Journals and Research

Research and education are foundational to the mission of Orlando Health and our Cancer Institute. As frequent contributors to leading publications, our physicians share their research and clinical insights with a national and international community of colleagues.

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Author(s) Title Description Publish Date
Rahim Hirani, Kaleb Noruzi, Hassan Khuram, Anum S Hussaini, Esewi Iyobosa Aifuwa, Kencie E Ely, Joshua M Lewis, Ahmed E Gabr, Abbas Smiley, Raj K Tiwari, Mill Etienne Artificial Intelligence and Healthcare A Journey through History, Present Innovations, and Future Possibilities Artificial intelligence (AI) has emerged as a powerful tool in healthcare significantly impacting practices from diagnostics to treatment delivery and patient management. This article examines the progress of AI in healthcare, starting from the field's inception in the 1960s to present-day innovativ... 5/25/2024
Kelsey S Romatoski, Susanna W L de Geus, Bharath Miriyam, Sophie H Chung, Kelly Kenzik, Marianna V Papageorge, Gordana Rasic, Sing Chau Ng, Jennifer F Tseng, Teviah E Sachs Overall Volume of Upper Gastrointestinal Surgery Positively Impacts Gastric Cancer Outcomes at Centers with Low Gastrectomy Volume CONCLUSIONS: Despite lower gastrectomy volume for cancer, postoperative gastrectomy outcomes at centers that perform a high number of upper gastrointestinal cancer surgeries were similar to hospitals with high gastrectomy volume. These hospitals offer a blueprint for providing equivalent outcomes to... 5/22/2024
Veer S Sawhney, Priyanka V Chugh, Teviah E Sachs, Andrea Hayes Dixon, Valentine Nfonsam, Rabih Chaer, Carol Barry, Kelly Kenzik, Herbert Chen, Jennifer F Tseng Observations on the Representation of Asians in Surgical Training and Leadership CONCLUSIONS: In 5 years, Asians have made numeric gains in medical school and surgical training. However, Asian representation lags at Board examiner levels compared to the medical student population. The ABS has made recent efforts at transparency around examiner and examinee characteristics. A pil... 5/3/2024
Zhishan Chen, Xingyi Guo, Ran Tao, Jeroen R Huyghe, Philip J Law, Ceres Fernandez-Rozadilla, Jie Ping, Guochong Jia, Jirong Long, Chao Li, Quanhu Shen, Yuhan Xie, Maria N Timofeeva, Minta Thomas, Stephanie L Schmit, Virginia Díez-Obrero, Matthew Devall, Ferran Moratalla-Navarro, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah E W Briggs, Victoria Svinti, Kevin Donnelly, Susan M Farrington, James Blackmur, Peter G Vaughan-Shaw, Xiao-Ou Shu, Yingchang Lu, Peter Broderick, James Studd, Tabitha A Harrison, David V Conti, Fredrick R Schumacher, Marilena Melas, Gad Rennert, Mireia Obón-Santacana, Vicente Martín-Sánchez, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John L Hopper, Mark A Jenkins, Aung Ko Win, Rish K Pai, Jane C Figueiredo, Robert W Haile, Steven Gallinger, Michael O Woods, Polly A Newcomb, David Duggan, Jeremy P Cheadle, Richard Kaplan, Rachel Kerr, David Kerr, Iva Kirac, Jan Böhm, Jukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri A Aaltonen, Harri Rissanen, Eero Pukkala, Johan G Eriksson, Tatiana Cajuso, Ulrika Hänninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Satu Männistö, Demetrius Albanes, Stephanie J Weinstein, Edward Ruiz-Narvaez, Julie R Palmer, Daniel D Buchanan, Elizabeth A Platz, Kala Visvanathan, Cornelia M Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter T Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha L Slattery, John D Potter, Kostas K Tsilidis, Matthias B Schulze, Marc J Gunter, Neil Murphy, Antoni Castells, Sergi Castellví-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, D Timothy Bishop, Graham G Giles, Melissa C Southey, Gregory E Idos, Kevin J McDonnell, Zomoroda Abu-Ful, Joel K Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope O Keku, Bethany van Guelpen, Thomas J Hudson, Heather Hampel, Rachel Pearlman, Sonja I Berndt, Richard B Hayes, Marie Elena Martinez, Sushma S Thomas, Paul D P Pharoah, Susanna C Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly F Doheny, Elizabeth Pugh, Tameka Shelford, Andrew T Chan, Marcia Cruz-Correa, Annika Lindblom, David J Hunter, Amit D Joshi, Clemens Schafmayer, Peter C Scacheri, Anshul Kundaje, Robert E Schoen, Jochen Hampe, Zsofia K Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Christopher K Edlund, W James Gauderman, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen J Chanock, Franzel van Duijnhoven, Edith J M Feskens, Lori C Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Barbara Pardini, Liesel M FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie A Bien, Charles Kooperberg, Christopher I Li, Yi Lin, Ross Prentice, Conghui Qu, Stéphane Bézieau, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Loic Le Marchand, Anna H Wu, Chenxu Qu, Caroline E McNeil, Gerhard Coetzee, Caroline Hayward, Ian J Deary, Sarah E Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Ken S Lau, Hongyu Zhao, Li Hsu, Qiuyin Cai, Malcolm G Dunlop, Stephen B Gruber, Richard S Houlston, Victor Moreno, Graham Casey, Ulrike Peters, Ian Tomlinson, Wei Zheng Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 1... 4/26/2024
Gabrielle Marchelli, Candelaria Mercado, Corey S Gill, Harry K W Kim Pathogenic Gene Variants Identified in Patients Presenting With Perthes or Perthes-like Hip Disorder CONCLUSIONS: With 30% of the patients showing pathogenic results, genetic testing of select patients with Perthes-like disease is valuable in detecting an underlying genetic disorder or a carrier status of a genetic disorder. 4/23/2024
Mingjuan Li, Esmeralda D C Bosman, Olivia M Smith, Nicole Lintern, Daniel J de Klerk, Hong Sun, Shuqun Cheng, Weiwei Pan, Gert Storm, Yazan S Khaled, Michal Heger, Photodynamic Therapy Study Group Comparative analysis of whole cell-derived vesicular delivery systems for photodynamic therapy of extrahepatic cholangiocarcinoma This first-in-its-class proof-of-concept study explored the use of bionanovesicles for the delivery of photosensitizer into cultured cholangiocarcinoma cells and subsequent treatment by photodynamic therapy (PDT). Two types of bionanovesicles were prepared: cellular vesicles (CVs) were fabricated by... 4/12/2024
Christin Hoffmann, Kerry Avery, Rhiannon Macefield, Tadeáš Dvořák, Val Snelgrove, Jane Blazeby, Della Hopkins, Shireen Hickey, Ben Gibbison, Leila Rooshenas, Adam Williams, Jonathan Aning, Hilary L Bekker, Angus Gk McNair, ALPACA Study Team Usability of an Automated System for Real-Time Monitoring of Shared Decision-Making for Surgery Mixed Methods Evaluation CONCLUSIONS: A mixed methods evaluation of an electronic measurement system for automated, real-time monitoring of patients' experience of SDM showed that usability among patients was high. Future pilot work will optimize the system for wider implementation to ultimately inform intervention developm... 4/10/2024
Eleftherios A Makris, Thuy B Tran, Daniel J Delitto, Byrne Lee, Cecilia G Ethun, Valerie Grignol, J Harrison Howard, Meena Bedi, T Clark Gamblin, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Darren Cullinan, Ryan C Fields, Kenneth Cardona, George Poultsides, Amanda Kirane Natural history of undifferentiated pleomorphic sarcoma Experience from the US Sarcoma Collaborative CONCLUSION: For patients with resected extremity and truncal UPS, tumor size >5 cm and positive resection margin are associated with worse survival OS and RFS, irrespectively the site of origin. R0 surgical resection and radiation treatment may help improve these survival outcomes. 4/2/2024
Vidhya Prakash, Chinchu Bose, Damu Sunilkumar, Robin Mathew Cherian, Shwetha Susan Thomas, Bipin G Nair Resveratrol as a Promising Nutraceutical Implications in Gut Microbiota Modulation, Inflammatory Disorders, and Colorectal Cancer Natural products have been a long-standing source for exploring health-beneficial components from time immemorial. Modern science has had a renewed interest in natural-products-based drug discovery. The quest for new potential secondary metabolites or exploring enhanced activities for existing molec... 3/28/2024
Lucía Almorox, Laura Antequera, Ignacio Rojas, Luis Javier Herrera, Francisco M Ortuño Gene Expression Analysis for Uterine Cervix and Corpus Cancer Characterization The analysis of gene expression quantification data is a powerful and widely used approach in cancer research. This work provides new insights into the transcriptomic changes that occur in healthy uterine tissue compared to those in cancerous tissues and explores the differences associated with uter... 3/28/2024
Yazan S Khaled, M Ibrahim Khot, Radhika Aiyappa-Maudsley, Thomas Maisey, Arindam Pramanik, Jim Tiernan, Nicole Lintern, Eiman Al-Enezi, Shazana H Shamsuddin, Darren Tomlinson, Louise Coletta, Paul A Millner, Thomas A Hughes, David G Jayne Photoactive imaging and therapy for colorectal cancer using a CEA-Affimer conjugated Foslip nanoparticle Theranostic nanoparticles hold promise for simultaneous imaging and therapy in colorectal cancer. Carcinoembryonic antigen can be used as a target for these nanoparticles because it is overexpressed in most colorectal cancers. Affimer reagents are synthetic proteins capable of binding specific targe... 3/20/2024
Vincent S Alexander, Michael Ernst, Wang L Cheung, Alyssa N Obermiller, Catherine Mercado, Hermes Garcia, Kavita M Pattani High-Grade Atypical TeratoidRhabdoid Tumor in the Pituitary Region Atypical teratoid/rhabdoid tumors (AT/RTs) are embryological tumors of the central nervous system (CNS). They are typically found in children, with rare presentations in adults. We describe the presentation of an AT/RT in the pituitary region of a 37-year-old female. The patient presented with a two... 3/15/2024
Madeleine L French, Joshua T Christensen, Paul A Estabrooks, Alexandra M Hernandez, Julie M Metos, Robin L Marcus, Alistair Thorpe, Theresa E Dvorak, Kristine C Jordan Evaluation of the Effectiveness of a Bilingual Nutrition Education Program in Partnership with a Mobile Health Unit There are limited reports of community-based nutrition education with culinary instruction that measure biomarkers, particularly in low-income and underrepresented minority populations. Teaching kitchens have been proposed as a strategy to address social determinants of health, combining nutrition e... 3/13/2024
Naziya Samreen, Cecilia Mercado, Laura Heacock, Celin Chacko, Savannah C Partridge, Chloe Chhor Screening Breast MRI Primer Indications, Current Protocols, and Emerging Techniques Breast dynamic contrast-enhanced MRI (DCE-MRI) is the most sensitive imaging modality for the detection of breast cancer. Screening MRI is currently performed predominantly in patients at high risk for breast cancer, but it could be of benefit in patients at intermediate risk for breast cancer and p... 3/1/2024
Cecilia Mercado, Chloe Chhor, John R Scheel MRI in the Setting of Neoadjuvant Treatment of Breast Cancer Neoadjuvant therapy may reduce tumor burden preoperatively, allowing breast conservation treatment for tumors previously unresectable or requiring mastectomy without reducing disease-free survival. Oncologists can also use the response of the tumor to neoadjuvant chemotherapy (NAC) to identify treat... 2/29/2024
Rachel Miceli, Cecilia L Mercado, Osvaldo Hernandez, Chloe Chhor Active Surveillance for Atypical Ductal Hyperplasia and Ductal Carcinoma In Situ Atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS) are relatively common breast lesions on the same spectrum of disease. Atypical ductal hyperblasia is a nonmalignant, high-risk lesion, and DCIS is a noninvasive malignancy. While a benefit of screening mammography is early cancer ... 2/28/2024
Mousa Thalji, Vamshi Vadlapatla, Nicholas G Avgeropoulos, Naren Ramakrishna, Said Baidas Exceptional and Sustained Response to Belzutifan in Von Hippel-Lindau Disease-Associated Central Nervous System Hemangioblastoma Von Hippiel-Lindau (VHL) disease is a rare genetic disorder characterized by a variety of benign and malignant neoplastic growths arising in multiple different organ systems. About 60%-84% of patients develop hemangioblastomas, benign tumors comprised of newly formed blood vessels that often occur i... 2/26/2024
Z Adamová, M Chrostek, T Dvořák, E Rada Duodenal gastrinoma - case report CONCLUSION: With this case report, we want to emphasize the importance of taking into account neuroendocrine tumors in our differential diagnostic considerations. At the same time, we want to highlight that, according to ESMO recommendations, we should preferentially use 68Ga-DOTATOC PET/CT for the ... 2/20/2024
Robert VanBuren, Annie Nguyen, Rose A Marks, Catherine Mercado, Anna Pardo, Jeremy Pardo, Jenny Schuster, Brian St Aubin, Mckena Lipham Wilson, Seung Y Rhee Variability in drought gene expression datasets highlight the need for community standardization Physiologically relevant drought stress is difficult to apply consistently, and the heterogeneity in experimental design, growth conditions, and sampling schemes make it challenging to compare water deficit studies in plants. Here, we re-analyzed hundreds of drought gene expression experiments acros... 2/19/2024
Yashwant Patidar, Kartik Mittal, Ranjan Kumar Patel, Sherin Sarah Thomas, Shiv Kumar Sarin Liver volumetry in cirrhotic patients with or without hepatocellular carcinoma Its correlation with Child-Pugh, model for end-stage liver diseases and indocyanine green dye test CONCLUSION: NTLV showed a significant negative correlation with ICG-r15% in cirrhotic patients with HCC, but not in cirrhotic patients without HCC. Therefore, CT volumetry can be a valuable tool to predict the functional hepatic volume in patients of cirrhosis with HCC subjected for hepatectomy, whe... 2/13/2024
Amanda H Seekings, Yuan Liang, Caroline J Warren, Charlotte K Hjulsager, Saumya S Thomas, Fabian Z X Lean, Alejandro Nunez, Paul Skinner, David Selden, Marco Falchieri, Hugh Simmons, Ian H Brown, Lars E Larsen, Ashley C Banyard, Marek J Slomka Transmission dynamics and pathogenesis differ between pheasants and partridges infected with clade 2344b H5N8 and H5N1 high-pathogenicity avian influenza viruses During the UK 2020-2021 epizootic of H5Nx clade 2.3.4.4b high-pathogenicity avian influenza viruses (HPAIVs), high mortality occurred during incursions in commercially farmed common pheasants (Phasianus colchicus). Two pheasant farms, affected separately by H5N8 and H5N1 subtypes, included adjacentl... 1/30/2024
Jia Song, Jiao Wu, Dexter J Robichaux, Tingting Li, Shuyue Wang, Maria J Arredondo Sancristobal, Bingning Dong, Dobromir Dobrev, Jason Karch, Sandhya S Thomas, Na Li A High-Protein Diet Promotes Atrial Arrhythmogenesis via Absent-in-Melanoma 2 Inflammasome High-protein diets (HPDs) offer health benefits, such as weight management and improved metabolic profiles. The effects of HPD on cardiac arrhythmogenesis remain unclear. Atrial fibrillation (AF), the most common arrhythmia, is associated with inflammasome activation. The role of the Absent-in-Melan... 1/22/2024
Sophie H Chung, Gordana Rasic, Kelsey S Romatoski, Kelly Kenzik, Jennifer F Tseng, Teviah E Sachs Disparate impact of the COVID-19 pandemic on delays in colorectal cancer treatment A National Cancer Database study CONCLUSION: Although the pandemic did not delay treatment for colorectal cancer overall, vulnerable and underserved populations were disproportionately affected by delays to all forms of therapy. The difference in colorectal cancer outcomes in the coming years as a result of delays in treatment may ... 1/20/2024
Isabelle Meulenbroeks, Crisostomo Mercado, Peter Gates, Amy Nguyen, Karla Seaman, Nasir Wabe, Sandun M Silva, Wu Yi Zheng, Deborah Debono, Johanna Westbrook Effectiveness of fall prevention interventions in residential aged care and community settings an umbrella review CONCLUSION: 'Exercise' interventions may be the most appropriate falls prevention intervention for older adults in RAC and community settings as it is beneficial for multiple fall-related outcomes (falls, fall-related fractures, and people who have had a fall). Augmenting 'exercise' interventions to... 1/19/2024
Ilaria Crespiatico, Mattia Zaghi, Cristina Mastini, Deborah D'Aliberti, Mario Mauri, Carl Mirko Mercado, Diletta Fontana, Silvia Spinelli, Valentina Crippa, Elena Inzoli, Beatrice Manghisi, Ivan Civettini, Daniele Ramazzotti, Valentina Sangiorgio, Michele Gengotti, Virginia Brambilla, Andrea Aroldi, Federica Banfi, Cristiana Barone, Roberto Orsenigo, Ludovica Riera, Mara Riminucci, Alessandro Corsi, Massimo Breccia, Alessandro Morotti, Daniela Cilloni, Aldo Roccaro, Antonio Sacco, Fabio Stagno, Marta Serafini, Federica Mottadelli, Giovanni Cazzaniga, Fabio Pagni, Roberto Chiarle, Emanuele Azzoni, Alessandro Sessa, Carlo Gambacorti-Passerini, Elena Maria Elli, Luca Mologni, Rocco Piazza First-hit SETBP1 mutations cause a myeloproliferative disorder with bone marrow fibrosis SETBP1 mutations are found in various clonal myeloid disorders. However, it is unclear whether they can initiate leukemia, because SETBP1 mutations typically appear as later events during oncogenesis. To answer this question, we generated a mouse model expressing mutated SETBP1 in hematopoietic tiss... 1/9/2024
Mahbuba Choudhury, Sharon Shibu Thomas, Alexander Cain, Sreekanth Palvai, Saiji Nageshwaran, Jufen Zhang, Karen Hayden, Alexander Cain, Peter Hoskin, Imtiaz Ahmed Timing of High-Dose-Rate Brachytherapy With External Beam Radiation Therapy in Patients With Intermediate- and High-Risk Localized Prostate Cancer and Its Effects on Toxicity and Quality of Life A Randomized Controlled Trial THEPCA CONCLUSIONS: The sequencing of HDR-BT and EBRT did not affect the incidence of G3 or G4 toxicities, and no significant differences were seen in other patient-reported outcomes. Treatment was well tolerated with maintained QOL scores. Treatment failure was low in both arms in a high-risk cohort; howe... 1/1/2024
Amy I Laughlin, Quy Cao, Richard Bryson, Virginia Haughey, Rashad Abdul-Salaam, Virgilio Gonzenbach, Mridini Rudraraju, Igor Eydman, Christopher M Tweed, Glenn J Fala, Kash Patel, Kevin R Fox, C William Hanson, Justin E Bekelman, Haochang Shou Detection of Medication Taking Using a Wrist-Worn Commercially Available Wearable Device CONCLUSION: These results in a patient-specific population are exemplar of the potential to measure real-time medication adherence using a wrist-worn commercially available wearable device. 12/21/2023
Ashlee N Seldomridge, Gordana Rasic, Marianna V Papageorge, Sing Chau Ng, Susanna W L de Geus, Alison P Woods, David McAneny, Jennifer F Tseng, Teviah E Sachs Trends in access to minimally invasive pancreaticoduodenectomy for pancreatic cancers CONCLUSION: SDH predict surgical approach more than clinical stage, facility type, or comorbidity status. Disparities in race and insurance coverage are different between surgical approaches. 12/13/2023
Hadi Kaseb Ghane, Nazanin Samiei, Pouyan Razavi, Yasser Khaled, Reza Fekrazad High-Power Laser Application for Immediate Implant Placement in Infected Sites A Systematic Review Objective: The purpose of this study was to review the literatures regarding the treatment outcomes of applying laser to the infected sites in immediate implant placement. The review tended to primarily target a question: does applying high-power laser have any positive effect on infected sites in i... 12/12/2023
Herbert Lepor, Lucas Wiegand, Kalpesh Patel, Wei Du, Suzanne Gagnon, 19IC01 Investigators A Randomized Clinical Trial Evaluating Indigo Carmine as a Visualization Aid for Evaluating Ureteral Patency CONCLUSION: Both dose levels of indigo carmine were significantly better than saline as a visualization aid for ureter patency. 12/7/2023
Sage J Kim, Caroline Kery, Jinghua An, James Rineer, Georgiy Bobashev, Alicia K Matthews RacialEthnic disparities in exposure to neighborhood violence and lung cancer risk in Chicago CONCLUSIONS: Neighborhood violence was associated with an increased risk of lung cancer. Black residents in Chicago are disproportionately exposed to neighborhood violence, which may partially explain the existing racial disparity in lung cancer. Incorporating neighborhood violence exposure into lun... 12/3/2023
Tomáš Dvořák, Michal Knapp Conserved temperature requirements but contrasting responses to humidity across oviposition preferences in temperate grasshoppers The right choice of an oviposition site is a crucial task for oviparous species without maternal care. In contrast to well investigated biotic factors, e.g., larval food preferences, parasitism, predation, and competition avoiding, abiotic factors affecting oviposition preferences in insects have be... 11/30/2023
Brendin R Beaulieu-Jones, Emily J Ha, Ann Fefferman, Judy Wang, Sophie H Chung, Jennifer F Tseng, Andrea Merrill, Teviah E Sachs, Naomi Y Ko, Michael R Cassidy Association of Race, Ethnicity, Language, and Insurance with Time to Treatment Initiation Among Women with Breast Cancer at an Urban, Academic, Safety-Net Hospital CONCLUSION: At our institution, race, ethnicity, insurance, and language were not associated with treatment delay. Additional research is needed to determine how our safety-net hospital delivered timely care to all patients with breast cancer, as reducing delays in care may be one mechanism by which... 11/28/2023
Rahim Hirani, Kaleb Noruzi, Aroubah Iqbal, Anum S Hussaini, Rafay A Khan, Aleksandr Harutyunyan, Mill Etienne, Raj K Tiwari A Review of the Past, Present, and Future of the Monkeypox Virus Challenges, Opportunities, and Lessons from COVID-19 for Global Health Security Monkeypox, a rare but significant zoonotic and orthopoxviral disease, has garnered increasing attention due to its potential for human-to-human transmission and its recent resurgence in multiple countries throughout Europe, North America, and Oceania. The disease has emerged as a novel threat to the... 11/25/2023
Sergio Ortiz, Ignacio Rojas-Valenzuela, Fernando Rojas, Olga Valenzuela, Luis Javier Herrera, Ignacio Rojas Novel methodology for detecting and localizing cancer area in histopathological images based on overlapping patches Cancer disease is one of the most important pathologies in the world, as it causes the death of millions of people, and the cure of this disease is limited in most cases. Rapid spread is one of the most important features of this disease, so many efforts are focused on its early-stage detection and ... 11/24/2023
Arjen Tilstra, Lorena Braxator, Bianca Thobor, Selma D Mezger, Claudia E L Hill, Yusuf C El-Khaled, Giulia Caporale, Sohyoung Kim, Christian Wild Short-term ocean acidification decreases pulsation and growth of the widespread soft coral Xenia umbellata Coral reefs may experience lower pH values as a result of ocean acidification (OA), which has negative consequences, particularly for calcifying organisms. Thus far, the effects of this global factor have been mainly investigated on hard corals, while the effects on soft corals remain relatively und... 11/15/2023
Meijun Si, Rizhen Yu, Hongchun Lin, Feng Li, Sungyun Jung, Sandhya S Thomas, Farhard S Danesh, Yanlin Wang, Hui Peng, Zhaoyong Hu ROCK1 activates mitochondrial fission leading to oxidative stress and muscle atrophy Chronic kidney disease (CKD) is often associated with protein-energy wasting (PEW), which is characterized by a reduction in muscle mass and strength. Although mitochondrial dysfunction and oxidative stress have been implicated to play a role in the pathogenesis of muscle wasting, the underlying mec... 10/31/2023
Supriya Sen, Shawn Sam Thomas, Anish Cherian, Deepak Abraham, Julie Hepzhibah, Reetu John, Marie Therese, K Reka, M J Paul Thyroglossal Duct Cyst Carcinoma Lessons from a 20-Case Series CONCLUSIONS: TDCC is rare and a disease of young adulthood and usually has good prognosis. It may be a clinical surprise or a small lesion which can be detected with ultrasound and targeted FNAC. There is high rate of concomitant thyroid carcinoma and hence needs careful assessment. Sistrunk's proce... 10/30/2023
Maria Tejada-Casado, María M Pérez, Alvaro Della Bona, Henning Lübbe, Razvan Ghinea, Luis Javier Herrera Chroma-dependence of CIEDE2000 acceptability thresholds for dentistry CONCLUSIONS: 50:50% CIEDE2000 acceptability thresholds for dentistry are significantly different depending on the chromaticity of the samples. Observers show higher acceptability for more achromatic samples (low chroma value) than for more chromatic samples. 10/20/2023
Hongchun Lin, Hui Peng, Yuxiang Sun, Meijun Si, Jiao Wu, Yanlin Wang, Sandhya S Thomas, Zheng Sun, Zhaoyong Hu Reprogramming of cis-regulatory networks during skeletal muscle atrophy in male mice A comprehensive atlas of cis-regulatory elements and their dynamic activity is necessary to understand the transcriptional basis of cellular structure maintenance, metabolism, and responses to the environment. Here we show, using matched single-nucleus chromatin accessibility and RNA-sequencing from... 10/18/2023
Britta Retzlaff Brennan, Katherine A Beals, Ryan D Burns, Candace J Chow, Amy B Locke, Margaret P Petzold, Theresa E Dvorak Impact of Culinary Medicine Course on Confidence and Competence in Diet and Lifestyle Counseling, Interprofessional Communication, and Health Behaviors and Advocacy Most physicians report inadequate training to provide diet and lifestyle counseling to patients despite its importance to chronic disease prevention and management. To fill the nutrition training gap, elective Culinary Medicine (CM) courses have emerged as an alternative to curriculum reform. We eva... 10/14/2023
Lucas R Wiegand, Thanh Q Tran, Kevin Heinsimer, Bhavik Shah Safety of Xiaflex Collagenase Clostridium histolyticum Treatment for Adult Anterior Urethral Stricture Disease Male urethral stricture disease is highly prevalent and difficult to treat due to potential complications. Minimally invasive treatments tend to have high recurrence rates, keeping urethroplasty as the gold standard. Collagenase Clostridium histolyticum (CCH) has been used in humans to treat fibrosi... 10/13/2023
Tomáš Dvořák, Jörg Bohlen, Maurice Kottelat, Vendula lechtová Revision of the Schistura cincticauda species group Teleostei, Nemacheilidae using molecular and morphological markers To approach the taxonomy of large and complex animal groups it is of advantage to focus on species groups with shared derived character state. We investigate the composition, morphological characteristics and relationships of and within the Schistura cincticauda species group, whose members are smal... 10/9/2023
Victoria Panagiota, Johanna Franziska Kerschbaum, Olaf Penack, Catarina M Stein, Christopher M Arends, Christian Koenecke, Paulina M Strzelecka, Arnold Kloos, Laura Wiegand, Alina Lasch, Robert Altwasser, Adriane Halik, Razif Gabdoulline, Julia Thomson, Konstantin Weibl, Georg-Nikolaus Franke, Carolina Berger, Justin Hasenkamp, Francis Ayuk, Il-Kang Na, Gernot Beutel, Ulrich Keller, Lars Bullinger, Gerald Georg Wulf, Nicolaus Kröger, Vladan Vucinic, Michael Heuser, Frederik Damm Clinical Implications and Dynamics of Clonal Hematopoiesis in Anti-CD19 CAR T-cell Treated Patients Recent evidence revealed important interactions between clonal hematopoiesis (CH) and cellular therapies established for the treatment of hematologic malignancies. The impact of CH on safety, efficacy, and outcome of chimeric antigen receptor (CAR) T-cell therapy is currently under investigation. We... 10/6/2023
Vishnu P Parvathareddy, Jiao Wu, Sandhya S Thomas Insulin Resistance and Insulin Handling in Chronic Kidney Disease Insulin regulates energy metabolism involving multiple organ systems. Insulin resistance (IR) occurs when organs exhibit reduced insulin sensitivity, leading to difficulties in maintaining glucose homeostasis. IR ensures decades prior to development of overt diabetes and can cause silent metabolic d... 9/28/2023
Amanda H Seekings, Caroline J Warren, Saumya S Thomas, Fabian Z X Lean, David Selden, Benjamin C Mollett, Pauline M van Diemen, Ashley C Banyard, Marek J Slomka Different Outcomes of Chicken Infection with UK-Origin H5N1-2020 and H5N8-2020 High-Pathogenicity Avian Influenza Viruses Clade 2344b Clade 2.3.4.4 H5Nx highly pathogenic avian influenza viruses (HPAIVs) of the "goose/Guangdong" lineage have caused a series of European epizootics since 2014. During autumn/winter 2020-2021, several H5Nx subtypes were detected in the UK, with H5N8 being the dominant subtype in wild birds and poultry... 9/28/2023
Daniel S Oh, Marzieh Ershad, Jon O Wee, Manu Suraj Sancheti, Desmond M D'Souza, Luis Javier Herrera, Lana Y Schumacher, Mallory Shields, Kristen Brown, Sadia Yousaf, John F Lazar Comparison of Global Evaluative Assessment of Robotic Surgery with objective performance indicators for the assessment of skill during robotic-assisted thoracic surgery CONCLUSION: There was a relatively poor overall correlation between the Global Evaluative Assessment of Robotic Skills and objective performance indicators. However, both appear strongly correlated for certain metrics such as efficiency and smoothness. Objective performance indicators may be a poten... 9/17/2023
Kavita Jain, Archana Rastogi, Sherin S Thomas, Chhagan Bihari Autoantibody Positivity Has No Impact on Histological Parameters in Nonalcoholic Fatty Liver Diseases CONCLUSIONS: Autoantibodies noted in 41% NAFLD cases. No significant necroinflammatory activity or fibrosis associated with presence of antibodies in NAFLD cases. However, CK-18-M30 showed a rising trend from NAFL to NASH to NASH + AIH. 9/11/2023
Laura Goyack, Gurjot Garcha, Ruchir Shah, Yahaira Ortiz Gonzalez, Mark Vollenweider, Mohammad Salimian, Wang Cheung Rapid effect of benralizumab in fulminant eosinophilic myocarditis in the setting of uncontrolled eosinophilic asthma A 51-year-old male with uncontrolled asthma and recent convalescence from severe acute respiratory syndrome coronavirus-2c pneumonia presented with cough, dyspnea, and chest pain. Evaluation revealed significant peripheral eosinophilia, elevated troponin, and biventricular failure resulting in cardi... 9/6/2023
Francisco Carrillo-Perez, Marija Pizurica, Michael G Ozawa, Hannes Vogel, Robert B West, Christina S Kong, Luis Javier Herrera, Jeanne Shen, Olivier Gevaert Synthetic whole-slide image tile generation with gene expression profile-infused deep generative models In this work, we propose an approach to generate whole-slide image (WSI) tiles by using deep generative models infused with matched gene expression profiles. First, we train a variational autoencoder (VAE) that learns a latent, lower-dimensional representation of multi-tissue gene expression profile... 9/6/2023
C E L Hill, S G Abbass, G Caporale, Y C El-Khaled, L Kuhn, T Schlenzig, C Wild, A Tilstra Physiology of the widespread pulsating soft coral emXenia umbellataem is affected by food sources, but not by water flow Coral energy and nutrient acquisition strategies are complex and sensitive to environmental conditions such as water flow. While high water flow can enhance feeding in hard corals, knowledge about the effects of water flow on the feeding of soft corals, particularly those pulsating, is still limited... 9/4/2023
Thomas Kozar, John Michael Kaylor, Cynthia Hinderscheid, Jamee Schoephoerster, Albert E Holler, Edward J Wright, Joseph J Pariser, William Boysen, Lucas Wiegand, J Patrick Selph, Andrew J Cohen Retrospective Multicenter Observational Study of Immediate Voiding at End of Urinary Sphincter Surgery REMOVE CONCLUSIONS: In our multi-institutional cohort, overall retention rates were low (7%) in groups with a catheter and without. Obviating postoperative catheterization facilitates outpatient incontinence surgery without altering reoperation over medium-term follow-up. 8/31/2023
Shreya P Ramkumar, Arun Bhardwaj, Amila Patel, Krishnamoorthy Seetharaman, Amanda Christman, Ninad Amondikar, Dina K Abouelella, Adnan S Hussaini, Justin M Barnes, Eric Adjei Boakye, Tammara L Watts, Nosayaba Osazuwa-Peters Differences in Receipt of Immunotherapy Treatment Among Patients With Head and Neck Cancer CONCLUSIONS AND RELEVANCE: The findings of this cohort study suggest that among older patients with HNSCC, White patients may be more likely to receive immunotherapy as part of their care. Equitable access to immunotherapy and other treatment options will reduce cancer-related health disparities and... 8/31/2023
Franziska Briest, Daniel Noerenberg, Cornelius Hennch, Kenichi Yoshida, Raphael Hablesreiter, Jose Nimo, Daniel Sasca, Marieluise Kirchner, Larry Mansouri, Yoshikage Inoue, Laura Wiegand, Annette M Staiger, Beatrice Casadei, Penelope Korkolopoulou, January Weiner, Armando Lopez-Guillermo, Arne Warth, Tamás Schneider, Ákos Nagy, Wolfram Klapper, Michael Hummel, George Kanellis, Ioannis Anagnostopoulos, Philipp Mertins, Lars Bullinger, Richard Rosenquist, Theodoros P Vassilakopoulos, German Ott, Seishi Ogawa, Frederik Damm Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma Recent exome-wide studies discovered frequent somatic mutations in the epigenetic modifier ZNF217 in primary mediastinal B cell lymphoma (PMBCL) and related disorders. As functional consequences of ZNF217 alterations remain unknown, we comprehensively evaluated their impact in PMBCL. Targeted sequen... 8/30/2023
Fabiola Rojas, Rodrigo Aguilar, Sandra Almeida, Elsa Fritz, Daniela Corvalán, Estibaliz Ampuero, Sebastián Abarzúa, Polett Garcés, Armando Amaro, Iván Diaz, Cristian Arredondo, Nicole Cortes, Mario Sanchez, Constanza Mercado, Lorena Varela-Nallar, Fen-Biao Gao, Martin Montecino, Brigitte van Zundert Mature iPSC-derived astrocytes of an ALSFTD patient carrying the TDP43supemA90Vemsup mutation display a mild reactive state and release polyP toxic to motoneurons Astrocytes play a critical role in the maintenance of a healthy central nervous system and astrocyte dysfunction has been implicated in various neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). There is compelling evidence that mouse and hu... 8/30/2023
Nicole Lintern, Andrew M Smith, David G Jayne, Yazan S Khaled Photodynamic Stromal Depletion in Pancreatic Ductal Adenocarcinoma Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid malignancies, with a five-year survival of less than 10%. The resistance of the disease and the associated lack of therapeutic response is attributed primarily to its dense, fibrotic stroma, which acts as a barrier to drug perfusi... 8/26/2023
Scott M Reid, Paul Skinner, David Sutton, Craig S Ross, Karolina Drewek, Natalia Weremczuk, Ashley C Banyard, Sahar Mahmood, Karen L Mansfield, Jo Mayers, Saumya S Thomas, Sharon M Brookes, Ian H Brown Understanding the disease and economic impact of avirulent avian paramyxovirus type 1 APMV-1 infection in Great Britain Newcastle disease (ND) is a notifiable disease affecting chickens and other avian species caused by virulent strains of Avian paramyxovirus type 1 (APMV-1). While outbreaks of ND can have devastating consequences, avirulent strains of APMV-1 generally cause subclinical infections or mild disease. Ho... 8/25/2023
Santhosh Raja Thangaraj, Mirra Srinivasan, Hadia Arzoun, Siji S Thomas A Systematic Review of the Emerging Treatment for Hepatorenal Syndrome With a Principal Focus on Terlipressin A Recent FDA-Approved Drug CONCLUSION: Terlipressin, one of the most widely used vasoconstrictor agents across the world, seems to be effective in reversing renal failure in HRS. Although adverse effects are seen with this agent, it is still beneficial when compared to other medications. Further studies with larger sample si... 8/25/2023
Michael Azzopardi, Tom Wallace, Yazan S Khaled Aortoiliac graft-enteric fistula presenting as gastrointestinal hemorrhage A report on a complex case management KEY CLINICAL MESSAGE: Iliac artery-enteric fistula is a rare cause of lower GI bleeding and can cause life-threatening consequences. A high degree of clinical suspicion is needed in patients with previous aortic surgery to allow early multidisciplinary intervention. 8/18/2023
Ricky Kristan M Raguindin, Candy C Mercado Localized surface plasmon resonance shift of biosynthesized and functionalized quasi-spherical gold nanoparticle systems Rapid and more environment-friendly means of gold nanoparticle synthesis is necessary in many applications, as in ion detection. Leaf extracts have become effective and economical reducing agents for gold nanoparticle formation, however, effects of extract combinations have not been thoroughly inves... 8/16/2023
Jia Song, Jose Alberto Navarro-Garcia, Jiao Wu, Arnela Saljic, Issam Abu-Taha, Luge Li, Satadru K Lahiri, Joshua A Keefe, Yuriana Aguilar-Sanchez, Oliver M Moore, Yue Yuan, Xiaolei Wang, Markus Kamler, William E Mitch, Gema Ruiz-Hurtado, Zhaoyong Hu, Sandhya S Thomas, Dobromir Dobrev, Xander Ht Wehrens, Na Li Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation Chronic kidney disease (CKD) is associated with a higher risk of atrial fibrillation (AF). The mechanistic link between CKD and AF remains elusive. IL-1β, a main effector of NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation, is a key modulator of conditions associated with inflamm... 8/15/2023
Jennifer F Tseng The 2023 A Hamblin Letton Lecture, Southeastern Surgical Conference Lecture Choices Matter in Cancer Surgery A Lifes Journey Attaining a successful career in cancer surgery depends on many choices. In this paper based on the Letton Lecture from the 2023 Southeastern Surgical Conference, Dr. Jennifer Tseng reflects on the choices that enabled her current work. 8/7/2023
Sophie H Chung, Kelsey S Romatoski, Gordana Rasic, Brendin R Beaulieu-Jones, Kelly Kenzik, Andrea L Merrill, Jennifer F Tseng, Michael R Cassidy, Teviah E Sachs Impact of the COVID-19 Pandemic on Delays to Breast Cancer Surgery Ripples or Waves CONCLUSION: The COVID-19 pandemic was associated with significant DTS for breast cancer but spared time to systemic therapy. Delays disproportionately impacted vulnerable and underserved patient populations. The true clinical effects of these delays may yet be realized for breast cancer patients. 8/1/2023
Marianna V Papageorge, Susanna W L de Geus, Alison P Woods, Sing Chau Ng, David McAneny, Jennifer F Tseng, Kelly M Kenzik, Teviah E Sachs The Evaluation of Gallstone Disease in the Year Before Pancreatic Cancer Diagnosis CONCLUSIONS: In the year before PDAC diagnosis, patients present with gallstone disease more often than the general population. Improving follow-up care and differential diagnosis strategies may help combat the high mortality rate in PDAC by providing an opportunity for earlier stage of diagnosis an... 7/23/2023
Jennifer F Tseng 2023 A Hamblin Letton Lecture For this lecture, I was inspired by Dr. Bryan Richmond's Southeastern Surgical Congress presidential address, "Finding your own unique place in the house of surgery." I struggled to find my own place in cancer surgery. The choices available to me and those who came before me enabled the wonderful ca... 7/12/2023
Edilson F Arruda, Rodrigo E A Alexandre, Marcelo D Fragoso, João B R do Val, Sinnu S Thomas A novel queue-based stochastic epidemic model with adaptive stabilising control The main objective of this paper is to propose a novel SEIR stochastic epidemic model. A distinguishing feature of this new model is that it allows us to consider a setup under general latency and infectious period distributions. To some extent, queuing systems with infinitely many servers and a Mar... 7/9/2023
Francisco Carrillo-Perez, Francisco M Ortuno, Alejandro Börjesson, Ignacio Rojas, Luis Javier Herrera Performance comparison between multi-center histopathology datasets of a weakly-supervised deep learning model for pancreatic ductal adenocarcinoma detection CONCLUSIONS: The integration of datasets where both classes are present can mitigate the batch effect present when integrating datasets, improving the classification performance, and accurately detecting PDAC across different datasets. 6/26/2023
Alexander M P Byrne, Joe James, Benjamin C Mollett, Stephanie M Meyer, Thomas Lewis, Magdalena Czepiel, Amanda H Seekings, Sahar Mahmood, Saumya S Thomas, Craig S Ross, Dominic J F Byrne, Michael J McMenamy, Valerie Bailie, Ken Lemon, Rowena D E Hansen, Marco Falchieri, Nicola S Lewis, Scott M Reid, Ian H Brown, Ashley C Banyard Investigating the Genetic Diversity of H5 Avian Influenza Viruses in the United Kingdom from 2020-2022 Since 2020, the United Kingdom and Europe have experienced annual epizootics of high-pathogenicity avian influenza virus (HPAIV). The first epizootic, during the autumn/winter of 2020-2021, involved six H5Nx subtypes, although H5N8 HPAIV dominated in the United Kingdom. While genetic assessments of ... 6/26/2023
Thomas J Herzog, John L Hays, Joyce N Barlin, Joseph Buscema, Noelle G Cloven, Lynn R Kong, Nidhi Kumar Tyagi, Grainger S Lanneau, Beverly J Long, Robert L Marsh, Shelly M Seward, David C Starks, Stephen Welch, Kathleen N Moore, Panagiotis A Konstantinopoulos, Lucy Gilbert, Bradley J Monk, David M O'Malley, Xiwei Chen, Rita Dalal, Robert L Coleman, Jalid Sehouli ARTISTRY-7 phase III trial of nemvaleukin alfa plus pembrolizumab vs chemotherapy for platinum-resistant ovarian cancer Standard single-agent nonplatinum chemotherapy provides only modest benefit in a small proportion of patients with platinum-resistant/-refractory ovarian cancer, with objective response rates of 6-20% and progression-free survival of ≈3-4 months. Nemvaleukin alfa (nemvaleukin, ALKS 4230) is a novel ... 6/19/2023
Yousef Khaled, Aya A Abdelhamid, Hissa Al-Mazroey, Abdulrahman K Almannai, Sara Fetais, Aisha S Al-Srami, Shaima Ahmed, Noora Al-Hajri, Ayman Mustafa, Tawanda Chivese, Laiche Djouhri Higher serum uric acid is associated with poorer cognitive performance in healthy middle-aged people a cross-sectional study Age-related cognitive impairment can occur many years before the onset of the clinical symptoms of dementia. Uric acid (UA), a metabolite of purine-rich foods, has been shown to be positively associated with improved cognitive function, but such association remains controversial. Moreover, most of t... 6/17/2023
Jennifer Tseng, Jose G Bazan, Christina A Minami, Mara A Schonberg Not Too Little, Not Too Much Optimizing More Versus Less Locoregional Treatment for Older Patients With Breast Cancer Although undertreatment of older women with aggressive breast cancers has been a concern for years, there is increasing recognition that some older women are overtreated, receiving therapies unlikely to improve survival or reduce morbidity. De-escalation of surgery may include breast-conserving surg... 6/16/2023
Kelsey S Romatoski, Sophie H Chung, Susanna W L de Geus, Marianna V Papageorge, Alison P Woods, Gordana Rasic, Sing Chau Ng, Jennifer F Tseng, Teviah E Sachs Combined High-Volume Common Complex Cancer Operations Safeguard Long-Term Survival in a Low-Volume Individual Cancer Operation Setting CONCLUSIONS: MVH hospitals performing sufficient complex common cancer operations demonstrate similar long-term survival for specific high-risk cancer operations to HVH. MVH provide an adjunctive model to the centralization of complex cancer surgery, while maintaining quality and access. 6/13/2023
Kelsey S Romatoski, Sophie H Chung, Kelly Kenzik, Gordana Rasic, Sing Chau Ng, Jennifer F Tseng, Teviah E Sachs Delay and Disparity in Observed vs Predicted Incidence Rate of Screenable Cancer During the COVID-19 Pandemic CONCLUSIONS: The reported incidence of screenable cancers significantly decreased during the COVID-19 pandemic (2020), suggesting that many patients currently harbor undiagnosed cancers. In addition to the human toll, this will further burden the healthcare system and increase future healthcare cost... 5/25/2023
John Robert C Medina, Rie Takeuchi, Chris Erwin G Mercado, Calvin S de Los Reyes, Rolando V Cruz, Melvin D R Abrigo, Paul Michael R Hernandez, Fernando B Garcia, Mika Salanguit, Ernesto R Gregorio, Shin'ya Kawamura, Khew Ee Hung, Masami Kaneko, Daisuke Nonaka, Richard J Maude, Jun Kobayashi Spatial and temporal distribution of reported dengue cases and hot spot identification in Quezon City, Philippines, 2010-2017 CONCLUSIONS: Considering the spatial heterogeneity and instability of hot spots in Quezon City across years, efforts towards the containment of dengue can be made more targeted, and efficient with the application of hot spot analysis in routine surveillance. This may be useful not only for the contr... 5/24/2023
Arun Kalava, Matthew Crowley, Gina Parsonis, Lucas Wiegand Efficacy of Pudendal Nerve Blocks and Ultrasound-Guided Superior Hypogastric Plexus Blocks for the Management of Refractory Interstitial Cystitis A Case Series Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by chronic pelvic, perineal, or bladder pain in addition to lower urinary tract symptoms. The etiology of this condition is not fully understood, which presents a challenge for effective therapeutic intervention. Current treatment... 5/19/2023
Sophie H Chung, Susanna W L de Geus, Grant Shewmaker, Kelsey S Romatoski, Frederick T Drake, Naomi Y Ko, Andrea L Merrill, Ariel E Hirsch, Jennifer F Tseng, Teviah E Sachs, Michael R Cassidy Axillary Lymph Node Dissection is Associated with Improved Survival Among Men with Invasive Breast Cancer and Sentinel Node Metastasis BACKGROUND: Male breast cancer (MBC) is rare, and management is extrapolated from trials that enroll only women. It is unclear whether contemporary axillary management based on data from landmark trials in women may also apply to men with breast cancer. This study aimed to compare survival in men wi... 5/19/2023
Joe James, Elizabeth Billington, Caroline J Warren, Dilhani De Sliva, Cecilia Di Genova, Maisie Airey, Stephanie M Meyer, Thomas Lewis, Jacob Peers-Dent, Saumya S Thomas, Abigail Lofts, Natalia Furman, Alejandro Nunez, Marek J Slomka, Ian H Brown, Ashley C Banyard Clade 2344b H5N1 high pathogenicity avian influenza virus HPAIV from the 202122 epizootic is highly duck adapted and poorly adapted to chickens The 2021/2022 epizootic of high pathogenicity avian influenza (HPAIV) remains one of the largest ever in the UK, being caused by a clade 2.3.4.4b H5N1 HPAIV. This epizootic affected more than 145 poultry premises, most likely through independent incursion from infected wild birds, supported by more ... 5/11/2023
Elizabeth Terman, Jori Sheade, Fangyuan Zhao, Frederick M Howard, Nora Jaskowiak, Jennifer Tseng, Nan Chen, Olwen Hahn, Gini Fleming, Dezheng Huo, Rita Nanda The impact of race and age on response to neoadjuvant therapy and long-term outcomes in Black and White women with early-stage breast cancer CONCLUSIONS: Black women with EBC had significantly worse outcomes compared to White women in our cohort study. There is an urgent need to understand the disparities in outcomes between Black and White breast cancer patients, particularly in young women where the disparity in outcome is the greatest... 4/29/2023
Kristian Brat, Michal Svoboda, Jaromir Zatloukal, Marek Plutinsky, Eva Volakova, Patrice Popelkova, Barbora Novotna, Tomas Dvorak, Vladimir Koblizek Prognostic Properties of the GOLD 2023 Classification System CONCLUSION: We concluded that the new GOLD classification system has poor prognostic properties and that specific prediction tools (eg, the BODE index) should be used for mortality risk assessment. 4/28/2023
Gordana Rasic, Brendin R Beaulieu-Jones, Sophie H Chung, Kelsey S Romatoski, Kelly Kenzik, Sing Chau Ng, Jennifer F Tseng, Teviah E Sachs The Impact of the COVID-19 Pandemic on Hepatocellular Carcinoma Time to Treatment Initiation A National Cancer Database Study CONCLUSIONS: For patients diagnosed during COVID, TTI for HCC, while statistically significant, had no clinically significant differences. However, vulnerable patients were more likely to have increased TTI. 4/26/2023
Eman H Ismail, Razvan I Ghinea, Luis J Herrera, Esam Tashkandi, Rade D Paravina Multicenter study on visual color difference thresholds A secondary analysis of light, medium, and dark tooth-colored specimens PURPOSE: This secondary analysis further analyzed variations in the 50:50% perceptibility and acceptability thresholds (PT and AT, respectively) pertaining to light, medium, and dark tooth-colored specimen sets. 4/19/2023
Pamela M Choi, Keith D Lillemoe, Jennifer F Tseng, Joshua M V Mammen, Meghann E Nelles, Lesly A Dossett, Luke M Funk Emerging From the Pandemic How Has Academic Surgery Changed Academic surgery has changed along with the rest of the world in response to the COVID pandemic. With increasing rates of vaccination against COVID over the past 2 y, we have slowly but steadily made progress toward controlling the spread of the virus. Surgeons, academic surgery departments, health ... 4/5/2023
Elizabeth Terman, Jori Sheade, Fangyuan Zhao, Frederick M Howard, Nora Jaskowiak, Jennifer Tseng, Nan Chen, Olwen Hahn, Gini Fleming, Dezheng Huo, Rita Nanda The Impact of Race and Age on Response to Neoadjuvant Therapy and Long-Term Outcomes in Black and White Women with Early-Stage Breast Cancer CONCLUSIONS: Black women with EBC had significantly worse outcomes compared to White women in our cohort study. There is an urgent need to understand the disparities in outcomes between Black and White breast cancer patients, particularly in young women where the disparity in outcome is the greatest... 3/30/2023
Hope Bercaw, Lauren A Reid, Jason A Mendoza, Edward A Frongillo, Katherine A Sauder, Beth A Reboussin, Elizabeth J Mayer-Davis, Dana Dabelea, Santica M Marcovina, Carla Mercado, Angela D Liese Food Insecurity and Adequacy of Dietary Intake in Youth and Young Adults With Youth-Onset Type 1 and Type 2 Diabetes CONCLUSIONS: Food insecurity is associated with lesser adherence to fiber and sodium guidelines in YYA with type 1 diabetes, which may lead to diabetes complications and other chronic diseases. 3/29/2023
Gordana Rasic, Susanna W L de Geus, Marianna V Papageorge, Alison P Woods, Sing Chau Ng, David McAneny, Jennifer F Tseng, Teviah E Sachs Disparities in the Receipt of Recommended Curative Treatment for Patients with Early-Stage Hepatocellular Carcinoma CONCLUSIONS: Racial and socioeconomic disparities persist in the decision to undergo recommended treatment. Underutilization of treatment acts as a barrier to addressing racial and socioeconomic disparities in early-stage HCC outcomes. 3/15/2023
Gordana Rasic, Susanna W L de Geus, Brendin Beaulieu-Jones, Gyulnara G Kasumova, Tara S Kent, Sing Chau Ng, David McAneny, Jennifer F Tseng, Teviah E Sachs A nationwide propensity score analysis comparing ablation and resection for hepatocellular carcinoma CONCLUSIONS: While resection offers a survival benefit over ablation in the treatment of early-stage HCC ≤50 mm, ablation may provide a feasible bridging strategy in patients awaiting transplantation. 3/11/2023
Sam L Forrest, Carmel L Mercado, Cyril M Engmann, Andrew W Stacey, Luxme Hariharan, Sadaf Khan, Michelle T Cabrera Does the Current Global Health Agenda Lack Vision Given increasing rates of visual impairment worldwide, we call on national health plans and global development agencies to urgently focus funding and resources toward vision and eye health, with an emphasis on data collection surrounding new and changing burden of eye disease. 2/28/2023
Jennifer Croland, Sarah Overton, Kelly Nimtz-Rusch, Sheryl Emmerling, Lori Wiegand Implementation of a Violence Risk Assessment and Interventions Aimed at the Prevention of Patient-Perpetrated Violent Events Across Care Settings Healthcare worker violence at the hands of patients is the leading cause of workplace injury with reports demonstrating yearly increases. Literature suggests organizational strategies to reduce workplace injury are necessary to create safe environments for patients to receive care and for healthcare... 2/23/2023
Shahnaz Shahid Ali, Tazeen Saeed Ali, Farzana Adnan, Nimira Asif, Zahid Memon, Samina Barkat, Sajid Soofi, Anum S Hussaini, Rozina Karmaliani Safe motherhood A hidden reality in Pakistan OBJECTIVE: To explore the perceptions and experiences of healthcare professionals, including female health visitors, female health workers, community midwives, and heads of departments of healthcare facilities, regarding the importance of the Safe Motherhood Initiative (SMI), its pillars, and its fo... 2/22/2023
Michael S Kent, Matthew G Hartwig, Eric Vallières, Abbas E Abbas, Robert J Cerfolio, Mark R Dylewski, Thomas Fabian, Luis J Herrera, Kimble G Jett, Richard S Lazzaro, Bryan Meyers, Rishindra M Reddy, Michael F Reed, David C Rice, Patrick Ross, Inderpal S Sarkaria, Lana Y Schumacher, Lawrence N Spier, William B Tisol, Dennis A Wigle, Michael Zervos Pulmonary Open, Robotic, and Thoracoscopic Lobectomy PORTaL Study Survival Analysis of 6646 Cases CONCLUSIONS: Our finding from this large multicenter study suggests that patients undergoing RL and OL have statistically similar OS, while the VATS group was associated with shorter OS. Further studies with longer follow-up are necessary to help evaluate these observations. 2/10/2023
Daniel Major-Smith, Tadeáš Dvořák, Ahmed Elhakeem, Deborah A Lawlor, Kate Tilling, Andrew D A C Smith Incorporating interactions into structured life course modelling approaches A simulation study and applied example of the role of access to green space and socioeconomic position on cardiometabolic health CONCLUSIONS: Incorporating interactions between multiple exposures is an important extension to SLCMA. The choice of method depends on the researchers' assessment of the risks of under- vs over-fitting. These results also provide guidance for improving power to detect interactions using these method... 2/7/2023
George S Liu, Jared A Shenson, Joyce E Farrell, Nikolas H Blevins Signal to noise ratio quantifies the contribution of spectral channels to classification of human head and neck tissues emex vivoem using deep learning and multispectral imaging CONCLUSIONS: The spectral channel SNR is a useful metric for both understanding CNN tissue classification and quantifying the contributions of different spectral channels in an MSI system. 2/2/2023
Amy I Laughlin, Tingting Li, Qingzhao Yu, Xiao-Cheng Wu, Yong Yi, Mei-Chin Hsieh, William Havron, Margo Shoup, Quyen D Chu Impact of Medicaid Expansion on Breast Cancer Diagnosis and Treatment in Southern States CONCLUSIONS: Unlike NMES, MES experienced increased Medicaid insured, increased treatment, and decreased distant-stage disease at diagnosis. Medicaid expansion in the South leads to earlier and more comprehensive treatment of breast cancer. 2/1/2023
Maria Tejada-Casado, Razvan Ghinea, María M Pérez, Javier Ruiz-López, Henning Lübbe, Luis Javier Herrera Development of Thickness-Dependent Predictive Methods for the Estimation of the CIELab Color Coordinates of Monolithic and Layered Dental Resin Composites Usually, dentin and enamel shades are layered in dental restorations with the purpose of mimicking the natural appearance of teeth. The main objective of this study was to develop and assess accuracy of a color-prediction method for both monolithic and layered dental resin-based composites with vary... 1/21/2023
Abdallah S Abdelsattar, Aghapy Yermans Yakoup, Yousef Khaled, Anan Safwat, Ayman El-Shibiny The synergistic effect of using bacteriophages and chitosan nanoparticles against pathogenic bacteria as a novel therapeutic approach Public health and environmental security are seriously at risk due to the growing contamination of pathogenic microorganisms. Therefore, effective antimicrobials are urgently needed. In our study, the antimicrobial effects of three types of nanoparticles were investigated with phage. The biosynthesi... 12/29/2022
Selma D Mezger, Annabell Klinke, Arjen Tilstra, Yusuf C El-Khaled, Bianca Thobor, Christian Wild The widely distributed soft coral Xenia umbellata exhibits high resistance against phosphate enrichment and temperature increase Both global and local factors affect coral reefs worldwide, sometimes simultaneously. An interplay of these factors can lead to phase shifts from hard coral dominance to algae or other invertebrates, particularly soft corals. However, most studies have targeted the effects of single factors, leaving... 12/22/2022
Isabella Bechara, Carolina Mercado, Juliana Muñoz-Ortiz, Alicia Montoya Characterization of patients with ocular pain evaluated with ultrasound CONCLUSION: Posterior inflammation is present in most patients with ocular pain in a quiet eye, and echography is an optimal tool to identify this. There is a tendency towards abnormal autoimmune test results and echographic findings. This should be considered in the initial work-up of these patient... 12/21/2022
Meredith Elana Giuliani, Nishin A Bhadkamkar, Eleni Giannopoulos, Sam Lubner, Jennifer Tseng, Michal Tibbits, Jamie H Von Roenn Advancing the Clinician Educator Career Pathway in Oncology CONCLUSION: Oncology PDs/APDs and fellows perceive the CE to be a viable career track. Greater advocacy efforts are needed to raise awareness about this career path. 12/19/2022
Roy Rillera Marzo, Yassmein Khaled, Mohamed ElSherif, Muhd Siv Azhar Merican Bin Abdullah, Hui Zhu Thew, Collins Chong, Shean Yih Soh, Ching Sin Siau, Shekhar Chauhan, Yulan Lin Burnout, resilience and the quality of life among Malaysian healthcare workers during the COVID-19 pandemic CONCLUSION: It is important to target physical as well as psychological wellbeing of the healthcare workers. Also, it is important to understand the contribution of long working hours in declining the quality of life of the healthcare workers. Thus, allocating fixed working hours for healthcare work... 12/19/2022
Jared A Shenson, Mark E Zafereo, Mark Lee, Kevin J Contrera, Lei Feng, Mongkol Boonsripitayanon, Neil Gross, Ryan Goepfert, Anastasios Maniakas, Jennifer Rui Wang, Libby Grubbs, Ara Vaporciyan, Wayne Hofstetter, Stephen Swisher, Reza Mehran, David Rice, Boris Sepesi, Mara Antonoff, Maria Cabanillas, Naifa Busaidy, Ramona Dadu, Natalie L Silver Clinical outcomes of combined cervical and transthoracic surgical approaches in patients with advanced thyroid cancer CONCLUSIONS: Combined transcervical and transthoracic surgery for advanced thyroid cancer can be performed without mortality and with acceptable morbidity. 12/16/2022
Luis J Herrera, Lana Y Schumacher, Matthew G Hartwig, Charles T Bakhos, Rishindra M Reddy, Eric Vallières, Michael S Kent Pulmonary Open, Robotic, and Thoracoscopic Lobectomy study Outcomes and risk factors of conversion during minimally invasive lobectomy CONCLUSIONS: Converted minimally invasive lobectomies were not associated with worse perioperative mortality compared with open lobectomy. Compared with VATS lobectomy, RL is associated with a lower probability of conversion in this propensity-score matched cohort study. 12/12/2022
Sam Z Thalji, Cecilia G Ethun, Susan Tsai, T Clark Gamblin, Callisia N Clarke, Meena Bedi, David King, John LoGiudice, George Poultsides, Valerie P Grignol, Jennifer Tseng, Konstantinos Votanopoulos, Ryan C Fields, Kenneth Cardona, Harveshp Mogal Outcomes of plastic surgical reconstruction in extremity and truncal soft tissue sarcoma Results from the US Sarcoma Collaborative CONCLUSION: Patients with ETSTS undergoing resection with PSR experienced acceptable rates of complications and a higher rate of negative margins, which were associated with improved LRRFS and OS. High tumor grade and neoadjuvant radiation were associated with requirement of PSR. 12/8/2022
Michael D Chuong, Mary Ann Clark, Lauren E Henke, Amar U Kishan, Lorraine Portelance, Parag J Parikh, Michael F Bassetti, Himanshu Nagar, Stephen A Rosenberg, Minesh P Mehta, Tamer Refaat, Justin M Rineer, Adam Smith, Steven Seung, Bassem I Zaki, Martin Fuss, Raymond H Mak Patterns of utilization and clinical adoption of 035 Tesla MR-guided radiation therapy in the United States - Understanding the transition to adaptive, ultra-hypofractionated treatments CONCLUSIONS: This is the first comprehensive study reporting patterns of utilization among early adopters of MRIdian in the US. Intrafraction MR image-guidance, advanced motion management, and increasing adoption of adaptive radiation therapy has led to a substantial transition to ultra-hypofraction... 12/5/2022
Robinson T Barrientos, Fernando Godín, Carlos Rocha-De-Lossada, Matias Soifer, José-María Sánchez-González, Esteban Moreno-Toral, Ana-Luisa González, Mike Zein, Pablo Larco, Carolina Mercado, Maria-Adelaida Piedrahita Ophthalmological Approach for the Diagnosis of Dry Eye Disease in Patients with Sjgrens Syndrome Dry eye has two basic subdivisions: aqueous deficient dry eye (ADDE), with SS a major cause; and evaporative dry eye (EDE), due to either intrinsic or extrinsic factors. SS is a chronic inflammatory disorder defined by dysfunction of the exocrine glands leading to dry eye and dry mouth. The objectiv... 11/26/2022
Siri H Strand, Belén Rivero-Gutiérrez, Kathleen E Houlahan, Jose A Seoane, Lorraine M King, Tyler Risom, Lunden A Simpson, Sujay Vennam, Aziz Khan, Luis Cisneros, Timothy Hardman, Bryan Harmon, Fergus Couch, Kristalyn Gallagher, Mark Kilgore, Shi Wei, Angela DeMichele, Tari King, Priscilla F McAuliffe, Julie Nangia, Joanna Lee, Jennifer Tseng, Anna Maria Storniolo, Alastair M Thompson, Gaorav P Gupta, Robyn Burns, Deborah J Veis, Katherine DeSchryver, Chunfang Zhu, Magdalena Matusiak, Jason Wang, Shirley X Zhu, Jen Tappenden, Daisy Yi Ding, Dadong Zhang, Jingqin Luo, Shu Jiang, Sushama Varma, Lauren Anderson, Cody Straub, Sucheta Srivastava, Christina Curtis, Rob Tibshirani, Robert Michael Angelo, Allison Hall, Kouros Owzar, Kornelia Polyak, Carlo Maley, Jeffrey R Marks, Graham A Colditz, E Shelley Hwang, Robert B West Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ Analysis of TBCRC 038 and RAHBT cohorts Ductal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We perform multiscale, integrated molecular profiling of DCIS with clinical outcomes by analyzing 774 DCIS samples from 542 patients with 7.3 years median follow-up... 11/18/2022
Lina Mahl, Johanna Ollig, Verena Schweihofer, Lara Wiegand, Phillipp Torkler, Silke Haerteis, Thiha Aung Importance and implications of exosomes in nephrology and urology Exosomes are extracellular vesicles that are formed by two invaginations of the plasma membrane and can be released by all eukaryotic cells. Because of their bioactive contents, including nucleic acids and proteins, exosomes can activate a variety of functions in their recipient cells. Due to the pl... 11/18/2022
Aiste Dobrovolskaite, Holly Moots, Mukund P Tantak, Kunal Shah, Jenna Thomas, Sharifa Dinara, Chelsea Massaro, Paul M Hershberger, Patrick R Maloney, Satyamaheshwar Peddibhotla, Eliot Sugarman, Sally Litherland, Juan Pablo Arnoletti, Rajiv Kumar Jha, David Levens, Otto Phanstiel Discovery of Anthranilic Acid Derivatives as Difluoromethylornithine Adjunct Agents That Inhibit Far Upstream Element Binding Protein 1 FUBP1 Function Polyamine biosynthesis is regulated by ornithine decarboxylase (ODC), which is transcriptionally activated by c-Myc. A large library was screened to find molecules that potentiate the ODC inhibitor, difluoromethylornithine (DFMO). Anthranilic acid derivatives were identified as DFMO adjunct agents. ... 11/16/2022
Yuan Liang, Charlotte K Hjulsager, Amanda H Seekings, Caroline J Warren, Fabian Z X Lean, Alejandro Núñez, Joe James, Saumya S Thomas, Ashley C Banyard, Marek J Slomka, Ian H Brown, Lars E Larsen Pathogenesis and infection dynamics of high pathogenicity avian influenza virus HPAIV H5N6 clade 2344b in pheasants and onward transmission to chickens High pathogenicity avian influenza viruses clade 2.3.4.4 H5 have spread among wild birds worldwide during recent years causing annual die-offs among wild birds and outbreaks in poultry in multiple European countries. The outbreaks significantly impact the poultry and game bird sectors. Infected game... 11/13/2022
Maria Tejada-Casado, Razvan Ghinea, Miguel Ángel Martínez-Domingo, María M Pérez, Juan C Cardona, Javier Ruiz-López, Luis Javier Herrera Validation of a Hyperspectral Imaging System for Color Measurement of In-Vivo Dental Structures A full comprehension of colorimetric relationships within and between teeth is key for aesthetic success of a dental restoration. In this sense, hyperspectral imaging can provide point-wise reliable measurements of the tooth surface, which can serve for this purpose. The aim of this study was to use... 11/11/2022
Deborah E Malden, Julianne Gee, Sungching Glenn, Zhuoxin Li, Cheryl Mercado, Oluwaseye A Ogun, Sunhea Kim, Bruno J Lewin, Bradley K Ackerson, Amelia Jazwa, Eric S Weintraub, Michael M McNeil, Sara Y Tartof Reactions following Pfizer-BioNTech COVID-19 mRNA vaccination and related healthcare encounters among 7,077 children aged 5-11 years within an integrated healthcare system CONCLUSION: While post-vaccination reactions to the Pfizer-BioNTech COVID-19 mRNA vaccine were common in children aged 5-11 years, our data showed that in most cases they were transient and did not require medical care. 11/9/2022
Hang Yin, Tabitha A Harrison, Sushma S Thomas, Cassie L Sather, Amanda L Koehne, Rachel C Malen, Adriana M Reedy, Michelle A Wurscher, Li Hsu, Amanda I Phipps, Syed H E Zaidi, Polly A Newcomb, Ulrike Peters, Jeroen R Huyghe T cell-inflamed gene expression profile is associated with favorable disease-specific survival in non-hypermutated microsatellite-stable colorectal cancer patients CONCLUSIONS: Our results show that the T cell-inflamed GEP is a prognostic biomarker in non-hypermutated microsatellite-stable CRC. This also suggests that patient stratification for immunotherapy within this CRC subgroup should be explored further. Moreover, reported immune-inhibitory gene expressi... 11/7/2022
Shalom Sara Thomas, Youn-Soo Cha, Kyung-Ah Kim Protective Effect of Perilla Oil Against Dextran Sodium Sulfate-Induced Colitis in Mice Challenged with a High-Fat Diet This study investigated the effect of perilla oil (PO) on an ulcerative colitis mouse model. Five-week-old male C57BL/6J mice were divided into HD (high-fat diet control), HDD (high-fat diet along with dextran sodium sulfate [DSS] administration), HDD + FO, HDD + PO, and HDD + OO where HDD + FO, HDD... 11/2/2022
Nandini Venkateswaran, Carolina Mercado, Sarah C Wall, Anat Galor, Jianhua Wang, Carol L Karp High resolution anterior segment optical coherence tomography of ocular surface lesions A review and handbook INTRODUCTION: High resolution anterior segment optical coherence tomography (HR-OCT) has revolutionized the way by which clinicians can diagnose and differentiate ocular surface lesions. Careful interpretation of HR-OCT images can provide morphological information about the lesion of interest and he... 10/31/2022
Ernesto Otero, Carolina Mercado Limbal advancement technique in managing acute or impending peripheral corneal perforations CONCLUSION: In conclusion, this technique is a cost-effective and straightforward alternative for the repair of impending acute peripheral perforations. 10/25/2022
Olivet Chiamaka Edward, Shalom Sara Thomas, Kyung-Ok Cha, Hyun-Ah Jung, Anna Han, Youn-Soo Cha Green perilla leaf extract ameliorates long-term oxidative stress induced by a high-fat diet in aging mice CONCLUSIONS: This research opens opportunities for further investigations of PE as a functional food and possible anti-aging agent due to its attenuative effects against oxidative stress, resulting from HFD and aging in the future. 10/14/2022
Jana tundlová, Monika Hospodářská, Karolína Lukšíková, Anna Voleníková, Tomáš Pavlica, Marie Altmanová, Annekatrin Richter, Martin Reichard, Martina Dalíková, árka Pelikánová, Anatolie Marta, Sergey A Simanovsky, Matyáš Hiřman, Marek Jankásek, Tomáš Dvořák, Joerg Bohlen, Petr Ráb, Christoph Englert, Petr Nguyen, Alexandr Sember Sex chromosome differentiation via changes in the Y chromosome repeat landscape in African annual killifishes Nothobranchius furzeri and N kadleci Homomorphic sex chromosomes and their turnover are common in teleosts. We investigated the evolution of nascent sex chromosomes in several populations of two sister species of African annual killifishes, Nothobranchius furzeri and N. kadleci, focusing on their under-studied repetitive landscape. We ... 10/8/2022
Amanda L Nash, Samantha M Thomas, Suniti N Nimbkar, Tina J Hieken, Kandice K Ludwig, Lisa K Jacobs, Megan E Miller, Kristalyn K Gallagher, Jasmine Wong, Heather B Neuman, Jennifer Tseng, Taryn E Hassinger, Tari A King, E Shelley Hwang, James W Jakub, Laura H Rosenberger Racial-ethnic variations in phyllodes tumors among a multicenter United States cohort CONCLUSIONS: Differences in age, tumor size, and subtype were small. Therefore, the workup of young women with breast masses and the treatment of women with PT should not differ according to race-ethnicity. These conclusions are supported by our finding that there were no differences in recurrence-f... 10/7/2022
David A D'Alessandro, Stanley B Wolfe, Asishana A Osho, Kamila Drezek, Monica N Prario, S Alireza Rabi, Eriberto Michel, Lana Tsao, Erin Coglianese, Meaghan Doucette, Daniel A Zlotoff, Christopher Newton-Cheh, Sunu S Thomas, Van-Khue Ton, Nilay Sutaria, Mark W Schoenike, Anastasia M Christ, Dane C Paneitz, Joren C Madsen, Richard Pierson, Gregory D Lewis Hemodynamic and Clinical Performance of Hearts Donated After Circulatory Death CONCLUSIONS: DCD heart utilization is associated with transient post-transplant right heart dysfunction and short-term clinical outcomes otherwise similar to transplantation using DBD hearts. 9/29/2022
Brian S Schwartz, Marynia Kolak, Jonathan S Pollak, Melissa N Poulsen, Karen Bandeen-Roche, Katherine A Moon, Joseph DeWalle, Karen R Siegel, Carla I Mercado, Giuseppina Imperatore, Annemarie G Hirsch Associations of four indexes of social determinants of health and two community typologies with new onset type 2 diabetes across a diverse geography in Pennsylvania Evaluation of geographic disparities in type 2 diabetes (T2D) onset requires multidimensional approaches at a relevant spatial scale to characterize community types and features that could influence this health outcome. Using Geisinger electronic health records (2008-2016), we conducted a nested cas... 9/16/2022
Omar A Zeidan, Ethan Pepmiller, Twyla Willoughby, Zhiqiu Li, James Burkavage, Brian Harper, Michael Fraser, Katie Moffatt, Sanford L Meeks, Naren Ramakrishna Operational Performance of a Compact Proton Therapy System A 5-Year Experience CONCLUSION: Our data show that this compact system is versatile, robust, and capable of delivering complex treatments like a large full-gantry system. Utilization data show that a fraction of all subcomponents range of angular motion has been used. Compilation of beam-specific metrics, such as range... 9/5/2022
Marianna V Papageorge, Susanna W L de Geus, Alison P Woods, Sing Chau Ng, Samuel Lee, David McAneny, Jennifer F Tseng, Kelly M Kenzik, Teviah E Sachs Surveillance Patterns for Hepatocellular Carcinoma among Screening-Eligible Patients in the Medicare Population CONCLUSIONS: A large proportion of screening-eligible patients do not undergo routine surveillance, which is associated with late-stage diagnosis and higher risk of mortality. These findings demonstrate the impact of timely and consistent healthcare access and can guide interventions for promoting s... 9/4/2022
Adnan S Hussaini, Daniel D Swanson, Peter L Nguy, Kristen S Pan, Luis F de Castro, Alison M Boyce, Michael T Collins, Timothy R DeKlotz Malignant Sarcomatous Degeneration of Craniofacial Fibrous Dysplasia BACKGROUND: Fibrous dysplasia (FD) is an uncommon bone disease characterized by the replacement of normal bone architecture with abnormal fibro-osseous connective tissue. Here, we discuss 2 cases of craniofacial FD, with malignant sarcomatous degeneration - a rare and morbid complication of the dise... 9/2/2022
Tereza Hendrychova, Michal Svoboda, Josef Maly, Jiri Vlcek, Eva Zimcikova, Tomas Dvorak, Jaromir Zatloukal, Eva Volakova, Marek Plutinsky, Kristian Brat, Patrice Popelkova, Michal Kopecky, Barbora Novotna, Vladimir Koblizek Self-Reported Overall Adherence and Correct Inhalation Technique Discordance in Chronic Obstructive Pulmonary Disease Population Background: Adherence to inhaled medication constitutes a major problem in patients with chronic obstructive pulmonary disease (COPD) globally. However, large studies evaluating adherence in its entirety and capturing a large variety of potentially associated factors are still lacking. Objective: To... 8/29/2022
Swetha Duraiswamy, Sabrina E Sanchez, David R Flum, Michael K Paasche-Orlow, Kelly M Kenzik, Jennifer F Tseng, Frederick Thurston Drake Caveat emptor The accuracy of claims data in appendicitis research CONCLUSION: International Classification of Disease, ninth/tenth revision codes do not accurately identify surgeon-described complicated appendicitis. Nearly one-third of the cases of complicated appendicitis were coded as uncomplicated. Such misclassification negatively impacts reimbursement for co... 8/19/2022
Aaron M Wolfson, Eugene C DePasquale, Michael W Fong, Kruti Pandya, Leon Zhou, Eric S Kawaguchi, Sunu S Thomas, Ajay S Vaidya UNOS policy change benefits high-priority patients without harming those at low priority The heart transplantation policy change (PC) has improved outcomes in high-acuity (Old 1A, New 1-3) patients, but the effect on low-priority (Old 1B/2, New 4-6) patients is unknown. We sought to determine if low-priority patient outcomes were compromised by benefits to high-priority patients by eval... 8/17/2022
Charles A Gusho, David King, Cecilia G Ethun, Kenneth Cardona, J Harrison Howard, Thuy B Tran, George Poultsides, Jennifer Tseng, Kevin K Roggin, Ryan C Fields, Darren R Cullinan, Konstantinos Chouliaras, Konstantinos Votanopoulos, Valerie P Grignol, Meena Bedi Extraskeletal myxoid chondrosarcoma Clinicopathological features and outcomes from the United States sarcoma collaborative database CONCLUSIONS: Long-term survival with EMC is probable, however there exists a high incidence of locoregional recurrence. While chemotherapy and radiation were associated with a worse RFS, these findings were likely confounded by recurrent disease as significance was lost in the primary EMC-only subse... 8/13/2022
Kevin J Contrera, Andrew T Huang, Jared A Shenson, Chad Tang, Dianna Roberts, Jeffrey N Myers, Randal S Weber, Stephen Y Lai, Michelle Williams, Maria El-Hallal, Denny Jacob, Mark Zafereo Primary and recurrent regional metastases for lateralized oral cavity squamous cell carcinoma CONCLUSIONS: For lateralized OCSCC, elective neck dissection of level IIB or the contralateral neck may rarely be needed, but additional surgical or radiation treatment of levels IV and V may be considered based on patient risk factors, including T category 3-4 or LVI. For upper alveolar/hard palate... 8/6/2022
Carolina Mercado, Juliana Muñoz-Ortiz, Fernando Godin, Anat Galor Confocal Microscopy Abnormalities Preceding Antibody Positivity and Manifestations of Sjogrens Syndrome An asymptomatic 26-year-old woman underwent confocal microscopy as part of a control population for a research study. Images revealed reduced sub-basal corneal nerve density and multiple activated dendritic cells. Three years later, she presented with a self-limited cutaneous vasculitis in her lower... 8/1/2022
Leonardo Pozo Garcia, Sandhya S Thomas, Harsith Rajesh, Sankar D Navaneethan Progress in the management of patients with diabetes and chronic kidney disease PURPOSE OF REVIEW: Diabetic kidney disease is the most common cause of chronic kidney disease (CKD) and end-stage kidney disease in the world. Risk factor modification, glucose control, and renin-angiotensin-aldosterone system blockade have remained the standard of care for 2 decades. New therapeuti... 7/27/2022
Shalom Sara Thomas, Youn-Soo Cha, Kyung-Ah Kim Protective Effect of Diet-Supplemented and Endogenously Produced Omega-3 Fatty Acids against HFD-Induced Colon Inflammation in Mice Perilla (Perilla frutescens) oil reduces high-fat-diet-induced colon inflammation by suppressing the NF-κB pathway. In the current study, we compared the effect of endogenously produced and externally supplemented omega-3 fatty acids on high-fat-diet-induced colon inflammation. The fat-1 transgenic ... 7/27/2022
Paige Teller, Toan T Nguyen, Jennifer Tseng, Lisa Allen, Cindy B Matsen, Emily Bellavance, David Kaufman, Tina Hieken, Steven Nagel, Caitlin Patten, Laura Pomerenke, Sarah E Tevis, Terry Sarantou Innovation in Breast Surgery Practical and Ethical Considerations The adoption of innovation is essential to the evolution of patient care. Breast surgical oncology advances through incorporating new techniques, devices, and procedures. Historical changes in practice standards from radical to modified radical mastectomy or axillary node dissection to sentinel node... 7/19/2022
Hadia Arzoun, Mirra Srinivasan, Mona Adam, Siji S Thomas, Amber Kuta, Stephanie Sandoval Evaluation of and Current Trends in the Management of Gastrointestinal Stromal Tumors A Systematic Review Gastrointestinal stromal tumors (GISTs) are soft-tissue sarcomas that can occur anywhere in the digestive tract, with the stomach and small intestine being the most common locations. Because no imaging modalities diagnose GIST unequivocally, histological and immunohistochemical confirmation is usual... 7/18/2022
Carmel L Mercado, Colin P Froines, Eric D Gaier, Qinyun Wang, Maanasa Indaram, Michael J Wan, Ankoor S Shah, Euna B Koo Prevalence and Characteristics of Cytomegalovirus Ocular Disease in Children A Multi-Center Study CONCLUSION: CMV ocular disease was a rare occurrence in this cohort without an identifiable pattern across sub-groups. Excluding the three congenital CMV cases, nine out of ten patients with CMV ocular disease were status post-stem cell transplantation. We provide integrated screening guidelines bas... 7/15/2022
Michael Padgett, Shivam M Kharod, Catherine E Mercado, Christopher G Morris, Michael S Rutenberg, Romaine C Nichols Patterns-of-care disparities among uninsured versus insured patients with anorectal carcinoma referred for radiotherapy at an Urban Safety-Net Hospital CONCLUSIONS: Differences in health insurance status demonstrated various disparities in patterns-of-care, including significant delay in diagnosis, more advanced-stage disease at presentation, and treatment initiation delays among UPs. Nevertheless, overall survival at 5 years was not statistically ... 7/15/2022
Marianna V Papageorge, Alison P Woods, Susanna W L de Geus, Sing Chau Ng, David McAneny, Jennifer F Tseng, Kelly M Kenzik, Teviah E Sachs The Persistence of Poverty and its Impact on Cancer Diagnosis, Treatment and Survival CONCLUSIONS: The duration of poverty has a direct impact on cancer-specific outcomes, with the greatest effect seen in persistent poverty and resolution of disparities when a county is no longer in poverty. Policy focused on directing resources to communities in persistent poverty may represent a po... 7/7/2022
María M Pérez, Francisco Carrillo-Perez, Maria Tejada-Casado, Javier Ruiz-López, Cristina Benavides-Reyes, Luis Javier Herrera CIEDE2000 lightness, chroma and hue human gingiva thresholds CONCLUSIONS: Statistically differences in perceptual limit were found among hue, lightness and chroma for human gingiva. Thus, the observers seem to show lower sensitivity for changes in hue (ΔH^(')) than in chroma (ΔC^(')) and in lightness (ΔL^(')) in the gingiva color space. 7/6/2022
Shawn Sam Thomas, Arundhati Marathe, Anish Jacob Cherian, N Siddhartha, Gowri Mahasampath, Manipadam Marie Therese, Chandramohan Jagan, Hesarghatta Shyamasunder Asha, Nihal Thomas, Ashish Singh, B Selvamani, Mazhuvanchary Jacob Paul, Deepak Thomas Abraham Adrenocortical Carcinoma a Therapeutic Challenge - 44 Cases from a Single Tertiary Care Center in India This study was conducted among patients with adrenocortical carcinoma (ACC) to analyze their clinico-pathological profile, management outcomes, and risk factors for local recurrence, systemic metastasis, and survival. The data of patients with ACC who were managed at a single institution between Jan... 7/5/2022
Michel Engeln, Megan E Fox, Ramesh Chandra, Eric Y Choi, Hyungwoo Nam, Houman Qadir, Shavin S Thomas, Victoria M Rhodes, Makeda D Turner, Rae J Herman, Cali A Calarco, Mary Kay Lobo Transcriptome profiling of the ventral pallidum reveals a role for pallido-thalamic neurons in cocaine reward Psychostimulant exposure alters the activity of ventral pallidum (VP) projection neurons. However, the molecular underpinnings of these circuit dysfunctions are unclear. We used RNA-sequencing to reveal alterations in the transcriptional landscape of the VP that are induced by cocaine self-administr... 6/28/2022
Hongchun Lin, Xinxin Ma, Yuxiang Sun, Hui Peng, Yanlin Wang, Sandhya Sara Thomas, Zhaoyong Hu Decoding the transcriptome of denervated muscle at single-nucleus resolution CONCLUSIONS: Our results define the myonuclear transition, metabolic remodelling, and gene regulation networks reprogramming associated with denervation-induced muscle atrophy and illustrate the molecular basis of the heterogeneity and plasticity of muscle cells in response to catabolism. These resu... 6/21/2022
Sandhya S Thomas, Jiao Wu, Giovanni Davogustto, Michael W Holliday, Kristin Eckel-Mahan, Daniela Verzola, Giacomo Garibotto, Zhaoyong Hu, William E Mitch, Heinrich Taegtmeyer SIRP Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease CONCLUSIONS: Myokine SIRPα expression impairs insulin/IGF1R functions in cardiac muscle, affecting cardiometabolic signaling pathways. Circulating SIRPα constitutes an important readout of insulin resistance in CKD-induced cardiomyopathy. 6/20/2022
Susanna Wl de Geus, Marianna V Papageorge, Alison P Woods, Spencer Wilson, Sing Chau Ng, Andrea Merrill, Michael Cassidy, David McAneny, Jennifer F Tseng, Teviah E Sachs A Rising Tide Lifts All Boats Impact of Combined Volume of Complex Cancer Operations on Surgical Outcomes in a Low-Volume Setting CONCLUSION: Patients who underwent complex operations at MVH had similar postoperative outcomes to those at HVH. MVH provide a model for the centralization of complex cancer surgery for patients who do not receive their care at HVH. 6/15/2022
Yusuf C El-Khaled, Nauras Daraghmeh, Arjen Tilstra, Florian Roth, Markus Huettel, Felix I Rossbach, Edoardo Casoli, Anna Koester, Milan Beck, Raïssa Meyer, Julia Plewka, Neele Schmidt, Lisa Winkelgrund, Benedikt Merk, Christian Wild Fleshy red algae mats act as temporary reservoirs for sessile invertebrate biodiversity Many coastal ecosystems, such as coral reefs and seagrass meadows, currently experience overgrowth by fleshy algae due to the interplay of local and global stressors. This is usually accompanied by strong decreases in habitat complexity and biodiversity. Recently, persistent, mat-forming fleshy red ... 6/13/2022
Fernando Godin, Carolina Mercado, Pablo Larco, Maria A Pacheco L, Davide Borroni, Alberto Chacon Aponte Epithelial downgrowth leading to graft rejection after penetrating keratoplasty CONCLUSIONS: Epithelial downgrowth is an uncommon complication of penetrating keratoplasty. It affects the patients' visual acuity and graft survival. Clinical observation is preferred in severe cases due to the high risk of intraocular damage; intracameral 5FU promises to be a good option in these ... 6/2/2022
Sharon H Giordano, Maria Alice B Franzoi, Sarah Temin, Carey K Anders, Sarat Chandarlapaty, Jennie R Crews, Jeffrey J Kirshner, Ian E Krop, Nancy U Lin, Aki Morikawa, Debra A Patt, Jane Perlmutter, Naren Ramakrishna, Nancy E Davidson Systemic Therapy for Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer ASCO Guideline Update PURPOSE: To update evidence-based guideline recommendations to practicing oncologists and others on systemic therapy for patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer. 5/31/2022
Naren Ramakrishna, Carey K Anders, Nancy U Lin, Aki Morikawa, Sarah Temin, Sarat Chandarlapaty, Jennie R Crews, Nancy E Davidson, Maria Alice B Franzoi, Jeffrey J Kirshner, Ian E Krop, Debra A Patt, Jane Perlmutter, Sharon H Giordano Management of Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases ASCO Guideline Update PURPOSE: To provide updated evidence- and consensus-based guideline recommendations to practicing oncologists and others on the management of brain metastases for patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer up to 2021. 5/31/2022
Patapios A Patapiou, Marek J Slomka, Amanda H Seekings, Joe James, Saumya S Thomas, Scott M Reid, Rowena D E Hansen, Nicola S Lewis, Ashley C Banyard JMM Profile Avian influenza a veterinary pathogen with zoonotic potential Avian influenza viruses (AIVs) are classified as either low pathogenicity (LP; generally causing sub-clinical to mild infections) or high pathogenicity (HP; capable of causing significant mortality events in birds). To date, HPAIVs appear o be restricted to the haemagglutinin (HA) glycoprotein H5 an... 5/31/2022
Peter J Hoskin, Kirsten Hopkins, Vivek Misra, Tanya Holt, Rhona McMenemin, Fiona McKinna, Krishnaswamy Madhavan, Andrew Bates, Noelle O'Rourke, Jason F Lester, Tim Sevitt, Daniel Roos, Gillian Brown, Sharon Shibu Thomas, Sharon Forsyth, Krystyna Reczko, Allan Hackshaw, Catherine O'Hara, Andre Lopes Prognostic factors for survival and ambulatory status at 8 weeks with metastatic spinal cord compression in the SCORAD randomised trial CONCLUSIONS: Primary breast or prostate cancer, and good ambulatory status at presentation, are favourable prognostic factors for both survival and ambulation after treatment. 5/26/2022
Chengyi Zheng, Jonathan Duffy, In-Lu Amy Liu, Lina S Sy, Ronald A Navarro, Sunhea S Kim, Denison S Ryan, Wansu Chen, Lei Qian, Cheryl Mercado, Steven J Jacobsen Identifying Cases of Shoulder Injury Related to Vaccine Administration SIRVA in the United States Development and Validation of a Natural Language Processing Method CONCLUSIONS: The algorithm performed with high sensitivity and reasonable specificity in identifying positive SIRVA cases. The NLP algorithm can potentially be used in future population-based studies to identify this rare adverse event, avoiding labor-intensive chart review validation. 5/24/2022
Tracy S Wang, Eugene S Kim, Quan-Yang Duh, Ankush Gosain, Lillian S Kao, Anai N Kothari, Susan Tsai, Jennifer F Tseng, Allan Tsung, Kasper S Wang, Steven D Wexner Proceedings From the Advances in Surgery Channel Diversity, Equity, and Inclusion Series Lessons Learned From Asian Academic Surgeons In this series of talks and the accompanying panel session, leaders from the Society of Asian Academic Surgeons discuss issues faced by Asian Americans and the importance of the role of mentors and allyship in professional development in the advancement of Asian Americans in leadership roles. Barrie... 5/19/2022
Levannie A Mabuti, Ian Kenneth S Manding, Candy C Mercado Photovoltaic and photocatalytic properties of bismuth oxyiodide-graphene nanocomposites In this study, we evaluate the photovoltaic and photocatalytic properties of chemical vapor deposited bismuth oxyiodide (BiOI) and bismuth oxyiodide-graphene (BiOI-GR) nanocomposite thin films. The BiOI thin film has an average thickness of 574 nm and a bandgap of around 2 eV. The BiOI and BiOI-GR t... 5/13/2022
Mirza Zain Baig, Syed S Razi, Kojo Agyabeng-Dadzie, Stephanie Stroever, Zaid Muslim, Joanna Weber, Luis J Herrera, Faiz Y Bhora Robotic-assisted thoracoscopic surgery demonstrates a lower rate of conversion to thoracotomy than video-assisted thoracoscopic surgery for complex lobectomies CONCLUSIONS: Our analysis of the National Cancer Database suggests that robotic lobectomy for complex lung resections achieves similar perioperative outcomes and R0 resections as VATS lobectomy with the exception of a lower rate of conversion to thoracotomy. 5/11/2022
Angela Gomez, Carolina Mercado, Nandini Venkateswaran, Borja de la Sen-Corcuera, Darlene Miller, Sander Dubovy, Enrique Salero, Alfonso L Sabater Brief incubation of corneal grafts in activated platelet rich plasma enhances corneal endothelial cell survival and regeneration Corneal transplantation is the most frequent organ transplantation worldwide. Unfortunately, corneal graft failure is common and endothelial decompensation is considered the major cause. Corneal endothelial cells (CECs) lack the capacity to reproduce, and perioperative and postoperative endothelial ... 5/3/2022
Zaid Muslim, Stephanie Stroever, Kostantinos Poulikidis, Joanna F Weber, Cliff P Connery, Luis J Herrera, Faiz Y Bhora Conversion to Thoracotomy in Non-Small Cell Lung Cancer Risk Factors and Perioperative Outcomes Objective: We aimed to identify predictors of conversion to thoracotomy and test the hypothesis that conversion is associated with inferior perioperative outcomes in non-small cell lung cancer (NSCLC). Methods: We queried the National Cancer Database for patients with stage I to III NSCLC undergoing... 5/2/2022
Francisco Carrillo-Perez, Juan Carlos Morales, Daniel Castillo-Secilla, Olivier Gevaert, Ignacio Rojas, Luis Javier Herrera Machine-Learning-Based Late Fusion on Multi-Omics and Multi-Scale Data for Non-Small-Cell Lung Cancer Diagnosis Differentiation between the various non-small-cell lung cancer subtypes is crucial for providing an effective treatment to the patient. For this purpose, machine learning techniques have been used in recent years over the available biological data from patients. However, in most cases this problem h... 4/23/2022
Sergio Ortiz, Fernando Rojas, Olga Valenzuela, Luis Javier Herrera, Ignacio Rojas Determination of the Severity and Percentage of COVID-19 Infection through a Hierarchical Deep Learning System The coronavirus disease 2019 (COVID-19) has caused millions of deaths and one of the greatest health crises of all time. In this disease, one of the most important aspects is the early detection of the infection to avoid the spread. In addition to this, it is essential to know how the disease progre... 4/23/2022
Christopher A French, Michael L Cheng, Glenn J Hanna, Steven G DuBois, Nicole G Chau, Christine L Hann, Simone Storck, Ravi Salgia, Matteo Trucco, Jennifer Tseng, Anastasios Stathis, Richard Piekarz, Ulrich M Lauer, Christophe Massard, Kelly Bennett, Shodeinde Coker, Ulrike Tontsch-Grunt, Martin L Sos, Sida Liao, Catherine J Wu, Kornelia Polyak, Sarina A Piha-Paul, Geoffrey I Shapiro Report of the First International Symposium on NUT Carcinoma NUT carcinoma is a rare, aggressive cancer defined by rearrangements of the NUTM1 gene. No routinely effective treatments of NUT carcinoma exist, despite harboring a targetable oncoprotein, most commonly BRD4-NUT. The vast majority of cases are fatal. Poor awareness of the disease is a major obstacl... 4/13/2022
E Charles Fortune, Catherine E Mercado, Peter A Drew, Christopher G Morris, Robert J Amdur Adjuvant I-131 therapy for T0-3 N1b M0 differentiated thyroid cancer with many 5 positive nodes CONCLUSION: Recurrence was infrequent in our study population with ≥ 5 positive nodes following moderate-dose adjuvant I-131 treatment. These results are valuable in directing initial adjuvant therapy and follow-up intensity. Our results do not inform the question of the use of postoperative thyrogl... 4/11/2022
Meenu Bajpai, Ashish Maheshwari, Vikas Dogra, Suresh Kumar, Ekta Gupta, Pratibha Kale, Vandana Saluja, Sherin S Thomas, Nirupama Trehanpati, Chhagan Bihari, Reshu Agarwal, Praveen Bharti, Prabha Shankar, Javid Hussain, Karan Chhabra, Amita Gupta, Ashad Narayanan, Sarika Agarwal, Shruti Jain, Ankit Bhardwaj, Guresh Kumar, Birendra Kumar Yadav, Shiv Kumar Sarin Efficacy of convalescent plasma therapy in the patient with COVID-19 a randomised control trial COPLA-II trial CONCLUSION AND RELEVANCE: Convalescent plasma with adequate antibody titres should be transfused in COVID-19 patients along with SMT in the initial 3 days of hospitalisation for better clinical outcomes. 4/7/2022
Karthik Ramesh, Eric A Mellon, Saumya S Gurbani, Brent D Weinberg, Eduard Schreibmann, Sulaiman A Sheriff, Mohammed Goryawala, Macarena de le Fuente, Bree R Eaton, Jim Zhong, Alfredo D Voloschin, Soma Sengupta, Erin M Dunbar, Matthias Holdhoff, Peter B Barker, Andrew A Maudsley, Lawrence R Kleinberg, Hyunsuk Shim, Hui-Kuo G Shu A multi-institutional pilot clinical trial of spectroscopic MRI-guided radiation dose escalation for newly diagnosed glioblastoma CONCLUSION: Dose-escalated RT to 75 Gy guided by sMRI appears feasible and safe for patients with newly diagnosed GBMs. OS outcome is promising and warrants additional testing. Based on these results, a randomized phase II trial is in development. 4/6/2022
Mirra Srinivasan, Santhosh Raja Thangaraj, Hadia Arzoun, Siji S Thomas, Lubna Mohammed The Impact of Bariatric Surgery on Cardiovascular Risk Factors and Outcomes A Systematic Review Obesity and its complications are increasing in today's era, with cardiovascular health being one of the most significant obesity-related comorbidities. Hypertension in obesity is considered one of the major causes of death and disability due to their negative repercussions on cardiovascular health.... 4/4/2022
Chloe M Chhor, Nancy R Fefferman, Patricia M Clayton, Cecilia L Mercado Impact of Longitudinal Focused Academic Time on Resident Scholarly Activity CONCLUSION: Longitudinal focused academic time of half a day per week increased productivity of scholarly activity among our radiology residents. 4/1/2022
Katia Bruxvoort, Jeff Slezak, Lei Qian, Lina S Sy, Bradley Ackerson, Kristi Reynolds, Runxin Huang, Zendi Solano, William Towner, Cheryl Mercado, Steven J Jacobsen Association Between 2-Dose vs 3-Dose Hepatitis B Vaccine and Acute Myocardial Infarction CONCLUSIONS AND RELEVANCE: In this cohort study, receipt of HepB-CpG vaccine compared with HepB-alum vaccine did not meet the statistical criterion for increased risk of acute myocardial infarction. 3/25/2022
Juan Pablo Arnoletti, Joseph Reza, Armando Rosales, Alberto Monreal, Na'im Fanaian, Suzanne Whisner, Milan Srivastava, Julia Rivera-Otero, Gongxin Yu, Otto Phanstiel Iv, Deborah A Altomare, Quang Tran, Sally A Litherland Pancreatic Ductal Adenocarcinoma PDAC circulating tumor cells influence myeloid cell differentiation to support their survival and immunoresistance in portal vein circulation The portal venous circulation provides a conduit for pancreatic ductal adenocarcinoma (PDAC) tumor cells to the liver parenchyma sinusoids, a frequent site of metastasis. Turbulent flow in the portal circulation promotes retention of PDAC shed circulating tumor cells (CTC) and myeloid-derived immuno... 3/22/2022
Karen Xu, Karthik Ramesh, Vicki Huang, Saumya S Gurbani, James Scott Cordova, Eduard Schreibmann, Brent D Weinberg, Soma Sengupta, Alfredo D Voloschin, Matthias Holdhoff, Peter B Barker, Lawrence R Kleinberg, Jeffrey J Olson, Hui-Kuo G Shu, Hyunsuk Shim Final Report on Clinical Outcomes and Tumor Recurrence Patterns of a Pilot Study Assessing Efficacy of Belinostat PXD-101 with Chemoradiation for Newly Diagnosed Glioblastoma Glioblastoma (GBM) is highly aggressive and has a poor prognosis. Belinostat is a histone deacetylase inhibitor with blood-brain barrier permeability, anti-GBM activity, and the potential to enhance chemoradiation. The purpose of this clinical trial was to assess the efficacy of combining belinostat... 3/22/2022
Chengyi Zheng, Jonathan Duffy, In-Lu Amy Liu, Lina S Sy, Wansu Chen, Lei Qian, Ronald A Navarro, Denison S Ryan, Sunhea S Kim, Cheryl Mercado, Steven J Jacobsen Risk for Shoulder Conditions After Vaccination A Population-Based Study Using Real-World Data CONCLUSION: These population-based data suggest a small absolute risk for shoulder conditions after vaccination. Given the high burden of shoulder conditions, clinicians should pay attention to any factors that may further increase risks. 3/21/2022
Shimaa Mohamed Elsaeed, Elsayed Gamal Zaki, Ahmed Abdelhafes, Ayman S Al-Hussaini Response Surface Method Based Modeling and Optimization of CMC-g Terpolymer Interpenetrating NetworkBentonite Superabsorbent Composite for Enhancing Water Retention Water shortages have become a serious issue, so the importance of developing innovative cellulose-based superabsorbent polymer (SAP) was experimentally assessed as an environmentally friendly alternative to acrylate-based SAPs for the optimization of water consumption. The development of a biodegrad... 3/21/2022
Carolina Mercado, Mario Perez-Rueda An Atypical Case of Miller Fisher Syndrome with Multiple Autoimmunity Miller Fisher syndrome (MFS) is a rare variant of Guillain-Barré syndrome that is characterised by ataxia, ophthalmoplegia, and areflexia. Its relation with other autoimmune diseases is scarcely found in the literature, and in those few cases, treatment has been especially difficult. We report a cas... 3/11/2022
Frank M Kagoro, Karen I Barnes, Kevin Marsh, Nattwut Ekapirat, Chris Erwin G Mercado, Ipsita Sinha, Georgina Humphreys, Mehul Dhorda, Philippe J Guerin, Richard J Maude Mapping genetic markers of artemisinin resistance in emPlasmodium falciparumem malaria in Asia a systematic review and spatiotemporal analysis BACKGROUND: The increase in artemisinin resistance threatens malaria elimination in Asia by the target date of 2030 and could derail control efforts in other endemic regions. This study aimed to develop up-to-date spatial distribution visualisations of the kelch13 (K13) gene markers of artemisinin r... 3/10/2022
Swetha Duraiswamy, Amanda Ignacio, Janice Weinberg, Sabrina E Sanchez, David R Flum, Michael K Paasche-Orlow, Kelly M Kenzik, Jennifer F Tseng, Frederick Thurston Drake Comparative Accuracy of ICD-9 vs ICD-10 Codes for Acute Appendicitis CONCLUSIONS: Compared with ICD-9 codes, ICD-10 codes were less accurate in characterizing severity of appendicitis. The ICD-10 coding schema does not provide an accurate representation of disease severity. Until this system is improved, significant caution is needed for people who rely on these data... 2/25/2022
Tomáš Dvořák, Vendula lechtová, Jörg Bohlen Using Species Groups to Approach the Large and Taxonomically Unresolved Freshwater Fish Family Nemacheilidae Teleostei Cypriniformes Large animal families with unresolved taxonomy are notoriously difficult to handle with respect to their biodiversity, systematics, and evolutionary history. We approach a large and taxonomically unresolved family of freshwater fishes (Nemacheilidae, >600 species) by proposing, on the basis of morph... 2/25/2022
Ramanuj Lahiri, Linda B Adams, Sangeeta Susan Thomas, Kevin Pethe Sensitivity of Mycobacterium leprae to Telacebec The treatment of leprosy is long and complex, benefiting from the development of sterilizing, rapidly-acting drugs. Reductive evolution made Mycobacterium leprae exquisitely sensitive to Telacebec, a phase 2 drug candidate for tuberculosis(.) The unprecedented potency of Telacebec against M. leprae ... 2/24/2022
Arindam Pramanik, Zexi Xu, Shazana H Shamsuddin, Yazan S Khaled, Nicola Ingram, Thomas Maisey, Darren Tomlinson, P Louise Coletta, David Jayne, Thomas A Hughes, Arwen I I Tyler, Paul A Millner Affimer Tagged Cubosomes Targeting of Carcinoembryonic Antigen Expressing Colorectal Cancer Cells Using emIn Vitroem and emIn Vivoem Models Nanomedicines, while having been approved for cancer therapy, present many challenges such as low stability, rapid clearance, and nonspecificity leading to off-target toxicity. Cubosomes are porous lyotropic liquid crystalline nanoparticles that have shown great premise as drug delivery vehicles; ho... 2/23/2022
Hadia Arzoun, Mirra Srinivasan, Mona Adam, Siji S Thomas, Bridget Lee, Alena Yarema A Systematic Review on the Management of Transfusion-Related Acute Lung Injury in Transfusion-Dependent Sickle Cell Disease The onset of respiratory distress and acute lung injury (ALI) following a blood transfusion is known as transfusion-related acute lung injury (TRALI), although its pathophysiology remains unknown. Even though sickle cell disease (SCD) has been studied for more than a century, few therapeutic and man... 2/15/2022
Hadia Arzoun, Mirra Srinivasan, Santhosh Raja Thangaraj, Siji S Thomas, Alena Yarema, Bridget Lee, Lubna Mohammed Recent Advancements in the Management of Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis A Systematic Review Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a rare multisystem autoimmune condition that causes inflammation of small and medium-sized blood vessels and is more commonly seen in the geriatric population. ANCA-associated vasculitis (AAV) is typically characterized as necrotiz... 2/14/2022
Suma S Thomas, Helia Hosseini-Nejad, Cornelia Bohne Dynamics of small molecules within the F127 PEO-PPO-PEO triblock copolymer gel and sol phases studied at the molecular scale Triplet excited states of guest molecules with different hydrophobicities were used to probe the association and dissociation dynamics of these guests with F127 micelles in the gel and sol phases. The dynamics probed was on a longer length scale than amenable with fluorescence techniques, but at a s... 2/10/2022
Marianna V Papageorge, Alison P Woods, Susanna W L de Geus, Sing Chau Ng, Michael K Paasche-Orlow, Dorry Segev, David McAneny, Kelly M Kenzik, Teviah E Sachs, Jennifer F Tseng Beyond insurance status the impact of Medicaid expansion on the diagnosis of Hepatocellular Carcinoma CONCLUSION: Medicaid expansion was not associated with earlier stage diagnoses in patients with HCC, including those with higher social vulnerability. Unlike other cancers, expanded access did not translate into higher utilization of care in HCC, suggesting barriers on a multitude of levels. 1/19/2022
Hadia Arzoun, Mirra Srinivasan, Santhosh Raja Thangaraj, Siji S Thomas, Lubna Mohammed The Progression of Chronic Myeloid Leukemia to Myeloid Sarcoma A Systematic Review Chronic myeloid leukemia (CML) is a slow-growing type of cancer that originates in the blood-forming cells of the bone marrow and is caused by a chromosomal mutation that is thought to occur spontaneously. CML could potentially lead to the development of myeloid sarcoma (MS), which is a rare neoplas... 1/17/2022
María Tejada-Casado, Razvan Ghinea, María M Perez, Henning Lübbe, Ioana S Pop-Ciutrila, Javier Ruiz-López, Luis Javier Herrera Reflectance and color prediction of dental material monolithic samples with varying thickness OBJECTIVE: To assess accuracy of reflectance reconstruction and color estimation of different dental materials with varying thicknesses using Principal Component Analysis (PCA). 1/17/2022
Malcolm Hart Squires, Cecilia G Ethun, Erin E Donahue, Jennifer H Benbow, Colin J Anderson, Megan H Jagosky, Munsa Manandhar, Joshua C Patt, Jeffrey S Kneisl, Jonathan C Salo, Joshua S Hill, William Ahrens, Roshan S Prabhu, Michael B Livingston, Nicole L Gower, McKenzie Needham, Sally J Trufan, Ryan C Fields, Bradley A Krasnick, Meena Bedi, Konstantinos Votanopoulos, Konstantinos Chouliaras, Valerie Grignol, Kevin K Roggin, Jennifer Tseng, George Poultsides, Thuy B Tran, Kenneth Cardona, J Harrison Howard Extremity Soft Tissue Sarcoma A Multi-Institutional Validation of Prognostic Nomograms CONCLUSIONS: Sarculator and MSKCC nomograms demonstrated good prognostic ability for survival and recurrence outcomes in a modern, multi-institutional validation cohort of resected primary extremity STS patients. External validation of these nomograms supports their ongoing incorporation into clinic... 1/11/2022
Marianna V Papageorge, Susanna W L de Geus, Alison P Woods, Sing Chau Ng, David McAneny, Jennifer F Tseng, Kelly M Kenzik, Teviah E Sachs The Effect of Hospital Versus Surgeon Volume on Short-Term Patient Outcomes After Pancreaticoduodenectomy a SEER-Medicare Analysis CONCLUSION: Compared with surgeon volume, hospital volume is a more significant factor in predicting short-term outcomes after PD. This suggests that a focus on resources and care pathways, in combination with volume metrics, is more likely to achieve high-quality care for patients undergoing PD acr... 1/7/2022
Marianna V Papageorge, Susanna W L de Geus, Alison P Woods, Sing Chau Ng, F Thurston Drake, Andrea Merrill, Michael R Cassidy, David McAneny, Jennifer F Tseng, Teviah E Sachs Lymphadenectomy in gallbladder adenocarcinoma Are we doing enough CONCLUSIONS: The majority of patients with gallbladder adenocarcinoma do not undergo the recommended nodal dissection, resulting in a survival disadvantage, likely due to understaging, decisions regarding adjuvant therapy and local tumor recurrence. 1/1/2022
Waseem Sous, Christina D Lupone, Megan A Harris, Ayan Mohamed, Liban Mohamed, Mary Jo Lakomski, Simone Seward, Andrea V Shaw Integrated Care Management to Improve Diabetes Outcomes in Refugee and Immigrant Patients I-Care Purpose: Refugee and immigrant patients face significant barriers to health care and are more likely to have poorly controlled chronic disease than the general U.S. population. I-Care aims to improve health equity for refugees and immigrants who face a disproportionate burden of chronic disease. Met... 12/15/2021
Marianna V Papageorge, Susanna W L de Geus, Alison P Woods, Sing Chau Ng, David McAneny, Jennifer F Tseng, Kelly M Kenzik, Teviah E Sachs The impact of upper gastrointestinal surgical volume on short term pancreaticoduodenectomy outcomes for pancreatic adenocarcinoma in the SEER-Medicare population CONCLUSION: Patients with pancreatic adenocarcinoma who are older and more medically complex benefit from undergoing surgery at high volume PD centers, independent of the operative experience of that center. 12/9/2021
Jared A Shenson, Ivana Jankovic, Hyo Jung Hong, Benjamin Weia, Lee White, Jonathan H Chen, Matthew Eisenberg Engaging Housestaff as Informatics Collaborators Educational and Operational Opportunities CONCLUSION: The council model has effectively engaged housestaff as learners, local champions, and key informatics collaborators, with positive impact for the participating members and the institution. Requiring few resources for implementation, the model should be replicable at other institutions. 12/8/2021
Francisco Carrillo-Perez, Oscar E Pecho, Juan Carlos Morales, Rade D Paravina, Alvaro Della Bona, Razvan Ghinea, Rosa Pulgar, María Del Mar Pérez, Luis Javier Herrera Applications of artificial intelligence in dentistry A comprehensive review CONCLUSIONS: The insight provided by the present work has reported outstanding results in the design of high-performance decision support systems for the aforementioned areas. The future of digital dentistry goes through the design of integrated approaches providing personalized treatments to patien... 11/29/2021
Katherine McFarlin, Siji S Thomas, Terrance Kane, Josh Buell, Nita Thomas, Abhijit Shivkumar Characteristic Features of COVID-19 Illness Among Healthcare Workers A Retrospective Analysis Background Frontline workers, who practice in a variety of settings, have been affected profoundly by the coronavirus disease 2019 (COVID-19) pandemic both professionally and personally. Due to the nature of their job responsibilities, many healthcare workers were exposed to a variety of settings to... 11/22/2021
Expert Panel on Breast Imaging, Ann Brown, Ana P Lourenco, Bethany L Niell, Beth Cronin, Elizabeth H Dibble, Maggie L DiNome, Mita Sanghavi Goel, Juliana Hansen, Samantha L Heller, Maxine S Jochelson, Baer Karrington, Katherine A Klein, Tejas S Mehta, Mary S Newell, Loren Schechter, Ashley R Stuckey, Mary E Swain, Jennifer Tseng, Daymen S Tuscano, Linda Moy ACR Appropriateness Criteria Transgender Breast Cancer Screening Breast cancer screening recommendations for transgender and gender nonconforming individuals are based on the sex assigned at birth, risk factors, and use of exogenous hormones. Insufficient evidence exists to determine whether transgender people undergoing hormone therapy have an overall lower, ave... 11/19/2021
Michael J Brenner, Jared A Shenson, Austin S Rose, Tulio A Valdez, Masayoshi Takashima, Omar G Ahmed, Philip A Weissbrod, Robert S Hong, Hamid Djalilian, Jeffrey S Wolf, Robert J Morrison, Peter L Santa Maria, Isaac D Erbele New Medical Device and Therapeutic Approvals in Otolaryngology State of the Art Review 2020 CONCLUSIONS: The Medical Devices and Drugs Committee reviewed 53 new therapeutics and 1094 devices (89 ENT, 140 anesthesia, 511 plastic and general surgery, and 354 neurology) approved in 2020. Ten drugs and 17 devices were considered relevant to the otolaryngology community. Rhinology saw significa... 11/18/2021
Chelsea R Olson, Lorena P Suarez-Kelly, Cecilia G Ethun, Rita D Shelby, Peter Y Yu, Tasha M Hughes, Marilly Palettas, Thuy B Tran, George Poultsides, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley A Krasnick, Ryan C Fields, David M King, Meena Bedi, Raphael E Pollock, Valerie P Grignol, Kenneth Cardona, J Harrison Howard Resection Status Does Not Impact Recurrence in Well-Differentiated Liposarcoma of the Extremity BACKGROUND: Well-differentiated liposarcoma (WDLPS) is a low-grade soft tissue sarcoma with a propensity for local recurrence. The necessity of obtaining microscopically free surgical margins (R0) to minimize local recurrence is not clear. This study evaluates recurrence-free survival (RFS) of extre... 11/11/2021
Aritrick Chatterjee, Crystal Mercado, Roger M Bourne, Ambereen Yousuf, Brittany Hess, Tatjana Antic, Scott Eggener, Aytekin Oto, Gregory S Karczmar Validation of Prostate Tissue Composition by Using Hybrid Multidimensional MRI Correlation with Histologic Findings Background Tissue estimates obtained by using microstructure imaging techniques, such as hybrid multidimensional (HM) MRI, may improve prostate cancer diagnosis but require histologic validation. Purpose To validate prostate tissue composition measured by using HM MRI, with quantitative histologic e... 11/9/2021
Nina G Bozhanova, Joel M Harp, Brian J Bender, Alexey S Gavrikov, Dmitry A Gorbachev, Mikhail S Baranov, Christina B Mercado, Xuan Zhang, Konstantin A Lukyanov, Alexander S Mishin, Jens Meiler Computational redesign of a fluorogen activating protein with Rosetta The use of unnatural fluorogenic molecules widely expands the pallet of available genetically encoded fluorescent imaging tools through the design of fluorogen activating proteins (FAPs). While there is already a handful of such probes available, each of them went through laborious cycles of in vitr... 11/8/2021
Cameron W Swanick, Jing Jiang, J Alberto Maldonado, Xiudong Lei, Ya-Chen Tina Shih, Abigail S Caudle, Donald P Baumann, Sharon H Giordano, Simona F Shaitelman, Shervin M Shirvani, Benjamin D Smith Differences in Time Burden across Local Therapy Strategies for Early-stage Breast Cancer CONCLUSIONS: Although Mast+Recon confers the highest inpatient and outpatient time burden, Lump+WBI carries the highest total time burden. Increased use of hypofractionation will reduce the total time burden for Lump+WBI. 11/8/2021
Melissa N Poulsen, Brian S Schwartz, Joseph Dewalle, Cara Nordberg, Jonathan S Pollak, Jennifer Silva, Carla I Mercado, Deborah B Rolka, Karen Rae Siegel, Annemarie G Hirsch Proximity to freshwater blue space and type 2 diabetes onset the importance of historical and economic context Salutogenic effects of living near aquatic areas (blue space) remain underexplored, particularly in non-coastal and non-urban areas. We evaluated associations of residential proximity to inland freshwater blue space with new onset type 2 diabetes (T2D) in central and northeast Pennsylvania, USA, usi... 11/5/2021
Curtis M Bryant, Randal H Henderson, R Charles Nichols, William M Mendenhall, Bradford S Hoppe, Carlos E Vargas, Thomas B Daniels, C Richard Choo, Rahul R Parikh, Huan Giap, Jerry D Slater, Neha Vapiwala, William Barrett, Akash Nanda, Mark V Mishra, Seungtaek Choi, Jay J Liao, Nancy P Mendenhall, Genitourinary Subcommittee of the Particle Therapy Co-Operative Group Consensus Statement on Proton Therapy for Prostate Cancer Proton therapy is a promising but controversial treatment in the management of prostate cancer. Despite its dosimetric advantages when compared with photon radiation therapy, its increased cost to patients and insurers has raised questions regarding its value. Multiple prospective and retrospective ... 11/1/2021
Sangeeta Susan Thomas, Kevin Pethe Determination of Bioenergetic Parameters in Mycobacterium ulcerans The oxidative phosphorylation (OxPhos) pathway has emerged as an attractive pathway for the development of anti-mycobacterial drugs. The OxPhos pathway is essential for ATP resynthesis and maintenance of the electrochemical transmembrane gradient. The bioenergetic parameters of the pathway such as o... 10/13/2021
Sangeeta Susan Thomas, Nitin Pal Kalia, Kevin Pethe Turbidity-Based MIC Assay and Characterization of Spontaneous Drug Resistant Mutants in Mycobacterium ulcerans Generation and characterization of drug resistant mutants is a powerful tool in antimicrobial drug discovery for identification of the molecular target of an investigational drug candidate. The method is relatively simple to be conducted in a classical microbiology laboratory. Its value has been aug... 10/13/2021
Adnan S Hussaini, Navin R Prasad, Edina Paal, Eshetu A Tefera, Sonya Malekzadeh, Jessica H Maxwell The distribution of parotid gland neoplasms in a veteran population CONCLUSION: Among our cohort of veteran patients, WT was the most common benign parotid tumor and has increased in incidence over the last two decades despite an unchanged smoking rate. 10/11/2021
Sanford L Meeks, Catherine E Mercado, Richard A Popple, Nzhde Agazaryan, Tania Kaprealian, John B Fiveash, Stephen Tenn Practical Considerations for Single Isocenter LINAC Radiosurgery of Multiple Brain Metastases The purpose of this paper is to summarize treatment guidelines for the performance of single isocenter LINAC radiosurgery of multiple brain metastases developed and used by 3 experienced centers. This article is not meant to provide consensus guidelines. Rather, this is a practical, "how we do it" r... 10/7/2021
Sinnu Susan Thomas, Jacopo Palandri, Mohsen Lakehal-Ayat, Punarjay Chakravarty, Friedrich Wolf-Monheim, Matthew B Blaschko Kinematics Design of a MacPherson Suspension Architecture Based on Bayesian Optimization Engineering design is traditionally performed by hand: an expert makes design proposals based on past experience, and these proposals are then tested for compliance with certain target specifications. Testing for compliance is performed first by computer simulation using what is called a discipline ... 10/6/2021
Shalom Sara Thomas, Ji Eom, Nak-Yun Sung, Dong-Sub Kim, Youn-Soo Cha, Kyung-Ah Kim Inhibitory effect of ethanolic extract of emAbeliophyllum distichumem leaf on 3T3-L1 adipocyte differentiation CONCLUSIONS: Altogether, the results of the present study revealed that ALE inhibits lipid accumulation and may be a potential agent for managing obesity. 10/4/2021
Francisco Carrillo-Perez, Juan Carlos Morales, Daniel Castillo-Secilla, Yésica Molina-Castro, Alberto Guillén, Ignacio Rojas, Luis Javier Herrera Non-small-cell lung cancer classification via RNA-Seq and histology imaging probability fusion CONCLUSIONS: These findings suggest that a classification model using a late fusion methodology can considerably help clinicians in the diagnosis between the aforementioned lung cancer cancer subtypes over using each source of information separately. This approach can also be applied to any cancer t... 9/23/2021
Michael S Kent, Matthew G Hartwig, Eric Vallières, Abbas E Abbas, Robert J Cerfolio, Mark R Dylewski, Thomas Fabian, Luis J Herrera, Kimble G Jett, Richard S Lazzaro, Bryan Meyers, Brian A Mitzman, Rishindra M Reddy, Michael F Reed, David C Rice, Patrick Ross, Inderpal S Sarkaria, Lana Y Schumacher, William B Tisol, Dennis A Wigle, Michael Zervos Pulmonary Open, Robotic, and Thoracoscopic Lobectomy PORTaL Study An Analysis of 5721 Cases CONCLUSIONS: RL and VATS approaches were associated with favorable perioperative outcomes compared to OL. Robotic-assisted lobectomy was also associated with a reduced length of stay and decreased conversion rate when compared to VATS. 9/17/2021
Alyssa Bilotta, Lucas R Wiegand, Kevin R Heinsimer Ureteral reconstruction for complex strictures a review of the current literature CONCLUSION: Ureteral stricture disease not amenable to pyeloplasty, ureteroureterostomy or ureteroneocystostomy offers a challenge to urologist. Careful patient selection with pre-operative assessment of renal and bladder is vital to a successful operation with minimal complications. 9/15/2021
Marianna V Papageorge, Douglas B Evans, Jennifer F Tseng Health Care Disparities and the Future of Pancreatic Cancer Care There have been tremendous advances in the diagnosis and treatment of pancreatic cancer in the past decade, yet we are failing to achieve equitable outcomes for all patient populations. Disparities exist in the incidence, diagnosis, treatment, and outcomes of patients with pancreatic cancer. Inequit... 9/13/2021
Katia Bruxvoort, Christopher F Tenggardjaja, Jeff Slezak, Jonathan C Gullett, Benjamin Broder, Claire H Park, Michael Aragones, Cheryl Mercado, Katherine Wong, Steven McLaren, Steven J Jacobsen Variation in SARS-CoV-2 molecular test sensitivity by specimen types in a large sample of emergency department patients CONCLUSION: This study provides robust evidence that patient-collected saliva and anterior nares are sensitive for SARS-CoV-2 molecular testing in emergency department settings, particularly among adults ages ≥40 years and those with multiple symptoms. Higher sensitivity of provider-collected NP/OP ... 9/3/2021
Na-Yeon Kim, Shalom Sara Thomas, Dae-Il Hwang, Ji-Hye Lee, Kyung-Ah Kim, Youn-Soo Cha Anti-Obesity Effects of emMorus albaem L and emAronia melanocarpaem in a High-Fat Diet-Induced Obese C57BL6J Mouse Model The present study investigated the synergic effect of extracts of Morus alba (MA) and Aronia melanocarpa (Michx.) (AR) against high-fat diet induced obesity. Four-week-old male C57BL/6J mice were randomly divided into five groups that were fed for 14 weeks with a normal diet (ND), high-fat diet (HD)... 8/27/2021
Jin-Seon Yook, Shalom Sara Thomas, Ashley Mulcahy Toney, Mikyoung You, Young-Cheul Kim, Zhenhua Liu, Jaekwon Lee, Soonkyu Chung Dietary Iron Deficiency Modulates Adipocyte Iron Homeostasis, Adaptive Thermogenesis, and Obesity in C57BL6 Mice CONCLUSIONS: Dietary iron deficiency deregulates iron balance in the iWAT and impairs adaptive thermogenesis, thereby escalating the diet-induced weight gain in C57BL/6 mice. 8/12/2021
Rachel M Lee, Cecilia G Ethun, Adriana C Gamboa, Michael K Turgeon, Thuy Tran, George Poultsides, Valerie Grignol, Meena Bedi, Harveshp Mogal, Callisia N Clarke, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley A Krasnick, Ryan C Fields, Shervin V Oskouei, David K Monson, Nickolas B Reimer, Shishir K Maithel, Allan Pickens, Kenneth Cardona A novel preoperative risk score to guide patient selection for resection of soft tissue sarcoma lung metastases An analysis from the United States Sarcoma Collaborative CONCLUSION: We identified four characteristics that in aggregate portend a worse OS and created a novel prognostic risk score for patients with sarcoma lung metastases. Given that patients in the high-risk group have a projected OS of <20% at 5 years, this risk score, after external validation, will... 8/10/2021
Luise I Pernar, Teviah E Sachs, Jennifer F Tseng, Donald T Hess Structuring Research Rotations to Facilitate Surgery Residents Academic Productivity CONCLUSIONS: Through establishment of dedicated research rotations, we were able to increase resident engagement in a variety of research activities. We provide a simple model for training programs seeking increased research engagement and productivity for their residents without extending training ... 8/9/2021
Luis J Herrera, Eric M Wherley, Kojo Agyabeng-Dadzie, Bhupaul Ramsuchit, Matthew A Johnston, Juan C Escalon 500 Consecutive Robotic Lobectomies for Non-Small Cell Lung Cancer Perioperative and Oncologic Outcomes CONCLUSIONS: Robotic lobectomy for lung cancer is a feasible technique for treatment of non-small cell lung cancer with low perioperative morbidity and mortality. Furthermore, excellent oncologic outcomes can be achieved with this approach. 8/5/2021
Swati A Kulkarni, Kirti Kulkarni, David Schacht, Sonya Bhole, Ingrid Reiser, Hiroyuki Abe, Jean Bao, Kevin Bethke, Nora Hansen, Nora Jaskowiak, Seema A Khan, Jennifer Tseng, Buxin Chen, Jennifer Pincus, Jeffrey Mueller, Lauren Schulte, Bazil LaBomascus, Zheng Zhang, Dan Xia, Xiaochuan Pan, Christian Wietholt, Dimple Modgil, David Lester, Li Lan, Bidur Bohara, Xiao Han High-Resolution Full-3D Specimen Imaging for Lumpectomy Margin Assessment in Breast Cancer CONCLUSIONS: The ROC curves of the VSI were higher than those of the other specimen imaging methods. Full-3D specimen imaging can improve the correlation between the main lumpectomy specimen margin status and surgical pathology. The findings from this study suggest that using the VSI device for intr... 8/1/2021
Ji Young Bang, C Mel Wilcox, Juan Pablo Arnoletti, Shajan Peter, John Christein, Udayakumar Navaneethan, Robert Hawes, Shyam Varadarajulu Validation of the Orlando Protocol for endoscopic management of pancreatic fluid collections in the era of lumen-apposing metal stents CONCLUSIONS: A structured approach integrating LAMS with selective use of plastic stents improved treatment success in patients with PFCs compared to an approach using only plastic stents. 7/31/2021
Nosayaba Osazuwa-Peters, Justin M Barnes, Somtochi I Okafor, Derian B Taylor, Adnan S Hussaini, Eric Adjei Boakye, Matthew C Simpson, Evan M Graboyes, Walter T Lee Incidence and Risk of Suicide Among Patients With Head and Neck Cancer in Rural, Urban, and Metropolitan Areas CONCLUSIONS AND RELEVANCE: The findings of this cross-sectional study suggest that suicide risk is elevated in general among patients with HNC but is significantly higher for patients residing in rural areas. Effective suicide prevention strategies in the population of patients with HNC need to acco... 7/23/2021
Cara Gallo, Suma S Thomas, Allison J Selinger, Fraser Hof, Cornelia Bohne Mechanism of a Disassembly-Driven Sensing System Studied by Stopped-Flow Kinetics We carried out steady-state and stopped-flow photophysical measurements to determine the kinetics of a discrete disassembly driven turn-on fluorescent system. On and off rates for both DimerDye1 assembly and nicotine binding were determined. Relative rates for these competing processes provide insig... 7/14/2021
Malcolm H Squires, Cecilia G Ethun, Erin E Donahue, Jennifer H Benbow, Colin J Anderson, Megan H Jagosky, Jonathan C Salo, Joshua S Hill, William Ahrens, Roshan S Prabhu, Michael B Livingston, Nicole L Gower, Mckenzie Needham, Sally J Trufan, Ryan C Fields, Bradley A Krasnick, Meena Bedi, Daniel E Abbott, Patrick Schwartz, Konstantinos Votanopoulos, Konstantinos Chouliaras, Valerie Grignol, Kevin K Roggin, Jennifer Tseng, George Poultsides, Thuy B Tran, Kenneth Cardona, J Harrison Howard A multi-institutional validation study of prognostic nomograms for retroperitoneal sarcoma CONCLUSIONS: In a diverse, modern validation cohort of patients with resected primary RPS, both Sarculator and MSK nomograms demonstrated good prognostic ability, supporting their ongoing adoption into clinical practice. 7/13/2021
Tatyana A Grushko, Virginia L Filiaci, Anthony G Montag, Marsha Apushkin, Maria J Gomez, Laura Monovich, Nilsa C Ramirez, Carlton Schwab, Joshua P Kesterson, Shelly M Seward, Michael W Method, Olufunmilayo I Olopade, Gini F Fleming, Michael J Birrer Effects of Slide Storage on Detection of Molecular Markers by IHC and FISH in Endometrial Cancer Tissues From a Clinical Trial An NRG OncologyGOG Pilot Study We performed a pilot study in anticipation of using long-aged precut formalin-fixed paraffin-embedded tissue sections stored in real-world conditions for translational biomarker studies of topoisomerase 2A (TOP2A), Ki67, and human epidermal growth factor receptor 2 (HER2) in endometrial cancer. Form... 7/5/2021
Phillip L Guichet, Jeffrey Huang, Chenyang Zhan, Alexandra Millet, Kopal Kulkarni, Chloe Chhor, Cecilia Mercado, Nancy Fefferman Incorporation of a Social Virtual Reality Platform into the Residency Recruitment Season CONCLUSION: Radiology residency applicants overall preferred a pre-interview social hosted on a social VR platform, Mozilla Hubs, compared to those hosted on CVCS. Applicants reported the use of a social VR platform reflected positively on the residency and positively impacted their decision to stro... 7/4/2021
Arun Gopinathan, Jaroslav Jerz, Jaroslav Kováčik, Tomáš Dvorák Investigation of the Relationship between Morphology and Thermal Conductivity of Powder Metallurgically Prepared Aluminium Foams Among different promising solutions, coupling closed-cell aluminium foam composite panels prepared by a powder metallurgical method with pore walls interconnected by microcracks, with low thermal conductivity phase change materials (PCMs), is one of the effective ways of increasing thermal conductiv... 7/2/2021
Herbert Chen, Jennifer F Tseng, Rabih Chaer, David A Spain, John H Stewart, Daniel Dent, Beatriz Ibáñez, Carol L Barry, Andrew T Jones, Jo Buyske Outcomes of the First Virtual General Surgery Certifying Exam of the American Board of Surgery CONCLUSIONS: The first virtual CE by the ABS was completed using available internet technology. There was high satisfaction, with the majority preferring the virtual platform. Compared to past in-person CEs, there was no difference in outcomes as measured by passing rates. These data suggest that ex... 6/29/2021
Robin E McAtee, Laura Spradley, Leah Tobey, Whitney Thomasson, Gohar Azhar, Cynthia Mercado Caregiver Burden Caregiving Workshops Have a Positive Impact on Those Caring for Individuals With Dementia in Arkansas Millions of Americans live with dementia. Caregivers of this population provide countless hours of multifaceted, complex care that frequently cause unrelenting stress which can result in immense burden. However, it is not fully understood what efforts can be made to reduce the stress among caregiver... 6/28/2021
Mitchell E Horwitz, Patrick J Stiff, Corey Cutler, Claudio Brunstein, Rabi Hanna, Richard T Maziarz, Andrew R Rezvani, Nicole A Karris, Joseph McGuirk, David Valcarcel, Gary J Schiller, Caroline A Lindemans, William Y K Hwang, Liang Piu Koh, Amy Keating, Yasser Khaled, Nelson Hamerschlak, Olga Frankfurt, Tony Peled, Irit Segalovich, Beth Blackwell, Stephen Wease, Laurence S Freedman, Einat Galamidi-Cohen, Guillermo Sanz Omidubicel vs standard myeloablative umbilical cord blood transplantation results of a phase 3 randomized study Omidubicel is an ex vivo expanded hematopoietic progenitor cell and nonexpanded myeloid and lymphoid cell product derived from a single umbilical cord blood unit. We report results of a phase 3 trial to evaluate the efficacy of omidubicel compared with standard umbilical cord blood transplantation (... 6/22/2021
Saam A Mojtahed, Nicole R Boyer, Saieesh A Rao, Thomas F Gajewski, Jennifer Tseng, Kiran K Turaga Cost-Effectiveness Analysis of Adjuvant Therapy for BRAF-Mutant Resected Stage III Melanoma in Medicare Patients CONCLUSIONS: Pembrolizumab is cost-effective at a conventional willingness-to-pay (WTP) threshold, but dabrafenib-trametinib is not. Though dabrafenib-trametinib offers incremental QALYs, optimization of drug pricing is necessary to ensure dabrafenib-trametinib is accessible at an acceptable WTP thr... 6/15/2021
Carla I Mercado, Kai McKeever Bullard, Edward W Gregg, Mohammed K Ali, Sharon H Saydah, Giuseppina Imperatore Differences in US Rural-Urban Trends in Diabetes ABCS, 1999-2018 CONCLUSIONS: Over two decades, rural U.S. adults with diabetes have had less improvement in BP and cholesterol control. In addition, rural-urban differences exist across sociodemographic groups, suggesting that efforts to narrow this divide may need to address both socioeconomic and clinical aspects... 6/15/2021
Arjen Tilstra, Florian Roth, Yusuf C El-Khaled, Claudia Pogoreutz, Nils Rädecker, Christian R Voolstra, Christian Wild Relative abundance of nitrogen cycling microbes in coral holobionts reflects environmental nitrate availability Recent research suggests that nitrogen (N) cycling microbes are important for coral holobiont functioning. In particular, coral holobionts may acquire bioavailable N via prokaryotic dinitrogen (N(2)) fixation or remove excess N via denitrification activity. However, our understanding of environmenta... 6/10/2021
Yusuf C El-Khaled, Florian Roth, Nils Rädecker, Arjen Tilstra, Denis B Karcher, Benjamin Kürten, Burton H Jones, Christian R Voolstra, Christian Wild Nitrogen fixation and denitrification activity differ between coral- and algae-dominated Red Sea reefs Coral reefs experience phase shifts from coral- to algae-dominated benthic communities, which could affect the interplay between processes introducing and removing bioavailable nitrogen. However, the magnitude of such processes, i.e., dinitrogen (N(2)) fixation and denitrification levels, and their ... 6/4/2021
Bharathnag Nagappa, Archana Ramalingam, Aayushi Rastogi, Shantanu Dubey, Sherin Sarah Thomas, Ekta Gupta, Shiv Kumar Sarin Number needed to screen to prevent progression of liver fibrosis to cirrhosis at primary health centers An experience from Delhi CONCLUSION: One-third of adults visiting urban PHCs had significant liver fibrosis. Low NNS to prevent the progression of fibrosis to cirrhosis among alcohol users and other high-risk groups, substantiates the need for screening among these groups. 5/27/2021
Yusuf C El-Khaled, Rassil Nafeh, Florian Roth, Nils Rädecker, Denis B Karcher, Burton H Jones, Christian R Voolstra, Christian Wild High plasticity of nitrogen fixation and denitrification of common coral reef substrates in response to nitrate availability Nitrogen cycling in coral reefs may be affected by nutrient availability, but knowledge about concentration-dependent thresholds that modulate dinitrogen fixation and denitrification is missing. We determined the effects of different nitrate concentrations (ambient, 1, 5, 10 μM nitrate addition) on ... 5/17/2021
Julius K Weng, Xiudong Lei, Pamela Schlembach, Elizabeth S Bloom, Simona F Shaitelman, Isidora Y Arzu, Gregory Chronowski, Tomas Dvorak, Emily Grade, Karen Hoffman, George Perkins, Valerie K Reed, Shalin J Shah, Michael C Stauder, Eric A Strom, Welela Tereffe, Wendy A Woodward, Gabriel N Hortobagyi, Kelly K Hunt, Thomas A Buchholz, Benjamin D Smith Five-Year Longitudinal Analysis of Patient-Reported Outcomes and Cosmesis in a Randomized Trial of Conventionally Fractionated Versus Hypofractionated Whole-Breast Irradiation CONCLUSIONS: Both CF-WBI and HF-WBI confer similar longitudinal PROs and physician-rated cosmesis through 5 years of follow-up, with no relevant subsets that fared better with CF-WBI. This evidence supports broad adoption of hypofractionation with boost, including in patients receiving chemotherapy ... 5/16/2021
Laura H Rosenberger, Liza M Quintana, Samantha M Thomas, Suniti N Nimbkar, Tina J Hieken, Kandice K Ludwig, Lisa K Jacobs, Megan E Miller, Kristalyn K Gallagher, Jasmine Wong, Heather B Neuman, Jennifer Tseng, Taryn E Hassinger, Tari A King, James W Jakub, Rex C Bentley, Stuart J Schnitt Limited Reporting of Histopathologic Details in a Multi-Institutional Academic Cohort of Phyllodes Tumors Time for Standardization CONCLUSION: In this academic cohort of phyllodes tumors, one or more histopathologic features were frequently omitted from the pathology report. While all features were considered by the pathologist for grading, this limited reporting reflects a lack of reporting consensus. We recommend that standar... 5/15/2021
Florian Roth, Yusuf C El-Khaled, Denis B Karcher, Nils Rädecker, Susana Carvalho, Carlos M Duarte, Luis Silva, Maria Ll Calleja, Xosé Anxelu G Morán, Burton H Jones, Christian R Voolstra, Christian Wild Nutrient pollution enhances productivity and framework dissolution in algae- but not in coral-dominated reef communities Ecosystem services provided by coral reefs may be susceptible to the combined effects of benthic species shifts and anthropogenic nutrient pollution, but related field studies are scarce. We thus investigated in situ how dissolved inorganic nutrient enrichment, maintained for two months, affected co... 5/13/2021
Amod A Sarnaik, Omid Hamid, Nikhil I Khushalani, Karl D Lewis, Theresa Medina, Harriet M Kluger, Sajeve S Thomas, Evidio Domingo-Musibay, Anna C Pavlick, Eric D Whitman, Salvador Martin-Algarra, Pippa Corrie, Brendan D Curti, Judit Oláh, Jose Lutzky, Jeffrey S Weber, James M G Larkin, Wen Shi, Toshimi Takamura, Madan Jagasia, Harry Qin, Xiao Wu, Cecile Chartier, Friedrich Graf Finckenstein, Maria Fardis, John M Kirkwood, Jason A Chesney Lifileucel, a Tumor-Infiltrating Lymphocyte Therapy, in Metastatic Melanoma CONCLUSION: Lifileucel demonstrated durable responses and addresses a major unmet need in patients with metastatic melanoma with limited treatment options after approved therapy, including the primary refractory to anti-PD-1 or PD-L1 therapy subset. 5/12/2021
David C Qian, Brent D Weinberg, Stewart G Neill, Abigail L Goodman, Jeffrey J Olson, Alfredo D Voloschin, Suresh S Ramalingam, Hui-Kuo G Shu Co-Occurrence Conundrum Brain Metastases from Lung Adenocarcinoma, Radiation Necrosis, and Gliosarcoma Non-small cell lung cancer (NSCLC) commonly presents with metastasis to the brain. When brain metastases are treated with stereotactic radiosurgery (SRS), longitudinal imaging to monitor treatment response may identify radiation necrosis, metastasis progression, and/or another primary brain malignan... 5/12/2021
Yehuda Galili, Ahmad El-Far, Jennifer Tseng, Steve Carlan Role of immunotherapy in oligometastatic nonsmall cell lung cancer The approach to metastatic lung cancer has long been focused on palliation therapy and comfort care. Recently, significant subsets of patients who suffer from a limited form of the disease have shown curative outcomes. The oligometastatic disease theory was first introduced in 1995, and since has be... 5/11/2021
Kristian Brat, Michal Svoboda, Jaromir Zatloukal, Marek Plutinsky, Eva Volakova, Patrice Popelkova, Barbora Novotna, Tomas Dvorak, Vladimir Koblizek The Relation Between Clinical Phenotypes, GOLD GroupsStages and Mortality in COPD Patients - A Prospective Multicenter Study CONCLUSION: Certain phenotypes ("Czech" or "Spanish") of COPD are associated with higher risk of death. Co-presence of multiple phenotypes (emphysematous plus cachectic plus frequent exacerbator) in a single individual was associated with amplified risk of mortality. 5/6/2021
Carla Mercado, Gloria Beckles, Yiling Cheng, Kai McKeever Bullard, Sharon Saydah, Edward Gregg, Giuseppina Imperatore Trends and socioeconomic disparities in all-cause mortality among adults with diagnosed diabetes by raceethnicity a population-based cohort study - USA, 1997-2015 CONCLUSIONS: There were substantial improvements in all-cause mortality among US adults. However, we observed SEP disparities in mortality across race/ethnic groups or for adults with and without DM despite targeted efforts to improve access and quality of care among disproportionately affected popu... 5/5/2021
Brittany Lee Roberts, Eric S Chang, Ryan J Hidalgo, Lucas R Wiegand, Allison M Wyman Vesicovaginal fistula repair at the time of colpocleisis CONCLUSION: Neglect of a vaginal pessary can lead to serious complications, indicating the importance of patient education and careful follow-up. Surgical planning is a key component in effectively managing a vesicovaginal fistula with ureteral presentation in order to preserve ureteral integrity. C... 4/28/2021
Daniel Castillo-Secilla, Juan Manuel Gálvez, Francisco Carrillo-Perez, Marta Verona-Almeida, Daniel Redondo-Sánchez, Francisco Manuel Ortuno, Luis Javier Herrera, Ignacio Rojas KnowSeq R-Bioc package The automatic smart gene expression tool for retrieving relevant biological knowledge KnowSeq R/Bioc package is designed as a powerful, scalable and modular software focused on automatizing and assembling renowned bioinformatic tools with new features and functionalities. It comprises a unified environment to perform complex gene expression analyses, covering all the needed processin... 4/19/2021
Marianna V Papageorge, Susanna W L de Geus, Jian Zheng, Alison P Woods, Sing Chau Ng, Michael R Cassidy, David McAneny, Jennifer F Tseng, Teviah E Sachs The Discordance of Clinical and Pathologic Staging in Locally Advanced Gastric Adenocarcinoma CONCLUSION: This study found a substantial discordance between clinical and pathologic staging of resectable locally advanced gastric adenocarcinoma. These data support that patients may have more advanced disease at presentation than reflected in clinical staging and may benefit from improved diagn... 4/13/2021
A H Seekings, C J Warren, S S Thomas, S Mahmood, J James, A M P Byrne, S Watson, C Bianco, A Nunez, I H Brown, S M Brookes, M J Slomka Highly pathogenic avian influenza virus H5N6 clade 2344b has a preferable host tropism for waterfowl reflected in its inefficient transmission to terrestrial poultry Highly-pathogenic avian influenza virus (HPAIV) H5N6 (clade 2.3.4.4b) incurred into Europe in late 2017 and was predominantly detected in wild birds, with very few terrestrial poultry cases. Pekin ducks directly-infected with a UK virus (H5N6-2017) were donors of infection to investigate contact tra... 4/11/2021
Shivam M Kharod, Catherine E Mercado, Christopher G Morris, Curtis M Bryant, Nancy P Mendenhall, William M Mendenhall, R Charles Nichols, Bradford S Hoppe, Xiaoying Liang, Zhong Su, Zuofeng Li, Randal H Henderson Postoperative or Salvage Proton Radiotherapy for Prostate Cancer After Radical Prostatectomy CONCLUSION: High-dose postprostatectomy proton therapy provides effective long-term biochemical control and freedom from metastasis, with low acute and long-term gastrointestinal and genitourinary toxicity. 4/8/2021
Sreekar Devarakonda, Shawn Sam Thomas, Supriya Sen, Varghese Thomas, Reka Karuppusami, Anish Jacob Cherian, Pooja Ramakant, Deepak Thomas Abraham, Paul Mazhuvanchary Jacob Sentinel Lymph Node Biopsy in Early Breast Cancer Using Methylene Blue Dye Alone a Safe, Simple, and Cost-Effective Procedure in Resource-Constrained Settings Sentinel lymph node biopsy (SLNB) is done by different techniques in clinically node-negative patients with early breast cancer. In this study, we aim to estimate the identification rates, positivity rates, cost-effectiveness, and outcomes for patients who underwent sentinel node biopsy using methyl... 4/5/2021
Lucas X Marinacci, Nino Mihatov, David A D'Alessandro, Mauricio A Villavicencio, Nathalie Roy, Yuval Raz, Sunu S Thomas Extracorporeal cardiopulmonary resuscitation ECPR survival A quaternary center analysis CONCLUSIONS: Arrest rhythm and etiology may be insufficient predictors of survival in ECPR utilization. Further multiinstitutional studies are needed to determine evidenced-based criteria for ECPR deployment. 4/2/2021
Sherif Aly, Susanna W L de Geus, Cullen O Carter, Teviah E Sachs, Donald T Hess, Jennifer F Tseng, Luise I M Pernar Impact of fellow compared to resident assistance on outcomes of minimally invasive surgery CONCLUSIONS: Surgical outcomes were similar between fellow and chief resident assistance in MIS operations, arguing that increased resident participation in basic and complex laparoscopic operations is appropriate without compromising patient safety. 3/25/2021
Eric S Chang, Ryan J Hidalgo, Lucas R Wiegand, Allison Wyman Concomitant laparoscopic and vaginal excision of duplicated collecting system CONCLUSION: Duplicated urinary collecting systems are the most common birth defect related to the urinary tract and can be frequently encountered by the pelvic surgeon. Knowledge of the presentation and workup of a suspected duplicated collecting system is important in carrying out appropriate treat... 3/24/2021
Jens Strohäker, Lisa Wiegand, Christian Beltzer, Alfred Königsrainer, Ruth Ladurner, Robert Bachmann Routine postoperative blood tests fail to reliably predict procedure-related complications after laparoscopic cholecystectomy CONCLUSIONS: Early postoperative blood tests alone show a low specificity in detecting postoperative complications after laparoscopic CCE. Their main benefit appears to be the negative predictive value, when they are normal. Routine blood testing appears to be unnecessary and should be based on the ... 3/24/2021
Juliana A Medeiros, Oscar E Pecho, María M Pérez, Francisco Carrillo-Pérez, Luis Javier Herrera, Alvaro Della Bona Influence of background color on color perception in dentistry CONCLUSIONS: The lowest AT values using a black background indicates that the use of this background allows for the evaluation of slight color differences, and should be used for challenging color differences in esthetic dentistry. This study showed the influence of the observer experience on color ... 3/24/2021
Christine L Mozer, Palak H Bhagat, Sarah A Seward, Noah R Mason, Samantha L Anderson, Maxx Byron, Leah B Peirce, Victoria Konold, Madan Kumar, Vineet M Arora, Nicola M Orlov Optimizing Oral Medication Schedules for Inpatient Sleep A Quality Improvement Intervention CONCLUSIONS: A simple, low-cost intervention of computerized provider order entry default modifications and education can increase the proportion of sleep-friendly oral antibiotic administration schedules for hospitalized children. Patient perception of sleep is impacted by multiple factors and ofte... 3/18/2021
Kathryn Hawrot, Lawrence N Shulman, Ira J Bleiweiss, Elizabeth J Wilkie, Zachary A K Frosch, Rachel C Jankowitz, Amy I Laughlin Time to Treatment Initiation for Breast Cancer During the 2020 COVID-19 Pandemic CONCLUSION: TTI was maintained among patients diagnosed and treated for breast cancer during the COVID-19 pandemic at a single large academic center. There was a decrease in patient volume, specifically in patients with in situ disease and a shift in initial therapy toward the use of preoperative ho... 3/12/2021
Ralf Weigel, Lara Wiegand, Stefanie Balzereit, Michael Galatsch International medical electives for medical students at a German university a secondary analysis of longitudinal data CONCLUSIONS: Student interest in IMEs is increasing. Universities should invest more broadly in IME opportunities for student, faculty and university enrichment. 3/8/2021
Jennifer B Permuth, Kaleena B Dezsi, Shraddha Vyas, Karla N Ali, Toni L Basinski, Ovie A Utuama, Jason W Denbo, Jason Klapman, Aamir Dam, Estrella Carballido, Dae Won Kim, Jose M Pimiento, Benjamin D Powers, Amy K Otto, Jung W Choi, Dung-Tsa Chen, Jamie K Teer, Francisca Beato, Alina Ward, Elena M Cortizas, Suzanne Y Whisner, Iverson E Williams, Andrea N Riner, Kenneth Tardif, Vic Velanovich, Andreas Karachristos, Wade G Douglas, Adrian Legaspi, Bassan J Allan, Kenneth Meredith, Manual A Molina-Vega, Philip Bao, Jamii St Julien, Kevin L Huguet, Lee Green, Folakemi T Odedina, Nagi B Kumar, Vani N Simmons, Thomas J George, Susan T Vadaparampil, Pamela J Hodul, J Pablo Arnoletti, Ziad T Awad, Debashish Bose, Kun Jiang, Barbara A Centeno, Clement K Gwede, Mokenge Malafa, Sarah M Judge, Andrew R Judge, Daniel Jeong, Mark Bloomston, Nipun B Merchant, Jason B Fleming, Jose G Trevino, None On Behalf Of The Florida Pancreas Collaborative The Florida Pancreas Collaborative Next-Generation Biobank Infrastructure to Reduce Disparities and Improve Survival for a Diverse Cohort of Patients with Pancreatic Cancer Background: Well-annotated, high-quality biorepositories provide a valuable platform to support translational research. However, most biorepositories have poor representation of minority groups, limiting the ability to address health disparities. Methods: We describe the establishment of the Florida... 3/6/2021
Susanna Wl de Geus, Alison P Woods, Marianna V Papageorge, Jian Zheng, Sing Chau Ng, David McAneny, Teviah E Sachs, Jennifer F Tseng Combined Hepatopancreaticobiliary Volume and Hepatectomy Outcomes in Hepatocellular Carcinoma Patients at Low-Volume Liver Centers CONCLUSIONS: LR outcomes at low-volume LR centers that have substantial experience with HPB cancer operations are similar to those at high-volume LR centers. Our results demonstrate that the volume to outcomes curve for HPB operations should be assessed more holistically and that patients can safely... 2/28/2021
Carmel Mercado, John Welling, Matthew Oliva, Jack Li, Reeta Gurung, Sanduk Ruit, Geoff Tabin, David Chang, Suman Thapa, David Myung Clinical Application of a Smartphone-Based Ophthalmic Camera adapter in Under-Resourced Settings in Nepal CONCLUSIONS: We found the quality of both the anterior and posterior segment images to be excellent in the clinic, the operating room, and the outreach camp settings. We found the device to be versatile and user-friendly, with a short learning curve. The Paxos Scope smartphone camera adapter may pro... 2/19/2021
Daniel Pierce, Aaron Dahmen, Cliff Davis, Lucas Wiegand Prostatic artery embolization for bladder outlet obstruction in the setting of prior posterior urethroplasty This case presents a patient with a remote history of complex posterior urethral repair related to a prior motorcycle accident who presented to the urology clinic in urinary retention with associated lower urinary tract symptoms. Due to his altered anatomy, traditional outlet procedures were deferre... 2/18/2021
Marianna V Papageorge, Susanna W L de Geus, Alison P Woods, Sing Chau Ng, Frederick T Drake, Michael R Cassidy, David B McAneny, Jennifer F Tseng, Teviah E Sachs Undertreatment of Gallbladder Cancer A Nationwide Analysis CONCLUSIONS: Re-resection for gallbladder cancer is associated with improved survival but remains underused, particularly for early-stage disease. 2/10/2021
Kevin Heinsimer, Lucas Wiegand Erectile and Ejaculatory Dysfunction After Urethroplasty PURPOSE OF THE REVIEW: The goal of this paper was to evaluate the impact on erectile and ejaculatory function after anterior and posterior urethroplasty. 2/8/2021
Teviah E Sachs, Jennifer F Tseng Landmark Series in Pancreatic Tumors Anastomotic Techniques and Route of Reconstruction CONCLUSION: While clear consensus on how best to reconstruct the anatomy after pancreaticoduodenectomy has not yet been reached, we present the following review in the hope of providing some understanding of the literature for the pancreatic surgeon. 2/7/2021
Michael R Poulson, B Aldana Blanco, Alaina D Geary, Kelly M Kenzik, David B McAneny, Jennifer F Tseng, Teviah E Sachs The role of racial segregation in treatment and outcomes among patients with hepatocellular carcinoma CONCLUSIONS: Our data illustrate that structural racism in the form racial segregation has a significant impact on racial disparities in the treatment of HCC. Urban and health policy changes can potentially reduce disparities in HCC outcomes. 2/4/2021
Andrew S Oseran, Maxwell E Afari, Conor D Barrett, Gregory D Lewis, Sunu S Thomas Beyond the stethoscope managing ambulatory heart failure during the COVID-19 pandemic There have been nearly 70 million cases of COVID-19 worldwide, with over 1.5 million deaths at the time of this publication. This global pandemic has mandated dramatic changes in healthcare delivery with a particular focus on social distancing in order to reduce viral transmission. Heart failure pat... 1/28/2021
Camilla Gomes, Patrick Tivnan, David McAneny, Jennifer F Tseng, Jaroslaw Tkacz, Teviah E Sachs Choledochal Cyst or Benign Biliary Dilation Is Resection Always Necessary CONCLUSION: A radiographic diagnosis of choledochal cyst in older adults is likely a different entity than those diagnosed in childhood. Close surveillance of these biliary duct anomalies in older adults may be a better option than resection and reconstruction with the associated risks of long-term ... 1/23/2021
Alexander Nagy, Lenka Černíková, Kateřina Kunteová, Zuzana Dirbáková, Saumya S Thomas, Marek J Slomka, Ádám Dán, Tünde Varga, Martina Máté, Helena Jiřincová, Ian H Brown A universal RT-qPCR assay for One Health detection of influenza A viruses The mutual dependence of human and animal health is central to the One Health initiative as an integrated strategy for infectious disease control and management. A crucial element of the One Health includes preparation and response to influenza A virus (IAV) threats at the human-animal interface. Th... 1/20/2021
Jens Strohäker, Lisa Wiegand, Christian Beltzer, Alfred Königsrainer, Ruth Ladurner, Anke Meier Clinical Presentation and Incidence of Anaerobic Bacteria in Surgically Treated Biliary Tract Infections and Cholecystitis (1) Background: Cholecystitis and cholangitis are among the most common diseases treated by general surgery. Gallstones lead to inflammation and bacterial infection of the biliary tract. Biliary infections can lead to live threatening bacteremia and liver abscesses. The true role of anaerobes remain... 1/16/2021
Melissa N Poulsen, Brian S Schwartz, Cara Nordberg, Joseph DeWalle, Jonathan Pollak, Giuseppina Imperatore, Carla I Mercado, Karen R Siegel, Annemarie G Hirsch Association of Greenness with Blood Pressure among Individuals with Type 2 Diabetes across Rural to Urban Community Types in Pennsylvania, USA Greenness may impact blood pressure (BP), though evidence is limited among individuals with type 2 diabetes (T2D), for whom BP management is critical. We evaluated associations of residential greenness with BP among individuals with T2D in geographically diverse communities in Pennsylvania. To addre... 1/16/2021
B S Schwartz, Jonathan Pollak, Melissa N Poulsen, Karen Bandeen-Roche, Katherine Moon, Joseph DeWalle, Karen Siegel, Carla Mercado, Giuseppina Imperatore, Annemarie G Hirsch Association of community types and features in a case-control analysis of new onset type 2 diabetes across a diverse geography in Pennsylvania CONCLUSIONS: Urban residence was associated with higher odds of type 2 diabetes than for other areas. Higher community socioeconomic deprivation in city census tracts and lower greenness in all community types were also associated with type 2 diabetes. 1/14/2021
Laura H Rosenberger, Samantha M Thomas, Suniti N Nimbkar, Tina J Hieken, Kandice K Ludwig, Lisa K Jacobs, Megan E Miller, Kristalyn K Gallagher, Jasmine Wong, Heather B Neuman, Jennifer Tseng, Taryn E Hassinger, Tari A King, James W Jakub Contemporary Multi-Institutional Cohort of 550 Cases of Phyllodes Tumors 2007-2017 Demonstrates a Need for More Individualized Margin Guidelines CONCLUSION: In current practice, many patients are managed outside of current guidelines. For the entire cohort, a wider margin width was not associated with a reduced risk of LR. We do not recommend re-excision of a negative margin for benign PT, regardless of margin width, as a progressively wider... 12/10/2020
Alberto Guillén, José Martínez, Juan Miguel Carceller, Luis Javier Herrera A Comparative Analysis of Machine Learning Techniques for Muon Count in UHECR Extensive Air-Showers The main goal of this work is to adapt a Physics problem to the Machine Learning (ML) domain and to compare several techniques to solve it. The problem consists of how to perform muon count from the signal registered by particle detectors which record a mix of electromagnetic and muonic signals. Fin... 12/8/2020
Luis Javier Herrera, Carlos José Todero Peixoto, Oresti Baños, Juan Miguel Carceller, Francisco Carrillo, Alberto Guillén Composition Classification of Ultra-High Energy Cosmic Rays The study of cosmic rays remains as one of the most challenging research fields in Physics. From the many questions still open in this area, knowledge of the type of primary for each event remains as one of the most important issues. All of the cosmic rays observatories have been trying to solve thi... 12/8/2020
Tien Anh N Tran, Armando Rosales, J Pablo Arnoletti, Jie Ouyang, Muhammad K Hasan Concomitant neuroendocrine tumor and gastrointestinal stromal tumor in a duodenal fine needle aspiration A cytologic clue for neurofibromatosis type 1 The identification of two cell populations displaying different cytologic characteristics in the same fine needle aspiration (FNA), one with an epithelioid appearance and the other spindle cell morphology, is an extremely rare phenomenon and potentially represents a source of diagnostic confusion. D... 12/6/2020
Susanna W L de Geus, Krista J Hachey, Jacob D Nudel, Sing Chau Ng, David B McAneny, Joshua D Davies, Jennifer F Tseng, Teviah E Sachs Volume of Pancreas-Adjacent Operations Favorably Influences Pancreaticoduodenectomy Outcomes at Lower Volume Pancreas Centers CONCLUSIONS: PD outcomes at low-volume centers that have experience with complex cancer operations near the pancreas are similar to PD outcomes at hospitals with high PD volume. MVH provides a model for PD outcomes to improve quality and access for patients who cannot, or choose not to, receive thei... 12/4/2020
Alena Opálková išková, Tomáš Dvorák, Tímea imonová Baranyaiová, Erik imon, Anita Eckstein Andicsová, Helena vajdlenková, Andrej Opálek, Peter Krížik, Martin Nosko Simple and Eco-Friendly Route from Agro-Food Waste to Water Pollutants Removal The current study reflects the demand to mitigate the environmental issues caused by the waste from the agriculture and food industry. The crops that do not meet the supply chain requirements and waste from their processing are overfilling landfills. The mentioned wastes contain cellulose, which is ... 12/2/2020
Katia Bruxvoort, Jeff Slezak, Runxin Huang, Bradley Ackerson, Lina S Sy, Lei Qian, Kristi Reynolds, William Towner, Zendi Solano, Cheryl Mercado, Randall Hyer, Robert Janssen, Steven J Jacobsen Association of Number of Doses With Hepatitis B Vaccine Series Completion in US Adults CONCLUSIONS AND RELEVANCE: In this study, use of the HepB-CpG vaccine was associated with hepatitis B vaccine series completion, but tailored strategies to increase completion of hepatitis B vaccine series are warranted. 11/30/2020
Neenu Kuruvilla, Rahul Rajendran, Shilpa S Thomas, Irshad Ali Km, Sheela Kurian An Unusual Presentation of Adult-Onset Stills Disease as Hemophagocytic Lymphohistiocytosis in a Male Patient Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and potentially fatal condition characterized by immune activation and multi-organ dysfunction. HLH can be inherited in an autosomal recessive fashion, but can also be secondary to infections, malignancy, immunosuppression, and autoimmune con... 11/26/2020
Moetaz El-Domyati, Wael Hosam El-Din, Walid Medhat, Michel R Ibrahim, Yasmin Khaled Carboxytherapy for striae distensae A promising modality CONCLUSIONS: CDT is an effective, promising, and simple minimally invasive procedure for improving SD with few side effects and low downtime. 11/18/2020
Hao Tang, Suma S Thomas, Luise Wolf, Palani Natarajan, Young Ho Ko, James Wilson, Kimoon Kim, Cornelia Bohne Nonlinear Dependence on Nasupsup Ions for the Binding Dynamics of Cucurbit6uril with the emtransem-1-Methyl-4-4-hydroxystyrylpyridinium Cation The binding dynamics of the trans-1-methyl-4-(4-hydroxystyryl)pyridinium cation (HSP^(+)) to cucurbit[6]uril (CB[6]) in the presence of Na^(+) cations were studied to establish the effect of the relative concentrations of the system's components (HSP^(+), CB[6], and Na^(+)) on these dynamics. The fo... 11/3/2020
Ji Eom, Shalom Sara Thomas, Nak-Yun Sung, Dong-Sub Kim, Youn-Soo Cha, Kyung-Ah Kim emAbeliophyllum distichumem Ameliorates High-Fat Diet-Induced Obesity in C57BL6J Mice by Upregulating the AMPK Pathway The use of natural compounds as anti-obesity agents has been gaining attention over the past few years. Abeliophyllum distichum Nakai is endemic to Korea. In the present study, an A. distichum leaf extract (AE) was analyzed for its anti-obesity effects in mice fed a high-fat diet. Seven-week-old mal... 11/3/2020
Barbara Aldana Blanco, Michael Poulson, Kelly M Kenzik, David B McAneny, Jennifer F Tseng, Teviah E Sachs The Impact of Residential Segregation on Pancreatic Cancer Diagnosis, Treatment, and Mortality CONCLUSIONS: Disparities in advanced-stage disease at diagnosis, surgery for localized disease, and overall survival are directly related to the degree of residential segregation, a proxy for structural racism. In searching for solutions to this problem, it is important to account for the historical... 11/2/2020
Nupur Tamhane, Brittany Roberts, Lucas Wiegand, Emad Mikhail Robotic Surgery for Urologic Deep Infiltrating Endometriosis A Review and Case Presentations Urologic involvement is seen in 1.2-3.9% of women with endometriosis. The bladder (84%) is the most common location of urinary tract endometriosis and the retro-trigone and dome of the bladder are the most frequently affected sites. Ureteral involvement is commonly extrinsic and leads to compression... 10/22/2020
Annemarie G Hirsch, April P Carson, Nora L Lee, Tara McAlexander, Carla Mercado, Karen Siegel, Nyesha C Black, Brian Elbel, D Leann Long, Priscilla Lopez, Leslie A McClure, Melissa N Poulsen, Brian S Schwartz, Lorna E Thorpe The Diabetes Location, Environmental Attributes, and Disparities Network Protocol for Nested Case Control and Cohort Studies, Rationale, and Baseline Characteristics CONCLUSIONS: The Network will provide insight into the community factors driving geographical disparities in type 2 diabetes risk and disseminate findings to stakeholders, providing guidance on policies to ameliorate geographic disparities in type 2 diabetes in the United States. 10/19/2020
Adam S Baumgarten, Kevin Heinsimer, Lucas Wiegand Robotic Posterior Urethroplasty after Complete Urethral Transection During Abdominal Perineal Resection CONCLUSIONS:: Early robotic repair of an iatrogenic posterior urethral disruption is feasible with successful short-term outcomes. This is a select and rare complication of colorectal surgery and therefore, long-term stricture free rates are yet to be determined. 10/13/2020
Shalom Sara Thomas, Youn-Soo Cha, Kyung-Ah Kim Effect of vegetable oils with different fatty acid composition on high-fat diet-induced obesity and colon inflammation CONCLUSIONS: Taken together, our data indicate that the three oils exert similar anti-obesity effects. Interestingly, compared with olive oil and SO, PO provides better protection against high-fat diet-induced colon inflammation, suggesting that PO consumption helps manage inflammation-related disea... 10/8/2020
María M Pérez, Alvaro Della Bona, Francisco Carrillo-Pérez, Diana Dudea, Oscar E Pecho, Luis Javier Herrera Does background color influence visual thresholds CONCLUSIONS: The perceptibility and acceptability thresholds in dentistry are affected by the color difference metrics and by the background color. 9/22/2020
Kathryn I Sunthankar, Kevin N Griffith, Stephanie D Talutis, Amy K Rosen, David B McAneny, Matthew H Kulke, Jennifer F Tseng, Teviah E Sachs Cancer stage at presentation for incarcerated patients at a single urban tertiary care center Patients who are incarcerated are a vulnerable patient population and may suffer from less access to routine cancer screenings compared to their non-incarcerated counterparts. Therefore, a thorough evaluation of potential differences in cancer diagnosis staging is needed. We sought to examine whethe... 9/15/2020
Rachel M Lee, Cecilia G Ethun, Mohammad Y Zaidi, Thuy B Tran, George A Poultsides, Valerie P Grignol, John H Howard, Meena Bedi, T Clark Gamblin, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley A Krasnick, Ryan C Fields, Shervin V Oskouei, David K Monson, Nickolas B Reimer, Shishir K Maithel, Kenneth Cardona A closer look at the natural history and recurrence patterns of high-grade truncalextremity leiomyosarcomas A multi-institutional analysis from the US Sarcoma Collaborative CONCLUSIONS: In our cohort, patients with LMS have a low local recurrence rate (12-15%) and modest distant recurrence rate (29-35%). However, LMS patients had no improvement in local control or long-term outcomes with radiation. The value of radiation in these patients merits further investigation. 9/6/2020
Susanna W L de Geus, Sameer Hirji, Krista J Hachey, Teviah E Sachs, Kei Suzuki, Sing Chau Ng, Scott Swanson, Virginia R Litle, Thomas D'Amico, Jennifer F Tseng Lymphadenectomy and Survival After Neoadjuvant Chemoradiation for Esophageal Adenocarcinoma Is More Better CONCLUSIONS: After neoadjuvant chemoradiation, resection of 25 or more lymph nodes was associated with longer median survival. Prospective trials are warranted to determine the optimal nodal yield after neoadjuvant chemoradiation. 9/3/2020
Kurt S Schultz, Donald T Hess, Teviah E Sachs, Jennifer F Tseng, Luise I M Pernar A Structured Mentorship Elective Deepens Personal Connections and Increases Scholarly Achievements of Senior Surgery Residents CONCLUSIONS: A structured apprenticeship rotation allowed for closer relationships with attending surgeons and increased the scholarly achievement of PGY-4 surgery residents. We provide an example of how to incorporate a successful elective rotation into the surgery curriculum that strengthens resid... 9/1/2020
Jared A Shenson, George S Liu, Joyce Farrell, Nikolas H Blevins Multispectral Imaging for Automated Tissue Identification of Normal Human Surgical Specimens CONCLUSIONS: A deep learning model using multispectral imaging outperformed a similar model and surgical residents using traditional white-light imaging at the task of classifying normal human head and neck tissue ex vivo. These results suggest that multispectral imaging can enhance surgical vision ... 8/26/2020
Michael Poulson, Alaina Geary, Chandler Annesi, Lisa Allee, Kelly Kenzik, Sabrina Sanchez, Jennifer Tseng, Tracey Dechert National Disparities in COVID-19 Outcomes between Black and White Americans CONCLUSION: Despite the initial descriptions of COVID-19 being a disease that affects all individuals, regardless of station, our data demonstrate the differential racial effects in the United States. This current pandemic reinforces the need to assess the unequal effects of crises on disadvantaged ... 8/12/2020
Kurt S Schultz, Susanna W L de Geus, Teviah E Sachs, Ryan B Morgan, Sing Chau Ng, David McAneny, Jennifer F Tseng Influence of race and sociodemographic factors on declining resection for gastric cancer A national study CONCLUSIONS: Racial and sociodemographic disparities exist in the treatment of potentially curable gastric cancer, with patients who decline recommended surgery suffering worse overall survival. 8/8/2020
Erin A Strong, Sandra H Park, Cecilia G Ethun, Bonnie Chow, David King, Meena Bedi, John Charlson, Harveshp Mogal, Susan Tsai, Kathleen Christians, Thuy B Tran, George Poultsides, Valerie Grignol, J Harrison Howard, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Darren Cullinan, Ryan C Fields, T Clark Gamblin, Kenneth Cardona, Callisia N Clarke High neutrophil-lymphocyte ratio is not independently associated with worse survival or recurrence in patients with extremity soft tissue sarcoma CONCLUSION: Tumor inflammation as measured by high pretreatment neutrophil-lymphocyte ratio was not independently associated with overall survival in patients undergoing resection for extremity soft tissue sarcomas. 8/2/2020
Jason T Wiseman, Cecilia G Ethun, Jordan M Cloyd, Rita Shelby, Lorena Suarez-Kelly, Thuy Tran, George Poultsides, Harveshp Mogal, Callisia Clarke, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley Krasnick, Ryan Fields, Kara Vande Walle, Sean Ronnekleiv-Kelly, John Harrison Howard, Kenneth Cardona, Valerie Grignol Analysis of textbook outcomes among patients undergoing resection of retroperitoneal sarcoma A multi-institutional analysis of the US Sarcoma Collaborative CONCLUSIONS: Among patients undergoing resection for RPS, failure to achieve TO is common and associated with significantly worse survival. The use of TO may inform patient expectations and serve as a measure for patient-level hospital performance. 7/23/2020
Ji Young Bang, C Mel Wilcox, Juan Pablo Arnoletti, Shyam Varadarajulu Importance of Disconnected Pancreatic Duct Syndrome in Recurrence of Pancreatic Fluid Collections Initially Drained Using Lumen-Apposing Metal Stents CONCLUSIONS: In treatment of PFCs with LAMS in patients with DPDS, it is important to replace the LAMS with indwelling plastic stents to minimize PFC recurrence and reduce morbidity. Clinicaltrials.gov no: NCT02422095. 7/20/2020
Ji Young Bang, Konrad Krall, Nirag Jhala, Charanjeet Singh, Mohamedtaki Tejani, Juan Pablo Arnoletti, Udayakumar Navaneethan, Robert Hawes, Shyam Varadarajulu Comparing Needles and Methods of Endoscopic Ultrasound-Guided Fine-Needle Biopsy to Optimize Specimen Quality and Diagnostic Accuracy for Patients With Pancreatic Masses in a Randomized Trial CONCLUSIONS: In patients with suspected pancreatic cancer, samples with the highest degree of cellularity in a single biopsy, resulting in a diagnostic accuracy of 90% of higher, were collected by fine-needle biopsy using the franseen or fork-tip needle. Clinicaltrials.gov no: NCT04085055. 7/12/2020
Stephanie D Talutis, Susanna W L de Geus, Alik Farber, Scott R Levin, Thomas W Cheng, Teviah E Sachs, Jennifer F Tseng, Jeffrey J Siracuse Contemporary Analysis of Senior Level Case Volume Variation between Traditional Vascular Surgery Fellows and Integrated Vascular Surgery Chief Residents CONCLUSIONS: Although both pathways graduate trainees with a similar overall surgical experience, 5 + 2 trainees log significantly more "Senior" cases. Further studies investigating potential variation in operative autonomy between both pathways are necessary. 7/10/2020
Sangeeta S Thomas, Nitin Pal Kalia, Marie-Thérèse Ruf, Gerd Pluschke, Kevin Pethe Toward a Single-Dose Cure for Buruli Ulcer A single dose of Q203 (Telacebec), a phase 2 clinical candidate for tuberculosis, eradicates Mycobacterium ulcerans in a mouse model of Buruli ulcer infection without relapse up to 19 weeks posttreatment. Clinical use of Q203 may dramatically simplify the clinical management of Buruli ulcer, a negle... 7/8/2020
Sherif Aly, Stephanie D Talutis, Aaron P Richman, Donald T Hess, David McAneny, Jennifer F Tseng, F Thurston Drake The Boston Medical Center Coronavirus Disease 2019 COVID-19 Procedure Team Optimizing the surgeons role in pandemic care at a safety-net hospital CONCLUSION: Procedural complication rate was less than rates reported in the literature. The team saved approximately 192 hours of work that could be redirected to other patient care needs. In times of crisis, redeployment of surgeons (who arguably have the most procedural experience) into procedura... 7/7/2020
Timothy Dignam, James Hodge, Stella Chuke, Carlos Mercado, Adrienne S Ettinger, W Dana Flanders Use of the CUSUM and Shewhart control chart methods to identify changes of public health significance using childhood blood lead surveillance data CONCLUSION: The modified cumulative summary/Shewhart algorithm provides a framework for enhanced blood lead surveillance by identifying changes in the proportion of children with BLLs >=5 µg/dl. The algorithm has the potential to alert public health officials to changes requiring further important p... 7/2/2020
Jörg Bohlen, Tomáš Dvořák, Vlastimil lechta, Vendula lechtová Resolving an unnoticed diversity within the Schistura robertsi species complex Teleostei Nemacheilidae using molecules and morphology The Schistura robertsi species complex is a group of freshwater fish inhabiting streams in southeast Myanmar as well as in western and southern Thailand. In southern Thailand, the distribution exceeds the biogeographically important 'Surat Thani - Krabi line'. The complex is believed to include five... 6/21/2020
Michael P Recht, Nancy R Fefferman, Mark E Bittman, Bari Dane, Jan Fritz, Jason C Hoffmann, Joseph Hood, Cecilia L Mercado, Sonia Mahajan, Monica M Sheth Preserving Radiology Resident Education During the COVID-19 Pandemic The Simulated Daily Readout CONCLUSION: The development of the SDR provided an effective method of preserving the educational value of the daily readout experience of radiology residents, despite severe decreases in imaging exam volume and case mix diversity during the Coronavirus Disease 2019 pandemic. 6/20/2020
Sarah B Gitto, Jordan M Beardsley, Sai Preethi Nakkina, Jeremiah L Oyer, Kathryn A Cline, Sally A Litherland, Alicja J Copik, Amr S Khaled, Na'im Fanaian, J Pablo Arnoletti, Deborah A Altomare Identification of a novel IL-5 signaling pathway in chronic pancreatitis and crosstalk with pancreatic tumor cells CONCLUSIONS: Chronic inflammation induces increased pancreatic cancer progression and immune cells such as eosinophils are attracted to areas of fibrosis. Results suggest that IL-5 in the pancreatic compartment stimulates increased IL-5Rα on ductal tumor cells to increase pancreatic tumor motility. ... 6/20/2020
Shalom Sara Thomas, Youn-Soo Cha, Kyung-Ah Kim Perilla Oil Alleviates High-Fat Diet-Induced Inflammation in the Colon of Mice by Suppressing Nuclear Factor-Kappa B Activation This study aimed to evaluate the effect of perilla oil (PO) on high-fat diet (HD)-induced colonic inflammation. Male C57BL/6J mice (5 weeks old) were divided into four groups: normal diet, HD, HD supplemented with fish oil (FO), and HD supplemented with PO, and were fed experimental diets for 16 wee... 6/20/2020
Mayya Volodarskaya, A Blake Tucker, Jennifer Tseng Medical Student Research in Surgery From Abstract Presentation to Publication CONCLUSIONS: Forty-six percent of medical student abstract presentations at the ACS Clinical Congress were converted to peer-reviewed publications. While it is encouraging that the ACS Clinical Congress is a productive forum to showcase medical student scholarly activity, more can be done to encoura... 6/17/2020
Hisham Mehanna, John C Hardman, Jared A Shenson, Ahmad K Abou-Foul, Michael C Topf, Mohammad AlFalasi, Jason Y K Chan, Pankaj Chaturvedi, Velda Ling Yu Chow, Andreas Dietz, Johannes J Fagan, Christian Godballe, Wojciech Golusiński, Akihiro Homma, Sefik Hosal, N Gopalakrishna Iyer, Cyrus Kerawala, Yoon Woo Koh, Anna Konney, Luiz P Kowalski, Dennis Kraus, Moni A Kuriakose, Efthymios Kyrodimos, Stephen Y Lai, C Rene Leemans, Paul Lennon, Lisa Licitra, Pei-Jen Lou, Bernard Lyons, Haitham Mirghani, Anthonny C Nichols, Vinidh Paleri, Benedict J Panizza, Pablo Parente Arias, Mihir R Patel, Cesare Piazza, Danny Rischin, Alvaro Sanabria, Robert P Takes, David J Thomson, Ravindra Uppaluri, Yu Wang, Sue S Yom, Yi-Ming Zhu, Sandro V Porceddu, John R de Almeida, Chrisian Simon, F Christopher Holsinger Recommendations for head and neck surgical oncology practice in a setting of acute severe resource constraint during the COVID-19 pandemic an international consensus The speed and scale of the global COVID-19 pandemic has resulted in unprecedented pressures on health services worldwide, requiring new methods of service delivery during the health crisis. In the setting of severe resource constraint and high risk of infection to patients and clinicians, there is a... 6/15/2020
Sarah Rhea, Kasey Jones, Stacy Endres-Dighe, Breda Munoz, David J Weber, Rainer Hilscher, Jennifer MacFarquhar, Emily Sickbert-Bennett, Lauren DiBiase, Ashley Marx, James Rineer, James Lewis, Georgiy Bobashev, CDC MInD-Healthcare Network Modeling inpatient and outpatient antibiotic stewardship interventions to reduce the burden of Clostridioides difficile infection in a regional healthcare network Antibiotic exposure can lead to unintended outcomes, including drug-drug interactions, adverse drug events, and healthcare-associated infections like Clostridioides difficile infection (CDI). Improving antibiotic use is critical to reduce an individual's CDI risk. Antibiotic stewardship initiatives ... 6/12/2020
Jennifer Tseng How Has COVID-19 Affected the Costs of the Surgical Fellowship Interview Process CONCLUSIONS: The COVID-19 public health crisis has had a significant impact on surgical education, including how selection is conducted. Virtual recruitment has the potential for cost savings but should continue to be refined. This is an opportune time to innovate and rethink how to recruit prospect... 6/9/2020
Jared A Shenson, Stephen Marcott, Karuna Dewan, Yu-Jin Lee, Edward R Mariano, Davud B Sirjani Utility of videolaryngoscopy for diagnostic and therapeutic interventions in head and neck surgery BACKGROUND: Videolaryngoscopy is commonly used by anesthesiologists to manage difficult airways. Recently otolaryngologists have reported use in select procedures; to date there is limited evaluation in head and neck surgery. 6/8/2020
Susanna W L de Geus, Alik Farber, Scott Levin, Sarah J Carlson, Thomas W Cheng, Jennifer F Tseng, Jeffrey J Siracuse Perioperative Outcomes of Carotid Interventions in Octogenarians CONCLUSIONS: Outcomes of CEA and CAS were similar in octogenarians. Risk factors for worse intervention outcomes were identified, which may guide risk-benefit discussions and shared decision-making. 6/7/2020
Laura H Rosenberger, Samantha M Thomas, Suniti N Nimbkar, Tina J Hieken, Kandice K Ludwig, Lisa K Jacobs, Megan E Miller, Kristalyn K Gallagher, Jasmine Wong, Heather B Neuman, Jennifer Tseng, Taryn E Hassinger, James W Jakub Germline Genetic Mutations in a Multi-center Contemporary Cohort of 550 Phyllodes Tumors An Opportunity for Expanded Multi-gene Panel Testing CONCLUSIONS: Very few women with PT undergo germline testing; however, in those selected for testing, a deleterious mutation was identified in ~ 10%. Multigene testing of a PT cohort would present an opportunity to discover the true incidence of germline mutations in PT patients. 6/7/2020
Darryl Schuitevoerder, Charles C Vining, Jennifer Tseng Adjuvant Therapy for Cutaneous Melanoma This article presents the current data supporting adjuvant therapy for patients with cutaneous melanoma. With the recent development of novel immunotherapy agents as well as targeted therapy, there are strong data to support the use of these therapies in patients at high risk of developing recurrent... 6/3/2020
Timothy Feeney, Christine Park, Frederick Godley, Michael Cassidy, Teviah Sachs, David McAneny, Jennifer F Tseng, Frederick Thurston Drake Provider-patient Language Discordance and Cancer Operations Outcomes from a Single Center Linked to a State Vital Statistics Registry CONCLUSIONS: We found no association between language and outcomes after cancer operations. This lack of difference may reflect local efficacy at treating non-English-speaking patients, and health systems with fewer services for LEP patients might show different results. 6/1/2020
Weiming Xiang, Hoang-Dung Tran, Xiaodong Yang, Taylor T Johnson Reachable Set Estimation for Neural Network Control Systems A Simulation-Guided Approach The vulnerability of artificial intelligence (AI) and machine learning (ML) against adversarial disturbances and attacks significantly restricts their applicability in safety-critical systems including cyber-physical systems (CPS) equipped with neural network components at various stages of sensing ... 5/27/2020
Jennifer Tseng Learning theories and principles in surgical education and technical learning What is important to think about in surgical education and technical skills training? Technical skills training is grounded in social cognitive theory and the concepts of modeling and self-efficacy. Cognitive and nontechnical learning is critical to supplement the overall proficiency of the surgical... 5/23/2020
Charles C Vining, Oliver S Eng, Melissa E Hogg, Darryl Schuitevoerder, Rebecca S Silverman, Katharine A Yao, David J Winchester, Kevin K Roggin, Mark S Talamonti, Mitchell C Posner, Kiran K Turaga, Jennifer Tseng Virtual Surgical Fellowship Recruitment During COVID-19 and Its Implications for ResidentFellow Recruitment in the Future CONCLUSIONS: Current circumstances related to the COVID-19 pandemic require fellowship programs to adapt and conduct virtual interviews. Our report describes the successful implementation of a virtual interview process. This report describes the technical steps and pitfalls of organizing such an int... 5/20/2020
Adnan S Hussaini, Christine M Clark, Atur A Patel, Mark E Russo, Stanley H Chia, Bruce J Davidson, Sonya Malekzadeh Management of Adult Inpatient Otolaryngologic Consultations During the COVID-19 Pandemic A Proposed Tier-Based Triage System The coronavirus disease 2019 (COVID-19) pandemic has placed tremendous strain on health care systems, leading to unprecedented challenges and obstacles in the delivery of patient care. Otolaryngologists are frequently called on for inpatient consultations for an array of pathologies, ranging from ch... 5/20/2020
Adnan S Hussaini, Christine M Clark, Timothy R DeKlotz Perioperative Considerations in Endoscopic Skull Base Surgery PURPOSE OF THE REVIEW: Present an overview of perioperative considerations specific to endoscopic skull base surgery necessary to maximize successful outcomes. 5/19/2020
Vinay Prabhu, Joanne M Rispoli, Chloe M Chhor, Cecilia L Mercado, Nancy R Fefferman Assessing the impact of an orientation week on acclimation to radiology residency CONCLUSION: A weeklong orientation program free of clinical duties was valued by residents and contributed to acclimation to new responsibilities, education, and social cohesion. 5/11/2020
Moetaz El-Domyati, Wael Hosam El-Din, Walid Medhat, Michel R Ibrahim, Yasmin Khaled The use of Carboxytherapy alone or in combination with fractional COsub2sub laser for facial rejuvenation A split-face comparative study CONCLUSION: Carboxytherapy is an easy, safe, simple, and a relatively effective method for facial rejuvenation with minimal downtime. Better results were achieved when used in combination with fractional CO(2) laser. 5/8/2020
Xinwei Hua, Polly A Newcomb, Jessica Chubak, Rachel C Malen, Rebecca Ziebell, Aruna Kamineni, Lee-Ching Zhu, Melissa P Upton, Michelle A Wurscher, Sushma S Thomas, Hana Newman, Sheetal Hardikar, Andrea N Burnett-Hartman Associations between molecular characteristics of colorectal serrated polyps and subsequent advanced colorectal neoplasia CONCLUSION: Our results suggest that BRAF-mutant and CIMP-high serrated polyps are not associated with subsequent advanced colorectal neoplasia. Among SSA/Ps, MLH1 methylation may be an important marker to identify high-risk CRC precursors. 5/3/2020
Robert H Press, Sarah L Shafer, Renjian Jiang, Zachary S Buchwald, Mustafa Abugideiri, Sibo Tian, Tiffany M Morgan, Madhusmita Behera, Soma Sengupta, Alfredo D Voloschin, Jeffrey J Olson, Shaakir Hasan, Deborah T Blumenthal, Walter J Curran, Bree R Eaton, Hui-Kuo G Shu, Jim Zhong Optimal timing of chemoradiotherapy after surgical resection of glioblastoma Stratification by validated prognostic classification CONCLUSIONS: The current data provide insight into the optimal timing of CRT in patients with glioblastoma and describe RPA class-specific outcomes. In general, short delays beyond 5 weeks did not negatively affect outcomes, whereas early initiation before 3 weeks may be detrimental. 4/29/2020
Meghan Cooper, Lucas Wiegand An unusual variant of Zinner syndrome with ureteral ectopia from an atrophied supernumerary kidney This case presents an unusual variation of Zinner syndrome with a patient found to have an ectopic ureteral insertion of the seminal vesicle from a supernumerary pelvic kidney and complete duplication of the ipsilateral, otherwise normal renal unit. The case offers an interesting variant of a previo... 4/24/2020
Sammy Moussly, Jacqueline Kropf, Nawid Sarwari, Jose Sarriera, Steve Carlan, Mario Madruga Successful Use of Adjunctive Red Blood Cell Exchange Therapy for Treatment of an Acute Hemolytic Reaction After ABO-Incompatible Red Blood Cell Transfusion An acute hemolytic transfusion reaction is a potentially fatal complication resulting from the transfusion of mismatched blood products. Symptoms vary from mild to severe depending on how much incompatible antigen was transfused and the nature of the recipient's antibodies. There is no consensus agr... 4/18/2020
Michael C Topf, Jared A Shenson, F Christopher Holsinger, Samuel H Wald, Lisa J Cianfichi, Eben L Rosenthal, John B Sunwoo Framework for prioritizing head and neck surgery during the COVID-19 pandemic The COVID-19 pandemic has placed an extraordinary demand on the United States health care system. Many institutions have canceled elective and non-urgent procedures to conserve resources and limit exposure. While operational definitions of elective and urgent categories exist, there is a degree of s... 4/17/2020
Denis B Karcher, Florian Roth, Susana Carvalho, Yusuf C El-Khaled, Arjen Tilstra, Benjamin Kürten, Ulrich Struck, Burton H Jones, Christian Wild Nitrogen eutrophication particularly promotes turf algae in coral reefs of the central Red Sea While various sources increasingly release nutrients to the Red Sea, knowledge about their effects on benthic coral reef communities is scarce. Here, we provide the first comparative assessment of the response of all major benthic groups (hard and soft corals, turf algae and reef sands-together acco... 4/11/2020
Dao M Nguyen, Inderpal S Sarkaria, Chao Song, Rishindra M Reddy, Nestor Villamizar, Luis J Herrera, Lu Shi, Emelline Liu, David Rice, Daniel S Oh Clinical and economic comparative effectiveness of robotic-assisted, video-assisted thoracoscopic, and open lobectomy CONCLUSIONS: During the study period, the utilization of RL increased substantially and was associated with improved perioperative outcomes compared with VL and OL. When annual hospital volume was >25 cases, these clinical advantages persisted and there was no significant cost difference between RL,... 4/11/2020
Jennifer F Tseng We are All Asian Society of Asian Academic Surgeons Presidential Address This 2019 Presidential Address for the Society of Asian Academic Surgeons was delivered on September 27, 2019. Using anecdotes from her upbringing, Dr. Jennifer Tseng offers a visionary perspective on belonging and inclusivity in academic surgery. She concludes with practical strategies for success ... 4/9/2020
Jörg Bohlen, Tomáš Dvořák, Vlastimil lechta, Vendula lechtová Sea water shaping the freshwater biota Hidden diversity and biogeographic history in the Paracanthocobitis zonalternans species complex Teleostei Nemacheilidae in western Southeast Asia Western Southeast Asia is hosting one of the world's most diverse faunas, and one of the reasons for this huge diversity is the complex geologic past of the area, increasing the frequency of isolation and expansion events over evolutionary time scale. As an example case, the present study reveals th... 4/6/2020
Rita D Shelby, Lorena P Suarez-Kelly, Peter Y Yu, Tasha M Hughes, Cecilia G Ethun, Thuy B Tran, George Poultsides, David M King, Meena Bedi, Harveshp Mogal, Callisia Clarke, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley A Krasnick, Ryan C Fields, Raphael E Pollock, J Harrison Howard, Kenneth Cardona, Valerie Grignol Neoadjuvant radiation improves margin-negative resection rates in extremity sarcoma but not survival CONCLUSION: In this large study, radiotherapy improved limb salvage rates and decreased local recurrences. Receipt of NAR achieves more margin-negative resections however this did not improve local recurrence or survival rates over. 4/2/2020
Raffit Hassan, George R Blumenschein, Kathleen N Moore, Alessandro D Santin, Hedy L Kindler, John J Nemunaitis, Shelly M Seward, Anish Thomas, Stella K Kim, Prabhu Rajagopalan, Annette O Walter, Dirk Laurent, Barrett H Childs, Nenad Sarapa, Cem Elbi, Johanna C Bendell First-in-Human, Multicenter, Phase I Dose-Escalation and Expansion Study of Anti-Mesothelin Antibody-Drug Conjugate Anetumab Ravtansine in Advanced or Metastatic Solid Tumors CONCLUSION: Anetumab ravtansine exhibited a manageable safety and favorable pharmacokinetic profile with encouraging preliminary antitumor activity in heavily pretreated patients with mesothelin-expressing solid tumors. The results allowed for the determination of recommended doses, schedules, and p... 3/28/2020
Jessica H Maxwell, James A Randall, Sarah M Dermody, Adnan S Hussaini, Hamsini Rao, Ajay S Nathan, Sonya Malekzadeh, Jamie R Litvack Gender and compensation among surgical specialties in the Veterans Health Administration CONCLUSION: Female gender significantly predicted lower salary among VAMC surgeons, however within each surgical specialty, there was no significant gender pay gap. 3/19/2020
Meena Bedi, Cecilia G Ethun, John Charlson, Thuy B Tran, George Poultsides, Valerie Grignol, J Harrison Howard, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Darren Cullinan, Ryan C Fields, Kenneth Cardona, David M King Is a Nomogram Able to Predict Postoperative Wound Complications in Localized Soft-tissue Sarcomas of the Extremity CONCLUSIONS: We found that age, BMI, tumor location, and timing of radiation are associated with the risk of wound complications. Based on these factors, a validated nomogram has been established that can provide an individualized prediction of wound complications in patients with a resected soft-ti... 3/14/2020
Arjen Tilstra, Yusuf C El-Khaled, Florian Roth, Nils Rädecker, Claudia Pogoreutz, Christian R Voolstra, Christian Wild Publisher Correction Denitrification Aligns with Nsub2sub Fixation in Red Sea Corals An amendment to this paper has been published and can be accessed via a link at the top of the paper. 3/8/2020
Carlo J Mercado, Xiaochun Wang, Paul R Grimm, Paul A Welling, Yen-Pei C Chang Identification and characterization of alternative STK39 transcripts within human and mouse kidneys reveals species-specific regulation of blood pressure STK39 encodes a serine threonine kinase, SPAK, which is part of a multi-kinase network that determines renal Na^(+) reabsorption and blood pressure (BP) through regulation of sodium-chloride co-transporters in the kidney. Variants within STK39 are associated with susceptibility to essential hyperten... 2/29/2020
Khaled Al-Tarrah, Tarek Ashour, Rajashankar Rao, Sukhbir Rayatt, Sunil S Thomas Massive Localized Abdominal Lymphedema Treatment Challenges Massive localized lymphedema of the abdomen is a rare condition resulting from a neglected lower abdominal pannus associated with significant disability and morbidity. Compared to other surgical procedures, postbariatric surgery is usually considered a financial drain. In the United Kingdom, this re... 2/26/2020
Susanna W L de Geus, Teviah E Sachs, Jennifer F Tseng Big Data vs Clinical Trials in HPB Surgery Randomized controlled clinical trials (RCTs) are at the heart of "evidence-based" medicine. However, in surgical practice, RCTs remain uncommon. Conducting well-designed RCTs for surgical procedures is often challenged by inadequate recruitment accrual, blinding, or standardization of the surgical p... 2/21/2020
Anita Puranik, Marek J Slomka, Caroline J Warren, Saumya S Thomas, Sahar Mahmood, Alexander M P Byrne, Andrew M Ramsay, Paul Skinner, Samantha Watson, Helen E Everett, Alejandro Núñez, Ian H Brown, Sharon M Brookes Transmission dynamics between infected waterfowl and terrestrial poultry Differences between the transmission and tropism of H5N8 highly pathogenic avian influenza virus clade 2344a among ducks, chickens and turkeys H5N8 highly-pathogenic avian influenza viruses (HPAIVs, clade 2.3.4.4) have spread globally via migratory waterfowl. Pekin ducks infected with a UK virus (H5N8-2014) served as the donors of infection in three separate cohousing experiments to attempt onward transmission chains to sequentially introd... 2/15/2020
Benjamin D Smith, Xiudong Lei, Kevin Diao, Ying Xu, Yu Shen, Grace L Smith, Sharon H Giordano, Sarah M DeSnyder, Kelly K Hunt, Mediget Teshome, Reshma Jagsi, Simona F Shaitelman, Susan K Peterson, Cameron W Swanick Effect of Surgeon Factors on Long-Term Patient-Reported Outcomes After Breast-Conserving Therapy in Older Breast Cancer Survivors CONCLUSIONS: Specialized surgical oncology training is associated with improved long-term patient-reported outcomes. These findings underscore the value of specialized training and may be useful to patients choosing their care team. 1/10/2020
Juan M Galvez, Daniel Castillo-Secilla, Luis J Herrera, Olga Valenzuela, Octavio Caba, Jose C Prados, Francisco M Ortuno, Ignacio Rojas Towards Improving Skin Cancer Diagnosis by Integrating Microarray and RNA-Seq Datasets Many clinical studies have revealed the high biological similarities existing among different skin pathological states. These similarities create difficulties in the efficient diagnosis of skin cancer, and encourage to study and design new intelligent clinical decision support systems. In this sense... 12/25/2019
J Crossley, A S Hussaini, H J Kim, M Hoa Mnires disease clinical subtypes in a population from the USA CONCLUSION: The distribution of unilateral Ménière's disease subtypes in this US population was different from that observed in a European population. 12/21/2019
Arjen Tilstra, Yusuf C El-Khaled, Florian Roth, Nils Rädecker, Claudia Pogoreutz, Christian R Voolstra, Christian Wild Denitrification Aligns with Nsub2sub Fixation in Red Sea Corals Denitrification may potentially alleviate excess nitrogen (N) availability in coral holobionts to maintain a favourable N to phosphorous ratio in the coral tissue. However, little is known about the abundance and activity of denitrifiers in the coral holobiont. The present study used the nirS marker... 12/21/2019
James R Howe, Nipun B Merchant, Claudius Conrad, Xavier M Keutgen, Julie Hallet, Jeffrey A Drebin, Rebecca M Minter, Terry C Lairmore, Jennifer F Tseng, Herbert J Zeh, Steven K Libutti, Gagandeep Singh, Jeffrey E Lee, Thomas A Hope, Michelle K Kim, Yusuf Menda, Thorvardur R Halfdanarson, Jennifer A Chan, Rodney F Pommier The North American Neuroendocrine Tumor Society Consensus Paper on the Surgical Management of Pancreatic Neuroendocrine Tumors This manuscript is the result of the North American Neuroendocrine Tumor Society consensus conference on the surgical management of pancreatic neuroendocrine tumors from July 19 to 20, 2018. The group reviewed a series of questions of specific interest to surgeons taking care of patients with pancre... 12/20/2019
Nupur Tamhane, Lucas Wiegand, Emad Mikhail Robotic excision of deep infiltrating endometriosis at the uretero-vesical junction CONCLUSION:: Deep infiltrating endometriosis can be present in normal looking pelvis. In patients with deep infiltrating endometriosis of the bladder, bimodal visualization might be needed to delineate the extent of the disease. 12/19/2019
Vinod Arora, Rajan Vijayaraghavan, Rakhi Maiwall, Amrish Sahney, Sherin Sarah Thomas, Rehmat Ali, Priyanka Jain, Guresh Kumar, Shiv Kumar Sarin Paracentesis-Induced Circulatory Dysfunction With Modest-Volume Paracentesis Is Partly Ameliorated by Albumin Infusion in Acute-on-Chronic Liver Failure CONCLUSIONS: PICD is common and develops even with MVP in ACLF patients. Albumin infusion decreases the incidence of PICD and mortality in patients with ACLF. Clinical trial identifier: NCT02467348. 12/19/2019
Alana A Lewin, Cecilia L Mercado Atypical Ductal Hyperplasia and Lobular Neoplasia Update and Easing of Guidelines OBJECTIVE. Atypical ductal hyperplasia (ADH), atypical lobular hyperplasia (ALH), and lobular carcinoma in situ (LCIS) are among high-risk lesions that have been previously recommended for surgical excision when diagnosed on core needle biopsy. Recent studies have examined whether imaging surveillan... 12/12/2019
Shilpa Sharma, Sunu S Thomas Management of Heart Failure and Cardiogenic Shock in Pregnancy PURPOSE OF REVIEW: While the prognosis of peripartum cardiomyopathy (PPCM) is generally more favorable than other cardiomyopathies, PPCM can be associated with cardiogenic shock and significant maternal morbidity in young women. The management of a pregnant woman in cardiogenic shock necessitates co... 12/11/2019
Sophie Seward, Joyce Ramos, Claire Drummond, Angela Dalleck, Bryant Byrd, Mackenzie Kehmeier, Lance Dalleck Inter-Individual Variability in Metabolic Syndrome Severity Score and VOsub2submax Changes Following Personalized, Community-Based Exercise Programming This study sought to examine the effectiveness of a personalized, community-based exercise program at reducing MetS severity and consequently Type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) risk. One-hundred and fifty physically inactive participants (aged 18-83 years) were randomiz... 12/11/2019
Wei Yu, Chengyi Zheng, Fagen Xie, Wansu Chen, Cheryl Mercado, Lina S Sy, Lei Qian, Sungching Glenn, Hung F Tseng, Gina Lee, Jonathan Duffy, Michael M McNeil, Matthew F Daley, Brad Crane, Huong Q McLean, Lisa A Jackson, Steven J Jacobsen The use of natural language processing to identify vaccine-related anaphylaxis at five health care systems in the Vaccine Safety Datalink CONCLUSIONS: The current study demonstrated the potential to apply rule-based NLP algorithms to clinical notes to identify anaphylaxis cases. Increasing the size of training data, including clinical notes from all participating study sites in the training data, and preprocessing the clinical notes t... 12/5/2019
Peter J Hoskin, Kirsten Hopkins, Vivek Misra, Tanya Holt, Rhona McMenemin, Danny Dubois, Fiona McKinna, Bernadette Foran, Krishnaswamy Madhavan, Carol MacGregor, Andrew Bates, Noelle O'Rourke, Jason F Lester, Tim Sevitt, Daniel Roos, Sanjay Dixit, Gillian Brown, Seonaid Arnott, Sharon Shibu Thomas, Sharon Forsyth, Sandy Beare, Krystyna Reczko, Allan Hackshaw, Andre Lopes Effect of Single-Fraction vs Multifraction Radiotherapy on Ambulatory Status Among Patients With Spinal Canal Compression From Metastatic Cancer The SCORAD Randomized Clinical Trial CONCLUSIONS AND RELEVANCE: Among patients with malignant metastatic solid tumors and spinal canal compression, a single radiotherapy dose, compared with a multifraction dose delivered over 5 days, did not meet the criterion for noninferiority for the primary outcome (ambulatory at 8 weeks). However,... 12/4/2019
Kathy Lue, Kevin Heinsimer, SriGita K Madiraju, Drew Rideout, Lucas Wiegand Urologic trauma from vaginal dilation for congenital vaginal stenosis A newly-described and challenging complication Vaginal dilation is first line therapy for vaginal agenesis. No major urologic complications have even been described. We present the management and successful outcome of immediate repair for urethral trauma in a patient with history of congenital anomalies managed with vaginal dilation. Proper expo... 12/3/2019
Igor Richter, Tomas Jirasek Eva Cermakova Jiri Bartos Tomas Büchler Josef Dvorak Expression and prognostic significance of programmed death-ligand 1 PD-L1 in Merkel cell carcinoma CONCLUSIONS: PD-L1 positivity was found in 61.5% of patients with MCC. No prognostic significance of PD-L1 expression for OS was demonstrated. 12/2/2019
Susanna W L de Geus, Alaina D Geary, Nkiruka Arinze, Sing Chau Ng, Cullen O Carter, Teviah E Sachs, Jason F Hall, Donald T Hess, Jennifer F Tseng, Luise I M Pernar Resident involvement in minimally-invasive vs open procedures CONCLUSIONS: The results of this study suggest that resident participation has a similar impact on surgical outcomes during laparoscopic and open surgery, and is generally safe. 11/15/2019
Grant M Brady, Donald M Truxillo, David M Cadiz, Jennifer R Rineer, David E Caughlin, Todd Bodner Opening the black box Examining the nomological network of work ability and its role in organizational research The aging of the industrialized workforce has spurred research on how to support people working later in life. Within this context, the concept of work ability, or an employee's ability to continue working in their job, has been introduced as an explanatory mechanism for understanding employee disab... 10/25/2019
Jennifer Tseng, Mitchell C Posner For Gastroesophageal Junction Cancers, Does an Esophageal or Gastric Surgical Approach Offer Better Perioperative and Oncologic Outcomes CONCLUSIONS: The proximal and distant extent of the tumor based on Siewert type classification greatly influences choice of operation. Overall survival rates and surgical outcomes are comparable, and surgical approach should be dictated by patient factors. 10/2/2019
Rohit Khisti, Yashwant Patidar, Lalit Garg, Amar Mukund, Sherin Sarah Thomas, Shiv K Sarin Correlation of baseline Portal pressure hepatic venous pressure gradient and Indocyanine Green Clearance Test With Post-transarterial Chemoembolization Acute Hepatic Failure CONCLUSION: Pretreatment evaluation of routine liver function is of fundamental importance before TACE. Baseline ICG retention test (ICG-R15) is a marker indicating the state of liver function in patients undergoing TACE and is an independent predictor for PTLF. Our study concludes that with a cutof... 9/14/2019
Jiao Wu, Jiangling Dong, Daniela Verzola, Keith Hruska, Giacomo Garibotto, Zhaoyong Hu, William E Mitch, Sandhya S Thomas Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk CONCLUSIONS: Our results show that SIRPα plays an important role as an anti-insulin mediator regulating pathways to cachexia. In muscle-specific SIRPα KO, changes in SIRPα serum levels seem to improve insulin signalling in muscle and WAT, suggesting crosstalk between muscle and adipose tissue. There... 9/12/2019
Malcolm H Squires, Cecilia G Ethun, Lorena P Suarez-Kelly, Peter Y Yu, Tasha M Hughes, Rita D Shelby, Thuy B Tran, George Poultsides, John Charlson, T Clark Gamblin, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley A Krasnick, Ryan C Fields, Raphael E Pollock, Valerie Grignol, Kenneth Cardona, J Harrison Howard Trends in the Use of Adjuvant Chemotherapy for High-Grade Truncal and Extremity Soft Tissue Sarcomas CONCLUSIONS: Rates of adjuvant chemotherapy for resected high-grade truncal or extremity STS have not decreased over time within the U.S. Sarcoma Collaborative, despite RCT data suggesting a lack of efficacy. In this retrospective multi-institutional analysis, adjuvant chemotherapy was not associate... 9/9/2019
Sarah Rhea, Rainer Hilscher, James I Rineer, Breda Munoz, Kasey Jones, Stacy M Endres-Dighe, Lauren M DiBiase, Emily E Sickbert-Bennett, David J Weber, Jennifer K MacFarquhar, Heather Dubendris, Georgiy Bobashev Creation of a Geospatially Explicit, Agent-based Model of a Regional Healthcare Network with Application to emClostridioides difficileem Infection Agent-based models (ABMs) describe and simulate complex systems comprising unique agents, or individuals, while accounting for geospatial and temporal variability among dynamic processes. ABMs are increasingly used to study healthcare-associated infections (ie, infections acquired during admission t... 8/22/2019
Olga Kantor, Jean Bao, Nora Jaskowiak, Katherine Yao, Jennifer Tseng The Prognostic Value of the AJCC 8th Edition Staging System for Patients Undergoing Neoadjuvant Chemotherapy for Breast Cancer CONCLUSIONS: Sixty-five percent of patients have a shift in clinical stage in the AJCC 8th edition. AJCC 8th edition staging has better predictive value for OS than 7th edition staging. While validation of these findings with an independent dataset is needed, 8th edition staging will help improve pr... 8/4/2019
Madhumita Premkumar, Devaraja Devurgowda, Tanmay Vyas, Saggere M Shasthry, Jelen S Khumuckham, Ritu Goyal, Sherin S Thomas, Guresh Kumar Left Ventricular Diastolic Dysfunction is Associated with Renal Dysfunction, Poor Survival and Low Health Related Quality of Life in Cirrhosis CONCLUSION: The grade of LVDD correlates with liver function, clinical events, risk of renal dysfunction and HRQoL. Evaluation of novel therapies which target symptomatic improvement in LVDD, should be done with suitable outcome measures, including HRQoL assessment. 7/31/2019
Mohammad Y Zaidi, Cecilia G Ethun, Thuy B Tran, George Poultsides, Valerie P Grignol, J Harrison Howard, Meena Bedi, Harveshp Mogal, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Brad Krasnick, Ryan C Fields, Shervin Oskouei, Nickolas Reimer, David Monson, Shishir K Maithel, Kenneth Cardona Assessing the Role of Neoadjuvant Chemotherapy in Primary High-Risk TruncalExtremity Soft Tissue Sarcomas An Analysis of the Multi-institutional US Sarcoma Collaborative CONCLUSION: For the patients with high-grade STS, NCT was associated with improved RFS and OS when tumors were 10 cm or larger and located in the extremity. However, no histiotype-specific advantage was identified. Future studies assessing the efficacy of NCT may consider focusing on these patients,... 7/26/2019
Timothy Feeney, Michael Cassidy, Yorghos Tripodis, David McAneny, Maureen Kavanah, Teviah Sachs, Jennifer F Tseng, Frederick Thurston Drake Correction to Association of Primary Language with Outcomes After Operations Typically Performed to Treat Cancer Analysis of a Statewide Database In the original article, there were errors in Table 1 that were not in accordance with requirements set by the Healthcare Cost and Utilization Project (HCUP) Data Use Agreement that apply to this article. Following is the corrected Table 1. 7/18/2019
Chris Erwin G Mercado, Saranath Lawpoolsri, Prayuth Sudathip, Jaranit Kaewkungwal, Amnat Khamsiriwatchara, Wirichada Pan-Ngum, Surapon Yimsamran, Siam Lawawirojwong, Kevin Ho, Nattwut Ekapirat, Rapeephan R Maude, Jacher Wiladphaingern, Verena I Carrara, Nicholas P J Day, Arjen M Dondorp, Richard J Maude Spatiotemporal epidemiology, environmental correlates, and demography of malaria in Tak Province, Thailand 2012-2015 CONCLUSIONS: There has been a large decline in reported clinical malaria from 2012 to 2015 in Tak Province. API was correlated with monthly climate and annual forest cover but these did not account for the trends over time. Ongoing elimination interventions on one or both sides of the border are mor... 7/18/2019
Madhumita Premkumar, Devaraja Rangegowda, Tanmay Vyas, Jelen S Khumuckham, Saggere M Shasthry, Sherin S Thomas, Ritu Goyal, Guresh Kumar, Shiv K Sarin Carvedilol Combined With Ivabradine Improves Left Ventricular Diastolic Dysfunction, Clinical Progression, and Survival in Cirrhosis CONCLUSIONS: Ivabradine combined with carvedilol improves LVDD, achieves THR more often and reduces risk of encephalopathy, acute kidney injury with improved survival in patients with cirrhosis. 7/16/2019
Patrick B Schwartz, Kara Vande Walle, Emily R Winslow, Cecilia G Ethun, Thuy B Tran, George Poultsides, Jennifer Tseng, Kevin Roggin, Valerie Grignol, John Harrison Howard, Bradley A Krasnick, Ryan C Fields, Harveshp Mogal, Callisia N Clarke, Rebecca Senehi, Konstantinos Votanopoulos, Kenneth Cardona, Daniel E Abbott Predictors of Disease-Free and Overall Survival in Retroperitoneal Sarcomas A Modern 16-Year Multi-Institutional Study from the United States Sarcoma Collaboration USSC CONCLUSIONS: The strongest predictors of disease-free and overall survival are tumor-specific characteristics, while surgical factors are less impactful. Nonsurgical therapies are not associated with improved outcomes despite persistent interest and utilization. Complete macroscopic resection (R0/R1... 7/9/2019
Mark Daniel G de Luna, Sergi Garcia-Segura, Chinee H Mercado, Yao-Tung Lin, Ming-Chun Lu Doping TiOsub2sub with CuSOsub4sub enhances visible light photocatalytic activity for organic pollutant degradation Photocatalysis is one of the most promising advanced oxidation processes due to the capability of solid catalyst to continuously produce oxidant species under light irradiation. The use of conventional UV lamps is high cost intensive, which undermines the possible implementation in developing countr... 7/6/2019
Konstantinos Chouliaras, Rebecca Senehi, Cecilia G Ethun, George Poultsides, Thuy Tran, Valerie Grignol, Thomas Clark Gamblin, Kevin K Roggin, Jennifer Tseng, Ryan C Fields, Sharon M Weber, Gregory B Russell, Edward A Levine, Kenneth Cardona, Konstantinos Votanopoulos Recurrence patterns after resection of retroperitoneal sarcomas An eight-institution study from the US Sarcoma Collaborative CONCLUSIONS: Recurrence after resection of RPS occurs in more than half of patients independently of resection status or perioperative chemotherapy and is equally distributed between locoregional and distant sites. Recurrence is primarily related to tumor biology and is associated with a significant... 6/28/2019
Nandini Venkateswaran, Carolina Mercado, Ann Q Tran, Armando Garcia, Pedro Francisco Monsalve Diaz, Sander R Dubovy, Anat Galor, Carol L Karp The use of high resolution anterior segment optical coherence tomography for the characterization of conjunctival lymphoma, conjunctival amyloidosis and benign reactive lymphoid hyperplasia CONCLUSIONS: Distinctive features on HR-OCT of conjunctival lymphoma, conjunctival amyloidosis and BRLH can help characterize these lesions beyond what is apparent with the clinical examination. Future studies can further validate this technology's use with more subtle and challenging lesions. 6/26/2019
Sharon H Saydah, Karen R Siegel, Giuseppina Imperatore, Carla Mercado, Edward W Gregg The Cardiometabolic Risk Profile of Young Adults With Diabetes in the US CONCLUSIONS: Young adults with diabetes have high rates of cardiometabolic risk factors, which can lead to an increased disease prevalence and mortality rate among these individuals as they age. 6/22/2019
Ji Young Bang, Charles Melbern Wilcox, Juan Pablo Arnoletti, Shyam Varadarajulu Superiority of endoscopic interventions over minimally invasive surgery for infected necrotizing pancreatitis meta-analysis of randomized trials CONCLUSIONS: An endoscopy-based treatment approach, as compared to minimally invasive surgery, significantly reduces complications in patients with infected necrotizing pancreatitis. 6/21/2019
Praveen Sridhar, Priya Misir, Hyunjee Kwak, Susanna Wl deGeus, Frederick T Drake, Michael R Cassidy, David A McAneny, Jennifer F Tseng, Teviah E Sachs Impact of Race, Insurance Status, and Primary Language on Presentation, Treatment, and Outcomes of Patients with Pancreatic Adenocarcinoma at a Safety-Net Hospital CONCLUSIONS: There were no statistically significant relationships between examined social determinants of health and use of operation or perioperative therapy. Patients treated at an urban safety-net hospital with a focus on vulnerable patient populations are able to provide outcomes similar to nat... 6/19/2019
Timothy Feeney, Michael Cassidy, Yorghos Tripodis, David McAneny, Maureen Kavanah, Teviah Sachs, Jennifer F Tseng, Frederick Thurston Drake Association of Primary Language with Outcomes After Operations Typically Performed to Treat Cancer Analysis of a Statewide Database CONCLUSIONS: No independent association was observed between primary language and outcomes after operations typically performed to treat cancer in the study population. The higher proportion of weekend admissions may suggest more acute or advanced presentations for non-English speakers. Long-term ou... 6/13/2019
Mohammad Y Zaidi, Cecilia G Ethun, Yuan Liu, George Poultsides, J Harrison Howard, Harveshp Mogal, Jennifer Tseng, Konstantinos Votanopoulos, Ryan C Fields, Kenneth Cardona The impact of unplanned excisions of truncalextremity soft tissue sarcomas A multi-institutional propensity score analysis from the US Sarcoma Collaborative CONCLUSIONS: UE of STS is not associated with worse prognosis compared to PE, though UE is associated with earlier locoregional recurrence in patients with high-grade tumors. Multimodality therapy is needed to achieve improved outcomes in these patients. 6/8/2019
Nicholas P Gannon, David M King, Cecilia G Ethun, John Charlson, Thuy B Tran, George Poultsides, Valerie Grignol, J Harrison Howard, Jennifer Tseng, Kevin K Roggin, Konstantinos Votanopoulos, Bradley Krasnick, Ryan C Fields, Kenneth Cardona, Meena Bedi The role of radiation therapy and margin width in localized soft-tissue sarcoma Analysis from the US Sarcoma Collaborative CONCLUSIONS: RT may play a larger role in minimizing LR than margin status. In patients with positive margins, RT may decrease LR to similar rates as a negative margin without RT and may be considered to decrease the risk of LR with anticipated close/positive margins. 6/8/2019
Carol L Karp, Carolina Mercado, Nandini Venkateswaran, Marco Ruggeri, Anat Galor, Armando Garcia, Kavitha R Sivaraman, Maria Paula Fernandez, Antonio Bermudez, Sander R Dubovy Use of High-Resolution Optical Coherence Tomography in the Surgical Management of Ocular Surface Squamous Neoplasia A Pilot Study CONCLUSIONS: HR-OCT has the potential to predict histologic tumor margins in OSSN. Optical identification of tumor margins could potentially decrease the incidence of residual positive margins and minimize healthy tissue removal. Advances in HR-OCT technology and integration into a microscope for "r... 6/5/2019
Puthiery Va, Kevin W Dodd, Lixia Zhao, Angela M Thompson-Paul, Carla I Mercado, Ana L Terry, Sandra L Jackson, Chia-Yih Wang, Catherine M Loria, Alanna J Moshfegh, Donna G Rhodes, Mary E Cogswell Evaluation of measurement error in 24-hour dietary recall for assessing sodium and potassium intake among US adults - National Health and Nutrition Examination Survey NHANES, 2014 CONCLUSIONS: Compared with 24HUE, using 24HDR underestimates mean sodium and potassium intake but is unbiased for the Na/K ratio. Additionally, using 24HDR as a measure of exposure in observational studies attenuates the true associations of sodium and potassium intake with health outcomes. 5/29/2019
Suma S Thomas, Hao Tang, Cornelia Bohne Noninnocent Role of Nasupsup Ions in the Binding of the N-Phenyl-2-naphthylammonium Cation as a Ditopic Guest with Cucurbit7uril Na^(+) ions influence the mechanism for the binding of the ditopic guest N-phenyl-2-naphthylammonium cation (Ph-AH^(+)-Np) to cucurbit[7]uril (CB[7]) by facilitating, at increased Na^(+) concentrations, the formation of a higher-order complex. Binding of the larger naphthyl moiety of Ph-AH^(+)-Np fo... 5/28/2019
Joe James, Marek J Slomka, Scott M Reid, Saumya S Thomas, Sahar Mahmood, Alexander M P Byrne, Jayne Cooper, Christine Russell, Benjamin C Mollett, Eric Agyeman-Dua, Steve Essen, Ian H Brown, Sharon M Brookes Proceedings Paper-Avian Diseases 10th AI Symposium Issue Development and Application of Real-Time PCR Assays for Specific Detection of Contemporary Avian Influenza Virus Subtypes N5, N6, N7, N8, and N9 Previously published NA subtype-specific real-time reverse-transcriptase PCRs (RRT-PCRs) were further validated for the detection of five avian influenza virus (AIV) NA subtypes, namely N5, N6, N7, N8, and N9. Testing of 30 AIV isolates of all nine NA subtypes informed the assay assessments, with th... 5/28/2019
Scott M Reid, Alejandro Núñez, Amanda H Seekings, Saumya S Thomas, Marek J Slomka, Sahar Mahmood, Jane R Clark, Jill Banks, Sharon M Brookes, Ian H Brown Two Single Incursions of H7N7 and H5N1 Low Pathogenicity Avian Influenza in UK Broiler Breeders During 2015 and 2016 Low pathogenicity (LP) avian influenza viruses (AIVs) have a natural reservoir in wild birds. These cause few (if any) overt clinical signs, but include H5 and H7 LPAIVs, which are notifiable in poultry. In the European Union, notifiable avian disease (NAD) demands laboratory confirmation with promp... 5/28/2019
Marek J Slomka, Anita Puranik, Sahar Mahmood, Saumya S Thomas, Amanda H Seekings, Alexander M P Byrne, Alejandro Núñez, Carlo Bianco, Benjamin C Mollett, Samantha Watson, Ian H Brown, Sharon M Brookes Ducks Are Susceptible to Infection with a Range of Doses of H5N8 Highly Pathogenic Avian Influenza Virus 2016, Clade 2344b and Are Largely Resistant to Virus-Specific Mortality, but Efficiently Transmit Infection to Contact Turkeys Widespread H5N8 highly pathogenic avian influenza virus (HPAIV; clade 2.3.4.4b) infections occurred in wild birds and poultry across Europe during winter 2016-17. Four different doses of H5N8 HPAIV (A/wigeon/Wales/052833/2016 [wg-Wal-16]) were used to infect 23 Pekin ducks divided into four separate... 5/28/2019
Chengyi Zheng, Wei Yu, Fagen Xie, Wansu Chen, Cheryl Mercado, Lina S Sy, Lei Qian, Sungching Glenn, Gina Lee, Hung Fu Tseng, Jonathan Duffy, Lisa A Jackson, Matthew F Daley, Brad Crane, Huong Q McLean, Steven J Jacobsen The use of natural language processing to identify Tdap-related local reactions at five health care systems in the Vaccine Safety Datalink CONCLUSION: The NLP algorithm achieved high accuracy, and demonstrated the potential of NLP to reduce the efforts of manual chart review in vaccine safety studies. 5/27/2019
Bhavana V Chapman, Cameron W Swanick, Matthew S Ning, Pamela K Allen, Pamela T Soliman, Shannon N Westin, Vishakha Pardeshi, Russell R Broaddus, Karen H Lu, Anuja Jhingran, Patricia J Eifel, Ann H Klopp Adjuvant combined-modality therapy for stage IIIC endometrioid and non-endometrioid endometrial cancer CONCLUSIONS: Combined-modality therapy including adjuvant external beam pelvic radiotherapy yields excellent outcomes for patients with all subtypes of node-positive endometrial cancer. The most pronounced DSS advantage from adjuvant chemoradiotherapy was evident in women with non-endometrioid endom... 5/22/2019
Rulin C Hechter, Lei Qian, Sara Y Tartof, Lina S Sy, Nicola P Klein, Eric Weintraub, Cheryl Mercado, Allison Naleway, Huong Q McLean, Steven J Jacobsen Vaccine safety in HIV-infected adults within the Vaccine Safety Datalink Project CONCLUSIONS: Routinely administered vaccines are generally safe for HIV-infected adults. 5/9/2019
Matthew R Egyud, Jennifer F Tseng, Kei Suzuki Multidisciplinary Therapy of Esophageal Cancer Multimodality therapy is the standard of care for locoregional esophageal cancers (greater than clinical T3 or Nþ), including Siewert type 1 and 2 gastroesophageal junction tumors. Induction regimen, chemotherapy only or chemoradiation, is an area of controversy and often institution-specific, as ne... 5/4/2019
J Nateqi, S Lin, H Krobath, S Gruarin, T Lutz, T Dvorak, A Gruschina, R Ortner From symptom to diagnosis-symptom checkers re-evaluated Are symptom checkers finally sufficient and accurate to use An update from the ENT perspective CONCLUSIONS: Symptoma is the first and only viable solution in this market. Large-scale studies should be conducted to further validate these results as well as to assess the actual practical performance of the symptom checkers and their ability to diagnose rare diseases. 4/18/2019
Ayelén Moreno-Irusta, Jackelyn M Kembro, Esteban M Domínguez, Arturo Matamoros-Volante, Maria N Gallea, Rosa Molina, Hector A Guidobaldi, Claudia L Treviño, Maria J Figueras, Ana Babini, Nelso A Paina, Carlos A N Mercado, Laura C Giojalas Sperm physiology varies according to ultradian and infradian rhythms The spermatozoon must be physiologically prepared to fertilize the egg, process called capacitation. Human sperm samples are heterogeneous in their ability to capacitate themselves, which leads to variability between samples from the same or different donors, and even along the seasons. Here we stud... 4/14/2019
Sjors Klompmaker, Walderik J van der Vliet, Stijn J Thoolen, Ana Sofia Ore, Koen Verkoulen, Monica Solis-Velasco, Elena G Canacari, Jonathan B Kruskal, Khalid O Khwaja, Jennifer F Tseng, Mark P Callery, Tara S Kent, A James Moser Procedure-specific Training for Robot-assisted Distal Pancreatectomy CONCLUSION: Supervised procedure-specific training enabled successful implementation of RADP by practicing surgeons with immediate improvements in length of stay, without adverse effects on safety. 4/5/2019
Meghan Sri Karuturi, Xiudong Lei, Yu Shen, Sharon H Giordano, Cameron W Swanick, Benjamin D Smith Long-term decision regret surrounding systemic therapy in older breast cancer survivors A population-based survey study INTRODUCTION: Little is known regarding regret experienced by older breast cancer survivors surrounding the choice for adjuvant systemic therapy, which limits providers' ability to optimally engage in the shared decision-making process. To address this, we evaluated endocrine therapy and chemotherap... 4/4/2019
Karen M Byrne, Chloe Marie C Mercado, Thaddeus N Nnabue, Traci D Paige, Willy A Flegel Inhibition of blood group antibodies by soluble substances The presence of multiple alloantibodies or an antibody to a highprevalance antigen in a patient sample can pose challenges in antibody identification. The pattern of reactivity seen on an antibody panel may show various strengths of reactivity by different methods of testing or same strength of reac... 3/26/2019
Adam L Holtzman, Ronny L Rotondo, Michael S Rutenberg, Daniel J Indelicato, Catherine E Mercado, Dinesh Rao, Daryoush Tavanaiepour, Christopher G Morris, Debbie Louis, Stella Flampouri, William M Mendenhall Proton therapy for skull-base chondrosarcoma, a single-institution outcomes study CONCLUSION: High-dose, double-scattered 3D conformal proton therapy alone or following surgical resection for skull-base chondrosarcoma is an effective treatment with a high rate of local control with no acute grade 3 radiation-related toxicity. Further follow-up of this cohort is necessary to bette... 3/4/2019
Joseph Reza, Alvin Jo Almodovar, Milan Srivastava, Paula P Veldhuis, Swati Patel, Na'im Fanaian, Xiang Zhu, Sally A Litherland, J Pablo Arnoletti emK-RASem Mutant Gene Found in Pancreatic Juice Activated Chromatin From Peri-ampullary Adenocarcinomas External pancreatic duct stents inserted after resection of pancreatic head tumors provide unique access to pancreatic juice analysis of genetic and metabolic components that may be associated with peri-ampullary tumor progression. For this pilot study, portal venous blood and pancreatic juice sampl... 3/1/2019
Catherine E Mercado, William F Hartsell, Charles B Simone, Henry K Tsai, Carlos E Vargas, He J Zhu, Randal H Henderson, Jing Zeng, Gary L Larson, Bradford S Hoppe Proton therapy for thymic malignancies multi-institutional patterns-of-care and early clinical outcomes from the proton collaborative group and the university of Florida prospective registries Objective: Thymic malignancies (TM) are rare tumors with long-term survivorship, causing concerns for radiotherapy-related late side effects. Proton therapy (PT) reduces the radiation dose to organs at risk, potentially decreasing long-term toxicities while preserving disease control. We report patt... 2/21/2019
Nosayaba Osazuwa-Peters, Kara M Christopher, Lauren M Cass, Sean T Massa, Adnan S Hussaini, Anit Behera, Ronald J Walker, Mark A Varvares Whats Love Got to do with it Marital status and survival of head and neck cancer CONCLUSIONS: Being married confers survival advantage for HNC survivors. Our finding underscores the need to recognise this aspect of survivorship. Social support should be considered part of standard care for managing HNC. There may also be need to develop other support mechanisms, especially for u... 2/21/2019
Daniel Castillo, Juan Manuel Galvez, Luis J Herrera, Fernando Rojas, Olga Valenzuela, Octavio Caba, Jose Prados, Ignacio Rojas Leukemia multiclass assessment and classification from Microarray and RNA-seq technologies integration at gene expression level In more recent years, a significant increase in the number of available biological experiments has taken place due to the widespread use of massive sequencing data. Furthermore, the continuous developments in the machine learning and in the high performance computing areas, are allowing a faster and... 2/13/2019
Pragati G Advani, Xiudong Lei, Cameron W Swanick, Ying Xu, Yu Shen, Nathan A Goodwin, Grace L Smith, Sharon H Giordano, Kelly K Hunt, Reshma Jagsi, Benjamin D Smith Local Therapy Decisional Regret in Older Women With Breast Cancer A Population-Based Study CONCLUSIONS: Local therapy regret afflicts nearly one quarter of our cohort of older breast cancer survivors, and it is associated with black race, less education, and more extensive nodal dissection, but not breast surgery. Regret is distinct from health utility, suggesting that it is a unique psyc... 2/5/2019
Nosayaba Osazuwa-Peters, Eric Adjei Boakye, Rebecca L Rohde, Rajan N Ganesh, Ammar S Moiyadi, Adnan S Hussaini, Mark A Varvares Understanding of risk factors for the human papillomavirus HPV infection based on gender and race This study assessed if race and gender predict known sexual risk factors associated with HPV. Data (n = 301) were from a cross-sectional study conducted at a drag racing event on September 12-13, 2015 in Madison, Illinois. Both multivariable logistic and linear regression models estimated the associ... 1/24/2019
Ashwani Gore, Michael J Hoch, Hui-Kuo G Shu, Jeffrey J Olson, Alfredo D Voloschin, Brent D Weinberg Institutional Implementation of a Structured Reporting System Our Experience with the Brain Tumor Reporting and Data System CONCLUSION: Implementing a structured template for brain tumor imaging improves perception of radiology reports among radiologists and referring providers involved in the care of brain tumor patients. 1/22/2019
John D Mayfield, Catherine E Mercado, Frederic J Kaye, William M Mendenhall Cetuximab-associated pulmonary toxicity in concurrent chemoradiation for the treatment of a squamous cell carcinoma of the head and neck CONCLUSION: Although severe pulmonary toxicity caused by EGFR inhibitors has been well described in the literature, ILD caused by cetuximab, an EGFR monoclonal antibody, is rare and not well-documented. Given its life-threatening effects, awareness of this potential side effect and early diagnosis i... 1/8/2019
Ammara A Watkins, Manuel Castillo-Angeles, Rodrigo Calvillo-Ortiz, Camila R Guetter, Mariam F Eskander, Eiman Ghaffarpasand, Luis Anguiano-Landa, Jennifer F Tseng, Arthur J Moser, Mark P Callery, Tara S Kent Braden scale for pressure ulcer risk predicts rehabilitation placement after pancreatic resection CONCLUSION: A marker of frailty routinely collected daily by nursing staff, the Braden scale, is available to help surgeons predict the need for postoperative rehabilitation placement after pancreatic resection. Engaging discharge planning services for at-risk patients may help prevent delayed hospi... 1/5/2019
Anne Edvardsen, Inga Jarosch, Anita Grongstad, Laura Wiegand, Rainer Gloeckl, Klaus Kenn, Martijn A Spruit A randomized cross-over trial on the direct effects of oxygen supplementation therapy using different devices on cycle endurance in hypoxemic patients with Interstitial Lung Disease CONCLUSIONS: Supplemental oxygen provided by the Oxymizer significantly, but modestly, improved cycle endurance time and SpO2 at isotime in ILD patients compared to CNC. 12/29/2018
Nicole Scherr, Raphael Bieri, Sangeeta S Thomas, Aurélie Chauffour, Nitin Pal Kalia, Paul Schneide, Marie-Thérèse Ruf, Araceli Lamelas, Malathy S S Manimekalai, Gerhard Grüber, Norihisa Ishii, Koichi Suzuki, Marcel Tanner, Garrett C Moraski, Marvin J Miller, Matthias Witschel, Vincent Jarlier, Gerd Pluschke, Kevin Pethe Targeting the Mycobacterium ulcerans cytochrome bcsub1subaasub3sub for the treatment of Buruli ulcer Mycobacterium ulcerans is the causative agent of Buruli ulcer, a neglected tropical skin disease that is most commonly found in children from West and Central Africa. Despite the severity of the infection, therapeutic options are limited to antibiotics with severe side effects. Here, we show that M.... 12/19/2018
Catherine E Mercado, Adam L Holtzman, Ronny Rotondo, Michael S Rutenberg, William M Mendenhall Proton therapy for skull base tumors A review of clinical outcomes for chordomas and chondrosarcomas CONCLUSION: Proton therapy is a modern RT technique that has demonstrated improved preliminary clinical outcomes in the treatment of skull base chordomas and chondrosarcomas compared to conventional radiotherapy, and comparable to other advanced photon-based RT techniques. 12/12/2018
Carla I Mercado, Mary E Cogswell, Catherine M Loria, Kiang Liu, Norrina Allen, Cathleen Gillespie, Chia-Yih Wang, Ian H de Boer, Jacqueline Wright Validity of predictive equations for 24-h urinary potassium excretion based on timing of spot urine collection among adults the MESA and CARDIA Urinary Sodium Study and NHANES Urinary Sodium Calibration Study CONCLUSION: Because predicted 24-h uK accuracy varies by timing of spot urine collection, published prediction equations, and within age-race-sex subgroups, study results making use of predicted 24-h uK in association with health outcomes should be interpreted with caution. It is possible that a mor... 12/12/2018
María M Pérez, Luis Javier Herrera, Francisco Carrillo, Oscar E Pecho, Diana Dudea, Cristina Gasparik, Razvan Ghinea, Alvaro Della Bona Whiteness difference thresholds in dentistry OBJECTIVE: To determine the visual whiteness thresholds for esthetic dentistry using the whiteness index for dentistry based on CIELAB color space (WI(D)). 12/12/2018
Jeroen R Huyghe, Stephanie A Bien, Tabitha A Harrison, Hyun Min Kang, Sai Chen, Stephanie L Schmit, David V Conti, Conghui Qu, Jihyoun Jeon, Christopher K Edlund, Peyton Greenside, Michael Wainberg, Fredrick R Schumacher, Joshua D Smith, David M Levine, Sarah C Nelson, Nasa A Sinnott-Armstrong, Demetrius Albanes, M Henar Alonso, Kristin Anderson, Coral Arnau-Collell, Volker Arndt, Christina Bamia, Barbara L Banbury, John A Baron, Sonja I Berndt, Stéphane Bézieau, D Timothy Bishop, Juergen Boehm, Heiner Boeing, Hermann Brenner, Stefanie Brezina, Stephan Buch, Daniel D Buchanan, Andrea Burnett-Hartman, Katja Butterbach, Bette J Caan, Peter T Campbell, Christopher S Carlson, Sergi Castellví-Bel, Andrew T Chan, Jenny Chang-Claude, Stephen J Chanock, Maria-Dolores Chirlaque, Sang Hee Cho, Charles M Connolly, Amanda J Cross, Katarina Cuk, Keith R Curtis, Albert de la Chapelle, Kimberly F Doheny, David Duggan, Douglas F Easton, Sjoerd G Elias, Faye Elliott, Dallas R English, Edith J M Feskens, Jane C Figueiredo, Rocky Fischer, Liesel M FitzGerald, David Forman, Manish Gala, Steven Gallinger, W James Gauderman, Graham G Giles, Elizabeth Gillanders, Jian Gong, Phyllis J Goodman, William M Grady, John S Grove, Andrea Gsur, Marc J Gunter, Robert W Haile, Jochen Hampe, Heather Hampel, Sophia Harlid, Richard B Hayes, Philipp Hofer, Michael Hoffmeister, John L Hopper, Wan-Ling Hsu, Wen-Yi Huang, Thomas J Hudson, David J Hunter, Gemma Ibañez-Sanz, Gregory E Idos, Roxann Ingersoll, Rebecca D Jackson, Eric J Jacobs, Mark A Jenkins, Amit D Joshi, Corinne E Joshu, Temitope O Keku, Timothy J Key, Hyeong Rok Kim, Emiko Kobayashi, Laurence N Kolonel, Charles Kooperberg, Tilman Kühn, Sébastien Küry, Sun-Seog Kweon, Susanna C Larsson, Cecelia A Laurie, Loic Le Marchand, Suzanne M Leal, Soo Chin Lee, Flavio Lejbkowicz, Mathieu Lemire, Christopher I Li, Li Li, Wolfgang Lieb, Yi Lin, Annika Lindblom, Noralane M Lindor, Hua Ling, Tin L Louie, Satu Männistö, Sanford D Markowitz, Vicente Martín, Giovanna Masala, Caroline E McNeil, Marilena Melas, Roger L Milne, Lorena Moreno, Neil Murphy, Robin Myte, Alessio Naccarati, Polly A Newcomb, Kenneth Offit, Shuji Ogino, N Charlotte Onland-Moret, Barbara Pardini, Patrick S Parfrey, Rachel Pearlman, Vittorio Perduca, Paul D P Pharoah, Mila Pinchev, Elizabeth A Platz, Ross L Prentice, Elizabeth Pugh, Leon Raskin, Gad Rennert, Hedy S Rennert, Elio Riboli, Miguel Rodríguez-Barranco, Jane Romm, Lori C Sakoda, Clemens Schafmayer, Robert E Schoen, Daniela Seminara, Mitul Shah, Tameka Shelford, Min-Ho Shin, Katerina Shulman, Sabina Sieri, Martha L Slattery, Melissa C Southey, Zsofia K Stadler, Christa Stegmaier, Yu-Ru Su, Catherine M Tangen, Stephen N Thibodeau, Duncan C Thomas, Sushma S Thomas, Amanda E Toland, Antonia Trichopoulou, Cornelia M Ulrich, David J Van Den Berg, Franzel J B van Duijnhoven, Bethany Van Guelpen, Henk van Kranen, Joseph Vijai, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Korbinian Weigl, Stephanie J Weinstein, Emily White, Aung Ko Win, C Roland Wolf, Alicja Wolk, Michael O Woods, Anna H Wu, Syed H Zaidi, Brent W Zanke, Qing Zhang, Wei Zheng, Peter C Scacheri, John D Potter, Michael C Bassik, Anshul Kundaje, Graham Casey, Victor Moreno, Goncalo R Abecasis, Deborah A Nickerson, Stephen B Gruber, Li Hsu, Ulrike Peters Discovery of common and rare genetic risk variants for colorectal cancer To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in ... 12/5/2018
Katheryn Hope Wilkinson, Cecilia G Ethun, Matthew Hembrook, Meena Bedi, John Charlson, Harveshp Mogal, Susan Tsai, Kathleen Christians, Thuy B Tran, George Poultsides, Valerie Grignol, John Harrison Howard, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Darren Cullinan, Ryan C Fields, Sharon Weber, Thomas Clark Gamblin, Kenneth Cardona, Callisia N Clarke Outcomes of Elderly Patients Undergoing Curative Resection for Retroperitoneal Sarcomas Analysis From the US Sarcoma Collaborative CONCLUSIONS: Advanced age was not associated with an increased risk of perioperative morbidity and mortality following resection of RPS in this multi-institutional review. Although short-term oncologic outcomes were similar in both groups, the risk of death after sarcoma recurrence was higher in eld... 12/4/2018
Munizay Paracha, Kathryn Van Orden, Gregory Patts, Jennifer Tseng, David McAneny, Teviah Sachs Opportunity Lost Diagnostic Laparoscopy in Patients with Pancreatic Cancer in the National Surgical Quality Improvement Program Database BACKGROUND: Routine preoperative staging in pancreas cancer is controversial. We sought to evaluate the rates of diagnostic laparoscopy (DLAP) for pancreatic cancer. 11/28/2018
Nandini Venkateswaran, Carolina Mercado, Anat Galor, Carol L Karp Comparison of Topical 5-Fluorouracil and Interferon Alfa-2b as Primary Treatment Modalities for Ocular Surface Squamous Neoplasia CONCLUSIONS: This is the first direct comparison study between 5FU and IFN eye drops as primary treatment modalities for OSSN. Both modalities resulted in a high frequency of tumor resolution and low recurrence rates and are effective treatment options for OSSN. 11/25/2018
Ji Young Bang, Juan Pablo Arnoletti, Bronte A Holt, Bryce Sutton, Muhammad K Hasan, Udayakumar Navaneethan, Nicholas Feranec, C Mel Wilcox, Benjamin Tharian, Robert H Hawes, Shyam Varadarajulu An Endoscopic Transluminal Approach, Compared With Minimally Invasive Surgery, Reduces Complications and Costs for Patients With Necrotizing Pancreatitis CONCLUSIONS: In a randomized trial of 66 patients, an endoscopic transluminal approach for infected necrotizing pancreatitis, compared with minimally invasive surgery, significantly reduced major complications, lowered costs, and increased quality of life. Clinicaltrials.gov no: NCT02084537. 11/20/2018
Neige Journy, Daniel J Indelicato, Diana R Withrow, Tetsuo Akimoto, Claire Alapetite, Masayuki Araya, Andrew Chang, John Han-Chih Chang, Brian Chon, Michael E Confer, Yusuke Demizu, Rémi Dendale, Jérôme Doyen, Ralph Ermoian, Kristin Gurtner, Christine Hill-Kayser, Hiromitsu Iwata, Joo-Young Kim, Young Kwok, Nadia N Laack, Choonsik Lee, Do Hoon Lim, Lilia Loredo, Victor S Mangona, David B Mansur, Masao Murakami, Shigeyuki Murayama, Takashi Ogino, Barbora Ondrová, Rahul R Parikh, Arnold C Paulino, Stephanie Perkins, Naren R Ramakrishna, Ronald Richter, Barbara Rombi, Satoshi Shibata, Shinichi Shimizu, Beate Timmermann, Tamara Vern-Gross, Chiachien J Wang, Damien C Weber, John Ben Wilkinson, Petra Witt Nyström, Torunn I Yock, Ruth A Kleinerman, Amy Berrington de Gonzalez Patterns of proton therapy use in pediatric cancer management in 2016 An international survey CONCLUSION: To our knowledge, this survey provides the first worldwide assessment of proton therapy use for pediatric cancer management. Since previous estimates in the United States and Europe, CNS tumors remain the cancer types most commonly treated with protons in 2016. However, the proportion of... 11/12/2018
Debra L Richardson, Shelly M Seward, Kathleen N Moore Antibody Drug Conjugates in the Treatment of Epithelial Ovarian Cancer Antibody drug conjugates are novel mechanisms for delivering chemotherapy. They vary based on the targeted antigen, conjugated cytotoxic, and the type of linker used. These differences determine what cells are targeted. There are 2 antibody drug conjugates approved for use in cancer. For epithelial ... 11/5/2018
Simona F Shaitelman, Xiudong Lei, Alastair Thompson, Pamela Schlembach, Elizabeth S Bloom, Isidora Y Arzu, Daniel Buchholz, Gregory Chronowski, Tomas Dvorak, Emily Grade, Karen Hoffman, George Perkins, Valerie K Reed, Shalin J Shah, Michael C Stauder, Eric A Strom, Welela Tereffe, Wendy A Woodward, Diana N Amaya, Yu Shen, Gabriel N Hortobagyi, Kelly K Hunt, Thomas A Buchholz, Benjamin D Smith Three-Year Outcomes With Hypofractionated Versus Conventionally Fractionated Whole-Breast Irradiation Results of a Randomized, Noninferiority Clinical Trial CONCLUSION: Three years after WBI followed by a tumor bed boost, outcomes with hypofractionation and conventional fractionation are similar. Tumor bed boost, chemotherapy, and larger breast size do not seem to be strong contraindications to HF-WBI. 11/1/2018
Stijn van Roessel, Gyulnara G Kasumova, Joanne Verheij, Robert M Najarian, Laura Maggino, Matteo de Pastena, Giuseppe Malleo, Giovanni Marchegiani, Roberto Salvia, Sing Chau Ng, Susanna W de Geus, Sanne Lof, Francesco Giovinazzo, Jacob L van Dam, Tara S Kent, Olivier R Busch, Casper H van Eijck, Bas Groot Koerkamp, Mohammed Abu Hilal, Claudio Bassi, Jennifer F Tseng, Marc G Besselink International Validation of the Eighth Edition of the American Joint Committee on Cancer AJCC TNM Staging System in Patients With Resected Pancreatic Cancer CONCLUSIONS AND RELEVANCE: The eighth edition of the TNM staging system demonstrated a more equal distribution among stages and a modestly increased prognostic accuracy in patients with resected pancreatic ductal adenocarcinoma compared with the seventh edition. The revised T stage remains poorly as... 10/5/2018
Peter Y Yu, Eliza W Beal, Tasha M Hughes, Lorena P Suarez-Kelly, Rita D Shelby, Cecilia G Ethun, Thuy B Tran, George Poultsides, John Charlson, T Clark Gamblin, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Bradley A Krasnick, Ryan C Fields, Raphael E Pollock, Valerie Grignol, Kenneth Cardona, J Harrison Howard Perioperative chemotherapy is not associated with improved survival in high-grade truncal sarcoma CONCLUSIONS: In this multi-institutional retrospective analysis of resected high-grade truncal STS, receipt of perioperative CTX was not associated with improved OS, which may be related to selection bias. Microscopically negative margin status was the only independent factor associated with OS. 10/4/2018
Scott M Reid, Sharon M Brookes, Alejandro Núñez, Jill Banks, C Daniel Parker, Vanessa Ceeraz, Christine Russell, Amanda Seekings, Saumya S Thomas, Anita Puranik, Ian H Brown Detection of non-notifiable H4N6 avian influenza virus in poultry in Great Britain A 12-month pilot project for notifiable avian disease (NAD) exclusion testing in chicken and turkey flocks in Great Britain (GB) offered, in partnership with industry, opportunities to carry out differential diagnosis in flocks where NAD was not suspected, and to identify undetected or undiagnosed i... 10/2/2018
Aileen C Johnson, Cecilia G Ethun, Yuan Liu, George Poultsides, John H Howard, Meena Bedi, John Charlson, Jennifer Tseng, Kevin K Roggin, Konstantinos Votanopoulos, Darren Cullinan, Ryan C Fields, Shishir K Maithel, Kenneth Cardona, and other members of the US Sarcoma Collaborative A novel, simplified, externally validated staging system for truncalextremity soft tissue sarcomas An analysis of the US Sarcoma Collaborative database CONCLUSIONS: Our proposed staging system maintains prognostic significance between stages within a simplified system. For high-grade tumors, a cutoff of 7.5 cm, instead of 5 cm, maintains discrimination for survival and could be a more clinically applicable cutoff for future clinical trials. 9/28/2018
Ting-Gang Li, Dan-Dan Zhang, Lei Zhou, Zhi-Qiang Kong, Adamu S Hussaini, Dan Wang, Jun-Jiao Li, Dylan P G Short, Nikhilesh Dhar, Steven J Klosterman, Bao-Li Wang, Chun-Mei Yin, Krishna V Subbarao, Jie-Yin Chen, Xiao-Feng Dai Genome-Wide Identification and Functional Analyses of the CRK Gene Family in Cotton Reveals emGbCRK18em Confers Verticillium Wilt Resistance in emGossypium barbadenseem Cysteine-rich receptor-like kinases (CRKs) are a large subfamily of plant receptor-like kinases that play a critical role in disease resistance in plants. However, knowledge about the CRK gene family in cotton and its function against Verticillium wilt (VW), a destructive disease caused by Verticill... 9/27/2018
Carmel L Mercado, Brandon H Pham, Shannon Beres, Michael F Marmor, Scott R Lambert Unilateral retinitis pigmentosa in children CONCLUSIONS: Childhood-onset "unilateral RP" remains a difficult and uncertain diagnosis. ERG testing and longitudinal and widefield fundus examination are necessary to exclude asymmetrical disease. Although unilateral degeneration may exist in some children, its inherited or acquired etiology remai... 9/24/2018
Carolina L Mercado, Cameron Pole, James Wong, Juan F Batlle, Fabiola Roque, Noah Shaikh, Juan C Murillo, Anat Galor, Carol L Karp Surgical versus medical treatment for ocular surface squamous neoplasia A quality of life comparison CONCLUSION: Quality of life considerations before, during, and after OSSN treatment is an important yet understudied topic. Our study is the first to look at QoL parameters in OSSN treatment and we found that patients in both medically and surgically treated groups had similar QoL metric but were dr... 9/16/2018
Kathleen Smith, Elnaz Karimian Azari, Traci E LaMoia, Tania Hussain, Veronika Vargova, Katalin Karolyi, Paula P Veldhuis, Juan Pablo Arnoletti, Sebastian G de la Fuente, Richard E Pratley, Timothy F Osborne, George A Kyriazis T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways CONCLUSIONS: Our studies demonstrate that STRs have evolved to modulate glucose absorption via the regulation of its transport and to prevent the development of exacerbated hyperglycemia due to the ingestion of high levels of sugars. 9/12/2018
Krista Hachey, Ryan Morgan, Amy Rosen, Sowmya R Rao, David McAneny, Jennifer Tseng, Gerard Doherty, Teviah Sachs Quality Comes with the Anatomic Territory Evaluating the Impact of Surgeon Operative Mix on Patient Outcomes After Pancreaticoduodenectomy CONCLUSIONS: Surgeon PD volume is an important predictor of outcomes after PD. However, surgeon OM volume identifies a subset of lower-PD-volume surgeons with more favorable outcomes. 9/7/2018
Jennifer R Rineer, Sarah Duhart Clarke, Laurie A Cluff, Nicholas C Peiper Comparing medical and recreational cannabis use among employees associations with health and work-related outcomes Nearly one in five US employees reports having used cannabis in the past year. As policies and laws regarding cannabis use rapidly change, concerns have arisen over employees' use of cannabis, for both medical and recreational purposes. While extant workplace research has not distinguished between t... 9/5/2018
Jeffrey J Siracuse, Munizay Paracha, Alik Farber, Denis Rybin, Gheorghe Doros, Jennifer Tseng, David McAneny, Teviah Sachs Never events after hepatopancreatobiliary operations BACKGROUND: In 2008, the Centers for Medicare & Medicaid Services (CMS) terminated reimbursement for never events (NE). NE in hepatopancreatobiliary (HPB) patients are poorly understood. We investigated the incidence and effects of NE in this population. 8/28/2018
Shane R Stecklein, Simona F Shaitelman, Gildy V Babiera, Isabelle Bedrosian, Dalliah M Black, Matthew T Ballo, Isadora Arzu, Eric A Strom, Valerie K Reed, Tomas Dvorak, Benjamin D Smith, Wendy A Woodward, Karen E Hoffman, Pamela J Schlembach, Steve M Kirsner, Christopher L Nelson, Jinzhong Yang, William Guerra, Shiva Dibaj, Elizabeth S Bloom Prospective Comparison of Toxicity and Cosmetic Outcome After Accelerated Partial Breast Irradiation With Conformal External Beam Radiotherapy or Single-Entry Multilumen Intracavitary Brachytherapy CONCLUSIONS: Brachytherapy APBI is associated with higher rates of grade 1 fibrosis and seroma than 3-dimensional CRT but lower rates of grade 1 edema and grade 2 to 3 pain than 3-dimensional CRT. Rates of radiation oncologist-reported fair or poor cosmetic outcomes are higher with brachytherapy. We... 8/21/2018
Anushree Das, Suma S Thomas, August A Garofoli, Kevin A Chavez, Jeanette A Krause, Cornelia Bohne, Anna D Gudmundsdottir Steric Demand and Rate-determining Step for Photoenolization of Di-ortho-substituted Acetophenone Derivatives Laser flash photolysis of ketone 1 in argon-saturated methanol yields triplet biradical 1BR (τ = 63 ns) that intersystem crosses to form photoenols Z-1P (λ(max) = 350 nm, τ ~ 10 μs) and E-1P (λ(max) = 350 nm, τ > 6 ms). The activation barrier for Z-1P re-forming ketone 1 through a 1,5-H shift was de... 8/14/2018
Ryan Morgan, Michael Cassidy, Susanna W L DeGeus, Jennifer Tseng, David McAneny, Teviah Sachs Presentation and Survival of Gastric Cancer Patients at an Urban Academic Safety-Net Hospital CONCLUSION: Hispanic ethnicity, Central American birthplace, Medicaid insurance, and increased neighborhood poverty were associated with late-stage presentation of gastric cancer with poor outcomes. Further study of these populations may lead to screening protocols in order to increase earlier detec... 8/12/2018
Munizay Paracha, Ariel E Hirsch, Jennifer F Tseng, David B McAneny, Teviah E Sachs Scholarly impact of student authorship on surgical research CONCLUSIONS: The number of SA in JACS publications is increasing, without detriment to CA scholarly advancement. Involving students in surgical research should be encouraged. 8/9/2018
Shalom Sara Thomas, Mina Kim, Seung Je Lee, Youn-Soo Cha Antiobesity Effects of Purple Perilla Perilla frutescens var acuta on Adipocyte Differentiation and Mice Fed a High-fat Diet Purple perilla (PE) is a medicinal plant that has several health benefits. In this study, the antiobesity effect of PE was studied in 3T3-L1 preadipocytes and C57BL/6J mice fed high-fat diets. Triglyceride quantification and Oil Red O staining in matured adipocytes revealed that PE reduced lipid acc... 8/3/2018
J Pablo Arnoletti, Na'im Fanaian, Joseph Reza, Ryan Sause, Alvin Jo Almodovar, Milan Srivastava, Swati Patel, Paula P Veldhuis, Elizabeth Griffith, Yai-Ping Shao, Xiang Zhu, Sally A Litherland Pancreatic and bile duct cancer circulating tumor cells CTC form immune-resistant multi-cell type clusters in the portal venous circulation Circulating tumor cells (CTC) enter the blood from many carcinomas and represent a likely source of metastatic dissemination. In contrast to the peripheral circulation, KRAS mutation- positive CTC thrive in the portal venous blood of patients with pancreatic ductal adenocarcinoma (PDAC). To analyze ... 8/2/2018
Kevin J O'Brien, Wendy J Introne, Orhan Akal, Tulay Akal, Adrian Barbu, Melissa P McGowan, Melissa A Merideth, Samuel L Seward, William A Gahl, Bernadette R Gochuico Prolonged treatment with open-label pirfenidone in Hermansky-Pudlak syndrome pulmonary fibrosis CONCLUSIONS: Chronic treatment with pirfenidone may provide clinical benefit with few adverse effects for some patients with HPS pulmonary fibrosis. These results suggest that compassionate use of pirfenidone could be considered on a case-by-case basis for patients with HPS pulmonary fibrosis. 7/30/2018
Meriem Mokhtech, Catherine E Mercado, James W Lynch, Nancy P Mendenhall, William M Mendenhall Radiotherapy for extranodal classic Hodgkin lymphoma of the maxillary sinus Case report and literature review CONCLUSION: This is one of the few reports of extranodal Hodgkin lymphoma of the maxillary sinus. To our knowledge, this report represents the longest follow-up of any patient with this presentation. 7/28/2018
Lijing Sun, Meijun Si, Xinyan Liu, Jong Min Choi, Yanlin Wang, Sandhya S Thomas, Hui Peng, Zhaoyong Hu Long-noncoding RNA Atrolnc-1 promotes muscle wasting in mice with chronic kidney disease CONCLUSIONS: Our findings provide evidence that lncRNAs initiates the pathophysiological process of muscle wasting. The interaction between Atrolnc-1 and NF-κB signalling modulates muscle mass and proteolysis in CKD and perhaps other catabolic conditions. 7/26/2018
Weiming Xiang, Hoang-Dung Tran, Taylor T Johnson Output Reachable Set Estimation and Verification for Multilayer Neural Networks In this brief, the output reachable estimation and safety verification problems for multilayer perceptron (MLP) neural networks are addressed. First, a conception called maximum sensitivity is introduced, and for a class of MLPs whose activation functions are monotonic functions, the maximum sensiti... 7/12/2018
Gustavo Thalmer M Silva, Suma S Thomas, Cassio Pacheco Silva, Jan C Schlothauer, Mauricio S Baptista, Adilson A Freitas, Cornelia Bohne, Frank H Quina Triplet Excited States and Singlet Oxygen Production by Analogs of Red Wine Pyranoanthocyanins During the maturation of red wines, the anthocyanins of grapes are transformed into pyranoanthocyanins, which possess a pyranoflavylium cation as their basic chromophore. Photophysical properties of the singlet and triplet excited states of a series of synthetic pyranoflavylium cations were determin... 7/7/2018
Hung Fu Tseng, Lina S Sy, Lei Qian, In-Lu A Liu, Cheryl Mercado, Bruno Lewin, Sara Y Tartof, Jennifer Nelson, Lisa A Jackson, Matthew F Daley, Eric Weintraub, Nicola P Klein, Edward Belongia, Elizabeth G Liles, Steven J Jacobsen Pneumococcal Conjugate Vaccine Safety in Elderly Adults CONCLUSIONS: These data do not support an increased rate of adverse events following PCV13 administration in elders compared with PPSV23 and should provide reassurance regarding continued use of PCV13. 7/7/2018
Naren Ramakrishna, Sarah Temin, Sarat Chandarlapaty, Jennie R Crews, Nancy E Davidson, Francisco J Esteva, Sharon H Giordano, Jeffrey J Kirshner, Ian E Krop, Jennifer Levinson, Shanu Modi, Debra A Patt, Jane Perlmutter, Eric P Winer, Nancy U Lin Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases ASCO Clinical Practice Guideline Update Purpose To update the formal expert consensus-based guideline recommendations for practicing oncologists and others on the management of brain metastases for patients with human epidermal growth factor receptor 2-positive advanced breast cancer to 2018. Methods An Expert Panel conducted a targeted s... 6/26/2018
Sharon H Giordano, Sarah Temin, Sarat Chandarlapaty, Jennie R Crews, Francisco J Esteva, Jeffrey J Kirshner, Ian E Krop, Jennifer Levinson, Nancy U Lin, Shanu Modi, Debra A Patt, Jane Perlmutter, Naren Ramakrishna, Eric P Winer, Nancy E Davidson Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer ASCO Clinical Practice Guideline Update Purpose To update evidence-based guideline recommendations for practicing oncologists and others on systemic therapy for patients with human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer to 2018. Methods An Expert Panel conducted a targeted systematic literature review (f... 6/26/2018
Chengyi Zheng, Yi Luo, Cheryl Mercado, Lina Sy, Steven J Jacobsen, Brad Ackerson, Bruno Lewin, Hung Fu Tseng Using natural language processing for identification of herpes zoster ophthalmicus cases to support population-based study CONCLUSIONS AND RELEVANCE: We developed and validated an automatic method to identify HZO cases with high accuracy. As one of the largest studies on HZO, our finding emphasizes the importance of preventing HZ in the elderly population. This method can be a valuable tool to support population-based s... 6/20/2018
Renata Ferrarotto, William N William, Jennifer E Tseng, Shanthi Marur, Dong M Shin, Barbara Murphy, Ezra E W Cohen, Christopher Y Thomas, Richard Willey, Jan Cosaert, Nusrat Harun, J Jack Lee, Ignacio W Wistuba, Robert I Haddad, Bonnie S Glisson Randomized phase II trial of cixutumumab alone or with cetuximab for refractory recurrentmetastatic head and neck squamous cell carcinoma CONCLUSION: The results of this study do not support the use of cixutumumab alone or with cetuximab in unselected patients with R/M HNSCC. 6/19/2018
Aileen C Johnson, Cecilia G Ethun, Yuan Liu, Alexandra G Lopez-Aguiar, Thuy B Tran, George Poultsides, Valerie Grignol, J Harrison Howard, Meena Bedi, T Clark Gamblin, Jennifer Tseng, Kevin K Roggin, Konstantinos Chouliaras, Konstantinos Votanopoulos, Darren Cullinan, Ryan C Fields, Keith A Delman, William C Wood, Kenneth Cardona, Shishir K Maithel Studying a Rare Disease Using Multi-Institutional Research Collaborations vs Big Data Where Lies the Truth CONCLUSIONS: Granular data afforded by collaborative research enables in-depth analysis of patient outcomes. The NCDB, although powered with large numbers, cannot assess many relevant outcomes (eg recurrence, DSS, or complications). In this study, the approaches yielded conflicting results. The USSC... 6/16/2018
He J Zhu, Bradford S Hoppe, Stella Flampouri, Debbie Louis, John Pirris, R Charles Nichols, Randal H Henderson, Catherine E Mercado Rationale and early outcomes for the management of thymoma with proton therapy CONCLUSIONS: PT achieved superior dose sparing to the heart, lung, and esophagus compared to IMRT for thymic malignancies. Patients treated with PT had few radiation-induced toxicities and similar survival compared to historic proton data. 6/8/2018
Charles C Peyton, Mounsif Azizi, Juan Chipollini, Cesar Ercole, Mayer Fishman, Scott M Gilbert, Timothy Juwono, Jorge Lockhart, Michael Poch, Julio M Pow-Sang, Philippe E Spiess, Lucas Wiegand, Wade J Sexton Survival Outcomes Associated With Female Primary Urethral Carcinoma Review of a Single Institutional Experience CONCLUSIONS: Locally advanced female PUC has relatively poor survival outcomes. Although we observed a nonsignificant interval improvement in survival with multimodality therapy, the treatment paradigm is inconsistent. Because it is a rare disease, collaborative multi-institutional studies are neede... 6/4/2018
Gerard J Criner, Richard Sue, Shawn Wright, Mark Dransfield, Hiram Rivas-Perez, Tanya Wiese, Frank C Sciurba, Pallav L Shah, Momen M Wahidi, Hugo Goulart de Oliveira, Brian Morrissey, Paulo F G Cardoso, Steven Hays, Adnan Majid, Nicholas Pastis, Lisa Kopas, Mark Vollenweider, P Michael McFadden, Michael Machuzak, David W Hsia, Arthur Sung, Nabil Jarad, Malgorzata Kornaszewska, Stephen Hazelrigg, Ganesh Krishna, Brian Armstrong, Narinder S Shargill, Dirk-Jan Slebos, LIBERATE Study Group A Multicenter Randomized Controlled Trial of Zephyr Endobronchial Valve Treatment in Heterogeneous Emphysema LIBERATE CONCLUSIONS: Zephyr EBV provides clinically meaningful benefits in lung function, exercise tolerance, dyspnea, and quality of life out to at least 12 months, with an acceptable safety profile in patients with little or no collateral ventilation in the target lobe. Clinical trial registered with www.... 5/23/2018
Tiffany A Chen, Carmel L Mercado, Katie L Topping, Benjamin P Erickson, Kimberly P Cockerham, Andrea L Kossler Disseminated silicone granulomatosis in the face and orbit CONCLUSIONS: Silicone can induce a severe, systemic inflammatory response and should be considered in the differential for facial and periorbital granulomas in patients with a history of silicone breast implants. Management of disseminated silicone granulomatosis is challenging and requires multimod... 5/22/2018
Marianne Salas, Cristina Lucena, Luis Javier Herrera, Ana Yebra, Alvaro Della Bona, María M Pérez Translucency thresholds for dental materials OBJECTIVE: To determine the translucency acceptability and perceptibility thresholds for dental resin composites using CIEDE2000 and CIELAB color difference formulas. 5/17/2018
Juan Manuel Gálvez, Daniel Castillo, Luis Javier Herrera, Belén San Román, Olga Valenzuela, Francisco Manuel Ortuño, Ignacio Rojas Multiclass classification for skin cancer profiling based on the integration of heterogeneous gene expression series Most of the research studies developed applying microarray technology to the characterization of different pathological states of any disease may fail in reaching statistically significant results. This is largely due to the small repertoire of analysed samples, and to the limitation in the number o... 5/12/2018
Razvan Ghinea, Luis Javier Herrera, María M Pérez, Ana M Ionescu, Rade D Paravina Gingival shade guides Colorimetric and spectral modeling CONCLUSIONS: An increase in the number of clusters in the gingival shade guide models was associated with a decrease in coverage error (better match) to human gingiva. Gingival shade guide models with only 4 tabs provided a CIELAB and CIEDE2000 coverage error lower than the acceptability threshold f... 4/19/2018
Catherine E Mercado, Peter A Drew, Christopher G Morris, Peter T Dziegielewski, William M Mendenhall, Robert J Amdur Positive Surgical Margins in Favorable-Stage Differentiated Thyroid Cancer CONCLUSIONS: Cure with a microscopically positive margin was suboptimal (71%) despite patients having classic-histology papillary and follicular carcinoma, favorable stage, and moderate-dose I-131 therapy. 4/18/2018
Stijn van Roessel, Gyulnara G Kasumova, Omidreza Tabatabaie, Sing Chau Ng, L Bengt van Rijssen, Joanne Verheij, Robert M Najarian, Thomas M van Gulik, Marc G Besselink, Olivier R Busch, Jennifer F Tseng Pathological Margin Clearance and Survival After Pancreaticoduodenectomy in a US and European Pancreatic Center CONCLUSIONS: In patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma, a margin clearance of ≥1 mm correlates with improved survival relative to < 1 mm clearance and may be a more accurate predictor of a complete margin-negative resection in pancreatic cancer. The type of margin ... 4/14/2018
Afeesh Rajan Unnithan, Arathyram Ramachandra Kurup Sasikala, Shalom Sara Thomas, Amin Ghavami Nejad, Youn Soo Cha, Chan Hee Park, Cheol Sang Kim Strategic Design and Fabrication of Biomimetic 3D Scaffolds Unique Architectures of Extracellular Matrices for Enhanced Adipogenesis and Soft Tissue Reconstruction The higher rate of soft tissue impairment due to lumpectomy or other trauma greatly requires the restoration of the irreversibly lost subcutaneous adipose tissues. The nanofibers fabricated by conventional electrospinning provide only a superficial porous structure due to its sheet like 2D structure... 4/11/2018
Asaf D Yanir, Imelda C Hanson, William T Shearer, Lenora M Noroski, Lisa R Forbes, Feliz O Seeborg, Sarah Nicholas, Ivan Chinn, Jordan S Orange, Nicholas L Rider, Kathryn S Leung, Swati Naik, George Carrum, Ghadir Sasa, Meenakshi Hegde, Bilal A Omer, Nabil Ahmed, Carl E Allen, Yassine Khaled, Meng-Fen Wu, Hao Liu, Stephen M Gottschalk, Helen E Heslop, Malcolm K Brenner, Robert A Krance, Caridad A Martinez High Incidence of Autoimmune Disease after Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease There is a lack of consensus regarding the role and method of hematopoietic stem cell transplantation (HSCT) on patients with chronic granulomatous disease (CGD). Long-term follow-up after HSCT in these patient population is essential to know its potential complications and decide who will benefit t... 4/10/2018
Fabian Meder, Steffi S Thomas, Tobias Bollhorst, Kenneth A Dawson Ordered Surface Structuring of Spherical Colloids with Binary Nanoparticle Superlattices Surface-patterning colloidal matter in the sub-10 nm regime generates exceptional functionality in biology and photonic and electronic materials. Techniques of artificially generating functional patterns in the small nanoscale advanced in a fascinating manner in the last several years. However, they... 3/27/2018
Ayòtúndé B Fadayomi, Gyulnara G Kasumova, Omidreza Tabatabaie, Susanna W L de Geus, Tara S Kent, Sing Chau Ng, A James Moser, Mark P Callery, Stanley W Ashley, Jennifer F Tseng Unique predictors and economic burden of superficial and deeporgan space surgical site infections following pancreatectomy CONCLUSION: Deep/organ space SSI contributes more profoundly to prolonged hospital stay, readmission, and additional costs, suggesting that strategies should focus on preferential prevention of deep/organ space infections. 3/13/2018
Carla I Mercado, Edward Gregg, Cathleen Gillespie, Fleetwood Loustalot Trends in lipid profiles and descriptive characteristics of US adults with and without diabetes and cholesterol-lowering medication use-National Health and Nutrition Examination Survey, 2003-2012, United States CONCLUSIONS: Diabetic adults were more likely to have lower lipid levels, except for triglyceride levels, than non-diabetic adults with profound differences when considering cholesterol medication use, possibly due to the positive effects from clinical diabetes management. 3/7/2018
Karen R Siegel, Kai McKeever Bullard, Giuseppina Imperatore, Mohammed K Ali, Ann Albright, Carla I Mercado, Rui Li, Edward W Gregg Prevalence of Major Behavioral Risk Factors for Type 2 Diabetes CONCLUSIONS: A small proportion of U.S. adults engages in risk reduction behaviors. Research and interventions targeted at young and less-educated segments of the population may help close gaps in risk reduction behaviors. 3/4/2018
Yuk Pheel Park, Linchun Jin, Katie B Bennett, Dunrui Wang, Kristianna M Fredenburg, Jennifer E Tseng, Lung-Ji Chang, Jianping Huang, Edward K L Chan CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma CONCLUSION: CD70-specific CAR-T cells specifically recognized and efficiently eliminated CD70-positive HNSCC cells. This study provides the basis for further investigation into CD70 and other CAR-T targets. 3/3/2018
Cameron W Swanick, Xiudong Lei, Ying Xu, Yu Shen, Nathan A Goodwin, Grace L Smith, Sharon H Giordano, Kelly K Hunt, Reshma Jagsi, Simona F Shaitelman, Susan K Peterson, Benjamin D Smith Long-term Patient-Reported Outcomes in Older Breast Cancer Survivors A Population-Based Survey Study CONCLUSIONS: In this nationally diverse cohort, less irradiation and less surgery were associated with better long-term quality-of-life outcomes. However, patient regret regarding surgery and radiation therapy was similar across all groups. 2/28/2018
María M Pérez, Razvan Ghinea, Luis Javier Herrera, F Carrillo, Ana M Ionescu, Rade D Paravina Color difference thresholds for computer-simulated human Gingiva CONCLUSIONS: The difference between the perceptibility and acceptability threshold for gingiva was statistically significant in both CIEDE2000 and CIELAB. The same was true for differences between the corresponding thresholds using two color difference formulas, and between dentists and laypersons. ... 2/25/2018
Patrick Louchouarn, Shaya M Seward, Gerard Cornelissen, Hans Peter H Arp, Kevin M Yeager, Robin Brinkmeyer, Peter H Santschi Limited mobility of dioxins near San Jacinto super fund site waste pit in the Houston Ship Channel, Texas due to strong sediment sorption Sediments from a waste pit in Houston Ship Channel (HSC) were characterized using a number of molecular markers of natural organic matter fractions (e.g., pyrogenic carbon residues, PAHs, lignins), in addition to dioxins, in order to test the hypothesis that the dispersal and mobility of dioxins fro... 2/25/2018
Virginia Wedell Osborn, Babak Givi, Justin Rineer, Dylan Roden, Niki Sheth, Ariel Lederman, Evangelia Katsoulakis, Kenneth Hu, David Schreiber Patterns of care and outcomes of adjuvant therapy for high-risk head and neck cancer after surgery CONCLUSION: Postoperative CRT seems underutilized with positive margins and/or ECE and overutilized without positive margins and/or ECE. The CRT was associated with improved OS but the benefit persisted only in the subset with positive margins and/or ECE. 2/17/2018
Susanna W L de Geus, Gyulnara G Kasumova, Teviah E Sachs, Sing Chau Ng, Tara S Kent, A James Moser, Alexander L Vahrmeijer, Mark P Callery, Jennifer F Tseng Neoadjuvant therapy affects margins and margins affect all perioperative and survival outcomes in resected pancreatic adenocarcinoma BACKGROUND: Resection margin status is an important prognostic factor in pancreatic cancer; however, the impact of positive resection margins in those who received neoadjuvant therapy remains unclear. The current study investigates the prognostic impact of resection margin status after neoadjuvant t... 2/11/2018
Harold Watson, Ariel Perez, Kwabena Ayesu, Faisal Musa, Jose Sarriera, Mario Madruga, Steve J Carlan Inherited factor II deficiency with paradoxical hypercoagulability a case report : Congenital deficiency of factor II is a very rare autosomal recessive disorder that can result in a bleeding diathesis. Genotypically, individuals are either homozygous for a defective prothrombin gene or a compound heterozygote with different mutated prothrombin genes inherited from each parent. ... 2/2/2018
S Seward Anti-N-methyl-D-aspartate receptor antibody encephalitis An important cause of encephalitis in young adults A report of two cases Encephalitis is a clinical syndrome which can include altered mental status, motor and sensory deficits, altered behavior including personality changes, speech and movement disorders and seizures. While the overall incidence of encephalitis is not known, it is common enough that most pediatric and a... 2/1/2018
Mario Matiotti-Neto, Mariam F Eskander, Omidreza Tabatabaie, Gyulnara Kasumova, Lindsay A Bliss, Sing Chau Ng, Nicholas E Tawa, Blanche Murphy, Jonathan F Critchlow, Jennifer F Tseng Percutaneous emversusem Cut-Down Technique for Indwelling Port Placement The superiority of surgical cut-down of the cephalic vein versus percutaneous catheterization of the subclavian vein for the insertion of totally implantable venous access devices (TIVADs) is debated. To compare the safety and efficacy of surgical cut-down versus percutaneous placement of TIVADs. Th... 1/17/2018
Shimwoo Lee, Cecilia L Mercado, Joan F Cangiarella, Chloe M Chhor Frequency and outcomes of biopsy-proven fibroadenomas recommended for surgical excision Our aim was to investigate the outcomes of fibroadenomas recommended for surgical excision due to large size (>2cm) or interval growth. A retrospective review of our institutional radiology database from 2007 to 2015 was performed. We identified 167 biopsy-proven fibroadenomas recommended for surgic... 12/20/2017
Joseph A Reza, Shani Fruchter, Shyam Varadarajulu, J Pablo Arnoletti A Large Intussuscepting Gastric Lipoma Lipomas of the lower foregut are exceptionally rare. Presenting symptoms often include bleeding, weight loss, and obstructive symptoms. Surgical resection remains the standard treatment. We report a case of a large intussuscepting gastric lipoma. 12/20/2017
Susanna W L de Geus, Gyulnara G Kasumova, Mariam F Eskander, Sing Chau Ng, Tara S Kent, A James Moser, Alexander L Vahrmeijer, Mark P Callery, Jennifer F Tseng Is Neoadjuvant Therapy Sufficient in Resected Pancreatic Cancer Patients A National Study CONCLUSIONS: Our results using national data suggest that after receipt of neoadjuvant therapy and pancreatectomy, additional postoperative therapy may not provide additional survival benefit. These data warrant further prospective data collection and consideration for clinical trials. 12/14/2017
Jaymin Jhaveri, Yuan Liu, Mudit Chowdhary, Zachary S Buchwald, Theresa W Gillespie, Jeffrey J Olson, Alfredo D Voloschin, Bree R Eaton, Hui-Kuo G Shu, Ian R Crocker, Walter J Curran, Kirtesh R Patel Is less more Comparing chemotherapy alone with chemotherapy and radiation for high-risk grade 2 glioma An analysis of the National Cancer Data Base CONCLUSIONS: No long-term OS difference was seen in patients with high-risk grade 2 gliomas treated with CA versus CRT. These findings are hypothesis-generating, and prospective clinical trials comparing these treatment paradigms are warranted. Cancer 2018;124:1169-78. © 2017 American Cancer Society... 12/6/2017
Lily Zhang, Carolina Mercado, Anat Galor, Edward J Holland, Gaofeng Wang, Carol L Karp Challenging Treatment of Ocular Surface Squamous Neoplasia in Patients with Atopic Disease CONCLUSION: We report on three patients with a history of atopy whose OSSN presentation and course was challenging. Overall, our cases responded better to topical 5-fluorouracil compared to topical interferon-alpha-2b, but recurrences were common. These patients may benefit from more aggressive and ... 12/1/2017
Daniel Castillo, Juan Manuel Gálvez, Luis Javier Herrera, Belén San Román, Fernando Rojas, Ignacio Rojas Integration of RNA-Seq data with heterogeneous microarray data for breast cancer profiling CONCLUSIONS: This work proposes a novel data integration stage in the traditional gene expression analysis pipeline through the combination of heterogeneous data from microarrays and RNA-Seq technologies. Available samples have been successfully classified using a subset of six genes obtained by a f... 11/22/2017
Patrick L Garcia, Aubrey L Miller, Tracy L Gamblin, Leona N Council, John D Christein, J Pablo Arnoletti, Marty J Heslin, Sushanth Reddy, Joseph H Richardson, Xiangqin Cui, Robert C A M van Waardenburg, James E Bradner, Eddy S Yang, Karina J Yoon JQ1 Induces DNA Damage and Apoptosis, and Inhibits Tumor Growth in a Patient-Derived Xenograft Model of Cholangiocarcinoma Cholangiocarcinoma (CCA) is a fatal disease with a 5-year survival of <30%. For a majority of patients, chemotherapy is the only therapeutic option, and virtually all patients relapse. Gemcitabine is the first-line agent for treatment of CCA. Patients treated with gemcitabine monotherapy survive ∼8 ... 11/17/2017
Zhi Rong Qian, Douglas A Rubinson, Jonathan A Nowak, Vicente Morales-Oyarvide, Richard F Dunne, Margaret M Kozak, Marisa W Welch, Lauren K Brais, Annacarolina Da Silva, Tingting Li, Wanwan Li, Atsuhiro Masuda, Juhong Yang, Yan Shi, Mancang Gu, Yohei Masugi, Justin Bui, Caitlin L Zellers, Chen Yuan, Ana Babic, Natalia Khalaf, Andrew Aguirre, Kimmie Ng, Rebecca A Miksad, Andrea J Bullock, Daniel T Chang, Jennifer F Tseng, Thomas E Clancy, David C Linehan, Jennifer J Findeis-Hosey, Leona A Doyle, Aaron R Thorner, Matthew Ducar, Bruce Wollison, Angelica Laing, William C Hahn, Matthew Meyerson, Charles S Fuchs, Shuji Ogino, Jason L Hornick, Aram F Hezel, Albert C Koong, Brian M Wolpin Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma CONCLUSIONS AND RELEVANCE: Patient outcomes are associated with alterations of the 4 main driver genes in resected pancreatic adenocarcinoma. 11/4/2017
Arun Kalava, Abby M Pribish, Lucas R Wiegand Pudendal nerve blocks in men undergoing urethroplasty a case series The pudendal nerve block (PNB) is widely used for regional anesthesia during obstetric and anorectal procedures, but its role in urologic procedures has not been thoroughly studied. While transvaginal PNB is relatively straightforward, PNB in male patients often requires imaging guidance due to diff... 11/2/2017
Carla I Mercado, Mary E Cogswell, Cria G Perrine, Cathleen Gillespie Diet Quality Associated with Total Sodium Intake among US Adults Aged 18 Years-National Health and Nutrition Examination Survey, 2009-2012 Diet quality or macronutrient composition of total daily sodium intake (dNa) <2300 mg/day in the United States (US) is unknown. Using data from 2011-2014 NHANES (National Health and Nutrition Examination Survey), we examined 24-h dietary recalls (n = 10,142) from adults aged ≥18 years and investigat... 10/26/2017
Todd A Pezzi, Chad Tang, Cameron W Swanick, Penny Fang, Kenneth Hess, Ting Xu, Stephen M Hahn, Joe Y Chang, Zhongxing Liao, Daniel Gomez Patterns and correlates of treatment failure in relation to isodose distribution in non-small cell lung cancer An analysis of 1522 patients in the modern era CONCLUSION: In this large study of patients treated in the modern era with varying dose fractionation regimens, higher BED was associated with improved freedom from in-field failure, and that this relationship appeared to be consistent with the classically described sigmoid shape. We also found that... 10/22/2017
Ujas Parikh, Chloe M Chhor, Cecilia L Mercado Ductal Carcinoma In Situ The Whole Truth CONCLUSION: Studies have aimed to assess prognostic factors to characterize its risk of invasive potential; however, there still remains a lack of uniformity in workup and treatment. We summarize current knowledge of DCIS and the ongoing controversies. 10/19/2017
Vicente Morales-Oyarvide, Douglas A Rubinson, Richard F Dunne, Margaret M Kozak, Justin L Bui, Chen Yuan, Zhi Rong Qian, Ana Babic, Annacarolina Da Silva, Jonathan A Nowak, Natalia Khalaf, Lauren K Brais, Marisa W Welch, Caitlin L Zellers, Kimmie Ng, Daniel T Chang, Rebecca A Miksad, Andrea J Bullock, Jennifer F Tseng, Richard S Swanson, Thomas E Clancy, David C Linehan, Jennifer J Findeis-Hosey, Leona A Doyle, Jason L Hornick, Shuji Ogino, Charles S Fuchs, Aram F Hezel, Albert C Koong, Brian M Wolpin Lymph node metastases in resected pancreatic ductal adenocarcinoma predictors of disease recurrence and survival CONCLUSIONS: American Joint Committee on Cancer 8th edition LN classification is an effective and practical tool to predict outcomes in patients with resected PDAC. However, the prognostic value of LN metastases is attenuated in patients with positive resection margins and distal pancreatectomies. 10/6/2017
Jennifer Tseng, Mitchell C Posner An Update on Randomized Clinical Trials in Gastric Cancer The optimal treatment of esophageal cancer is still being defined. The timing of surgical management and the application of chemotherapy and radiation in the neoadjuvant and adjuvant settings have been studied in several prospective, randomized, controlled trials. This article outlines some of the h... 9/20/2017
Maarten R Struyvenberg, Zhi Ven Fong, Camilia R Martin, Jennifer F Tseng, Thomas E Clancy, Carlos Fernández-Del Castillo, Hanna J Tillman, Melena D Bellin, Steven D Freedman Impact of Treatments on Diabetic Control and Gastrointestinal Symptoms After Total Pancreatectomy CONCLUSIONS: After TP, CSII therapy is safe compared with MDIs in T3cDM and not associated with an increase in severe hypoglycemic events. Pancreatic enzyme replacement therapy is highly variable with low doses associated with unintentional weight loss and gastrointestinal symptoms. 9/14/2017
Lainie P Martin, Jason A Konner, Kathleen N Moore, Shelly M Seward, Ursula A Matulonis, Raymond P Perez, Ying Su, Anna Berkenblit, Rodrigo Ruiz-Soto, Michael J Birrer Characterization of folate receptor alpha FR expression in archival tumor and biopsy samples from relapsed epithelial ovarian cancer patients A phase I expansion study of the FR-targeting antibody-drug conjugate mirvetuximab soravtansine CONCLUSION: Concordance of FRα expression in biopsy versus archival tumor samples suggests that archival tissue can reliably identify patients with receptor-positive tumors and is appropriate for patient selection in mirvetuximab soravtansine clinical trials. Regardless of the tissue source analyzed... 8/28/2017
Jason Lang, Laurie Cluff, Jennifer Rineer, Darigg Brown, Nkenge Jones-Jack Building Capacity for Workplace Health Promotion Findings From the WorkHealth Train-the-Trainer Program Small- and mid-sized employers are less likely to have expertise, capacity, or resources to implement workplace health promotion programs, compared with large employers. In response, the Centers for Disease Control and Prevention developed the Work@Health^(®) employer training program to determine t... 8/23/2017
Laurie A Cluff, Jason E Lang, Jennifer R Rineer, Nkenge H Jones-Jack, Karen M Strazza Training Employers to Implement Health Promotion Programs Results From the CDC WorkHealth Program CONCLUSION: The Work@Health Program provided employers with knowledge to implement WHP interventions. The training and technical assistance provided structure, practical guidance, and tools to assess needs and select, implement, and evaluate interventions. 7/22/2017
Susanna W L de Geus, Mariam F Eskander, Gyulnara G Kasumova, Sing Chau Ng, Tara S Kent, Joseph D Mancias, Mark P Callery, Anand Mahadevan, Jennifer F Tseng Stereotactic body radiotherapy for unresected pancreatic cancer A nationwide review CONCLUSIONS: SBRT is associated with a significantly better outcome than chemotherapy alone or in conjunction with traditional EBRT. These results support the idea that SBRT is a promising treatment approach for patients with unresected pancreatic cancer. Cancer 2017;123:4158-4167. © 2017 American C... 7/15/2017
Gyulnara G Kasumova, Omidreza Tabatabaie, Robert M Najarian, Mark P Callery, Sing Chau Ng, Andrea J Bullock, Robert A Fisher, Jennifer F Tseng Surgical Management of Gallbladder Cancer Simple Versus Extended Cholecystectomy and the Role of Adjuvant Therapy CONCLUSIONS: Adjuvant therapy prolongs survival after resection of T2/T3 tumors. Simple cholecystectomy with adjuvant therapy appears to be superior to extended resection alone in the short term and may serve as a potential alternative to re-resection in select high-risk individuals. 7/11/2017
Caitlin Mason, Lei Wang, Catherine Duggan, Ikuyo Imayama, Sushma S Thomas, Ching-Yun Wang, Larissa A Korde, Anne McTiernan Gene expression in breast and adipose tissue after 12 months of weight loss and vitamin D supplementation in postmenopausal women Adipose tissue is involved in the etiology of postmenopausal breast cancer, possibly through increased sex steroid hormone production, inflammation, and altered adipokines. Vitamin D may affect these pathways but its effect on gene expression in different tissues has not been examined. Within a doub... 6/27/2017
Daniel Christiadi, Chari Mercado, Richard Singer Regional citrate anticoagulation in membrane based plasma exchange Safety, efficacy and effect on calcium balance CONCLUSION: Regional citrate anticoagulated membrane separation plasma exchange can be performed safely and effectively without the need for post filter ionized calcium monitoring. The algorithm employed resulted in a net calcium gain. 6/16/2017
Afshan A Nanji, Carolina Mercado, Anat Galor, Sander Dubovy, Carol L Karp Updates in Ocular Surface Tumor Diagnostics CONCLUSIONS: Histology remains the gold standard for diagnosis for all 3 of these malignancies. However, multiple diagnostic techniques are available to assist in making preliminary and early diagnoses, in differentiating between similar-appearing lesions, and in some cases, avoiding biopsy prior to... 6/8/2017
Ismail Mert, Jasdeep Chhina, Ghassan Allo, Jing Dai, Shelly Seward, Mark S Carey, Marta Llaurado, Shailendra Giri, Ramandeep Rattan, Adnan R Munkarah Synergistic effect of MEK inhibitor and metformin combination in low grade serous ovarian cancer CONCLUSIONS: Metformin alone or in combination with MEK and glycolytic inhibitors may be a potential therapy for LGSOC, a cancer that is indolent but chemo-resistant. 5/27/2017
Nosayaba Osazuwa-Peters, Eric Adjei Boakye, Adnan S Hussaini, Nanthiya Sujijantarat, Rajan N Ganesh, Matthew Snider, Devin Thompson, Mark A Varvares Characteristics and predictors of oral cancer knowledge in a predominantly African American community CONCLUSIONS: There was lower oral cancer knowledge among African Americans and those with low education. The prevalence of smoking was also very high. Understanding predictors of oral cancer knowledge is important in future design of educational interventions specifically targeted towards high-risk ... 5/26/2017
Omidreza Tabatabaie, Gyulnara G Kasumova, Tara S Kent, Mariam F Eskander, Ayotunde B Fadayomi, Sing Chau Ng, Jonathan F Critchlow, Nicholas E Tawa, Jennifer F Tseng Upper extremity deep venous thrombosis after port insertion What are the risk factors CONCLUSION: This study identified major risk factors of upper extremity deep venous thrombosis. Further studies are needed to evaluate the appropriateness of thromboprophylaxis in patients at greater risk of upper extremity deep venous thrombosis. 5/25/2017
Suma S Thomas, Hao Tang, Adam Gaudes, Signe B Baggesen, Corinne L D Gibb, Bruce C Gibb, Cornelia Bohne Tuning the Binding Dynamics of a Guest-Octaacid Capsule through Noncovalent Anchoring Hydrophobic or hydrophilic substituents have different effects on the binding dynamics of pyrene derivatives with a 2:1 capsule formed from two octaacid cavitands, showing a subtle interplay of different kinetic factors. Anchoring of the methyl group of 1-methylpyrene within one cavitand slowed the ... 5/24/2017
Xinyan Liu, Rizhen Yu, Lijing Sun, Giacomo Garibotto, Xia Lin, Yanlin Wang, Sandhya S Thomas, Rongshan Li, Zhaoyong Hu The nuclear phosphatase SCP4 regulates FoxO transcription factors during muscle wasting in chronic kidney disease Chronic kidney disease (CKD) and related inflammatory responses stimulate protein-energy wasting, a complication causing loss of muscle mass. Primarily, muscle wasting results from accelerated protein degradation via autophagic/lysosomal and proteasomal pathways, but mechanisms regulating these prot... 5/17/2017
Cameron W Swanick, Patricia J Eifel, Jinhai Huo, Larissa A Meyer, Grace L Smith Challenges to delivery and effectiveness of adjuvant radiation therapy in elderly patients with node-positive vulvar cancer CONCLUSIONS: In this cohort of older women with node-positive vulvar cancer, achieving metrics for RT delivery was an important factor for optimizing disease benefits from treatment. 5/17/2017
Y Al Khaled, S Tierling, M Laqqan, C Lo Porto, M E Hammadeh Cigarette smoking induces only marginal changes in sperm DNA methylation levels of patients undergoing intracytoplasmic sperm injection treatment DNA methylation plays important roles in genome stability and regulation of gene expression. This study was designed to determine the influence of cigarette smoking on sperm DNA methylation. From a genome-wide survey on sperm samples, differentially methylated target CpGs should be selected and subj... 5/16/2017
Gyulnara G Kasumova, Mariam F Eskander, Susanna W L de Geus, Mario Matiotti Neto, Omidreza Tabatabaie, Sing Chau Ng, Rebecca A Miksad, Anand Mahadevan, James R Rodrigue, Jennifer F Tseng Regional variation in the treatment of pancreatic adenocarcinoma Decreasing disparities with multimodality therapy CONCLUSION: Regional variations exist in pancreatic cancer treatment and survival. While providing multimodality cancer-directed therapy can help mitigate these differences, survival with pancreatic cancer needs to be interpreted in the context of overall health, underlying risk factors, and life ex... 5/11/2017
Steffi S Thomas, Matthew Coleman, Emma Carroll, Ester Polo, Fabian Meder, Kenneth A Dawson Locating Reactive Groups on Nanomaterials with Gold Nanoclusters Toward a Surface Reactive Site Map Nanoparticles (NPs) are often functionalized with reactive groups such as amines and thiols for the subsequent conjugation of further molecules, e.g., stabilizing polymers, drugs, and proteins for targeting cells or specific diseases. In addition to the quantitative estimation of the reactive conjug... 5/3/2017
Kathleen N Moore, Hossein Borghaei, David M O'Malley, Woondong Jeong, Shelly M Seward, Todd M Bauer, Raymond P Perez, Ursula A Matulonis, Kelli L Running, Xiaoyan Zhang, Jose F Ponte, Rodrigo Ruiz-Soto, Michael J Birrer Phase 1 dose-escalation study of mirvetuximab soravtansine IMGN853, a folate receptor -targeting antibody-drug conjugate, in patients with solid tumors CONCLUSIONS: IMGN853 demonstrated a manageable safety profile and encouraging preliminary clinical activity, particularly in patients with ovarian cancer. The results establish a recommended phase 2 dosing of 6.0 mg/kg (based on adjusted ideal body weight) once every 3 weeks. Cancer 2017. © 2017 Ame... 4/26/2017
Penny Fang, Cameron W Swanick, Todd A Pezzi, Zhongxing Liao, James Welsh, Steven H Lin, Daniel R Gomez Outcomes and toxicity following high-dose radiation therapy in 15 fractions for non-small cell lung cancer CONCLUSIONS: AHRT in 15 fractions can be safe and effective. Consideration for using AHRT with immunotherapy and sequential chemotherapy for improved out-of-radiation field and distant control is warranted. 4/22/2017
Jennifer Tseng, Alexandra Kyrillos, Erik Liederbach, Georgia G Spear, Jacob Ecanow, Chi-Hsiung Wang, Tom Czechura, Olga Kantor, Megan Miller, David J Winchester, Catherine E Pesce, Sarah Rabbitt, Katharine Yao Clinical accuracy of preoperative breast MRI for breast cancer CONCLUSIONS: Breast MRI provides greater accuracy for a third of patients undergoing preoperative MGM and U/S. Mammographic calcifications were associated with MRI clinical accuracy for patients with invasive cancer. 4/15/2017
Meir Mizrahi, Jennifer F Tseng, Daniel Wong, Nadine Tung, Mariam F Eskander, Tyler M Berzin, Douglas K Pleskow, Mandeep S Sawhney Chronic Pancreatitis-Like Change in BRCA2 Mutation Carriers CONCLUSIONS: Chronic pancreatitis-like changes, along with solid and cystic pancreatic lesions, were significantly more common in BRCA2 mutation carriers than in noncarriers. 4/5/2017
Julio Slongo, Lucas R Wiegand Pancake Kidney With Obstructed Moiety A Rare Renal Fusion Anomaly Renal fusion abnormalities are rare. Even more rare is pancake kidney. We present a case of a 28-year-old male with symptomatic obstruction of a non-functioning moiety of a pancake kidney. He underwent ureterectomy with a finding of only atretic renal parenchyma at exploration. He recovered well and... 4/5/2017
Janice M Leung, Pei Yee Tiew, Micheál Mac Aogáin, Kurtis F Budden, Valerie Fei Lee Yong, Sangeeta S Thomas, Kevin Pethe, Philip M Hansbro, Sanjay H Chotirmall The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD COPD is a major global concern, increasingly so in the context of ageing populations. The role of infections in disease pathogenesis and progression is known to be important, yet the mechanisms involved remain to be fully elucidated. While COPD pathogens such as Haemophilus influenzae, Moraxella cat... 3/26/2017
Susanna W L de Geus, Mariam F Eskander, Lindsay A Bliss, Gyulnara G Kasumova, Sing Chau Ng, Mark P Callery, Jennifer F Tseng Neoadjuvant therapy versus upfront surgery for resected pancreatic adenocarcinoma A nationwide propensity score matched analysis CONCLUSION: The survival impact of neoadjuvant therapy is stage-dependent. Neoadjuvant therapy does not disadvantage survival compared with conventional upfront surgery followed by adjuvant therapy in any stage, and is associated with a significant survival advantage in stage III pancreatic cancer. 3/26/2017
Chris Erwin G Mercado, Nattwut Ekapirat, Arjen M Dondorp, Richard J Maude An assessment of national surveillance systems for malaria elimination in the Asia Pacific CONCLUSIONS: Most collected malaria incidence data in the Asia Pacific is from government health facilities while data from a wide variety of other known sources are often not included in national surveillance databases. In particular, there needs to be a concerted regional effort to support inclusi... 3/23/2017
Serena Byrd, Adnan S Hussaini, Jastin Antisdel Acute Vision Loss Following Endoscopic Sinus Surgery A 41-year-old female with a history of uterine cancer and Celiac and Raynaud's Disease presented to our institution with frequent migraines and nasal congestion. She underwent functional endoscopic sinus surgery (FESS) and experienced acute unilateral vision loss postoperatively. Rapid recognition o... 3/14/2017
Mary Masterman, Robert M Cronin, Sharon E Davis, Jared A Shenson, Gretchen P Jackson Adoption of Secure Messaging in a Patient Portal across Pediatric Specialties Few studies have explored adoption of patient portals for pediatric patients outside primary care or disease-specific applications. We examined use of patient-provider messaging in a patient portal across pediatric specialties during the three years after implementation of pediatric portal accounts ... 3/9/2017
Adam S Baumgarten, Bhavik B Shah, Trushar B Patel, Lucas R Wiegand Robotic Ileal Interposition for Radiation-induced Ureteral Stricture Disease CONCLUSION: Robotic ileal interposition is a technically feasible procedure with good functional outcomes. By using preoperative imaging to estimate length needed for ileal segment, only 1 position change is needed during surgery. 3/6/2017
Sandhya S Thomas, William E Mitch Parathyroid hormone stimulates adipose tissue browning a pathway to muscle wasting PURPOSE OF REVIEW: Studying organ-to-organ communications (i.e. crosstalk) uncovers mechanisms regulating metabolism in several tissues. What is missing is identification of mediators of different catabolic conditions contributing to losses of adipose and muscle tissues. Identifying mediators involv... 3/4/2017
Shannon E Fogh, Snehal Deshmukh, Lawrence B Berk, Amylou C Dueck, Kevin Roof, Sherif Yacoub, Thomas Gergel, Kevin Stephans, Andreas Rimner, Albert DeNittis, John Pablo, Justin Rineer, Terence M Williams, Deborah Bruner A Randomized Phase 2 Trial of Prophylactic Manuka Honey for the Reduction of Chemoradiation Therapy-Induced Esophagitis During the Treatment of Lung Cancer Results of NRG Oncology RTOG 1012 CONCLUSION: Honey as prescribed within this protocol was not superior to best supportive care in preventing radiation esophagitis. Further testing of other types of honey and research into the mechanisms of action are needed. 3/1/2017
Yazan S Khaled, Kavi Fatania, Jenifer Barrie, Nicola De Liguori, Rahul Deshpande, Derek A O'Reilly, Basil J Ammori Matched Case-Control Comparative Study of Laparoscopic Versus Open Pancreaticoduodenectomy for Malignant Lesions CONCLUSIONS: In selected patients, the laparoscopic approach to pancreaticoduodenectomy in the hands of the experienced offers advantages over open surgery without compromising the oncologic resection. 2/18/2017
Zhen Li, Candy C Mercado, Mengjin Yang, Ethan Palay, Kai Zhu Electrochemical impedance analysis of perovskite-electrolyte interfaces The flat band potentials and carrier densities of spin coated and sprayed MAPbI(3), FA(0.85)Cs(0.15)PbI(3), and MAPbBr(3) perovskite films were determined using the Mott-Schottky relation. The films developed a space charge layer and exhibited p-type conduction with a carrier concentration of ∼10^(1... 2/10/2017
Omidreza Tabatabaie, Gyulnara G Kasumova, Mariam F Eskander, Jonathan F Critchlow, Nicholas E Tawa, Jennifer F Tseng Totally Implantable Venous Access Devices A Review of Complications and Management Strategies CONCLUSIONS: Physicians should be familiar with port complications and their diagnosis and management. 1/21/2017
Olga Kantor, Catherine Pesce, Puneet Singh, Megan Miller, Jennifer Tseng, Chi-Hsiung Wang, David J Winchester, Katharine Yao Post-mastectomy radiation therapy and overall survival after neoadjuvant chemotherapy CONCLUSIONS: PMRT is associated with improved OS in patients with cN1 and cN2 disease after NAC and mastectomy. However, in the subgroup of patients that were ypN0 after NAC, PMRT improved OS for hormone-receptor negative patients but not hormone-receptor positive patients. 1/14/2017
Joanne B Weidhaas, Jonathan Harris, Dörthe Schaue, Allen M Chen, Robert Chin, Rita Axelrod, Adel K El-Naggar, Anurag K Singh, Thomas J Galloway, David Raben, Dian Wang, Chance Matthiesen, Vilija N Avizonis, Rafael R Manon, Omar Yumen, Phuc Felix Nguyen-Tan, Andy Trotti, Heath Skinner, Qiang Zhang, Robert L Ferris, David Sidransky, Christine H Chung The KRAS-Variant and Cetuximab Response in Head and Neck Squamous Cell Cancer A Secondary Analysis of a Randomized Clinical Trial CONCLUSIONS AND RELEVANCE: Patients with the KRAS-variant with HNSCC significantly benefit from the addition of cetuximab to radiotherapy and cisplatin, and there is a significant interaction between the KRAS-variant and p16 status. Elevated TGF-β1 levels in patients with the KRAS-variant suggests t... 12/23/2016
Gyulnara G Kasumova, Omidreza Tabatabaie, Mariam F Eskander, Abhishek Tadikonda, Sing Chau Ng, Jennifer F Tseng National Rise of Primary Pancreatic Carcinoid Tumors Comparison to Functional and Nonfunctional Pancreatic Neuroendocrine Tumors CONCLUSIONS: Primary pancreatic carcinoid tumors are increasingly being diagnosed. Differentiating PNET subtypes plays an important role in prognostication. Resection remains a critical component of care. 12/15/2016
Shimwoo Lee, Pascale Levine, Samantha L Heller, Osvaldo Hernandez, Cecilia L Mercado, Chloe M Chhor Metastatic carcinoid tumor to the breast report of two cases and review of the literature The breast is an unusual site for carcinoid metastasis. Due to increasing survival rates for carcinoid tumors, however, awareness of their rare complications is important. Carcinoid metastasis to the breast typically presents as a palpable breast mass or a mass on screening mammogram. Because imagin... 12/2/2016
Philip C Cooley, Christine Poulos, James I Rineer, Susan M Rogers, Matthew D Scruggs, Diane K Wagener, William D Wheaton, Bruce Y Lee Forecasting the Impact of Maternal Undernutrition on Child Health Outcomes in Indonesia Internet Maternal nutrition influences a child’s birthweight, which affects the child’s growth and subsequent survival. However, the broad consequences of maternal undernutrition and the outcomes of interventions to improve maternal nutrition take years to manifest. To examine the long-term health outcomes o... 12/1/2016
Rizhen Yu, Ji-An Chen, Jing Xu, Jin Cao, Yanlin Wang, Sandhya S Thomas, Zhaoyong Hu Suppression of muscle wasting by the plant-derived compound ursolic acid in a model of chronic kidney disease CONCLUSIONS: Ursolic acid improves CKD-induced muscle mass by suppressing the expression of myostatin and inflammatory cytokines via increasing protein synthesis and reducing proteolysis. 11/30/2016
Gyulnara G Kasumova, W Charles Conway, Jennifer F Tseng The Role of Venous and Arterial Resection in Pancreatic Cancer Surgery Pancreatic cancer continues to carry a dismal prognosis with the majority of patients presenting at advanced stages of disease. Complete surgical resection remains essential for prolonging survival and increasing the possibility of cure. However, few patients will be resectable at diagnosis, with a ... 11/25/2016
Michael Bickell, Neil Manimala, Justin Parker, Brian Steixner, Lucas Wiegand, Rafael Carrion Floppy Glans Syndrome Pathogenesis and Treatment CONCLUSION: FGS is not monolithic, and careful diagnosis is essential to determining the appropriate treatment course. 11/23/2016
Megan K Applewhite, Michael G White, Jennifer Tseng, Maryam K Mohammed, Frederic Mercier, Edwin L Kaplan, Peter Angelos, Tamara Vokes, Raymon H Grogan Normohormonal primary hyperparathyroidism is a distinct form of primary hyperparathyroidism CONCLUSION: Normohormonal primary hyperparathyroidism represents 22.5% of our primary hyperparathyroidism population, which is greater than reported previously. It is a distinct disease process from classic primary hyperparathyroidism in presentation, imaging, and operative findings. More hyperplasi... 11/22/2016
Mariam F Eskander, Susanna W L de Geus, Gyulnara G Kasumova, Sing Chau Ng, Waddah Al-Refaie, Gamze Ayata, Jennifer F Tseng Evolution and impact of lymph node dissection during pancreaticoduodenectomy for pancreatic cancer CONCLUSION: Contemporary patients have an adequate number of nodes examined during standard pancreaticoduodenectomy. This, along with rising rates of N1 cancer detection and improved survival for both node-positive and node-negative patients, suggest more accurate classification of lymph node status... 11/21/2016
Andrew T Wong, Meng Shao, Justin Rineer, Virginia Osborn, David Schwartz, David Schreiber Treatment and survival outcomes of small cell carcinoma of the esophagus an analysis of the National Cancer Data Base Given the paucity of esophageal small cell carcinoma (SCC) cases, there are few large studies evaluating this disease. In this study, the National Cancer Data Base (NCDB) was utilized to analyze the clinical features, treatment, and survival of patients with esophageal SCC in a large, population-bas... 11/19/2016
Tyler M Dvorak, Amy E Catalano, C Matt Guilliams Monitoring within non-native ungulate exclosures documents the inherent size of emCrocanthemum greeneiem Cistaceae Crocanthemum greenei (B.L.Rob.) Sorrie (Cistaceae), a perennial sub-shrub, was measured as part of a demographic monitoring effort on Santa Catalina Island, California, USA (hereafter, Catalina). Introduced ungulate browsers remain present on Catalina. Consequently, many palatable plant taxa on the ... 11/11/2016
Andrew T Wong, Justin Rineer, David Schwartz, Joseph Weiner, Joseph Safdieh, Kwang Choi, David Schreiber Patterns of adjuvant radiation usage and survival outcomes for stage I endometrial carcinoma in a large hospital-based cohort CONCLUSION: The use of adjuvant RT for women with stage I EC is highly dependent on stage/grade and is associated with improved survival for stage IB. 11/9/2016
Chloe M Chhor, Cecilia L Mercado Abbreviated MRI Protocols Wave of the Future for Breast Cancer Screening CONCLUSION: Breast MRI is not a cost-effective modality for screening women at intermediate risk, including those with dense breast tissue as the only risk. Abbreviated breast MRI protocols have been proposed as a way of achieving efficiency and rapid throughput. Use of these abbreviated protocols m... 11/5/2016
Cameron W Swanick, Katherine O Castle, Sastry Vedam, Mark F Munsell, Lehendrick M Turner, Gaiane M Rauch, Anuja Jhingran, Patricia J Eifel, Ann H Klopp Comparison of Computed Tomography- and Magnetic Resonance Imaging-based Clinical Target Volume Contours at Brachytherapy for Cervical Cancer CONCLUSIONS: We recommend MRI-based brachytherapy planning for patients with tumors >5 cm and parametrial invasion on MRI at diagnosis and for those with a high BMI. 10/30/2016
Donglan Zhang, Guijing Wang, Jing Fang, Carla Mercado Hyperlipidemia and Medical Expenditures by Cardiovascular Disease Status in US Adults CONCLUSIONS: Hyperlipidemia significantly increased medical expenditures and the increase was higher in people with CVD than without. The information on estimated expenditures could be used to evaluate and develop effective programs for CVD prevention. 10/28/2016
Yuanshui Zheng, Yixiu Kang, Omar Zeidan, Niek Schreuder An end-to-end assessment of range uncertainty in proton therapy using animal tissues Accurate assessment of range uncertainty is critical in proton therapy. However, there is a lack of data and consensus on how to evaluate the appropriate amount of uncertainty. The purpose of this study is to quantify the range uncertainty in various treatment conditions in proton therapy, using tra... 10/27/2016
Mariam F Eskander, Lindsay A Bliss, Ellen P McCarthy, Susanna W L de Geus, Sing Chau Ng, Deborah Nagle, James R Rodrigue, Jennifer F Tseng Massachusetts Healthcare Reform and Trends in Emergent Colon Resection CONCLUSIONS: There was a unique and sustained decline in the rate of emergent colon resection among publically insured and uninsured patients after 2006 in Massachusetts, in contradistinction to the national pattern, suggesting improved access to care associated with health insurance expansion. The ... 10/18/2016
Jared Andrew Shenson, Ryan Christopher Adams, S Toufeeq Ahmed, Anderson Spickard Formation of a New Entity to Support Effective Use of Technology in Medical Education The Student Technology Committee CONCLUSIONS: Students should have an integral role in advancing medical education technology to improve training for 21st-century physicians. The student technology committee model provides a framework for this integration, can be readily implemented at other institutions, and creates immediate valu... 10/13/2016
Michael Bickell, Jonathan Beilan, Jared Wallen, Lucas Wiegand, Rafael Carrion Advances in Surgical Reconstructive Techniques in the Management of Penile, Urethral, and Scrotal Cancer This article reviews the most up-to-date surgical treatment options for the reconstructive management of patients with penile, urethral, and scrotal cancer. Each organ system is examined individually. Techniques and discussion for penile cancer reconstruction include Mohs surgery, glans resurfacing,... 10/9/2016
Maria Cristina Lo Giudice, Fabian Meder, Ester Polo, Steffi S Thomas, Kholoud Alnahdi, Sandra Lara, Kenneth A Dawson Constructing bifunctional nanoparticles for dual targeting improved grafting and surface recognition assessment of multiple ligand nanoparticles Nanoparticles (NPs) functionalized with two active targeting ligands have been proposed in drug delivery for their promising capability to stimulate different pathways with one object. Due to the multivalency, the construction and analysis of the effective surface of such bifunctional nanoparticles,... 10/8/2016
Mariam F Eskander, Emily F Schapira, Lindsay A Bliss, Nikki M Burish, Abhishek Tadikonda, Sing Chau Ng, Jennifer F Tseng Keeping it in the family the impact of marital status and next of kin on cancer treatment and survival CONCLUSIONS: Marriage status was associated with improved outcomes for certain cancers whereas familial relationship with NOK was not. 10/8/2016
Andrew T Wong, Justin Rineer, David Schwartz, Daniel Becker, Joseph Safdieh, Virginia Osborn, David Schreiber Effect of Thoracic Radiotherapy Timing and Fractionation on Survival in Nonmetastatic Small Cell Lung Carcinoma CONCLUSION: These data support the early initiation of hyperfractionated thoracic RT for nonmetastatic SCLC. 10/1/2016
Kathleen N Moore, James J Java, Katrina N Slaughter, Peter G Rose, Rachelle Lanciano, Paul A DiSilvestro, J Tate Thigpen, Yi-Chun Lee, Krishnansu S Tewari, Junzo Chino, Shelly M Seward, David S Miller, Ritu Salani, David H Moore, Frederick B Stehman Is age a prognostic biomarker for survival among women with locally advanced cervical cancer treated with chemoradiation An NRG OncologyGynecologic Oncology Group ancillary data analysis CONCLUSION: This represents a large analysis of patients treated for LACC with chemo/radiation, approximately 20% of whom were >60years of age. Older patients, had higher rates of incomplete brachytherapy which is not explained by collected toxicity data. Age did not adversely impact completion of c... 8/21/2016
D Jay McCracken, Emma C Celano, Alfredo D Voloschin, William L Read, Jeffrey J Olson Phase I trial of dose-escalating metronomic temozolomide plus bevacizumab and bortezomib for patients with recurrent glioblastoma The average survival time for patients with recurrent glioblastoma is between 5 and 9 months. Phase I and II trials have shown a modest survival benefit with combination temozolomide and other chemotherapeutics. We conducted a phase I trial of dose-escalating temozolomide with bevacizumab and the pr... 8/10/2016