a useful and tolerable option for patients with recurrent pancreas cancer after prior radiation. 2/27/2016
Daniel Landau, Harry J Hirsch, Varda Gross-Tsur Case report: severe asymptomatic hyponatremia in Prader-Willi Syndrome CONCLUSION: Hyponatremia should be suspected in children with Prader-Willi syndrome, especially in infants with severe failure to thrive. Further studies are needed to determine the pathophysiology of hyponatremia in this syndrome. 2/19/2016
Daniel Landau, Evgenia Gurevich, Levana Sinai-Treiman, Hannah Shalev Accentuated hyperparathyroidism in type II Bartter syndrome CONCLUSIONS: PTH, serum Pi levels, and urinary threshold for Pi reabsorption are significantly elevated in type II vs. type IV BS, suggesting a PTH resistance state. This may be a response to more severe long-standing hypercalciuria, leading to a higher rate of nephrocalcinosis in BS-II. 2/10/2016
María del Mar Pérez, Razvan Ghinea, María José Rivas, Ana Yebra, Ana María Ionescu, Rade D Paravina, Luis Javier Herrera Development of a customized whiteness index for dentistry based on CIELAB color space CONCLUSION: The validation experiments under laboratory and typical clinical conditions revealed that the proposed index WID outperformed previous indices, being the only CIELAB-based index developed for evaluation of whiteness in dentistry. 1/19/2016
Wen C Hsi, Andries N Schreuder, Omar Zeidan Utilization of optical tracking to assess efficacy of intracranial immobilization techniques in proton therapy We present a quantitative methodology to measure head interfraction movements within intracranial masks of commercial immobilization devices used for proton radiotherapy. A three-points tracking (3PtTrack) method was developed to measure the mask location for each treatment field over an average of ... 12/25/2015
Michael Phillips, Thomas L Bauer, Renee N Cataneo, Cassie Lebauer, Mayur Mundada, Harvey I Pass, Naren Ramakrishna, William N Rom, Eric Vallières Blinded Validation of Breath Biomarkers of Lung Cancer, a Potential Ancillary to Chest CT Screening CONCLUSIONS: Breath VOC mass ion biomarkers identified lung cancer in a separate independent cohort, in a blinded replicated study. Combining breath biomarkers with chest CT could potentially improve the sensitivity and specificity of lung cancer screening. 12/25/2015
Nosayaba Osazuwa-Peters, Kara M Christopher, Adnan S Hussaini, Anit Behera, Ronald J Walker, Mark A Varvares Predictors of stage at presentation and outcomes of head and neck cancers in a university hospital setting CONCLUSION: Disparities, such as race and health insurance status, are important predictors of stage at presentation of patients with head and neck cancer. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1826-E1832, 2016. 12/24/2015
Daniel K Ho, Razvan Ghinea, Luis J Herrera, Nikola Angelov, Rade D Paravina Color Range and Color Distribution of Healthy Human Gingiva: a Prospective Clinical Study The aim of this study is to compile a comprehensive database on color range and color distribution of healthy human gingiva by age, gender and ethnicity. Spectral reflection of keratinized gingiva at upper central incisors was measured by spectroradiometer and converted into CIELAB values. Lightness... 12/23/2015
Ariel Troib, Mayan Guterman, Ralph Rabkin, Daniel Landau, Yael Segev Endurance exercise and growth hormone improve bone formation in young and growth-retarded chronic kidney disease rats CONCLUSIONS: Treadmill exercise improves tibial bone linear growth, as well as growth plate local IGF-I. When combined with GH treatment, running exercise shows beneficial effects on trabecular bone formation, suggesting the potential benefit of this combination for CKD-related short stature and bon... 11/13/2015
Lindsay A Bliss, Lillias H Maguire, Zeling Chau, Catherine J Yang, Deborah A Nagle, Andrew T Chan, Jennifer F Tseng Readmission After Resections of the Colon and Rectum: Predictors of a Costly and Common Outcome CONCLUSIONS: Readmissions rates after colorectal surgery remain common and costly. Nonprivate insurance, IBD, and high hospital volume are significantly associated with readmission. 11/7/2015
Anand Mahadevan, Nergiz Dagoglu, Joseph Mancias, Kristin Raven, Khalid Khwaja, Jennifer F Tseng, Kimmie Ng, Peter Enzinger, Rebecca Miksad, Andrea Bullock, Amy Evenson Stereotactic Body Radiotherapy (SBRT) for Intrahepatic and Hilar Cholangiocarcinoma CONCLUSIONS: SBRT is an effective and reasonably safe local therapy option for unresectable intrahepatic or hilar cholangiocarcinoma. 10/31/2015
Randa Tao, Sunil Krishnan, Priya R Bhosale, Milind M Javle, Thomas A Aloia, Rachna T Shroff, Ahmed O Kaseb, Andrew J Bishop, Cameron W Swanick, Eugene J Koay, Howard D Thames, Theodore S Hong, Prajnan Das, Christopher H Crane Ablative Radiotherapy Doses Lead to a Substantial Prolongation of Survival in Patients With Inoperable Intrahepatic Cholangiocarcinoma: A Retrospective Dose Response Analysis CONCLUSION: Delivery of higher doses of RT improves LC and OS in inoperable IHCC. A BED greater than 80.5 Gy seems to be an ablative dose of RT for large IHCCs, with long-term survival rates that compare favorably with resection. 10/28/2015
Anand Mahadevan, Nergiz Dagoglu, Jennifer F Tseng, Khalid Khawaja, Amy Evenson Therapeutic Potential of Adjuvant Stereotactic Body Radiotherapy for Gallbladder Cancer Surgical treatment remains the only curative treatment for gallbladder cancer. However, even after liver resection, locoregional failure seems to be a significant problem. While there is no Level I evidence, multiple studies have shown benefit for adjuvant radiation in high-risk patients. After exte... 10/3/2015
Susanna W L de Geus, Lindsay A Bliss, Mariam F Eskander, Sing Chau Ng, Alexander L Vahrmeijer, Anand Mahadevan, Tara S Kent, A James Moser, Mark P Callery, Bert A Bonsing, Jennifer F Tseng A Tale of Two Cities: Reconsidering Adjuvant Radiation in Pancreatic Cancer Care Adjuvant chemotherapy plays a critical role in the treatment of resected pancreatic cancer patients. However, the role of adjuvant radiation remains controversial. This study compares survival between resected pancreatic cancer patients who received adjuvant radiation and no adjuvant radiation. Medi... 10/3/2015
Daniel Landau, Shannon Stockton An unusual cause of suicidal ideations While the differential for suicidal ideations is broad, it is known that pathologic brain issues are a cause. Here, a case is presented of a gentleman who had an unusual growth into his frontal lobe leading to the suicidal ideations. The fact that he is chronically immunosuppressed likely led to thi... 10/1/2015
Razvan Ghinea, Oscar Pecho, Luis Javier Herrera, Ana Maria Ionescu, Juan de la Cruz Cardona, María Purificación Sanchez, Rade D Paravina, María del Mar Perez Predictive algorithms for determination of reflectance data from quantity of pigments within experimental dental resin composites CONCLUSIONS: Within the framework of this pilot study, the nonlinear predictive models developed allow the prediction, with a high degree of accuracy, of the reflectance spectrum of the experimental dental resin composites. 9/3/2015
Timothy J Daskivich, Dinchen A Jardine, Jennifer Tseng, Ricardo Correa, Brian C Stagg, Kristin M Jacob, Jared L Harwood Promotion of Wellness and Mental Health Awareness Among Physicians in Training: Perspective of a National, Multispecialty Panel of Residents and Fellows CONCLUSIONS: A multispecialty, national panel of trainees identified actionable goals to broaden efforts in programs and sponsoring institutions to promote resident wellness and mental health awareness. Engagement of all stakeholders within the graduate medical education community will be critical t... 7/29/2015
Lindsay A Bliss, Catherine J Yang, Mariam F Eskander, Susanna W L de Geus, Mark P Callery, Tara S Kent, A James Moser, Steven D Freedman, Jennifer F Tseng Surgical management of chronic pancreatitis: current utilization in the United States CONCLUSION: Chronic pancreatitis leads to numerous inpatient readmissions, but surgical intervention only occurs in a minority of cases. Complicated patients are more likely to undergo surgery. The complexities of chronic pancreatitis management warrant early multidisciplinary evaluation and ongoing... 7/29/2015
Jared A Shenson, Robert M Cronin, Sharon E Davis, Qingxia Chen, Gretchen Purcell Jackson Rapid growth in surgeons' use of secure messaging in a patient portal CONCLUSIONS: This study demonstrates rapid adoption of online secure messaging across surgical specialties with significant growth in its use for outpatient interaction. Some specialties, particularly those with long-term follow-up, interacted with patients more through secure messaging than in pers... 7/1/2015
Mariam F Eskander, Lindsay A Bliss, Osman K Yousafzai, Susanna W L de Geus, Sing Chau Ng, Mark P Callery, Tara S Kent, A James Moser, Khalid Khwaja, Jennifer F Tseng A nationwide assessment of outcomes after bile duct reconstruction CONCLUSION: This is the first national description of BDRs using a large database. In this diverse sampling, both procedure indication and patient characteristics influence morbidity and mortality. 6/23/2015
Lior Z Braunstein, Ming-Hui Chen, Daniel E Dosoretz, Sharon A Salenius, Michael J Katin, Akash Nanda, Anthony V D'Amico Whole Pelvis Versus Prostate-Only Radiotherapy With or Without Short-Course Androgen Deprivation Therapy and Mortality Risk CONCLUSION: Treatment with WPRT or short-course ADT is associated with a decreased risk of ACM, although a combination of the two does not yield greater benefit. This observation suggests a shared mechanism for this risk reduction, which we hypothesize to be via the treatment of micrometastatic dise... 5/25/2015
Alexander N Starodub, Allyson J Ocean, Manish A Shah, Michael J Guarino, Vincent J Picozzi, Linda T Vahdat, Sajeve S Thomas, Serengulam V Govindan, Pius P Maliakal, William A Wegener, Steven A Hamburger, Robert M Sharkey, David M Goldenberg First-in-Human Trial of a Novel Anti-Trop-2 Antibody-SN-38 Conjugate, Sacituzumab Govitecan, for the Treatment of Diverse Metastatic Solid Tumors CONCLUSIONS: Sacituzumab govitecan had acceptable toxicity and encouraging therapeutic activity in patients with difficult-to-treat cancers. The 8 and 10 mg/kg doses were selected for phase II studies. 5/7/2015
Oded Scheuerman, Daniel Landau, Michael Schwarz, Vered Hoffer, Nufar Marcus, Liat Ashkenazi Hoffnung, Itzhak Levy Cervical Discitis in Children Cervical discitis, though rare, should be included in the differential diagnosis of torticollis, neck pain and neurodevelopmental regression in motor skills in children and infants. Magnetic resonance imaging is the diagnostic method of choice. Treatment should be conservative with antibiotics only.... 4/19/2015
Rade D Paravina, Razvan Ghinea, Luis J Herrera, Alvaro D Bona, Christopher Igiel, Mercedes Linninger, Maiko Sakai, Hidekazu Takahashi, Esam Tashkandi, Maria del Mar Perez Color difference thresholds in dentistry CONCLUSION: A 50:50% perceptibility and ATs were significantly different. The same is true for differences between two color difference formulas ΔE00 /ΔEab . Observer groups and sites showed high level of statistical difference in all thresholds. 4/18/2015
Catherine J Yang, Lindsay A Bliss, Steven D Freedman, Sunil Sheth, Charles M Vollmer, Sing Chau Ng, Mark P Callery, Jennifer F Tseng Surgery for chronic pancreatitis: the role of early surgery in pain management CONCLUSIONS: Results from a single institution analysis suggest early surgical intervention of 26.5 months or less of diagnosis is associated with improved pain control, and optimal timing for surgery may be earlier than previously thought. 4/18/2015
Chantal Loirat, Fadi Fakhouri, Gema Ariceta, Nesrin Besbas, Martin Bitzan, Anna Bjerre, Rosanna Coppo, Francesco Emma, Sally Johnson, Diana Karpman, Daniel Landau, Craig B Langman, Anne-Laure Lapeyraque, Christoph Licht, Carla Nester, Carmine Pecoraro, Magdalena Riedl, Nicole C A J van de Kar, Johan Van de Walle, Marina Vivarelli, Véronique Frémeaux-Bacchi, HUS International An international consensus approach to the management of atypical hemolytic uremic syndrome in children Atypical hemolytic uremic syndrome (aHUS) emerged during the last decade as a disease largely of complement dysregulation. This advance facilitated the development of novel, rational treatment options targeting terminal complement activation, e.g., using an anti-C5 antibody (eculizumab). We review t... 4/11/2015
X Sharon Qi, Anand Santhanam, John Neylon, Yugang Min, Tess Armstrong, Ke Sheng, Robert J Staton, Jason Pukala, Andrew Pham, Daniel A Low, Steve P Lee, Michael Steinberg, Rafael Manon, Allen M Chen, Patrick Kupelian Near Real-Time Assessment of Anatomic and Dosimetric Variations for Head and Neck Radiation Therapy via Graphics Processing Unit-based Dose Deformation Framework CONCLUSIONS: A systematic analysis of anatomic variations in the H&N region and their dosimetric consequences is critical in improving treatment efficacy. Nearly real-time assessment of anatomic and dosimetric variations is feasible using the GPU-based DIR framework. Clinical implementation of this ... 4/8/2015
Miguel A Vasquez, Eva Iniguez, Umashankar Das, Stephen M Beverley, Linda J Herrera, Jonathan R Dimmock, Rosa A Maldonado Evaluation of α,β-unsaturated ketones as antileishmanial agents In this study, we assessed the antileishmanial activity of 126 α,β-unsaturated ketones. The compounds NC901, NC884, and NC2459 showed high leishmanicidal activity for both the extracellular (50% effective concentration [EC50], 456 nM, 1,122 nM, and 20 nM, respectively) and intracellular (EC50, 1,8... 3/25/2015
Cameron W Swanick, Katherine O Castle, Laura A Rechner, Gaiane M Rauch, Anuja Jhingran, Patricia J Eifel, Ann H Klopp Optimizing packing contrast for MRI-based intracavitary brachytherapy planning for cervical cancer CONCLUSIONS: Gauze impregnated with ultrasound gel, conjugated estrogens cream mixed with ultrasound gel, and gadolinium allowed for a significant difference in MRI signal intensity between the packing and the cervix. With respect to both the cervix and the applicator, ultrasoundgel-impregnated gauz... 1/27/2015
Shelly M Seward, Ira Winer Primary debulking surgery and neoadjuvant chemotherapy in the treatment of advanced epithelial ovarian carcinoma Surgery and chemotherapy are the standard of care for epithelial ovarian cancer, and it is well established that survival outcomes are improved when the surgery results in no or optimal (less than 1 cm) residual disease. However, for patients with bulky disease that may require extensive or radical ... 1/19/2015
Ami B Raval, Jennifer Salluzzo, Tomas Dvorak, Lori Lyn Price, John E Mignano, Julian K Wu Salvage Gamma Knife Radiosurgery after failed management of bilateral trigeminal neuralgia CONCLUSION: Bilateral TN is rare, and effective treatment is crucial to improve the quality of life of those afflicted. Salvage GKRS is a reasonable treatment modality for individuals with bilateral TN. 12/20/2014
Cameron W Swanick, Steven H Lin, Jordan Sutton, Nilan S Naik, Pamela K Allen, Lawrence B Levy, Zhongxing Liao, James W Welsh, Ritsuko Komaki, Joe Y Chang, Daniel R Gomez Use of simultaneous radiation boost achieves high control rates in patients with non-small-cell lung cancer who are not candidates for surgery or conventional chemoradiation CONCLUSION: Hypofractionated IMRT+SIB is a viable option for some patients with NSCLC, with little high-grade toxicity overall. Nearly all local failures occurred within the higher dose region, implying strong radioresistance or some other mechanism for recurrence in a subgroup of patients. 12/4/2014
Barbora Novotna, Vladimir Koblizek, Jaromir Zatloukal, Marek Plutinsky, Karel Hejduk, Zuzana Zbozinkova, Jiri Jarkovsky, Ondrej Sobotik, Tomas Dvorak, Petr Safranek Czech multicenter research database of severe COPD CONCLUSION: The establishment of the database is a useful step in improving care for COPD subjects. Additionally, it will serve as a source of data elucidating the natural course of COPD, comorbidities, and overall impact on the patients. Moreover, it will provide information on the diverse course o... 11/25/2014
Lindsay A Bliss, Catherine J Yang, Tara S Kent, Sing Chau Ng, Jonathan F Critchlow, Jennifer F Tseng Appendicitis in the modern era: universal problem and variable treatment CONCLUSIONS: Laparoscopic appendectomy is increasing but is unevenly deployed across patient groups. Appendectomy patients were increasingly older, with more comorbidities and with increasing rates of obesity. Black patients and patients with public insurance had less utilization of laparoscopy and ... 10/9/2014
Cristina Saura, Jose A Garcia-Saenz, Binghe Xu, Wael Harb, Rebecca Moroose, Timothy Pluard, Javier Cortés, Corinne Kiger, Caroline Germa, Kongming Wang, Miguel Martin, José Baselga, Sung-Bae Kim Safety and efficacy of neratinib in combination with capecitabine in patients with metastatic human epidermal growth factor receptor 2-positive breast cancer CONCLUSION: Neratinib in combination with capecitabine had a manageable toxicity profile and showed promising antitumor activity in patients with HER2-positive metastatic breast cancer pretreated with trastuzumab and lapatinib. 10/8/2014
Galina Ling, Daniel Landau, Carsten Bergmann, Esther Maor, Baruch Yerushalmi Neonatal ascites in autosomal recessive polycystic kidney disease (ARPKD) CONCLUSION: ARPKD should be considered in differential diagnosis of neonatal ascites. 9/25/2014
Victoria Lafuente, Luis J Herrera, María del Mar Pérez, Jesús Val, Ignacio Negueruela Firmness prediction in Prunus persica 'Calrico' peaches by visible/short-wave near infrared spectroscopy and acoustic measurements using optimised linear and non-linear chemometric models CONCLUSION: These results indicated that the proposed mutual-information-based variable selection algorithm was a powerful tool for the selection of the most relevant variables. 9/17/2014
Jennifer Tseng, Birat Dhungel, Jane K Mills, Brian S Diggs, Roshanthi Weerasinghe, Jeanine Fortino, John T Vetto Merkel cell carcinoma: what makes a difference? CONCLUSIONS: Lymph node evaluation is an important component to MCC treatment. The role of adjuvant radiation and chemotherapy needs further evaluation. 8/26/2014
Lindsay A Bliss, Elan R Witkowski, Catherine J Yang, Jennifer F Tseng Outcomes in operative management of pancreatic cancer Pancreatic cancer is a highly lethal malignancy that often presents at an advanced stage. Surgical resection can prolong survival and offers the only potential for cure. However, pancreatectomy is associated with significant morbidity and mortality. This article reviews perioperative outcomes, post-... 8/12/2014
Qiaoqiao Li, Cameron W Swanick, Pamela K Allen, Daniel R Gomez, James W Welsh, Zhongxing Liao, Peter A Balter, Joe Y Chang Stereotactic ablative radiotherapy (SABR) using 70 Gy in 10 fractions for non-small cell lung cancer: exploration of clinical indications CONCLUSIONS: SABR with 70 Gy in 10 fractions appears to achieve excellent local control and acceptable toxicity for clinically challenging cases with improved tolerance of the chest wall and brachial plexus as compared with 50 Gy in 4 fractions. This regimen may not be suitable in patients with tumo... 8/11/2014
Wen C Hsi, Aaron Law, Andreas N Schreuder, Omar A Zeidan Utilization of optical tracking to validate a software-driven isocentric approach to robotic couch movements for proton radiotherapy CONCLUSIONS: The authors present an optical tracking methodology to quantify for software-driven isocentric movements of robotic couches. By applying proper RIS correction for misaligned GeoIso and RadIso for each couch, and the RadIso shifts for a moving gantry, residual target displacements for is... 8/4/2014
Susan V Ellor, Teri Ann Pagano-Young, Nicholas G Avgeropoulos Glioblastoma: background, standard treatment paradigms, and supportive care considerations Glioblastoma is a brain tumor condition marked by rapid neurological and clinical demise, resulting in disproportionate disability for those affected. Caring for this group of patients is complex, intense, multidisciplinary in nature, and fraught with the need for expensive treatments, surveillance ... 7/22/2014
Catherine J Yang, Lindsay A Bliss, Emily F Schapira, Steven D Freedman, Sing Chau Ng, John A Windsor, Jennifer F Tseng Systematic review of early surgery for chronic pancreatitis: impact on pain, pancreatic function, and re-intervention CONCLUSIONS: Data from this study supports considering early surgery for pain management in patients with chronic pancreatitis, with the potential of a reduced risk of pancreatic insufficiency and the need for further intervention. Further prospective randomized studies are warranted comparing early... 6/20/2014
D W Nathan Kim, L Chinsoo Cho, Christopher Straka, Alana Christie, Yair Lotan, David Pistenmaa, Brian D Kavanagh, Akash Nanda, Patrick Kueplian, Jeffrey Brindle, Susan Cooley, Alida Perkins, David Raben, Xian-Jin Xie, Robert D Timmerman Predictors of rectal tolerance observed in a dose-escalated phase 1-2 trial of stereotactic body radiation therapy for prostate cancer CONCLUSION: Caution is advised when considering high-dose SBRT for treatment of tumors near bowel structures, including prostate cancer. Threshold dose constraints developed from physiologic principles are defined, and if respected can minimize risk of severe rectal toxicity. 6/15/2014
Lindsay A Bliss, Catherine J Yang, Zeling Chau, Sing Chau Ng, David W McFadden, Tara S Kent, A James Moser, Mark P Callery, Jennifer F Tseng Patient selection and the volume effect in pancreatic surgery: unequal benefits? BACKGROUND: The volume effect in pancreatic surgery is well established. Regionalization to high-volume centres has been proposed. The effect of this proposal on practice patterns is unknown. 6/7/2014
Suresh Rana, ChihYao Cheng, Yuanshui Zheng, Wen Hsi, Omar Zeidan, Niek Schreuder, Carlos Vargas, Gary Larson Dosimetric study of uniform scanning proton therapy planning for prostate cancer patients with a metal hip prosthesis, and comparison with volumetric-modulated arc therapy The main purposes of this study were to 1) investigate the dosimetric quality of uniform scanning proton therapy planning (USPT) for prostate cancer patients with a metal hip prosthesis, and 2) compare the dosimetric results of USPT with that of volumetric-modulated arc therapy (VMAT). Proton plans ... 6/4/2014
Sally Johnson, Jelena Stojanovic, Gema Ariceta, Martin Bitzan, Nesrin Besbas, Michelle Frieling, Diana Karpman, Daniel Landau, Craig Langman, Christoph Licht, Carmine Pecoraro, Magdalena Riedl, Ekaterini Siomou, Nicole van de Kar, Johan Vande Walle, Chantal Loirat, C Mark Taylor An audit analysis of a guideline for the investigation and initial therapy of diarrhea negative (atypical) hemolytic uremic syndrome CONCLUSIONS: This audit provides a snapshot of the early outcome of a group of children with aHUS in the months prior to more widespread use of eculizumab. 5/13/2014
Naren Ramakrishna, Sarah Temin, Sarat Chandarlapaty, Jennie R Crews, Nancy E Davidson, Francisco J Esteva, Sharon H Giordano, Ana M Gonzalez-Angulo, Jeffrey J Kirshner, Ian Krop, Jennifer Levinson, Shanu Modi, Debra A Patt, Edith A Perez, Jane Perlmutter, Eric P Winer, Nancy U Lin Recommendations on disease management for patients with advanced human epidermal growth factor receptor 2-positive breast cancer and brain metastases: American Society of Clinical Oncology clinical practice guideline PURPOSE: To provide formal expert consensus-based recommendations to practicing oncologists and others on the management of brain metastases for patients with human epidermal growth factor receptor 2 (HER2) -positive advanced breast cancer. 5/7/2014
Sharon H Giordano, Sarah Temin, Jeffrey J Kirshner, Sarat Chandarlapaty, Jennie R Crews, Nancy E Davidson, Francisco J Esteva, Ana M Gonzalez-Angulo, Ian Krop, Jennifer Levinson, Nancy U Lin, Shanu Modi, Debra A Patt, Edith A Perez, Jane Perlmutter, Naren Ramakrishna, Eric P Winer, American Society of Clinical Oncology Systemic therapy for patients with advanced human epidermal growth factor receptor 2-positive breast cancer: American Society of Clinical Oncology clinical practice guideline PURPOSE: To provide evidence-based recommendations to practicing oncologists and others on systemic therapy for patients with human epidermal growth factor receptor 2 (HER2) -positive advanced breast cancer. 5/7/2014
Amish P Shah, Tomas Dvorak, Michael S Curry, Daniel J Buchholz, Sanford L Meeks Clinical evaluation of interfractional variations for whole breast radiotherapy using 3-dimensional surface imaging CONCLUSIONS: Daily alignment with 3D surface imaging was found to be valuable for reducing setup errors when comparing with patient alignment from skin marks. The result of the surface-based alignments specifically showed that alignment with skin marks was noticeably poor in the anteroposterior dire... 3/29/2014
Daniel Landau, Ruth Schreiber, Anya Kleinman, Alina Vodonos, Hannah Shalev Pediatric chronic kidney disease rates in Southern Israel are higher than reported CONCLUSIONS: p-CKD rates in our area are higher than reported and maybe even higher if asymptomatic populations are screened. Fifty percent of detected cases have CKD stage 1. This may contribute significantly to CKD beyond the pediatric age. 2/21/2014
Jennifer Tseng, Deborah E Citrin, Meryl Waldman, Donald E White, Steven A Rosenberg, James C Yang Thrombotic microangiopathy in metastatic melanoma patients treated with adoptive cell therapy and total body irradiation CONCLUSIONS: TMA occurs in approximately a third of patients treated with a lymphodepleting preparative chemotherapy regimen with TBI prior to autologous T cell therapy. The disease has a variable natural history, however, no patient developed end-stage renal failure. Successful management with supp... 1/30/2014
Debbie Wiezel, Mohammed Hani Assadi, Daniel Landau, Ariel Troib, Leonid Kachko, Ralph Rabkin, Yael Segev Impaired renal growth hormone JAK/STAT5 signaling in chronic kidney disease CONCLUSIONS: Despite known unaltered circulating GH levels, remnant kidneys of uremic growth retarded juvenile rats show impaired basal signaling along the GH-activated JAK2/STAT5 signaling pathway. This may well be a consequence of the reduced GHR level and the inhibitory effect of the increase in ... 1/28/2014
Edward J Arous, Theodore P McDade, Jillian K Smith, Sing Chau Ng, Mary E Sullivan, Ralph J Zottola, Paul J Ranauro, Shimul A Shah, Giles F Whalen, Jennifer F Tseng Electronic medical record: research tool for pancreatic cancer? CONCLUSIONS: These results suggest that cautious interpretation of administrative data rely only on ICD-9-CM diagnosis codes and clinical correlation through previously validated mechanisms. 12/12/2013
Jason Pukala, Sanford L Meeks, Robert J Staton, Frank J Bova, Rafael R Mañon, Katja M Langen A virtual phantom library for the quantification of deformable image registration uncertainties in patients with cancers of the head and neck CONCLUSIONS: It is essential that DIR algorithms be evaluated using a range of possible clinical scenarios for each treatment site. This work introduces a library of virtual phantoms intended to resemble real cases for interfraction head and neck DIR that may be used to estimate and compare the unce... 12/11/2013
Volkan Cetin, Bilal Piperdi, Venu Bathini, William V Walsh, Shakeeb Yunus, Jennifer F Tseng, Giles F Whalen, Wahid Y Wassef, Sidney P Kadish, Thomas J Fitzgerald, Christine Mikule, Yuxia Wang, Steven R Grossman A Phase II Trial of Cetuximab, Gemcitabine, 5-Fluorouracil, and Radiation Therapy in Locally Advanced Nonmetastatic Pancreatic Adenocarcinoma CONCLUSIONS: The combination of cetuximab, weekly gemcitabine and continuous infusion of 5-FU with radiotherapy was quite well tolerated with intriguing clinical benefit and survival results in carefully selected patients with locally advanced pancreatic adenocarcinoma. A trial with larger sample si... 12/7/2013
Zeling Chau, James K West, Zheng Zhou, Theodore McDade, Jillian K Smith, Sing-Chau Ng, Tara S Kent, Mark P Callery, A James Moser, Jennifer F Tseng Rankings versus reality in pancreatic cancer surgery: a real-world comparison CONCLUSIONS: The plethora of publicly available hospital ratings systems demonstrates heterogeneity. Volume remains a good but imperfect indicator of surgical outcomes. Further systematic investigation into which measures predict quality outcomes in pancreatic cancer surgery will benefit both patien... 11/20/2013
Nancy U Lin, Rachel A Freedman, Naren Ramakrishna, Jerry Younger, Anna Maria Storniolo, Jennifer R Bellon, Steven E Come, Rebecca S Gelman, Gordon J Harris, Mark A Henderson, Shannon M Macdonald, Anand Mahadevan, Emily Eisenberg, Jennifer A Ligibel, Erica L Mayer, Beverly Moy, April F Eichler, Eric P Winer A phase I study of lapatinib with whole brain radiotherapy in patients with Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer brain metastases Brain metastases are common in patients with advanced, Human Epidermal Growth Factor Receptor 2 (HER2)-positive breast cancer. We evaluated the maximum tolerated dose (MTD) and feasibility of lapatinib given concurrently with whole brain radiotherapy (WBRT). Eligible patients had (HER2)-positive bre... 11/8/2013
Nili Segal, Ehab Atamne, Ilan Shelef, Shorer Zamir, Daniel Landau Intracranial infection caused by spreading through the fossa naviclaris magna - a case report and review of the literature Fossa navicularis magna is a congenital anomaly representing persistent dehiscence of the basiocciput. This tract from the nasopharynx to the brain is common and carries a potential risk for infection. Nevertheless reports on such dissemination are very rare. We present a child with brain infection ... 10/24/2013
Ramesh B Batchu, Aamer M Qazi, Oksana V Gruzdyn, Assaad Semaan, Shelly M Seward, Sreedhar Chamala, Vasu B Dhulipala, David L Bouwman, Donald W Weaver, Scott A Gruber EZH2-shRNA-mediated upregulation of p21waf1/cip1 and its transcriptional enhancers with concomitant downmodulation of mutant p53 in pancreatic ductal adenocarcinoma CONCLUSION: Downregulation of mutant p53 with concomitant enhanced expression of p21(waf1/cip1) and its transcriptional trans-activators may contribute toward EZH2-mediated suppression of PDAC. 10/1/2013
Suresh Rana, Omar Zeidan, Eric Ramirez, Michael Rains, Junfang Gao, Yuanshui Zheng Measurements of lateral penumbra for uniform scanning proton beams under various beam delivery conditions and comparison to the XiO treatment planning system CONCLUSIONS: Lateral penumbra of uniform scanning proton beams depends on air gap, proton range, compensator thickness, and depth, whereas lateral penumbra is not dependent on modulation. The XiO TPS typically overpredicted lateral penumbra compared to measurements, within 1 mm for most cases, but t... 9/7/2013
Cameron W Swanick, Ana M Gaca, Caroline L Hollingsworth, Charles M Maxfield, Xiang Li, Ehsan Samei, Erik K Paulson, Matthew B McCarthy, Donald P Frush Comparison of conventional and simulated reduced-tube current MDCT for evaluation of suspected appendicitis in the pediatric population CONCLUSION: Simulated tube current-reduction technology provides for systematic evaluation of diagnostic thresholds. Application of this technology in the setting of suspected appendicitis shows that tube current can be reduced by at least 50% without significantly affecting diagnostic quality, desp... 8/27/2013
Daniel Landau, Evgenia Gurevich, Joseph Kapelushnik, Hannah Tamary, Ilan Shelef, Isaac Lazar Association between childhood nephrotic syndrome and hemophagocytic lymphohistiocytosis CONCLUSIONS: To our knowledge, this is the first report of NS antedating the presentation of HLH. 8/17/2013
Elizaveta Ragulin-Coyne, Elan R Witkowski, Zeling Chau, Daniel Wemple, Sing Chau Ng, Heena P Santry, Shimul A Shah, Jennifer F Tseng National trends in pancreaticoduodenal trauma: interventions and outcomes CONCLUSIONS: The utilization of operations for PDT has declined without affecting mortality, but operative morbidity increased significantly over the 12 years to 2009. The development of an evidence-based approach to invasive manoeuvres and an early multidisciplinary approach involving pancreatic su... 7/23/2013
Michael Phillips, Richard Byrnes, Renee N Cataneo, Anirudh Chaturvedi, Peter D Kaplan, Mark Libardoni, Vivek Mehta, Mayur Mundada, Urvish Patel, Naren Ramakrishna, Peter B Schiff, Xiang Zhang Detection of volatile biomarkers of therapeutic radiation in breath Breath testing could provide a rational tool for radiation biodosimetry because radiation causes distinct stress-producing molecular damage, notably an increased production of reactive oxygen species. The resulting oxidative stress accelerates lipid peroxidation of polyunsaturated fatty acids, liber... 6/25/2013
Jillian K Smith, Sing Chau Ng, Zheng Zhou, James E Carroll, Theodore P McDade, Shimul A Shah, Jennifer F Tseng Does increasing insurance improve outcomes for US cancer patients? CONCLUSIONS: Health insurance coverage at a community level appears to influence survival for patients with cancer. Additional investigations are needed to examine whether individual versus community associations exist and how best to surmount barriers to cancer care. 6/19/2013
Ariel Troib, Daniel Landau, Leonid Kachko, Ralph Rabkin, Yael Segev Epiphyseal growth plate growth hormone receptor signaling is decreased in chronic kidney disease-related growth retardation Linear growth retardation in children with chronic kidney disease (CKD) has been ascribed to insensitivity to growth hormone. This resistance state has been attributed to impaired growth hormone signaling through the JAK2/STAT5 pathway in liver and skeletal muscle leading to reduced insulin-like gro... 5/30/2013
Naren Ramakrishna, Kim A Margolin Multidisciplinary approach to brain metastasis from melanoma; local therapies for central nervous system metastases The overall treatment paradigm for melanoma brain metastases continues to evolve and reflects the relative radioresistance of this histology, as well as the effect of emerging systemic therapies with central nervous system (CNS) activity. Local therapies, including surgery, whole brain radiotherapy ... 5/30/2013
Yuval Cavari, Daniel Landau, Shaul Sofer, Tom Leibson, Isaac Lazar Organophosphate poisoning-induced acute renal failure CONCLUSIONS: Organophosphate poisoning can lead to renal failure, which, with proper treatment, may be reversible but, if left unattended, might aggravate the clinical course of the disease. Physicians should be aware of this rare complication. 5/4/2013
Wen C Hsi, Marcio Fagundes, Omar Zeidan, Eugen Hug, Niek Schreuder Image-guided method for TLD-based in vivo rectal dose verification with endorectal balloon in proton therapy for prostate cancer CONCLUSIONS: Our results show that image-guided TLD-based in vivo dosimetry for rectal dose verification can be perfomed reliably and reproducibly for proton therapy in prostate cancer. 5/3/2013
L J Herrera, C M Fernandes, A M Mora, D Migotina, R Largo, A Guillen, A C Rosa Combination of heterogeneous EEG feature extraction methods and stacked sequential learning for sleep stage classification This work proposes a methodology for sleep stage classification based on two main approaches: the combination of features extracted from electroencephalogram (EEG) signal by different extraction methods, and the use of stacked sequential learning to incorporate predicted information from nearby slee... 5/1/2013
Shelly Seward, Assaad Semaan, Aamer M Qazi, Oksana V Gruzdyn, Sreedhar Chamala, Christopher C Bryant, Sanjeev Kumar, David Cameron, Seema Sethi, Rouba Ali-Fehmi, Robert Morris, David L Bouwman, Adnan R Munkarah, Donald W Weaver, Scott A Gruber, Ramesh B Batchu EZH2 blockade by RNA interference inhibits growth of ovarian cancer by facilitating re-expression of p21(waf1/cip1) and by inhibiting mutant p53 The enhancer of zeste homolog 2 (EZH2) methyltransferase is a transcriptional repressor. EZH2 is abnormally elevated in epithelial ovarian cancer (EOC). We demonstrated that EZH2 knockdown inhibited cell growth, activated apoptosis, and enhanced chemosensitivity. Further, silencing of EZH2 resulted ... 4/23/2013
Jana Milerová, Martin Anders, Tomáš Dvořák, Philipp G Sand, Stefanie Königer, Berthold Langguth The influence of psychological factors on tinnitus severity CONCLUSION: Psychological aspects as well as sociodemographic variables had a significant influence on both TQ scores. However, our results indicate, that these scales reflect emotional distress of tinnitus sufferers differently. This should be taken into consideration in the use of these scales as ... 4/23/2013
Amish P Shah, Patrick A Kupelian, Benjamin J Waghorn, Twyla R Willoughby, Justin M Rineer, Rafael R Mañon, Mark A Vollenweider, Sanford L Meeks Real-time tumor tracking in the lung using an electromagnetic tracking system CONCLUSIONS: Our initial experience with electromagnetic guidance within the lung demonstrates that transponder implantation and tracking is achievable though not clinically available. This research investigation proved that lung tumor motion exhibits large variations from fraction to fraction withi... 3/26/2013
Asaf Vivante, Michal Mark-Danieli, Miriam Davidovits, Orit Harari-Steinberg, Dorit Omer, Yehudit Gnatek, Roxana Cleper, Daniel Landau, Yael Kovalski, Irit Weissman, Israel Eisenstein, Michalle Soudack, Haike Reznik Wolf, Naomi Issler, Danny Lotan, Yair Anikster, Benjamin Dekel Renal hypodysplasia associates with a WNT4 variant that causes aberrant canonical WNT signaling Abnormal differentiation of the renal stem/progenitor pool into kidney tissue can lead to renal hypodysplasia (RHD), but the underlying causes of RHD are not well understood. In this multicenter study, we identified 20 Israeli pedigrees with isolated familial, nonsyndromic RHD and screened for mutat... 3/23/2013
Xiaoning Ding, Yuanshui Zheng, Omar Zeidan, Anthony Mascia, Wen Hsi, Yixiu Kang, Eric Ramirez, Niek Schreuder, Ben Harris A novel daily QA system for proton therapy We describe the design and use of a daily quality assurance (QA) system for proton therapy. The QA system is designed to check the overall readiness of proton therapy system consistently within certain reference tolerances by a home-made QA device (the QA device). The QA device is comprised of a com... 3/9/2013
Charles M Psoinos, Julie M Flahive, Joshua J Shaw, Youfu Li, Sing Chau Ng, Jennifer F Tseng, Heena P Santry Contemporary trends in necrotizing soft-tissue infections in the United States CONCLUSION: There were potentially important national trends in patient characteristics and treatment patterns for NSTI between 1998 and 2010. Importantly, though patient acuity worsened and complication rates increased, but LOS remained relatively stable and mortality decreased. Improvements in ear... 3/5/2013
Julie Pilitsis, Britney Atwater, Daniel Warden, Gina Deck, James Carroll, Jillian Smith, Sing Chau Ng, Jennifer Tseng Outcomes in octogenarians with subdural hematomas CONCLUSION: This study examines mortality rates in patients>80 with SDHs who are managed surgically and non-surgically using a large administrative database and institutional data. It provides preliminary insight into medical decision making which make affect mortality rates of the very elderly. 2/23/2013
Akash Nanda, Ming-Hui Chen, Brian J Moran, Michelle H Braccioforte, Anthony V D'Amico Cardiovascular comorbidity and mortality in men with prostate cancer treated with brachytherapy-based radiation with or without hormonal therapy CONCLUSIONS: In addition to age and unfavorable PC prognostic factors, select CAD risk factors and sequelae are associated with an increased risk of ACM in men treated for PC. These comorbidity prognostic factors predict time courses of mortality from competing causes, which may be factored into the... 1/22/2013
Elizaveta Ragulin-Coyne, Elan R Witkowski, Zeling Chau, Sing Chau Ng, Heena P Santry, Mark P Callery, Shimul A Shah, Jennifer F Tseng Is routine intraoperative cholangiogram necessary in the twenty-first century? A national view CONCLUSION: Routine IOC does not decrease the rate of bile duct injury, but is associated with significant added cost. Surgeons' routine use of IOC is correlated with increased rates of postsurgical procedures, and is associated with increased overall complications. These data suggest routine IOC ma... 1/8/2013
Matthew R Cooperberg, Naren R Ramakrishna, Steven B Duff, Kathleen E Hughes, Sara Sadownik, Joseph A Smith, Ashutosh K Tewari Primary treatments for clinically localised prostate cancer: a comprehensive lifetime cost-utility analysis CONCLUSIONS: Our analysis found small differences in outcomes and substantial differences in payer and patient costs across treatment alternatives. These findings may inform future policy discussions about strategies to improve efficiency of treatment selection for localised prostate cancer. 1/3/2013
Marie-Adele S Kress, Naren Ramakrishna, Solomon B Makgoeng, Keith R Unger, Arnold L Potosky Physician self-reported treatment of brain metastases according to patients' clinical and demographic factors and physician practice setting CONCLUSIONS: Poor prognostic factors, such as advanced age, poor performance status, or active extracranial disease, correspond with an increase in physicians' reported preference for using WBRT. When controlling for clinical factors, equipment access was independently associated with choice of SRS.... 11/10/2012
Brian T Kalish, Charles M Vollmer, Tara S Kent, William H Nealon, Jennifer F Tseng, Mark P Callery Quality assessment in pancreatic surgery: what might tomorrow require? CONCLUSIONS: Experts in pancreatic surgery have significant consensus on 12 proposed metrics of quality that they view as both highly important and aligned with more than one IOM healthcare quality domain. 11/7/2012
Stanley Ip, Issa J Dahabreh, Mei Chung, Winifred W Yu, Ethan M Balk, Ramon C Iovin, Paul Mathew, Tony Luongo, Tomas Dvorak, Joseph Lau An evidence review of active surveillance in men with localized prostate cancer CONCLUSIONS: More men are being diagnosed with early stage prostate cancer. Whether active monitoring with a curative intent is an appropriate option for these men remains unclear. A standard, universally agreed-upon definition of active surveillance that clearly distinguishes it from watchful waiti... 11/7/2012
John A Schinka, Diane C Robinson, Whitney L Mills, Lisa M Brown Cognitive change checklist: psychometric characteristics in community-dwelling older adults CONCLUSION: These findings provide support for the use of the checklist as a clinical tool to facilitate identification of cases of mild cognitive impairment and early dementia. 10/4/2012
Elan R Witkowski, Jillian K Smith, Jennifer F Tseng Outcomes following resection of pancreatic cancer Pancreatic cancer is an aggressive and highly lethal malignancy. Surgical resection is a modest tool, but it provides the only potential for curative therapy and often prolongs survival. This article reviews the progress made on both local and national levels towards an era of safer pancreatic surge... 9/20/2012
Akash Nanda, Ming-Hui Chen, Brian J Moran, Michelle H Braccioforte, Daniel Dosoretz, Sharon Salenius, Michael Katin, Rudi Ross, Anthony V D'Amico Neoadjuvant hormonal therapy use and the risk of death in men with prostate cancer treated with brachytherapy who have no or at least a single risk factor for coronary artery disease CONCLUSIONS: For men with no or at least a single risk factor for CAD, NHT use is associated with an increased risk of ACM in the setting of low-risk but not intermediate- or high-risk PCa. This effect is driven by the subgroup of men with at least a single risk factor for CAD. These results warrant... 9/18/2012
Aamer M Qazi, Oksana Gruzdyn, Assaad Semaan, Shelly Seward, Sreedhar Chamala, Vasu Dhulipala, Seema Sethi, Rouba Ali-Fehmi, Philip A Philip, David L Bouwman, Donald W Weaver, Scott A Gruber, Ramesh B Batchu Restoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101 CONCLUSION: These results suggest the potential therapeutic use of miR-101-enforced expression for inhibition of PDAC. 9/5/2012
Charles M Psoinos, Timothy A Emhoff, W Brian Sweeney, Jennifer F Tseng, Heena P Santry The dangers of being a "weekend warrior": a new call for injury prevention efforts CONCLUSION: Weekend warriors performing home roof and tree maintenance sustain serious injuries with a potential for a long-term disability at young ages. Injury prevention efforts should educate the public about the hazards of high-risk home maintenance, possibly encouraging Occupational Health and... 8/1/2012
Elizaveta Ragulin-Coyne, James E Carroll, Jillian K Smith, Elan R Witkowski, Sing Chau Ng, Shimul A Shah, Zheng Zhou, Jennifer F Tseng Perioperative mortality after pancreatectomy: a risk score to aid decision-making CONCLUSION: To maximize patient benefit, objective assessment of risk for major procedures is necessary. We developed a Surgical Outcomes Analysis and Research risk score predicting pancreatectomy mortality that combines national and institution-specific data to enhance decision-making. This type of... 7/7/2012
Christopher W Macomber, Joshua J Shaw, Heena Santry, Reza F Saidi, Nicolas Jabbour, Jennifer F Tseng, Adel Bozorgzadeh, Shimul A Shah Centre volume and resource consumption in liver transplantation CONCLUSIONS: This UHC-based cohort shows that increased centre volume results in improved long-term post-liver transplant outcomes and more efficient use of hospital resources thereby lowering the cost. A better understanding of these mechanisms can lead to informed decisions and optimization of the... 7/6/2012
Yuanshui Zheng, Yaxi Liu, Omar Zeidan, Andries Niek Schreuder, Sameer Keole Measurements of neutron dose equivalent for a proton therapy center using uniform scanning proton beams CONCLUSIONS: This study presents H/D as a function of various treatment parameters for uniform scanning proton beams. For similar treatment conditions, the H/D value per uncollimated beam size for uniform scanning beams was slightly lower than that from a passive scattering beam and higher than that... 7/5/2012
Roxana Cleper, Efrat Ben Shalom, Daniel Landau, Irith Weissman, Irit Krause, Osnat Konen, Ruth Rahamimov, Eytan Mor, Nathan Bar-Nathan, Yaakov Frishberg, Miriam Davidovits Post-transplantation lymphoproliferative disorder in pediatric kidney-transplant recipients - a national study PTLD is the most common malignancy in pediatric kidney-transplant recipients. We examined the prevalence, clinical features, and outcome of PTLD in Israel. Twelve (4.4%) of 272 pediatric (<19 yr) kidney-transplant recipients retrieved from a search of the NIKTR for 1991-2008 had acquired PTLD at a m... 6/20/2012
Tomas Dvorak, Markus M Fitzek, David E Wazer Utilization of proton therapy: evidence-based, market-driven, or something in-between? CONCLUSIONS: The degree of PT utilization would depend on the strictness of selection criteria, and would likely range from 6% to 25%, with concomitant cost increase from minimal to 40%. Ultimate adoption of PT in the United States may depend on individual facilities and payors performing similar an... 3/7/2012
Shelly Seward, Rouba Ali-Fehmi, Adnan R Munkarah, Assaad Semaan, Zaid R Al-Wahab, Mohamed A Elshaikh, Michele L Cote, Robert T Morris, Sudeshna Bandyopadhyay Outcomes of patients with uterine serous carcinoma using the revised FIGO staging system CONCLUSIONS: The streamlined 2009 FIGO criteria do not adequately delineate survival for USC in early-stage disease. The 1988 FIGO classification correctly identified 3 subgroups of stage I USC patients with significantly different survival that is lost with the elimination of the most favorable 198... 1/26/2012
Rafael A Madero-Visbal, Beatrice E Alvarado, Jimmie F Colon, Cheryl H Baker, Melissa S Wason, Beth Isley, Sudipta Seal, Chris M Lee, Soumen Das, Rafael Mañon Harnessing nanoparticles to improve toxicity after head and neck radiation This article reports the evaluation of cerium oxide (CeO(2)) nanoparticles' ability to decrease xerostomia and radiation-induced dermatitis in mice after head and neck radiation. Mice were irradiated using an IC160 x-ray system. Two cohorts were included: (A) No-radiation and (B) 30 Gy/6 fractions, ... 1/18/2012
Zhong Su, Olena Lopatiuk-Tirpak, Omar Zeidan, S I Sruprisan, Sanford L Meeks, Roelf Slopsema, Stella Flampouri, Zuofeng Li An experimental investigation into the effect of periodic motion on proton dosimetry using polymer gel dosimeters and a programmable motion platform Organ motion in proton therapy affects treatment dose distribution during both double-scattering (DS) and uniform-scanning (US) deliveries. We investigated the dosimetric impact of target motion using three-dimensional polymer gel dosimeters and a programmable motion platform. A simple one-beam trea... 1/14/2012
Julie G Pilitsis, Anthony Burrows, Mary Linton Peters, Julie Sargent, Sing Chau Ng, Jennifer F Tseng Changing practice patterns of deep brain stimulation in Parkinson's disease and essential tremor in the USA CONCLUSIONS: Patients who underwent DBS in the 2007 sample were older and had more comorbidities than those in the 2000 sample; in-hospital complications remained low. Understanding trends in DBS is helpful in assessing how the technology is adopted and what relationships should be further explored. 12/23/2011
Olena Lopatiuk-Tirpak, Zhong Su, Zuofeng Li, Wen Hsi, Sanford Meeks, Omar Zeidan Spatial correlation of proton irradiation-induced activity and dose in polymer gel phantoms for PET/CT delivery verification studies CONCLUSIONS: This work presents the first demonstration of simultaneous and accurate experimental measurement of three-dimensional distributions of dose and induced activity and lays the groundwork for further investigations using BANG3-Pro2 as a dosimetric phantom in PET/CT delivery verification st... 12/14/2011
Vikas Dudeja, Elizabeth B Habermann, Anasooya Abraham, Wei Zhong, Helen M Parsons, Jennifer F Tseng, Waddah B Al-Refaie Is there a role for surgery with adequate nodal evaluation alone in gastric adenocarcinoma? CONCLUSION: Surgery alone with adequate nodal evaluation may have a role in low-risk gastric cancer. To corroborate these findings, surgery with adequate lymphadenectomy alone (as treatment arm) deserves consideration in the design of gastric cancer trials to provide effective yet resource-conservin... 11/18/2011
Paul Rava, Tomas Dvorak, Robert J Markelewicz, Jessica R Hiatt, Edward S Sternick, Stephanie G MacAusland, Kathryn Huber, David E Wazer, Jaroslaw T Hepel A comparison of the biological effective dose of 50-kV electronic brachytherapy with (192)Ir high-dose-rate brachytherapy for vaginal cuff irradiation CONCLUSIONS: BED takes into account the higher RBE of low-energy photons generated with EBT and provides a more accurate estimate of the biological effect. When using EBT, physical dose may underestimate the biological effect on the vaginal mucosa and overestimate the benefit for the bladder and rec... 10/15/2011
María Del Mar Perez, Razvan Ghinea, Luis Javier Herrera, Ana Maria Ionescu, Héctor Pomares, Rosa Pulgar, Rade D Paravina Dental ceramics: a CIEDE2000 acceptability thresholds for lightness, chroma and hue differences CONCLUSIONS: There was a statistically significant difference amongst CIEDE2000 50:50% acceptability thresholds for lightness, chroma and hue differences for dental ceramics. The CIEDE2000(2:1:1) formula performed better than CIEDE2000(1:1:1). 10/12/2011
Elan R Witkowski, Jillian K Smith, Elizaveta Ragulin-Coyne, Sing-Chau Ng, Shimul A Shah, Jennifer F Tseng Is it worth looking? Abdominal imaging after pancreatic cancer resection: a national study CONCLUSION: Utilization of complex imaging after pancreatic cancer resection has increased substantially among Medicare beneficiaries, driven primarily by an increasing number of CT scans. Our study demonstrated no significant survival benefit among patients who received scans on a routine basis. 10/6/2011
Deepak K Ozhathil, YouFu Li, Jillian K Smith, Elan Witkowski, Elizaveta Ragulin Coyne, Karim Alavi, Jennifer F Tseng, Shimul A Shah Colectomy performance improvement within NSQIP 2005-2008 CONCLUSION: It appears that laparoscopic colectomies are growing in popularity over open colectomies, but the need for emergent open procedures remains unchanged. Across all colectomies, however, key postoperative and perioperative complications have improved over time. Participation in ACS NSQIP de... 8/30/2011
Ariel Troib, Daniel Landau, Jack F Youngren, Leonid Kachko, Ralph Rabkin, Yael Segev The effects of type 1 IGF receptor inhibition in a mouse model of diabetic kidney disease CONCLUSIONS: IGF1R inhibition by PQ401 exerted no significant effects on diabetic kidney disease parameters, arguing against a role for IGF-I in the pathogenesis of diabetic kidney disease. However, PQ401 affects normal kidneys, inducing renal hypertrophy as well as collagen and fat accumulation, wi... 8/26/2011
Daniel Landau, Jaclyn Biada, Yu Chen, Sumita Sood, Shoshanah Yakar, Derek Leroith, Yael Segev, Ralph Rabkin A marked deficiency in circulating and renal IGF-I peptide does not inhibit compensatory renal enlargement in uninephrectomized mice CONCLUSION: While a severe deficiency of circulating IGF-I impairs body growth, UNx induces a significant and proportional increase in renal mass in ID mice despite markedly decreased kidney IGF-I levels (>90% reduction) and no significant change in receptor phosphorylation. This all suggests that f... 8/25/2011
Agnieszka Vay, Sanjeev Kumar, Shelly Seward, Assaad Semaan, Charles A Schiffer, Adnan R Munkarah, Robert T Morris Therapy-related myeloid leukemia after treatment for epithelial ovarian carcinoma: an epidemiological analysis CONCLUSION: Development of t-AML is a rare but lethal event among EOC patients, and its incidence has decreased significantly since the use of platinum/taxane-based chemotherapy became the standard of care. 8/23/2011
Meng Wang, Fabian Morsbach, David Sander, Liliana Gheorghiu, Akash Nanda, Cyril Benes, Malte Kriegs, Mechthild Krause, Ekkehard Dikomey, Michael Baumann, Jochen Dahm-Daphi, Jeffrey Settleman, Henning Willers EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaks The mechanisms by which inhibition of the epidermal growth factor receptor (EGFR) sensitizes non-small cell lung cancer (NSCLC) cells to ionizing radiation remain poorly understood. We set out to characterize the radiosensitizing effects of the tyrosine kinase inhibitor erlotinib and the monoclonal ... 8/20/2011
Asaf Vivante, Danny Lotan, Naomi Pode-Shakked, Daniel Landau, Peter Svec, Sheela Nampoothiri, Ishwar Verma, Abdulsalam Abu-Libdeh, Detlef Bockenhauer, Benjamin Dekel, Yair Anikster Familial autosomal recessive renal tubular acidosis: importance of early diagnosis CONCLUSIONS: There is considerable delay in establishing a diagnosis of both types of RTA, supporting the need for earlier biochemical investigation. RTA due to ATP6V1B1 mutations is associated with mild progressive loss of kidney function. 8/19/2011
Vikas Dudeja, Greer Gay, Elizabeth B Habermann, Todd M Tuttle, Jennifer F Tseng, Barry W Feig, Waddah B Al-Refaie Do hospital attributes predict guideline-recommended gastric cancer care in the United States? CONCLUSIONS: The strong association between CoC hospital volume or type and guideline-recommended care diminishes after gastric cancer surgery. Variations in referral, insurance, and documentation patterns are potential explanations for these findings. These results highlight some limitations of usi... 8/13/2011
Assaad Semaan, Aamer M Qazi, Shelly Seward, Sreedhar Chamala, Christopher S Bryant, Sanjeev Kumar, Robert Morris, Christopher P Steffes, David L Bouwman, Adnan R Munkarah, Donald W Weaver, Scott A Gruber, Ramesh B Batchu MicroRNA-101 inhibits growth of epithelial ovarian cancer by relieving chromatin-mediated transcriptional repression of p21(waf¹/cip¹) CONCLUSIONS: MiR-101 re-expression appears to have antitumor effects, providing a better understanding of the role of miR-101 in EOC. 8/6/2011
Dganit Dinour, Nicola K Gray, Liat Ganon, Andrew J S Knox, Hanna Shalev, Ben-Ami Sela, Susan Campbell, Lindsay Sawyer, Xinhua Shu, Evgenia Valsamidou, Daniel Landau, Alan F Wright, Eliezer J Holtzman Two novel homozygous SLC2A9 mutations cause renal hypouricemia type 2 CONCLUSIONS: This is the second report of renal hypouricemia caused by homozygous GLUT9 mutations. Our findings confirm the pivotal role of GLUT9 in UA transport and highlight the similarities and differences between RHUC1 and RHUC2. 8/4/2011
Elisabet E Manasanch, Jillian K Smith, Andreea Bodnari, Jeannine McKinney, Catherine Gray, Theodore P McDade, Jennifer F Tseng Tumor registry versus physician medical record review: a direct comparison of patients with pancreatic neuroendocrine tumors CONCLUSION: Academic TR analysis indicates a substantial proportion of patients with pancreatic NETs are not identified when compared with MD review. Most instances of patients going unidentified are the result of registry time lag and case-finding methodologies; specifically, physicians may define ... 7/7/2011
David S Ziegler, Joanna Keating, Santosh Kesari, Eva M Fast, Leigh Zawel, Naren Ramakrishna, Jessica Barnes, Mark W Kieran, Sophie E M Veldhuijzen van Zanten, Andrew L Kung A small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivo We tested the use of the small-molecule Inhibitor of Apoptosis Protein (IAP) inhibitor LBW242 in combination with the standard-of-care therapies of irradiation and temozolomide for malignant gliomas. In vitro assays demonstrated that LBW242 enhanced the cytotoxic activity of radiotherapy, and clonog... 7/5/2011
Deepak K Ozhathil, Youfu Li, Jillian K Smith, Jennifer F Tseng, Reza F Saidi, Adel Bozorgzadeh, Shimul A Shah Effect of centre volume and high donor risk index on liver allograft survival CONCLUSION: While DRI remains an important aspect of allograft survival prediction models, liver transplantation at a HVC appears to result in improved allograft survival with high and very high risk DRI organs compared with LVC. 6/22/2011
Raveendhara R Bannuru, Tomas Dvorak, Ndidiamaka Obadan, Winifred W Yu, Kamal Patel, Mei Chung, Stanley Ip Comparative evaluation of radiation treatments for clinically localized prostate cancer: an updated systematic review CONCLUSION: A lack of high-quality comparative evidence precludes conclusions about the efficacy of radiation treatments compared with no treatments for localized prostate cancer. 6/8/2011
Yuanshui Zheng, Eric Ramirez, Anthony Mascia, Xiaoning Ding, Benny Okoth, Omar Zeidan, Wen Hsi, Ben Harris, Andries N Schreuder, Sameer Keole Commissioning of output factors for uniform scanning proton beams CONCLUSIONS: Comprehensive measurements at a large subset of available beam conditions are needed to commission output factors for proton therapy beams. The empirical modeling agrees well with the measured output factor data. This investigation indicates that it is possible to accurately predict out... 6/2/2011
Deepak K Ozhathil, You Fu Li, Jillian K Smith, Jennifer F Tseng, Reza F Saidi, Adel Bozorgzadeh, Shimul A Shah Impact of center volume on outcomes of increased-risk liver transplants The use of high-risk donor livers, which is reflective of the gross national shortage of organs available for transplantation, has gained momentum. Despite the demand, many marginal livers are discarded annually. We evaluated the impact of center volume on survival outcomes associated with liver tra... 5/24/2011
Haider Mahdi, Sanjeev Kumar, Shelly Seward, Assaad Semaan, Ramesh Batchu, David Lockhart, Hisham Tamimi, Adnan R Munkarah Prognostic impact of laterality in malignant ovarian germ cell tumors CONCLUSIONS: Compared with unilateral tumors, bilateral OGCT are more often associated with advanced-stage disease, high-risk histology, and poor survival. When other prognostic factors are accounted for, bilaterality was not an independent prognostic predictor of survival. 4/9/2011
Miguel Martin, Henri Roche, Tamas Pinter, John Crown, M John Kennedy, Louise Provencher, Frank Priou, Wolfgang Eiermann, Encarna Adrover, Istvan Lang, Manuel Ramos, Jean Latreille, Agnieszka Jagiełło-Gruszfeld, Tadeusz Pienkowski, Emilio Alba, Raymond Snyder, Sachin Almel, Janusz Rolski, Montserrat Munoz, Rebecca Moroose, Sara Hurvitz, Ana Baños, Henry Adewoye, Yong-Jiang Hei, Mary-Ann Lindsay, Matthieu Rupin, David Cabaribere, Yasmin Lemmerick, John R Mackey, TRIO 010 investigators Motesanib, or open-label bevacizumab, in combination with paclitaxel, as first-line treatment for HER2-negative locally recurrent or metastatic breast cancer: a phase 2, randomised, double-blind, placebo-controlled study BACKGROUND: Vascular endothelial growth factor (VEGF) has a crucial role in angiogenesis, and is a valid target in metastatic breast cancer. Motesanib is an investigational oral inhibitor of VEGF receptors. We aimed to determine whether treatment with motesanib plus paclitaxel is better than placebo... 3/25/2011
Andrew T Burr, YouFu Li, Jennifer F Tseng, Reza F Saidi, Adel Bozorgzadeh, Shimul A Shah Survival after liver transplantation using hepatitis C virus-positive donor allografts: case-controlled analysis of the UNOS database CONCLUSIONS: This is the first population-based analysis to show that after adjusting for donor and recipient characteristics there was no difference in graft or patient survival with the use of HCV+ donor liver allografts compared to HCV- donor liver allografts. 3/9/2011
Omar A Zeidan, Bhavin D Chauhan, William W Estabrook, Twyla R Willoughby, Rafael R Manon, Sanford L Meeks Image-guided bolus electron conformal therapy - a case study We report on our initial experience with daily image guidance for the treatment of a patient with a basal cell carcinoma of the nasal dorsum using bolus electron conformal therapy. We describe our approach to daily alignment using treatment machine-integrated megavoltage (MV) planar imaging in conju... 2/19/2011
Neal E Ready, Ritesh Rathore, Tirrell T Johnson, Ahmed Nadeem, Prakash Chougule, Charles Ruhl, Kathy Radie-Keane, Kathy Theall, Harold J Wanebo, Jennifer Marcello, Teresa Kennedy Weekly paclitaxel and carboplatin induction chemotherapy followed by concurrent chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck CONCLUSIONS: Therapy was active but patients must be carefully selected and monitored. Compared with the historical controls, dose dense and intense induction chemotherapy decreased distant failure rate without compromising the locoregional control. 2/5/2011
Stefan Glück, Terry Mamounas Improving outcomes in early-stage breast cancer Early-stage breast cancer is a prevalent malignancy that continues to cause a significant number of cancer-related deaths each year. Current evidence points to suboptimal care in patients with early-stage breast cancer, especially with regard to physician use of guideline-recommended care. Such appr... 2/3/2011
Deviney Chaponis, Jessica W Barnes, Jamie L Dellagatta, Santosh Kesari, Eva Fast, Claire Sauvageot, Dipak Panagrahy, Emily R Greene, Naren Ramakrishna, Patrick Y Wen, Andrew L Kung, Charles Stiles, Mark W Kieran Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas Malignant gliomas are highly lethal tumors resistant to current therapies. The standard treatment modality for these tumors, surgical resection followed by radiation therapy and concurrent temozolomide, has demonstrated activity, but development of resistance and disease progression is common. Altho... 1/20/2011
Haider Mahdi, Melissa Thrall, Sanjeev Kumar, Rabbie Hanna, Shelly Seward, David Lockhart, Robert T Morris, Ron Swensen, Adnan R Munkarah The prognostic impact of the ratio of positive lymph nodes on survival of epithelial ovarian cancer patients CONCLUSIONS: The impact of increasing LNR was strongly related to survival, especially in patients with no macroscopic peritoneal disease. Stratification of this subpopulation of node positive EOC based on nodal burden provides a significant prognostic value that may be considered in future staging ... 1/18/2011
Pius Maliakal, Maen Abdelrahim, Umesh T Sankpal, Cima Maliakal, Cheryl H Baker, Stephen Safe, Luis J Herrera, Ala Abudayyeh, Sumanth Kaja, Riyaz Basha Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats The primary objective of this study is to identify small molecules that target critical transcription factors for potential application in the chemoprevention of esophageal cancer. Specificity proteins (Sp) play a critical role in the growth and metastasis of several malignancies including esophagea... 1/4/2011
Assaad Semaan, Adnan R Munkarah, Haitham Arabi, Sudeshna Bandyopadhyay, Shelly Seward, Sanjeev Kumar, Aamer Qazi, Yasser Hussein, Robert T Morris, Rouba Ali-Fehmi Expression of GLUT-1 in epithelial ovarian carcinoma: correlation with tumor cell proliferation, angiogenesis, survival and ability to predict optimal cytoreduction CONCLUSION: Expression of GLUT-1 correlates with tumor proliferation and microvessel density in epithelial ovarian carcinoma. In addition, patients with rapidly proliferating advanced stage tumors overexpressing GLUT-1 have a lesser chance for optimal cytoreduction. 12/21/2010
Andrew T Burr, Nicholas G Csikesz, Earl Gonzales, Jennifer F Tseng, Reza F Saidi, Adel Bozorgzadeh, Shimul A Shah Comparison of right lobe donor hepatectomy with elective right hepatectomy for other causes in New York CONCLUSIONS: This study represents one of the first unsolicited regional analyses of donor morbidity and resource utilization for RLDH and further emphasizes the need and utility of a live donor registry. 11/30/2010
Anand Singla, James L Hart, Youfu Li, Jennifer F Tseng, Shimul A Shah Hospitalization for complications of cirrhosis: does volume matter? CONCLUSION: Despite increased LOS and hospital cost, a mortality benefit exists at HV centers. Future studies are necessary to determine other processes of care that may exist at HV centers that may account for this survival benefit. 11/26/2010
Maya Feldshtein, Suliman Elkrinawi, Baruch Yerushalmi, Barak Marcus, Daniela Vullo, Hila Romi, Rivka Ofir, Daniel Landau, Sara Sivan, Claudiu T Supuran, Ohad S Birk Hyperchlorhidrosis caused by homozygous mutation in CA12, encoding carbonic anhydrase XII Excessive chloride secretion in sweat (hyperchlorhidrosis), leading to a positive sweat test, is most commonly indicative of cystic fibrosis yet is found also in conjunction with various metabolic, endocrine, and dermatological disorders. There is conflicting evidence regarding the existence of auto... 11/2/2010
Shimul A Shah, Jillian K Smith, Youfu Li, Sing Chau Ng, James E Carroll, Jennifer F Tseng Underutilization of therapy for hepatocellular carcinoma in the medicare population CONCLUSIONS: In the Medicare population, HCC patients who received therapy experienced a substantial survival advantage over their nonoperative peers (NoTx). Despite evidence that many patients had favorable biological characteristics, <30% of patients diagnosed with HCC received any treatment. 10/15/2010
Karim Alavi, Paul R Sturrock, W B Sweeney, Justin A Maykel, J A Cervera-Servin, Jennifer Tseng, E F Cook A simple risk score for predicting surgical site infections in inflammatory bowel disease CONCLUSIONS: Patients with inflammatory bowel disease are at high risk for surgical site infections. Preoperative factors including weight loss, smoking, emergent surgery and an ASA score >2 are strong predictors of surgical site infections. Operative time and wound class are important intraoperativ... 10/14/2010
Danny Landau, Nicholas Avgeropoulos, Joe Ma Cerebral amyloidoma mimicking intracranial tumor: a case report CONCLUSION: After discovery of the true etiology of his brain abnormality, it was determined that our patient had a more benign disease than was initially feared. Cases such as this demonstrate why consideration of this disorder is important. 9/22/2010
James Edward Carroll, Jillian K Smith, Jessica P Simons, Melissa M Murphy, Sing Chau Ng, Shimul A Shah, Zheng Zhou, Jennifer F Tseng Redefining mortality after pancreatic cancer resection CONCLUSIONS: In-hospital and 30-day mortality after resection for cancer are similar nationally; thus, comparing mortality utilizing these measures is acceptable. After a 60-day post-resection window of increased mortality, mortality risk then continues at a constant rate over 2 years, suggesting th... 9/17/2010
Bharath Nath, YouFu Li, James E Carroll, Gyongyi Szabo, Jennifer F Tseng, Shimul A Shah Alcohol exposure as a risk factor for adverse outcomes in elective surgery CONCLUSIONS: Active alcohol consumption is a significant determinant of adverse outcomes in elective surgery; patients with ETOH use who are scheduled to undergo elective surgery should be appropriately educated and counseled. 9/15/2010
Jillian K Smith, Joshua S Hill, Sing Chau Ng, Theodore P McDade, Shimul A Shah, Jennifer F Tseng Potential benefit of resection for stage IV gastric cancer: a national survey CONCLUSIONS: Patients with stage IV gastric cancer who undergo resection, a highly selected population, have significantly greater survival than unresected patients, including those who were recommended for, but did not receive, resection. Stage IV gastric cancer patients who are reasonable operativ... 9/10/2010
Beth Colombo, Anand Singla, YouFu Li, Jennifer F Tseng, Reza F Saidi, Adel Bozorgzadeh, Shimul A Shah Current trends and short-term outcomes of live donor nephrectomy: a population-based analysis of the nationwide inpatient sample CONCLUSIONS: In the United Stares, LDNs are performed safely with a low short-term complication rate. Despite the use of laparoscopy and the increased need of donor organs, the rate of LDN in kidney transplantation has not increased proportionally. 9/3/2010
Sara A Hurvitz, Heather J Allen, Rebecca L Moroose, David Chan, Christopher Hagenstad, Steven H Applebaum, Giribala Patel, Eddie H Hu, Nancy Ryba, Lii-Shin Lin, Hejing Wang, John Glaspy, Dennis J Slamon, Fairooz Kabbinavar A phase II trial of docetaxel with bevacizumab as first-line therapy for HER2-negative metastatic breast cancer (TORI B01) CONCLUSION: Docetaxel/bevacizumab was generally well tolerated with manageable toxicity and promising efficacy results. 8/14/2010
Stanley Ip, Tomas Dvorak, Winifred W Yu, Kamal Patel, Ndidiamaka Obadan, Mei Chung, Raveendhara R Bannuru, Joseph Lau Comparative Evaluation of Radiation Treatments for Clinically Localized Prostate Cancer: an Update [Internet] The Coverage and Analysis Group at the Centers for Medicare and Medicaid Services (CMS) requested this report from The Technology Assessment Program (TAP) at the Agency for Healthcare Research and Quality (AHRQ). AHRQ assigned this report to the following Evidence-based Practice Center: Tufts EPC (C... 8/13/2010
Daniel Landau, Hanna Shalev Childhood genetic renal diseases in southern Israel Genetic kidney diseases (GKDs) are an important and well-known entity in pediatric nephrology. Advances in genetic and molecular approaches in the last 15 years have enabled elucidation of the underlying molecular defects in many of these disorders. Herein, the authors summarize the progress that ha... 8/6/2010
Razvan Ghinea, María M Pérez, Luis J Herrera, María José Rivas, Ana Yebra, Rade D Paravina Color difference thresholds in dental ceramics CONCLUSIONS: The CIEDE2000 color difference formula provided a better fit than CIELAB formula in the evaluation of color difference thresholds of dental ceramics. There was a statistically significant difference between perceptibility and acceptability thresholds for dental ceramics. The TSK Fuzzy A... 7/31/2010
Evan S Glazer, Jennifer F Tseng, Waddah Al-Refaie, Carmen C Solorzano, Ping Liu, Katherine A Willborn, Eddie K Abdalla, Jean-Nicolas Vauthey, Steven A Curley Long-term survival after surgical management of neuroendocrine hepatic metastases BACKGROUND: Surgical cytoreduction and endocrine blockade are important options for care for neuroendocrine liver metastases. We investigated the long-term survival of patients surgically treated for hepatic neuroendocrine metastases. 7/29/2010
Tomas Dvorak, David E Wazer Evaluation of potential proton therapy utilization in a market-based environment CONCLUSIONS: Using existing utilization patterns of highly conformal photon therapy as a proxy, approximately one-third of patients irradiated annually at the authors' institution could be treated with proton therapy, with an incremental cost of 20% across the entire treated patient population. 7/16/2010
Melissa M Murphy, Sing-Chau Ng, Jessica P Simons, Nicholas G Csikesz, Shimul A Shah, Jennifer F Tseng Predictors of major complications after laparoscopic cholecystectomy: surgeon, hospital, or patient? CONCLUSIONS: Major in-hospital complications after LC are associated with individual patient characteristics rather than surgeon or hospital operative volumes. These results suggest regionalization of general surgical procedures might be unnecessary. Rather, careful patient selection and preoperativ... 7/9/2010
Ruth Schreiber, Marie-Claire Gubler, Olivier Gribouval, Hanna Shalev, Daniel Landau Inherited renal tubular dysgenesis may not be universally fatal Inherited renal tubular dysgenesis (RTD) is caused by mutations in the genes encoding components of the renin-angiotensin cascade: angiotensinogen, renin, angiotensin-converting enzyme (ACE), and angiotensin ΙΙ receptor type 1. It is characterized by oligohydramnios, prematurity, hypotension, hypo... 7/8/2010
Rajul Kothari, Carl Morrison, Debra Richardson, Shelly Seward, David O'Malley, Larry Copeland, Jeffrey Fowler, David E Cohn The prognostic significance of the triple negative phenotype in endometrial cancer CONCLUSIONS: The TNP is associated with advanced stage, high grade, and high risk histology, as well as poor survival. Continued investigation of the exploitation of this phenotype with targeted therapies is necessary. 7/8/2010
Jillian K Smith, Sing Chau Ng, Joshua S Hill, Jessica P Simons, Edward J Arous, Shimul A Shah, Jennifer F Tseng, Theodore P McDade Complications after pancreatectomy for neuroendocrine tumors: a national study CONCLUSIONS: While in-hospital mortality rates are low for surgical resection of PNETs, there is a considerable overall postoperative complication rate associated with these procedures. Careful patient and surgery selection may be the key to a surgical treatment approach for PNETs that may optimize ... 7/6/2010
May Piperdi, Theodore P McDade, Joon K Shim, Bilal Piperdi, Sidney P Kadish, Mary E Sullivan, Giles F Whalen, Jennifer F Tseng A neoadjuvant strategy for pancreatic adenocarcinoma increases the likelihood of receiving all components of care: lessons from a single-institution database CONCLUSION: After resection, a substantial proportion of patients do not receive adjuvant therapy, and have worse survival. In this study, neoadjuvant treatment increased both the proportion of patients receiving all components of recommended therapy and the R0 resection rate. 7/2/2010
Theodore P McDade, Joshua S Hill, Jessica P Simons, Bilal Piperdi, Sing Chau Ng, Zheng Zhou, Sidney P Kadish, Thomas J Fitzgerald, Jennifer F Tseng A national propensity-adjusted analysis of adjuvant radiotherapy in the treatment of resected pancreatic adenocarcinoma CONCLUSIONS: Adjuvant RT for resected pancreatic adenocarcinoma was associated with a significant survival advantage in a large national database, even after using propensity score methods to adjust for differences between treatment groups. The authors concluded that adjuvant RT should be considered... 6/22/2010
George C Bobustuc, Cheryl H Baker, Arati Limaye, Wayne D Jenkins, Gary Pearl, Nicholas G Avgeropoulos, Santhi D Konduri Levetiracetam enhances p53-mediated MGMT inhibition and sensitizes glioblastoma cells to temozolomide Antiepileptic drugs (AEDs) are frequently used to treat seizures in glioma patients. AEDs may have an unrecognized impact in modulating O(6)-methylguanine-DNA methyltransferase (MGMT), a DNA repair protein that has an important role in tumor cell resistance to alkylating agents. We report that levet... 6/8/2010
Abdullah O Kandil, Tomas Dvorak, John Mignano, Julian K Wu, Jay-Jiguang Zhu Multifocal Stevens-Johnson syndrome after concurrent phenytoin and cranial and thoracic radiation treatment, a case report A 46 year old male patient with metastatic prostate cancer developed Stevens-Johnson syndrome (SJS), initially in three well-demarcated areas on his scalp, chest and back, corresponding to ports of radiation therapy while on phenytoin. The rash spread from these locations and became more generalized... 6/8/2010
James E Carroll, Zachary M Hurwitz, Jessica P Simons, James T McPhee, Sing Chau Ng, Shimul A Shah, Waddah B Al-Refaie, Jennifer F Tseng In-hospital mortality after resection of biliary tract cancer in the United States CONCLUSION: Increased in-hospital mortality for patients undergoing biliary tract cancer resection corresponded to age, comorbidity, hospital volume, and emergent admission. Further study is warranted to utilize these observations in promoting early detection, diagnosis, and elective resection. 5/25/2010
John Hayward, Sergio A Alvarez, Carolina Ruiz, Mary Sullivan, Jennifer Tseng, Giles Whalen Machine learning of clinical performance in a pancreatic cancer database CONCLUSION: Machine learning provides techniques for improved prediction of clinical performance. These techniques therefore merit consideration as valuable alternatives to traditional multivariate regression techniques in clinical medical studies. 5/21/2010
Jason T Wiseman, Maia N Sharuk, Anand Singla, Mitchell Cahan, Demetrius E M Litwin, Jennifer F Tseng, Shimul A Shah Surgical management of acute cholecystitis at a tertiary care center in the modern era CONCLUSIONS: Based on 5-year results from a tertiary care center, LC was performed with a low conversion rate to open surgery and was associated with decreased morbidity and mortality compared with other surgical modalities to treat AC. Our data confirm the benefits and widespread use of LC in the m... 5/19/2010
Zheng Zhou, Theodore P McDade, Jessica P Simons, Sing Chau Ng, Laura A Lambert, Giles F Whalen, Shimul A Shah, Jennifer F Tseng Surgery and radiotherapy for retroperitoneal and abdominal sarcoma: both necessary and sufficient CONCLUSIONS: In a national cohort of retroperitoneal and abdominal sarcomas, surgical resection was associated with significant survival benefits for AJCC disease stages I to III. Radiotherapy provided additional benefit for patients with stage I disease. Resection should be offered to reasonable su... 5/19/2010
Arnon Broides, Michal S Maimon, Daniel Landau, Joseph Press, Matitiahu Lifshitz Multiple hymenoptera stings in children: clinical and laboratory manifestations Multiple hymenoptera stings are a cause of rhabdomyolysis, elevated liver enzymes, clotting abnormalities, kidney injury, and even death. However, the progression of the clinical and laboratory findings has been described mainly in sporadic case reports. We report the clinical and laboratory manifes... 5/13/2010
Sajeve S Thomas, Erin M Dunbar Modern multidisciplinary management of brain metastases Ideal management of brain metastases (BMs) requires simultaneous control of the existing brain metastasis (local brain control), prevention of future BMs (distant brain control), and control of the systemic cancer (systemic control). Available tools include whole brain radiation therapy (WBRT), surg... 4/29/2010
Melissa M Murphy, Elan R Witkowski, Sing Chau Ng, Theodore P McDade, Joshua S Hill, Anne C Larkin, Giles F Whalen, Demetrius E Litwin, Jennifer F Tseng Trends in adrenalectomy: a recent national review CONCLUSION: Adrenalectomy is increasingly performed nationwide for both benign and malignant indications. In this study, whereas perioperative mortality remained low, major postoperative complications increased significantly. 3/26/2010
Christopher S Bryant, Sanjeev Kumar, Sreedhar Chamala, Jay Shah, Jagannath Pal, Mahdi Haider, Shelly Seward, Aamer M Qazi, Robert Morris, Assaad Semaan, Masood A Shammas, Christopher Steffes, Ravindra B Potti, Madhu Prasad, Donald W Weaver, Ramesh B Batchu Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells CONCLUSIONS: SFN induces growth arrest and apoptosis in EOC cells. Inhibition of retinoblastoma (RB) phosphorylation and reduction in levels of free E2F-1 appear to play an important role in EOC growth arrest. 3/4/2010
Joshua S Hill, Zheng Zhou, Jessica P Simons, Sing Chau Ng, Theodore P McDade, Giles F Whalen, Jennifer F Tseng A simple risk score to predict in-hospital mortality after pancreatic resection for cancer CONCLUSIONS: An integer-based risk score can be used to accurately predict in-hospital mortality after pancreatectomy and may be useful for preoperative risk stratification and patient counseling. 2/16/2010
Jessica P Simons, Sing Chau Ng, Joshua S Hill, Shimul A Shah, Zheng Zhou, Jennifer F Tseng In-hospital mortality from liver resection for hepatocellular carcinoma: a simple risk score CONCLUSIONS: : The current results indicated that an integer-based risk score can be used to predict in-hospital mortality after surgery for hepatocellular carcinoma, and it may be useful for preoperative risk stratification and patient counseling. Cancer 2010. (c) 2010 American Cancer Society. 2/10/2010
Jessica P Simons, Sing Chau Ng, Theodore P McDade, Zheng Zhou, Craig C Earle, Jennifer F Tseng Progress for resectable pancreatic [corrected] cancer?: a population-based assessment of US practices CONCLUSIONS: : Adherence to guideline-directed care isimproving in the United States; however, the pace is slow, and overall survival has yet to be impacted significantly. Both increased use of adjuvant therapy and the development of more promising systemic treatments are necessary to improve surviv... 2/10/2010
Naren Ramakrishna, Florin Rosca, Scott Friesen, Evrim Tezcanli, Piotr Zygmanszki, Fred Hacker A clinical comparison of patient setup and intra-fraction motion using frame-based radiosurgery versus a frameless image-guided radiosurgery system for intracranial lesions CONCLUSIONS: The overall system accuracy is similar to that reported for invasive frame-based SRS. The intra-fraction motion was larger with mask-immobilization, but remains within a range appropriate for stereotactic treatment. These results support clinical implementation of frameless radiosurgery... 2/2/2010
Luis J Herrera, Rosa Pulgar, Janiley Santana, Juan C Cardona, Alberto Guillén, Ignacio Rojas, María del Mar Pérez Prediction of color change after tooth bleaching using fuzzy logic for Vita Classical shades identification Tooth bleaching is becoming increasingly popular among patients and dentists since it is a relatively noninvasive approach for whitening and lightening teeth. Instruments and visual assessment with respect to commercial shade guides are currently used to evaluate tooth color. However, the associatio... 1/22/2010
Stuart J Conway, James Gardiner, Simon J A Grove, Melloney K Johns, Ze-Yi Lim, Gavin F Painter, Diane E J E Robinson, Christine Schieber, Jan W Thuring, Leon S-M Wong, Meng-Xin Yin, Antony W Burgess, Bruno Catimel, Phillip T Hawkins, Nicholas T Ktistakis, Leonard R Stephens, Andrew B Holmes Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes The synthesis of the complete family of phosphatidylinositol phosphate analogues (PIPs) from five key core intermediates A-E is described. These core compounds were obtained from myo-inositol orthoformate 1 via regioselective DIBAL-H and trimethylaluminium-mediated cleavages and a resolution-protect... 12/22/2009
Steven D Bull, Matthew G Davidson, Andrew L Johnson, Mary F Mahon, Diane E J E Robinson An air stable moisture resistant titanium triflate complex as a Lewis acid catalyst for C-C bond forming reactions An air and moisture stable C(3)-symmetric titanium(IV) triflate, supported by a tripodal amine-(tris-phenolate) ligand, has been synthesized and characterized by X-ray crystallography and shown to be a good Lewis acid catalyst for a range of aza-Diels-Alder, Diels-Alder, syn aldol, allylation, and a... 12/17/2009
Melissa M Murphy, Jennifer F Tseng, Shimul A Shah Disparities in cancer care: an operative perspective CONCLUSION: Disparities in cancer care and outcomes clearly exist for many poorly understood reasons. After a diagnosis of cancer, barriers to care may develop at multiple points along the course of the patient's disease. 12/8/2009
Waddah B Al-Refaie, Greer Gay, Beth A Virnig, Jennifer F Tseng, Andrew Stewart, Selwyn M Vickers, Todd M Tuttle, Barry W Feig Variations in gastric cancer care: a trend beyond racial disparities CONCLUSIONS: There were significant variations in treatment for gastric cancer among ethnic groups in the United States. It was noteworthy that, although nonwhite race was associated with improved surgical care, gastric cancer care remained suboptimal overall. Cancer programs need to identify proced... 12/2/2009
Philip Axe, Steven D Bull, Matthew G Davidson, Matthew D Jones, Diane E J E Robinson, William L Mitchell, John E Warren An enantiopure pseudo-C3-symmetric titanium triflate with propeller-like chirality as a catalyst for asymmetric sulfoxidation reactions A chiral pseudo-C(3)-symmetric titanium triflate that employs the point chirality of a single stereogenic centre to control the propeller chirality of its aryl rings has been used to catalyse an asymmetric sulfoxidation reaction. 11/19/2009
Nicholas G Csikesz, Anand Singla, Melissa M Murphy, Jennifer F Tseng, Shimul A Shah Surgeon volume metrics in laparoscopic cholecystectomy CONCLUSIONS: Increasing surgical volume remains associated with improved outcomes after surgery during emergent/urgent admission for AC with fewer open conversions and prolonged LOS. Our results suggest that referral to HV surgeons has improved outcomes after LC for AC. 11/14/2009
Steven W Hwang, Mohab M Abozed, Andrew Hale, Rebecca L Eisenberg, Tomas Dvorak, Kevin Yao, Rolf Pfannl, John Mignano, Jay-Jiguang Zhu, Lori Lyn Price, Gary M Strauss, Julian K Wu Adjuvant Gamma Knife radiosurgery following surgical resection of brain metastases: a 9-year retrospective cohort study Given the potential morbidity of whole brain radiation therapy (WBRT), there has been an increasing trend to defer WBRT and deliver Gamma Knife stereotactic radiosurgery (GKS) to cerebral metastatic lesions. We analyzed our experience delivering GKS to the tumor cavity following surgical resection o... 11/12/2009
Jessica P Simons, Joshua S Hill, Sing Chau Ng, Shimul A Shah, Zheng Zhou, Giles F Whalen, Jennifer F Tseng Perioperative mortality for management of hepatic neoplasm: a simple risk score CONCLUSIONS: An integer-based risk score can be used to predict in-hospital mortality after hepatic procedure for neoplasm, and may be useful for preoperative risk stratification and patient counseling. 10/27/2009
Jimmie Colon, Md Riyaz Basha, Rafael Madero-Visbal, Santhi Konduri, Cheryl H Baker, Luis J Herrera, Stephen Safe, David Sheikh-Hamad, Ala Abudayyeh, Beatrice Alvarado, Maen Abdelrahim Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice The nonsteroidal anti-inflammatory drug (NSAID), tolfenamic acid (TA) is emerging as a new anti-cancer agent. TA induces the degradation of specific Specificity protein (Sp) transcription factors, Sp1, Sp3 and Sp4 which are associated with tumor growth and metastasis. In this study we have evaluated... 10/24/2009
Melissa M Murphy, William J Knaus, Sing Chau Ng, Joshua S Hill, James T McPhee, Shimul A Shah, Jennifer F Tseng Total pancreatectomy: a national study BACKGROUND: Total pancreatectomy (TP) is performed for various indications. Historically, morbidity and mortality have been high. Recent series reporting improved peri-operative mortality have renewed interest in TP. We performed a national review of TP including indication, patient/hospital charact... 10/10/2009
Joshua S Hill, James T McPhee, Giles F Whalen, Mary E Sullivan, Andrew L Warshaw, Jennifer F Tseng In-hospital mortality after pancreatic resection for chronic pancreatitis: population-based estimates from the nationwide inpatient sample CONCLUSIONS: Pancreatectomies for chronic pancreatitis have lower in-hospital mortality than those performed for malignancy and similar rates as resection for benign tumors. Pancreatic resection, which can improve quality of life in chronic pancreatitis patients, can be performed with moderate morta... 10/6/2009
Anand Singla, Nicholas G Csikesz, Jessica P Simons, You Fu Li, Sing Chau Ng, Jennifer F Tseng, Shimul A Shah National hospital volume in acute pancreatitis: analysis of the Nationwide Inpatient Sample 1998-2006 CONCLUSIONS: Rates of admissions for acute pancreatitis in the USA are increasing. High annual hospital volume of acute pancreatitis cases confers a shorter LOS, lower adjusted mortality and a lower likelihood of pancreatic procedure for patients admitted with acute pancreatitis. Although HV hospita... 9/22/2009
Jessica P Simons, Sing Chau Ng, Shimul A Shah, Theodore P McDade, Giles F Whalen, Jennifer F Tseng Malignant intraductal papillary mucinous neoplasm: are we doing the right thing? CONCLUSIONS: In this population-based cohort, detection of malignant IPMNs is decreasing, with an increasing proportion of patients diagnosed at local stages and undergoing resection. Increased awareness of IPMN may be contributing to earlier detection, which might include benign/premalignant lesion... 9/22/2009
Nicholas G Csikesz, Anand Singla, Jessica P Simons, Jennifer F Tseng, Shimul A Shah The impact of socioeconomic status on presentation and treatment of diverticular disease CONCLUSION: Patients of low SES who are admitted with diverticular disease have an increased likelihood to present emergently, have worse disease on admission, and are less likely to receive surgery. 9/18/2009
Teruhiko Terasawa, Tomas Dvorak, Stanley Ip, Gowri Raman, Joseph Lau, Thomas A Trikalinos Systematic review: charged-particle radiation therapy for cancer CONCLUSION: Evidence on the comparative effectiveness and safety of charged-particle radiation therapy in cancer is needed to assess the benefits, risks, and costs of treatment alternatives. 9/17/2009
Akash Nanda, Ming-Hui Chen, Brian J Moran, Michelle H Braccioforte, Daniel Dosoretz, Sharon Salenius, Michael Katin, Rudi Ross, Anthony V D'Amico Predictors of prostate cancer-specific mortality in elderly men with intermediate-risk prostate cancer treated with brachytherapy with or without external beam radiation therapy CONCLUSIONS: In elderly men with intermediate-risk prostate cancer, CVD status is a negative predictor of PCSM and affects the prognostic capacity of pretreatment PSA level. These observations support the potential utility of prerandomization stratification by comorbidity to more accurately assess p... 9/12/2009
Anand Singla, Jessica Simons, YouFu Li, Nicholas G Csikesz, Sing Chau Ng, Jennifer F Tseng, Shimul A Shah Admission volume determines outcome for patients with acute pancreatitis CONCLUSIONS: The rates of admissions for AP in the United States are increasing. At hospitals that admit the most patients with AP, patients had a shorter length of stay, lower hospital charges, and lower mortality rates than controls in this matched analysis. 9/8/2009
Melloney K Johns, Meng-Xin Yin, Stuart J Conway, Diane E J E Robinson, Leon S-M Wong, Rebecca Bamert, Richard E H Wettenhall, Andrew B Holmes Synthesis and biological evaluation of a novel cardiolipin affinity matrix Cardiolipin (1) is a dimeric phospholipid found in the mitochondrial membranes of both plants and animals. In order to understand better its role, we report the preparation of an immobilised analogue (2) using phosphoramidite chemistry; the probe has been used successfully to bind a recombinant prot... 8/27/2009
Akash Nanda, Ming-Hui Chen, Michelle H Braccioforte, Brian J Moran, Anthony V D'Amico Hormonal therapy use for prostate cancer and mortality in men with coronary artery disease-induced congestive heart failure or myocardial infarction CONCLUSION: Neoadjuvant HT use is significantly associated with an increased risk of all-cause mortality among men with a history of CAD-induced CHF or MI but not among men with no comorbidity or a single CAD risk factor. 8/27/2009
Shelly M Seward, Debra L Richardson, Marino E Leon, Weiqiang Zhao, David E Cohn, Charles L Hitchcock Metastatic squamous cell carcinoma of the vulva to the lung confirmed with allelotyping A squamous-cell carcinoma (SCC) of the lung can be indistinguishable from metastatic SCC of gynecologic origin using common histopathologic techniques; however, establishing tumor origin can be clinically relevant. A patient with a Bartholin gland SCC was found to also have a pulmonary SCC, concerni... 8/22/2009
Anand Singla, Jessica P Simons, James E Carroll, Youfu Li, Sing Chau Ng, Jennifer F Tseng, Shimul A Shah Hospital volume as a surrogate for laparoscopically assisted colectomy CONCLUSIONS: Socioeconomic differences appear to exist between high- and low-volume hospitals in the use of laparoscopy. High hospital volume is associated with an increased likelihood that colectomy will be performed with laparoscopy. 8/19/2009
Melissa M Murphy, Shimul A Shah, Jessica P Simons, Nicholas G Csikesz, Theodore P McDade, Andreea Bodnari, Sing-Chau Ng, Zheng Zhou, Jennifer F Tseng Predicting major complications after laparoscopic cholecystectomy: a simple risk score CONCLUSION: An integer-based risk score can be used to predict complications following LC and may assist in preoperative risk stratification and patient counseling. 8/13/2009
Melissa M Murphy, Jessica P Simons, Sing Chau Ng, Theodore P McDade, Jillian K Smith, Shimul A Shah, Zheng Zhou, Craig C Earle, Jennifer F Tseng Racial differences in cancer specialist consultation, treatment, and outcomes for locoregional pancreatic adenocarcinoma CONCLUSIONS: Racial disparities exist in pancreatic cancer specialist consultation and subsequent therapy use. Because receipt of care is fundamental to reducing outcome discrepancies, these barriers serve as discrete intervention points to ensure all locoregional pancreatic adenocarcinoma patients ... 8/12/2009
Anand Singla, Youfu Li, Sing Chau Ng, Nicholas G Csikesz, Jennifer F Tseng, Shimul A Shah Is the growth in laparoscopic surgery reproducible with more complex procedures? CONCLUSION: Despite the significant benefits of complex LAP procedures as measured by LOS and in-hospital mortality, the growth of these operations has been slow unlike the rapid acceptance of LAP cholecystectomy. Future studies to identify the possible causes of this slow growth should consider cur... 7/25/2009
Harold Salant, Daniel Yasur Landau, Gad Baneth A cross-sectional survey of Toxoplasma gondii antibodies in Israeli pigeons A cross-sectional prevalence study was performed for anti-Toxoplasma gondii antibodies using the Modified Agglutination Test (MAT) in 495 wild pigeons (Columba livia) captured from various locations in Israel. Seropositivity was found in 20/495 (4%) of the birds. Pigeon samples in regions of semi-ar... 7/22/2009
Jessica P Simons, Sing Chau Ng, Joshua S Hill, Shimul A Shah, Andreea Bodnari, Zheng Zhou, Jennifer F Tseng In-hospital mortality for liver resection for metastases: a simple risk score CONCLUSION: An integer-based risk score can be used to predict in-hospital mortality after hepatic procedure for metastases, and may be useful for preoperative patient counseling. 7/7/2009
Akash Nanda, Ming-Hui Chen, Brian J Moran, Michelle H Braccioforte, Daniel Dosoretz, Sharon Salenius, Michael Katin, Rudi Ross, Anthony V D'Amico Total androgen blockade versus a luteinizing hormone-releasing hormone agonist alone in men with high-risk prostate cancer treated with radiotherapy CONCLUSIONS: In men with localized but high-risk prostate cancer treated with external beam radiotherapy and brachytherapy, short-course AST with an LHRH agonist plus an antiandrogen is associated with a decreased risk of PCSM when compared with monotherapy with an LHRH agonist. 6/23/2009
Melissa M Murphy, Jessica P Simons, Joshua S Hill, Theodore P McDade, Sing Chau Ng, Giles F Whalen, Shimul A Shah, Lynn H Harrison, Jennifer F Tseng Pancreatic resection: a key component to reducing racial disparities in pancreatic adenocarcinoma CONCLUSIONS: Black and white patients with pancreatic adenocarcinoma presented with similar stages and were recommended for pancreatectomy at similar rates, yet black patients underwent fewer resections. After resection, crude survival did not differ significantly between white and black patients, a... 6/11/2009
Jessica P Simons, Shimul A Shah, Sing Chau Ng, Giles F Whalen, Jennifer F Tseng National complication rates after pancreatectomy: beyond mere mortality CONCLUSIONS: Despite improvements in mortality, complication rates remain substantial and largely unchanged. They predict in-hospital mortality, prolonged hospital stay, and delayed return to home. The impact on healthcare costs and quality of life deserves further study. 6/10/2009
Bruno Catimel, Meng-Xin Yin, Christine Schieber, Melanie Condron, Heather Patsiouras, Jenny Catimel, Diane E J E Robinson, Leon S-M Wong, Edouard C Nice, Andrew B Holmes, Antony W Burgess PI(3,4,5)P3 Interactome Immobilizing chemically synthesized analogues of PI(3,4,5)P3 onto Affi-10 beads and incorporating them into liposomes allowed their use as affinity absorbents in the comprehensive analysis of the phosphoinositide interactome using cytosolic cell extracts of the LIM1215 colon cancer cell line. This l... 5/26/2009
Omar A Zeidan, Adam J Huddleston, Choonik Lee, Katja M Langen, Patrick A Kupelian, Sanford L Meeks, Rafael R Manon A comparison of soft-tissue implanted markers and bony anatomy alignments for image-guided treatments of head-and-neck cancers CONCLUSION: The use of daily MVCT imaging demonstrates that implanted markers in oral tongue and soft-palate cancers are stable localization surrogates. Alignments based on implanted markers generate shifts comparable overall to the traditional bony-based alignment, with no observed systematic diffe... 5/12/2009
Daniel Landau, Renanah Eshet, Ariel Troib, Yotam Gurman, Yu Chen, Ralph Rabkin, Yael Segev Increased renal Akt/mTOR and MAPK signaling in type I diabetes in the absence of IGF type 1 receptor activation Growth hormone (GH) and IGF-I have been implicated in the pathogenesis of type I diabetic (DM) nephropathy. We investigated renal GH receptor (GHR) and IGF-type 1 receptor (IGF1R) signaling in an animal model of type I DM. Kidney tissue was examined for GHR and IGF1R key signaling molecules. GHR lev... 4/24/2009
Sanjeev Kumar, Christopher S Bryant, Sreedhar Chamala, Aamer Qazi, Shelly Seward, Jagannath Pal, Christopher P Steffes, Donald W Weaver, Robert Morris, John M Malone, Masood A Shammas, Madhu Prasad, Ramesh B Batchu Ritonavir blocks AKT signaling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells CONCLUSION: Our results demonstrate a potential use of ritonavir for ovarian cancer with additive effects in conjunction with conventional chemotherapeutic regimens. Since ritonavir is clinically approved for human use for HIV, drug repositioning for ovarian cancer could accelerate the process of tr... 4/24/2009
Thomas H Wagner, Katja M Langen, Sanford L Meeks, Twyla R Willoughby, Omar A Zeidan, Robert J Staton, Amish P Shah, Rafael R Manon, Patrick A Kupelian Megavoltage computed tomography image-based low-dose rate intracavitary brachytherapy planning for cervical carcinoma Initial results of megavoltage computed tomography (MVCT) brachytherapy treatment planning are presented, using a commercially available helical tomotherapy treatment unit and standard low dose rate (LDR) brachytherapy applicators used for treatment of cervical carcinoma. The accuracy of MVCT imagin... 4/2/2009
Tomas Dvorak, Arkadiy Finn, Lori Lyn Price, John E Mignano, Markus M Fitzek, Julian K Wu, Kevin C Yao Retreatment of trigeminal neuralgia with Gamma Knife radiosurgery: is there an appropriate cumulative dose? Clinical article CONCLUSIONS: Successful retreatment of patients in whom the initial GKS treatment fails is feasible. Patients who respond initially may be at a higher risk of retreatment-related complications. There appears to be a dose-response relationship for both pain control and development of new side effects... 3/31/2009
Robert W Eppsteiner, Nicholas G Csikesz, James T McPhee, Jennifer F Tseng, Shimul A Shah Surgeon volume impacts hospital mortality for pancreatic resection CONCLUSIONS: After controlling for patient demographics and factors, pancreatic resection by a HV surgeon in this case-controlled cohort was independently associated with a 51% reduction in in-hospital mortality. 3/21/2009
Erin K Cooley, James T McPhee, Jessica P Simons, W Brian Sweeney, Jennifer F Tseng, Karim Alavi Colorectal neoplasia screening before age 50?: current epidemiologic trends in the United States CONCLUSIONS: Although the national incidence of colorectal cancer has been fairly stable, the increase in colorectal resection for neoplasia in patients less than age 50, combined with their low in-hospital mortality rate, strengthens the argument for screening before age 50. The predominance of rig... 3/13/2009
Nicholas G Csikesz, Louis N Nguyen, Jennifer F Tseng, Shimul A Shah Nationwide volume and mortality after elective surgery in cirrhotic patients CONCLUSIONS: In-hospital mortality, length of stay, and total hospital charges are significantly higher after elective surgery in cirrhotic patients, even in the absence of portal hypertension. Careful decision-making about surgery in these patients is critical as the nationwide increase in hepatiti... 2/21/2009
Sanjeev Kumar, Jay P Shah, Christopher S Bryant, Shelly Seward, Rouba Ali-Fehmi, Robert T Morris, John M Malone Radiation-associated endometrial cancer CONCLUSION: The radiation-associated endometrial cancers carry a grave prognosis because they are more likely to be nonendometrioid, poorly differentiated advanced stage cancers. The longer latency and extensive spread at diagnosis among radiation-associated endometrial cancers may suggest a possibl... 1/22/2009
Akash Nanda, Ming-Hui Chen, Andrew A Renshaw, Anthony V D'Amico Gleason Pattern 5 prostate cancer: further stratification of patients with high-risk disease and implications for future randomized trials CONCLUSIONS: Our results highlight the importance of further substratification of the high-risk Gleason Score category of 8-10 into 8 vs. 9, 10, and 7 with tertiary Grade 5. 1/10/2009
Joshua S Hill, James T McPhee, Theodore P McDade, Zheng Zhou, Mary E Sullivan, Giles F Whalen, Jennifer F Tseng Pancreatic neuroendocrine tumors: the impact of surgical resection on survival CONCLUSIONS: The authors have demonstrated in a large national study that resection of primary tumor in patients with PNETs is associated with improved survival across all disease stages. Patients with localized, regional, and metastatic PNETs who are reasonable operative candidates should be consid... 1/9/2009
Santosh Kesari, David Schiff, Jan Drappatz, Debra LaFrankie, Lisa Doherty, Eric A Macklin, Alona Muzikansky, Sandro Santagata, Keith L Ligon, Andrew D Norden, Abigail Ciampa, Joanna Bradshaw, Brenda Levy, Gospova Radakovic, Naren Ramakrishna, Peter M Black, Patrick Y Wen Phase II study of protracted daily temozolomide for low-grade gliomas in adults CONCLUSIONS: A protracted course of daily temozolomide is a well-tolerated regimen and seems to produce effective tumor control. This compares favorably with historical data on the standard 5-day temozolomide regimen. 1/2/2009
Akash Nanda, Dora C Dias-Santagata, Hannah Stubbs, Carl J O'Hara, Ken S Zaner, Thomas J Lynch, Henning Willers Unusual tumor response and toxicity from radiation and concurrent erlotinib for non-small-cell lung cancer We report a case of a never-smoker female with non-small-cell lung cancer (NSCLC) who experienced a striking tumor response to combined low-dose radiation and the epidermal growth factor receptor inhibitor erlotinib, even though erlotinib alone was not effective in preventing tumor progression. Furt... 10/1/2008
Gema Ariceta, Nesrin Besbas, Sally Johnson, Diana Karpman, Daniel Landau, Christoph Licht, Chantal Loirat, Carmine Pecoraro, C Mark Taylor, Nicole Van de Kar, Johan Vandewalle, Lothar B Zimmerhackl, European Paediatric Study Group for HUS Guideline for the investigation and initial therapy of diarrhea-negative hemolytic uremic syndrome This guideline for the investigation and initial treatment of atypical hemolytic uremic syndrome (HUS) is intended to offer an approach based on opinion, as evidence is lacking. It builds on the current ability to identify the etiology of specific diagnostic sub-groups of HUS. HUS in children is mos... 9/19/2008
Choonik Lee, Katja M Langen, Weiguo Lu, Jason Haimerl, Eric Schnarr, Kenneth J Ruchala, Gustavo H Olivera, Sanford L Meeks, Patrick A Kupelian, Thomas D Shellenberger, Rafael R Mañon Evaluation of geometric changes of parotid glands during head and neck cancer radiotherapy using daily MVCT and automatic deformable registration CONCLUSION: The deformable image registration and daily MVCT images provide an efficient and reliable assessment of parotid changes over the course of a radiation therapy. 8/19/2008
Robert W Eppsteiner, Nicholas G Csikesz, Jessica P Simons, Jennifer F Tseng, Shimul A Shah High volume and outcome after liver resection: surgeon or center? CONCLUSIONS: A socioeconomic bias may exist at HV centers. When these factors are accounted for and adjusted, center volume does not appear to influence in-hospital mortality unless LR is performed by HV surgeons at HV centers. 8/16/2008
Claire Marie-Elisabeth Sauvageot, Jessica Leigh Weatherbee, Santosh Kesari, Susan Elizabeth Winters, Jessica Barnes, Jamie Dellagatta, Naren Raj Ramakrishna, Charles Dean Stiles, Andrew Li-Jen Kung, Mark W Kieran, Patrick Yung Chih Wen Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells Glioblastoma multiforme (GBM) arises from genetic and signaling abnormalities in components of signal transduction pathways involved in proliferation, survival, and the cell cycle axis. Studies to date with single-agent targeted molecular therapy have revealed only modest effects in attenuating the ... 8/7/2008
Nicholas Csikesz, Rocco Ricciardi, Jennifer F Tseng, Shimul A Shah Current status of surgical management of acute cholecystitis in the United States CONCLUSIONS: Most patients in the 21st century with AC undergo LC with a low conversion rate and low morbidity. In the general population with acute cholecystitis, LC results in lower morbidity and mortality rates than OC even in the setting of open conversion. 8/1/2008
F Stephen Hodi, Darryl A Oble, Jan Drappatz, Elsa F Velazquez, Nikhil Ramaiya, Naren Ramakrishna, Arthur L Day, Andrea Kruse, Suzanne Mac Rae, Axel Hoos, Martin Mihm CTLA-4 blockade with ipilimumab induces significant clinical benefit in a female with melanoma metastases to the CNS BACKGROUND: A 63-year-old female presented to her primary physician with numbness and weakness in her left leg, which progressed over several days to involve her entire lower extremities. MRI of the spine and brain revealed multiple metastases. The patient received ipilimumab and after 3 months expe... 7/31/2008
Nicholas G Csikesz, Jennifer F Tseng, Shimul A Shah Trends in surgical management for acute cholecystitis CONCLUSIONS: LC is performed with increasing frequency as the treatment for AC with lesser mortality, hospital stay, and cost compared with OC. Despite differences in cohorts, these results support a continued aggressive approach with laparoscopy as the treatment of choice for AC. 7/29/2008
Nicholas G Csikesz, Jessica P Simons, Jennifer F Tseng, Shimul A Shah Surgical specialization and operative mortality in hepato-pancreatico-biliary (HPB) surgery INTRODUCTION: Surgeon specialization has been shown to result in improved outcomes but may not be the sole measure of surgical quality in hepato-pancreatico-biliary (HPB) surgery. We attempted to determine which factors predominate in optimal patient outcomes between volume, surgeon, and hospital re... 7/10/2008
Waddah B Al-Refaie, Jennifer F Tseng, Greer Gay, Lina Patel-Parekh, Paul F Mansfield, Peter W T Pisters, James C Yao, Barry W Feig The impact of ethnicity on the presentation and prognosis of patients with gastric adenocarcinoma. Results from the National Cancer Data Base CONCLUSIONS: Ethnicity was associated with differences in presentation and outcome of patients with gastric adenocarcinoma. APIs had a more favorable outcome than patients of other ethnicities. Further studies should target underlying biologic and socioeconomic factors to explain these differences. 6/17/2008
Choonik Lee, Katja M Langen, Weiguo Lu, Jason Haimerl, Eric Schnarr, Kenneth J Ruchala, Gustavo H Olivera, Sanford L Meeks, Patrick A Kupelian, Thomas D Shellenberger, Rafael R Mañon Assessment of parotid gland dose changes during head and neck cancer radiotherapy using daily megavoltage computed tomography and deformable image registration CONCLUSIONS: The use of deformable image registration techniques and daily megavoltage computed tomography imaging makes it possible to calculate daily and accumulated dose-volume histograms. Significant dose variations were observed as result of interfractional anatomic changes. These techniques en... 6/10/2008
Jan Drappatz, Eric T Wong, David Schiff, Santosh Kesari, Tracy T Batchelor, Lisa Doherty, Debra Conrad Lafrankie, Naren Ramakrishna, Stephanie Weiss, Sharon T Smith, Abigail Ciampa, Jennifer Zimmerman, Louis Ostrowsky, Karly David, Andrew Norden, Loretta Barron, Christine Sceppa, Peter M Black, Patrick Y Wen A pilot safety study of lenalidomide and radiotherapy for patients with newly diagnosed glioblastoma multiforme CONCLUSION: The recommended dose for lenalidomide with radiotherapy is 15 mg/m(2)/d for 3 weeks followed by a 1-week rest period. Venous thromboembolic complications occurred in 4 patients, and prophylactic anticoagulation should be considered. 6/3/2008
Rogerio Lilenbaum, Luis Raez, Jennifer Tseng, Leonard Seigel, Enrique Davila Efficacy and safety of oxaliplatin and gemcitabine with bevacizumab in advanced non-small cell lung cancer CONCLUSIONS: The results of this phase II study suggest that oxaliplatin and gemcitabine with bevacizumab was active and reasonably well tolerated. Median TTP approached that in phase III studies. This combination represents another treatment option for advanced NSCLC. 5/2/2008
Santosh Kesari, David Schiff, John W Henson, Alona Muzikansky, Debra C Gigas, Lisa Doherty, Tracy T Batchelor, Janina A Longtine, Keith L Ligon, Susan Weaver, Andrea Laforme, Naren Ramakrishna, Peter McL Black, Jan Drappatz, Abigail Ciampa, Judah Folkman, Mark Kieran, Patrick Y Wen Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults We conducted a phase II study of the combination of temozolomide and angiogenesis inhibitors for treating adult patients with newly diagnosed glioblastoma. Patients who had stable disease following standard radiation therapy received temozolomide for 5 days in 28-day cycles, in combination with dail... 4/12/2008
Daniel Landau, Chen Chayat, Nili Zucker, Eli Golomb, Channa Yagil, Yoram Yagil, Yael Segev Early blood pressure-independent cardiac changes in diabetic rats Cardiac remodeling is a key event in both diabetic and hypertensive heart diseases. In the present study, we investigated early myocardial changes in an animal model, the male Sabra rat model (SBH/y) of salt-induced hypertension-rendered diabetic with streptozotocin. Control non-diabetic (C), diabet... 3/29/2008
Patrick A Kupelian, Katja M Langen, Twyla R Willoughby, Omar A Zeidan, Sanford L Meeks Image-guided radiotherapy for localized prostate cancer: treating a moving target Prostate motion during external-beam radiotherapy can affect outcomes in patients with localized prostate cancer. Prostate motion and deformation are currently being characterized with different techniques. There is significant individual variation among patients with respect to the observed motion ... 12/18/2007
Jennifer F Tseng Management of serous cystadenoma of the pancreas Serous cystadenoma of the pancreas is a diagnosis being entertained with increasing frequency. The histopathologic findings, diagnostic strategy, differential diagnosis, and treatment strategy of these generally benign but sometimes symptomatic lesions are discussed. Based on the available case seri... 10/27/2007
Patrick A Kupelian, Choonik Lee, Katja M Langen, Omar A Zeidan, Rafael R Mañon, Twyla R Willoughby, Sanford L Meeks Evaluation of image-guidance strategies in the treatment of localized prostate cancer CONCLUSION: Setup errors increased with decreasing frequency of image guidance. However, residual errors were still significant at the 5-mm level, even with imaging was performed every other day. This suggests that localizations must be performed daily in the set up of prostate cancer patients durin... 9/26/2007
Daniel Landau Diagnostic tests for urinary tract infection The clinical suspicion for urinary tract infection usually begins with simple laboratory aid: the urinalysis, performed many times in a small laboratory by the physician himself. A well-performed urinalysis can still provide valuable information for many diseases, including urinary tract infection. ... 9/15/2007
James T McPhee, Joshua S Hill, Giles F Whalen, Maksim Zayaruzny, Demetrius E Litwin, Mary E Sullivan, Frederick A Anderson, Jennifer F Tseng Perioperative mortality for pancreatectomy: a national perspective CONCLUSIONS: This large observational study demonstrates an improvement in operative mortality for patients undergoing pancreatectomy for neoplastic disease from 1998 to 2003. In addition, a greater proportion of pancreatectomies were performed at high-volume centers in 2003. The regionalization of ... 8/2/2007
Patrick A Kupelian, Alan Forbes, Twyla R Willoughby, Karen Wallace, Rafael R Mañon, Sanford L Meeks, Luis Herrera, Alan Johnston, Juan J Herran Implantation and stability of metallic fiducials within pulmonary lesions CONCLUSIONS: Transbronchial marker placement is less invasive than transcutaneous placement, which is associated with high pneumothorax rates. Although marker geometry can be affected by tumor shrinkage, implanted markers are stable within tumors throughout the treatment duration regardless of impla... 7/4/2007
Chandrajit P Raut, Jennifer F Tseng, Charlotte C Sun, Huamin Wang, Robert A Wolff, Christopher H Crane, Rosa Hwang, Jean-Nicolas Vauthey, Eddie K Abdalla, Jeffrey E Lee, Peter W T Pisters, Douglas B Evans Impact of resection status on pattern of failure and survival after pancreaticoduodenectomy for pancreatic adenocarcinoma CONCLUSIONS: There was no statistically significant difference in patient survival or recurrence based on R status. However, this series is unique in the incorporation of a standardized surgical technique for the SMA dissection, the prospective use of a reproducible system for pathologic evaluation ... 6/27/2007
Tiezhi Zhang, Weiguo Lu, Gustavo H Olivera, Harry Keller, Robert Jeraj, Rafael Manon, Minesh Mehta, Thomas R Mackie, Bhudatt Paliwal Breathing-synchronized delivery: a potential four-dimensional tomotherapy treatment technique CONCLUSION: Breathing-synchronized delivery is a feasible 4D tomotherapy treatment technique with improved motion control and patient tolerance. 6/16/2007
Jennifer F Tseng, Peter W T Pisters, Jeffrey E Lee, Huamin Wang, Henry F Gomez, Charlotte C Sun, Douglas B Evans The learning curve in pancreatic surgery CONCLUSIONS: Pancreaticoduodenectomy has an inherent learning curve. After 60 cases, surgeons achieved significantly decreased EBL, operative time, and LOS, and carried out more margin-negative resections. Improvement in measured outcomes continues during the operative career. 5/22/2007
Santosh Kesari, David Schiff, Lisa Doherty, Debra C Gigas, Tracy T Batchelor, Alona Muzikansky, Alison O'Neill, Jan Drappatz, Alice S Chen-Plotkin, Naren Ramakrishna, Stephanie E Weiss, Brenda Levy, Joanna Bradshaw, Jean Kracher, Andrea Laforme, Peter McL Black, Judah Folkman, Mark Kieran, Patrick Y Wen Phase II study of metronomic chemotherapy for recurrent malignant gliomas in adults Preclinical evidence suggests that continuous low-dose daily (metronomic) chemotherapy may inhibit tumor endothelial cell proliferation (angiogenesis) and prevent tumor growth. This phase II study evaluated the feasibility of this antiangiogenic chemotherapy regimen in adults with recurrent malignan... 4/25/2007
Jillian K Smith, James T McPhee, Joshua S Hill, Giles F Whalen, Mary E Sullivan, Demetrius E Litwin, Frederick A Anderson, Jennifer F Tseng National outcomes after gastric resection for neoplasm CONCLUSIONS: Higher annual surgical volume is predictive of lower in-hospital mortality for patients undergoing gastric resection for neoplasm. Other factors significantly associated with superior outcomes after gastric resection included diagnosis type, procedure type, younger age, female sex, and ... 4/20/2007
Theresa G Cargioli, Hasan C Ugur, Naren Ramakrishna, Jennifer Chan, Peter M Black, Rona S Carroll Establishment of an in vivo meningioma model with human telomerase reverse transcriptase CONCLUSION: The Me3TSC and Me10T cell lines can serve as useful model systems for biological studies and the evaluation of novel therapies on meningioma. 4/7/2007
Jennifer F Tseng, Peter W T Pisters, Jeffrey E Lee, Huamin Wang, Henry F Gomez, Charlotte C Sun, Douglas B Evans The learning curve in pancreatic surgery CONCLUSIONS: Pancreaticoduodenectomy has an inherent learning curve. After 60 cases, surgeons achieved significantly decreased EBL, operative time, and LOS, and carried out more margin-negative resections. Improvement in measured outcomes continues during the operative career. 3/27/2007
Felix G Hamza-Lup, Ivan Sopin, Omar Zeidan Comprehensive 3D visual simulation for radiation therapy planning External beam radiation therapy is concerned with the precise and accurate delivery of radiation for cancer treatment. Highly-collimated beams are generated in a linear accelerator, consisting of several hardware components that move around the patient in a complex geometry to allow radiation target... 3/23/2007
Hava Peretz, Meirav Shtauber Naamati, David Levartovsky, Ayala Lagziel, Esther Shani, Ivona Horn, Hanna Shalev, Daniel Landau Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS) associated with type II classical xanthinuria Classical xanthinuria type II is an autosomal recessive disorder characterized by deficiency of xanthine dehydrogenase and aldehyde oxidase activities due to lack of a common sulfido-olybdenum cofactor (MoCo). Two mutations, both in the N-terminal domain of the Human Molybdenum Cofactor Sulfurase (H... 3/21/2007
Michelle L Monje, Naren R Ramakrishna, Geoffrey Young, Jan Drappatz, Lisa M Doherty, Patrick Y Wen, Santosh Kesari Durable response of a radiation-induced, high-grade cerebellar glioma to temozolomide CONCLUSION: High-grade gliomas are a late complication of radiation to the central nervous system and may respond to chemotherapy. 3/3/2007
Hasan C Ugur, Naren Ramakrishna, Lorenzo Bello, Lata G Menon, Seung-Ki Kim, Peter M Black, Rona S Carroll Continuous intracranial administration of suberoylanilide hydroxamic acid (SAHA) inhibits tumor growth in an orthotopic glioma model CONCLUSIONS: These results suggest that local delivery with SAHA inhibits intracranial glioma growth in vitro and in vivo. SAHA is a promising candidate for further preclinical and clinical studies on glial tumors. 2/21/2007
Daniel Landau, Tal Oved, Dan Geiger, Luba Abizov, Hanna Shalev, Ruti Parvari Familial steroid-sensitive nephrotic syndrome in Southern Israel: clinical and genetic observations Reports on genetically informative steroid-responsive (sensitive) idiopathic nephrotic syndrome (SSNS) families are lacking. We studied an extended SSNS Bedouin (B) family with a high rate of consanguinity. The clinical presentation and steroid response of its 11 affected individuals were similar to... 1/16/2007
Philip Axe, Steven D Bull, Matthew G Davidson, Carly J Gilfillan, Matthew D Jones, Diane E J E Robinson, Luke E Turner, William L Mitchell Enantiopure pseudo-C3-symmetric titanium alkoxide with propeller-like chirality An enantiopure amine tris(phenolate) ligand containing a single stereogenic center has been used to control the propeller-like chirality of a derived pseudo-C3-symmetric titanium isopropoxide complex with excellent levels of diastereocontrol. [structure: see text]. 1/16/2007
Omar A Zeidan, Katja M Langen, Sanford L Meeks, Rafael R Manon, Thomas H Wagner, Twyla R Willoughby, D Wayne Jenkins, Patrick A Kupelian Evaluation of image-guidance protocols in the treatment of head and neck cancers CONCLUSION: Residual setup errors reduce with increasing frequency of IG during the course of external-beam radiotherapy for head-and-neck cancer patients. The inability to reduce random setup errors for fractions that are not image guided results in notable residual setup errors. 1/2/2007
Daniel Landau, Hanna Krymko, Hanna Shalev, Svetlana Agronovich Transient severe metastatic calcification in acute renal failure Metastatic calcification, a known complication of prolonged end-stage renal disease, is herein described for the first time in a 10-month-old boy with acute renal failure, manifesting as a painful and swollen arm. Imaging revealed diffuse calcification and technetium-99 methylene diphosphonate (99Tc... 12/23/2006
Omar A Zeidan, Stacy Ann L Stephenson, Sanford L Meeks, Thomas H Wagner, Twyla R Willoughby, Patrick A Kupelian, Katja M Langen Characterization and use of EBT radiochromic film for IMRT dose verification We present an evaluation of a new and improved radiochromic film, type EBT, for its implementation to IMRT dose verification. Using a characterized flat bed color CCD scanner, the film's dose sensitivity, uniformity, and speed of development post exposure were shown to be superior to previous types ... 12/13/2006
Luis J Herrera, Arlene M Correa, Ara A Vaporciyan, Wayne L Hofstetter, David C Rice, Stephen G Swisher, Garrett L Walsh, Jack A Roth, Reza J Mehran Increased risk of aspiration and pulmonary complications after lung resection in head and neck cancer patients CONCLUSIONS: Patients with HNC have an increased risk of aspiration pneumonia after pulmonary resection. Evaluation of swallowing function to identify aspiration is indicated in HNC patients before pulmonary resection to avoid the morbidity and prolonged hospitalization associated with aspiration pn... 11/28/2006
Patrick A Kupelian, Katja M Langen, Omar A Zeidan, Sanford L Meeks, Twyla R Willoughby, Thomas H Wagner, Sam Jeswani, Kenneth J Ruchala, Jason Haimerl, Gustavo H Olivera Daily variations in delivered doses in patients treated with radiotherapy for localized prostate cancer CONCLUSION: Large variations in delivered doses to the rectum and bladder can be documented with daily megavoltage CT scans. Image guidance for the targeting of the prostate, even with intraprostatic fiducials, does not take into account the variation in actual rectal and bladder doses. The clinical... 10/3/2006
Patrick A Kupelian, Katja M Langen, Twyla R Willoughby, Thomas H Wagner, Omar A Zeidan, Sanford L Meeks Daily variations in the position of the prostate bed in patients with prostate cancer receiving postoperative external beam radiation therapy CONCLUSION: In patients with prostate cancer receiving postoperative radiotherapy, the prostate bed motion relative to the pelvic bony anatomy is of a relatively small magnitude. Significant motion (>or=3 mm) is infrequent. However, small differences between the prostate bed and the bony anatomy sti... 9/13/2006
Jennifer F Tseng, Matthew T Ballo, Howard N Langstein, Jeffrey D Wayne, Janice N Cormier, Kelly K Hunt, Barry W Feig, Alan W Yasko, Valerae O Lewis, Patrick P Lin, Christopher P Cannon, Gunar K Zagars, Raphael E Pollock, Peter W T Pisters The effect of preoperative radiotherapy and reconstructive surgery on wound complications after resection of extremity soft-tissue sarcomas CONCLUSIONS: MWCs are frequent after preoperative RT and occur more commonly in patients with lower extremity tumors. The MWC rate observed in a single-institution setting was comparable to that observed in the preoperative therapy arm of a multicenter Canadian trial. Patients believed to be at high... 9/5/2006
Twyla R Willoughby, Alan R Forbes, Daniel Buchholz, Katja M Langen, Thomas H Wagner, Omar A Zeidan, Patrick A Kupelian, Sanford L Meeks Evaluation of an infrared camera and X-ray system using implanted fiducials in patients with lung tumors for gated radiation therapy CONCLUSION: ExacTrac Adaptive Gating has been used to treat lung lesions. Initial system evaluation verified its accuracy and usability. Implanted fiducials are visible in X-rays and did not migrate. 8/5/2006
Luis J Herrera, John W Davis, James J Livesay Popliteal vein aneurysm presenting as a popliteal mass Unlike most primary venous aneurysms, popliteal venous aneurysms can have devastating consequences, including pulmonary embolism and death. We present a case of popliteal venous aneurysm in a 27-year-old man who had local extremity symptoms and no thromboembolic complications. The fusiform 6- x 3-cm... 8/2/2006
Florin Rosca, Friedlieb Lorenz, Fred L Hacker, Lee M Chin, Naren Ramakrishna, Piotr Zygmanski An MLC-based linac QA procedure for the characterization of radiation isocenter and room lasers' position We have designed and implemented a new stereotactic linac QA test with stereotactic precision. The test is used to characterize gantry sag, couch wobble, cone placement, MLC offsets, and room lasers' positions relative to the radiation isocenter. Two MLC star patterns, a cone pattern, and the laser ... 7/29/2006
Daniel Landau Epithelial paracellular proteins in health and disease PURPOSE OF REVIEW: Tight junctions are intercellular seams sealing and preventing the entrance of microorganisms or unwanted substances from the luminal compartment. They also define the border between the basolateral and apical membranes of polarized cells, thus enabling the normal transcellular ve... 6/16/2006
Gal Finer, Hanna Shalev, Daniel Landau Genetic kidney diseases in the pediatric population of southern Israel Genetic kidney diseases (GKDs) are an important and well-known entity in pediatric nephrology. In the past decade advances in genetic and molecular approaches have enabled elucidation of the underlying molecular defects in many of these disorders. Herein we summarize the progress that has been made ... 6/15/2006
L Bernd Zimmerhackl, Nesir Besbas, Therese Jungraithmayr, Nicole van de Kar, Helge Karch, Diana Karpman, Daniel Landau, Chantal Loirat, Willem Proesmans, Friederike Prüfer, Gianfranco Rizzoni, Mark C Taylor, European Study Group for Haemolytic Uraemic Syndromes and Related Disorders Epidemiology, clinical presentation, and pathophysiology of atypical and recurrent hemolytic uremic syndrome Hemolytic uremic syndrome (HUS) includes a heterogeneous group of hemolytic disorders. Among the identified causes of HUS are infections, particularly infections with Shiga toxin-producing ESCHERICHIA COLI (STEC), complement disorders, and disorders interfering with the degradation of von Willebrand... 4/1/2006
Jennifer F Tseng, Eric P Tamm, Jeffrey E Lee, Peter W T Pisters, Douglas B Evans Venous resection in pancreatic cancer surgery Vascular resection and reconstruction at the time of pancreaticoduodenectomy (PD) adds complexity to an already demanding operation. In this chapter, we review the indications, surgical techniques, and most recent results of venous resection combined with PD. The need for venous resection may not al... 3/22/2006
Akash Nanda, Baktiar Karim, Zhongsheng Peng, Guosheng Liu, Weiping Qiu, Christine Gan, Bert Vogelstein, Brad St Croix, Kenneth W Kinzler, David L Huso Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors Tumor endothelial marker 1 (Tem1; endosialin) is the prototypical member of a family of genes expressed in the stroma of tumors. To assess the functional role of Tem1, we disrupted the Tem1 gene in mice by targeted homologous recombination. Tem1(-/-) mice were healthy, their wound healing was normal... 2/24/2006
Santosh Kesari, Naren Ramakrishna, Claire Sauvageot, Charles D Stiles, Patrick Y Wen Targeted molecular therapy of malignant gliomas Malignant gliomas are the most common form of primary brain tumors in adults. Despite advances in diagnosis and standard therapies such as surgery, radiation, and chemotherapy, the prognosis remains poor. Recent scientific advances have enhanced our understanding of the biology of gliomas and the ro... 2/9/2006
Daniel Landau Potassium handling in health and disease: lessons from inherited tubulopathies The tight regulation of plasma potassium levels, a mostly intracellular cation, is essential given the severe consequences of hyper- and hypokalemia. Basic renal physiology studies in the past have identified the complex pathway of potassium reabsorption in the proximal tubule followed by the fine-t... 1/24/2006
Rafael Manon, Anne O'Neill, Jonathan Knisely, Maria Werner-Wasik, Hillard M Lazarus, Henry Wagner, Mark Gilbert, Minesh Mehta, Eastern Cooperative Oncology Group Phase II trial of radiosurgery for one to three newly diagnosed brain metastases from renal cell carcinoma, melanoma, and sarcoma: an Eastern Cooperative Oncology Group study (E 6397) CONCLUSION: Intracranial failure rates without WBRT were 25.8% and 48.3% at 3 and 6 months, respectively. Delaying WBRT may be appropriate for some subgroups of patients with radioresistant tumors, but routine avoidance of WBRT should be approached judiciously. 11/30/2005
Francisco Robert, George Blumenschein, Roy S Herbst, Frank V Fossella, Jennifer Tseng, Mansoor N Saleh, Michael Needle Phase I/IIa study of cetuximab with gemcitabine plus carboplatin in patients with chemotherapy-naive advanced non-small-cell lung cancer CONCLUSION: The combination of cetuximab, carboplatin, and gemcitabine was well tolerated with an acceptable toxicity profile. Most grade 3 adverse events were attributable to chemotherapy. The response rate and median survival are encouraging and warrant additional investigation. 11/23/2005
Rafael Mañon, Minesh Mehta Strategies for enhanced radiation delivery in patients with lung cancer Since the 1970s primary management for regionally advanced non-small cell lung cancer has shifted from radiotherapy alone to sequential chemoradiation to concurrent chemoradiation. The increase in survival with these approaches has been small; an approximately 3-4 month per decade increase in median... 11/22/2005
Tomas Dvorak, Ming-Hui Chen, Andrew A Renshaw, Marian Loffredo, Jerome P Richie, Anthony V D'Amico Maximal tumor diameter and the risk of PSA failure in men with specimen-confined prostate cancer CONCLUSIONS: Whether patients with traditionally low-risk but large MTD prostate cancer fare better when treated with adjuvant radiotherapy compared with salvage radiotherapy remains to be answered in the setting of a randomized trial. 11/16/2005
Susanta K Hui, Jeff Kapatoes, Jack Fowler, Douglas Henderson, Gustavo Olivera, Rafael R Manon, Bruce Gerbi, T R Mackie, James S Welsh Feasibility study of helical tomotherapy for total body or total marrow irradiation Total body radiation (TBI) has been used for many years as a preconditioning agent before bone marrow transplantation. Many side effects still plague its use. We investigated the planning and delivery of total body irradiation (TBI) and selective total marrow irradiation (TMI) and a reduced radiatio... 11/11/2005
Rafael R Manon, Hazim Jaradat, Rakesh Patel, Tiezhi Zhang, John Fenwick, Wolfgang Tome, Jack Fowler, Bhudatt Paliwal, Emilie Soisson, Zhilong Yuan, Minesh Mehta Potential for radiation therapy technology innovations to permit dose escalation for non-small-cell lung cancer CONCLUSION: Treatment in MIBH results in lower V20 and NTDmean values and lower modeled pneumonitis rates. This effect is enhanced by the use of IMRT. The use of MIBH with IMRT may therefore aid in escalating the dose in RT. 9/24/2005
Jennifer F Tseng, Andrew L Warshaw, Dushyant V Sahani, Gregory Y Lauwers, David W Rattner, Carlos Fernandez-del Castillo Serous cystadenoma of the pancreas: tumor growth rates and recommendations for treatment CONCLUSIONS: Large (>4 cm) serous cystadenomas are more likely to be symptomatic. Although the median growth rate for this neoplasm is only 0.6 cm/y, it is significantly greater in large tumors. Whereas expectant management is reasonable in small asymptomatic tumors, we recommend resection for large... 9/2/2005
Minesh Mehta, Rafael Manon Are more aggressive therapies able to improve treatment of locally advanced non-small cell lung cancer: combined modality treatment? Non-small cell lung cancer continues to be a major oncologic problem, with approximately 3-month increase in median survival per decade since the 1970s. Thus, newer strategies are needed to improve outcomes in non-small cell lung cancer. New treatment strategies include optimizing and intensifying r... 7/15/2005
Chien-Te K Tseng, Jennifer Tseng, Lucy Perrone, Melissa Worthy, Vsevolod Popov, Clarence J Peters Apical entry and release of severe acute respiratory syndrome-associated coronavirus in polarized Calu-3 lung epithelial cells Severe acute respiratory syndrome (SARS), caused by a novel coronavirus (CoV) known as SARS-CoV, is a contagious and life-threatening respiratory illness with pneumocytes as its main target. A full understanding of how SARS-CoV would interact with lung epithelial cells will be vital for advancing ou... 7/15/2005
Bethany M Duffy, Rafael Manon, Rakesh R Patel, James S Welsh A case of Gorham's disease with chylothorax treated curatively with radiation therapy Gorham's disease, also known as vanishing bone disease or massive osteolysis, is a rare disorder of uncertain etiology. It is characterized by uncontrolled proliferation of vascular or lymphatic capillaries within bone, leading to resorption and replacement with angiomatous tissue. It can be complic... 7/14/2005
Santosh Kesari, Naren Ramakrishna, Claire Sauvageot, Charles D Stiles, Patrick Y Wen Targeted molecular therapy of malignant gliomas Malignant gliomas are the most common form of primary brain tumors in adults. Despite advances in diagnosis and standard therapies such as surgery, radiation, and chemotherapy, the prognosis remains poor. Recent scientific advances have enhanced our understanding of the biology of gliomas and the ro... 5/4/2005
James C Yao, Jennifer F Tseng, Samidha Worah, Kenneth R Hess, Paul F Mansfield, Christopher H Crane, Isac I Schnirer, Satish Reddy, Silvia S Chiang, Azmeena Najam, Christina Yu, Geoffrey G Giacco, Keping Xie, Tsung-Teh Wu, Barry W Feig, Peter W T Pisters, Jaffer A Ajani Clinicopathologic behavior of gastric adenocarcinoma in Hispanic patients: analysis of a single institution's experience over 15 years CONCLUSION: Hispanic ethnicity does not impact survival in gastric adenocarcinoma. However, histology, metastasis pattern, tumor localization, and other clinical parameters differ sufficiently to warrant further investigation into the epidemiology, pathogenesis, and molecular biology of gastric canc... 4/30/2005
Jennifer F Tseng, Christopher G Willett, Carlos Fernandez-del Castillo, David P Ryan, Jeffrey W Clark, Andrew X Zhu, David W Rattner, Jennifer L Winkelmann, Andrew L Warshaw Patients undergoing treatment for pancreatic adenocarcinoma can mount an effective immune response to vaccinations CONCLUSIONS: Patients with pancreatic cancer were capable of mounting effective cellular and humoral responses to standard vaccines. These data suggest that immunotherapy for pancreatic cancer may be feasible and merits further investigation. 3/19/2005
Luis J Herrera, Talal El-Hefnawy, Pierre E Queiroz de Oliveira, Siva Raja, Sydney Finkelstein, William Gooding, James D Luketich, Tony E Godfrey, Steven J Hughes The HGF receptor c-Met is overexpressed in esophageal adenocarcinoma The hepatocyte growth factor (HGF) receptor, Met, has established oncogenic properties; however, its expression and function in esophageal adenocarcinoma (EA) remain poorly understood. We aimed to determine the expression and potential alterations in Met expression in EA. Met expression was investig... 2/22/2005
Gal Finer, Ohad Birk, Daniel Landau Genetic and phenotypic aspects of autosomal recessive polycystic kidney disease in southern Israel CONCLUSIONS: Phenotypic variability exists in ARPKD, even among families with supposedly homozygous mutations in the PKHD1 gene. We have established a reliable method for prenatal diagnosis of the disease by linkage analysis, thus enabling future diagnosis in families at risk. 1/27/2005
Jennifer F Tseng, Chandrajit P Raut, Jeffrey E Lee, Peter W T Pisters, Jean-Nicolas Vauthey, Eddie K Abdalla, Henry F Gomez, Charlotte C Sun, Christopher H Crane, Robert A Wolff, Douglas B Evans Pancreaticoduodenectomy with vascular resection: margin status and survival duration Major vascular resection performed at the time of pancreaticoduodenectomy (PD) for adenocarcinoma remains controversial. We analyzed all patients who underwent vascular resection (VR) at the time of PD for any histology at a single institution between 1990 and 2002. Preoperative imaging criteria for... 12/9/2004
Akash Nanda, Phillip Buckhaults, Steven Seaman, Nishant Agrawal, Paula Boutin, Srinivas Shankara, Mariana Nacht, Beverly Teicher, Jason Stampfl, Sujay Singh, Bert Vogelstein, Kenneth W Kinzler, Brad St Croix Identification of a binding partner for the endothelial cell surface proteins TEM7 and TEM7R Tumor endothelial marker 7 (TEM7) was recently identified as an mRNA transcript overexpressed in the blood vessels of human solid tumors. Here, we identify several new variants of TEM7, derived by alternative splicing, that are predicted to be intracellular (TEM7-I), secreted (TEM7-S), or on the cel... 12/3/2004
Omar A Zeidan, Jonathan G Li, Daniel A Low, James F Dempsey Comparison of small photon beams measured using radiochromic and silver-halide films in solid water phantoms In this study, we compared the dosimetric properties of four of the most commonly used films for megavoltage photon-beam dosimetry when irradiated under identical conditions by small multileaf-collimator (MLC) defined beamlets. Two silver-halide films (SHFs), Kodak XV2 and EDR2, and two radiochromic... 11/17/2004
Luis J Herrera, Siva Raja, William E Gooding, Talal El-Hefnawy, Lori Kelly, James D Luketich, Tony E Godfrey Quantitative analysis of circulating plasma DNA as a tumor marker in thoracic malignancies CONCLUSIONS: Our data indicate that plasma DNA concentrations are of limited diagnostic value when samples are prospectively collected and uniformly handled. This is in contrast to previously published results. Qualitative analysis of DNA may be needed if plasma nucleic acids are to be used as a dia... 11/13/2004
Yael Segev, Renanah Eshet, Inessa Rivkis, Chen Hayat, Leonid Kachko, Moshe Phillip, Daniel Landau Comparison between somatostatin analogues and ACE inhibitor in the NOD mouse model of diabetic kidney disease CONCLUSION: SST analogues exert beneficial effects in most parameters of diabetic kidney disease to the same extent as the ACEi. Enalapril treatment had no effect on renal hypertrophy and did not cause a significant decrease in mesangial type IV collagen deposition. A synergistic effect of combined ... 10/21/2004
Maciej M Mrugala, Santosh Kesari, Naren Ramakrishna, Patrick Y Wen Therapy for recurrent malignant glioma in adults Malignant gliomas are the most common form of primary brain tumors in adults. Although the prognosis remains poor, there has been recent progress in the treatment of these tumors. Standard therapy for patients with this disease will be reviewed, together with more novel approaches such as targeted m... 10/16/2004
Gal Finer, Daniel Landau Pathogenesis of urinary tract infections with normal female anatomy Recurrent urinary tract infections (UTIs) are common among girls and young women who are healthy and have anatomically normal urinary tracts. These infections are a main source of morbidity and health-care costs in this population. The interaction between specific infecting bacteria and urinary trac... 9/29/2004
Jennifer F Tseng, Steven J Kronowitz, Charlotte C Sun, Allison C Perry, Kelly K Hunt, Gildy V Babiera, Lisa A Newman, S Eva Singletary, Nadeem Q Mirza, Frederick C Ames, Funda Meric-Bernstam, Merrick I Ross, Barry W Feig, Geoffrey L Robb, Henry M Kuerer The effect of ethnicity on immediate reconstruction rates after mastectomy for breast cancer CONCLUSIONS: African-American women underwent immediate breast reconstruction at significantly lower rates compared with white women, Hispanic women, and Asian women. After adjusting for covariates, including age and disease stage, African-American women and Asian women had lower rates of reconstruc... 9/21/2004
Anthony M Stell, Jonathan G Li, Omar A Zeidan, James F Dempsey An extensive log-file analysis of step-and-shoot intensity modulated radiation therapy segment delivery errors We present a study to evaluate the monitor unit (MU), dosimetric, and leaf-motion errors found in the delivery of 91 step-and-shoot IMRT treatment plans performed at three nominal dose rates using a dual modality high energy Linac (Varian 2100 C/D, Varian Medical Systems Inc., Palo Alto, CA) equippe... 7/21/2004
Rafael Manon, Susanta Hui, Prakash Chinnaiyan, John Suh, Eric Chang, Robert Timmerman, See Phan, Rupak Das, Minesh Mehta The impact of mid-treatment MRI on defining boost volumes in the radiation treatment of glioblastoma multiforme Radiation therapy is a central modality in the treatment of glioblastoma multiforme (GBM). Integral to adequate radiation therapy delivery is the appropriate determination of tumor volume and extent at the time treatment is being delivered. As a matter of routine practice, radiation therapy treatmen... 5/27/2004
James S Welsh, Kristin Bradley, Kenneth J Ruchala, Thomas R Mackie, Rafael Mañon, Rakesh Patel, Peggy Wiederholt, Michael Lock, Susanta Hui, Minesh P Mehta Megavoltage computed tomography imaging: a potential tool to guide and improve the delivery of thoracic radiation therapy Helical tomotherapy is an innovative means of delivering intensity-modulated radiation therapy (IMRT) using a device that merges features of a linear accelerator and a helical computed tomography (CT) scanner. The tomotherapy unit can generate CT images from the megavoltage radiation it uses for tre... 4/17/2004
Omar A Zeidan, Jonathan G Li, Manisha Ranade, Anthony M Stell, James F Dempsey Verification of step-and-shoot IMRT delivery using a fast video-based electronic portal imaging device We present an investigation into the use of a fast video-based electronic portal-imaging device (EPID) to study intensity modulated radiation therapy (IMRT) delivery. The aim of this study is to test the feasibility of using an EPID system to independently measure the orchestration of collimator lea... 4/9/2004
Akash Nanda, Eleanor B Carson-Walter, Steven Seaman, Thomas D Barber, Jason Stampfl, Sujay Singh, Bert Vogelstein, Kenneth W Kinzler, Brad St Croix TEM8 interacts with the cleaved C5 domain of collagen alpha 3(VI) Tumor endothelial marker (TEM)8 was uncovered as a gene expressed predominantly in tumor endothelium, and its protein product was recently identified as the receptor for anthrax toxin. Here, we demonstrate that TEM8 protein is preferentially expressed in endothelial cells of neoplastic tissue. We us... 2/12/2004
Hanna Shalev, Igor Romanovsky, Nine V Knoers, Salomon Lupa, Daniel Landau Bladder function impairment in aquaporin-2 defective nephrogenic diabetes insipidus CONCLUSIONS: The severe renal concentrating defect in this type of NDI is associated with the development of hydroureteronephrosis followed by bladder enlargement and dysfunction. Careful follow-up is needed in order to assure that no bladder outlet obstruction and/or renal insufficiency develop. 2/10/2004
Akash Nanda, Brad St Croix Tumor endothelial markers: new targets for cancer therapy PURPOSE OF REVIEW: Targeting the endothelial cells that line tumor infiltrating blood vessels is a new anticancer strategy that has gained widespread support from biologists and clinicians. Here we highlight different approaches currently being used to target tumor endothelium and discuss new avenue... 12/20/2003
Peter B Johansen, Yael Segev, Daniel Landau, Moshe Phillip, Allan Flyvbjerg Growth hormone (GH) hypersecretion and GH receptor resistance in streptozotocin diabetic mice in response to a GH secretagogue The growth hormone (GH) and insulin-like growth factor I (IGF-I) axis were studied in streptozotocin (STZ) diabetic and nondiabetic female mice following intravenous (IV) injection of the GH secretagogue (GHS) ipamorelin or saline. On day 14, blood samples were obtained before and 10 minutes after t... 11/25/2003
Fred J P Feuillet, Diane E J E Robinson, Steven D Bull An (E)-selective synthesis of trisubstituted (E)-alpha,beta-unsaturated acid derivatives Potassium alkoxides of N-acyloxazolidin-2-one derived syn-aldolates undergo a novel tandem intramolecular cyclisation elimination reaction to afford trisubstituted (E)-alpha,beta-unsaturated amides in high d.e., which may be converted into their corresponding acids or oxazolines in good yield. 9/19/2003
Hanna Shalev, Melly Ohali, Leonid Kachko, Daniel Landau The neonatal variant of Bartter syndrome and deafness: preservation of renal function CONCLUSIONS: Early renal function deterioration is not a uniform finding among children with BSND mutations. 9/2/2003
Edgar A Otto, Bernhard Schermer, Tomoko Obara, John F O'Toole, Karl S Hiller, Adelheid M Mueller, Rainer G Ruf, Julia Hoefele, Frank Beekmann, Daniel Landau, John W Foreman, Judith A Goodship, Tom Strachan, Andreas Kispert, Matthias T Wolf, Marie F Gagnadoux, Hubert Nivet, Corinne Antignac, Gerd Walz, Iain A Drummond, Thomas Benzing, Friedhelm Hildebrandt Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination Nephronophthisis (NPHP), an autosomal recessive cystic kidney disease, leads to chronic renal failure in children. The genes mutated in NPHP1 and NPHP4 have been identified, and a gene locus associated with infantile nephronophthisis (NPHP2) was mapped. The kidney phenotype of NPHP2 combines clinica... 7/23/2003
Luis J Herrera, Hiran C Fernando, Yaron Perry, William E Gooding, Percival O Buenaventura, Neil A Christie, James D Luketich Radiofrequency ablation of pulmonary malignant tumors in nonsurgical candidates CONCLUSION: This pilot study demonstrates the feasibility of radiofrequency ablation for small peripheral lung tumors. Larger tumors responded poorly. Additional trials are needed to determine safety and efficacy. 4/17/2003
Gal Finer, Hanna Shalev, Ohad S Birk, Dalia Galron, Nikola Jeck, Levana Sinai-Treiman, Daniel Landau Transient neonatal hyperkalemia in the antenatal (ROMK defective) Bartter syndrome CONCLUSIONS: Early postnatal hyperkalemia, sometimes severe, may complicate antenatal BS associated with ROMK mutations. Its association with hyponatremia and hyperreninemic hyperaldosteronism may erroneously suggest the diagnosis of pseudohypoaldosteronism type 1. The expression of ROMK in both the... 3/18/2003
Daniel Landau, Eytan Israel, Inessa Rivkis, Leonid Kachko, Bieke F Schrijvers, Allan Flyvbjerg, Moshe Phillip, Yael Segev The effect of growth hormone on the development of diabetic kidney disease in rats CONCLUSIONS: GH-treated diabetic rats had less hyperfiltration and more albuminuria, concomitant with more glomerular matrix deposition, when compared with regular diabetic animals. This was associated with a significant increase in renal IGFBP-1, and dissociated from IGF-I changes. Thus, in this mo... 3/15/2003
Jennifer A Quinn, David A Reardon, Allan H Friedman, Jeremy N Rich, John H Sampson, James M Provenzale, Roger E McLendon, Sridharan Gururangan, Darell D Bigner, James E Herndon, Nicholas Avgeropoulos, Jonathan Finlay, Sandra Tourt-Uhlig, Mary Lou Affronti, Brandon Evans, Valerie Stafford-Fox, Sara Zaknoen, Henry S Friedman Phase II trial of temozolomide in patients with progressive low-grade glioma CONCLUSION: Initial results indicate that Temodar may be active in the treatment of low-grade glioma, and thus, further evaluation of this agent in the treatment of these tumors is warranted. 2/15/2003
Paul K Tulikangas, Diane S Robinson, Tommaso Falcone Left upper quadrant cannula insertion CONCLUSION(S): Primary left upper quadrant cannula insertion is a safe and effective alternative to primary umbilical cannula insertion. 2/6/2003
John L Francis, George J Palmer, Rebecca Moroose, Alane Drexler Comparison of bovine and porcine heparin in heparin antibody formation after cardiac surgery CONCLUSIONS: This study confirms the high frequency of heparin-PF4 antibodies after coronary artery bypass grafting and demonstrates a significantly higher incidence after bovine heparin. However, because some patients may seroconvert after discharge, our study may underestimate the true incidence. 1/23/2003
Jennifer F Tseng, Richard C Mulligan Gene therapy for pancreatic cancer Gene transfer technology has the potential to revolutionize cancer treatment. Developments in molecular biology, genetics, genomics, stem cell technology, virology, bioengineering, and immunology are accelerating the pace of innovation and movement from the laboratory bench to the clinical arena. Pa... 12/19/2002
Jennifer F Tseng, Filip A Farnebo, Oliver Kisker, Christian M Becker, Calvin J Kuo, Judah Folkman, Richard C Mulligan Adenovirus-mediated delivery of a soluble form of the VEGF receptor Flk1 delays the growth of murine and human pancreatic adenocarcinoma in mice CONCLUSION: A recombinant adenovirus encoding soluble Flk-1 inhibited pancreatic tumor growth in mice. These studies suggest that the delivery of gene products such as Flk1-Fc through in vivo gene transfer may be useful in the future treatment of patients with pancreatic cancer. 12/5/2002
Roy S Herbst, Kenneth R Hess, Hai T Tran, Jennifer E Tseng, Nizar A Mullani, Chusilp Charnsangavej, Timothy Madden, Darren W Davis, David J McConkey, Michael S O'Reilly, Lee M Ellis, James Pluda, Waun K Hong, James L Abbruzzese Phase I study of recombinant human endostatin in patients with advanced solid tumors CONCLUSION: rh-Endo was safe and well tolerated. rh-Endo pharmacokinetic profiles achieved area under the concentration-time curves associated with activity in preclinical models. Evidence of minor antitumor activity was observed and further studies are indicated. 9/14/2002
Michael J Hausmann, Daniel Landau A Down syndrome patient treated by peritoneal dialysis Down syndrome patients are apparently not suited for peritoneal dialysis because of lacking cooperation. We report on an adult Down syndrome patient living in a difficult social environment suffering from ESRD due to posterior urethral valve. Comorbid conditions include decreased left ventricular fu... 9/10/2002
Nannette Marr, Daniel G Bichet, Susan Hoefs, Paul J M Savelkoul, Irene B M Konings, Fabrizio De Mattia, Michael P J Graat, Marie-Françoise Arthus, Michele Lonergan, T Mary Fujiwara, Nine V A M Knoers, Daniel Landau, William J Balfe, Alexander Oksche, Walter Rosenthal, Dominik Müller, Carel H Van Os, Peter M T Deen Cell-biologic and functional analyses of five new Aquaporin-2 missense mutations that cause recessive nephrogenic diabetes insipidus Mutations in the Aquaporin-2 gene, which encodes a renal water channel, have been shown to cause autosomal nephrogenic diabetes insipidus (NDI), a disease in which the kidney is unable to concentrate urine in response to vasopressin. Most AQP2 missense mutants in recessive NDI are retained in the en... 8/23/2002
William R Tyor, Nicholas Avgeropoulos, George Ohlandt, Edward L Hogan Treatment of spinal cord impact injury in the rat with transforming growth factor-beta To investigate the contribution of cytokines, proinflammatory TNF-alpha and inhibitory TGF-beta, to spinal cord injury (SCI) in a rat model, two studies were performed using adult Sprague-Dawley rats which were injured at T9/T10. In the first study, rats were sacrificed at 1, 6, 24, 96 and 168 h aft... 7/20/2002
Roxanne Y Walder, Daniel Landau, Peter Meyer, Hanna Shalev, Maria Tsolia, Zvi Borochowitz, Melanie Barbara Boettger, Gretel E Beck, Richard K Englehardt, Rivka Carmi, Val C Sheffield Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia Familial hypomagnesemia with secondary hypocalcemia (OMIM 602014) is an autosomal recessive disease that results in electrolyte abnormalities shortly after birth. Affected individuals show severe hypomagnesemia and hypocalcemia, which lead to seizures and tetany. The disorder has been thought to be ... 5/29/2002
L J Herrera, H Lugo-Vicente Primary embryonal rhabdomyosarcoma of the breast in an adolescent female: a case report Rhabdomyosarcoma is the most common soft tissue sarcoma in children. Primary breast location has been reported rarely in the literature. Most rhabdomyosarcomas encountered in the breast more commonly are metastatic disease from some primary foci in another part of the body. This report addresses the... 11/5/1998